SATO Takuya 佐藤卓也

… Alternative Names

佐藤卓也サトウタクヤ

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Researcher Number	00316689
Other IDs
Affiliation (Current)	2022: 明海大学, 歯学部, 准教授
Affiliation (based on the past Project Information) *help	2019 – 2021: 明海大学, 歯学部, 准教授 2013 – 2015: 明海大学, 歯学部, 講師 2004 – 2011: Meikai University, School of Dentistry, Department of Oral Anatomy, Lecturer, 歯学部, 講師 2003: 明海大学, 歯学部, 助手 2000 – 2001: 明海大学, 歯学部, 助手
Review Section/Research Field	Principal Investigator Morphological basic dentistry / Morphological basic dentistry / Basic Section 57030:Conservative dentistry-related Except Principal Investigator Morphological basic dentistry / Morphological basic dentistry
Keywords	Principal Investigator 破骨細胞 / limitin / 骨吸収 / B細胞 / osteoclasts / periodontitis / B220抗原 / 骨代謝 / 酒石酸耐性酸性ホスファターゼ / 歯周病 … More / bone resorption / I型インターフェロン / 歯周炎 / 1型インターフェロン / type-linterferon / 骨細胞 / 副甲状腺ホルモン / サイトカイン / 骨形成促進 / 骨形成 / 歯槽骨 … More Except Principal Investigator RANKL / 破骨細胞 / 破骨細胞分化 / TGF-β / 破骨細胞形成 / 骨芽細胞 / 骨吸収 / osteoclastogenesis / caveolin-1 / VEGF / FGF-2 / FLT1 / FLK1 / FGFR1 / beta ig-h3 / OPG / lipid / raft / コレステロール / NFATc1 / FcRY / カベオリン1 / 脂質ラフト / カベオリン1ノックアウトマウス / FcRγ / LDL受容体 / scavenger receptor / ノックアウトマウス / 細胞融合タンパク質 / 分泌機構 / 炎症性骨破壊 / LOX-1 / 炎症性骨吸収 / 細胞融合 / RANKL産生 / 血管新生因子 / 骨呼吸 / 血管新生 / bFGF / 骨吸収活性 / チロシンリン酸化 / MAPK / osteoclast / bone resolution / angiogenic factors / 破骨細胞前駆細胞 / RGD配列 / インテグリン / オステオポンチン / 接着タンパク / osteoclast progenitors / RGD sequence / integrin / osteopontin / 骨 / シェアストレス / プロスタグランジン / 破骨細胞文化 / bone / fluid shear stress / osteoblasts / bone resorption / prostaglandin Less

副甲状腺ホルモンの骨形成促進作用を仲介する骨細胞由来の骨形成促進因子を同定するPrincipal Investigator
- Principal Investigator
  
  佐藤卓也
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Meikai University
The elucidation of the role of lipid in bone resorption of inflammatory bone diseases; in particular, the exploration of the role of LOX-1 as an oxidized LDL receptor
- Principal Investigator
  
  HAKEDA Yoshiyuki
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Meikai University
DEPENDENCY OF OSTEOCLAST DIFFERENTIATION ON EXOGENOUS CHOLESTEROL AND ROLE OF CAVEOLIN-1 IN OSTEOCLASTOGENESIS
- Principal Investigator
  
  HAKEDA Yoshiyuki
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Meikai University
Elucidation on roles of caveolae/lipid raft on osteoclast differentiation and bone resorption and on intracellular trafficking of caveolin-1
- Principal Investigator
  
  HAKEDA Yoshiyuki
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Meikai University
Studies of limitin as a therapeutic agent for periodontitis : analysis of mechanisms of inhibition of osteoclastogenesisPrincipal Investigator
- Principal Investigator
  
  SATO Takuya
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Meikai University
Investigation of action of shear stress, which is produced by Mechanical loading applied to the skeleton, on osteodast formation and bone-resorbing activity
- Principal Investigator
  
  HAKEDA Yoshiyuki
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Meikai University
Studies of limitin for prevention of bone resorption in bacterial periodontitisPrincipal Investigator
- Principal Investigator
  
  SATO Takuya
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Meikai University
Elucidation of role of beta ig-3 derived from osteoclasts in bone resorption and formation
- Principal Investigator
  
  HAKEDA Yoshiyuki
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Meikai University
破骨細胞への分化能を有するB細胞系細胞の同定、病的骨吸収での役割を研究Principal Investigator
- Principal Investigator
  
  佐藤卓也
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Meikai University
Elucidation of mechanism for regulation of osteoclastic differentiation and function by angiogenic factors.
- Principal Investigator
  
  KUMEGAWA Masayoshi
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Meikai University

All 2020 2015 2013 2012 2011 2009 2007 2004 2003 Other

All Journal Article Presentation

[Journal Article] Lectin-like oxidized　low-density lipoprotein receptor-1 abrogation causes resistance to inflammatory bone destruction in mice, despite promoting osteoclastogenesis in the steady state2015
- Author(s)
  Nakayachi M, Ito J, Hayashida C, Ohyama Y, Kakino A, Okayasu M, Sato T, Ogasawara T, Kaneda T, Suda N, Sawamura T, Hakeda Y
- Journal Title
  
  BONE
  
  Volume: 75 Pages: 170-182
- DOI
  10.1016/j.bone.2015.02.025
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24659916, KAKENHI-PROJECT-25293422, KAKENHI-PROJECT-26870540, KAKENHI-PROJECT-26463085, KAKENHI-PROJECT-15K15759, KAKENHI-PROJECT-26670895, KAKENHI-PROJECT-25293376
[Journal Article] Receptor activator of NF-kB ligand-dependent expression of caveolin-1 in osteoclast precursors and high dependency of osteoclastogenesis on exogenous lipoprotein2012
- Author(s)
  Hada N, Okayasu M, Ito J, Nakayachi M, Hayashida C, Kaneda T, Uchida N, Muramatsu T, Koike C, Masuhara M, Sato T, Hakeda Y
- Journal Title
  
  Bone
  
  Volume: 50 Pages: 226-236
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592341
[Journal Article] Low-density lipoprotein receptor deficiency causes impaired osteoclastogenesis and increased bone mass in mice because of defect in osteoclastic cell-cell fusion2012
- Author(s)
  Okayasu M, Nakayachi M, Hayashida C, Ito J, Kaneda T, Masuhara M, Suda N, Sato T, Hakeda Y
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: (In press) Pages: 19229-19241
- DOI
  10.1074/jbc.m111.323600
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592341, KAKENHI-PROJECT-22791792, KAKENHI-PROJECT-23593018, KAKENHI-PROJECT-24593079
[Journal Article] IFN-ζ/limitin inhibits generation of osteoclast precursors.2009
- Author(s)
  Sato, T., Masuhara, M., Hada, N., Okayasu, M., Hakeda, Y.
- Journal Title
  
  J. Meikai Dent. Med. 38
  
  Pages: 1-8
- NAID
  40016525912
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592130
[Journal Article] Protective protein/cathepsin A down-regulates osteoclastogenesis by associating with and degrading NF-kB p50/p65.2009
- Author(s)
  Masuhara, M.,Sato, T. Hada, N., Hakeda, Y.
- Journal Title
  
  J. Bone Miner. Metab. 27
  
  Pages: 46-56
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592130
[Journal Article] Production of IL-7 is increased in ovariectomized mice, but not RANKL mRNA expression by osteoblasts/stromal cells in bone, and IL-7 enhances generation of osteoclast precursors in vitro.2007
- Author(s)
  Sato, T., Watanabe, K., Masuhara, M., Hada, N., Hakeda, Y.
- Journal Title
  
  J. Bone Miner. Metab. 25
  
  Pages: 19-27
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591922
[Journal Article] Production of IL-7 is increased in ovariectomized mice, but not RANKL mRNA expression by osteoblasts/stromal cells in bone, and IL-7 enhances generation of osteoclast precursors in vitro.2007
- Author(s)
  TAKUYA SATO
- Journal Title
  
  Journal of Bone and Mineral Metabolism 25・1
  
  Pages: 19-27
- Data Source
  KAKENHI-PROJECT-18592007
[Journal Article] The active metabolite of leflunomide, A771726, inhibits both the generation of and the bone-resorbing activity of osteoclasts by acting directly on cells of the osteoclast lineage2004
- Author(s)
  Kobayashi Y, Ueyama S, Arai Y, Yoshida Y, Kaneda T, Sato T, Shin K, Kumegawa M, Hakeda Y
- Journal Title
  
  J. Bone Miner. Metab. 22
  
  Pages: 318-328
- NAID
  10013606023
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591946
[Journal Article] The active metabolite of lefluonomide, A771726,inhibits both the generation of and the bone-resorbing activity of osteoclasts by acting directly on cells of the osteoclast lineage.2004
- Author(s)
  Kobayashi, Y., Ueyama, S., Arai, Y., Yoshida, Y., Kaneda, T., Sato, T., Shin, K., Kumegawa, M., Hakeda, Y.
- Journal Title
  
  J.Bone Miner.Metab. 22
  
  Pages: 318-328
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591946
[Journal Article] Dexamethasone enhances osteoclast formation synergistically with transforming growth factor-b by stimulating the priming of osteolast progenitors for differentiation into osteoclasts.2003
- Author(s)
  Takuma, A., Kaneda, T., Sato, T., Ninomiya, S., Kumegawa, M., Hakeda, Y.
- Journal Title
  
  J.Biol.Chem. 278
  
  Pages: 44667-44674
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591946
[Journal Article] Dexamethasone enhances osteoclast formation synergistically with transforming growth factor-b by stimulating the priming of osteoclast progenitors for differentiation into osteoclasts2003
- Author(s)
  Takuma A, Kaneda T, Sato T, Ninomiya S, Kumegawa M, Hakeda Y
- Journal Title
  
  J. Biol. Chem. 278
  
  Pages: 44667-44674
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591946
[Presentation] 骨細胞のみを含む骨片（osteocyte-enriched bone fragment, OEBF）培養系における副甲状腺ホルモンPTH の作用について2020
- Author(s)
  林田　千代美、佐藤　卓也
- Organizer
  日本解剖学会第108回関東支部学術集会
- Data Source
  KAKENHI-PROJECT-19K10114
[Presentation] レクチン様酸化LDL受容体-1 (LOX-1)欠損は定常状態における破骨細胞形成を促進するが、LPS誘導炎症性骨破壊に抵抗性を示す2015
- Author(s)
  伊東順太、林田千代美、大山洋子、佐藤卓也、羽毛田慈之
- Organizer
  第33回日本骨代謝学会学術集会
- Place of Presentation
  京王プラザホテル（新宿）
- Year and Date
  2015-07-23
- Data Source
  KAKENHI-PROJECT-25293376
[Presentation] レクチン様酸化LDL受容体-1(LOX-1)の破骨細胞形成と炎症性骨破壊に対する役割の解明2013
- Author(s)
  伊東順太、中谷地舞、林田千代美、岡安麻里、大山洋子、佐藤卓也、羽毛田慈之
- Organizer
  第55回歯科基礎医学会学術大会・総会
- Place of Presentation
  岡山コンベンションセンター、岡山、岡山県
- Data Source
  KAKENHI-PROJECT-25293376
[Presentation] Role of lectin-like oxidized low-density of lipoprotein receptor-1 in regulating osteoclastogenesis and inflammatory bone destruction.2013
- Author(s)
  Nakayachi M, Ito J, Okayasu M, Hayashida C, Sato T, Suda N, Sawamura T, Hakeda
- Organizer
  2nd Joint Meeting of the International Bone and Mineral Society and the Japanese Society for Bone and Mineral Research
- Place of Presentation
  Kobe Convention Center and Kobe Portpia Hotel, Kobe, Japan
- Data Source
  KAKENHI-PROJECT-25293376
[Presentation] Lectin-like oxidized low-density of lipoprotein receptor-1 is involved in RANKL-production elevated by lipopolysaccharide-injection on mouse calvaria and thereby contributes to inflammatory bone destruction2013
- Author(s)
  Nakayachi M, Ito J, Okayasu M, Hayashida C, Sato T, Suda N, Sawamura T, Hakeda Y.
- Organizer
  35th Annual Meeting of the American Society for Bone and Mineral Research
- Place of Presentation
  Baltimore Convention Center, Baltimore, Maryland, USA
- Data Source
  KAKENHI-PROJECT-25293376
[Presentation] マウス長骨からの骨細胞の分離方法の検討2011
- Author(s)
  林田千代美, 佐藤卓也, 中谷地舞, 伊東順太, 岡安麻里, 羽毛田慈之
- Organizer
  第54回歯科基礎医学会学術大会
- Place of Presentation
  岐阜
- Data Source
  KAKENHI-PROJECT-21592341
[Presentation] Exogenous Cholesterol, and Deficiency of LowDensity Lipoprotein Receptor in Mice CausesImpaired Osteoclastic Cell Fusion and Increase in Bone Mass2011
- Author(s)
  Okayasu M, Hayashida C, Nakayachi M, Sato T, Ito J, Suda N, Hakeda Y
- Organizer
  ASBMR 2011 Annual Meeting
- Place of Presentation
  SanDiego, California, USA
- Data Source
  KAKENHI-PROJECT-21592341
[Presentation] 株化骨細胞MLO-Y4はOPG以外の液性の破骨細胞形成抑制性因子を産生する2011
- Author(s)
  林田千代美, 佐藤卓也, 岡安麻里, 中谷地舞, 伊藤順太, 羽毛田慈之
- Organizer
  第23回日本骨代謝学会学術集会
- Place of Presentation
  大阪国際会議場(大阪府)
- Data Source
  KAKENHI-PROJECT-21592341
[Presentation] 破骨細胞分化過程における細胞内cholesterol減少は, Atp6v0d2を介する細胞融合を抑制し骨量を増加する2011
- Author(s)
  岡安麻里, 林田千代美, 中谷地舞, 佐藤卓也, 伊東順太, 須田直人, 羽毛田慈之
- Organizer
  第54回歯科基礎医学会学術大会
- Place of Presentation
  岐阜
- Data Source
  KAKENHI-PROJECT-21592341
[Presentation] 破骨細胞分化は細胞外cholesterolに依存し, low density lipoprotein receptor欠損マウスは破骨細胞の融合障害に起因した骨量増加をみる2011
- Author(s)
  岡安麻里, 林田千代美, 中谷地舞, 佐藤卓也, 伊東順太, 須田直人, 羽毛田慈之
- Organizer
  第23回日本骨代謝学会学術集会
- Place of Presentation
  大阪国際会議場(大阪府)
- Data Source
  KAKENHI-PROJECT-21592341
[Presentation] レクチン様酸化LDL受容体-1 (LOX-1)欠損は定常状態における破骨細胞形成を促進するが、LPS誘導炎症性骨破壊に抵抗性を示す
- Author(s)
  伊東順太、林田千代美、大山洋子、佐藤卓也、羽毛田慈之
- Organizer
  第33回日本骨代謝学会学術集会
- Place of Presentation
  東京
- Year and Date
  2015-07-23 – 2015-07-25
- Data Source
  KAKENHI-PROJECT-25293376

1. HAKEDA Yoshiyuki (90164772)

# of Collaborated Projects: 6 results

# of Collaborated Products: 20 results
2. MASUHARA Masaaki (70372901)

# of Collaborated Projects: 4 results

# of Collaborated Products: 5 results
3. KANEDA Toshio (70339521)

# of Collaborated Projects: 3 results

# of Collaborated Products: 7 results
4. HAYASHIDA Chiyomi (40710900)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
5. OKAYASU Mari (10610941)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
6. OGASAWARA Toru (20359623)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. SAWAMURA Tatsuya (30243033)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
8. ITO Junta (40609096)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
9. KUMEGAWA Masayoshi (40049367)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 須田直人

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

SATO Takuya 佐藤 卓也

佐藤 卓也 サトウ タクヤ

Research Projects

Research Products

Co-Researchers

副甲状腺ホルモンの骨形成促進作用を仲介する骨細胞由来の骨形成促進因子を同定するPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The elucidation of the role of lipid in bone resorption of inflammatory bone diseases; in particular, the exploration of the role of LOX-1 as an oxidized LDL receptor

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

DEPENDENCY OF OSTEOCLAST DIFFERENTIATION ON EXOGENOUS CHOLESTEROL AND ROLE OF CAVEOLIN-1 IN OSTEOCLASTOGENESIS

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation on roles of caveolae/lipid raft on osteoclast differentiation and bone resorption and on intracellular trafficking of caveolin-1

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies of limitin as a therapeutic agent for periodontitis : analysis of mechanisms of inhibition of osteoclastogenesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation of action of shear stress, which is produced by Mechanical loading applied to the skeleton, on osteodast formation and bone-resorbing activity

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies of limitin for prevention of bone resorption in bacterial periodontitisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of role of beta ig-3 derived from osteoclasts in bone resorption and formation

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

破骨細胞への分化能を有するB細胞系細胞の同定、病的骨吸収での役割を研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of mechanism for regulation of osteoclastic differentiation and function by angiogenic factors.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Lectin-like oxidized low-density lipoprotein receptor-1 abrogation causes resistance to inflammatory bone destruction in mice, despite promoting osteoclastogenesis in the steady state2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Receptor activator of NF-kB ligand-dependent expression of caveolin-1 in osteoclast precursors and high dependency of osteoclastogenesis on exogenous lipoprotein2012

Author(s)

Journal Title

Data Source

[Journal Article] Low-density lipoprotein receptor deficiency causes impaired osteoclastogenesis and increased bone mass in mice because of defect in osteoclastic cell-cell fusion2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] IFN-ζ/limitin inhibits generation of osteoclast precursors.2009

SATO Takuya 佐藤卓也

佐藤卓也サトウタクヤ

[Journal Article] Lectin-like oxidized　low-density lipoprotein receptor-1 abrogation causes resistance to inflammatory bone destruction in mice, despite promoting osteoclastogenesis in the steady state2015