HAKEDA Yoshiyuki 羽毛田慈之

… Alternative Names

羽毛田慈之ハケダヨシユキ

羽毛田慈行ハケダヨシユキ

Less

Researcher Number	90164772
Affiliation (Current)	2023: 明海大学, 歯学部, 名誉教授
Affiliation (based on the past Project Information) *help	2002 – 2021: Meikai Univ., Dental School, Professor, 歯学部, 教授 2020: 明海大学, 歯学部, 名誉教授 2001: 明治大学, 歯学部・口腔解剖学教室, 助教授 2000 – 2001: 明海大学, 歯学部・口腔解剖学講座, 助教授 1994 – 2001: 明海大学, 歯学部, 助教授 … More 1993: Meikai University, Dept.Dentistry, Instructor, 歯学部, 講師 1991: 明海大学, 歯学部, 講師 1988: Meikai University School of Dentistry, 歯学部, 助手 1987: 城西歯科大学, 歯学部, 助手 Less
Review Section/Research Field	Principal Investigator Morphological basic dentistry / Morphological basic dentistry / Periodontology Except Principal Investigator Morphological basic dentistry / Basic Section 57060:Surgical dentistry-related / Basic Section 57040:Regenerative dentistry and dental engineering-related / Surgical dentistry / Conservative dentistry / Functional basic dentistry / Functional basic dentistry / Periodontal dentistry / Orthodontic/Pediatric dentistry
Keywords	Principal Investigator 破骨細胞 / RANKL / 骨吸収 / bone resorption / LOX-1 / 骨芽細胞 / 炎症性骨破壊 / 破骨細胞形成 / TGF-β / 破骨細胞分化 … More / OPG / osteoclastogenesis / beta ig-h3 / Pi cotransporter-2 / Na / FAK / PI3-kinase / c-src / Tyro3 / Gas6 / 骨吸収活性 / estrogen / apoptosis / osteoclast / 細胞融合 / 炎症性骨吸収 / LDL受容体 / caveolin-1 / 脂質 / 炎症整骨破壊 / ABCG1 / phosphatidylethanolamine / 細胞膜外葉 / prostaglandin / osteoblasts / fluid shear stress / bone / 破骨細胞文化 / プロスタグランジン / シェアストレス / 骨 / osteopontin / integrin / RGD sequence / osteoclast progenitors / 接着タンパク / オステオポンチン / インテグリン / RGD配列 / 破骨細胞前駆細胞 / calcium-sensing receptor / extracellular phosphorus / extracellular calcium / bone-resorbing activity / osteoclasts / Ca^<2+>感知受容体 / 細胞外PO_4^<3-> / 骨呼吸活性 / Picotransporter-2 / PO^<2+>感知受容体 / 細胞外Ca_4^<3-> / 細胞外Ca^<2+> / Bone marrow cells / Bone resorption / Osteoclasts / Tyrosine phosphorylation / Quantitative RT-PCR / トランスフェクション / Tyro-3 / 骨髄細胞 / エストロジェン受容体 / エストロジェン / OC-2 / Cathepsin K / osteoclast-specific antigens / osteoclast-specific antibody / osteoclast formation / 酒石酸耐性酸ホスファターゼ / 小腸 / 5H抗体 / 5H抗原 / 破骨細胞特異膜抗原 / 破骨細胞特異抗体 / 実験的歯周炎モデル / 歯周病 / RANKL産生 / 分泌機構 / 細胞融合タンパク質 / ノックアウトマウス / scavenger receptor / FcRγ / カベオリン1ノックアウトマウス / 脂質ラフト / カベオリン1 / FcRY / NFATc1 / コレステロール / raft / lipid … More Except Principal Investigator 破骨細胞 / VEGF / 骨細胞 / 骨芽細胞 / Osteoclasts / 骨吸収 / 再生医療 / 細胞周期 / mechanical stress / メカニカルストレス / PTH / FGFR1 / FLK1 / FLT1 / FGF-2 / チロシンリン酸化 / Gas6 / Tyro3 / FGFR-1 / 骨形成 / 破骨細胞形成 / 骨代謝 / 骨軟骨代謝学 / G0/G1期 / 骨格幹細胞 / 骨誘導 / scaffold / 骨移植 / 骨再生 / コントロールリリース / 生体吸収性材料 / 骨増生 / 顎骨再建 / PLGA / 骨誘導因子 / 未分化細胞 / 細胞分化 / 骨代謝学 / シグナル伝達 / microRNA / 再生医学 / 発生・分化 / micro RNA / Multinucleated cell / 1alpha,25-Dihydroxyvitamin D_3 / Bone marrow cell / 1α,25(OH)_2_3-26,23-1actone / 破骨細胞様多核細胞 / 1α,25(OH)_2D_3 / カルシトニン / 1α,25ージヒドロキシビタミンD_3ー26,23ーラクトン / 1α,25ージヒドロキシビタミンD_3 / 1α、25-ジヒドロキシビタミンD_3-26、23-ラクトン / 多核細胞 / 1α、25-ジヒドロキシビタミンD_3 / 骨髄細胞 / Osteoblasts / 骨茅細胞 / 局所因子 / osteoblast / parathyroid hormon / 重力負荷 / PTH受容体 / 副甲状腺ホルモン / PTH receptor / osteoporosis / osteocyte / PTH Receptor / PTHレセプター / 骨粗鬆症 / メカニカルスレス / CD4+ T cells / human immune response / periodontitis / Actinohacilllis actinnmycetemcomitans / NOD-SCID mouse / IgG / Limiting Dilution Assay / Actinobacillus actionomycetemcomitans / SCODマウス / NOD / CD4^+T細胞 / ヒトリンパ球 / Actinobacillus actinomycetemcomitans / プラーク(細菌塊) / NOD-SCIDマウス / angiogenic factors / osteoclastogenesis / bone resolution / osteoclast / MAPK / 骨吸収活性 / bFGF / 血管新生 / 骨呼吸 / 血管新生因子 / BMP-2 / Bone resorption / Tyro-3リガンド Gas6 / チロシンキナーゼ Tyro-3 / 破骨細胞の活性化機構 / 受容体型チロシンキナーゼ / 生存率 / FLK-1 / FLT-1 / BMF-2 / Bone rescorption / Vitamin D_3 / Ca receptor / Rho-GDI like protein / Inhibition of bone resorption / Osteocytes / 破骨細胞抑制因子 / Pho-GDIタンパク質 / ビタミンD / カルシウム受容体 / Pho-GDI様タンパク質 / 破骨細胞の活性抑制 / OSTEOCLAST FUNCTION / OSTEOCLAST FORMATION / OSTEOCYTES / CYTOKINES / ホルモン / Bone cell / cathepsin-L様物質 / osteopontin / TGF-β / 破骨細胞機能 / サイトカイン / LDL受容体 / コレステロール / ＬＤＬ / lipid raft Less

Cdk6による骨格幹細胞G0/G1期制御機構の解明と骨再生医療に向けた基礎的検討
- Principal Investigator
  
  小笠原徹
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  The University of Tokyo
細胞リクルートを目的とする分化誘導因子含有scaffoldの顎骨再建への応用
- Principal Investigator
  
  虻川東嗣
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57040:Regenerative dentistry and dental engineering-related
- Research Institution
  Meikai University
Elucidation of Involvement of LOX-1 in inflammatory bone destruction and the molecular mechanism for the LOX-1 actions, and an approach to develop the new drug for bone diseases.Principal Investigator
- Principal Investigator
  
  HAKEDA Yoshiyuki
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Meikai University
Identification of microRNAs controlled by Cdk6 for understanding of bone metabolism system and their application for regenerative medicine
- Principal Investigator
  
  OGASAWARA Toru
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  The University of Tokyo
Trial study for the establishment of the new therapeutical method for periodontal disease that targets oxidation LDL receptor LOX-1.Principal Investigator
- Principal Investigator
  
  HAKEDA Yoshiyuki
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Periodontology
- Research Institution
  Meikai University
The elucidation of the role of lipid in bone resorption of inflammatory bone diseases; in particular, the exploration of the role of LOX-1 as an oxidized LDL receptorPrincipal Investigator
- Principal Investigator
  
  HAKEDA Yoshiyuki
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Meikai University
Mechanism and its regulation of lipid rafts in the osteoclastic resorption of bone
- Principal Investigator
  
  OKAYASU Mari
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthodontic/Pediatric dentistry
- Research Institution
  The University of Tokyo
DEPENDENCY OF OSTEOCLAST DIFFERENTIATION ON EXOGENOUS CHOLESTEROL AND ROLE OF CAVEOLIN-1 IN OSTEOCLASTOGENESISPrincipal Investigator
- Principal Investigator
  
  HAKEDA Yoshiyuki
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Meikai University
Elucidation on roles of caveolae/lipid raft on osteoclast differentiation and bone resorption and on intracellular trafficking of caveolin-1Principal Investigator
- Principal Investigator
  
  HAKEDA Yoshiyuki
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Meikai University
Investigation of action of shear stress, which is produced by Mechanical loading applied to the skeleton, on osteodast formation and bone-resorbing activityPrincipal Investigator
- Principal Investigator
  
  HAKEDA Yoshiyuki
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Meikai University
Elucidation of role of beta ig-3 derived from osteoclasts in bone resorption and formationPrincipal Investigator
- Principal Investigator
  
  HAKEDA Yoshiyuki
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Meikai University
Effect of mechanical stress on osteogenesis facilitating by parathyroid hormone
- Principal Investigator
  
  ARAKAWA Toshiya
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Health Sciences University of Hokkaido
Identification of genes induced by mechanical stress in osteocytes
- Principal Investigator
  
  ARAKAWA Toshiya
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Health Sciences University of Hokkaido
Elucidation of mechanism for regulation of osteoclastic differentiation and function by angiogenic factors.
- Principal Investigator
  
  KUMEGAWA Masayoshi
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Meikai University
Elucidation of regulatory mechanism of osteoclast differentiation and function by extracellular calcium and phosphorus.Principal Investigator
- Principal Investigator
  
  HAKEDA Yoshiyuki
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Meikai University
Analysis of human immune response in periodontitis using a noble mouse model
- Principal Investigator
  
  NOBUMICHI Hozumi
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Periodontal dentistry
- Research Institution
  Tokyo University of Science
Tyro-3 receptor tyrosine kinase and its ligand, Gas6, stimulate the function of osteoclastsPrincipal Investigator
- Principal Investigator
  
  HANEDA Yoshiyuki
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Meikai University
Study of roles of receptor tyrosine kinases in regulating osteoclast function.
- Principal Investigator
  
  KUMEGAWA Masayoshi
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Meikai University
Study on direct action of estrogen on mature osteoclastsPrincipal Investigator
- Principal Investigator
  
  HAKEDA Yoshiyuki
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Meikai University School of Dentistry
Functions of osteocytes in bone metabolism
- Principal Investigator
  
  KUMEGAWA Masayoshi
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Meikai University
Analysis of osteoclast-specificmembrane-bound proteins that are expressed during osteoclast differentiationPrincipal Investigator
- Principal Investigator
  
  HAKEDA Yoshiyuki
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Meikai University
Regulation of bone metabolism - especially by bone cell interaction
- Principal Investigator
  
  KUMEGAWA Masayoshi
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Meikai University
The effects of local factors on bone remodeling
- Principal Investigator
  
  KUMEGAWA Masayoshi
- Project Period (FY)
  1987 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Meikai University
Development of the cell culture system to examine the mechanism of the action on bone-resorbing factors in vitro.
- Principal Investigator
  
  SHIMOJIMA Takahiro, 栗橋徳善
- Project Period (FY)
  1987 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Conservative dentistry
- Research Institution
  Department of Periodontology, Meikai University School of Dentistry

[Journal Article] LDL uptake-dependent phosphatidylethanolamine translocation to the cell surface promotes fusion of osteoclast-like cells.2020
- Author(s)
  Kitano J F V, Ohyama Y, Hayashida C, Ito J, Okayasu M, Sato T, Ogasawara T, Tsujita M, Kakino A, Shimada J, Sawamura T, and Hakeda Y.
- Journal Title
  
  Journal of Cell Science
  
  Volume: ー
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05505
[Journal Article] The polymethoxy flavonoid sudachitin suppresses inflammatory bone destruction by directly inhibiting osteoclastogenesis due to reduced ROS production and MAPK activation in osteoclast precursors2018
- Author(s)
  Ohyama Yoko、Ito Junta、Kitano Victor J.、Shimada Jun、Hakeda Yoshiyuki
- Journal Title
  
  PLOS ONE
  
  Volume: 13 Issue: 1 Pages: e0191192-e0191192
- DOI
  10.1371/journal.pone.0191192
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K20677, KAKENHI-PROJECT-16H05505
[Journal Article] Lectin-like oxidized low-density lipoprotein receptor-1 abrogation causes resistance to inflammatory bone destruction in mice, despite promoting osteoclastogenesis in the steady state.2015
- Author(s)
  Nakayachi M, Ito J, Hayashida C, Ohyama Y, Kakino A, Okayasu M, Sato T, Ogasawara T, Kaneda T, Suda N, Sawamura T, Hakeda Y
- Journal Title
  
  Bone. 75:170-182
  
  Volume: 75 Pages: 170-182
- DOI
  10.1016/j.bone.2015.02.025
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24659916, KAKENHI-PROJECT-25293422, KAKENHI-PROJECT-26870540, KAKENHI-PROJECT-26463085, KAKENHI-PROJECT-15K15759, KAKENHI-PROJECT-26670895, KAKENHI-PROJECT-25293376
[Journal Article] Receptor activator of NF-kB ligand-dependent expression of caveolin-1 in osteoclast precursors and high dependency of osteoclastogenesis on exogenous lipoprotein2012
- Author(s)
  Hada N, Okayasu M, Ito J, Nakayachi M, Hayashida C, Kaneda T, Uchida N, Muramatsu T, Koike C, Masuhara M, Sato T, Hakeda Y
- Journal Title
  
  Bone
  
  Volume: 50 Pages: 226-236
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592341
[Journal Article] Low-density lipoprotein receptor deficiency causes impaired osteoclastogenesis and increased bone mass in mice due to a defect in osteoclasticcell-cell fusion2012
- Author(s)
  Okayasu M, Nakayachi M, Hayashida C, Ito J, Kaneda T, Masuhara M, Suda N, Sato T, Hakeda Y
- Journal Title
  
  J Biol Chem
  
  Volume: (In press) Issue: 23 Pages: 19229-19241
- DOI
  10.1074/jbc.m111.323600
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592341, KAKENHI-PROJECT-22791792, KAKENHI-PROJECT-23593018, KAKENHI-PROJECT-24593079
[Journal Article] IFN-ζ/limitin inhibits generation of osteoclast precursors.2009
- Author(s)
  Sato, T., Masuhara, M., Hada, N., Okayasu, M., Hakeda, Y.
- Journal Title
  
  J. Meikai Dent. Med. 38
  
  Pages: 1-8
- NAID
  40016525912
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592130
[Journal Article] Protective protein/cathepsin A down-regulates osteoclastogenesis by associating with and degrading NF-kB p50/p65.2009
- Author(s)
  Masuhara, M.,Sato, T. Hada, N., Hakeda, Y.
- Journal Title
  
  J. Bone Miner. Metab. 27
  
  Pages: 46-56
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592130
[Journal Article] Production of IL-7 is increased in ovariectomized mice, but not RANKL mRNA expression by osteoblasts/stromal cells in bone, and IL-7 enhances generation of osteoclast precursors in vitro.2007
- Author(s)
  Sato, T., Watanabe, K., Masuhara, M., Hada, N., Hakeda, Y.
- Journal Title
  
  J. Bone Miner. Metab. 25
  
  Pages: 19-27
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591922
[Journal Article] グルココルチコイドの骨形成系・骨吸収系細胞に対する作用2006
- Author(s)
  羽毛田慈之
- Journal Title
  
  Cinical Calcium 16
  
  Pages: 817-822
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591922
[Journal Article] Action of glucocorticoid on bone-forming and bone-resorbing cells.2006
- Author(s)
  Hakeda Y.
- Journal Title
  
  Clin Calcium 16(11)
  
  Pages: 1817-22
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591922
[Journal Article] The active metabolite of leflunomide, A771726, inhibits both the generation of and the bone-resorbing activity of osteoclasts by acting directly on cells of the osteoclast lineage2004
- Author(s)
  Kobayashi Y, Ueyama S, Arai Y, Yoshida Y, Kaneda T, Sato T, Shin K, Kumegawa M, Hakeda Y
- Journal Title
  
  J. Bone Miner. Metab. 22
  
  Pages: 318-328
- NAID
  10013606023
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591946
[Journal Article] The active metabolite of lefluonomide, A771726,inhibits both the generation of and the bone-resorbing activity of osteoclasts by acting directly on cells of the osteoclast lineage.2004
- Author(s)
  Kobayashi, Y., Ueyama, S., Arai, Y., Yoshida, Y., Kaneda, T., Sato, T., Shin, K., Kumegawa, M., Hakeda, Y.
- Journal Title
  
  J.Bone Miner.Metab. 22
  
  Pages: 318-328
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591946
[Journal Article] Dexamethasone enhances osteoclast formation synergistically with transforming growth factor-b by stimulating the priming of osteolast progenitors for differentiation into osteoclasts.2003
- Author(s)
  Takuma, A., Kaneda, T., Sato, T., Ninomiya, S., Kumegawa, M., Hakeda, Y.
- Journal Title
  
  J.Biol.Chem. 278
  
  Pages: 44667-44674
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591946
[Journal Article] Dexamethasone enhances osteoclast formation synergistically with transforming growth factor-b by stimulating the priming of osteoclast progenitors for differentiation into osteoclasts2003
- Author(s)
  Takuma A, Kaneda T, Sato T, Ninomiya S, Kumegawa M, Hakeda Y
- Journal Title
  
  J. Biol. Chem. 278
  
  Pages: 44667-44674
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591946
[Presentation] Low-density lipoproteinの細胞内への取り込みに依存したホスファチジルエタノールアミンの細胞膜外葉への局在変換は破骨細胞の融合過程に関与する2019
- Author(s)
  羽毛田慈之、Victor Jose Flores Kitano, 大山洋子、林田千代美、佐藤卓也、嶋田淳
- Organizer
  第６１回歯科基礎医学会
- Data Source
  KAKENHI-PROJECT-16H05505
[Presentation] スダチ果皮特有ポリメトキシフラボノイドsudachitinは破骨細胞形成およびLPS誘導炎症性骨破壊を抑制する2016
- Author(s)
  伊東順太、大山洋子、林田千代美、佐藤卓也、羽毛田慈之
- Organizer
  第34回日本骨代謝学会学術集会・第3回アジア太平洋骨代謝学会議
- Place of Presentation
  大阪国際会議場
- Year and Date
  2016-07-20
- Data Source
  KAKENHI-PROJECT-16H05505
[Presentation] Sudachitin, a polymethoxyflavone derived from Citrus sudachi, suppresses lipopolysaccharide-induced inflammatory bone resorption because of inhibiting osteoclast formation in mice2016
- Author(s)
  Ohyama Y., Ito J.,Hakeda Y., Shimada J.
- Organizer
  98th Annual Meeting of American Association of Oral and Maxillofacial Surgeons
- Place of Presentation
  Las Vegas, USA
- Year and Date
  2016-09-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05505
[Presentation] レクチン様酸化LDL受容体-1 (LOX-1)欠損は定常状態における破骨細胞形成を促進するが、LPS誘導炎症性骨破壊に抵抗性を示す2015
- Author(s)
  伊東順太、林田千代美、大山洋子、佐藤卓也、羽毛田慈之
- Organizer
  第33回日本骨代謝学会学術集会
- Place of Presentation
  京王プラザホテル（新宿）
- Year and Date
  2015-07-23
- Data Source
  KAKENHI-PROJECT-25293376
[Presentation] レクチン様酸化LDL受容体-1 (LOX-1)欠損は定常状態における破骨細胞形成を促進するが、LPS誘導炎症性骨破壊には抵抗性を示す2015
- Author(s)
  伊東順太、林田千代美、大山洋子、佐藤卓也、羽毛田慈之
- Organizer
  第57回歯科基礎医学会学術大会
- Place of Presentation
  朱鷺メッセ（新潟コンベンションセンター）
- Year and Date
  2015-09-11
- Data Source
  KAKENHI-PROJECT-26670895
[Presentation] レクチン様酸化LDL受容体-1 (LOX-1)欠損は定常状態における破骨細胞形成を促進するが、LPS誘導炎症性骨破壊に抵抗性を示す2015
- Author(s)
  伊東順太、林田千代美、大山洋子、佐藤卓也、羽毛田慈之
- Organizer
  第33回日本骨代謝学会学術集会
- Place of Presentation
  京王プラザホテル（新宿）
- Year and Date
  2015-07-23
- Data Source
  KAKENHI-PROJECT-26670895
[Presentation] レクチン様酸化LDL受容体-1(LOX-1)の破骨細胞形成と炎症性骨破壊に対する役割の解明2013
- Author(s)
  伊東順太、中谷地舞、林田千代美、岡安麻里、大山洋子、佐藤卓也、羽毛田慈之
- Organizer
  第55回歯科基礎医学会学術大会・総会
- Place of Presentation
  岡山コンベンションセンター、岡山、岡山県
- Data Source
  KAKENHI-PROJECT-25293376
[Presentation] Role of lectin-like oxidized low-density of lipoprotein receptor-1 in regulating osteoclastogenesis and inflammatory bone destruction.2013
- Author(s)
  Nakayachi M, Ito J, Okayasu M, Hayashida C, Sato T, Suda N, Sawamura T, Hakeda
- Organizer
  2nd Joint Meeting of the International Bone and Mineral Society and the Japanese Society for Bone and Mineral Research
- Place of Presentation
  Kobe Convention Center and Kobe Portpia Hotel, Kobe, Japan
- Data Source
  KAKENHI-PROJECT-25293376
[Presentation] Lectin-like oxidized low-density of lipoprotein receptor-1 is involved in RANKL-production elevated by lipopolysaccharide-injection on mouse calvaria and thereby contributes to inflammatory bone destruction2013
- Author(s)
  Nakayachi M, Ito J, Okayasu M, Hayashida C, Sato T, Suda N, Sawamura T, Hakeda Y.
- Organizer
  35th Annual Meeting of the American Society for Bone and Mineral Research
- Place of Presentation
  Baltimore Convention Center, Baltimore, Maryland, USA
- Data Source
  KAKENHI-PROJECT-25293376
[Presentation] レクチン様酸化LDL受容体-１（LOX-1）の破骨細胞形成および炎症性骨吸収に果たす役割の解明2013
- Author(s)
  中谷地舞、伊東順太、岡安麻里、須田直人、羽毛田慈之
- Organizer
  第72回日本矯正歯科学会大会
- Place of Presentation
  キッセイ文化ホール・松本市総合体育館、松本、長野県
- Data Source
  KAKENHI-PROJECT-25293376
[Presentation] マウス長骨からの骨細胞の分離方法の検討2011
- Author(s)
  林田千代美, 佐藤卓也, 中谷地舞, 伊東順太, 岡安麻里, 羽毛田慈之
- Organizer
  第54回歯科基礎医学会学術大会
- Place of Presentation
  岐阜
- Data Source
  KAKENHI-PROJECT-21592341
[Presentation] Exogenous Cholesterol, and Deficiency of LowDensity Lipoprotein Receptor in Mice CausesImpaired Osteoclastic Cell Fusion and Increase in Bone Mass2011
- Author(s)
  Okayasu M, Hayashida C, Nakayachi M, Sato T, Ito J, Suda N, Hakeda Y
- Organizer
  ASBMR 2011 Annual Meeting
- Place of Presentation
  SanDiego, California, USA
- Data Source
  KAKENHI-PROJECT-21592341
[Presentation] 株化骨細胞MLO-Y4はOPG以外の液性の破骨細胞形成抑制性因子を産生する2011
- Author(s)
  林田千代美, 佐藤卓也, 岡安麻里, 中谷地舞, 伊藤順太, 羽毛田慈之
- Organizer
  第23回日本骨代謝学会学術集会
- Place of Presentation
  大阪国際会議場(大阪府)
- Data Source
  KAKENHI-PROJECT-21592341
[Presentation] Low Density Lipoprotein Receptor欠損マウス(LDLR-KO)における破骨細胞融合障害と骨量増加2011
- Author(s)
  岡安麻里, 林田千代美, 中谷地舞, 鐘ヶ江晴秀, 須田直人, 羽毛田慈之
- Organizer
  第70回日本矯正歯科学会大会 & 第4回国際会議
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-21592341
[Presentation] 破骨細胞分化過程における細胞内cholesterol減少は, Atp6v0d2を介する細胞融合を抑制し骨量を増加する2011
- Author(s)
  岡安麻里, 林田千代美, 中谷地舞, 佐藤卓也, 伊東順太, 須田直人, 羽毛田慈之
- Organizer
  第54回歯科基礎医学会学術大会
- Place of Presentation
  岐阜
- Data Source
  KAKENHI-PROJECT-21592341
[Presentation] 破骨細胞分化は細胞外cholesterolに依存し, low density lipoprotein receptor欠損マウスは破骨細胞の融合障害に起因した骨量増加をみる2011
- Author(s)
  岡安麻里, 林田千代美, 中谷地舞, 佐藤卓也, 伊東順太, 須田直人, 羽毛田慈之
- Organizer
  第23回日本骨代謝学会学術集会
- Place of Presentation
  大阪国際会議場(大阪府)
- Data Source
  KAKENHI-PROJECT-21592341
[Presentation] Osteocytic MLO-Y4 cells inhibit osteoclastogenesis by a soluble factor(s), independent of modulation of RANKL/OPG productions by stromal cells2010
- Author(s)
  羽毛田慈之
- Organizer
  2010 Annual Meeting of American Society of Bone and Mineral Research
- Place of Presentation
  Toronto, Canada
- Data Source
  KAKENHI-PROJECT-21592341
[Presentation] Highly-requirement of exogenous cholesterol and positive role of lipid raft for osteoclast differentiation2010
- Author(s)
  羽毛田慈之
- Organizer
  2010 Annual Meeting of American Society of Bone and Mineral Research
- Place of Presentation
  Toronto, Canada
- Data Source
  KAKENHI-PROJECT-21592341
[Presentation] 破骨細胞形成における骨細胞の影響を分析可能な三次元重層培養系の開発2010
- Author(s)
  羽毛田慈之
- Organizer
  第52回歯科基礎医学会学術大会・総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21592341
[Presentation] 破骨細胞分化におけるRANKLに依存して発現するcaveolin-1とlipid/raftの役割2008
- Author(s)
  羽毛田慈之, 他7名
- Organizer
  第26回日本骨代謝学会
- Place of Presentation
  大阪
- Year and Date
  2008-10-29
- Data Source
  KAKENHI-PROJECT-19592130
[Presentation] 破骨細胞分化に対するLipid/raftの役割2007
- Author(s)
  羽毛田慈之, 他3名
- Organizer
  第49回歯科基礎医学会学術大会
- Place of Presentation
  札幌
- Year and Date
  2007-08-30
- Data Source
  KAKENHI-PROJECT-19592130
[Presentation] レクチン様酸化LDL受容体-1 (LOX-1)欠損マウスは骨量を減少させるが炎症性骨吸収に抵抗を示す
- Author(s)
  中谷地舞、伊東順太、岡安麻里、須田直人、羽毛田慈之
- Organizer
  第73回日本矯正歯科学会大会・第5回日韓ジョイントミーティング
- Place of Presentation
  幕張
- Year and Date
  2014-10-20 – 2014-10-22
- Data Source
  KAKENHI-PROJECT-26670895
[Presentation] レクチン様酸化LDL受容体-1 (LOX-1)欠損マウスは骨量を減少させるが炎症性骨吸収に抵抗を示す
- Author(s)
  中谷地舞, 伊東順太, 岡安麻里, 須田直人, 羽毛田慈之
- Organizer
  第74回日本矯正歯科学会大会・第5回日韓ジョイントミーティンク
- Place of Presentation
  幕張
- Year and Date
  2014-10-20 – 2014-10-22
- Data Source
  KAKENHI-PROJECT-25293376
[Presentation] レクチン様酸化LDL受容体-1 (LOX-1)欠損は定常状態における破骨細胞形成を促進するが、LPS誘導炎症性骨破壊に抵抗性を示す
- Author(s)
  伊東順太、林田千代美、大山洋子、佐藤卓也、羽毛田慈之
- Organizer
  第33回日本骨代謝学会学術集会
- Place of Presentation
  東京
- Year and Date
  2015-07-23 – 2015-07-25
- Data Source
  KAKENHI-PROJECT-25293376
[Presentation] レクチン様酸化LDL受容体-1 (LOX-1)欠損は定常状態における破骨細胞形成を促進するが、LPS誘導炎症性骨破壊に抵抗性を示す
- Author(s)
  伊東順太、林田千代美、大山洋子、佐藤卓也、羽毛田慈之
- Organizer
  第33回日本骨代謝学会学術集会
- Place of Presentation
  東京
- Year and Date
  2015-07-23 – 2015-07-25
- Data Source
  KAKENHI-PROJECT-26670895

1. KUMEGAWA Masayoshi (40049367)

# of Collaborated Projects: 9 results

# of Collaborated Products: 0 results
2. SATO Takuya (00316689)

# of Collaborated Projects: 6 results

# of Collaborated Products: 19 results
3. MASUHARA Masaaki (70372901)

# of Collaborated Projects: 4 results

# of Collaborated Products: 5 results
4. OKAYASU Mari (10610941)

# of Collaborated Projects: 4 results

# of Collaborated Products: 7 results
5. OGASAWARA Toru (20359623)

# of Collaborated Projects: 4 results

# of Collaborated Products: 1 results
6. MANO Hiroshi (20265359)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
7. KANEDA Toshio (70339521)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
8. TEZUKA Kenichi (50236973)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. YANO Fumiko (80529040)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. SAWAMURA Tatsuya (30243033)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
11. ITO Junta (40609096)

# of Collaborated Projects: 2 results

# of Collaborated Products: 11 results
12. ARAKAWA Toshiya (40306254)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
13. TAKUMA Taishin (40095336)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
14. SHIMOJIMA Takahiro (60146230)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
15. 森良之 (70251296)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
16. 緒方直史 (10361495)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
17. 阿部雅修 (10392333)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
18. 筑田博隆 (30345219)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
19. 茂呂徹 (20302698)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
20. SUSAMI Takafumi (80179184)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. NAGAHAMA Kohei (80587775)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. HAYASHIDA Chiyomi (40710900)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
23. SHIN Kitetsu (40187555)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. NAKAHARA Hiroshi (70049344)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. SUDA Toshio (60118453)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. NOBUMICHI Hozumi (60051744)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. KURIHARA Eiko (40112643)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. MAEDA Norihiko (60049418)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. IKEDA Katsumi (50049350)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. 栗橋徳善 (10186512)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. 森芳史 (60757954)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. 藤原夕子 (50466744)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. 虻川東嗣 (50453717)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
34. 須田直人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HAKEDA Yoshiyuki 羽毛田 慈之

羽毛田 慈之 ハケダ ヨシユキ

羽毛田 慈行 ハケダ ヨシユキ

Research Projects

Research Products

Co-Researchers

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of Involvement of LOX-1 in inflammatory bone destruction and the molecular mechanism for the LOX-1 actions, and an approach to develop the new drug for bone diseases.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Trial study for the establishment of the new therapeutical method for periodontal disease that targets oxidation LDL receptor LOX-1.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The elucidation of the role of lipid in bone resorption of inflammatory bone diseases; in particular, the exploration of the role of LOX-1 as an oxidized LDL receptorPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

DEPENDENCY OF OSTEOCLAST DIFFERENTIATION ON EXOGENOUS CHOLESTEROL AND ROLE OF CAVEOLIN-1 IN OSTEOCLASTOGENESISPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation on roles of caveolae/lipid raft on osteoclast differentiation and bone resorption and on intracellular trafficking of caveolin-1Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation of action of shear stress, which is produced by Mechanical loading applied to the skeleton, on osteodast formation and bone-resorbing activityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of role of beta ig-3 derived from osteoclasts in bone resorption and formationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

HAKEDA Yoshiyuki 羽毛田慈之

羽毛田慈之ハケダヨシユキ

羽毛田慈行ハケダヨシユキ