OKADA TAKASHI 岡田尚巳

… Alternative Names

OKADA Takashi 岡田尚巳

岡田尚已オカダタカシ

OKADA Tadashi 岡田尚史

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Researcher Number	00326828
Other IDs	https://orcid.org/0000-0002-2910-3797
Affiliation (Current)	2025: 東京大学, 医科学研究所, 教授
Affiliation (based on the past Project Information) *help	2020 – 2024: 東京大学, 医科学研究所, 教授 2016 – 2019: 日本医科大学, 大学院医学研究科, 大学院教授 2014 – 2016: 日本医科大学, 医学(系)研究科(研究院), 教授 2014: 日本医科大学, 大学院医学研究科, 大学院教授 2014: 日本医科大学, 大学院医学研究科, 教授 … More 2013: 独立行政法人国立精神・神経医療研究センター, 神経研究所・遺伝子疾患研究部, 室長 2012 – 2013: 独立行政法人国立精神・神経医療研究センター, 神経研究所遺伝子疾患治療研究部, 室長 2012 – 2013: 独立行政法人国立精神・神経医療研究センター, 神経研究所遺伝子疾患治療研究部, 室長 2012: 国立精神・神経医療研究センター, 神経研究所, 室長 2012: 独立行政法人国立精神・神経医療研究センター, 神経研究所・遺伝子疾患治療研究部遺伝子治療技術開発室, 室長 2009 – 2011: National Center of Neurology and Psychiatry, 神経研究所・遺伝子疾患治療研究部, 室長 2009: National Center of Neurology and Psychiatry, 神経研究所・遺伝子疾患治療研究部, 室長 2009: National Center of Neurology and Psychiatry, 神経研究所遺伝子疾患治療研究部, 室長 2009: 自治医科大学, 医学部, 講師 2008: National Center of Neurology and Psychiatry, 神経研究所遺伝子疾患治療研究部, 室長 2008: National Center of Neurology and Psychiatry, 神経研究所遺伝子疾病治療研究部, 室長 2007: National Center of Neurology and Psychiatry, 神経研究所・遺伝子疾患治療研究部, 室長 2006: National Institute of Neuroscience, National Center of Neurology and Psychiatry, Section Chief, 神経研究所遺伝子疾患治療研究部, 室長 2006: 国立精神・神経センター, 神経研究所遺伝子疾患治療研究部, 室長 2004 – 2006: 自治医科大学, 医学部, 講師 2000 – 2003: 自治医科大学, 医学部, 助手 2002: 自治医科大学, 助手 Less
Review Section/Research Field	Principal Investigator Cerebral neurosurgery / Basic Section 56010:Neurosurgery-related / Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields / Applied molecular and cellular biology / Neurosurgery / Applied pharmacology / Laboratory medicine / Cerebral neurosurgery / Biological Sciences Except Principal Investigator Hematology … More / Fusional basic brain science / Basic Section 52050:Embryonic medicine and pediatrics-related / Laboratory animal science / Pediatrics / Cerebral neurosurgery / Neurology / Laboratory animal science / Biological Sciences Less
Keywords	Principal Investigator 遺伝子治療 / 脳神経疾患 / アデノウイルス / AAV / バイオテクノロジー / 遺伝子 / ウイルス / AAVベクター / 幹細胞 / アデノ随伴ウイルス … More / 遺伝子細胞治療 / 脳腫瘍 / 神経疾患 / レトロウイルス / ハイブリッドベクター / ウイルスベクター / 遺伝子細胞療法 / MSC / TR / LAT / 遺伝子編集 / CRISPR-Cas9 / 脊髄小脳変性症６型 / CRISPR-dCas9 / 脊髄小脳変性症 / ヘルペスウイルス / CACNA1A / CRISPRi / 脊髄小脳失調症 / SCA6 / CRISPR-Cas / HSVベクター / biotechnology / neuronal diseases / virus / gene / IL-10 / 動脈硬化症 / 脳血管障害 / アデノ随判ウイルス / ウィルスベクター / 腫瘍 / ベクター / 脳梗塞 / 間葉系幹細胞 / DMD / 細胞 / ゲノム / 細胞治療 / 遺伝性神経筋疾患 / 遺伝子修正 / SP細胞 / 神経膠腫 / がん幹細胞 / 遺伝子導入 / 神経成長因子 / 神経筋疾患 / 染色体遺伝子組込み / c-Kit / CAR / アデノウイルスベクター / AAVS1 / Rep / 染色体部位特異的遺伝子組込み / Bim / アポトーシス / HSV-tk / 悪性神経膠腫 / Cre-loxP / ハイブリッドウイルスベクター / 遺伝子発現制御 / 自殺遺伝子治療 / がん … More Except Principal Investigator AAVベクター / 遺伝子治療 / アデノウイルスベクター / ITR / Rep / macrophage / NK / MCP-1 / Vaccine / Glioma / 疾患モデル / 遺伝子導入 / 霊長類 / 組織特異性 / 包括的病態解析 / iPS細胞 / マウスモデル / デルマタン硫酸 / 筋拘縮型エーラス・ダンロス症候群 / 成体 / 血液脳関門 / 超音波 / マーモセット / てんかん / Pituitary / Hypothalamus / Adenovirus vector / Gene therapy / CAH / ACTH / 21水酸化酵素 / 下垂体 / 視床下部 / 先天性副腎過形成 / adaptor molecule / adenoviral vector / targeted vector integration / protein-supplement gene therapy / tissue specificity / AAV vector / TVI法 / AAVS1領域 / 血清型 / 免疫反応 / 凝固因子 / エリスロポエチン / アダプター分子 / 染色体部位特異的遺伝子組込み / 蛋白質補充遺伝子療法 / Bim / Gl10ma / selective amplifier gene / chronic granulomatous disease / hematopoietic stem cells / gene therapy / レトロウイルスベクター / 選択的増幅遺伝子 / 慢性肉芽腫症 / 造血幹細胞 / アンチセンス・オリゴヌクリオチド / デュシェンヌ型筋ジストロフィー / デュシェンヌ型筋ジストロフィー / アデノ随伴ベクター / アンチセンス・オリゴヌクレオチド / トランスレーショナルリサーチ / エクソン・スキップ / アミロイドβ蛋白 / カニクイザル / アデノ随伴ウイルス / アミロイドβ / アルツハイマー病 / 神経科学 / 大脳皮質 / 運動野 / 高性能レーザー / 脳・神経 / 連合記憶 / 線条体 / 視覚野 / 記憶システム / 内側側頭葉 / 長期記憶 / 皮質脳波 / 光脳科学 / ウイルスベクター / 担癌ヌードマウス / ヒストン脱アセチル化酵素阻害剤 / リンパ行性転移抑制 / 抗腫瘍血管遺伝子療法 / VEGF-C / sFlt-4 / sFlt-1 / リンパ管新生 / 血管新生 / バキュロウイルス / がん遺伝子治療 / バイオテクノロジー / 癌 / ウイルス / 遺伝子 Less

アデノ随伴ウイルスベクター基盤技術開発と脳神経疾患に対する遺伝子細胞療法Principal Investigator
- Principal Investigator
  
  岡田尚巳
- Project Period (FY)
  2024 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
- Research Institution
  The University of Tokyo
アデノ随伴ウイルスベクター基盤技術開発と脳神経疾患に対する遺伝子細胞療法Principal Investigator
- Principal Investigator
  
  岡田尚巳
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  The University of Tokyo
Integrated understanding of dermatan sulfate through uncovering pathophysiology of musculocontractural Ehlers-Danlos syndrome
- Principal Investigator
  
  Kosho Tomoki
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Shinshu University
LATmiRNAPrincipal Investigator
- Principal Investigator
  
  Okada Takashi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Applied molecular and cellular biology
- Research Institution
  Nippon Medical School
AAV vector-mediated cell and gene therapy for neuronal diseasePrincipal Investigator
- Principal Investigator
  
  Okada Takashi
- Project Period (FY)
  2014 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurosurgery
- Research Institution
  Nippon Medical School
Development of rAAV-mediated brain transduction with transient ultrasound-mediated modulation of the blood-brain interface in adult common marmoset toward modeling epilepsy
- Principal Investigator
  
  Okada Hironori
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory animal science
- Research Institution
  Nippon Medical School
Development of AAV-induced exonskipping therapy for Duchenne muscular dystrophy
- Principal Investigator
  
  Nagata Tetsuya
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  National Center of Neurology and Psychiatry
Gene correction therapy by homologous recombinationPrincipal Investigator
- Principal Investigator
  
  OKADA Takashi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Applied pharmacology
- Research Institution
  Nippon Medical School
  独立行政法人国立精神・神経医療研究センター
Systematic functional mapping of synaptic connections between cerebral cortical areas
- Principal Investigator
  
  MATSUZAKI Masanori
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Fusional basic brain science
- Research Institution
  National Institute for Basic Biology
Model animals by nonhuman primate for Alzheimer disease, hyper expression of mutant amyloid precursor protein and formation of senile plaques in the brain
- Principal Investigator
  
  NAKAMURA Shinichiro
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Laboratory animal science
- Research Institution
  Shiga University of Medical Science
AAV vector-mediated cell and gene therapy for neuronal diseasesPrincipal Investigator
- Principal Investigator
  
  OKADA Takashi
- Project Period (FY)
  2010 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  National Center of Neurology and Psychiatry
Optogenetic control of macaque temporal neurons
- Principal Investigator
  
  NAKAHARA Kiyoshi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Fusional basic brain science
- Research Institution
  Niigata University
  National Center of Neurology and Psychiatry
AAV vector-mediated cell and gene therapy for neuronal diseasesPrincipal Investigator
- Principal Investigator
  
  OKADA Takashi
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  National Center of Neurology and Psychiatry
糖鎖情報を利用したがん幹細胞マーカーの探索と腫瘍標的システムPrincipal Investigator
- Principal Investigator
  
  岡田尚巳
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Laboratory medicine
- Research Institution
  National Center of Neurology and Psychiatry
Development of AAV (adeno-associated virus) vectors and their application to cancer therapy
- Principal Investigator
  
  OZAWA Keiya
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Jichi Medical University
Gene therapy for neuronal diseases using rAAVPrincipal Investigator
- Principal Investigator
  
  OKADA Takashi
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  National Institute of Neuroscience, National Center of Neurology and Psychiatry
  Jichi Medical University
神経幹細胞への染色体部位特異的遺伝子組込み法の開発Principal Investigator
- Principal Investigator
  
  岡田尚已
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Jichi Medical University
Development of basic technologies for gene therapy using adeno-associated virus (AAV)
- Principal Investigator
  
  OZAWA Kaiya
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  Jichi Medical School
Analysis of gene therapy and its effect to hypothalamic-pituitary-adrenal axis
- Principal Investigator
  
  TAJIMA Toshihiro
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  HOKKAIDO UNIVERSITY
腫瘍選択的増幅型ハイブリッドウイルスベクターの開発とその制御機構の解明Principal Investigator
- Principal Investigator
  
  岡田尚已 (岡田尚巳)
- Project Period (FY)
  2001 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Jichi Medical University
悪性神経膠腫に対する腫瘍特異的増幅型ハイブリッドベクターを用いた遺伝子治療Principal Investigator
- Principal Investigator
  
  岡田尚巳 (岡田尚已)
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Jichi Medical University
Research for genetic enhanced immunotherapy to the human malignant glioma.
- Principal Investigator
  
  NAGAI Mutsumi
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Jichi Medical School
Gene transfer into hematopoietic stem cells and gene therapy for chronic granulomatous disease
- Principal Investigator
  
  KUME Akihiro
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  Jichi Medical School

[Book] 「筋ジストロフィー症」遺伝子治療開発研究ハンドブック　第2版2023
- Author(s)
  喜納裕美、岡田尚巳
- Total Pages
  772
- Publisher
  (株)エヌ・ティー・エス
- ISBN
  9784860438401
- Data Source
  KAKENHI-PROJECT-23K20328
[Book] 遺伝子治療用ベクター・細胞の製造状況遺伝子治療開発研究ハンドブック　第2版2023
- Author(s)
  岡田尚巳
- Total Pages
  772
- Publisher
  (株)エヌ・ティー・エス
- Data Source
  KAKENHI-PROJECT-23K20328
[Book] PHARM STAGE2016
- Author(s)
  伴野太郎、岡田尚巳
- Total Pages
  13
- Publisher
  技術情報協会
- Data Source
  KAKENHI-PROJECT-26293328
[Book] 遺伝子医学MOOK 今着実に実り始めた遺伝子治療～最新研究と今後の展開(分担執筆)2016
- Author(s)
  岡田尚巳、武田伸一
- Total Pages
  200
- Publisher
  メディカルドゥ
- Data Source
  KAKENHI-PROJECT-26293328
[Book] 血液フロンティア　25巻5号ゲノム編集技術を用いる遺伝子治療(分担執筆)2015
- Author(s)
  岡田浩典、伴野太郎、岡田尚巳
- Total Pages
  140
- Publisher
  医薬ジャーナル社
- Data Source
  KAKENHI-PROJECT-26293328
[Book] 血液フロンティア: ゲノム編集技術を用いる遺伝子治療2015
- Author(s)
  岡田浩典、伴野太郎、岡田尚巳
- Total Pages
  16
- Publisher
  医薬ジャーナル社
- Data Source
  KAKENHI-PROJECT-26430102
[Book] Phama Medica　33巻4号遺伝子導入用ウイルスベクターの特徴と作成法(分担執筆)2015
- Author(s)
  伴野太郎、岡田浩典、岡田尚巳
- Total Pages
  140
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-26293328
[Book] Pharma Medica: 遺伝子導入用ウイルスベクターの特徴と作成法2015
- Author(s)
  伴野太郎、岡田浩典、岡田尚巳
- Total Pages
  8
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-26430102
[Book] Gene Therapy - Tools and Potential Applications2013
- Author(s)
  Okada, T.
- Total Pages
  744
- Publisher
  InTech
- Data Source
  KAKENHI-PROJECT-22390284
[Book] Efficient AAV vector production system: Towards gene therapy for Duchenne muscular dystrophy2013
- Author(s)
  Takashi Okada
- Total Pages
  21
- Publisher
  InTech
- Data Source
  KAKENHI-PROJECT-22390284
[Book] BIO Clinica2011
- Author(s)
  岡田尚巳
- Publisher
  筋疾患の遺伝子治療
- Data Source
  KAKENHI-PROJECT-22390284
[Book] Progress and Challenges in AAV-Mediated Gene Therapy for Duchenne Muscular Dystrophy2011
- Author(s)
  Okada T, et.al.
- Publisher
  Viral Gene Therapy (ed.by Ke Xu), InTech
- Data Source
  KAKENHI-PROJECT-22390284
[Book] Gene Therapy and Regulation(ed.by Roger.Bertolotti)2010
- Author(s)
  Okada T, et.al.
- Publisher
  Advances in molecular therapy research on dystrophin-deficient muscular dystrophy.
- Data Source
  KAKENHI-PROJECT-22390284
[Book] Gene therapy for Duchenne muscular dystrophy.In, A Guide to Human Gene Therapy2010
- Author(s)
  Okada T, et al.
- Publisher
  World Scientific, NJ(in press)
- Data Source
  KAKENHI-PROJECT-19390383
[Book] Gene therapy for Duchenne muscular dystrophy. In A Guide to Human Gene Therapy2009
- Author(s)
  Okada, T., et al.
- Publisher
  World Scientific, NJ. (in press)
- Data Source
  KAKENHI-PROJECT-19390383
[Book] Gene Therapy and Cancer Research Focus. (ed. by R. N. Campbell)2008
- Author(s)
  Okada, T.
- Publisher
  Nova Science Publishers, Inc
- Data Source
  KAKENHI-PROJECT-19390383
[Book] Vector-producing mesenchymal stem cells for cancer gene therapy.In: Gene Therapy and Cancer Research Focus2008
- Author(s)
  Okada, T., et. al.
- Publisher
  Nova Science Publishers,Inc(in press)
- Data Source
  KAKENHI-PROJECT-19659144
[Book] 癌幹細胞の同定法、がんの浸潤・転移研究ハンドブック2008
- Author(s)
  岡田尚巳
- Publisher
  金芳堂(in press)
- Data Source
  KAKENHI-PROJECT-19659144
[Book] Adeno-associated viral vector-mediated gene therapy of ischemia-induced neuronal death (ed.by M.Ian Phillips)2002
- Author(s)
  Okada, T., et al.
- Publisher
  Academic Press
- Data Source
  KAKENHI-PROJECT-13218116
[Book] A Guide to Human Gene Therapy (ed. by Roland W. Herzog and Sergei Zolotukhin)
- Author(s)
  Okada T, Takeda S
- Publisher
  World Scientific(in press)
- Data Source
  KAKENHI-PROJECT-19390383
[Book] A Guide to Human Gene Therapy(ed. by Roland W.Herzog and Sergei Zolotukhin)(Gene therapy for Duchenne muscular dystrophy.)
- Author(s)
  Okada T, Takeda S
- Publisher
  World Scientific, NJ.(in press)
- Data Source
  KAKENHI-PROJECT-19390383
[Book] Gene Therapy and Regulation (ed. by Roger. Bertolotti)
- Author(s)
  Okada, T., Takeda, S.
- Publisher
  World Scientific(in press)
- Data Source
  KAKENHI-PROJECT-19390383
[Book] A Guide to Human Gene Therapy(ed.by Roland W.Herzog, Sergei Zolotukhin)
- Author(s)
  Okada T, et.al.
- Publisher
  Gene therapy for Duchenne muscular dystrophy in press
- Data Source
  KAKENHI-PROJECT-22390284
[Journal Article] Large-scale purification of functional AAV particles packaging the full genome using short-term ultracentrifugation with a zonal rotor2023
- Author(s)
  Wada M, Uchida N, Posadas-Herrera G, Hayashita-Kinoh H, Tsunekawa Y, Hirai Y, Okada T.
- Journal Title
  
  Gene Therapy
  
  Volume: Mar 28 Issue: 7-8 Pages: 641-648
- DOI
  10.1038/s41434-023-00398-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K20328, KAKENHI-PROJECT-22K06064, KAKENHI-PROJECT-20K06464
[Journal Article] LONRF2 is a protein quality control ubiquitin ligase whose deficiency causes late-onset neurological deficits2023
- Author(s)
  Li Dan、Johmura Yoshikazu、Morimoto Satoru et al.
- Journal Title
  
  Nature Aging
  
  Volume: 3 Issue: 8 Pages: 1001-1019
- DOI
  10.1038/s43587-023-00464-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15736, KAKENHI-PROJECT-23K07345, KAKENHI-PROJECT-19K08267, KAKENHI-PROJECT-20K06464, KAKENHI-PROJECT-21K07411, KAKENHI-PROJECT-22K19398, KAKENHI-PROJECT-22K15724, KAKENHI-PROJECT-20H03162, KAKENHI-ORGANIZER-19H05739, KAKENHI-PLANNED-21H05278, KAKENHI-ORGANIZER-23H03834, KAKENHI-PLANNED-23H03835, KAKENHI-PROJECT-20H00485, KAKENHI-PROJECT-23K20328, KAKENHI-PROJECT-23K27084, KAKENHI-PROJECT-23K27376
[Journal Article] Neat1 lncRNA organizes the inflammatory gene expressions in the dorsal root ganglion in neuropathic pain caused by nerve injury2023
- Author(s)
  Maruyama Motoyo、Sakai Atsushi、Fukunaga Tsukasa、Miyagawa Yoshitaka、Okada Takashi、Hamada Michiaki、Suzuki Hidenori
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 14 Pages: 1185322-1185322
- DOI
  10.3389/fimmu.2023.1185322
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19463, KAKENHI-PROJECT-23K08415, KAKENHI-PROJECT-21K08936, KAKENHI-PROJECT-23K20328, KAKENHI-PROJECT-23K27493
[Journal Article] Development of a novel purification method for AAV vectors using tangential flow filtration2023
- Author(s)
  Miyaoka Rimi、Tsunekawa Yuji、Kurosawa Yae、Sasaki Takako、Onodera Azusa、Sakamoto Kenji、Kakiuchi Yuko、Wada Mikako、Nitahara‐Kasahara Yuko、Hayashita‐Kinoh Hiromi、Okada Takashi
- Journal Title
  
  Biotechnology and Bioengineering
  
  Volume: 120 Issue: 11 Pages: 3311-3321
- DOI
  10.1002/bit.28524
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06064, KAKENHI-PROJECT-22K06921, KAKENHI-PROJECT-20K06464, KAKENHI-PROJECT-23K20328
[Journal Article] Engineering a highly durable adeno-associated virus receptor for analytical applications2023
- Author(s)
  Yoshida Kouhei、Tsunekawa Yuji、Kurihara Kento、Watanabe Kazuya、Makino-Manabe Yuriko、Wada Mikako、Tanaka Toru、Ide Teruhiko、Okada Takashi
- Journal Title
  
  Molecular Therapy - Methods & Clinical Development
  
  Volume: 31 Pages: 101157-101157
- DOI
  10.1016/j.omtm.2023.101157
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06464, KAKENHI-PROJECT-23K20328
[Journal Article] Immunomodulatory amnion mesenchymal stromal cells preserve muscle function in a mouse model of Duchenne muscular dystrophy.2023
- Author(s)
  Yuko Nitahara-Kasahara, Soya Nakayama, Koichi Kimura, Sho Yamaguchi, Yuko Kakiuchi, Chikako Nito, Masahiro Hayashi, Tomoyuki Nakaishi, Yasuyoshi Ueda, and Takashi Okada.
- Journal Title
  
  Stem Cell Research & Therapy
  
  Volume: - Issue: 1 Pages: 108-108
- DOI
  10.1186/s13287-023-03337-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06921, KAKENHI-PROJECT-22K18345, KAKENHI-PROJECT-23K06905, KAKENHI-PROJECT-23K20328
[Journal Article] Therapeutic Application of Extracellular Vesicles-Capsulated Adeno-Associated Virus Vector via nSMase2/Smpd3, Satellite, and Immune Cells in Duchenne Muscular Dystrophy2022
- Author(s)
  Matsuzaka Yasunari、Hirai Yukihiko、Hashido Kazuo、Okada Takashi
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 3 Pages: 1551-1551
- DOI
  10.3390/ijms23031551
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K20328
[Journal Article] Use of Mesenchymal Stem Cells to Enhance the Efficacy of Gene Therapy2022
- Author(s)
  Hiromi Hayashita-Kinoh, Takashi Okada
- Journal Title
  
  Methods Mol Biol.
  
  Volume: 2587 Pages: 377-386
- DOI
  10.1007/978-1-0716-2772-3_19
- ISBN
  9781071627716, 9781071627723
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K12779, KAKENHI-PROJECT-23K20328, KAKENHI-PROJECT-22K06064
[Journal Article] CDP-ribitol prodrug treatment ameliorates ISPD-deficient muscular dystrophy mouse model2022
- Author(s)
  Tokuoka Hideki、Imae Rieko、Nakashima Hitomi、Manya Hiroshi、Masuda Chiaki、Hoshino Shunsuke、Kobayashi Kazuhiro、Lefeber Dirk J.、Matsumoto Riki、Okada Takashi、Endo Tamao、Kanagawa Motoi、Toda Tatsushi
- Journal Title
  
  Nature Communications
  
  Volume: 13 Issue: 1 Pages: 1847-1847
- DOI
  10.1038/s41467-022-29473-4
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03987, KAKENHI-PROJECT-22K19509, KAKENHI-PROJECT-20H00526, KAKENHI-PROJECT-21H02685, KAKENHI-PROJECT-19K07058, KAKENHI-WRAPUP-22H04899, KAKENHI-PROJECT-23K20328, KAKENHI-PROJECT-19H05648, KAKENHI-PROJECT-23K24244
[Journal Article] CRISPR/Cas9 and AAV mediated insertion of β2 microglobulin-HLA-G fusion gene protects mesenchymal stromal cells from allogeneic rejection and potentiates the use for off-the-shelf cell therapy2022
- Author(s)
  Meshitsuka Sohsuke、Ninomiya Ryo、Nagamura-Inoue Tokiko、Okada Takashi、Futami Muneyoshi、Tojo Arinobu
- Journal Title
  
  Regenerative Therapy
  
  Volume: 21 Pages: 442-452
- DOI
  10.1016/j.reth.2022.09.009
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K10212, KAKENHI-PROJECT-23K20328
[Journal Article] Dental-Pulp Stem Cells as a Therapeutic Strategy for Ischemic Stroke2022
- Author(s)
  Nito Chikako、Suda Satoshi、Nitahara-Kasahara Yuko、Okada Takashi、Kimura Kazumi
- Journal Title
  
  Biomedicines
  
  Volume: 10 Issue: 4 Pages: 737-737
- DOI
  10.3390/biomedicines10040737
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08981, KAKENHI-PROJECT-19K09492, KAKENHI-PROJECT-23K20328
[Journal Article] A PCR-amplified transgene fragment flanked by a single copy of a truncated inverted terminal repeat for recombinant adeno-associated virus production prevents unnecessary plasmid DNA packaging2021
- Author(s)
  Adachi Kumi、Tomono Taro、Okada Hironori、Shiozawa Yusuke、Yamamoto Motoko、Miyagawa Yoshitaka、Okada Takashi
- Journal Title
  
  Gene Therapy
  
  Volume: - Issue: 7-8 Pages: 449-457
- DOI
  10.1038/s41434-021-00299-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22505, KAKENHI-PROJECT-21H03828, KAKENHI-PROJECT-23K20328
[Journal Article] Brain-derived Neurotrophic Factor in the Aqueous Humor of Glaucoma Patients2021
- Author(s)
  Igarashi Tsutomu、Nakamoto Kenji、Kobayashi Maika、Suzuki Hisaharu、Arima Takeshi、Tobita Yutaro、Takao Kazuhiro、Igarashi Toru、Okuda Takahisa、Okada Takashi、Takahashi Hiroshi
- Journal Title
  
  Journal of Nippon Medical School
  
  Volume: 88 Issue: 2 Pages: 128-132
- DOI
  10.1272/jnms.JNMS.2021_88-305
- NAID
  130008037216
- ISSN
  1345-4676, 1347-3409
- Year and Date
  2021-04-24
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H04038, KAKENHI-PROJECT-23K20328
[Journal Article] Myopathy associated with dermatan sulfate-deficient decorin and myostatin in musculocontractural Ehlers-Danlos syndrome: a mouse model investigation2021
- Author(s)
  Yuko Nitahara-Kasahara, Guillermo Posadas-Herrera, Shuji Mizumoto, Aki Nakamura-Takahashi, Yukiko U. Inoue, Takayoshi Inoue, Yoshihiro Nomura, Shin’ichi Takeda, Shuhei Yamada, Tomoki Kosho, Takashi Okada
- Journal Title
  
  Frontiers in Cell and Developmental Biology
  
  Volume: 9 Pages: 695021-695021
- DOI
  10.3389/fcell.2021.695021
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07054, KAKENHI-PUBLICLY-19H04922, KAKENHI-PROJECT-19H03616, KAKENHI-PROJECT-20K06467
[Journal Article] Amount of Green Fluorescent Protein in the Anterior Chamber after Intravitreal Injection of Triple-Mutated Self-Complementary AAV2 Vectors is Not Affected by Previous Vitrectomy Surgery2021
- Author(s)
  Takahashi Kazuhisa、Igarashi Tsutomu、Miyake Koichi、Kobayashi Maika、Katakai Yuko、Hayashita-Kinoh Hiromi、Fujimoto Chiaki、Kameya Shuhei、Takahashi Hiroshi、Okada Takashi
- Journal Title
  
  Journal of Nippon Medical School
  
  Volume: 88 Issue: 2 Pages: 103-108
- DOI
  10.1272/jnms.JNMS.2021_88-203
- NAID
  130008037221
- ISSN
  1345-4676, 1347-3409
- Year and Date
  2021-04-24
- Language
  English
- Data Source
  KAKENHI-PROJECT-23K20328
[Journal Article] A new mouse model of Ehlers-Danlos syndrome generated using CRISPR/Cas9-mediated genomic editing.2021
- Author(s)
  Yuko Nitahara-Kasahara, Shuji Mizumoto, et al.
- Journal Title
  
  Disease Models & Mechanisms
  
  Volume: 14 Issue: 12
- DOI
  10.1242/dmm.048963
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07054, KAKENHI-PUBLICLY-19H04922, KAKENHI-PROJECT-19H03616, KAKENHI-PROJECT-19K08745, KAKENHI-PROJECT-20K06467
[Journal Article] Systematic investigation of the skin in Chst14－/－ mice: a model for skin fragility in musculocontractural Ehlers-Danlos syndrome caused by CHST14 variants (mcEDS-CHST14)2021
- Author(s)
  Takuya Hirose*, Shuji Mizumoto*, Ayana Hashimoto, Yuki Takahashi, Takahiro Yoshizawa, Yuko Nitahara-Kasahara, Naoki Takahashi, Jun Nakayama, Kazushige Takehana, Takashi Okada, Yoshihiro Nomura, Shuhei Yamada, Tomoki Kosho, Takafumi Watanabe (*equal contribution)
- Journal Title
  
  Glycobiology
  
  Volume: 31 Issue: 2 Pages: 137-150
- DOI
  10.1093/glycob/cwaa058
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07054, KAKENHI-PROJECT-19K08745, KAKENHI-PROJECT-19H03616
[Journal Article] Tyrosine triple mutated AAV2-BDNF gene therapy in an inner retinal injury model induced by intravitreal injection of N?methyl-D-aspartate (NMDA).2020
- Author(s)
  Shiozawa Lee A, Igarashi T, Kobayashi M, Nakamoto K, Kameya S, Fujishita S, Takahashi H, Okada T.
- Journal Title
  
  Mol Vision
  
  Volume: 26 Pages: 409-422
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K20328
[Journal Article] Aspects of Gene Therapy Products Using Current Genome-Editing Technology in Japan2020
- Author(s)
  Yamaguchi Teruhide、Uchida Eriko、Okada Takashi、Ozawa Keiya、Onodera Masafumi、Kume Akihiro、Shimada Takashi、Takahashi Satoru、Tani Kenzaburo、Nasu Yasutomo、Mashimo Tomoji、Mizuguchi Hiroyuki、Mitani Kohnosuke、Maki Kazushige
- Journal Title
  
  Human Gene Therapy
  
  Volume: 31 Issue: 19-20 Pages: 1043-1053
- DOI
  10.1089/hum.2020.156
- NAID
  120007147867
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H03974, KAKENHI-PROJECT-18K07853, KAKENHI-PROJECT-23K20328
[Journal Article] Backcrossing to an appropriate genetic background improves the birth rate of carbohydrate sulfotransferase 14 gene-deleted mice2020
- Author(s)
  SHIMADA Shin、YOSHIZAWA Takahiro、TAKAHASHI Yuki、NITAHARA-KASAHARA Yuko、OKADA Takashi、NOMURA Yoshihiro、YAMANAKA Hitoki、KOSHO Tomoki、MATSUMOTO Kiyoshi
- Journal Title
  
  Exp. Anim.
  
  Volume: 69 Issue: 4 Pages: 407-413
- DOI
  10.1538/expanim.19-0150
- NAID
  130007938664
- ISSN
  0007-5124, 1341-1357, 1881-7122
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08745, KAKENHI-PROJECT-19H03616, KAKENHI-PROJECT-18K06019
[Journal Article] High-Level Expression of Alkaline Phosphatase by Adeno-Associated Virus Vector Ameliorates Pathological Bone Structure in a Hypophosphatasia Mouse Model2020
- Author(s)
  Aki Nakamura-Takahashi , Toshiki Tanase, Satoru Matsunaga, Seikou Shintani, Shinichi Abe, Yuko Nitahara-Kasahara, Atsushi Watanabe, Yukihiko Hirai, Takashi Okada, Akira Yamaguchi, Masataka Kasahara
- Journal Title
  
  Calcified Tissue International
  
  Volume: 106 Issue: 6 Pages: 665-677
- DOI
  10.1007/s00223-020-00676-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K18970, KAKENHI-PROJECT-19H03833, KAKENHI-PROJECT-18K09643, KAKENHI-PROJECT-20H03894, KAKENHI-PROJECT-23K20328
[Journal Article] Improved transduction of canine　X-linked muscular dystrophy with rAAV9-microdystrophin via multipotent mesenchymal stromal cell pretreatment.2020
- Author(s)
  Hayashita-Kinoh H, Posadas-Herrera G, Nitahara-Kasahara Y, Kuraoka M,　Okada H, Chiyo T, Takeda S, Okada T.
- Journal Title
  
  Mol Ther Methods Clin Dev
  
  Volume: 20 Pages: 133-141
- DOI
  10.1016/j.omtm.2020.11.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K20328
[Journal Article] rAAV8 and rAAV9-mediated long-term muscle transduction with tacrolimus (FK506) in non-human primates.2020
- Author(s)
  Ishii A, Okada H, Hayashita-Kinoh H, Shin JH, Tamaoka A, Okada T, Takeda S.
- Journal Title
  
  Mol Ther Methods Clin Dev
  
  Volume: 18 Pages: 44-49
- DOI
  10.1016/j.omtm.2020.05.012
- NAID
  120007168386
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K20328
[Journal Article] Dorsal Root Ganglia Homeobox downregulation in primary sensory neurons contributes to neuropathic pain in rats.2020
- Author(s)
  Ito T, Sakai A, Maruyama M, Miyagawa Y, Okada T, Fukayama H, Suzuki H.
- Journal Title
  
  Molecular Pain
  
  Volume: 16 Pages: 1-11
- DOI
  10.1177/1744806920904462
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05461, KAKENHI-PROJECT-19H03552, KAKENHI-PROJECT-23K20328
[Journal Article] Serum Brain-Derived Neurotrophic Factor in Glaucoma Patients in Japan: An Observational Study2020
- Author(s)
  Tsutomu Igarashi , Kenji Nakamoto , Maika Kobayashi , Hisaharu Suzuki , Yutaro Tobita , Toru Igarashi , Takahisa Okuda , Takashi Okada , Hiroshi Takahashi
- Journal Title
  
  Journal of Nippon Medical School
  
  Volume: 87 Issue: 6 Pages: 339-345
- DOI
  10.1272/jnms.JNMS.2020_87-605
- NAID
  130007966496
- ISSN
  1345-4676, 1347-3409
- Year and Date
  2020-12-15
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H04038, KAKENHI-PROJECT-23K20328
[Journal Article] Hippocampal GAD67 Transduction Using rAAV8 Regulates Epileptogenesis in EL Mice2019
- Author(s)
  Shimazaki Kuniko、Kobari Takashi、Oguro Keiji、Yokota Hidenori、Kasahara Yuko、Murashima Yoshiya、Watanabe Eiju、Kawai Kensuke、Okada Takashi
- Journal Title
  
  Molecular Therapy - Methods & Clinical Development
  
  Volume: 13 Pages: 180-186
- DOI
  10.1016/j.omtm.2018.12.012
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26293328, KAKENHI-PROJECT-17H04305
[Journal Article] Transplantation of human dental pulp stem cells ameliorates brain damage following acute cerebral ischemia2018
- Author(s)
  Nito C, Sowa K, Nakajima M, Sakamoto Y, Suda S, Nishiyama Y, Nakamura-Takahashi A, Nitahara-Kasahara Y, Ueda M, Okada T, Kimura K
- Journal Title
  
  Biomed Pharmacother
  
  Volume: 108 Pages: 1005-1014
- DOI
  10.1016/j.biopha.2018.09.084
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K10742, KAKENHI-PROJECT-26293328
[Journal Article] Highly Efficient Ultracentrifugation-free Chromatographic Purification of Recombinant AAV Serotype 92018
- Author(s)
  Tomono Ｔ, Hirai Y, Okada H, Miyagawa Y, Adachi 1, Sakamoto S, Kawano Y, Chono H, Mineno J, Ishii A, Shimada T, Onodera M, Tamaoka A, Okada T.
- Journal Title
  
  Mol Ther Methods Clin Dev
  
  Volume: １１ Pages: 180-190
- DOI
  10.1016/j.omtm.2018.10.015
- NAID
  120007128300
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07081, KAKENHI-PROJECT-16K08644, KAKENHI-PROJECT-16K09964, KAKENHI-PROJECT-16K15093, KAKENHI-PROJECT-26293328
[Journal Article] AMPA Receptor Antagonist Perampanel Ameliorates Post-Stroke Functional and Cognitive Impairments2018
- Author(s)
  Nakajima Masataka、Suda Satoshi、Sowa Kota、Sakamoto Yuki、Nito Chikako、Nishiyama Yasuhiro、Aoki Junya、Ueda Masayuki、Yokobori Shoji、Yamada Marina、Yokota Hiroyuki、Okada Takashi、Kimura Kazumi
- Journal Title
  
  Neuroscience
  
  Volume: 386 Pages: 256-264
- DOI
  10.1016/j.neuroscience.2018.06.043
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26293328
[Journal Article] Impact of Dental Pulp Stem Cells Overexpressing Hepatocyte Growth Factor after Cerebral Ischemia/Reperfusion in Rats2018
- Author(s)
  Sowa K, Nito C, Nakajima M, Suda S, Nishiyama Y, Sakamoto Y, Nitahara-Kasahara Y, Nakamura-Takahashi A, Ueda M, Kimura K, Okada T
- Journal Title
  
  Mol Ther Methods Clin Dev
  
  Volume: 10 Pages: 281-290
- DOI
  10.1016/j.omtm.2018.07.009
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10742, KAKENHI-PROJECT-15K10317, KAKENHI-PROJECT-26293328
[Journal Article] Supplemental Treatment for Huntington’s Disease with miR-132 that Is Deficient in Huntington’s Disease Brain2018
- Author(s)
  Fukuoka Masashi、Takahashi Masaki、Fujita Hiromi、Chiyo Tomoko、Popiel H. Akiko、Watanabe Shoko、Furuya Hirokazu、Murata Miho、Wada Keiji、Okada Takashi、Nagai Yoshitaka、Hohjoh Hirohiko
- Journal Title
  
  Mol. Ther. Nucleic Acids
  
  Volume: 11 Pages: 79-90
- DOI
  10.1016/j.omtn.2018.01.007
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K19658, KAKENHI-PROJECT-16K19003, KAKENHI-PROJECT-16K15093, KAKENHI-PROJECT-17K20087, KAKENHI-PUBLICLY-17H05699, KAKENHI-PROJECT-16H05325
[Journal Article] MicroRNA cluster miR-17-92 regulates multiple functionally related voltage-gated potassium channels in chronic neuropathic pain2017
- Author(s)
  Sakai Atsushi、Saitow Fumihito、Maruyama Motoyo、Miyake Noriko、Miyake Koichi、Shimada Takashi、Okada Takashi、Suzuki Hidenori
- Journal Title
  
  Nature Communications
  
  Volume: 8 Issue: 1 Pages: 16079-16079
- DOI
  10.1038/ncomms16079
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09604, KAKENHI-PROJECT-16K10986, KAKENHI-PROJECT-16K15340, KAKENHI-PROJECT-17K16758, KAKENHI-PROJECT-26293328, KAKENHI-PROJECT-16H05461, KAKENHI-PROJECT-26461596
[Journal Article] Improved Intravitreal AAV-Mediated Inner Retinal Gene Transduction after Surgical Internal Limiting Membrane Peeling in Cynomolgus Monkeys.2017
- Author(s)
  Takahashi K, Igarashi T, Miyake K, Kobayashi M, Yaguchi C, Iijima O, Yamazaki Y, Katakai Y, Miyake N, Kameya S, Shimada T, Takahashi H, Okada T.
- Journal Title
  
  Mol Ther.
  
  Volume: 4；25 Issue: 1 Pages: 296-302
- DOI
  10.1016/j.ymthe.2016.10.008
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26293328, KAKENHI-PROJECT-15K09604, KAKENHI-PROJECT-26461596
[Journal Article] Mesenchymal Stem Cells Overexpressing Interleukin-10 Promote Neuroprotection in Experimental Acute Ischemic Stroke2017
- Author(s)
  Nakajima Masataka、Nito Chikako、Sowa Kota、Suda Satoshi、Nishiyama Yasuhiro、Nakamura-Takahashi Aki、Nitahara-Kasahara Yuko、Imagawa Kiwamu、Hirato Tohru、Ueda Masayuki、Kimura Kazumi、Okada Takashi
- Journal Title
  
  Mol Ther Methods Clin Dev.
  
  Volume: 6 Pages: 102-111
- DOI
  10.1016/j.omtm.2017.06.005
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26293328
[Journal Article] ゲノム情報と遺伝子治療 -遺伝子治療の最新動向- デュシェンヌ型筋ジストロフィー2017
- Author(s)
  岡田尚巳
- Journal Title
  
  日本臨床
  
  Volume: 75 Pages: 712-723
- Data Source
  KAKENHI-PROJECT-26293328
[Journal Article] DOK7　gene therapy enhances motor activity and life span in ALS model mice2017
- Author(s)
  Miyoshi Sadanori、Tezuka Tohru、Arimura Sumimasa、Tomono Taro、Okada Takashi、Yamanashi Yuji
- Journal Title
  
  EMBO Molecular Medicine
  
  Volume: 9 Issue: 7 Pages: 880-889
- DOI
  10.15252/emmm.201607298
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26293328, KAKENHI-PROJECT-16K14575
[Journal Article] Tyrosine triple mutated AAV2-BDNF gene therapy in a rat model of transient IOP elevation.2016
- Author(s)
  Igarashi T, Miyake K, Kobayashi M, Kameya S, Fujimoto C, Nakamoto K, Takahashi H, Igarashi T, Miyake N, Iijima O, Hirai Y, Shimada T, Okada T, Takahashi H
- Journal Title
  
  Mol Vis.
  
  Volume: 16 Pages: 816-826
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26293328
[Journal Article] Treatment of hypophosphatasia by muscle-directed expression of bone-targeted alkaline phosphatase via self-complementary AAV8 vector.2016
- Author(s)
  Nakamura-Takahashi,A., Miyake,K., Watanabe, A., Hirai, Y., Iijima, O., Miyake, N., Adachi K.,, Nitahara-Kasahara, Y., Kinoshita, H., Noguchi, T., Abe, S., Narisawa, S., Millán, J. L., Shimada, T.,Okada, T.
- Journal Title
  
  Molecular Therapy- Methods & Clinical Development
  
  Volume: 3 Pages: 15059-15059
- DOI
  10.1038/mtm.2015.59
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25460407, KAKENHI-PROJECT-25461564, KAKENHI-PROJECT-26293328
[Journal Article] IL-10 gene transfer upregulates arcuate POMC and ameliorates hyperphagia, obesity and diabetes by substituting for leptin.2016
- Author(s)
  Nakata M, Yamamoto S, Okada T, Gantulga D, Okano H, Ozawa K, Yada T.
- Journal Title
  
  Int J Obes (Lond).
  
  Volume: 40 Issue: 3 Pages: 425-433
- DOI
  10.1038/ijo.2015.201
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K09442, KAKENHI-PROJECT-24592277, KAKENHI-PROJECT-26293328
[Journal Article] Ultracentrifugation-free chromatography-mediated large-scale purification of recombinant adeno-associated virus serotype 1 (rAAV1).2016
- Author(s)
  Taro Tomono, Yukihiko Hirai, Hironori Okada, Kumi Adachi, Akiko Ishii, Takashi Shimada, Masafumi Onodera, Akira Tamaoka, and Takashi Okada
- Journal Title
  
  Molecular Therapy - Methods & Clinical Development
  
  Volume: 3 Pages: 15058-15058
- DOI
  10.1038/mtm.2015.58
- NAID
  120007128523
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26430102, KAKENHI-PROJECT-25460407, KAKENHI-PROJECT-26293328, KAKENHI-PROJECT-16K07081, KAKENHI-PROJECT-16K08644
[Journal Article] Paraventricular NUCB2/Nesfatin-1 Supports Oxytocin and Vasopressin Neurons to Control Feeding Behavior and Fluid Balance in Male Mice.2016
- Author(s)
  Nakata M, Gantulga D, Santoso P, Zhang B, Masuda C, Mori M, Okada T, Yada T
- Journal Title
  
  Endocrinology
  
  Volume: 157 Issue: 6 Pages: 2322-2332
- DOI
  10.1210/en.2015-2082
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26293328, KAKENHI-PROJECT-26670453
[Journal Article] Dystrophic mdx mice develop severe cardiac and respiratory dysfunction following genetic ablation of the anti-inflammatory cytokine IL-10.2015
- Author(s)
  Yuko Nitahara-Kasahara, Hiromi Hayashita-Kinoh, Tomoko Chiyo, Akiyo Nishiyama, Hironori Okada, Shin’ichi Takeda and Takashi Okada.
- Journal Title
  
  Hum Molecular Genetics
  
  Volume: 23（15） Issue: 15 Pages: 3990-4000
- DOI
  10.1093/hmg/ddu113
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24659265, KAKENHI-PROJECT-26430102, KAKENHI-PROJECT-26860273
[Journal Article] Fukutin is prerequisite to ameliorate muscular dystrophic phenotype by myofiber-selective LARGE expression.2015
- Author(s)
  Ohtsuka Y, Kanagawa M, Yu CC, Ito C, Chiyo T, Kobayashi K, Okada T, Takeda S’I, Toda T.
- Journal Title
  
  Sci Rep
  
  Volume: 5 Issue: 1 Pages: 8316-8316
- DOI
  10.1038/srep08316
- NAID
  120005600773
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-12F02422, KAKENHI-PLANNED-22129006, KAKENHI-PROJECT-24500472, KAKENHI-PROJECT-24687017, KAKENHI-PUBLICLY-26110712, KAKENHI-PROJECT-26253057, KAKENHI-PROJECT-26670499, KAKENHI-PROJECT-26293328
[Journal Article] Enzyme replacement in the CSF to treat metachromatic leukodystrophy in mouse model using single intracerebroventricular injection of self-complementary AAV1 vector.2015
- Author(s)
  Hironaka K, Yamazaki Y, Hirai Y, Yamamoto M, Miyake N, Miyake K, Okada T, Morita A, Shimada T.
- Journal Title
  
  Sci Rep.
  
  Volume: 18 Issue: 1 Pages: 1-12
- DOI
  10.1038/srep13104
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09604, KAKENHI-PROJECT-26461596, KAKENHI-PROJECT-25460407, KAKENHI-PROJECT-26293328
[Journal Article] LRP1 Downregulates the Alzheimer’s β-Secretase BACE1 by Modulating Its Intraneuronal Trafficking.2015
- Author(s)
  Daisuke Tanokashira, Kazumi Motoki, Seiji Minegishi,Ai Hosaka,Naomi Mamada,Akira Tamaoka,Takashi Okada,Madepalli K.Lakshmana,and Wataru Araki.
- Journal Title
  
  ENEURO
  
  Volume: 1 Pages: 6-15
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26293328
[Journal Article] Intra-Amniotic rAAV-Mediated Microdystrophin Gene Transfer Improves Canine X-Linked Muscular Dystrophy and May Induce Immune Tolerance.2015
- Author(s)
  Hiromi Hayashita-Kinoh, Naoko Yugeta, Hironori Okada, Yuko Nitahara-Kasahara, Tomoko Chiyo, Takashi Okada and Shin’ichi Takeda
- Journal Title
  
  Mol. Ther.
  
  Volume: 4 Issue: 4 Pages: 627-637
- DOI
  10.1038/mt.2015.5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24659265, KAKENHI-PROJECT-26430102, KAKENHI-PROJECT-26460502, KAKENHI-PROJECT-26860273, KAKENHI-PROJECT-26293328
[Journal Article] Paraventricular NUCB2/nesfatin-1 is directly targeted by leptin and mediates its anorexigenic effect2015
- Author(s)
  Darambazar G, Nakata M, Okada T, Wang L, Li E, Shinozaki A, Motoshima M, Mori M, Yada T.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 456（4） Issue: 4 Pages: 913-918
- DOI
  10.1016/j.bbrc.2014.12.065
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26293328, KAKENHI-PROJECT-26670453, KAKENHI-PROJECT-15K09442, KAKENHI-PROJECT-24592277
[Journal Article] Two distinct layer-specific dynamics of cortical ensembles during learning of a motor task.2014
- Author(s)
  Yoshito Masamizu, Yasuhiro R. Tanaka, Yasuyo H. Tanaka, Riichiro Hira, Kazuo Kitamura, Yoshikazu Isomura, Takashi Okada and Masanori Matsuzaki.
- Journal Title
  
  Nature Neurosci.
  
  Volume: 17(7) Pages: 987-994
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26293328
[Journal Article] Cell therapeutic approaches using multipotent mesenchymal stromal cells for muscular dystrophy2014
- Author(s)
  Yuko Nitahara-Kasahara, Shin’ichi Takeda and Takashi Okada.
- Journal Title
  
  Inflammation and Regeneration
  
  Volume: 34 Issue: 4 Pages: 198-205
- DOI
  10.2492/inflammregen.34.198
- NAID
  130004943866
- ISSN
  1880-8190, 1880-9693
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24659265
[Journal Article] DOK7 gene therapy benefits mouse models of diseases characterized by defects in the neuromuscular junction2014
- Author(s)
  Sumimasa Arimura, Takashi Okada, Tohru Tezuka, Tomoko Chiyo, Yuko Kasahara, Toshiro Yoshimura, Masakatsu Motomura, Nobuaki Yoshida, David Beeson, Shin’ichi Takeda, Yuji Yamanashi
- Journal Title
  
  Science
  
  Volume: 345 Issue: 6203 Pages: 1505-1508
- DOI
  10.1126/science.1250744
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23249013, KAKENHI-PROJECT-24500472, KAKENHI-PUBLICLY-25110711, KAKENHI-PROJECT-25460357, KAKENHI-PROJECT-25461318, KAKENHI-PROJECT-26293328, KAKENHI-PROJECT-26461302, KAKENHI-PROJECT-26860273
[Journal Article] Reward-timing-dependent bidirectional modulation of cortical microcircuits during optical single-neuron operant conditioning.2014
- Author(s)
  Hira R et al.
- Journal Title
  
  Nature Communications
  
  Volume: 5 Issue: 1 Pages: 5551-5551
- DOI
  10.1038/ncomms6551
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-22115005, KAKENHI-PROJECT-23300148, KAKENHI-PUBLICLY-25111703, KAKENHI-PUBLICLY-25116504, KAKENHI-PUBLICLY-26115504, KAKENHI-PROJECT-26282217, KAKENHI-PROJECT-26293328, KAKENHI-PROJECT-26560456, KAKENHI-PROJECT-26640002, KAKENHI-PROJECT-26830020, KAKENHI-PROJECT-26830021
[Journal Article] Current challenges and future directions in recombinant AAV-mediated gene therapy of Duchenne muscular dystrophy2013
- Author(s)
  Okada, T., Takeda, S
- Journal Title
  
  Pharmaceuticals
  
  Volume: 6 Issue: 7 Pages: 813-836
- DOI
  10.3390/ph6070813
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390284
[Journal Article] Robust long-term transduction of common marmoset neuromusculartissue with rAAV1 and rAAV9.2013
- Author(s)
  Hironori Okada, et al.
- Journal Title
  
  Molecular Therapy-Nucleic Acids
  
  Volume: 2 Pages: e95-e95
- DOI
  10.1038/mtna.2013.21
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J40134, KAKENHI-PROJECT-22390284, KAKENHI-PROJECT-23700521, KAKENHI-PUBLICLY-25118708
[Journal Article] Cell therapeutic approaches using multipotent mesencymal stromal cells for muscular dystrophy2013
- Author(s)
  Kasahara, Y., Takeda, S., Okada, T.
- Journal Title
  
  Inflammation and Regeneration
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659265
[Journal Article] Initial Pulmonary Respiration Causes Massive Diaphragm Damage and Hyper-CKemia in Duchenne Muscular Dystrophy Dog2013
- Author(s)
  Nakamura A, Kobayashi M, Kuraoka M, Yuasa K, Yugeta N, Okada T, Takeda S
- Journal Title
  
  Sci Rep
  
  Volume: 3 Issue: 1 Pages: 2183-2183
- DOI
  10.1038/srep02183
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24500472, KAKENHI-PROJECT-24659265
[Journal Article] Impaired viability of muscle precursor cells in muscular dystrophy with glycosylation defects and amelioration. of its severe phenotype by limited gene expression.2013
- Author(s)
  Kanagawa M, et. al.
- Journal Title
  
  Hum Mol Genet
  
  Volume: 22 Issue: 15 Pages: 3003-3015
- DOI
  10.1093/hmg/ddt157
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12F02422, KAKENHI-PLANNED-22129006, KAKENHI-PROJECT-23249049, KAKENHI-PROJECT-24590497, KAKENHI-PROJECT-24659265, KAKENHI-PROJECT-24687017, KAKENHI-PROJECT-25702044
[Journal Article] Robust long-term transduction of common marmoset neuromuscular tissue with rAAV1 and rAAV92013
- Author(s)
  Hironori Okada
- Journal Title
  
  Molecular Therapy - Nucleic Acids
  
  Volume: IN PRESS
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390284
[Journal Article] Local and retrograde gene transfer into primate neuronal pathways via adeno-associated virus serotype 8 and 92011
- Author(s)
  Masamizu Y., Okada T., Kawasaki K., Ishibashi H., Yuasa S. Takeda S., Hasegawa I. & Nakahara K
- Journal Title
  
  Neuroscience
  
  Volume: 193 Pages: 249-258
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500371
[Journal Article] Efficient gene transfer into neurons in monkey brain by adeno-associated virus 8.2010
- Author(s)
  正水芳人、岡田尚巳、石橋英俊、武田伸一、湯浅茂樹、中原潔
- Journal Title
  
  Neuroreport
  
  Volume: 21 Pages: 447-451
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500371
[Journal Article] Efficient gene transfer into neurons in monkey brain by adeno-associated virus 82010
- Author(s)
  Masamizu Y., Okada T., Ishibashi H.,Takeda S., Yuasa S. & Nakahara K
- Journal Title
  
  Neuroreport
  
  Volume: 21 Pages: 447-451
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500371
[Journal Article] Retroviral vector-producing mesenchymal stem cells for targeted suicide cancer gene therapy.2009
- Author(s)
  Uchibori, R., Okada, T., Ito, T., Urabe, M., Mizukami, H., Kume, A., Ozawa, K.
- Journal Title
  
  J. Gene Med. 11
  
  Pages: 373-381
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016067
[Journal Article] Scalable purification of AAV1 and AAV8 vectors using dual ion-exchange adsorptive membranes.2009
- Author(s)
  Okada T., Nonaka-Sarukawa M., Uchibori R., Kinoshita K., Hayashita-Kinoh H., Nitahara-Kasahara Y., Takeda S., Ozawa K.
- Journal Title
  
  Hum Gene Ther 20
  
  Pages: 1013-1021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390383
[Journal Article] Scalable purification of adeno-associated virus serotype 1 (AAV1) and AAV8 vectors, using dual ion-exchange adsorptive membranes.2009
- Author(s)
  Okada, T., Nonaka-Sarukawa, M., Uchibori, R., Kinoshita, K., Hayashita-Kinoh, H., Nitahara-Kasahara, Y., Takeda, S., Ozawa, K.
- Journal Title
  
  Hum. Gene Ther. 20(9)
  
  Pages: 1013-1021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016067
[Journal Article] Scalable purification of adeno-associated virus serotype 1 (AAV1) and AAV8 vectors, using dual ion-exchange adsorptive membranes.2009
- Author(s)
  Okada,T.
- Journal Title
  
  Hum.Gene Ther. 20
  
  Pages: 1013-1021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016067
[Journal Article] Scalable purification of AAV1 and AAV8 vectors using dual ion-exchange adsorptive membranes2009
- Author(s)
  Okada T, et al.
- Journal Title
  
  Hum Gene Ther 20
  
  Pages: 1013-1021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390383
[Journal Article] Systemic delivery of IL-10 by an AAV vector prevents vascular remodeling and end-organ damage in stroke-prone spontaneously hypertensive rat2009
- Author(s)
  Nomoto, T., Okada, T., Shimazaki, K., Yoshioka, T., Nonaka-Sarukawa, M., Ito, T., Takeuchi, K., Katsura, K. I., Mizukami, H., Kume, A., Ookawara, S., Ikeda, U., Katayama, Y., Ozawa, K.
- Journal Title
  
  Gene.Ther 16
  
  Pages: 383-91
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390383
[Journal Article] Systemic delivery of IL-10 by an AAV vector prevents vascular remodeling and end-organ damage in stroke-prone spontaneously hypertensive rat.2009
- Author(s)
  Nomoto T., Okada T., Shimazaki K., Yoshioka T., Nonaka-Sarukawa M., Ito T., Takeuchi K., Katsura K.I., Mizukami H., Kume A., Ookawara S., Ikeda U., Katayama Y., Ozawa K.
- Journal Title
  
  Gene Ther 16
  
  Pages: 383-91
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390383
[Journal Article] Scalable purification of AAV1 and AAV8 vectors using dual ion-exchange adsorptive membranes2009
- Author(s)
  Okada, T., Nonaka-Sarukawa, M., Uchibori, R., Kinoshita, K., Hayashita-Kinoh, H., Nitahara-Kasahara, Y., Takeda, S., Ozawa, K.
- Journal Title
  
  Hum Gene Ther 20
  
  Pages: 1013-1021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390383
[Journal Article]2008
- Author(s)
  Okada, T., et al.
- Journal Title
  
  Vector-producing mesenchymal stem cells for cancer gene therapy. In : Gene Therapy and Cancer Research Focus(Nova Science Publishers, Inc.)
  
  Pages: 9-17
- Data Source
  KAKENHI-PROJECT-19659144
[Journal Article] Protection against aminoglycoside-induced ototoxicity by regulated AAV vector-mediated GDNF gene transfer into the cochlea.2008
- Author(s)
  Liu, Y., Okada, T., Shimazaki, K., Sheykholeslami, K., Nomoto, T., Muramatsu, S., Mizukami, H., Kume, A., Xiao, S., Ichimura, K., Ozawa, K.
- Journal Title
  
  Mol. Ther. 16(3)
  
  Pages: 474-480
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016067
[Journal Article]2008
- Author(s)
  岡田尚巳, 他
- Journal Title
  
  癌幹細胞の同定法、がん転移研究の実験手法(金芳堂)
  
  Pages: 311-317
- Data Source
  KAKENHI-PROJECT-19659144
[Journal Article] 間葉系幹細胞を利用した癌遺伝子治療2008
- Author(s)
  岡田尚巳
- Journal Title
  
  最新医学 63
  
  Pages: 64-71
- Data Source
  KAKENHI-PROJECT-19659144
[Journal Article] Adeno-associated virus vector-mediated systemic interleukin-10 expression ameliorates hypertensive organ damage in Dahl salt-sensitive rats.2008
- Author(s)
  Nonaka-Sarukawa, M., Okada, T., Ito, T., Yamamoto, K., Yoshioka, T., Nomoto, T., Hojo, Y., Shimpo, M., Urabe, M., Mizukami, H., Kume, A., Ikeda, U., Shimada, K., Ozawa, K.
- Journal Title
  
  J Gene Med. 10(4)
  
  Pages: 368-374
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016067
[Journal Article] Vector-producing tumor-tracking multipotent mesenchymal stromal cells for suicide cancer gene therapy2008
- Author(s)
  Okada, T., et al.
- Journal Title
  
  Front Biosci 13
  
  Pages: 1887-1891
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19659144
[Journal Article] 遺云子導入「筋ジストロフィー -現在と未来」2008
- Author(s)
  岡田尚巳, 他
- Journal Title
  
  Clinical Neuroscience 26
  
  Pages: 204-206
- Data Source
  KAKENHI-PROJECT-19390383
[Journal Article] Prevention of diabetic retinopathy by intraocular soluble Flt-1 gene transfer in a spontaneously diabetic rat model.2007
- Author(s)
  Ideno, J., Mizukami, H., Kakehashi, A., Saito, Y., Okada, T., Urabe, M., Kume, A., Kuroki, M., Kawakami, M., Ishibashi, S., Ozawa, K.
- Journal Title
  
  Int. J. Mol. Med. 19
  
  Pages: 75-79
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016067
[Journal Article] Interleukin-10 Expression Mediated by an Adeno-Associated Virus Vector Prevents Monocrotaline-Induced Pulmonary Arterial Hypertension in Rats2007
- Author(s)
  Ito, T., Okada, T., Miyashita, H., Nomoto, T., Nonaka-Sarukawa, M., Uchibori, R., Maeda, Y., Urabe, M., Mizukami, H., Kume, A., Takahashi, M., Ikeda, U., Shimada, K., Ozawa, K.
- Journal Title
  
  Circ Res 101
  
  Pages: 734-741
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390383
[Journal Article] Adeno-associated virus-mediated prostacyclin synthase expression prevents pulmonary arterial hypertension in rats.2007
- Author(s)
  Ito, T., Okada, T., Mimuro, J., Miyashita, H., Uchibori, R., Urabe, M., Mizukami, H., Kume, A., Takahashi, M., Ikeda, U., Sakata, Y., Shimada, K., Ozawa, K.
- Journal Title
  
  Hypertension 50
  
  Pages: 531-536
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016067
[Journal Article] Interleukin-10 Expression Mediated by an Adeno-Associated Virus Vector Prevents Monocrotaline-Induced Pulmonary Arterial Hypertension in Rats.2007
- Author(s)
  Ito T., Okada T., Miyashita H., Nomoto T., Nonaka-Sarukawa M., Uchibori R., Maeda Y., Urabe M., Mizukami H., Kume A., Takahashi M., Ikeda U., Shimada K., Ozawa K.
- Journal Title
  
  Circ Res 101
  
  Pages: 734-741
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390383
[Journal Article] Interleukin-10 expression mediated by an adeno-associated virus vector prevents monocrotaline-induced pulmonary arterial hypertension in rats.2007
- Author(s)
  Ito, T., Okada, T., Miyashita, H., Nomoto, T., Nonaka-Sarukawa, M., Uchibori, R., Maeda, Y., Urabe, M., Mizukami, H., Kume, A., Takahashi, M., Ikeda, U., Shimada, K., Ozawa, K.
- Journal Title
  
  Circ. Res. 101
  
  Pages: 734-741
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016067
[Journal Article] 遺伝子導入「筋ジストロフィー-現在と未来」2007
- Author(s)
  岡田尚巳, 他
- Journal Title
  
  Clinical Neuroscience 26
  
  Pages: 204-206
- Data Source
  KAKENHI-PROJECT-19390383
[Journal Article] Utility of intraperitoneal administration as a route of AAV serotype 5 vector-mediated neonatal gene transfer.2006
- Author(s)
  Ogura, T., Mizukami, H., Mimuro, J., Madoiwa, S., Okada, T., Matsushita, T., Urabe, M., Kume, A., Hamada, H., Yoshikawa, H., Sakata, Y., Ozawa, K.
- Journal Title
  
  Gene Med. 8
  
  Pages: 990-997
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016067
[Journal Article] A histone deacetylase inhibitor enhances recombinant adeno-associated virus-mediated gene expression in tumor cells.2006
- Author(s)
  Okada, T., Uchibori, R., Iwata-Okada, M., Takahashi, M., Nomoto, T., Nonaka-Sarukawa, M., Ito, T., Liu, Y., Mizukami, H., Kume, A., Kobayashi, E., Ozawa, K.
- Journal Title
  
  Mol. Ther. 13
  
  Pages: 738-746
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016067
[Journal Article] Suppression of ovarian cancer by muscle-mediated expression of soluble VEGFR-1/Flt-1 using adeno-associated virus serotype 1-derived vector.2006
- Author(s)
  Takei, Y., Mizukami, H., Saga, Y., Yoshimura, I., Hasumi, Y., Takayama, T., Kohno, T., Matsushita, T., Okada, T., Kume, A., Suzuki, M., Ozawa, K.
- Journal Title
  
  Int. J. Cancer 120
  
  Pages: 278-284
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016067
[Journal Article] A histone deacetylase inhibitor enhances recombinant adeno-associated virus-mediated gene expression in tumor cells2006
- Author(s)
  Okada, T. et al.
- Journal Title
  
  Mol Ther 13・4
  
  Pages: 738-746
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390418
[Journal Article] A histone deacetylase inhibitor enhances recombinant adeno-associated virus-mediated gene expression in tumor cells.2006
- Author(s)
  Okada, T
- Journal Title
  
  Mot.Ther. 13・44
  
  Pages: 738-746
- Data Source
  KAKENHI-PROJECT-17016067
[Journal Article] IL-10発現AAVベクターを用いた心血管病変の遺伝子治療2006
- Author(s)
  岡田尚巳 et al.
- Journal Title
  
  最新医学. 61・4
  
  Pages: 113-121
- Data Source
  KAKENHI-PROJECT-16390418
[Journal Article] Viral-mediated temporally controlled dopamine production in a rat model of Parkinson disease.2006
- Author(s)
  Li, X.G., Okada, T., Kodera, M., Nara, Y., Takino, N., Muramatsu, C., Ikeguchi, K., Urano, F., Ichinose, H., Metzger, D., Chambon, P., Nakano, I., Ozawa, K., Muramatsu, S.
- Journal Title
  
  Mol. Ther. 13
  
  Pages: 160-166
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016067
[Journal Article] rAAV-mediated shRNA ameliorated 6 neuropathology in Huntington disease model mouse. Biochem.2006
- Author(s)
  Machida, Y., Okada, T., Kurosawa, M., Oyama, F., Ozawa, K., Nukina, N.
- Journal Title
  
  Biophys. Res. Commun. 343
  
  Pages: 190-197
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016067
[Journal Article] Adipose tissue as a novel target for in vivo gene transfer by adeno-associated viral vectors.2006
- Author(s)
  Mizukami, H., Mimuro, J., Ogura, T., Okada, T., Urabe, M., Kume, A., Sakata, Y., Ozawa, K.
- Journal Title
  
  Hum. Gene Ther. 17
  
  Pages: 921-928
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016067
[Journal Article] Phenotype correction of hemophilia A mice with adeno-associated virus vectors carrying the B domain-deleted canine factor VIII gene.2006
- Author(s)
  Ishiwata, A., Mimuro, J., Kashiwakura, Y., Niimura, M., Takano, K., Ohmori, T., Madoiwa, S., Mizukami, H., Okada, T., Naka, H., Yoshioka, A., Ozawa, K., Sakata, Y.
- Journal Title
  
  Thromb. Res. 118
  
  Pages: 627-635
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016067
[Journal Article] Efficient and stable Sendai virus-mediated gene transfer into primate embryonic stem cells with pluripotency preserved.2005
- Author(s)
  Sasaki, K., Inoue, M., Shibata, H., Ueda, Y., Muramatsu, S., Okada, T., Hasegawa, M., Ozawa, K., Hanazono, Y.
- Journal Title
  
  Gene Ther. 12
  
  Pages: 203-210
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016067
[Journal Article] Large-scale production of recombinant viruses using a large culture vessel with active gassing.2005
- Author(s)
  Okada, T. et al.
- Journal Title
  
  Hum. Gene Ther. 16・10
  
  Pages: 1212-1218
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390418
[Journal Article] Large-scale production of recombinant viruses by use of a large culture vessel with active gassing.2005
- Author(s)
  Okada, T., Nomoto, T., Yoshioka, T., Nonaka-Sarukawa, M., Ito, T., Ogura, T., Iwata-Okada, M., Uchibori, R., Shimazaki, K., Mizukami, H., Kume, A., Ozawa, K.
- Journal Title
  
  Hum. Gene Ther. 16
  
  Pages: 1212-1218
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016067
[Journal Article] Specific and efficient transduction of cochlear inner hair cells with recombinant adeno-associated virus type 3 vector.2005
- Author(s)
  Liu, Y., Okada, T., Sheykholeslami, K., Shimazaki, K., Nomoto, T., Muramatsu, S., Kanazawa, T., Takeuchi, K., Ajalli, R., Mizukami, H., Kume, A., Ichimura, K., Ozawa, K.
- Journal Title
  
  Mol. Ther. 12
  
  Pages: 725-733
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016067
[Journal Article] Large-scale production of recombinant viruses by use of a large culture vessel with active gassing.2005
- Author(s)
  Okada, T.
- Journal Title
  
  Hum.Gene Ther. 16・10
  
  Pages: 1212-1218
- Data Source
  KAKENHI-PROJECT-17016067
[Journal Article] Large-scale production of recombinant viruses using a large culture vessel with active gassing.2005
- Author(s)
  Okada, T.et al.
- Journal Title
  
  Hum.Gene Ther. 16・10
  
  Pages: 1212-1218
- Data Source
  KAKENHI-PROJECT-16390418
[Journal Article] In situ generation of pseudotyped retroviral progeny by adenovirus-mediated transduction of tumor cells enhances the killing effect of HSV-tk suicide gene therapy in vitro and in vivo.2004
- Author(s)
  Okada T., et al.
- Journal Title
  
  J.Gene Med. 6・3
  
  Pages: 288-299
- Data Source
  KAKENHI-PROJECT-13218116
[Journal Article] A histone deacetylase inhibitor enhances recombinant adeno-associated virus-mediated gene expression in tumor cells.
- Author(s)
  Okada, T.
- Journal Title
  
  Mol.Ther. (in press)
- Data Source
  KAKENHI-PROJECT-17016067
[Journal Article] A histone deacetylase inhibitor enhances recombinant adeno-associated virus-mediated gene expression in tumor cells.
- Author(s)
  Okada, T.et al.
- Journal Title
  
  Mol.Ther. (in press)
- Data Source
  KAKENHI-PROJECT-16390418
[Journal Article] 遺伝子発現制御法とその応用
- Author(s)
  岡田尚巳 et al.
- Journal Title
  
  分子細胞治療 5・3(in press)
- Data Source
  KAKENHI-PROJECT-16390418
[Patent] スタッファーＤＮＡを含む組換えプラスミド2024
- Inventor(s)
  岡田尚巳、和田美加子、蝶野英人、月原多佳久、岡本功
- Industrial Property Rights Holder
  岡田尚巳、和田美加子、蝶野英人、月原多佳久、岡本功
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2024-049856
- Filing Date
  2024
- Data Source
  KAKENHI-PROJECT-23K20328
[Patent] ナノポアデバイスを用いたウイルス由来のカプシドに含まれる核酸のサイズに関連する情報の取得方法、当該取得方法に用いられるナノポアデバイスおよび取得装置2023
- Inventor(s)
  岡田尚巳、恒川雄二、筒井真楠、川合知二、馬場嘉信、他2名
- Industrial Property Rights Holder
  岡田尚巳、恒川雄二、筒井真楠、川合知二、馬場嘉信、他2名
- Industrial Property Rights Type
  特許
- Filing Date
  2023
- Data Source
  KAKENHI-PROJECT-23K20328
[Patent] ウイルス粒子検出方法、情報処理装置及びウイルス粒子検出プログラム2023
- Inventor(s)
  岡田尚巳、松坂恭成、和田美加子
- Industrial Property Rights Holder
  岡田尚巳、松坂恭成、和田美加子
- Industrial Property Rights Type
  特許
- Filing Date
  2023
- Data Source
  KAKENHI-PROJECT-23K20328
[Patent] 改良型アデノ随伴ウイルスベクター2020
- Inventor(s)
  岡田尚巳、五十嵐勉、塩澤朝香
- Industrial Property Rights Holder
  岡田尚巳、五十嵐勉、塩澤朝香
- Industrial Property Rights Type
  特許
- Filing Date
  2020
- Acquisition Date
  2023
- Overseas
- Data Source
  KAKENHI-PROJECT-23K20328
[Patent] 核酸封入AAV中空粒子2020
- Inventor(s)
  岡田尚巳、岡田浩典、宮川世志幸、峰野純一、蝶野英人
- Industrial Property Rights Holder
  岡田尚巳、岡田浩典、宮川世志幸、峰野純一、蝶野英人
- Industrial Property Rights Type
  特許
- Filing Date
  2020
- Acquisition Date
  2024
- Data Source
  KAKENHI-PROJECT-23K20328
[Patent] 改良型アデノ随伴ウイルスベクター2019
- Inventor(s)
  岡田尚巳、李朝香、五十嵐勉
- Industrial Property Rights Holder
  岡田尚巳、李朝香、五十嵐勉
- Industrial Property Rights Type
  特許
- Filing Date
  2019
- Overseas
- Data Source
  KAKENHI-PROJECT-26293328
[Patent] 筋萎縮性側索硬化症を含む神経疾患の予防剤及び/又は治療剤2018
- Inventor(s)
  望月秀樹、長野清一、佐々木勉、鐘其静、岡田尚巳、平井幸彦
- Industrial Property Rights Holder
  望月秀樹、長野清一、佐々木勉、鐘其静、岡田尚巳、平井幸彦
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2018-141692
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-26293328
[Patent] Pelizaeus-Merzbacher病（PMD）治療薬2018
- Inventor(s)
  井上健、Li Heng、岡田尚巳
- Industrial Property Rights Holder
  国立精神・神経医療研究センター、学校法人日本医科大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2018-019950
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-26293328
[Patent] 薬剤取り込み増強剤2013
- Inventor(s)
  岡田尚巳、千代智子、武田伸一
- Industrial Property Rights Holder
  国立精神･神経医療研究センター
- Industrial Property Rights Type
  特許
- Filing Date
  2013-03-29
- Data Source
  KAKENHI-PROJECT-22390284
[Patent] 移植用幹細胞及びその製造方法2013
- Inventor(s)
  岡田尚巳、笠原優子、武田伸一
- Industrial Property Rights Holder
  国立精神･神経医療研究センター
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2013-108408
- Filing Date
  2013-05-22
- Data Source
  KAKENHI-PROJECT-24659265
[Patent] 薬剤送達粒子及びその製造方法2012
- Inventor(s)
  岡田尚巳，武田伸一，喜納裕美
- Industrial Property Rights Holder
  国立精神･神経医療研究センター
- Industrial Property Rights Type
  特許
- Filing Date
  2012-04-16
- Data Source
  KAKENHI-PROJECT-22390284
[Patent] 薬剤取り込み増強剤2012
- Inventor(s)
  岡田尚巳, 千代智子, 武田伸一
- Industrial Property Rights Holder
  NCNP
- Industrial Property Number
  2012-078035
- Filing Date
  2012-03-29
- Data Source
  KAKENHI-PROJECT-22390284
[Patent] 薬剤送達粒子及びその製造方法2011
- Inventor(s)
  岡田尚巳, 武田伸一, 喜納裕美
- Industrial Property Rights Holder
  NCNP
- Industrial Property Number
  2011-092252
- Filing Date
  2011-04-18
- Data Source
  KAKENHI-PROJECT-22390284
[Patent] 遺伝子導入効率増強剤および商業的パッケージ2010
- Inventor(s)
  岡田尚巳、小澤敬也
- Industrial Property Rights Holder
  岡田尚巳、株)ジェネシスヘルスケア
- Acquisition Date
  2010-09-17
- Data Source
  KAKENHI-PROJECT-19390383
[Patent] 組換えアデノウイルス迅速構築システム2010
- Inventor(s)
  岡田尚巳
- Industrial Property Rights Holder
  ヒューマンサイエンス振興財団
- Industrial Property Number
  2008-330838
- Filing Date
  2010-12-25
- Data Source
  KAKENHI-PROJECT-19390383
[Patent] 組換えアデノウイルス迅速構築システム2008
- Inventor(s)
  岡田尚巳
- Industrial Property Rights Holder
  HS振興財団
- Industrial Property Number
  2008-330838
- Filing Date
  2008-12-25
- Data Source
  KAKENHI-PROJECT-19659144
[Patent] 組換えアデノウイルス迅速構築システム2008
- Inventor(s)
  岡田尚巳
- Industrial Property Rights Holder
  ヒューマンサイエンス振興財団
- Industrial Property Number
  2008-330838
- Filing Date
  2008-12-25
- Data Source
  KAKENHI-PROJECT-19390383
[Patent] ベクター産生型腫瘍標的細胞2007
- Inventor(s)
  岡田尚巳, 小澤敬也
- Industrial Property Rights Holder
  自治医大
- Industrial Property Number
  2006-116504
- Filing Date
  2007-01-05
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390418
[Patent] 遺伝子導入効率増強剤2005
- Inventor(s)
  岡田尚巳, 小澤敬也
- Industrial Property Rights Holder
  日本ウェイトマネージメント, 岡田尚巳
- Filing Date
  2005-10-24
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390418
[Patent] 遺伝子導入効率増強剤2005
- Inventor(s)
  岡田尚巳, 小澤敬也
- Industrial Property Rights Holder
  日本ウェイトマネージメント, 岡田尚巳
- Filing Date
  2005-10-24
- Data Source
  KAKENHI-PROJECT-16390418
[Patent] ウイルス中空粒子の迅速除去および精製方法2005
- Inventor(s)
  岡田尚巳, 小澤敬也
- Industrial Property Rights Holder
  Pall Life Science
- Industrial Property Number
  2005-314476
- Filing Date
  2005-10-28
- Data Source
  KAKENHI-PROJECT-16390418
[Patent] ウイルス中空粒子の迅速除去および精製方法2005
- Inventor(s)
  岡田尚巳, 小澤敬也
- Industrial Property Rights Holder
  Pall Life Science
- Industrial Property Number
  2005-314476
- Filing Date
  2005-10-28
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390418
[Patent] 遺伝子導入効率増強剤2003
- Inventor(s)
  岡田尚巳, 小澤敬也
- Industrial Property Rights Holder
  藤沢薬品
- Industrial Property Number
  2003-122968
- Filing Date
  2003-04-25
- Data Source
  KAKENHI-PROJECT-13218116
[Patent] アデノウイルス吸着架橋剤2002
- Inventor(s)
  伊藤章, 花園裕, 岡田尚巳, 小沢敬也
- Industrial Property Rights Holder
  旭化成
- Industrial Property Number
  2002-299062
- Filing Date
  2002-10-11
- Acquisition Date
  2003-07-09
- Data Source
  KAKENHI-PROJECT-13218116
[Patent] Gene Introduction Efficiency Enhancer
- Inventor(s)
  岡田尚巳、小澤敬也
- Industrial Property Rights Holder
  岡田尚巳、株)ジェネシスヘルスケア
- Overseas
- Data Source
  KAKENHI-PROJECT-19390383
[Presentation] Large-scale production of high-quality recombinant adeno-associated virus using short-term zonal ultracentrifugation.2023
- Author(s)
  Wada M, Uchida N, Posadas-Herrera G, Hayashita-Kinoh H, Tsunekawa Y, Hirai Y, Okada T.
- Organizer
  American Society of Gene & Cell Therapy 26th Annual Meeting.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K20328
[Presentation] Duchenne型筋ジストロフィーモデル動物を用いた羊膜間葉系細胞の治療効果2023
- Author(s)
  笠原優子, 倉岡睦季, 木村公一, 峰岸かつら, 中山宗哉, 林真広, 中石智之, 上田恭義, 青木吉嗣, 岡田尚巳
- Organizer
  第9回日本筋学会学術集会・第10回筋ジストロフィー医療研究会合同学術集会
- Data Source
  KAKENHI-PROJECT-23K20328
[Presentation] 高耐久性アデノ随伴ウイルス受容体の開発とAAVベクター分析への応用2023
- Author(s)
  吉田浩平, 恒川雄二, 栗原健人, 渡邉和哉, 牧野友理子, 大村慧太, 田中亨, 井出輝彦, 岡田尚巳
- Organizer
  第29回日本遺伝子細胞治療学会学術集会
- Data Source
  KAKENHI-PROJECT-23K20328
[Presentation] 細胞外小胞を用いたAAVベクターによる新規ワクチンモダリティ開発2023
- Author(s)
  松坂恭成, 菅生健, 古寺紘人, 恒川雄二, 喜納裕美, 奈古屋美穂, 和田美加子, 笠原優子, 平井幸彦, 岡田尚巳
- Organizer
  第29回日本遺伝子細胞治療学会学術集会
- Data Source
  KAKENHI-PROJECT-23K20328
[Presentation] 羊膜間葉系間質細胞を用いた筋ジストロフィーモデル動物における治療評価2023
- Author(s)
  笠原優子、倉岡睦季、木村公一、峰岸かつら、林真広、中石智之、上田　恭義、青木吉嗣、岡田尚巳
- Organizer
  第23回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-23K20328
[Presentation] 筋ジストロフィーに対する遺伝子細胞治療2023
- Author(s)
  岡田尚巳
- Organizer
  日本筋学会シンポジウム2（教育シンポジウム）第9回日本筋学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-23K20328
[Presentation] デュシェンヌ型筋ジストロフィーに対する羊膜由来間葉系細胞の新たな治療標的2023
- Author(s)
  笠原優子, 中山宗哉, 木村公一, 山口翔, 垣内祐子, 仁藤智香子, 林真広, 中石智之, 上田恭義, 岡田尚巳
- Organizer
  第29回日本遺伝子細胞治療学会学術集会
- Data Source
  KAKENHI-PROJECT-23K20328
[Presentation] 大規模製造に向けたゾーナル超遠心による短時間高精度組換えアデノ随伴ウイルスベクター精製法の開発2023
- Author(s)
  和田美加子,恒川雄二,菅生健,平井幸彦,ポサダス・エレラ・ギジェルモ,喜納（早下）裕美,岡田尚巳
- Organizer
  第29回日本遺伝子細胞治療学会学術集会
- Data Source
  KAKENHI-PROJECT-23K20328
[Presentation] Production of high-quality recombinant adeno-associated virus using short-term and large-scale zonal ultracentrifugation.2023
- Author(s)
  Wada M, Hirai Y, Sugo K, Tsunekawa Y, Posadas-Herrera G, Hayashita-Kinoh H, Nagoya M, Nishina M, Okada T.
- Organizer
  1st AMED-SCARDA Joint Symposium of Japan Initiative for World-leading Vaccine Research and Development Centers
- Data Source
  KAKENHI-PROJECT-23K20328
[Presentation] アデノ随伴ウイルス（AAV）ベクター粒子の自動判別システムの開発2023
- Author(s)
  松坂恭成、和田美加子、岡田尚巳
- Organizer
  東京大学生命科学シンポジウム若手ワークショップ
- Data Source
  KAKENHI-PROJECT-23K20328
[Presentation] "Targeted Gene Delivery to the Brain with Smartly-Polymer Coated Adeno- associated Virus 9 (AAV9) Assisted by High Intensity Focused Ultrasound Enhances Safety and Efficacy2023
- Author(s)
  Hiroaki Kinoh, Shuhei Nagao, Yuto Honda, Takahiro Nomoto, Nozomi Matsudaira, Hiromi Hayashita-Kinoh, Tadashi Okada, Kazunori Kataoka, Nobuhiro Nishiyama
- Organizer
  第29回日本遺伝子細胞治療学会学術集会
- Data Source
  KAKENHI-PROJECT-23K20328
[Presentation] AAVベクターを用いた筋ジストロフィーに対する遺伝子細胞治療2023
- Author(s)
  岡田尚巳
- Organizer
  国立大学法人金沢大学第5回学術交流会
- Invited
- Data Source
  KAKENHI-PROJECT-23K20328
[Presentation] タンジェンシャルフローろ過を用いたAAVベクターの新規精製法の開発2023
- Author(s)
  宮岡理美, 恒川雄二, 黒沢八重, 佐々木貴子, 垣内裕子, 和田美加子, 笠原優子, 喜納裕美, 岡田尚巳
- Organizer
  第29回日本遺伝子細胞治療学会学術集会
- Data Source
  KAKENHI-PROJECT-23K20328
[Presentation] 筋ジストロフィー治療の最前線2023
- Author(s)
  木村公一、森田啓行、中西弘毅、中村昭則、松村剛、伊藤英樹、松尾雅文、岡田尚巳
- Organizer
  第41回日本神経治療学会学術集会
- Data Source
  KAKENHI-PROJECT-23K20328
[Presentation] 遺伝子・細胞治療におけるウイルスベクターの製造技術/品質管理と安全性・品質評価2022
- Author(s)
  岡田尚巳
- Organizer
  サイエンス&テクノロジーセミナー
- Data Source
  KAKENHI-PROJECT-23K20328
[Presentation] 遺伝子細胞治療を支えるウイルス・ベクター製造の課題克服に向けた取り組み2022
- Author(s)
  岡田尚巳
- Organizer
  ARO協議会　第9回学術集会専門家連絡会企画シンポジウム 1
- Data Source
  KAKENHI-PROJECT-23K20328
[Presentation] Development of Administration Protocols for Reduction of the Necessary Dose of rAAV for Treatment2022
- Author(s)
  Hayashita-Kinoh H, Posadas-Herrera G, Nitahara- Kasahara Y, Kuraoka M, Takeda S, Okada T.
- Organizer
  ASGCT 25th Annual Meeting
- Data Source
  KAKENHI-PROJECT-23K20328
[Presentation] High-quality purification at a large scale for recombinant adeno-associated virus using short-term zonal ultracentrifugation2022
- Author(s)
  Wada M, Uchida N, Posadas-Herrera G, Hayashita-Kinoh H, Tsunekawa Y, Hirai Y, Okada T.
- Organizer
  ASGCT 25th Annual Meeting
- Data Source
  KAKENHI-PROJECT-23K20328
[Presentation] AAVベクターを用いた遺伝子治療と課題2022
- Author(s)
  岡田尚巳
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-23K20328
[Presentation] Development of dosing protocol to reduce the required dose of rAAV using adult stem cells.2022
- Author(s)
  Hayashita-Kinoh H, Posadas-Herrera G, Nitahara-Kasahara Y, Ishii A, Takeda S, Okada T.
- Organizer
  The 28th Annual Meeting of Japan Society of Gene and Cell Therapy Symposium
- Data Source
  KAKENHI-PROJECT-23K20328
[Presentation] AAVベクター大量製造と品質評価2022
- Author(s)
  岡田尚巳
- Organizer
  第8回ファーマラボEXPO大阪
- Data Source
  KAKENHI-PROJECT-23K20328
[Presentation] AAVベクターを用いた遺伝子治療の現状と課題2022
- Author(s)
  岡田尚巳
- Organizer
  日経バイオテクセミナー
- Data Source
  KAKENHI-PROJECT-23K20328
[Presentation] Anti-inflammatory properties of IL-10-expressing multipotent mesenchymal stromal cells for Duchenne muscular dystrophy.2022
- Author(s)
  Nitahara-Kasahara Y, Kuraoka M, Hayashita-Kinoh H, Takeda S, Okada T.
- Organizer
  ASGCT 25th Annual Meeting
- Data Source
  KAKENHI-PROJECT-23K20328
[Presentation] 羊膜間葉系幹細胞を用いた筋ジストロフィーに対する細胞治療2022
- Author(s)
  笠原優子、中山宗哉、木村公一、山口翔、垣内祐子、仁藤智香子、林真広、中石智之、上田恭義、岡田尚巳
- Organizer
  第8回日本筋学会学術集会
- Data Source
  KAKENHI-PROJECT-23K20328
[Presentation] 高品質遺伝子治療ベクター製造法の確立に向けた戦略的技術基盤2022
- Author(s)
  岡田尚巳
- Organizer
  再生医療産業化フォーラム
- Data Source
  KAKENHI-PROJECT-23K20328
[Presentation] アデノ随伴ウイルス（AAV）ベクター粒子の自動判別システムの開発2022
- Author(s)
  松坂恭成、和田美加子、岡田尚巳
- Organizer
  第28回日本遺伝子細胞治療学会学術集会
- Data Source
  KAKENHI-PROJECT-23K20328
[Presentation] 核酸医療から遺伝子細胞治療へ2022
- Author(s)
  岡田尚巳
- Organizer
  第3回武蔵野フォーラム
- Data Source
  KAKENHI-PROJECT-23K20328
[Presentation] AAVベクターを用いた遺伝子治療と課題2022
- Author(s)
  岡田尚巳
- Organizer
  第7回日本核酸医薬学会
- Data Source
  KAKENHI-PROJECT-23K20328
[Presentation] ウイルスベクター技術を駆使した遺伝子治療の最新トレンド2021
- Author(s)
  岡田尚巳
- Organizer
  第34回AMTEF(Asahi Kasei Medical Marketing and Technology Forum)特別講演
- Data Source
  KAKENHI-PROJECT-23K20328
[Presentation] デュシェンヌ型筋ジストロフィーの分子病態と遺伝子細胞治療2021
- Author(s)
  岡田尚巳
- Organizer
  名城大学難治性疾患発症メカニズム研究センター特別講演
- Invited
- Data Source
  KAKENHI-PROJECT-23K20328
[Presentation] AAVの組織指向性変更-遺伝子治療用製品の生体内分布をデザインする-2021
- Author(s)
  岡田尚巳
- Organizer
  第6回DIA再生医療製品・遺伝子治療用製品シンポジウム
- Data Source
  KAKENHI-PROJECT-23K20328
[Presentation] バイオ医薬品の製造や品質管理、遺伝子治療薬2021
- Author(s)
  岡田尚巳
- Organizer
  新化学技術推進協会
- Invited
- Data Source
  KAKENHI-PROJECT-23K20328
[Presentation] 最適化エレクトロポレーションプロトコルにより作製されたウイルスベクター産生羊膜間葉系幹細胞(VP-AMSCs)の機能的評価2021
- Author(s)
  山崎吉之、笠原優子、宮崎海、宮川世志幸、岡田尚巳
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-23K20328
[Presentation] 遺伝子細胞治療ベクター技術の進化と今後の可能性2021
- Author(s)
  岡田尚巳
- Organizer
  BioJapan主催者セミナー
- Data Source
  KAKENHI-PROJECT-23K20328
[Presentation] AAVベクター大量製造と品質評価2021
- Author(s)
  岡田尚巳
- Organizer
  第23回インターフェックスジャパン
- Data Source
  KAKENHI-PROJECT-23K20328
[Presentation] バイオ医薬品と遺伝子治療ウイルスベクターの分析・品質管理と規制科学遺伝子治療の開発動向と課題2021
- Author(s)
  岡田尚巳
- Organizer
  蛋白質科学会ワークショップ
- Data Source
  KAKENHI-PROJECT-23K20328
[Presentation] CRISPR/Cas9を用いて作成した筋拘縮型エーラス・ダンロス症候群モデルマウスの表現型2020
- Author(s)
  笠原優子、積田奈々、水本秀二、井上（上野）由紀子、井上高良、髙橋（中村）有希、吉沢隆浩、髙橋有希、宮田真路、山田修平、武田伸一、渡邉淳、野村義宏、古庄知己、岡田尚巳
- Organizer
  第1回日本エーラス・ダンロス研究
- Data Source
  KAKENHI-PROJECT-19H03616
[Presentation] Optimization of protocol to generate a retroviral vector-producing amniotic mesenchymal stem cells (VP-AMSCs) for cancer cell therapy.2020
- Author(s)
  Yamazaki Y, Nitahara-Kasahara Y, Miyazaki K, Miyagawa Y, Okada T.
- Organizer
  The 43rd Annual Meeting of the Molecular Biology Society of Japan
- Data Source
  KAKENHI-PROJECT-23K20328
[Presentation] 日本における遺伝子治療研究開発の課題と展望2019
- Author(s)
  Okada T.
- Organizer
  Pall Gene Therapy Seminar
- Invited
- Data Source
  KAKENHI-PROJECT-26293328
[Presentation] Skin and Vascular Abnormalities in Chst14 Gene-Deleted Mice, an Animal Model of Musculocontractual Ehlers-Danlos Syndrome2019
- Author(s)
  Yoshizawa T, Mizumoto S, Takahashi Y, Shimada S, Sugahara K, Nakayama J, Takeda S, Nomura Y, Nitahara-Kasahara Y, Okada T, Matsumoto K, Yamada S, Kosho T
- Organizer
  Scientific Meeting on The Rare Types of Ehlers-Danlos Syndromes
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03616
[Presentation] CRISPR/Cas9-mediated development and characterization of knockout mice for musculocontractural type Ehlers-Danlos Syndrome caused by mutations in CHST14 (mcEDS-CHST14).2019
- Author(s)
  Nitahara-Kasahara Y, Tsumita N, Mizumoto S, Inoue Y, Inoue T, Yoshizawa T, Takahashi Y, Guillermo PH, Oda Y, Nakamura-Takahashi A, Hashimoto A, Nomura Y, Takeda S, Watanabe A, Kosho T, Okada T
- Organizer
  Scientific Meeting on The Rare Types of Ehlers-Danlos Syndromes
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03616
[Presentation] Improvement of lethal hypophosphatasia in mice by high level expression of bone targeted alkaline phosphatase using self-complementary AAV8 vector2018
- Author(s)
  Nakamura-Takahashi A, Ikeue R, Nitahara-Kasahara Y, Watanabe A, Hirai Y, Okada T, Kasahara M.
- Organizer
  第24回日本遺伝子細胞治療学会学術集会
- Data Source
  KAKENHI-PROJECT-26293328
[Presentation] Mesenchymal stem cells overexpressing interleukin-10 enhance neuroprotective effects in rat with transient focal ischemia.2018
- Author(s)
  Nakajima M, Nito C, Sowa K, Suda S, Nishiyama Y, Nakamura-Takahashi A, Nitahara-Kasahara Y, Imagawa K, Hirato T, Ueda M, Kimura K, Okada T.
- Organizer
  第24回日本遺伝子細胞治療学会学術集会
- Data Source
  KAKENHI-PROJECT-26293328
[Presentation] Enhancement of non-toxic HSV vector production and function by chemical compound treatment.2018
- Author(s)
  Kuroda S, Miyagawa Y, Adachi K, Yamamoto M, Hayashita-Kinoh H, Cohen JB, Glorioso JC, Suzuki H, Yoshida H, Okada T.
- Organizer
  第24回日本遺伝子細胞治療学会学術集会
- Data Source
  KAKENHI-PROJECT-16K15093
[Presentation] Development of AAV enabling oligodendrocyte-specific gene suppression: implication for the treatment of Pelizaeus-Merzbacher disease2018
- Author(s)
  Inoue K, Li H, Okada H, Goto Y-i, Okada T.
- Organizer
  11th FENS, Forum of Neuroscience
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293328
[Presentation] In vivo distribution of transgene expression from an HSV vector functionally deleted for all immediate-early genes2018
- Author(s)
  Miyagawa Y, Maruyama M, Kuroda S, Sakai A, Sato Y, Hayashita-kinoh H, Yamamoto M, Cohen JB, Glorioso JC, Okada T.
- Organizer
  The 41th Annual meeting of the Molecular Biology Society of Japan
- Data Source
  KAKENHI-PROJECT-16K15093
[Presentation] ラット局所脳虚血モデルにおいてHGF強発現歯髄幹細胞移植は血液脳関門障害を抑制し脳保護効果を増強する2018
- Author(s)
  岨康太, 仁藤智香子, 中島壯崇, 須田智, 西山康裕, 坂本悠記, 高橋有希, 笠原優子, 上田雅之, 岡田尚巳, 木村和美.
- Organizer
  第61回日本脳循環代謝学会学術集会
- Data Source
  KAKENHI-PROJECT-26293328
[Presentation] Transplantation of dental pulp stem cells overexpressing hepatocyte growth factor by adeno-associated virus vector in a rat stroke model.2018
- Author(s)
  Sowa K, Nito C, Nakajima M, Suda S, Nishiyama Y, Nakamura-Takahashi A, Nitahara-Kasahara Y, Imagawa K, Hirato T, Ueda M, Okada T, Kimura K.
- Organizer
  Nursing Symposium & Pre-Con
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293328
[Presentation] AAVベクターを用いた遺伝子治療とゲノム医療2018
- Author(s)
  Okada T.
- Organizer
  第50回日本臨床分子形態学会総会 Symposium 「ゲノムで見える病態」
- Invited
- Data Source
  KAKENHI-PROJECT-16K15093
[Presentation] Dental pulp stem cell overexpressing hepatocyte growth factor ameliorates blood-brain barrier permeability and promotes neuroprotection in a rat model of ischemic stroke.2018
- Author(s)
  Sowa K, Nito C, Nakajima M, Suda S, Nishiyama Y, Nakamura-Takahashi A, Nitahara-Kasahara Y, Imagawa K, Hirato T, Ueda M, Kimura K, Okada. T.
- Organizer
  第24回日本遺伝子細胞治療学会学術集会
- Data Source
  KAKENHI-PROJECT-26293328
[Presentation] AAV vector transduction strategy with immune-modulation to ameliorate　muscular dystrophy.2017
- Author(s)
  Takashi Okada
- Organizer
  The 23rd Annual Meeting of Japan Society of Gene and　Cell Therapy
- Invited
- Data Source
  KAKENHI-PROJECT-26293328
[Presentation] Transplantation of Mesenchymal Stem Cells Overexpressing IL-I0 by AAV l Vector in Rat Stroke Model.2017
- Author(s)
  Masataka Nakajim, Chikako Nito, Kota Sowa, Satoshi Suda, Yasuhiro Nishiyama, Aki Nakamura-Takahashi, Yuko Nitahara-Kasahara, Kiwamu Imagawa, Tohru Hirato, Masayuki Ueda, Kazumi Kimura, Takashi Okada.
- Organizer
  The 23rd Annual Meeting ofJapan Society of Gene and Cell Therapy
- Data Source
  KAKENHI-PROJECT-26293328
[Presentation] 難治性神経・筋疾患の遺伝子治療に向けた新規無毒化ヘルペスウイルスベクターの開発.2017
- Author(s)
  宮川世志幸、黒田誠司、丸山基世、喜納裕美、山本基子、Gianluca Verlengia、Michele Simonato、Justus Cohen、Joseph Glorioso、岡田尚巳
- Organizer
  2017年度生命科学系学会合同年次大会(ConBio2017)
- Invited
- Data Source
  KAKENHI-PROJECT-16K15093
[Presentation] Effect of culture conditions on efficient production of non-toxic herpes simplex virus-based vectors using a novel producer cell line.2017
- Author(s)
  Seiji Kuroda, Yoshitaka Miyagawa, Kumi Adachi, Motoko Yamaoto, Justus B. Cohen, Joseph C. Glorioso, Hideyuki Suzuki, Eiji Uchida and Takashi Okada.
- Organizer
  The 23rd Annual Meeting of Japan Society of Gene and Cell Therapy
- Data Source
  KAKENHI-PROJECT-16K15093
[Presentation] Effect of dental pulp stem cell overexpressing hepatocyte growth factor by adeno associated virus vector in a rat stroke model.2017
- Author(s)
  Kota Sowa, Chikako Nito, Masataka Nakajima, Satoshi Suda, Yasuhiro Nishiyama, Aki Nakamura-Takahashi, Yuko Nitahara-Kasahara, Kiwamu Imagawa, Tohru Hirato, Masayuki Ueda, Kazumi Kimura Takashi Okada.
- Organizer
  The 23rd Annual Meeting of Japan Society of Gene and Cell Therapy
- Data Source
  KAKENHI-PROJECT-26293328
[Presentation] Transduction of anterior segment is not affected by vitrectomy before triple-mutated scAAV2 vector injection into vitreous.2017
- Author(s)
  Kazuhisa Takahashi, Tsutomu Igarashi, Koichi Miyake, Maika Kobayashi, Chiemi Yaguchi, Osamu Iijima, Yoshiyuki Yamazaki, Noriko Miyake, Shuhei Kameya, Takashi Shimada, Hiroshi Takahashi, Takashi Okada.
- Organizer
  he 23rd Annual Meeting of Japan Society of Gene and Cell Therapy
- Data Source
  KAKENHI-PROJECT-26293328
[Presentation] AAVベクターを用いた筋ジストロフィーに対する遺伝子細胞治療2017
- Author(s)
  岡田尚巳
- Organizer
  第62回　日本人類遺伝学会　学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-26293328
[Presentation] Chromatography-based rAAV9 purifïcation protocol with ultracentrifugation-free procedure.2017
- Author(s)
  Taro Tomono, Yukihiko Hirai, Hironori Okada, Yoshitaka Miyagawa, Kumi Adachi, Shuhei Sakamoto, Yasuhiro Kawano, Hideto Chono, Junichi Mineno, Akiko Ishii, Takashi Shimada, Masahumi Onodera, Akira Tamaoka, and Takashi Okada.
- Organizer
  The 23rd Annual Meeting of Japan Society of Gene and Cell Therapy
- Data Source
  KAKENHI-PROJECT-26293328
[Presentation] クロマトグラフィー技術を用いた8型アデノ随伴ウイルスベクター(rAAV8) の精製.2017
- Author(s)
  伴野太郎、増田千明、宮川世志幸、岡田浩典、平井幸彦、石井亜紀子、玉岡晃、岡田尚巳.
- Organizer
  2017年度生命科学系学会合同年次大会(ConBio2017)
- Data Source
  KAKENHI-PROJECT-26293328
[Presentation] Development of flow electoporation-bascd suspension-adapted HEK293 transfection system toward rAAV production in GMP.2017
- Author(s)
  Hironori Okada, Taro Tomono, Kumi Adachi, Yukihiko Hirai，Masaaki Ouchi, YukoUtsunomiya, Hideto Chono, Junichi Mineno, Takashi Okada.
- Organizer
  The 23rd Annual Meeting of Japan Society of Gene and Cell Therapy
- Data Source
  KAKENHI-PROJECT-26293328
[Presentation] Ultracentrifugation-Free Chromatography-Mediated Purification of Recombinant Adeno-Associated Virus Serotype9 (rAAV9).2017
- Author(s)
  Taro Tomono, Yukihiko Hlrai, Hironori Okada, Yoshitaka Miyagawa， Kumi Adachi, Yasuhiro Kawano，Hideto Chono，Junichi Mineno, Akiko Ishii， Takashi Shimada, Masafumi Onodera, Akira Tamaoka, Takashi Okada.
- Organizer
  The 20th Annual Meeting of American Society of Gene & Cell Therapy
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293328
[Presentation] Protocol optimization for high-yield production of a non-toxic herpes simplex virus-based vector using a novel producer cell line2016
- Author(s)
  Kuroda S, Miyagawa Y, Adachi K, Yamamoto M, Cohen JB, Glorioso JC, Suzuki H, Uchida E and Okada T
- Organizer
  第３９回日本分子生物学会
- Place of Presentation
  横浜
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-16K15093
[Presentation] Transient Ultrasound-Mediated Microbubble-Assisted Modulation of Blood-Brain Interface in Adult Common Marmoset to Improve rAAV-Mediated Brain Transduction2016
- Author(s)
  Okada H, Ishibashi H, Masuda C, Hayashita-Kinoh H, Chiyo T, Nitahara-Kasahara Y, Endo-Takahashi Y, Kato K, Negishi Y, Takeda S, Okada T
- Organizer
  American society of gene & cell therapy 19th Annual meeting
- Place of Presentation
  Washington DC, USA
- Year and Date
  2016-05-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26430102
[Presentation] 遺伝子細胞治療研究の進歩と展望2016
- Author(s)
  岡田尚巳
- Organizer
  Total Care Management Forum 91
- Place of Presentation
  金沢
- Invited
- Data Source
  KAKENHI-PROJECT-26293328
[Presentation] Feasibility of large-scale rAAV production from suspension HEK293 cell line using flow electroporation system2016
- Author(s)
  Okada H., Tomono T., Adachi K., Hirai Y., Okada T
- Organizer
  The 22nd Annual Meeting of Japan Society of Gene and Cell Therapy
- Place of Presentation
  東京
- Year and Date
  2016-07-28
- Data Source
  KAKENHI-PROJECT-26430102
[Presentation] Simple and effective ultracentrifugation-free large-scale purification of recombinant adeno-associated virus serotype 9 (rAAV9)2016
- Author(s)
  Tomono T., Hirai Y., Okada H., Adachi K., Sakamoto S., Kawano Y., Chono H., Mineno J., Ishii A., Shimada T., Onodera M., Tamaoka A., Okada T
- Organizer
  The 22nd Annual Meeting of Japan Society of Gene and Cell Therapy
- Place of Presentation
  東京
- Year and Date
  2016-07-28
- Data Source
  KAKENHI-PROJECT-26430102
[Presentation] Cell therapeutic approach using dental pulp stromal cells for Duchenne muscular dystrophy2016
- Author(s)
  Nitahara-Kasahara Y., Kuraoka M., Hayashita-Kinoh H., Nakamura-Takahashi A., Masuda C., Imagawa K., Tachibana K., Takeda S., Okada T
- Organizer
  The 22nd Annual Meeting of Japan Society of Gene and Cell Therapy
- Place of Presentation
  東京
- Year and Date
  2016-07-28
- Data Source
  KAKENHI-PROJECT-26430102
[Presentation] ラット局所脳虚血モデルにおけるHGF強発現歯髄幹細胞移植の治療効果2016
- Author(s)
  岨康太、仁藤智香子、中島壯崇、須田智、坂本悠記、西山康裕、上田雅之、高橋有希、笠原優子、今川究、立花克彦、岡田尚巳、木村和美
- Organizer
  第59回日本脳循環代謝学会学術集会
- Place of Presentation
  徳島
- Year and Date
  2016-11-11
- Data Source
  KAKENHI-PROJECT-26293328
[Presentation] Ultracentrifugation-Free Chromatography-Mediated Large-Scale Purification of Recombinant Adeno- Associated Virus Serotype 1 (rAAV1) and rAAV9 from the Serum-Free Culture Supernatant2016
- Author(s)
  Tomono T, Hirai Y, Okada H, Adachi K, Ishii A, Shimada T, Onodera M, Tamaoka A, Okada T
- Organizer
  American society of gene & cell therapy 19th Annual meeting
- Place of Presentation
  Washington DC, USA
- Year and Date
  2016-05-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26430102
[Presentation] Improved Transduction of Canine X-Linked Muscular Dystrophy with rAAV9-Microdystrophin by Introducing Immune Tolerance2016
- Author(s)
  Hayashita-Kinoh H, Okada H, N. Kasahara Y, Chiyo T, Imagawa K, Tachibana K, Takeda S, Okada T
- Organizer
  American society of gene & cell therapy 19th Annual meeting
- Place of Presentation
  Washington DC, USA
- Year and Date
  2016-05-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26430102
[Presentation] AAVベクターを用いたPABPN1優性阻害変異体発現によるマーモセット眼咽頭型筋ジストロフィーモデルの作製2016
- Author(s)
  岡田浩典、石橋英俊、喜納裕美、増田千明、笠原優子、武田伸一、岡田尚巳
- Organizer
  第2回日本筋学会学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-26293328
[Presentation] Effective microdystrophin expression in non-human primate muscle with AAV type 8 vectors under immune suppression2016
- Author(s)
  Ishii A., Okada H., Hayashita-Kinoh H., Shin J. H., Okada T., Takeda S
- Organizer
  The 22nd Annual Meeting of Japan Society of Gene and Cell Therapy
- Place of Presentation
  東京
- Year and Date
  2016-07-28
- Data Source
  KAKENHI-PROJECT-26430102
[Presentation] Neuroprotective effects of intravenous administration of dental pulp stem cells after ischemic-reperfusion injury.2016
- Author(s)
  Chikako Nito，Kota sowa， Masataka Nakajima，Masayuki Ueda1，Yasuhiro Nishiyama1， Satoshi Suda，Aki N Takahashi，Kiwamu Imagawa，Katsuhiko Tachibana， Yuko N Kasahara，Kazumi Kimura1，Takashi Okada.
- Organizer
  The 22nd Annual Meeting of Japan Society of Gene and Cell Therapy
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-26293328
[Presentation] Attractive characteristics of scAAV vectors and improved methods for efficient production,2016
- Author(s)
  Takashi Okada
- Organizer
  The 22nd Annual Meeting of Japan Society of Gene and Cell Therapy
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-26293328
[Presentation] Systemic administration of rAAV9-microdystrophin with MSCs pre-treatment improves transgene expression and phenotype in CXMDJ2016
- Author(s)
  Hayashita-Kinoh H., Nitahara-Kasahara Y., Kuraoka M., Okada H., Imagawa K., Tachibana K., Takeda S., Okada T
- Organizer
  The 22nd Annual Meeting of Japan Society of Gene and Cell Therapy
- Place of Presentation
  東京
- Year and Date
  2016-07-28
- Data Source
  KAKENHI-PROJECT-26430102
[Presentation] Enzyme replacement in the CSF to treat metachromatic leukodystrophy in mouse model using single intracerebroventricular injection of adeno-associated virus vector.2016
- Author(s)
  廣中浩平、山崎吉之、平井幸彦、山本基子、三宅紀子、三宅弘一、島田隆、岡田尚巳、喜多村孝幸、森田明夫
- Organizer
  日本脳神経外科学会第75回学術総会
- Place of Presentation
  福岡
- Year and Date
  2016-09-29
- Data Source
  KAKENHI-PROJECT-26293328
[Presentation] AAVベクターを用いた遺伝子治療の現状と課題2016
- Author(s)
  岡田尚巳
- Organizer
  第1回日本遺伝子細胞治療学会若手研究会セミナー
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-26293328
[Presentation] Blood-Brain Interface Opening By Ultrasound in Adult Common Marmoset To Induce Brain Pathology With rAAV.2015
- Author(s)
  Okada H, Ishibashi H, Masuda C, Hayashita-Kinoh H, Chiyo T, Nitahara-Kasahara Y, Endo-Takahashi Y, Kato K, Negishi Y, Takeda S, Okada T.
- Organizer
  18th Annual Meeting of American Society of Gene & Cell Therapy
- Place of Presentation
  New Orleans
- Year and Date
  2015-05-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293328
[Presentation] Prolonged Survival and Improved Phenotypes of Lethal Hypophosphatasia Model Mice By Adeno-Associated Virus-Mediated Muscle Transduction of Bone-Targeted Alkaline Phosphatase.2015
- Author(s)
  Nakamura A, Miyake K, Watanabe A, Hirai, Y Miyake N, Iijima O, Adachi K, Kinoshita H, Noguchi T, Abe S, Shimada T, Okada T.
- Organizer
  18th Annual Meeting of American Society of Gene & Cell Therapy
- Place of Presentation
  New Orleans
- Year and Date
  2015-05-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293328
[Presentation] Mesenchymal Stromal Cells Can Ameliorate the Progressive Phenotype of Dog With Duchenne Muscular Dystrophy.2015
- Author(s)
  Nitahara-Kasahara Y, Hayashita-Kinoh H, Kuraoka M, Chiyo T, Okada H, Tsumita N, Imagawa K, Tachibana K, Takeda S, Okada T
- Organizer
  18th Annual Meeting of American Society of Gene & Cell Therapy
- Place of Presentation
  New Orleans, LA, USA
- Year and Date
  2015-05-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26430102
[Presentation] Improved transduction of canine X-linked muscular dystrophy with rAAV9- microdystrophin by MSCs pretreatment Improved transduction of canine X-linked muscular dystrophy with rAAV9- microdystrophin by MSCs pretreatment.2015
- Author(s)
  Hayashita-Kinoh H., Nitahara-Kasahara Y., Okada H., Chiyo T., Imagawa K., Tachibana K., Takeda S.,Okada T.
- Organizer
  The 21st Annual Meeting of Japan Society of Gene Therapy
- Place of Presentation
  大阪
- Year and Date
  2015-07-25
- Data Source
  KAKENHI-PROJECT-26293328
[Presentation] Feasible gene transduction in non-human primate muscle with reconbinant AAV following immunomodulation.2015
- Author(s)
  Ishii A., Okada H., Hayashita-Kinoh H., Shin J. H., Okada T., Takeda S.
- Organizer
  The 21st Annual Meeting of Japan Society of Gene Therapy
- Place of Presentation
  大阪
- Year and Date
  2015-07-25
- Data Source
  KAKENHI-PROJECT-26293328
[Presentation] The large-scale purification of rAAV1 from the serum-free cultured medium by ion-exchange and gel-filtration chromatography-steps with ultracentrifugation-free technique.2015
- Author(s)
  Tomono T., Hirai Y., Okada H., Adachi K., Chiyo T., Ishii A., Shimada T., Onodera M., Tamaoka A.,Okada T.
- Organizer
  The 21st Annual Meeting of Japan Society of Gene Therapy
- Place of Presentation
  大阪
- Year and Date
  2015-07-24
- Data Source
  KAKENHI-PROJECT-26293328
[Presentation] Mesenchymal stromal cells ameliorate progressive phenotype of Duchenne muscular dystrophy in dog.2015
- Author(s)
  Kasahara Y., Kinoh H., Kuraoka M., Chiyo T., Okada H., Tsumita N., Imagawa K., Tachibana K.,Takeda S., Okada T.
- Organizer
  The 21st Annual Meeting of Japan Society of Gene Therapy
- Place of Presentation
  大阪
- Year and Date
  2015-07-24
- Data Source
  KAKENHI-PROJECT-26293328
[Presentation] Successful treatment of neonatal metachromatic leukodystrophy model mice by intravenous injection of self-complementary AAV type 9 vector expressing ASA.2015
- Author(s)
  Miyake N., Miyake K., Yamamoto M., Shimada T., Okada T.
- Organizer
  The 21st Annual Meeting of Japan Society of Gene Therapy
- Place of Presentation
  大阪
- Year and Date
  2015-07-25
- Data Source
  KAKENHI-PROJECT-26293328
[Presentation] Improved Transduction of Canine X-Linked Muscular Dystrophy With rAAV9-Microdystrophin By Using MSCs Pretreatment.2015
- Author(s)
  Hayashita-Kinoh H, Okada H, Nitahara-Kasahara Y, Chiyo T, Imagawa K, Tachibana K, Takeda S, Okada T
- Organizer
  18th Annual Meeting of American Society of Gene & Cell Therapy
- Place of Presentation
  New Orleans, LA, USA
- Year and Date
  2015-05-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26430102
[Presentation] Ultrasound-mediated transient modulation of blood-brain interface in adult common marmosetto induce brain pathology with rAAV.2015
- Author(s)
  Okada H, Ishibashi H, Masuda C, Hayashita-Kinoh H, Chiyo T, Nitahara-Kasahara Y, Endo-Takahashi Y, Kato K, Negishi Y, Takeda S, Okada T
- Organizer
  The 21st Annual Meeting of Japan Society of Gene Therapy
- Place of Presentation
  大阪
- Year and Date
  2015-07-24
- Data Source
  KAKENHI-PROJECT-26430102
[Presentation] Gene therapy to rescue lethal hypophosphatasia model mice by adeno-associated virus-mediated muscle transduction of bone-targeted alkaline phosphatase.2015
- Author(s)
  Nakamura A., Miyake K., Watanabe A., Hirai Y., Miyake N., Iijima O., Adachi K., Kinoshita H.,Noguchi T., Abe S., Shimada T., Okada T.
- Organizer
  The 21st Annual Meeting of Japan Society of Gene Therapy
- Place of Presentation
  大阪
- Year and Date
  2015-07-25
- Data Source
  KAKENHI-PROJECT-26293328
[Presentation] The large-scale purification of rAAV1 from the serum-free cultured medium by ion-exchange and gel-filtration chromatography-steps with ultracentrifugation-free technique.2015
- Author(s)
  Tomono T, Hirai Y, Okada H, Adachi K, Chiyo T, Ishii A, Shimada T, Onodera M, Tamaoka A, Okada T
- Organizer
  The 21st Annual Meeting of Japan Society of Gene Therapy
- Place of Presentation
  大阪
- Year and Date
  2015-07-24
- Data Source
  KAKENHI-PROJECT-26430102
[Presentation] アデノ随伴ウイルスベクターの基盤技術開発と筋ジストロフィー遺伝子細胞治療への応用2015
- Author(s)
  岡田尚巳
- Organizer
  大阪大学大学院医学系研究科セミナー
- Place of Presentation
  大阪
- Year and Date
  2015-07-22
- Invited
- Data Source
  KAKENHI-PROJECT-26293328
[Presentation] Protection of the retina in rat retinal ischemic injury model by triple mutant AAV2-mediated BDNF transduction.2015
- Author(s)
  Kobayashi M., Igarashi T., Miyake K., Miyake N., Iijima O., Nakamoto K., Hirai Y., Takahashi H.,Okada T.
- Organizer
  The 21st Annual Meeting of Japan Society of Gene Therapy
- Place of Presentation
  大阪
- Year and Date
  2015-07-25
- Data Source
  KAKENHI-PROJECT-26293328
[Presentation] AAVベクター基盤技術の開発と遺伝子細胞治療への応用2015
- Author(s)
  岡田尚巳
- Organizer
  第25回遺伝子治療推進産学懇話会
- Place of Presentation
  東京
- Year and Date
  2015-11-13
- Invited
- Data Source
  KAKENHI-PROJECT-26293328
[Presentation] Blood-Brain Interface Opening By Ultrasound in Adult Common Marmoset To Induce Brain Pathology With rAAV.2015
- Author(s)
  Okada H, Ishibashi H, Masuda C, Hayashita-Kinoh H, Chiyo T, Nitahara-Kasahara Y, Endo-Takahashi Y, Kato K, Negishi Y, Takeda S, Okada T
- Organizer
  18th Annual Meeting of American Society of Gene & Cell Therapy
- Place of Presentation
  New Orleans, LA, USA
- Year and Date
  2015-05-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26430102
[Presentation] Ultrasound-mediated transient modulation of blood-brain interface in adult common marmosetto induce brain pathology with rAAV.2015
- Author(s)
  Okada H., Ishibashi H., Masuda C., Hayashita-Kinoh H., Chiyo T., Nitahara-Kasahara Y.,Endo-Takahashi Y., Kato K., Negishi Y., Takeda S., Okada T.
- Organizer
  The 21st Annual Meeting of Japan Society of Gene Therapy
- Place of Presentation
  大阪
- Year and Date
  2015-07-24
- Data Source
  KAKENHI-PROJECT-26293328
[Presentation] Mesenchymal Stromal Cells Can Ameliorate the Progressive Phenotype of Dog With Duchenne Muscular Dystrophy.2015
- Author(s)
  Nitahara-Kasahara Y, Hayashita-Kinoh H, Kuraoka M, Chiyo T, Okada H, Tsumita N, Imagawa K, Tachibana K, Takeda S, Okada T.
- Organizer
  18th Annual Meeting of American Society of Gene & Cell Therapy
- Place of Presentation
  New Orleans
- Year and Date
  2015-05-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293328
[Presentation] アデノ随伴ウイルスベクターの脳室内注入による異染性白質ジストロフィーモデルマウスの遺伝子治療2015
- Author(s)
  廣中浩平、山崎吉之、平井幸彦、山本基子、三宅紀子、三宅弘一、森田明夫、島田隆、岡田尚巳
- Organizer
  第20回日本ライソゾーム病研究会
- Place of Presentation
  東京
- Year and Date
  2015-10-02
- Data Source
  KAKENHI-PROJECT-26293328
[Presentation] アデノ随伴ウイルスベクターを応用した細胞遺伝子治療2015
- Author(s)
  岡田尚巳
- Organizer
  第14回日本再生医療学会シンポジウム
- Place of Presentation
  横浜
- Year and Date
  2015-03-21
- Invited
- Data Source
  KAKENHI-PROJECT-26293328
[Presentation] Improved transduction of canine X-linked muscular dystrophy with rAAV9- microdystrophin by MSCs pretreatment Improved transduction of canine X-linked muscular dystrophy with rAAV9- microdystrophin by MSCs pretreatment.2015
- Author(s)
  Hayashita-Kinoh H, Nitahara-Kasahara Y, Okada H, Chiyo T, Imagawa K, Tachibana K, Takeda S, Okada T
- Organizer
  The 21st Annual Meeting of Japan Society of Gene Therapy
- Place of Presentation
  大阪
- Year and Date
  2015-07-24
- Data Source
  KAKENHI-PROJECT-26430102
[Presentation] NMJ-enlarging therapy for neuromuscular diseases.2015
- Author(s)
  Arimura S., Okada T., Tezuka T., Chiyo T., Kasahara Y., Yoshimura T., Motomura M., Yoshida N.,Beeson D., Yamanashi Y.
- Organizer
  The 21st Annual Meeting of Japan Society of Gene Therapy
- Place of Presentation
  大阪
- Year and Date
  2015-07-25
- Data Source
  KAKENHI-PROJECT-26293328
[Presentation] Efficient Scalable Purification of rAAV1 Using Ion-Exchange and Gel-Filtration Chromatography To Avoid Ultracentrifugation Procedure.2015
- Author(s)
  Tomono T, Hirai Y, Okada H, Chiyo T, Shimada T, Onodera M, Okada T
- Organizer
  18th Annual Meeting of American Society of Gene & Cell Therapy
- Place of Presentation
  New Orleans, LA, USA
- Year and Date
  2015-05-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26430102
[Presentation] Efficient Scalable Purification of rAAV1 Using Ion-Exchange and Gel-Filtration Chromatography To Avoid Ultracentrifugation Procedure.2015
- Author(s)
  Tomono T, Hirai Y, Okada H, Chiyo T, Shimada T, Onodera M, Okada T.
- Organizer
  18th Annual Meeting of American Society of Gene & Cell Therapy
- Place of Presentation
  New Orleans
- Year and Date
  2015-05-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293328
[Presentation] Feasible gene transduction in non-human primate muscle with reconbinantAAV following immunomodulation.2015
- Author(s)
  Ishii A, Okada H, Hayashita-Kinoh H, Shin J, Okada T, Takeda S
- Organizer
  The 21st Annual Meeting of Japan Society of Gene Therapy
- Place of Presentation
  大阪
- Year and Date
  2015-07-24
- Data Source
  KAKENHI-PROJECT-26430102
[Presentation] 神経筋疾患に対する細胞遺伝子治療基盤技術開発2015
- Author(s)
  岡田尚巳
- Organizer
  第39回関東機能的脳外科カンファレンス
- Place of Presentation
  東京
- Year and Date
  2015-04-04
- Invited
- Data Source
  KAKENHI-PROJECT-26293328
[Presentation] Improved Transduction of Canine X-Linked Muscular Dystrophy With rAAV9-Microdystrophin By Using MSCs Pretreatment.2015
- Author(s)
  Hayashita-Kinoh H, Okada H, Nitahara-Kasahara Y, Chiyo T, Imagawa K, Tachibana K, Takeda S, Okada T.
- Organizer
  18th Annual Meeting of American Society of Gene & Cell Therapy
- Place of Presentation
  New Orleans
- Year and Date
  2015-05-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293328
[Presentation] Mesenchymal stromal cells ameliorate progressive phenotype of Duchenne muscular dystrophy in dog.2015
- Author(s)
  Kasahara Y, Kinoh H, Kuraoka M, Chiyo T, Okada H, Tsumita N, Imagawa K, Tachibana K, Takeda S, Okada T
- Organizer
  The 21st Annual Meeting of Japan Society of Gene Therapy
- Place of Presentation
  大阪
- Year and Date
  2015-07-24
- Data Source
  KAKENHI-PROJECT-26430102
[Presentation] デュシェンヌ型筋ジストロフィー・イヌモデルCXMDJを用いた血清オステオポンチンの解析2014
- Author(s)
  倉岡睦季1、木村円1, 2、永田哲也1、岡田尚巳1,3、今村道博1、武田伸一1, 2
- Organizer
  第9回筋ジストロフィー治療研究合同発表会
- Place of Presentation
  箱根
- Year and Date
  2014-11-01
- Data Source
  KAKENHI-PROJECT-24659265
[Presentation] Engraftment of Mesenchymal Stromal Cells That CanDifferentiate To Form Myogenic Cells Is Enhancedby Expressing IL-10 in Dog with Duchenne MuscularDystrophy2013
- Author(s)
  Nitahara-Kasahara Y, Hayashita-Kinoh H, Chiyo T, Okada H, Okada T, Takeda S
- Organizer
  American society of gene & cell therapy 16th Annual meeting
- Place of Presentation
  Salt Lake City, Utah, USA
- Data Source
  KAKENHI-PROJECT-24659265
[Presentation] Immune Tolerance Induction in Canine X-LinkedMuscular Dystrophy with Trans-Placental rAAV9-Microdystrophin Transduction2013
- Author(s)
  Hayashita-Kinoh H, Okada H, Nitahara-Kasahara Y, Chiyo T, Yugeta N, Okada T, Takeda S
- Organizer
  American society of gene & cell therapy 16th Annual meeting
- Place of Presentation
  Salt Lake City,Utah,USA
- Data Source
  KAKENHI-PROJECT-22390284
[Presentation] Effective Transduction of Connon Marmoset with rAAV1 and 9 To Generate NHP Model of Muscular Dystrophy2013
- Author(s)
  1. Okada H, Ishibashi H, Hayashita-Kinoh H, Chiyo T, Nitahara-Kasahara Y, Okada T, Takeda S
- Organizer
  American society of gene & cell therapy 16th Annual meeting
- Place of Presentation
  Salt Lake City,Utah,USA
- Data Source
  KAKENHI-PROJECT-22390284
[Presentation] AAV vector-mediated micro-dystrophin transduction with immune-modulation to improve DMD phenotype2012
- Author(s)
  Takashi Okada
- Organizer
  9th Japanese-French Symposium for muscular dystrophy
- Place of Presentation
  Tokyo, JA Kyosai Building Conference Hall
- Invited
- Data Source
  KAKENHI-PROJECT-22390284
[Presentation] Strategy for rAAV9-Mediated Transduction of Common Marmoset Skeletal Muscle To Generate NHP DMD2012
- Author(s)
  Hironori Okada
- Organizer
  American society of gene & cell therapy 15th Annual meeting
- Place of Presentation
  Philadelphia, USA; Pennsylvania Convention Center
- Data Source
  KAKENHI-PROJECT-22390284
[Presentation] 遺伝子治療基盤技術の開発と応用2011
- Author(s)
  岡田尚巳
- Organizer
  NCNPてんかんセンターリサーチカンファランス
- Place of Presentation
  NCNP,東京
- Year and Date
  2011-04-14
- Data Source
  KAKENHI-PROJECT-22390284
[Presentation] 筋ジストロフィーモデルマーモセットの開発2011
- Author(s)
  岡田尚巳
- Organizer
  精神・神経疾患開発費「精神・神経・筋疾患の解明のための霊長類モデル開発に関する研究」(主任研究者関和彦)平成23年度班会議
- Place of Presentation
  NCNP,東京
- Year and Date
  2011-12-21
- Data Source
  KAKENHI-PROJECT-22390284
[Presentation] 遺伝子治療基盤技術の開発と神経筋疾患治療への応用2011
- Author(s)
  岡田尚巳
- Organizer
  国立精神・神経医療研究センター病院ニューロサイエンスセミナー
- Place of Presentation
  国立精神・神経医療研究センター/小平
- Year and Date
  2011-01-31
- Data Source
  KAKENHI-PROJECT-22390284
[Presentation] Distruption of common marmoset dystrophin mRNA to generate non-human primate DMD model2011
- Author(s)
  Okada H
- Organizer
  第17回日本遺伝子治療学会学術集会
- Place of Presentation
  九州大学医学部百年講堂,福岡
- Year and Date
  2011-07-16
- Data Source
  KAKENHI-PROJECT-22390284
[Presentation] Scalable purification of AAV1 and AAV8 vectors using dual ion-exchange adsorptive membranes2010
- Author(s)
  岡田尚巳
- Organizer
  日本遺伝子治療学会第1回遺伝子治療研究奨励賞受賞講演第16回日本遺伝子治療学会学術集会
- Place of Presentation
  宇都宮、栃木県総合文化センター
- Year and Date
  2010-07-01
- Data Source
  KAKENHI-PROJECT-19390383
[Presentation] Efficient gene transfer into neurons in the primate brain via antero- and retrograde infections by adeno-associated virus serotype 8 and 92010
- Author(s)
  Masamizu Y., Okada T., Kawasaki K., Ishibashi H., Takeda S., Yuasa S., Hasegawa I. & Nakahara K
- Organizer
  Neuroscience 2010
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-22500371
[Presentation] 遺伝性筋疾患に対する幹細胞治療の現状とこれから～幹細胞で何ができるのか～2010
- Author(s)
  岡田尚巳
- Organizer
  世界脳週間2010公開講座
- Place of Presentation
  ルネこだいら/小平
- Year and Date
  2010-05-22
- Data Source
  KAKENHI-PROJECT-22390284
[Presentation] Efficient gene transfer into neurons in the primate brain via antero and etrograde infections by adeno-associated virus serotype 8 and 9.2010
- Author(s)
  正水芳人、岡田尚巳、川嵜圭祐、石橋英俊、武田伸一、湯浅茂樹、長谷川功、中原潔
- Organizer
  40^<th> annual meeting of the society for neuroscience
- Place of Presentation
  San Diego Convention Center San Diego, USA
- Year and Date
  2010-11-16
- Data Source
  KAKENHI-PROJECT-22500371
[Presentation] Attractive features of AAV vectors and methods for efficient production.2010
- Author(s)
  岡田尚巳
- Organizer
  第16回日本遺伝子治療学会
- Place of Presentation
  栃木県総合文化センター/宇都宮
- Year and Date
  2010-07-02
- Data Source
  KAKENHI-PROJECT-22390284
[Presentation] Scalable purification of AAV1 and AAV8 vectors using dual ion-exchange adsorptive membranes2010
- Author(s)
  岡田尚巳
- Organizer
  日本遺伝子治療学会第1回遺伝子治療研究奨励賞受賞講演第16回日本遺伝子治療学会学術集会
- Place of Presentation
  宇都宮、栃木県総合文化センター
- Year and Date
  2010-07-01
- Data Source
  KAKENHI-PROJECT-19390383
[Presentation] ウイルスベクターを用いたコモンマーモセット筋ジストロフィーモデル動物の開発2010
- Author(s)
  岡田尚巳
- Organizer
  精神・神経疾患研究開発費「精神神経疾患の解明のための霊長類モデル開発に関する研究」(主任研究者中村克樹)平成22年度班会議
- Place of Presentation
  京都大学霊長類研究所/犬山
- Year and Date
  2010-11-11
- Data Source
  KAKENHI-PROJECT-22390284
[Presentation] ベクター産生型骨髄間質細胞を利用した遺伝子治療2010
- Author(s)
  岡田尚巳, 他
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山コンベンションセンター、岡山
- Year and Date
  2010-03-30
- Data Source
  KAKENHI-PROJECT-19390383
[Presentation] Gene transfer into the primate central nervous system via antero- and retrograde infections by adeno-associated viruses2010
- Author(s)
  Masamizu Y., Okada T., Kawasaki K., Ishibashi H., Takeda S., Yuasa S., Hasegawa I. and Nakahara K
- Organizer
  Neuro2010
- Place of Presentation
  Kobe
- Data Source
  KAKENHI-PROJECT-22500371
[Presentation] ベクター産生型骨髄間質細胞を利用した遺伝子治療2010
- Author(s)
  岡田尚巳
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山、岡山コンベンションセンター
- Year and Date
  2010-03-30
- Data Source
  KAKENHI-PROJECT-19390383
[Presentation] Scalable purification of AAV1 and AAV8 vectors using dualion-exchange adsorptive membranes.2010
- Author(s)
  岡田尚巳
- Organizer
  遺伝子治療研究奨励賞講演,第16回日本遺伝子治療学会
- Place of Presentation
  栃木県総合文化センター/宇都宮
- Year and Date
  2010-07-01
- Data Source
  KAKENHI-PROJECT-22390284
[Presentation] 幹細胞の機能制御と難病治療への応用2009
- Author(s)
  岡田尚巳
- Organizer
  第7回遺伝子治療シンポジウム
- Place of Presentation
  大阪
- Year and Date
  2009-01-30
- Data Source
  KAKENHI-PROJECT-19659144
[Presentation] AAVベクターを用いた筋ジストロフィーに対する遺伝子治療2009
- Author(s)
  岡田尚巳, 他
- Organizer
  日本人類遺伝学会第54回大会
- Place of Presentation
  グランドプリンスホテル高輪、東京
- Year and Date
  2009-09-24
- Data Source
  KAKENHI-PROJECT-19390383
[Presentation] Development of AAV vector production system and therapeutic approaches for Duchenne muscular dystrophy2009
- Author(s)
  岡田尚巳, 他
- Organizer
  熊本大学グローバルCOEリエゾンラボ研究会
- Place of Presentation
  熊本大学発生医学研究所、熊本
- Year and Date
  2009-11-11
- Data Source
  KAKENHI-PROJECT-19390383
[Presentation] Development of AAV vector production system and therapeutic approaches for Duchenne muscular dystrophy2009
- Author(s)
  岡田尚巳
- Organizer
  熊本大学グローバルCOEリエゾンラボ研究会
- Place of Presentation
  熊本、熊本大学
- Year and Date
  2009-11-11
- Data Source
  KAKENHI-PROJECT-19390383
[Presentation] AAVベクターを用いた筋ジストロフィーに対する遺伝子治療2009
- Author(s)
  岡田尚巳,喜納裕美,笠原優子,岡田浩典,武田伸一
- Organizer
  日本人類遺伝学会第54回大会
- Place of Presentation
  東京、グランドプリンスホテル高輪
- Year and Date
  2009-09-24
- Data Source
  KAKENHI-PROJECT-19390383
[Presentation] AAVベクター作製法の工夫と筋疾患遺伝子治療への応用2008
- Author(s)
  岡田尚巳
- Organizer
  日本医科大学ハイテクリサーチセンターセミナー
- Place of Presentation
  東京
- Year and Date
  2008-06-23
- Data Source
  KAKENHI-PROJECT-19390383
[Presentation] 生活習慣病・神経筋疾患に対する細胞遺伝子治療の開発2008
- Author(s)
  岡田尚巳
- Organizer
  第12回小児分子内分泌研究会
- Place of Presentation
  小樽
- Year and Date
  2008-07-05
- Data Source
  KAKENHI-PROJECT-19659144
[Presentation] AAVベクターの作製と筋疾患遺伝子治療への応用2008
- Author(s)
  岡田尚巳
- Organizer
  第14回日本遺伝子治療学会学術集会
- Place of Presentation
  札幌
- Year and Date
  2008-06-13
- Data Source
  KAKENHI-PROJECT-19390383
[Presentation] 生活習慣病・神経筋疾患に対する細胞遺伝子治療の開発2008
- Author(s)
  岡田尚巳
- Organizer
  第12回小児分子内分泌研究会
- Place of Presentation
  小樽、ヒルトン小樽
- Year and Date
  2008-07-05
- Data Source
  KAKENHI-PROJECT-19390383
[Presentation] rAAV1 and 8-mediated induction of local OPMD histopathology in common marmotset.
- Author(s)
  Hironori Okada, Hidetoshi Ishibashi, Hiromi Hayashita-Kinoh, Tomoko Chiyo, Yuko Nitahara-Kasahara, Shin’ichi Takeda, Takashi Okada.
- Organizer
  The 20th Annual Meeting of Japan Society of Gene Therapy
- Place of Presentation
  Tokyo
- Year and Date
  2014-08-06 – 2014-08-08
- Data Source
  KAKENHI-PROJECT-26293328
[Presentation] rAAV1 and 8-mediated induction of local OPMD histopathology in common marmotset.
- Author(s)
  Okada H, Ishibashi H, Hayashita-Kinoh H, Chiyo T, Nitahara-Kasahara Y, Takeda S, Okada T
- Organizer
  The 20th Annual Meeting of Japan Society of Gene Therapy
- Place of Presentation
  東京
- Year and Date
  2014-08-06 – 2014-08-08
- Data Source
  KAKENHI-PROJECT-26430102
[Presentation] Good manufacturing practice (GMP) compatible method for adeno-associated virus type2 vector production and purification
- Author(s)
  Shuhei Sakamoto, Toshikazu Nishie, Hikaru Takakura, Tatsuji Enoki, Junichi Mineno, Takashi Okada, Takanori Yamagata, Hiroaki Mizukami, Keiya Ozawa, Shin-ichi Muramatsu
- Organizer
  第20回日本遺伝子治療学会（JSGT)学術集会
- Place of Presentation
  Tokyo
- Year and Date
  2014-08-06 – 2014-08-08
- Data Source
  KAKENHI-PROJECT-26293328
[Presentation] IL-10強制発現による機能強化型MSCsの作製と生存解析.
- Author(s)
  笠原優子, 喜納裕美, 千代智子, 岡田浩典, 武田伸一, 岡田尚巳
- Organizer
  第35回日本炎症・再生医学会
- Place of Presentation
  沖縄
- Year and Date
  2014-07-01 – 2014-07-04
- Data Source
  KAKENHI-PROJECT-26430102
[Presentation] Skeletal muscle engraftment of mesenchymal stromal cells is augmented by IL-10.
- Author(s)
  Yuko Nitahara-Kasahara, Hiromi Hayashita-Kinoh, Tomoko Chiyo, Hironori Okada, Shin’ichi Takeda, Takashi Okada.
- Organizer
  American Society of Gene and Cell Therapy 17th Annual Meeting
- Place of Presentation
  Washington, DC
- Year and Date
  2014-05-21 – 2014-05-24
- Data Source
  KAKENHI-PROJECT-24659265
[Presentation] Induction of local OPMD histopathology in common marmotset by rAAV1 and 8-mediated transduction.
- Author(s)
  Hironori Okada, Hidetoshi Ishibashi, Hiromi Hayashita-Kinoh, Tomoko Chiyo, Chiaki Masuda, Yuko Nitahara-Kasahara, Shin’ichi Takeda and Takashi Okada.
- Organizer
  ASGCT 17th Annual Meeting
- Place of Presentation
  DC, USA
- Year and Date
  2014-05-21 – 2014-05-24
- Data Source
  KAKENHI-PROJECT-26293328
[Presentation] Effective microdystrophin expression in non-human primate muscle with rAAV type 2/8/9 vectors following immune suppression.
- Author(s)
  Akiko Ishii, Hironori Okada, Hiromi Hayashita-Kinoh, Shin Jin-Hong, Takashi Okada, Shin’ichi Takeda.
- Organizer
  The 20th Annual Meeting of Japan Society of Gene Therapy
- Place of Presentation
  Tokyo
- Year and Date
  2014-08-06 – 2014-08-08
- Data Source
  KAKENHI-PROJECT-24659265
[Presentation] Immune tolerance induction of canine X-linked muscular dystrophy with fetal rAAV-microdystrophin transduction.
- Author(s)
  Hiromi Hayashita-Kinoh, Hironori Okada, Yuko Nitahara-Kasahara, Tomoko Chiyo, Naoko Yugeta, Takashi Okada, Shin’ichi Takeda.
- Organizer
  The 20th Annual Meeting of Japan Society of Gene Therapy
- Place of Presentation
  Tokyo
- Year and Date
  2014-08-06 – 2014-08-08
- Data Source
  KAKENHI-PROJECT-24659265
[Presentation] Examination on large scale production of AAV vectors for clinical use
- Author(s)
  Toshikazu Nishie, Tatsuji Enoki, Masanari Kitagawa, Junichi Mineno, Takashi Okada, Tsukasa Ohmori, Hiroaki Mizukami, Keiya Ozawa, Yoichi Sakata
- Organizer
  第20回日本遺伝子治療学会（JSGT)学術集会
- Place of Presentation
  Tokyo
- Year and Date
  2014-08-06 – 2014-08-08
- Data Source
  KAKENHI-PROJECT-26293328
[Presentation] Immune tolerance induction of canine X-linked muscular dystrophy with fetal rAAV-microdystrophin transduction.
- Author(s)
  Hayashita-Kinoh H, Okada H, Nitahara-Kasahara Y, Chiyo T, Yugeta N, Okada T, Takeda S
- Organizer
  The 20th Annual Meeting of Japan Society of Gene Therapy
- Place of Presentation
  東京
- Year and Date
  2014-08-06 – 2014-08-08
- Data Source
  KAKENHI-PROJECT-26430102
[Presentation] Engraftment of mesenchymeal stem cells is effectively associated by IL-10 in skeletall muscle.
- Author(s)
  Yuko Nitahara-Kasahara, Hiromi Hayashita-Kinoh, Nana Tsumita, Tomoko Chiyo, Hironori Okada, Shin’ichi Takeda, Takashi Okada.
- Organizer
  The 20th Annual Meeting of Japan Society of Gene Therapy
- Place of Presentation
  Tokyo
- Year and Date
  2014-08-06 – 2014-08-08
- Data Source
  KAKENHI-PROJECT-24659265
[Presentation] Skeletal Muscle Engraftment of Mesenchymal Stromal Cells Is Augmented By IL-10
- Author(s)
  Nitahara-Kasahara Y, Hayashita-Kinoh H, Chiyo T, Okada H, Takeda S, Okada T
- Organizer
  American society of gene & cell therapy 17th Annual meeting
- Place of Presentation
  Washington DC, USA
- Year and Date
  2014-05-21 – 2014-05-24
- Data Source
  KAKENHI-PROJECT-26430102
[Presentation] Induction of Local OPMD Histopathology in Common Marmoset By rAAV1 and 8-Mediated Transduction
- Author(s)
  Okada H, Ishibashi H, Hayashita-Kinoh H, Chiyo T, Masuda C, Nitahara-Kasahara Y, Takeda S, Okada T
- Organizer
  American society of gene & cell therapy 17th Annual meeting
- Place of Presentation
  Washington DC, USA
- Year and Date
  2014-05-21 – 2014-05-24
- Data Source
  KAKENHI-PROJECT-26430102
[Presentation] Immune Tolerance Induction in Canine X-Linked Muscular Dystrophy With rAAV9-Microdystrophin Transduction
- Author(s)
  Hayashita-Kinoh H, Nitahara-Kasahara Y, Okada H, Chiyo T, Yugeta N, Okada T, Takeda S
- Organizer
  American society of gene & cell therapy 17th Annual meeting
- Place of Presentation
  Washington DC, USA
- Year and Date
  2014-05-21 – 2014-05-24
- Data Source
  KAKENHI-PROJECT-26430102
[Presentation] Engraftment of mesenchymal stromal cells is effectively associated by IL-10 in skeletal muscle.
- Author(s)
  Nitahara-Kasahara Y, Hayashita-Kinoh H, Tsumita N, Chiyo T, Okada H, Takeda S, Okada T
- Organizer
  The 20th Annual Meeting of Japan Society of Gene Therapy
- Place of Presentation
  東京
- Year and Date
  2014-08-06 – 2014-08-08
- Data Source
  KAKENHI-PROJECT-26430102
[Presentation] Immune tolerance induction in Canine X-Linked Muscular Dystrophy with rAAV9-Microdystrophin Transduction.
- Author(s)
  Hiromi Hayashita-Kinoh, Yuko Nitahara-Kasahara, Hironori Okada, Tomoko Chiyo, Naoko Yugeta, Takashi Okada, Shin’ichi Takeda.
- Organizer
  American Society of Gene and Cell Therapy 17th Annual Meeting
- Place of Presentation
  Washington, DC
- Year and Date
  2014-05-21 – 2014-05-24
- Data Source
  KAKENHI-PROJECT-24659265
[Presentation] IL10強制発現による機能強化型MSCsの作製と生存解析
- Author(s)
  笠原優子, 喜納裕美, 千代智子, 岡田浩典, 武田伸一, 岡田尚巳
- Organizer
  第35回日本炎症・再生医学会
- Place of Presentation
  沖縄
- Year and Date
  2014-07-01 – 2014-07-05
- Data Source
  KAKENHI-PROJECT-24659265
[Presentation] ラット一過性脳虚血モデルにおける歯髄幹細胞移植による脳保護効果の検討
- Author(s)
  仁藤智香子、中島壯崇、上田雅之、稲葉俊東、斎藤萌子、西山康弘、須田智、中村有希、今川究、立花克彦、岡田尚巳、木村和美
- Organizer
  第40回日本脳卒中学会総会
- Place of Presentation
  広島
- Year and Date
  2015-03-26 – 2015-03-29
- Data Source
  KAKENHI-PROJECT-26293328

1. OZAWA Keiya (30137707)

# of Collaborated Projects: 5 results

# of Collaborated Products: 17 results
2. MIZUKAMI Horoaki (20311938)

# of Collaborated Projects: 3 results

# of Collaborated Products: 13 results
3. URABE Masashi (40213516)

# of Collaborated Projects: 3 results

# of Collaborated Products: 7 results
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# of Collaborated Projects: 3 results

# of Collaborated Products: 23 results
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# of Collaborated Projects: 3 results

# of Collaborated Products: 110 results
6. KASAHARA Yuko (90391911)

# of Collaborated Projects: 3 results

# of Collaborated Products: 21 results
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# of Collaborated Products: 2 results
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# of Collaborated Products: 6 results
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# of Collaborated Products: 0 results
11. NAKAMURA Shinichiro (50307980)

# of Collaborated Projects: 1 results

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12. OKADA Takashi (00326823)

# of Collaborated Projects: 1 results

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13. NISHIMURA Masaki (40322739)

# of Collaborated Projects: 1 results

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14. MATSUO Akinori (20324585)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
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# of Collaborated Projects: 1 results

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16. Saito Takashi (40625969)

# of Collaborated Projects: 1 results

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17. KUME Akihiro (10264293)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. HANAZONO Yutaka (70251246)

# of Collaborated Projects: 1 results

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19. NAGAI Mutsumi (10265259)

# of Collaborated Projects: 1 results

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20. TAJIMA Toshihiro (50333597)

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21. ARIGA Tadashi (60322806)

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22. TAKEDA Shinichi (90171644)

# of Collaborated Projects: 1 results

# of Collaborated Products: 21 results
23. Kosho Tomoki (90276311)

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24. 間野博行 (90240704)

# of Collaborated Projects: 1 results

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# of Collaborated Projects: 1 results

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27. 野村義宏 (10228372)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
28. 岳鳳鳴 (20532865)

# of Collaborated Projects: 1 results

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29. 松本健一 (30202328)

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33. 吉沢隆浩 (40713392)

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34. 渡邉敬文 (50598216)

# of Collaborated Projects: 1 results

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35. 高橋淳 (60345741)

# of Collaborated Projects: 1 results

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36. 宮田真路 (60533792)

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37. 山田修平 (70240017)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
38. 高野亨子 (70392420)

# of Collaborated Projects: 1 results

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39. 山口智美 (90802835)

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41. 松坂恭成 (60420949)

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42. 恒川雄二 (80733352)

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46. 真下知士

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48. 戸田達史

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63. 石井亜紀子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
64. 永井義隆

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

OKADA TAKASHI 岡田 尚巳

OKADA Takashi 岡田 尚巳

岡田 尚已 オカダ タカシ

OKADA Tadashi 岡田 尚史

Research Projects

Research Products

Co-Researchers

アデノ随伴ウイルスベクター基盤技術開発と脳神経疾患に対する遺伝子細胞療法Principal Investigator

Principal Investigator

Project Period (FY)

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Review Section

Research Institution

アデノ随伴ウイルスベクター基盤技術開発と脳神経疾患に対する遺伝子細胞療法Principal Investigator

Principal Investigator

Project Period (FY)

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Principal Investigator

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Review Section

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LATmiRNAPrincipal Investigator

Principal Investigator

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AAV vector-mediated cell and gene therapy for neuronal diseasePrincipal Investigator

Principal Investigator

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Principal Investigator

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Principal Investigator

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Gene correction therapy by homologous recombinationPrincipal Investigator

Principal Investigator

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Principal Investigator

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Principal Investigator

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AAV vector-mediated cell and gene therapy for neuronal diseasesPrincipal Investigator

Principal Investigator

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Principal Investigator

Project Period (FY)

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Research Institution

AAV vector-mediated cell and gene therapy for neuronal diseasesPrincipal Investigator

Principal Investigator

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Research Field

Research Institution

糖鎖情報を利用したがん幹細胞マーカーの探索と腫瘍標的システムPrincipal Investigator

OKADA TAKASHI 岡田尚巳

OKADA Takashi 岡田尚巳

岡田尚已オカダタカシ

OKADA Tadashi 岡田尚史

[Book] 「筋ジストロフィー症」遺伝子治療開発研究ハンドブック　第2版2023