Takimoto Aki 滝本晶

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TAKIMOTO Aki 滝本晶

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Researcher Number	00378902
Other IDs
Affiliation (Current)	2025: 広島大学, 医系科学研究科(医), 研究員
Affiliation (based on the past Project Information) *help	2025: 広島大学, 医系科学研究科(医), 研究員 2017 – 2018: 京都大学, ウイルス・再生医科学研究所, 研究員 2012 – 2016: 京都大学, 健康長寿社会の総合医療開発ユニット, 特定助教 2015: 京都大学, 健康長寿社会の総合医療開発ユニット, 助教 2014 – 2015: 京都大学, 学内共同利用施設等, 助教
Review Section/Research Field	Principal Investigator Orthopaedic surgery / Basic Section 56020:Orthopedics-related Except Principal Investigator Functional basic dentistry / Orthodontics/Pediatric dentistry
Keywords	Principal Investigator 転写因子 / 椎間板 / 細胞・組織 / アグリカン / 転写調節 / 細胞外基質 / 軟骨形成 / 椎間板形成 / 軟骨 / 組織形成 … More / 転写制御 / Scleraxis / コラーゲン / 靭帯 / 腱 / コラーゲン線維形成 / コラーゲン線維 / 腱・靭帯 … More Except Principal Investigator 発生･分化 / 顎関節 / 靱帯 / ゲノム編集 / 遺伝子改変動物 / 硬組織 / 靭帯 / 腱 / 発生・分化 / トランスジェニックマウス / Scleraxis / 歯根膜 / メカニカルストレス / 歯学 Less

椎間板幹・前駆細胞におけるmiR-23による恒常性維持機構の解明Principal Investigator
- Principal Investigator
  
  滝本晶
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Hiroshima University
Analysis of molecular mechanisms underlying the intervertebral disc formation and homeostasis regulated by Pax1Principal Investigator
- Principal Investigator
  
  Takimoto Aki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Kyoto University
Mechanisms underlying formation of tissue domains integrating the skeletal components
- Principal Investigator
  
  Shukunami Chisa
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Hiroshima University
Regulation of vertebral column development by Pax1Principal Investigator
- Principal Investigator
  
  Takimoto Aki
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Kyoto University
Scleraxis-mediated regulation of mechanical responses in the periodontal ligament
- Principal Investigator
  
  SHUKUNAMI Chisa
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Orthodontics/Pediatric dentistry
- Research Institution
  Hiroshima University
The functional roles of collagen fibrillogenesis in tendons and ligaments during establishment of the musculoskeletal systemPrincipal Investigator
- Principal Investigator
  
  TAKIMOTO Aki
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Kyoto University

All 2019 2017 2016 2015 2014 2013 2012 Other

All Journal Article Presentation

[Journal Article] Differential transactivation of the upstream aggrecan enhancer regulated by PAX1/9 depends on SOX9-driven transactivation2019
- Author(s)
  Aki Takimoto, Chikara Kokubu, Hitomi Watanabe, Tetsushi Sakuma, Takashi Yamamoto, Gen Kondoh, Yuji Hiraki, Chisa Shukunami
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 4605-4605
- DOI
  10.1038/s41598-019-40810-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02966, KAKENHI-PROJECT-16K10899
[Journal Article] Scleraxis is required for maturation of tissue domains for proper integration of the musculoskeletal system.2017
- Author(s)
  Yoshimoto Y, Takimoto A, Watanabe H, Hiraki Y, Kondoh G, Shukunami C.
- Journal Title
  
  Sci Rep
  
  Volume: 7 Issue: 1 Pages: 45010-45010
- DOI
  10.1038/srep45010
- NAID
  120005998026
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26293395, KAKENHI-PROJECT-15K21098
[Journal Article] 靱帯の形成と再生2016
- Author(s)
  吉本由紀，滝本晶，宿南知佐
- Journal Title
  
  Keynote RA
  
  Volume: 4 Pages: 20-25
- Data Source
  KAKENHI-PROJECT-26293395
[Journal Article] Functional Investigation of a Non-coding Variant Associated with Adolescent Idiopathic Scoliosis in Zebrafish: Elevated Expression of the Ladybird Homeobox Gene Causes Body Axis Deformation.2016
- Author(s)
  Guo, L., Yamashita, H., Kou, I., Takimoto, A., Meguro-Horike, M., Horike, S., Adachi, T., Ikegawa, S., Hiraki, Y., Shukunami, C.
- Journal Title
  
  Plos Genetics
  
  Volume: 12 Issue: 1 Pages: e1005802-e1005802
- DOI
  10.1371/journal.pgen.1005802
- NAID
  120005698038
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26460409, KAKENHI-PUBLICLY-15H01470, KAKENHI-PROJECT-25430167, KAKENHI-PROJECT-26293395
[Journal Article] Molecular characterization and function of tenomodulin, a marker of tendons and ligaments that integrate musculoskeletal components.2016
- Author(s)
  Shukunami C, Yoshimoto Y, Takimoto A, Yamashita H, Hiraki Y.
- Journal Title
  
  Japanese Dental Science Review
  
  Volume: 164 Issue: 4 Pages: 1-9
- DOI
  10.1016/j.jdsr.2016.04.003
- NAID
  50010101372
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26293395
[Journal Article] 腱・靱帯形成の制御2015
- Author(s)
  滝本晶、吉本由紀、山下寛、宿南知佐
- Journal Title
  
  整形・災害外科
  
  Volume: 58 Pages: 1373-1379
- Data Source
  KAKENHI-PROJECT-26293395
[Journal Article] Scleraxis and osterix antagonistically regulate tensile force-responsive remodeling of the periodontal ligament and alveolar bone.2015
- Author(s)
  Takimoto A., Kawatsu M., Yoshimoto Y., Kawamoto T., Seiryu M., Takano-Yamamoto T., Hiraki Y., Shukunami C.
- Journal Title
  
  Development.
  
  Volume: 142(4) Issue: 4 Pages: 787-796
- DOI
  10.1242/dev.116228
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24593076, KAKENHI-PROJECT-24792271, KAKENHI-PROJECT-25670871, KAKENHI-PROJECT-25893020, KAKENHI-PROJECT-26293395, KAKENHI-PROJECT-26893164, KAKENHI-PROJECT-15K11336, KAKENHI-PROJECT-15H05048
[Journal Article] Generation and characterization of ScxCre transgenic mice2013
- Author(s)
  Sugimoto Y, Takimoto A, Hiraki Y, Shukunami C
- Journal Title
  
  Genesis
  
  Volume: 51(4) Pages: 275-283
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24791540
[Journal Article] Generation and characterization of ScxCre transgenic mice.2013
- Author(s)
  Y. Sugimoto, A. Takimoto, Y. Hiraki, C. Shukunami
- Journal Title
  
  Genesis.
  
  Volume: 51 Issue: 4 Pages: 275-283
- DOI
  10.1002/dvg.22372
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390289, KAKENHI-PROJECT-23659718, KAKENHI-PROJECT-24791540
[Presentation] 転写因子Pax1/9によるAggrecanの発現制御と椎間板組織における役割2019
- Author(s)
  滝本　晶、宿南　知佐
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-16K10899
[Presentation] Pax1/9による椎間板ECMの発現制御と恒常性維持2017
- Author(s)
  滝本　晶
- Organizer
  第18回運動器科学研究会
- Data Source
  KAKENHI-PROJECT-16K10899
[Presentation] 筋/骨格系を連結する組織におけるScleraxisの機能解析2016
- Author(s)
  吉本由紀、滝本晶、佐久間哲史、渡邊仁美、近藤　玄、山本　卓、開　祐司、宿南知佐
- Organizer
  日本ゲノム編集学会第１回大会
- Place of Presentation
  広島市
- Year and Date
  2016-08-06
- Invited
- Data Source
  KAKENHI-PROJECT-26293395
[Presentation] 筋・骨格系を連結する腱・靱帯の形成におけるScleraxisの役割2016
- Author(s)
  吉本　由紀、滝本　晶、渡邊　仁美、近藤　玄、開　祐司、宿南　知佐
- Organizer
  第４回若手による骨格筋細胞研究会
- Place of Presentation
  名古屋市
- Year and Date
  2016-11-15
- Data Source
  KAKENHI-PROJECT-26293395
[Presentation] Pax1とSox9による軟骨細胞の分化制御と脊柱の組織構築2015
- Author(s)
  滝本　晶、開　祐司、宿南　知佐
- Organizer
  第33回日本骨代謝学会学術集会
- Place of Presentation
  東京都新宿区、京王プラザホテル
- Year and Date
  2015-07-23
- Invited
- Data Source
  KAKENHI-PROJECT-26293395
[Presentation] Scxによる腱・靱帯付着部の形成の制御2015
- Author(s)
  吉本由紀、滝本晶、開祐司、宿南　知佐
- Organizer
  第33回日本骨代謝学会学術集会
- Place of Presentation
  東京都新宿区、京王プラザホテル
- Year and Date
  2015-07-25
- Invited
- Data Source
  KAKENHI-PROJECT-26293395
[Presentation] Pax1とSox9による軟骨細胞の分化制御と脊柱の組織構築2015
- Author(s)
  滝本晶、開祐司、宿南知佐
- Organizer
  第33回日本骨代謝学会学術集会
- Place of Presentation
  京王プラザホテル
- Year and Date
  2015-07-23
- Invited
- Data Source
  KAKENHI-PROJECT-26861186
[Presentation] 腱・靭帯と骨格の付着部を形成する細胞の分化と系譜解析2014
- Author(s)
  滝本晶，吉本由紀，秋山治彦，開祐司，宿南知佐
- Organizer
  第15回運動器科学研究会
- Place of Presentation
  東京都港区、ベルサール三田
- Year and Date
  2014-09-05
- Data Source
  KAKENHI-PROJECT-26293395
[Presentation] Establishment of an in vivo model for analysis of periodontal ligament formation2014
- Author(s)
  Yuki Sugimoto, Aki Takimoto, Yuji Hiraki, Chisa Shukunami
- Organizer
  第47回広島大学歯学会総会
- Place of Presentation
  広島市広島大学歯学部大講義室
- Year and Date
  2014-06-21
- Data Source
  KAKENHI-PROJECT-25670871
[Presentation] 歯根膜におけるScleraxisの発現とその制御2012
- Author(s)
  滝本晶, 宿南知佐, 川津正慶, 清流正弘, 山本照子, 開祐司
- Organizer
  第30回日本骨代謝学会学術集会
- Place of Presentation
  東京（京王プラザホテル）
- Invited
- Data Source
  KAKENHI-PROJECT-24791540
[Presentation] 矯正的歯の移動モデルを用いた歯根膜におけるScleraxisの機能解析2012
- Author(s)
  川津正慶, 宿南知佐, 滝本晶, 岩崎将也, 清流正弘, 池田悦子, 山本照子
- Organizer
  第71回日本矯正歯科学会
- Place of Presentation
  盛岡
- Data Source
  KAKENHI-PROJECT-24791540
[Presentation] 歯根膜におけるScleraxisの発現とその制御2012
- Author(s)
  滝本晶, 宿南知佐, 川津正慶, 清流正弘, 山本照子, 開祐司
- Organizer
  第30回日本骨代謝学会学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24791540
[Presentation] 矯正的歯の移動モデルを用いた歯根膜におけるScleraxisの機能解析2012
- Author(s)
  川津正慶, 宿南知佐, 滝本晶, 岩崎将也, 清流正弘, 池田悦子, 山本照子
- Organizer
  第71回日本矯正歯科学会
- Place of Presentation
  岩手
- Data Source
  KAKENHI-PROJECT-24791540
[Presentation] 歯根膜細胞における伸展刺激に応答したScleraxis発現調節メカニズムの解析
- Author(s)
  川津正慶，岩崎将也，清流正弘，池田悦子，滝本晶，宿南知佐，山本照子
- Organizer
  第72回日本矯正歯科学会大会
- Place of Presentation
  長野
- Data Source
  KAKENHI-PROJECT-25670871
[Presentation] 椎間板形成におけるPax1の役割
- Author(s)
  滝本　晶、開　祐司、宿南　知佐
- Organizer
  第32回日本骨代謝学会学術集会
- Place of Presentation
  大阪国際会議場
- Year and Date
  2014-07-24 – 2014-07-26
- Data Source
  KAKENHI-PROJECT-26861186

1. SHUKUNAMI Chisa (60303905)

# of Collaborated Projects: 3 results

# of Collaborated Products: 14 results
2. YAMAMOTO Teruko (00127250)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
3. YOSHIMOTO Yuki (40735304)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. 秋山治彦 (60402830)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. GERD SCHERER

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. RALF KIST

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. HORIKE Shinichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. SEIRYU Masahiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. SUGIMOTO Yuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 目黒牧子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Takimoto Aki 滝本 晶

TAKIMOTO Aki 滝本 晶

Research Projects

Research Products

Co-Researchers

椎間板幹・前駆細胞におけるmiR-23による恒常性維持機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of molecular mechanisms underlying the intervertebral disc formation and homeostasis regulated by Pax1Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mechanisms underlying formation of tissue domains integrating the skeletal components

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regulation of vertebral column development by Pax1Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Scleraxis-mediated regulation of mechanical responses in the periodontal ligament

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The functional roles of collagen fibrillogenesis in tendons and ligaments during establishment of the musculoskeletal systemPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Differential transactivation of the upstream aggrecan enhancer regulated by PAX1/9 depends on SOX9-driven transactivation2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Scleraxis is required for maturation of tissue domains for proper integration of the musculoskeletal system.2017

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] 靱帯の形成と再生2016

Author(s)

Journal Title

Data Source

[Journal Article] Functional Investigation of a Non-coding Variant Associated with Adolescent Idiopathic Scoliosis in Zebrafish: Elevated Expression of the Ladybird Homeobox Gene Causes Body Axis Deformation.2016

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Molecular characterization and function of tenomodulin, a marker of tendons and ligaments that integrate musculoskeletal components.2016

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] 腱・靱帯形成の制御2015

Author(s)

Journal Title

Data Source

[Journal Article] Scleraxis and osterix antagonistically regulate tensile force-responsive remodeling of the periodontal ligament and alveolar bone.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Generation and characterization of ScxCre transgenic mice2013

Author(s)

Journal Title

Takimoto Aki 滝本晶

TAKIMOTO Aki 滝本晶