Doi Hisashi 土居久志

… Alternative Names

DOI Hisashi 土居久志

Less

Researcher Number	00421818
Other IDs	https://orcid.org/0000-0001-9778-5841
Affiliation (Current)	2025: 大阪公立大学, 研究推進機構 , 特任教授
Affiliation (based on the past Project Information) *help	2024: 大阪公立大学, 研究推進機構, 特任教授 2020 – 2022: 国立研究開発法人理化学研究所, 生命機能科学研究センター, チームリーダー 2017: 国立研究開発法人理化学研究所, 神戸事業所ライフサイエンス技術基盤研究センター, チームリーダー 2015: 国立研究開発法人理化学研究所, その他部局等, その他 2015: 国立研究開発法人理化学研究所, ライフサイエンス技術基盤研究センター, チームリーダー … More 2014 – 2015: 理化学研究所, ライフサイエンス技術基盤研究センター, チームリーダー 2013 – 2015: 独立行政法人理化学研究所, ライフサイエンス技術基盤研究センター, チームリーダー 2012: 独立行政法人理化学研究所, 分子イメージング標識化学研究チーム, チームリーダー 2010: 理化学研究所・分子イメージング科学研究センター, チームリーダー 2009 – 2010: The Institute of Physical and Chemical Research, 分子イメージング標識化学研究チーム, チームリーダー 2008: The Institute of Physical and Chemical Research, 創薬合成化学研究ユニット, ユニットリーダー 2007: The Institute of Physical and Chemical Research, 分子プローブ設計創薬研究チーム, 副チームリーダー Less
Review Section/Research Field	Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / Synthetic chemistry / Chemical pharmacy Except Principal Investigator Living organism molecular science / Medium-sized Section 90:Biomedical engineering and related fields / Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related / Basic Section 59040:Nutrition science and health science-related / Radiation science / Biomolecular chemistry / Biomedical engineering/Biomaterial science and engineering
Keywords	Principal Investigator 合成化学 / 診断・治療 / ドラッグデリバリー / 癌診断と治療 / セラノティクス / DDS製剤 / 小分子輸送タンパク質 / 低分子抗癌剤 / 18F-標識PETプローブ / SN-38誘導体 … More / 診断と治療 / 薬物送達 / 分子イメージング / 抗がん剤 / 超希薄濃度 / セラノスティクス / 薬物輸送 / 低分子輸送タンパク質 / プロスタグランジンD合成酵素 / 分子設計と化学合成 / 抗癌剤 / 18F-標識 / 遠隔操作合成装置 / PET標識化学 / PET分子イメージング / マイクロスケール反応器 / 有機金属化学 / 高速化学反応 / 常圧化学反応 / [11C]二酸化炭素 / [11C]カルボキシル化 / PET化学 / ^18F放射核 / 乳酸 / アミノ酸 / GABA / 生物活性有機化合物 / 標識化学 / ^<18>F放射核 / PET / 放射線 / 脳神経 / 生理活性 / 生体分子 … More Except Principal Investigator PETイメージング / 受容体 / アクロメリン酸 / 分子プローブ / アロディニア / ストレス / パラ水素誘起偏極 / 代謝 / 認知機能障害 / 超偏極13C MRI / 肝炎 / 放射標識 / ｍRNA / 脂質ナノ粒子 / セロトニン神経 / 脳内炎症 / 末梢感染 / 倦怠感 / 画像医学 / インテグリン / 血管構築 / Response / Interim / 高速クロスカップリング反応 / ギンセノシド / ギンゴライド / 認知症(脳機能)改善漢方薬成分 / クロスメタセシス反応 / 高速クロスカップリング / グルコース / 分子イメージング / PET分子プローブ / クロスメタセシス / 高速メチル化 / グルコーストランスポーター / 認知症改善薬ギンゴライド＆ギンセノシド / 11C,18F-標識化 / PETプローブ / 糖輸送体 / 脳移行性 / ギンゴライド＆ジンセノサイド / PET分子イメージング / 11C標識 / リポカリン蛋白質 / リポカリンタンパク質 / ナノカプセル / 生体内輸送タンパク質 / 薬物送達システム / 生体内輸送蛋白質 / 癌指向性 / タンパク質ナノカプセル / 難水溶性薬剤 / DDS / カイニン酸 / グルタミン酸受容体 / カイノイド / 神経障害性疼痛 / 陽電子放射断層画像撮影法 / カイニン酸受容体 / PET / 陽電子放射画像撮影法 / 神経障害性痙痛 Less

末梢感染による脳内局所炎症が倦怠感を惹起する分子・神経基盤の解明
- Principal Investigator
  
  崔翼龍
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Hyogo Medical University
PETを用いた肝疾患病態におけるmRNA内封脂質ナノ粒子の動態―遺伝子発現相関研究
- Principal Investigator
  
  毛利浩太
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  Nagasaki University
超偏極13C脳代謝MRIによる末梢・全身性疾患に伴う認知機能障害の包括的理解
- Principal Investigator
  
  松元慎吾
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 90:Biomedical engineering and related fields
- Research Institution
  Hokkaido University
Development of SN-38 derivatives with antitumor activity toward theranosticsPrincipal Investigator
- Principal Investigator
  
  Doi Hisashi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Institute of Physical and Chemical Research
Construction of microcirculation and imaging evaluation method in intractable disease
- Principal Investigator
  
  TATEISHI Ukihide
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  Tokyo Medical and Dental University
Development of poorly water-soluble drug encapsulated protein nanocapsule possessing cancer directivity and application to DDS
- Principal Investigator
  
  Inui Takashi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Biomedical engineering/Biomaterial science and engineering
- Research Institution
  Osaka Prefecture University
Development of PET probes of neuroprotective molecular components in oriental medicines
- Principal Investigator
  
  SUZUKI Masaaki
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Biomolecular chemistry
- Research Institution
  National Center for Geriatrics and Gerontology
Design and synthesis of kainoid-type molecular probes for elucidation of the mechanism of allodynia induction
- Principal Investigator
  
  FURUTA Kyoji
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Living organism molecular science
- Research Institution
  Gifu University
Rh(I)-Mediated rapid [11C]carboxylation using [11C]CO2 and organoborane at atmospheric pressurePrincipal Investigator
- Principal Investigator
  
  DOI Hisashi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Synthetic chemistry
- Research Institution
  The Institute of Physical and Chemical Research
Synthesis of molecular probes for exploring the novel receptor involved in the allodynia induction
- Principal Investigator
  
  FURUTA Kyoji
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Living organism molecular science
- Research Institution
  Gifu University
Synthesis of ^<18>F-labeled GABA, amino acids, and lactic acids by using oxazoline precursorsPrincipal Investigator
- Principal Investigator
  
  DOI Hisashi
- Project Period (FY)
  2007 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  The Institute of Physical and Chemical Research

All 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 Other

All Journal Article Presentation Book Patent

[Book] 科学と工業(大阪工研協会会誌),85(4)(短寿命PET分子プローブの合成のための高速化学反応の開発)2011
- Author(s)
  土居久志
- Data Source
  KAKENHI-PROJECT-19790028
[Book] 臨床医とコメディカルのための最新クリニカルPET,"第15章2.PET分子プローブの開発研究とその進歩"2010
- Author(s)
  土居久志
- Publisher
  先端医療技術研究所
- Data Source
  KAKENHI-PROJECT-19790028
[Book] 創薬研究への分子イメージング応用,"第1章3.PET分子プローブの合成法"2010
- Author(s)
  土居久志
- Publisher
  メディカルドゥ
- Data Source
  KAKENHI-PROJECT-19790028
[Book] 遺伝子医学MOOK18号創薬研究への分子イメージング応用,"第1章3.PET分子プローブの合成法"2010
- Author(s)
  土居久志
- Publisher
  メディカルドゥ
- Data Source
  KAKENHI-PROJECT-19790028
[Journal Article] Detection of Cyclooxygenase-1 in Activated Microglia During Amyloid Plaque　Progression: PET Studies in Alzheimer's Disease Model Mice.2016
- Author(s)
  Miho Shukuri, Aya Mawatari, Masahiro Ohno, Masaaki Suzuki, Hisashi Doi, Yasuyoshi Watanabe, Hirotaka Onoe
- Journal Title
  
  Journal of Nuclear Medicine
  
  Volume: 57 Issue: 2 Pages: 291-296
- DOI
  10.2967/jnumed.115.166116
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09904, KAKENHI-PROJECT-25242070
[Journal Article] Synthesis of 11C-labeled capsaicin and its application for in vivo molecular imaging in rats by positron emission tomography.2015
- Author(s)
  Goto Miki, Mizuma Hiroshi, Wada Yasuhiro, Suzuki Masaaki, Watanabe Yasuhiro, Onoe Hirotaka, Doi Hisashi
- Journal Title
  
  Food and Nutrition Science
  
  Volume: 6 Issue: 02 Pages: 216-220
- DOI
  10.4236/fns.2015.62022
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25242070
[Journal Article] A novel [11C]-labeled thymidine analog, [11C]AZT, for tumor imaging by positron emission tomography2015
- Author(s)
  Tsuyoshi Tahara, Zhouen Zhang, Masahiro Ohno, Yukako Hirano, Nami Hasaka, Hisashi Doi, Masaaki Suzuki, and Hirotaka onoe
- Journal Title
  
  EJNMMI Res.
  
  Volume: 5 Issue: 1 Pages: 45-45
- DOI
  10.1186/s13550-015-0124-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25242070
[Journal Article] Synthesis of 11C-labeled thiamine and fursulthiamine for in vivo molecular imaging of vitamin B1 and its prodrug using positron emission tomography2015
- Author(s)
  Hisashi Doi, Aya Mawatari, Masakatsu Kanazawa, Satoshi Nozaki, Yukihiro Nomura, Takahito Kitayoshi, Kouji Akimoto, Masaaki Suzuki, Shinji Ninomiya, Yasuyoshi Watanabe
- Journal Title
  
  J. Org. Chem.
  
  Volume: 80 Issue: 12 Pages: 6250-6258
- DOI
  10.1021/acs.joc.5b00685
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25242070
[Journal Article] Quantitative Evaluation of the Improvement in the Pharmacokinetics of a Nucleic Acid Drug Delivery System by Dynamic PET Imaging with 18F-incorporated Oligodeoxynucleotides2014
- Author(s)
  H. Mukai, D. Ozaki, Y. Cui, T. Kuboyama, H. Yamato-Nagata, K. Onoe, M. Takahashi, Y. Wada, T. Imanishi, T. Kodama, S. Obika,* M Suzuki, H. Doi, Y. Watanabe
- Journal Title
  
  J. Controlled Release
  
  Volume: 180 Pages: 92-99
- DOI
  10.1016/j.jconrel.2014.02.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249007, KAKENHI-PROJECT-25242070
[Journal Article] [11C]Cetrozole: an improved C-[11C]methylated PET probe for aromatase imaging in the brain.2014
- Author(s)
  Kayo Takahashi, Takamitsu Hosoya, Kayo Onoe, Hisashi, Doi, Hiroko Nagata, Toshiyuki Hiramatsu, Xiao-Le Li, Yumiko Watanabe, Yasuhiro Wada, Tadayuki Takashima, Masaaki Suzuki, Hirotaka Onoe, Yasuyoshi, Watanabe
- Journal Title
  
  J. Nucl. Med.
  
  Volume: 55 Issue: 5 Pages: 852-857
- DOI
  10.2967/jnumed.113.131474
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25242070, KAKENHI-PROJECT-25830024
[Journal Article] Efficient syntheses of [11C]zidovudine and its analogues by convenient one-pot palladium(0)-copper(I)co-mediated rapid C-[11C]methylation.2014
- Author(s)
  Zhouen Zhang, Hisashi Doi, Hiroko Koyama, Yasuyoshi Watanabe, Masaaki Suzuki
- Journal Title
  
  J. Label. Compd. Radiopharm.
  
  Volume: 57 Issue: 8 Pages: 540-549
- DOI
  10.1002/jlcr.3213
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25242070, KAKENHI-PROJECT-25460147
[Journal Article] Pd(0)-mediated rapid cross-coupling reactions, the rapid C-[11C]methylations, revolutionally advancing the syntheses of short-lived PET molecular probes2014
- Author(s)
  Masaaki Suzuki, Hisashi Doi, Hiroko Koyama, Zhang Zhouen, Takamitsu Hosoya, Hirotaka Onoe, Yasuyoshi Watanabe
- Journal Title
  
  Chem. Rec.
  
  Volume: 14 Issue: 3 Pages: 516-541
- DOI
  10.1002/tcr.201400002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25242070, KAKENHI-PROJECT-25460147
[Journal Article] 11C-labeling of the C(1)-C(10) dihydroxy acid moiety for the study on the synthesis of kulokekahilide-2 PET tracer.2014
- Author(s)
  Chunguang Han, Hisashi Doi, Junji Kimura, Yoichi Nakao, and Masaaki Suzuki
- Journal Title
  
  Int. J. Org. Chem.
  
  Volume: 4 Issue: 04 Pages: 269-277
- DOI
  10.4236/ijoc.2014.44029
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25242070
[Journal Article] Synthesis of 11C-labeled retinoic acid, [11C]ATRA, via an alkenylboron precursor by Pd(0)-mediated rapid C-[11C]methylation2014
- Author(s)
  Masaaki Suzuki, Misato Takashima-Hirano, Hideki Ishii, Chika Watanabe, Kengo Sumi, Hiroko Koyama, Hisashi Doi,
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 24 Issue: 15 Pages: 3622-3625
- DOI
  10.1016/j.bmcl.2014.05.041
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590156, KAKENHI-PROJECT-25242070, KAKENHI-PROJECT-25460147
[Journal Article] Evaluation of TlOH Effect for Pd0-Mediated Cross-Coupling of Methyl Iodide and Excess Boronic Acid Ester toward Fabrication of [11C]CH3-Incorporated PET Tracer.2013
- Author(s)
  Hiroko Koyama, Hisashi Doi, Masaaki Suzuki
- Journal Title
  
  Int. J. Org. Chem.
  
  Volume: 3 Issue: 03 Pages: 220-223
- DOI
  10.4236/ijoc.2013.33030
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25242070, KAKENHI-PROJECT-25460147
[Journal Article] Pd0-Mediated Rapid Coupling of Methyl Iodide with Excess Amounts of Benzyl- and Cinnamylboronic Acid Esters: Efficient Method for Incorporation of Positron–Emitting 11C Radionuclide into Organic Frameworks by Coupling between Two sp3-Hybridized Carbons2013
- Author(s)
  Hiroko Koyama, Zhouen Zhang, Ryosuke Ijuin, Siqin, Jeongwan Son, Yuma Hatta, Masashi Ohta, Masahiro Wakao, Takamitsu Hosoya, Hisashi Doi, Masaaki Suzuki
- Journal Title
  
  RSC Advances
  
  Volume: 3 Issue: 24 Pages: 9391-9401
- DOI
  10.1039/c3ra40815a
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25242070, KAKENHI-PROJECT-25460147
[Journal Article] Dynamic Analysis of Fluid Distribution in the Gastrointestinal Tract in Rats: Positron Emission Tomography Imaging after Oral Administration of Nonabsorbable Marker, [(18)F]Deoxyfluoropoly(ethylene glycol)2013
- Author(s)
  Takashima T, Shingaki T, Katayama Y, Hayashinaka E, Wada Y, Kataoka M, Ozaki D, Doi H, Suzuki M, Ishida S, Hatanaka K, Sugiyama Y, Akai S, Oku N, Yamashita S, Watanabe Y
- Journal Title
  
  Mol. Pharmaceutics
  
  Volume: 10 Issue: 6 Pages: 2261-2269
- DOI
  10.1021/mp300469m
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659049, KAKENHI-PROJECT-25242070
[Journal Article] Synthesis of an 11C-Labeled Antiprion GN8 Derivative and Evaluation of Its Brain Uptake by Positron Emission Tomography2013
- Author(s)
  Tsutomu Kimura, Takeo Sako, Siqin, Junji Hosokawa-Muto, Yi Long Cui, Yasuhiro Wada, Yosky Kataoka, Hisashi Doi, Suehiro Sakaguchi, Masaaki Suzuki, Yasuyoshi Watanabe, Kazuo Kuwata
- Journal Title
  
  ChemMedChem
  
  Volume: 8(7) Issue: 7 Pages: 1035-1039
- DOI
  10.1002/cmdc.201300167
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23370068, KAKENHI-PROJECT-24570180, KAKENHI-PROJECT-24659574, KAKENHI-PROJECT-25242070, KAKENHI-PROJECT-25460399
[Journal Article] The action site of the synthetic kainoid (2S,3R,4R)-3-carboxymethyl-4-(4-methylp henylthio) pyrrolidine-2-carboxylic acid (PSPA-4), an analogue of Japanese mushroom poison acromelic acid, for allodynia (tactile pain)2012
- Author(s)
  Miyazaki S, Minami T, Mizuma H, Kanazawa, M, Doi H, Matsumura S, Lu J, Onoe H, Furuta K, Suzuki M and Ito S
- Journal Title
  
  Eur J Pharmacol
  
  Volume: (in press) Issue: 1-3 Pages: 120-127
- DOI
  10.1016/j.ejphar.2012.10.023
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390063, KAKENHI-PROJECT-22591753, KAKENHI-PROJECT-23659322, KAKENHI-PROJECT-24310154, KAKENHI-PROJECT-24590735, KAKENHI-PROJECT-24659294, KAKENHI-PROJECT-25462456
[Journal Article] Synthesis of an acromelic acid A analog-based <11>^C-labeled PET tracer for exploration of the site of action of acromelic acid A in allodynia induction.2011
- Author(s)
  M.Kanazawa, K.Furuta, H.Doi, T.Mori, T.Minami, S.Ito, M.Suzuki
- Journal Title
  
  Bioorg.Med.Chem.Lett. 21
  
  Pages: 2017-2020
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20310131
[Journal Article] Palladium(O)-Mediated Rapid Methylation and Fluoromethylation on Carbon Frameworks by Reacting Methyl and Fluoromethyl Iodide with Aryl and Alkenyl Boronic Acid Esters Useful for the Synthesis of C-^<11>CH_3- and C-^<18>FCH_2-Containing PET Tracers2009
- Author(s)
  Hisashi Doi
- Journal Title
  
  Chemistry-A European Journal 15
  
  Pages: 4165-4171
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790028
[Journal Article] Palladium(0)-Mediated Rapid Methylation and Fluoromethylation on Carbon Frameworks by Reacting Methyl and Fluoromethyl Iodide with Aryl and Alkenyl Boronic Acid Esters Useful for the Synthesis of [^<11>C]CH_3-C-and [^<18>F]FCH_2-C-Containing PET Tracers2009
- Author(s)
  Hisashi Doi, Ikuya Ban, Akihito Nonoyama, Kengo Sumi, Chunxiang Kuang, Takamitsu Hosoya, Hideo Tsukada, Masaaki Suzuki
- Journal Title
  
  Chem.Eur.J. 15
  
  Pages: 4165-4171
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790028
[Journal Article] Palladium(0)-Mediated Rapid Methylation and Fluoromethylation on Carbon Frameworks by Reacting Methyl and Fluoromethyl Iodide with Aryl and Alkenyl Boronic Acid Esters Useful for the Synthesis of [11C]CH3-C- and [18F]FCH2-C-Containing PET Tracers2009
- Author(s)
  Hisashi Doi, Ikuya Ban, Akihito Nonoyama, Kengo Sumi, Chunxiang Kuang, Takamitsu Hosoya, Hideo Tsukada, Masaaki Suzuki
- Journal Title
  
  Chem. Eur. J. 15
  
  Pages: 4165-4171
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790028
[Journal Article] Palladium(O)-Mediated Rapid Methylation and Fluoromethylation on Carbon Frameworks by Reacting Methyl and Fluoromethyl Iodide with Aryl andAlkenyl Boronic Acid Esters Useful for the Synthesis of C-^<11>CH_3- and C-^<18>FCH_2-Containing PET Tracers2009
- Author(s)
  土居久志
- Journal Title
  
  Chemistry - A European Journal (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790028
[Patent] 高速フルオロメチル化法及びそれを利用したPETトレーサーの製造方法2010
- Inventor(s)
  鈴木正昭、土居久志、、後藤美樹
- Industrial Property Rights Holder
  (独)理化学研究所
- Filing Date
  2010-12-03
- Data Source
  KAKENHI-PROJECT-19790028
[Patent] PET用標識化合物2009
- Inventor(s)
  渡辺恭良、尾上浩隆、高橋佳代、鈴木正昭、土居久志、細谷孝充
- Industrial Property Rights Holder
  独立行政法人理化学研究所
- Industrial Property Number
  2009-159129
- Filing Date
  2009-07-03
- Data Source
  KAKENHI-PROJECT-19790028
[Patent] アイソトープ標識化合物及びアイソトープ標識化合物前駆体2009
- Inventor(s)
  桑田一夫、木村力、武藤淳二、古山浩子、鈴木正昭、渡辺恭良、土居久志、佐古健生
- Industrial Property Rights Holder
  独立行政法人理化学研究所、国立岐阜大学
- Industrial Property Number
  2009-218247
- Filing Date
  2009-09-21
- Data Source
  KAKENHI-PROJECT-19790028
[Patent] 高速フルオロメチル化法及びそれを利用したPETトレーサーの製造方法2009
- Inventor(s)
  鈴木正昭、土居久志、後藤美樹
- Industrial Property Rights Holder
  独立行政法人理化学研究所
- Industrial Property Number
  2009-277028
- Filing Date
  2009-12-04
- Data Source
  KAKENHI-PROJECT-19790028
[Patent] アイソトープ標識2-アリールプロピオン酸類及びその製造方法、並びに陽電子放射断層画像撮像用分子プローブ及びそれを用いたシクロオキシゲナーゼのイメージング方法2009
- Inventor(s)
  高島好聖、宿里充穂、後藤美樹、土居久志、尾上浩隆、鈴木正昭、渡辺恭良
- Industrial Property Rights Holder
  独立行政法人理化学研究所
- Industrial Property Number
  2009-181122
- Filing Date
  2009-08-03
- Data Source
  KAKENHI-PROJECT-19790028
[Patent] ^<18>F標識アジド化合物、^<18>F標識化用試薬及びそれを用いたアルキン化合物の^<18>F標識方法2009
- Inventor(s)
  渡辺恭良、鈴木正昭、土居久志、窪山剛之、小比賀聡、今西武
- Industrial Property Rights Holder
  独立行政法人理化学研究所、国立大阪大学
- Industrial Property Number
  2009-118505
- Filing Date
  2009-05-15
- Data Source
  KAKENHI-PROJECT-19790028
[Patent] 高速フルオロメチル化法及びそれを利用したpetトレーサーの製造方法2009
- Inventor(s)
  鈴木正昭、土居久志、後藤美樹
- Industrial Property Rights Holder
  (独)理化学研究所
- Filing Date
  2009-12-04
- Data Source
  KAKENHI-PROJECT-19790028
[Presentation] Rh(I)-mediated rapid [11C]carboxylation using [11C]CO2 and organoborate at atmospheric pressure2015
- Author(s)
  Miki Goto, Sachi Kurai, Ryo Yamamoto, Tomozumi Kanamitsu, Masaaki Suzuki, Yasuyohi Watanabe, Hisashi Doi
- Organizer
  The International Chemical Congress of Pacific Basin Societies 2015
- Place of Presentation
  Honolulu, Hawaii, USA
- Year and Date
  2015-12-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25242070
[Presentation] Evaluation of TlOH Effects for Pd0-Mediated Cross-Coupling of Methyl Iodide and Excess Boronic Acid Esters toward 11C-Incorporated PET Tracer Synthesis, Research area (10) Bench to Bedside2015
- Author(s)
  Hiroko Koyama, Hisashi Doi, Masaaki Suzuki
- Organizer
  The International Chemical Congress of Pacific Basin Societies 2015
- Place of Presentation
  Honolulu, Hawaii, USA
- Year and Date
  2015-12-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25242070
[Presentation] 11C-labeling of the C(1)-C(10) dihydroxy acid moiety for the study on the synthesis of kulokekahilide-2 PET tracer2015
- Author(s)
  Chunguang Han, Hisashi Doi, Jyunji Kimura, Yoichi Nakao, Masaaki Suzuki
- Organizer
  The International Chemical Congress of Pacific Basin Societies 2015
- Place of Presentation
  Honolulu, Hawaii, USA
- Year and Date
  2015-12-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25242070
[Presentation] 脳内aromataseとヒトの性格・気質との関連―PET 研究2014
- Author(s)
  高橋佳代、細谷孝充、高島忠之、田中雅彰、石井聰、中富康仁、田沢周作、高橋和弘、土居久志、和田康弘、鈴木正昭、尾上浩隆、渡辺恭良
- Organizer
  日本分子イメージング学会　第9回学会総会・学術集会
- Place of Presentation
  千里ライフサイエンスセンター
- Data Source
  KAKENHI-PROJECT-25242070
[Presentation] Imaging of cyclooxygenase-1 in activated microglia by PET with S-enantiomer of 11C-ketoprofen-methyl ester2013
- Author(s)
  Miho Shukuri, Aya Mawatari, Masahiro Ohno, Hisashi Doi, Masaaki Suzuki, Yasuyoshi Watanabe, Hirotaka Onoe
- Organizer
  EANM'13-Annual Congress of the European Association of Nuclear Medicine
- Place of Presentation
  France・Lyon
- Data Source
  KAKENHI-PROJECT-25242070
[Presentation] Application of C-11 Intermediates and Methodology: 11C-labeling methods by C-C bond formation using [11C]CH3I mediated by Pd0 catalysts2013
- Author(s)
  Hisashi Doi
- Organizer
  C-11 Workshop in pre-symposium in The 20th International Symposium on Radiopharmaceutical Sciences (ISRS 2013)
- Place of Presentation
  International Convention Center (ICC) Jeju, Jeju, Korea
- Invited
- Data Source
  KAKENHI-PROJECT-24550127
[Presentation] アクロメリン酸類縁体のPETプローブ化2013
- Author(s)
  小岩大智，金澤奨勝，宮崎信一郞，水間　広，土居久志，尾上浩隆，鈴木正昭，南　敏明，伊藤誠二，古田享史
- Organizer
  第44回中部化学関係学協会支部連合秋季大会
- Place of Presentation
  静岡大学
- Data Source
  KAKENHI-PROJECT-24310154
[Presentation] 「理研におけるPET標識化学の展開:11Cおよび18F-標識法の現状と将来展望」、分子イメージング研究シンポジウム2010-未来を拓く創薬・疾患診断研究-2010
- Author(s)
  土居久志
- Organizer
  Molecular Imaging 2010, The Future with Drug Discovery and PET Diagnosis
- Place of Presentation
  日経ビル3階日経ホール、東京
- Data Source
  KAKENHI-PROJECT-19790028
[Presentation] [^<18>F]FCH_2基含有PETトレーサーの新規合成法の開発;New Methodology of the Synthesis of [^<18>F]FCH_2-Incorporated PET Tracers2010
- Author(s)
  後藤美樹、土居久志、鈴木正昭
- Organizer
  日本ケミカルバイオロジー学会第5回年会
- Place of Presentation
  慶応義塾大学、横浜
- Data Source
  KAKENHI-PROJECT-19790028
[Presentation] 理研におけるPET標識化学の展開:^<11>Cおよび^<18>F-標識法の現状と将来展望2010
- Author(s)
  土居久志
- Organizer
  分子イメージング研究シンポジウム2010-未来を拓く創薬・疾患診断研究-,Molecular Imaging 2010, The Future with Drug Discovery and PET Diagnosis
- Place of Presentation
  日経ビル3階日経ホール、東京
- Data Source
  KAKENHI-PROJECT-19790028
[Presentation] 理研におけるPET標識化学の展開:^<11>Cおよび^<18>F-標識法の現状と将来展望2010
- Author(s)
  土居久志
- Organizer
  分子イメージング研究シンポジウム2010
- Place of Presentation
  日経ホール(東京)
- Year and Date
  2010-01-22
- Data Source
  KAKENHI-PROJECT-19790028
[Presentation] アロディニア誘発に関わる受容体探索のためのPETプローブの創製2010
- Author(s)
  金澤奨勝、森智子、土居久志、伊藤誠二、南敏明、鈴木正昭、古田享史
- Organizer
  日本化学会第90春季年会
- Place of Presentation
  大阪
- Year and Date
  2010-03-28
- Data Source
  KAKENHI-PROJECT-20310131
[Presentation] Pd^0-mediated rapid C-[^<18>F]fluoromethylation : Coupling reaction of an organoboron compound with a [^<18>F]fluoromethyl halide2010
- Author(s)
  H.Doi, M.Goto, M.Suzuki
- Organizer
  2010 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2010)
- Place of Presentation
  Hawaii, USA
- Year and Date
  2010-12-15
- Data Source
  KAKENHI-PROJECT-19790028
[Presentation] Pd^0-mediated rapid C-[^<18>F]fluoromethylation by the reaction of a [^<18>F]fluoromethyl halide and an organoboron compound2010
- Author(s)
  H.Doi, M.Goto, M.Suzuki
- Organizer
  15th European Symposium On Radiopharmacy And Radiopharmaceuticals, Abstract, Q.J.Nucl.Med.Mol.Imaging, 54, Suppl.1 to No.2, pp 18.19.
- Place of Presentation
  Edinburgh, Scotland (UK)
- Data Source
  KAKENHI-PROJECT-19790028
[Presentation] PETを活用した分子イメージング創薬化学の展開;Molecular imaging medicinal chemistry by PET in RIKEN CMIS2009
- Author(s)
  土居久志
- Organizer
  第7回糖鎖科学コンソーシアムシンポジウム～糖鎖研究と他領域との統合
- Place of Presentation
  千里ライフサイエンスセンター、大阪
- Data Source
  KAKENHI-PROJECT-19790028
[Presentation] PETプローブの一般的合成法の開発とPETケミカルバイオロジーへの展開;Development of General Synthetic Methodologies of PET Probes and Its Applications to PET Chemical Biology2009
- Author(s)
  土居久志、橋爪良信、畑中恵子、高島好聖、後藤美樹、長田浩子、斯琴、倉橋正浩、鈴木正昭
- Organizer
  日本ケミカルバイオロジー学会第4回年会
- Place of Presentation
  神戸市産業振興センター、神戸
- Data Source
  KAKENHI-PROJECT-19790028
[Presentation] PETプローブの一般的合成法の開発とPETケミカルバイオロジーへの展開2009
- Author(s)
  土居久志
- Organizer
  日本ケミカルバイオロジー学会第4回年会
- Place of Presentation
  神戸市産業振興センター(神戸)
- Year and Date
  2009-05-19
- Data Source
  KAKENHI-PROJECT-19790028
[Presentation] PETを活用した分子イメージング創薬化学の展開2009
- Author(s)
  土居久志
- Organizer
  第7回糖鎖科学コンソーシアムシンポジウム～糖鎖研究と他領域との統合
- Place of Presentation
  千里ライフサイエンスセンター(大阪)
- Year and Date
  2009-12-07
- Data Source
  KAKENHI-PROJECT-19790028
[Presentation] 新規^<11>C-標識反応の開発とPETプローブ化への応用2008
- Author(s)
  土居久志
- Organizer
  分子イメージング研究シンポジウム2008
- Place of Presentation
  神戸国際会議場
- Year and Date
  2008-11-14
- Data Source
  KAKENHI-PROJECT-19790028
[Presentation] Pd(0)-Mediated Rapid C-Methylations for the Synthesis of 11C-Incorporated PET Tracers2008
- Author(s)
  土居久志
- Organizer
  1st International Conference on Drug Design & Discovery
- Place of Presentation
  ドバイ世界貿易センター,UAE
- Year and Date
  2008-02-05
- Data Source
  KAKENHI-PROJECT-19790028
[Presentation] PETトレーサーの新合成法の開発と応用2007
- Author(s)
  土居久志
- Organizer
  第47回日本核医学会学術総会
- Place of Presentation
  仙台国際センター
- Year and Date
  2007-11-04
- Data Source
  KAKENHI-PROJECT-19790028
[Presentation] Rh触媒による[11C]二酸化炭素を用いた[11C]カルボン酸体の高速合成
- Author(s)
  後藤美樹、倉井佐知、鈴木正昭、土居久志
- Organizer
  第10回日本分子イメージング学会
- Place of Presentation
  タワーホール船橋（東京）
- Year and Date
  2015-05-20 – 2015-05-21
- Data Source
  KAKENHI-PROJECT-24550127
[Presentation] PETイメージング創薬の基盤となる標識化学技術：低分子、中分子、生体分子のPETプローブ化法
- Author(s)
  土居久志
- Organizer
  第32回メディシナルケミストリーシンポジム
- Place of Presentation
  神戸国際会議場（神戸）
- Year and Date
  2014-11-26 – 2014-11-28
- Invited
- Data Source
  KAKENHI-PROJECT-24550127

1. FURUTA Kyoji (40173538)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
2. MINAMI Toshiaki (00257841)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
3. Inui Takashi (80352912)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 喜田達也 (70641968)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. GOTO Miki (60565779)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. ISHIBASHI Osamu (70293214)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. KATAOKA Yosuke (40291033)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. NAKAJIMA Hidemitsu (30405360)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. SUZUKI Masaaki (90093046)

# of Collaborated Projects: 1 results

# of Collaborated Products: 14 results
10. ISHII Hideki (80425610)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
11. KOYAMA Hiroko (50402160)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
12. UMEMURA Kazuo (40232912)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. TATEISHI Ukihide (20415524)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. KANO Daisuke (70392347)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 崔翼龍 (60312229)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 田原強 (20419708)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 根山広行 (70846609)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 戴毅 (20330441)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 毛利浩太 (30723697)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 向井英史 (60570885)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 松元慎吾 (90741041)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. KURAI Sachi

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
23. WADA Koichi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. YAGI Naoto

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. OGATA Aya

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. SHUKURI Miho

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. 兒玉哲也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. 小比賀聡

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. 奥直人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
30. 赤井周司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
31. 桑田一夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
32. 松村伸治

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
33. 伊藤誠二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Doi Hisashi 土居 久志

DOI Hisashi 土居 久志

Research Projects

Research Products

Co-Researchers

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of SN-38 derivatives with antitumor activity toward theranosticsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Rh(I)-Mediated rapid [11C]carboxylation using [11C]CO2 and organoborane at atmospheric pressurePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Synthesis of ^<18>F-labeled GABA, amino acids, and lactic acids by using oxazoline precursorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 科学と工業(大阪工研協会会誌),85(4)(短寿命PET分子プローブの合成のための高速化学反応の開発)2011

Author(s)

Data Source

[Book] 臨床医とコメディカルのための最新クリニカルPET,"第15章2.PET分子プローブの開発研究とその進歩"2010

Author(s)

Publisher

Data Source

[Book] 創薬研究への分子イメージング応用,"第1章3.PET分子プローブの合成法"2010

Author(s)

Publisher

Data Source

[Book] 遺伝子医学MOOK18号 創薬研究への分子イメージング応用,"第1章3.PET分子プローブの合成法"2010

Author(s)

Publisher

Data Source

[Journal Article] Detection of Cyclooxygenase-1 in Activated Microglia During Amyloid Plaque Progression: PET Studies in Alzheimer's Disease Model Mice.2016

Author(s)

Doi Hisashi 土居久志

DOI Hisashi 土居久志

[Book] 遺伝子医学MOOK18号創薬研究への分子イメージング応用,"第1章3.PET分子プローブの合成法"2010

[Journal Article] Detection of Cyclooxygenase-1 in Activated Microglia During Amyloid Plaque　Progression: PET Studies in Alzheimer's Disease Model Mice.2016