Nagumo Yasuyuki 南雲康行

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NAGUMO Yasuyuki 南雲康行

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Researcher Number	00459661
Other IDs
Affiliation (Current)	2025: 国立研究開発法人国立がん研究センター, 研究所, ユニット長
Affiliation (based on the past Project Information) *help	2022 – 2023: 国立研究開発法人国立がん研究センター, 研究所, 主任研究員 2020 – 2021: 筑波大学, 国際統合睡眠医科学研究機構, 助教 2015 – 2016: 筑波大学, 国際統合睡眠医科学研究機構, 助教 2012 – 2014: 東京女子医科大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Pain science / Basic Section 48030:Pharmacology-related Except Principal Investigator Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related / Transformative Research Areas, Section (II) / Basic Section 37030:Chemical biology-related
Keywords	Principal Investigator 神経回路再改編 / 内側毛帯線維 / 体性感覚視床 / 脳・神経 / バイアスリガンド / 難治性疼痛緩和 / オピオイド / 疼痛緩和 / κオピオイド受容体作動薬 / 新規オピオイド鎮痛薬 … More / 痛覚過敏 / VPM細胞 / GABAシナプス / 回路改編 / 体性感覚視床神経回路 / 痛覚過敏反応 / GABA シナプス / 末梢神経損傷 / GABA / 神経損傷 / 神経科学 … More Except Principal Investigator 分子設計 / 創薬化学 / 作動薬 / GPCR / オレキシン受容体 / オピオイド受容体 / オレキシン / オレキシン1受容体 / 機能解明 / 薬理評価 / オレキシン１受容体 / アゴニスト / 薬理学 / δオピオイド受容体 / κオピオイド受容体 / シグナル伝達 / Gタンパク質共役型受容体 / PETプローブ / フルオロアルキル / 拮抗薬 Less

Fundamental research for the application of a novel kappa opioid receptor agonist for medical treatment of pain reliefPrincipal Investigator
- Principal Investigator
  
  Nagumo Yasuyuki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48030:Pharmacology-related
- Research Institution
  National Cancer Center Japan
  University of Tsukuba
Construction of morphinan-based focused library
- Principal Investigator
  
  Saitoh Tsuyoshi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (B)
- Review Section
  
  Transformative Research Areas, Section (II)
- Research Institution
  University of Tsukuba
Development of novel PET probes targeting orexin 1 receptor
- Principal Investigator
  
  Saitoh Tsuyoshi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 37030:Chemical biology-related
- Research Institution
  University of Tsukuba
Development of novel selective orexin 1 receptor agonists and elucidation of the function of orexin receptors
- Principal Investigator
  
  Nagase Hiroshi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  University of Tsukuba
Changes in thalamic extrasynaptic GABA-A receptor-mediated currents following peripheral nerve injury and its influence on the remodeling of thalamic afferent fibersPrincipal Investigator
- Principal Investigator
  
  NAGUMO Yasuyuki
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pain science
- Research Institution
  University of Tsukuba
Analysis of GABA synaptic modulation on neuronal activity and the remodeling of medial lemniscal fibers after the peripheral nerve injury in the somatosensory thalamus: using lentivirus vector methodPrincipal Investigator
- Principal Investigator
  
  NAGUMO Yasuyuki
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pain science
- Research Institution
  Tokyo Women's Medical University

All 2023 2022 2021 2017 2016 2015 2013 Other

All Journal Article Presentation Book Other

[Book] トワイクロス先生のがん緩和ケア処方薬　薬効・薬理と薬の使い方2013
- Author(s)
  監訳: 武田文和、鈴木　勉、共著パート翻訳: 南雲康行
- Total Pages
  752
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-24790580
[Journal Article] Design and synthesis of novel orexin 2 receptor agonists with a 1,3,5-trioxazatriquinane skeleton2023
- Author(s)
  Mao Amezawa, Naoshi Yamamoto, Yasuyuki Nagumo, Noriki Kutsumura, Yukiko Ishikawa, Masashi Yanagisawa, Hiroshi Nagase, Tsuyoshi Saitoh
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 82 Pages: 129151-129151
- DOI
  10.1016/j.bmcl.2023.129151
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22H04918, KAKENHI-ORGANIZER-21H05111, KAKENHI-PROJECT-20H03361
[Journal Article] Design and Synthesis of Orexin 1 Receptor-Selective Agonists2023
- Author(s)
  Keita Iio, Kao Hashimoto, Yasuyuki Nagumo, Mao Amezawa, Taisei Hasegawa, Naoshi Yamamoto, Noriki Kutsumura, Katsuhiko Takeuchi, Yukiko Ishikawa, Hikari Yamamoto, Akihisa Tokuda, Tetsu Sato, Yasuo Uchida, Asuka Inoue, Ryuji Tanimura, Masashi Yanagisawa, Hiroshi Nagase, Tsuyoshi Saitoh
- Journal Title
  
  Journal of Medicinal Chemistry
  
  Volume: 66 Issue: 8 Pages: 5453-5464
- DOI
  10.1021/acs.jmedchem.2c01773
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22H04918, KAKENHI-ORGANIZER-21H05111, KAKENHI-PLANNED-21H05113, KAKENHI-PROJECT-21H04791, KAKENHI-PROJECT-20H03361
[Journal Article] Discovery of orexin 2 receptor selective and dual orexin receptor agonists based on the tetralin structure: Switching of receptor selectivity by chirality on the tetralin ring2022
- Author(s)
  Keita Iio, Tsuyoshi Saitoh, Ryuichiro Ohshita, Tsubasa Hino, Mao Amezawa, Yoshiaki Takayama, Yasuyuki Nagumo, Naoshi Yamamoto, Noriki Kustumura, Yoko Irukayama-Tomobe, Yukiko Ishikawa, Ryuji Tanimura, Masashi Yanagisawa, Hiroshi Nagase
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 60 Pages: 128555-128555
- DOI
  10.1016/j.bmcl.2022.128555
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H06095, KAKENHI-ORGANIZER-21H05111, KAKENHI-PROJECT-20H03361, KAKENHI-PROJECT-19K07314
[Journal Article] Discovery of novel orexin receptor antagonists using a 1,3,5-trioxazatriquinane bearing multiple effective residues (TriMER) librasy2022
- Author(s)
  Saitoh T, Amezawa M, Horiuchi J, Nagumo Y, Yamamoto N, Kutsumura N, Ohshita R, Tokuda A, Irukayama-Tomobe Y, Ogawa Y, Ishikawa Y, Hasegawa E, Sakurai T, Uchida Y, Sato T, Gouda H, Tanimura R, Yanagisawa M, Nagase H.
- Journal Title
  
  Eur J Med Chem
  
  Volume: 240 Pages: 114505-27
- DOI
  10.1016/j.ejmech.2022.114505
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07314, KAKENHI-PROJECT-22H04918, KAKENHI-ORGANIZER-21H05111, KAKENHI-PROJECT-20H03361
[Journal Article] Design and synthesis of novel orexin 2 receptor agonists based on naphthalene skeleton2022
- Author(s)
  Tsubasa Hino, Tsuyoshi Saitoh, Yasuyuki Nagumo, Naoshi Yamamoto, Noriki Kutsumura, Yoko Irukayama-Tomobe, Yukiko Ishikawa, Ryuji Tanimura, Masashi Yanagisawa, Hiroshi Nagase
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 59 Pages: 128530-128530
- DOI
  10.1016/j.bmcl.2022.128530
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H06095, KAKENHI-ORGANIZER-21H05111, KAKENHI-PROJECT-20H03361, KAKENHI-PROJECT-19K07314
[Journal Article] Design and Synthesis of Potent and Highly Selective Orexin 1 Receptor Antagonists with a Morphinan Skeleton and Their Pharmacologies2017
- Author(s)
  Nagase H and Yanagisawa M et al.
- Journal Title
  
  J Med Chem
  
  Volume: 60 Issue: 3 Pages: 1018-1040
- DOI
  10.1021/acs.jmedchem.6b01418
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-ORGANIZER-15H05935, KAKENHI-PROJECT-26220207, KAKENHI-PROJECT-16H05098, KAKENHI-PROJECT-15H06606, KAKENHI-PROJECT-15K19195, KAKENHI-PROJECT-15K16557
[Journal Article] 分子からせまる神経薬理学: オピオイド受容体－κ受容体－2016
- Author(s)
  南雲康行
- Journal Title
  
  Clinical Neuroscience
  
  Volume: 34 Pages: 1074-1075
- Data Source
  KAKENHI-PROJECT-15K19195
[Journal Article] 分子からせまる神経薬理学: オピオイド受容体－δ受容体－2016
- Author(s)
  南雲康行
- Journal Title
  
  Clinical Neuroscience
  
  Volume: 34 Pages: 1188-1189
- Data Source
  KAKENHI-PROJECT-15K19195
[Journal Article] 分子からせまる神経薬理学: オピオイド受容体－μ受容体－2016
- Author(s)
  南雲康行
- Journal Title
  
  Clinical Neuroscience
  
  Volume: 34 Pages: 954-955
- Data Source
  KAKENHI-PROJECT-15K19195
[Journal Article] 分子からせまる神経薬理学: オピオイド受容体－総論－2016
- Author(s)
  南雲康行
- Journal Title
  
  Clinical Neuroscience
  
  Volume: 34 Pages: 854-855
- Data Source
  KAKENHI-PROJECT-15K19195
[Journal Article] Synthesis of new opioid derivatives with a propellane skeleton and their pharmacologies: Part 5, novel pentacyclic propellane derivatives with a 6-amide side chain2015
- Author(s)
  Nakajima R, Yamamoto N, Hirayama S, Iwai T, Saitoh A, Nagumo Y, Fujii H, Nagase H.
- Journal Title
  
  Bioorg Med Chem.
  
  Volume: 23 Issue: 19 Pages: 6271-6279
- DOI
  10.1016/j.bmc.2015.08.036
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19195, KAKENHI-PROJECT-26860076, KAKENHI-INTERNATIONAL-15K21745, KAKENHI-ORGANIZER-15H05935, KAKENHI-PLANNED-15H05942, KAKENHI-PROJECT-15J03517
[Journal Article] FFA1-selective agonistic 1570..1583 activity based on docking simulation using FFA1 and GPR120 homology models2013
- Author(s)
  Masato Takeuchi
- Journal Title
  
  British Journal of Pharmacology
  
  Volume: 168 Issue: 7 Pages: 1570-1583
- DOI
  10.1111/j.1476-5381.2012.02052.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659038, KAKENHI-PROJECT-24790580
[Presentation] Analysis of orexinergic function in chronic pain-like states2023
- Author(s)
  Kao Hashimoto, Yasuyuki Nagumo, Keita Iio, Yuki Saito, Yukiko Ishikawa, Noriki Kutsumura, Takeshi Sakurai, Masashi Yanagisawa, Tsuyoshi Saitoh, Hiroshi Nagase
- Organizer
  The 11th Annual WPI-IIIS Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03361
[Presentation] オレキシン1受容体を介する疼痛制御メカニズムの解析2023
- Author(s)
  橋本佳応、南雲康行、飯尾啓太、齊藤夕貴、石川有紀子、沓村憲樹、櫻井武、柳沢正史、斉藤毅、長瀬博
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-20H03361
[Presentation] 配座制御に基づく新規テトラリン型OX2R選択的作動薬の創製2023
- Author(s)
  栗林利明、雨澤真櫻、岡田卓大、大下隆一郎、山本直司、南雲康行、沓村憲樹、入鹿山容子、石川有紀子、柳沢正史、長瀬博、斉藤毅
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-20H03361
[Presentation] 1,3,5-Trioxazatriquinane骨格を用いたオレキシン受容体作動薬の創製2022
- Author(s)
  雨澤真櫻、斉藤毅、山本直司、南雲康行、沓村憲樹、石川有紀子、柳沢正史、長瀬博
- Organizer
  第39回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-20H03361
[Presentation] 選択的オレキシン１受容体作動薬の設計と合成2022
- Author(s)
  飯尾啓太、斉藤毅、橋本佳応、南雲康行、雨澤真櫻、長谷川大晟、石川有紀子、山本直司、沓村憲樹、柳沢正史、長瀬博
- Organizer
  第39回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-20H03361
[Presentation] TriMER骨格を用いたGPCRリガンド探索ツールの開発2022
- Author(s)
  雨澤真櫻、斉藤毅、山本直司、南雲康行、沓村憲樹、石川有紀子、柳沢正史、長瀬博
- Organizer
  第17回GPCR研究会
- Data Source
  KAKENHI-PROJECT-20H03361
[Presentation] 2-メチルテトラリン誘導体を用いたオレキシン受容体作動薬の開発2022
- Author(s)
  雨澤真櫻、斉藤毅、岡田卓大、大下隆一郎、山本直司、南雲康行、沓村憲樹、入鹿山容子、石川有紀子、柳沢正史、長瀬博
- Organizer
  第66回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-20H03361
[Presentation] Design and Synthesis of Novel Orexin Receptor Antagonists with 1,3,5-Trioxazatriquinane skeleton2021
- Author(s)
  Mao Amezawa; Jumpei Horiuchi; Tsuyoshi Saitoh; Ryuichiro Ohshita; Naoshi Yamamoto; Yasuyuki Nagumo; Yukiko Ishikawa; Yoko Irukayama; Emi Hasegawa; Noriki Kutsumura; Ryuji Tanimura; Sakurai Takeshi; Masashi Yanagisawa; Hiroshi Nagase
- Organizer
  AIMECS2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03361
[Presentation] Design and Synthesis of Novel Orexin Receptor Dual Agonists with Tetralin Skeleton2021
- Author(s)
  Keita Iio, Tsuyoshi Saitoh, Ryuichiro Ohshita, Tsubasa Hino, Mao Amezawa, Sayaka Ohrui, Takahiro Okada, Yasuyuki Nagumo, Naoshi Yamamoto, Yukiko Ishikawa, Yoko Irukayama-Tomobe, Noriki Kutsumura, Masashi Yanagisawa, Hiroshi Nagase
- Organizer
  AIMECS2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03361
[Presentation] Discovery of novel orexin receptor antagonists with 1,3,5-trioxazatriquinane skeleton2021
- Author(s)
  Mao Amezawa; Tsuyoshi Saitoh; Yukiko Ishikawa; Yoko Irukayama; Emi Hasegawa; Hiroaki Gouda; Naoshi Yamamoto; Noriki Kutsumura; Yasuyuki Nagumo; Sakurai Takeshi; Masashi Yanagisawa; Hiroshi Nagase
- Organizer
  The 2021 International Chemical Congress of Pacific Basin Societies (Pacifichem)(国際学会)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03361
[Presentation] Remodeling of somatosensory thalamic neural circuit and allodynia-like mechanical hypersensitivity2015
- Author(s)
  Nagumo Y, Takeuchi Y, Miyata M.
- Organizer
  The 38th Annual Meeting of the Japan Neuroscience Society
- Place of Presentation
  神戸国際会議場、神戸国際展示場 (兵庫県神戸市)
- Year and Date
  2015-07-28
- Data Source
  KAKENHI-PROJECT-15K19195
[Presentation] Contrary changes of phasic- and tonic-inhibition onto thalamic relay neurons in mice with infraorbital nerve cut2013
- Author(s)
  Nagumo Y, Miyata M.
- Organizer
  第 90 回日本生理学会大会
- Place of Presentation
  東京: タワーホール船掘
- Data Source
  KAKENHI-PROJECT-24790580
[Presentation] Phasic-GABA current in thalamic relay neurons is reduced by peripheral nerve injury, whereas tonic-GABA current is increased2013
- Author(s)
  Nagumo Y, Miyata M
- Organizer
  第 36 会日本神経科学会年会 (Neuro 2013)
- Place of Presentation
  京都: 国立京都国際会館
- Data Source
  KAKENHI-PROJECT-24790580
[Presentation] Role of extrasynaptic GABAA receptor on the remodeling of medial lemniscal fibers in the somatosensory thalamus by peripheral nerve injury
- Author(s)
  Nagumo Y, Miyata M
- Organizer
  第 37 回日本神経科学大会 (Neuroscience 2014)
- Place of Presentation
  横浜: パシフィコ横浜
- Year and Date
  2014-09-11 – 2014-09-13
- Data Source
  KAKENHI-PROJECT-24790580
[Presentation] Enhanced tonic GABA currents after peripheral nerve injury contribute to inhibition of neuronal activity and subsequent remodeling of medial lemniscal fibers in the somatosensory thalamus
- Author(s)
  Nagumo Y, Takeuchi Y, Osaki H, Miyata M
- Organizer
  第 120 回日本解剖学会総会　第 92 回日本生理学会大会　合同大会
- Place of Presentation
  神戸: 神戸国際会議場
- Year and Date
  2015-03-21 – 2015-03-23
- Data Source
  KAKENHI-PROJECT-24790580
[]

1. Saitoh Tsuyoshi (80609933)

# of Collaborated Projects: 3 results

# of Collaborated Products: 10 results
2. Nagase Hiroshi (70383651)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
3. IRUKAYAMA Yoko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 柳沢正史

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
5. 桜井武

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Nagumo Yasuyuki 南雲 康行

NAGUMO Yasuyuki 南雲 康行

Research Projects

Research Products

Co-Researchers

Fundamental research for the application of a novel kappa opioid receptor agonist for medical treatment of pain reliefPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Construction of morphinan-based focused library

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of novel PET probes targeting orexin 1 receptor

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of novel selective orexin 1 receptor agonists and elucidation of the function of orexin receptors

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Changes in thalamic extrasynaptic GABA-A receptor-mediated currents following peripheral nerve injury and its influence on the remodeling of thalamic afferent fibersPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of GABA synaptic modulation on neuronal activity and the remodeling of medial lemniscal fibers after the peripheral nerve injury in the somatosensory thalamus: using lentivirus vector methodPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] トワイクロス先生のがん緩和ケア処方薬 薬効・薬理と薬の使い方2013

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Design and synthesis of novel orexin 2 receptor agonists with a 1,3,5-trioxazatriquinane skeleton2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Design and Synthesis of Orexin 1 Receptor-Selective Agonists2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Discovery of orexin 2 receptor selective and dual orexin receptor agonists based on the tetralin structure: Switching of receptor selectivity by chirality on the tetralin ring2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Discovery of novel orexin receptor antagonists using a 1,3,5-trioxazatriquinane bearing multiple effective residues (TriMER) librasy2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Design and synthesis of novel orexin 2 receptor agonists based on naphthalene skeleton2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Design and Synthesis of Potent and Highly Selective Orexin 1 Receptor Antagonists with a Morphinan Skeleton and Their Pharmacologies2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 分子からせまる神経薬理学: オピオイド受容体－κ受容体－2016

Author(s)

Journal Title

Data Source

Nagumo Yasuyuki 南雲康行

NAGUMO Yasuyuki 南雲康行

[Book] トワイクロス先生のがん緩和ケア処方薬　薬効・薬理と薬の使い方2013