OKUNO Tatsusada 奥野龍禎

Researcher Number	00464248
Other IDs
Affiliation (Current)	2024: 大阪大学, 大学院医学系研究科, 准教授
Affiliation (based on the past Project Information) *help	2022 – 2024: 大阪大学, 大学院医学系研究科, 准教授 2019 – 2021: 大阪大学, 医学系研究科, 准教授 2016 – 2019: 大阪大学, 医学系研究科, 助教 2016: 大阪大学医学系研究科, 助教 2011 – 2015: 大阪大学, 医学(系)研究科(研究院), 助教 2009: Osaka University, 微生物学研究所, 助教 2008 – 2009: Osaka University, 微生物病研究所, 特任研究員
Review Section/Research Field	Principal Investigator Neurology / Basic Section 52020:Neurology-related / Basic Section 51030:Pathophysiologic neuroscience-related Except Principal Investigator Neurology / Basic Section 52020:Neurology-related / Medium-sized Section 54:Internal medicine of the bio-information integration and related fields / Broad Section I / Basic Section 51030:Pathophysiologic neuroscience-related / Neurophysiology / General neuroscience / Ophthalmology
Keywords	Principal Investigator 視神経脊髄炎 / セマフォリン / 実験的自己免疫性脳脊髄炎 / EAE / ミクログリア / 筋萎縮性側索硬化症 / 縦断的免疫ダイナミクス / オミクス解析 / 重症筋無力症（MG) / 視神経脊髄炎(NMO) … More / 重症筋無力症 / RNAシークエンス / カタログ化 / タイプ１インターフェロン / インターフェロンシグネーチャー / NMO / IFN シグネーチャー / NMOSD / 脊髄炎 / 標的抗原 / モノクローナル抗体 / 自己抗体 / アクアポリン４抗体 / 慢性脊髄炎 / 血管 / 神経変性 / 血流 / 低酸素 / 虚血 / Sema3E / 多発性硬化症 / ALS / Ｍ１／Ｍ２ / Ｍ１/Ｍ２ / ＪＡＫ２阻害剤 / 炎症 / M1/M2 / GM-CSF / ＡＬＳ / 運動神経保護 / CD100 / プレキシン / iNOS / neuroinflammation / 運動ニューロン保護 / Sema4D … More Except Principal Investigator ミトコンドリアDNA / アストロサイト / 反発性軸索ガイダンス因子(RGMa) / 異常蛋白凝集 / 筋萎縮性側索硬化症(ALS) / 細胞骨格 / ALS / RGMa / バイオインフォマティクス / 次世代シークエンス / 疾患ゲノム解析 / 免疫アレルギー疾患 / シングルセル解析 / オミクス解析 / 遺伝統計学 / 統合シークエンス解析 / 免疫疾患 / 神経疾患 / 神経ガイダンス因子 / 慢性炎症 / 神経免疫クロストーク / 神経免疫クロストーく / ガイダンス因子 / 神経・免疫・代謝 / 免疫代謝 / 神経免疫代謝 / セマフォリン / 神経ガイダンス / 神経免疫代謝連関 / 慢性虚血・低酸素 / 慢性低酸素 / 慢性虚血 / 運動ニューロン病 / 代謝 / 血流改善 / 低栄養 / 筋萎縮性側索硬化症 / 神経変性 / 血管拡張 / 低灌流 / 低酸素 / 運動ニューロン疾患 / 運動神経変性 / α-synucelin / 脳神経疾患 / Exosome / α-synuclein / exosome / オートファジー / 自然免疫 / 視神経脊髄炎 / ミトコンドリアＤＮＡ / 原田病 / 硝子体濃度 / 血清濃度 / 血管新生モデル / 網膜下線維化 / SHG顕微鏡 / 炎症性眼疾患 / 視神経炎 / SEMA4A / 高次脳機能障害 / NMOSD / バイオマーカー / NMO / 多発性硬化症 / 酢酸 / PET Less

自己免疫性神経筋疾患の発症機構解明と治療カタログ化の試みPrincipal Investigator
- Principal Investigator
  
  奥野龍禎
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Osaka University
Elucidation of immune and allergic disease dynamics by integrative sequencing analysis
- Principal Investigator
  
  岡田随象
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
- Research Institution
  The University of Tokyo
細胞骨格動態制御によるALS病態改善の試み
- Principal Investigator
  
  清水幹人
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Osaka University
Investigation of interferon signature in NMOSDPrincipal Investigator
- Principal Investigator
  
  Tatsusada Okuno
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Osaka University
Treatment strategy of amyotrophic lateral sclerosis focusing on controlling spinal blood flow and metabolism
- Principal Investigator
  
  TADA Satoru
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Osaka University
Investigation on pathological implications of guidance molecules in neuro-immune-metabolism.
- Principal Investigator
  
  Kumanogoh Atsushi
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Review Section
  
  Broad Section I
- Research Institution
  Osaka University
Identification and establishment of novel autoantibody in myelitisPrincipal Investigator
- Principal Investigator
  
  Okuno Tatsusada
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Osaka University
Establishment of personalized medicine for NMO utilizing 11C-acetate PET
- Principal Investigator
  
  Nakatsuji Yuji
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  University of Toyama
  Osaka University
The serum concentration of SEMA4A in eye diseases
- Principal Investigator
  
  Yukio Sassa
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Kyushu University
  Fukuoka University
Mechanisms of mitochondrial DNA release in the CNS
- Principal Investigator
  
  Sakakibara Kaori
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Neurology
- Research Institution
  Osaka University
Analysis of propagation molecule mechanism via exosome in Parkinson's disease related gene SNCA
- Principal Investigator
  
  Kawahara Hironori
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurophysiology / General neuroscience
- Research Institution
  Kanazawa University
Trials to treat progressive MSPrincipal Investigator
- Principal Investigator
  
  Okuno Tatsusada
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Osaka University
Treatment of animal model of ALS with anti GM-CSF antibodyPrincipal Investigator
- Principal Investigator
  
  OKUNO Tatsusada
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Osaka University
A trial of amyotrophic lateral sclerosis (ALS) therapy targeting on semanhorinsPrincipal Investigator
- Principal Investigator
  
  OKUNO Tatsusada
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurology
- Research Institution
  Osaka University

[Book] Pharma Medica　MSバイオマーカーとしての血液・髄液検査2018
- Author(s)
  中辻裕司.　奥野龍禎
- Total Pages
  4
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-15K09339
[Book] Neuromyelitis Optica:Diagnosis and Treatment. Neuroimmunological Disease (Kusunoki S).2016
- Author(s)
  Nakatuji Y, Kinoshita M, Okuno T, Takata K, Koda T, Honorat JA, Sakoda S, Mochizuki H.
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-26461293
[Book] Semaphorins chapter 10: Semaphorins and Neurodegenerative Disorders2015
- Author(s)
  Okuno T, Nakatsuji Y
- Total Pages
  17
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-15K09339
[Book] 日本臨床、免疫性神経疾患の動物モデル. 視神経脊髄炎の動物モデル2015
- Author(s)
  奥野龍禎、木下允、中辻裕司、望月秀樹
- Total Pages
  9
- Publisher
  日本臨床社
- Data Source
  KAKENHI-PROJECT-15K09339
[Book] 神経系の慢性炎症2014
- Author(s)
  奥野龍禎　島上洋　望月秀樹
- Total Pages
  6
- Publisher
  北隆館
- Data Source
  KAKENHI-PROJECT-26461293
[Journal Article] Identification of double-stranded DNA in the cerebrospinal fluid of patients with acute neuromyelitis optica spectrum disorder2023
- Author(s)
  Yamamoto Mamoru、Okuno Tatsusada、Piao Jin-Lan、Shimizu Mikito、Miyamoto Katsuichi、Nukui Takamasa、Kinoshita Makoto、Koda Toru、Dini Haryuni Ratna、Mochizuki Hideki、Sugimoto Tomoyuki、Nakatsuji Yuji
- Journal Title
  
  Journal of Clinical Neuroscience
  
  Volume: 107 Pages: 129-132
- DOI
  10.1016/j.jocn.2022.12.005
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K11165, KAKENHI-PROJECT-22K07539
[Journal Article] Cell-Free DNA Derived From Neutrophils Triggers Type 1 Interferon Signature in Neuromyelitis Optica Spectrum Disorder2022
- Author(s)
  Murata Hisashi、Kinoshita Makoto、Yasumizu Yoshiaki、Motooka Daisuke、Beppu Shohei、Shiraishi Naoyuki、Sugiyama Yasuko、Kihara Keigo、Tada Satoru、Koda Toru、Konaka Hachiro、Takamatsu Hyota、Kumanogoh Atsushi、Okuno Tatsusada、Mochizuki Hideki
- Journal Title
  
  Neurology - Neuroimmunology Neuroinflammation
  
  Volume: 9 Issue: 3
- DOI
  10.1212/nxi.0000000000001149
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07822, KAKENHI-PROJECT-20K07759
[Journal Article] High cell surface expression and peptide binding affinity of HLA-DQA1*05:03, a susceptible allele of neuromyelitis optica spectrum disorders (NMOSD)2022
- Author(s)
  Beppu Shohei、Kinoshita Makoto、Wilamowski Jan、Suenaga Tadahiro、Yasumizu Yoshiaki、Ogawa Kotaro、Ishikura Teruyuki、Tada Satoru、Koda Toru、Murata Hisashi、Shiraishi Naoyuki、Sugiyama Yasuko、Kihara Keigo、Sugimoto Tomoyuki、Arase Hisashi、Standley Daron M.、Okuno Tatsusada、Mochizuki Hideki
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1 Pages: 1-12
- DOI
  10.1038/s41598-021-04074-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07822, KAKENHI-PROJECT-19H03478, KAKENHI-PROJECT-20K16577, KAKENHI-PROJECT-18H05279
[Journal Article] Anti-AQP4 autoantibodies promote ATP release from astrocytes and induce mechanical pain in rats2021
- Author(s)
  Ishikura Teruyuki、Kinoshita Makoto、Shimizu Mikito、Murata Hisashi、Beppu Shohei、Koda Toru、Tada Satoru、Miyamoto Katsuichi、Kusunoki Susumu、Sugimoto Tomoyuki、Kumanogoh Atsushi、Okuno Tatsusada、Mochizuki Hideki
- Journal Title
  
  Journal of Neuroinflammation
  
  Volume: 18 Issue: 1 Pages: 1-12
- DOI
  10.1186/s12974-021-02232-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07822, KAKENHI-PROJECT-20K16577
[Journal Article] Sema4A is implicated in the acceleration of Th17 cell-mediated neuroinflammation in the effector phase2020
- Author(s)
  Koda Toru、Namba Akiko、Kinoshita Makoto、Nakatsuji Yuji、Sugimoto Tomoyuki、Sakakibara Kaori、Tada Satoru、Shimizu Mikito、Yamashita Kazuya、Takata Kazushiro、Ishikura Teruyuki、Murata Syo、Beppu Shohei、Kumanogoh Atsushi、Mochizuki Hideki、Okuno Tatsusada
- Journal Title
  
  Journal of Neuroinflammation
  
  Volume: 17 Issue: 1 Pages: 1-9
- DOI
  10.1186/s12974-020-01757-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07822, KAKENHI-PROJECT-18K15452, KAKENHI-PROJECT-20K16577, KAKENHI-PROJECT-18K10743
[Journal Article] Mitochondrial DNA enhance innate immune responses in neuromyelitis optica by monocyte recruitment and activation2020
- Author(s)
  Mikito Shimizu, Tatsusada Okuno, Makoto Kinoshita, Hisae Sumi, Harutoshi Fujimura, Kazuya Yamashita, Tomoyuki Sugimoto, Shuhei Sakakibara, Kaori Sakakibara, Toru Koda, Satoru Tada, Teruyuki Ishikura, Hisashi Murata, Shohei Beppu, Naoyuki Shiraishi, Yasuko Sugiyama, Yuji Nakatsuji, Atsushi Kumanogoh & Hideki Mochizuki
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 13274-13274
- DOI
  10.1038/s41598-020-70203-x
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07822, KAKENHI-PROJECT-20K16577, KAKENHI-PROJECT-18K10743, KAKENHI-PROJECT-18K15451, KAKENHI-PROJECT-18K15452
[Journal Article] Next-generation sequencing identifies contribution of both class I and II HLA genes on susceptibility of multiple sclerosis in Japanese2019
- Author(s)
  Ogawa, Kotaro; Okuno, Tatsusada; Hosomichi, Kazuyoshi; Hosokawa, Akiko; Hirata, Jun; Suzuki, Ken; Sakaue, Saori; Kinoshita, Makoto; Asano, Yoshihiro; Miyamoto, Katsuichi
- Journal Title
  
  Journal of neuroinflammation
  
  Volume: 16 Issue: 1 Pages: 162-162
- DOI
  10.1186/s12974-019-1551-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17962, KAKENHI-PLANNED-15H05911, KAKENHI-PLANNED-16H06502, KAKENHI-PUBLICLY-19H05344, KAKENHI-PROJECT-17K09779, KAKENHI-PROJECT-19H03652, KAKENHI-PROJECT-18K19547
[Journal Article] Inhibition of RGMa alleviates symptoms in a rat model of neuromyelitis optica.2018
- Author(s)
  Harada K, Fujita Y, Okuno T, Tanabe S, Koyama Y, Mochizuki H, Yamashita T
- Journal Title
  
  Sci Rep
  
  Volume: 8 Issue: 1 Pages: 34-34
- DOI
  10.1038/s41598-017-18362-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09779, KAKENHI-PROJECT-17H06178
[Journal Article] Beneficial effects of fingolimod in MS patients with high serum Sema4A levels2018
- Author(s)
  Koda Toru、Namba Akiko、Nakatsuji Yuji、Niino Masaaki、Miyazaki Yusei、Sugimoto Tomoyuki、Kinoshita Makoto、Takata Kazushiro、Yamashita Kazuya、Shimizu Mikito、Fukazawa Toshiyuki、Kumanogoh Atsushi、Mochizuki Hideki、Okuno Tatsusada
- Journal Title
  
  PLoS One
  
  Volume: 13 Issue: 3 Pages: 1-10
- DOI
  10.1371/journal.pone.0193986
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09339, KAKENHI-PROJECT-18K10743, KAKENHI-PROJECT-18K15452
[Journal Article] Febuxostat ameliorates secondary progressive experimental autoimmune encephalomyelitis by restoring mitochondrial energy production in a GOT2-dependent manner.2017
- Author(s)
  Honorat JA, Nakatsuji Y, Shimizu M, Kinoshita M, Sumi-Akamaru H, Sasaki T, Takata K, Koda T, Namba A, Yamashita K, Sanda E, Sakaguchi M, Kumanogoh A, Shirakura T, Tamura M, Sakoda S, Mochizuki H, Okuno T
- Journal Title
  
  PLoS One
  
  Volume: 12
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09779
[Journal Article] Febuxostat ameliorates secondary progressive experimental autoimmune encephalomyelitis by restoring mitochondrial energy production in a GOT2-dependent manner2017
- Author(s)
  Honorat Josephe A.、Nakatsuji Yuji、Shimizu Mikito、Kinoshita Makoto、Sumi-Akamaru Hisae、Sasaki Tsutomu、Takata Kazushiro、Koda Toru、Namba Akiko、Yamashita Kazuya、Sanda Eri、Sakaguchi Manabu、Kumanogoh Atsushi、Shirakura Takashi、Tamura Mizuho、Sakoda Saburo、Mochizuki Hideki、Okuno Tatsusada
- Journal Title
  
  PLoS One
  
  Volume: 12 Issue: 11 Pages: e0187215-e0187215
- DOI
  10.1371/journal.pone.0187215
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09339, KAKENHI-PROJECT-16K15317
[Journal Article] Tumefactive brain lesion with rapid cavity formation associated with anti-aquaporin-4 antibody.2016
- Author(s)
  Uehara T, Beck G, Baba K, Mihara M, Okuno T, Sumi H, Nakatsuji Y, Mochizuki H.
- Journal Title
  
  Neurol Neuroimmunol Neuroinflamm
  
  Volume: 3 Issue: 3
- DOI
  10.1212/nxi.0000000000000230
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09339
[Journal Article] Polarization of M2 macrophages requires Lamtor1 that integrates cytokine and amino-acid signals2016
- Author(s)
  Kimura T, Nada S, Takegahara N, OkunoT, NojimaS, Kang S, Ito D, Morimoto K, Morimoto K, Hosokawa T, Hayama Y, Mitsui Y, Sakurai N, Sarashina-Kida H, Nishide M, Maeda Y, Takamatsu H, Okuzaki D, Yamada M, Okada M, Kumanogoh A.
- Journal Title
  
  Nat Commun.
  
  Volume: 7 Issue: 1 Pages: 13130-13130
- DOI
  10.1038/ncomms13130
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-26114006, KAKENHI-PROJECT-15H04296, KAKENHI-PROJECT-26461293, KAKENHI-PROJECT-15K08423, KAKENHI-PROJECT-15K09339, KAKENHI-PROJECT-16K14650
[Journal Article] LRRK1 is critical in the regulation of B-cell responses and CARMA1-dependent NF-κB activation.2016
- Author(s)
  Morimoto K, Baba Y, Shinohara H, Kang S, Nojima S, Kimura T, Ito D, Yoshida Y, Maeda Y, Sarashina-Kida H, Nishide M, Hosokawa T, Kato Y, Hayama Y, Kinehara Y, Okuno T, Takamatsu H, Hirano T, Shima Y, Narazaki M, Kurosaki T, Toyofuku T, Kumanogoh A.
- Journal Title
  
  Scientific Reports
  
  Volume: 6 Issue: 1 Pages: 25738-25738
- DOI
  10.1038/srep25738
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01195, KAKENHI-PROJECT-15H04705, KAKENHI-PROJECT-15H04746, KAKENHI-PROJECT-15J07574, KAKENHI-PROJECT-26461293, KAKENHI-PROJECT-15K08423, KAKENHI-PROJECT-15K08534, KAKENHI-PROJECT-15K09339, KAKENHI-PROJECT-16K15217
[Journal Article] 脱髄疾患の免疫病態研究最前線と細胞性免疫マーカー　Immune pathomechanism and biomarkers for cell-mediated immunity in demyelinating diseases2016
- Author(s)
  奥野龍禎、中辻裕司、　望月秀樹
- Journal Title
  
  最新医学
  
  Volume: 71 Pages: 1111-1116
- Data Source
  KAKENHI-PROJECT-15K09339
[Journal Article] Reply to comment on: Dietary Yeasts Reduce Inflammation in Central Nerve System via Microflora2015
- Author(s)
  Takata K, Tomita T, Okuno T, Kinoshita M, Koda T, Honorat JA, Takei M, Hagihara K, Sugimoto T, Mochizuki H, Sakoda S, Nakatsuji Y.
- Journal Title
  
  Ann Clin Transl Neurol
  
  Volume: 2（11） Issue: 11 Pages: 1040-1040
- DOI
  10.1002/acn3.258
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09339
[Journal Article] The role of gut microbiota and diet in experimental autoimmune encephalitis and multiple sclerosis2015
- Author(s)
  Okuno T, Nakatsuji Y, Kinoshita M, Takata K, Koda T, Yamashita K, Nanba A, Mochizuki H.
- Journal Title
  
  Clin Exp Neuroimm
  
  Volume: 6 Pages: 30-37
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09339
[Journal Article] The role of gut microbiota and diet in EAE and MS2015
- Author(s)
  奥野、木下、中辻、望月
- Journal Title
  
  Clinical & Experimental Neuroimmunology
  
  Volume: 6 Issue: S1 Pages: 30-37
- DOI
  10.1111/cen3.12270
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461293
[Journal Article] mTOR Complex Signaling through the SEMA4A-Plexin B2 Axis Is Required for Optimal Activation and Differentiation of CD8+ T Cells.2015
- Author(s)
  Ito D, Nojima S*, Nishide M, Okuno T, Takamatsu H, Kang S, Kimura T, Yoshida Y, Morimoto K, Maeda Y, Hosokawa T, Toyofuku T, Ohshima J, Kamimura D, Yamamoto M, Murakami M, Morii E, Rakugi H, Isaka Y, Kumanogoh A*. (* correspondence)
- Journal Title
  
  J Immunol.
  
  Volume: 195 Issue: 3 Pages: 934-943
- DOI
  10.4049/jimmunol.1403038
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08423, KAKENHI-PROJECT-26461293, KAKENHI-PROJECT-15H06382, KAKENHI-PROJECT-25860357
[Journal Article] Dietary Yeasts Reduce Inflammation in Central Nerve System via Microflora2015
- Author(s)
  Takata K,　Tomita T, Okuno T, Kinoshita M, Koda T, Honorat JA, Takei M, Hagihara K, Sugimoto T, Mochizuki H, Sakoda S, Nakatsuji Y
- Journal Title
  
  Annals of Clinical and Translational Neurology
  
  Volume: ２ Issue: 1 Pages: 56-66
- DOI
  10.1002/acn3.153
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25860712, KAKENHI-PROJECT-26461293
[Journal Article] 11C-Acetate PET Imaging in Patients with Multiple Sclerosis.2014
- Author(s)
  Takata K, Kato H, Shimosegawa E, Okuno T, Koda T, Sugimoto T, Mochizuki H, Hatazawa J, Nakatsuji Y.
- Journal Title
  
  PLoS One.
  
  Volume: 9 Issue: 11 Pages: e111598-e111598
- DOI
  10.1371/journal.pone.0111598
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24249077, KAKENHI-PROJECT-25860712, KAKENHI-PROJECT-26461293, KAKENHI-PROJECT-26462204
[Journal Article] Sema4A inhibits the therapeutic effect of IFN-βin EAE2014
- Author(s)
  Koda T, Okuno T, Takata K, Honorat JA, Kinoshita M, Tada S, Moriya M, Sakoda S, Mochizuki H, Kumanogoh A, Nakatsuji Y
- Journal Title
  
  J Neur oimmunol
  
  Volume: 5728(14) Pages: 2-2
- Data Source
  KAKENHI-PROJECT-23591244
[Journal Article] Sema4A inhibits the therapeutic effect of IFN-β in EAE.2014
- Author(s)
  Koda T, Okuno T, Takata K, Honorat JA, Kinoshita M, Tada S, Moriya M, Sakoda S, Mochizuki H, Kumanogoh A, Nakatsuji Y
- Journal Title
  
  J Neuroimmunol.
  
  Volume: 268(1-2) Issue: 1-2 Pages: 43-9
- DOI
  10.1016/j.jneuroim.2013.12.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591244, KAKENHI-PROJECT-24790883
[Journal Article] Partial suppression of M1microglia by Janus kinase 2 inhibitor does not protect against neurodegeneration in animal models of amyotrophic lateral sclerosi2014
- Author(s)
  Tada S, Okuno T, Hitoshi Y, Yasui T, Honorat J, Takata K, Koda T, Shimagami H, Chi-Jing C, Namba A,Sugimoto T, Sakoda S, Mochizuki H, Kikutani H, Nakatsuji Y
- Journal Title
  
  J Neuroinflammation
  
  Volume: 11 Issue: 1 Pages: 179-179
- DOI
  10.1186/s12974-014-0179-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461293
[Journal Article] A point mutation in Semaphorin 4A associates with defective endosomal sorting and causes retinal degeneration2013
- Author(s)
  Nojima, S., Toyofuku, T., Kamao, H., Ishigami, C., Kaneko, J., Okuno, T., Takamatsu, H., Ito, D., Kang, S., Kimura, T., Yoshida, Y., Morimoto, K., Maeda, Y., Ogata, A., Ikawa, M., Morii, E., Aozasa, K., Takagi, J., Takahashi, M. & Kumanogoh, A
- Journal Title
  
  Nature communications
  
  Volume: 4 Pages: 1406-1406
- Data Source
  KAKENHI-PROJECT-23591244
[Journal Article] A point mutation in Semaphorin 4A associates with defective endosomal sorting and causes retinal degeneration2013
- Author(s)
  Nojima S, et al.
- Journal Title
  
  Nat Commun
  
  Volume: 4 Issue: 1 Pages: 1406-1406
- DOI
  10.1038/ncomms2420
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20670006, KAKENHI-PROJECT-22247010, KAKENHI-PROJECT-23390069, KAKENHI-PROJECT-23590425, KAKENHI-PROJECT-23591244, KAKENHI-PROJECT-23790444, KAKENHI-ORGANIZER-24111001, KAKENHI-PLANNED-24111006, KAKENHI-PROJECT-24651260
[Journal Article] Xanthine oxidase mediates axonal and myelin loss in a murine model of multiple sclerosis.2013
- Author(s)
  Honorat JA, Kinoshita M, Okuno T, Takata K, Koda T, Tada S, Shirakura T, Fujimura H, Mochizuki H, Sakoda S, Nakatsuji Y.
- Journal Title
  
  PLoS One.
  
  Volume: 8;8(8) Issue: 8 Pages: e71329-e71329
- DOI
  10.1371/journal.pone.0071329
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591244, KAKENHI-PROJECT-24790883
[Journal Article] A case of progressive ataxia and palatal tremor (PAPT) with ear clicks.2013
- Author(s)
  Sumikura H, Okuno T, Takahashi MP, Araki K, Kitagawa K, Mochizuki H.
- Journal Title
  
  Clinical Neurology
  
  Volume: 53(3) Pages: 224-8
- NAID
  40019608624
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591244
[Journal Article] A case of chronic active Epstein-Barr virus infection associated with recurrent cerebellar ataxia and skin eruptions.2013
- Author(s)
  Araki K, Okuno T, Honorat JA, Kinoshita M, Takahashi MP, Mizuki M, Kitagawa K, Mochizuki H
- Journal Title
  
  Clinical Neurology
  
  Volume: 53(2) Pages: 119-24
- NAID
  40019583031
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591244
[Journal Article] Roles of Sema4A in Multiple Sclerosis and IFN-βTherapy Efficacy2013
- Author(s)
  Nakatsuji Y, Okuno T, Koda T, Takata K, Honorat JA, Mochizuki H, Kumanogoh A
- Journal Title
  
  Clinical Experimental Neur oimmunology
  
  Volume: 4 Pages: 274-282
- Data Source
  KAKENHI-PROJECT-23591244
[Journal Article] BAFF controls neural cell survival through BAFF receptor.2013
- Author(s)
  Tada S, Yasui T, Nakatsuji Y, Okuno T, Koda T, Mochizuki H, Sakoda S, Kikutani H
- Journal Title
  
  PLoS One.
  
  Volume: 29;8(7) Issue: 7 Pages: e70924-e70924
- DOI
  10.1371/journal.pone.0070924
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591244, KAKENHI-PROJECT-24590550, KAKENHI-PROJECT-24790883
[Journal Article] Xanthine oxidase mediates axonal and myelin loss in a murine model of multiple sclerosis2013
- Author(s)
  Honorat JA, Kinoshita M, Okuno T, Takata K, Koda T, Mochizuki H, Nakatsuji Y
- Journal Title
  
  PLoS One
  
  Volume: 8(8)
- Data Source
  KAKENHI-PROJECT-23591244
[Journal Article] BAFF controls neural cell survival through BAFF receptor2013
- Author(s)
  Tada S, Yasui T, Nakatsuji Y Okuno T, Koda T, Mochizuki H, Sakoda S, Kikutani H
- Journal Title
  
  PLoS One
  
  Volume: 8(7)
- Data Source
  KAKENHI-PROJECT-23591244
[Journal Article] Elevation of Sema4A implicates Th cell skewing and the efficacy of IFN-βtherapy in multiple sclerosis2012
- Author(s)
  Nakatsuji Y, Okuno T, Moriya M, Sugimoto T, Kinoshita M, Takamatsu H, i Nojima S, Kimura T, Kang S, Ito D, Nakagawa Y, Toyofuku T, Takata K, Nakano M, Kubo M, Suzuki S, Matsui-Hasumi A, Uto-Konomi A, Ogata A, Mochizuki H, Sakoda S, Kumanogoh A
- Journal Title
  
  Journal of Immunology
  
  Volume: 188 Pages: 4858-65
- Data Source
  KAKENHI-PROJECT-23591244
[Journal Article] Intestinal epithelial cell-derived semaphorin 7A negatively regulates development of colitis via αvβ1 integrin.2012
- Author(s)
  Kang S, Okuno T, Takegahara N, Takamatsu H, Nojima S, Kimura T, Yoshida Y, Ito D, Ohmae S, You DJ, Toyofuku T, Jang MH, Kumanogoh A
- Journal Title
  
  Journal of Immunology
  
  Volume: 188(3) Pages: 1108-1116
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591244
[Journal Article] Elevation of Sema4A implicates Th cell skewing and the efficacy of interferon-β therapy in multiple sclerosis.2012
- Author(s)
  Nakatsuji Y, Okuno T et al.
- Journal Title
  
  Journal of Immunology.
  
  Volume: 188(10) Pages: 4858-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591244
[Journal Article] The role of immune semaphorins in multiple sclerosis.2011
- Author(s)
  Okuno T, Nakatsuji Y, Kumanogoh A.
- Journal Title
  
  FEBS Letters.
  
  Volume: 585 Pages: 3829-3835
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591244
[Journal Article] RGMa modulates T cell responses and is involved in autoimmune encephalomyelitis2011
- Author(s)
  Muramatsu R, , Kubo T, Mori M, Nakamura Y, Fujita Y, Akutsu T, Okuno T, Taniguchi J, Kumanogoh A, Yoshida M, Mochizuki H, , Kuwabara S, Yamashita T
- Journal Title
  
  Nature Medicine
  
  Volume: 17 Pages: 488-94
- Data Source
  KAKENHI-PROJECT-23591244
[Journal Article] The role of immune semaphorins in multiple sclerosis2011
- Author(s)
  Okuno T, Nakatsuji Y, Kumanogoh A
- Journal Title
  
  FEBS Letter
  
  Volume: 585 Pages: 3829-35
- Data Source
  KAKENHI-PROJECT-23591244
[Journal Article] 多発性硬化症の発症とSema4D臨床免疫2010
- Author(s)
  奥野龍禎, 熊ノ郷淳
- Journal Title
  
  アレルギー科 53(5)
  
  Pages: 468-474
- Data Source
  KAKENHI-PROJECT-20790611
[Journal Article] Regulation of immune cell responses by semaphorins and their receptors.2010
- Author(s)
  Takamatsu H, Okuno T, Kumanoeoh A.
- Journal Title
  
  Cellular & Molecular Immunology 7(2)
  
  Pages: 83-88
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790611
[Journal Article] A midline switch of receptor processing regulates commissural axon guidance in vertebrates.2010
- Author(s)
  Nawabi H, Briancon-Marjolletl A, Clark C, Sanyas I, Takamatsu H, Okuno T, Kumanogoh A, Bozonl M, Takeshima K, Yoshida Y, Moret F, Abouzidl K, Castellani V
- Journal Title
  
  Genes & Development 15;24(4)
  
  Pages: 396-410
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790611
[Journal Article] A midline switch of receptor processing regulates commissural axon guidance in vertebrates2010
- Author(s)
  Nawabi H, Briancon-Marjollet1 A, Clark C, Sanyas I, Takamatsu H, Okuno T Kumanogoh A, Bozon1 M, Takeshima K, Yoshida Y, Moret F, Abouzid1 K, Castellani V
- Journal Title
  
  Genes & Development 24(4)
  
  Pages: 396-410
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790611
[Journal Article] Roles of Sema4D-Plexin-B1 Interactions in the Central Nervous System for Pathogenesis of Experimental Autoimmune Encephalomyelitis.2010
- Author(s)
  Okuno T, Nakatsuji Y, Moriya M, Takamatsu H, Nojima S, Takegahara N, Toyofuku T, Nakagawa Y, Kang S, Friedel RH, Sakoda S, Kikutani H, Kumanogoh A
- Journal Title
  
  Journal of Immunology 184(3)
  
  Pages: 1499-1506
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790611
[Journal Article] Regulation of immune cell responses by semaphorins and their receptors2010
- Author(s)
  Takamatsu H, Okuno T, Kumanogoh A
- Journal Title
  
  Cellular & Molecular Immunology 7(2)
  
  Pages: 83-88
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790611
[Journal Article] Kumanogoh A Roles of Sema4D-Plexin-B1 Interactions in the Central Nervous System for Pathogenesis of Experimental Autoimmune Encephalomyelitis2010
- Author(s)
  Okuno T, Nakatsuji Y, Moriya M, Takamatsu H, Nojima S, Takegahara N, Toyofuku T, Nakagawa Y, Kang S, Friedel RH, Sakoda S, Kikutani H
- Journal Title
  
  Journal of Immunology 184(3)
  
  Pages: 1499-506
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790611
[Journal Article] Neuromyelitis optica: Passive transfer to rats by human immunoglobulin2009
- Author(s)
  Kinoshita M, Nakatsuji Y, Kimura T, Moriya M, Takata K, Okuno T, Kumanogoh A, Kajiyama K, Yoshikawa H, Sakoda S
- Journal Title
  
  Biochem Biophys Res Commun. 4;386(4)
  
  Pages: 623-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790611
[Journal Article] Astrocytic necrosis is induced by anti-aquaporin-4 antibody-positive serum2009
- Author(s)
  Kinoshita M., Y. Nakatsuji, M. Moriya, T. Okuno, A. Kumanogoh, M. Nakano, T. Takahashi, K. Fujihara, K. Tanaka, S. Sakoda
- Journal Title
  
  Neuroreport 20
  
  Pages: 508-512
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790611
[Journal Article] Sema4DとNeuroinflammatlon2008
- Author(s)
  奥野龍禎, 中辻裕司, 森谷真之, 佐古田三郎, 熊ノ郷淳
- Journal Title
  
  神経免疫学 2
  
  Pages: 177-181
- Data Source
  KAKENHI-PROJECT-20790611
[Journal Article] Edaravone, a free radical scavenger, ameliorates experimental autoirnmune encephalomyelitis2008
- Author(s)
  Moriya M, Nakatsuji Y, Miyamoto K, Okuno T, Kinoshita M, Kumanogoh A, Kusunoki S, Sakoda S
- Journal Title
  
  Neuroscience letter 440
  
  Pages: 323-326
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790611
[Journal Article]2008
- Author(s)
  Makino N, Toyofuku T, Takegahara N, Takamatsu H, Okuno T, Nakagawa Y, Kang S, Nojima S, Hori M, Kikutani H, Kumanogoh A.
- Journal Title
  
  FEBS Left. 582(28)
  
  Pages: 3935-40
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790611
[Journal Article] Role of Sema4D in neuroinflammation2008
- Author(s)
  Tatsusada Okuno
- Journal Title
  
  Neuroinnumology 16
  
  Pages: 177-181
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790611
[Presentation] 好中球由来セルフリーDNAとNMO2022
- Author(s)
  村田尚　奥野龍禎
- Organizer
  神経免疫学会
- Data Source
  KAKENHI-PROJECT-20K07759
[Presentation] 患者由来レコンビナントAQP4モノクローナル抗体を用いたNMOの病態解析2018
- Author(s)
  清水幹人、奥野龍禎　木下允、甲田亨、南波明子、山下和哉、石倉照之、中辻祐司、、望月秀樹
- Organizer
  第30回日本神経免疫学会学術大会
- Data Source
  KAKENHI-PROJECT-17K09779
[Presentation] Cerebrospinal fluid mitochondrial DNA elicits innate immune response in NMOSD2018
- Author(s)
  Yamashita K, Kinoshita M, Miyamoto K, Namba A, Shimizu M, Koda T, Nakatsuji Y, Kumanogoh A, Kusunoki S, Mochizuki H, Okuno T
- Organizer
  ECTRIMS
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09779
[Presentation] Amelioration of secondary progressive experimental Autoimmmune encephalomyelitis by restoring mitochondrial enegy production in a GOT2-dependent manner2017
- Author(s)
  Kinoshita M, Honorat A, Okuno T, Nakatsuji Y, Shimizu M, Namba A, Yamashita K, Shirakura T, Mochizuki H.
- Organizer
  7th Joint ECTRIMS-ACTRIMS Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09339
[Presentation] mTOR signaling plays a crucial role in IFN-β non-responsiveness in MS patients with high serum Sema4A levels2017
- Author(s)
  Namba A, Okuno T, Koda T, Yamashita M, Shimizu m, Kinoshita M, Kumanogho A, Miyazaki Y, Niino M, Miyamoto K, Nakatsuji Y, Mochizuki H
- Organizer
  7th Joint ECTRIMS-ACTRIMS Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09339
[Presentation] Elevation of serum Sema4A in neuromyelitis optica spectrum disorders (NMOSD)2016
- Author(s)
  Kaori Sakakibara, Tatsusada Okuno, Yuji Nakatsuji, Hideki Mochizuki, Atsushi Kumanogoh
- Organizer
  16th International Congress of Immunology
- Place of Presentation
  Melbourne, Australia
- Year and Date
  2016-08-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H06372
[Presentation] 多発性硬化症のフィンゴリモドによる治療効果とSema4A値の解析2016
- Author(s)
  甲田亨、奥野龍禎、中辻裕司、宮崎雄生、新野正明、深澤俊行、南波明子、山下和哉、熊ノ郷淳、佐古田三郎、望月秀樹
- Organizer
  日本神経学会
- Place of Presentation
  神戸
- Year and Date
  2016-05-19
- Data Source
  KAKENHI-PROJECT-15K09339
[Presentation] 多発性硬化症患者における血清Sema4A値高値群の臨床的特徴．2016
- Author(s)
  南波明子，山下和哉，甲田亨，奥野龍禎，熊ノ郷淳，中辻裕司，望月秀樹．
- Organizer
  57回日本神経学会学術大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-26461293
[Presentation] 多発性硬化症患者における血清Sema4A高値群の臨床的特徴と、IFN-β開始後5年間のNEDA達成率．2016
- Author(s)
  南波明子，奥野龍禎，甲田亨，宮崎雄生，新野正明，宮本勝一，楠進，熊ノ郷淳，中辻裕司，望月秀樹
- Organizer
  第28回日本神経免疫学会学術集会
- Place of Presentation
  長崎
- Data Source
  KAKENHI-PROJECT-26461293
[Presentation] 多発性硬化症治療選択バイオマーカーＳｅｍａ４Ａ～フィンゴリモドとの相関について2016
- Author(s)
  甲田亨、奥野龍禎、中辻裕司、宮崎雄生、新野正明、深沢俊行、南波明子，山下和哉、清水幹人、熊ノ郷淳、佐古田三郎、望月秀樹．
- Organizer
  第28回　日本神経免疫学会学術集会
- Place of Presentation
  長崎
- Year and Date
  2016-09-29
- Invited
- Data Source
  KAKENHI-PROJECT-26461293
[Presentation] NMOsdにおいて血中Sema4Aは増加する2016
- Author(s)
  榊原佳織，奥野龍禎，甲田亨，宮崎雄生，新野正明，宮本勝一，楠進，深沢俊行，熊ノ郷淳，望月秀樹　中辻裕司．
- Organizer
  第28回　日本神経免疫学会学術集会
- Place of Presentation
  長崎
- Year and Date
  2016-09-29
- Data Source
  KAKENHI-PROJECT-15H06372
[Presentation] NMOsdにおいて血中Sema4Aは増加する2016
- Author(s)
  奥野龍禎、甲田亨、宮崎雄生、新野正明、宮本勝一、楠進、深沢俊行、熊ノ郷淳、望月秀樹、中辻裕司
- Organizer
  日本神経学会
- Place of Presentation
  神戸
- Year and Date
  2016-05-19
- Data Source
  KAKENHI-PROJECT-15K09339
[Presentation] Elevation of serum Sema4A in neuromyelitis optica spectrum disorders (NMOSD)2016
- Author(s)
  Kaori Sakakibara, Tatsusada Okuno, Yuji Nakatsuji, Hideki Mochizuki, Atsushi Kumanogoh
- Organizer
  International Congress of Immunology
- Place of Presentation
  Melbourne, Australia
- Year and Date
  2016-08-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09339
[Presentation] 多発性硬化症治療選択バイオマーカーＳｅｍａ４Ａ～フィンゴリモドとの相関について2016
- Author(s)
  甲田亨、奥野龍禎、中辻裕司、宮崎雄生、新野正明、深沢俊行、南波明子，山下和哉、清水幹人、熊ノ郷淳、佐古田三郎、望月秀樹
- Organizer
  日本神経免疫学会
- Place of Presentation
  長崎
- Year and Date
  2016-09-29
- Data Source
  KAKENHI-PROJECT-15K09339
[Presentation] 多発性硬化症患者における血清Sema4A高値群の臨床的特徴と、IFN-β開始後5年間のNEDA達成率2016
- Author(s)
  南波明子，奥野龍禎，甲田亨，宮崎雄生，新野正明，宮本勝一，楠進，熊ノ郷淳，中辻裕司，望月秀樹
- Organizer
  日本神経免疫学会
- Place of Presentation
  長崎
- Year and Date
  2016-09-29
- Data Source
  KAKENHI-PROJECT-15K09339
[Presentation] コハク酸はミトコンドリアストレスを介して多発性硬化症動物モデルを悪化させる2016
- Author(s)
  奥野龍禎，高田和城，山下和哉，甲田亨，望月秀樹，中辻裕司
- Organizer
  日本神経免疫学会
- Place of Presentation
  長崎
- Year and Date
  2016-09-29
- Data Source
  KAKENHI-PROJECT-15K09339
[Presentation] NMOsdにおいて血中Sema4Aは増加する2016
- Author(s)
  榊原佳織，奥野龍禎，甲田亨，宮崎雄生，新野正明，宮本勝一，楠進，深沢俊行，熊ノ郷淳，望月秀樹　中辻裕司．
- Organizer
  第28回　日本神経免疫学会学術集会
- Place of Presentation
  長崎
- Data Source
  KAKENHI-PROJECT-26461293
[Presentation] Sema4A as a biomarker for the selection of treatment of MS2016
- Author(s)
  uji Nakatsuji, Toru Koda, Tatsusada Okuno, Yusei Miyazaki, Masaaki Niino, Toshiyuki Fukazawa, Kazushiro Takata,　Akiko Namba, Kazuya Yamashita, Mikito Shimizu, Makoto Kinoshita, Saburo Sakoda, Atsushi Kumanogoh, Hideki Mochizuki
- Organizer
  Congress of the European Committee for Treatment and Research in Multiple Sclerosis
- Place of Presentation
  London, England
- Year and Date
  2016-09-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09339
[Presentation] フェブキソスタットは神経細胞のミトコンドリア機能を回復し二次進行型ＥＡＥを緩和する2016
- Author(s)
  清水幹人, J.A.Honorat, 奥野龍禎，木下允，高田和城，甲田亨，白倉尚，田村みずほ，中辻裕司，望月秀樹
- Organizer
  日本神経免疫学会
- Place of Presentation
  長崎
- Year and Date
  2016-09-29
- Data Source
  KAKENHI-PROJECT-15K09339
[Presentation] 多発性硬化症患者における血清Sema4A値高値群の臨床的特徴2016
- Author(s)
  南波明子，山下和哉，甲田亨，奥野龍禎，熊ノ郷淳，中辻裕司，望月秀樹
- Organizer
  日本神経学会
- Place of Presentation
  神戸
- Year and Date
  2016-05-19
- Data Source
  KAKENHI-PROJECT-15K09339
[Presentation] 多発性硬化症治療選択バイオマーカーSema4Aについての検討2015
- Author(s)
  甲田亨、奥野龍禎、中辻裕司、宮崎雄生、新野正明、深澤俊行、熊ノ郷淳、佐古田三郎、望月秀樹
- Organizer
  日本神経治療学会
- Place of Presentation
  名古屋
- Year and Date
  2015-11-26
- Data Source
  KAKENHI-PROJECT-15K09339
[Presentation] プロスタグランジンI2 アゴニストであるONO-1301はALSモデル動物の神経変性を抑制する。2014
- Author(s)
  多田智、安居輝人、奥野龍禎、中辻裕司、酒井芳紀、宮川繁、澤芳樹、菊谷仁、佐古田三郎、望月秀樹
- Organizer
  第55回日本神経学会学術大会
- Place of Presentation
  福岡
- Year and Date
  2014-05-22
- Data Source
  KAKENHI-PROJECT-26461293
[Presentation] 血清Sema4A増加を示すNMO spectrum disordersの臨床的特徴の解析2014
- Author(s)
  奥野龍禎、甲田亨、宮本勝一、中辻裕司、高田和城、オノラジョセフ、木下允、楠進、熊ノ郷淳、望月秀樹
- Organizer
  第55回日本神経学会学術大会
- Place of Presentation
  福岡
- Year and Date
  2014-05-22
- Data Source
  KAKENHI-PROJECT-26461293
[Presentation] プロスタグランジンI2アゴニストであるONO-1301はALSモデル動物の神経変性を抑制する2013
- Author(s)
  多田智、安居輝人、奥野龍禎、中辻裕司、酒井芳紀、宮川繁、澤芳樹、菊谷仁、佐古田三郎、望月秀樹
- Organizer
  第54回日本神経学会学術大会
- Place of Presentation
  東京(ポスター)
- Data Source
  KAKENHI-PROJECT-23591244
[Presentation] BAFF controls neural cell survival through BAFF receptor.2013
- Author(s)
  Tada S, Yasui T, Nakatsuji Y, Okuno T, Mochizuki H, Sakoda S, Kikutani H
- Organizer
  XXI WORLD CONGRESS OF NEUROLOGY
- Place of Presentation
  Vienna, Austria
- Data Source
  KAKENHI-PROJECT-23591244
[Presentation] BAFF controls neural cell survival through BAFF receptor2013
- Author(s)
  Tada S, Yasui T, Nakatsuji Y, Okuno T, Mochizuki H, Sakoda S, Kikutani H
- Organizer
  XXI WORLD CONGRESS OF NEUROLOGY
- Place of Presentation
  Vienna, Austria
- Data Source
  KAKENHI-PROJECT-23591244
[Presentation] Involvement of Sema4A in Th17 pathogenesis of multiple sclerosis2009
- Author(s)
  奥野龍禎
- Organizer
  日本免疫学会総会、学術集会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20790611
[Presentation] ROLE OF SEMA4D IN THE NEUROINFLAMMATION OF EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS, International Congress of Neuroimmunology2008
- Author(s)
  Tatsusada Okuno, Yuji Nakatsuji, Saburo Sakoda, Atsushi Kumanogoh
- Organizer
  アメリカ合衆国フォートワース
- Place of Presentation
  アメリカ合衆国フォートワース
- Data Source
  KAKENHI-PROJECT-20790611
[Presentation] ROLE OF SEMA4D IN THE NEUROINFLAMMATION OF EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS2008
- Author(s)
  Tatsusada Okuno
- Organizer
  International Congress of Neuroimmunology
- Place of Presentation
  アメリカ合衆国フォートワース
- Year and Date
  2008-10-29
- Data Source
  KAKENHI-PROJECT-20790611
[Presentation] Involvement of Sema4D/CD100 in neuroinflammation of experimental autoimmuneencephalomyelitis2008
- Author(s)
  Tatsusada Okuno, Hyota Takamatsu, Noriko Takegahara, Hitoshi Kikutani, Atsushi Kumanogoh
- Organizer
  日本免疫学会総会、学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20790611
[Presentation] 実験的自己免疫性脳脊髄炎の病巣における免疫セマフォリンSema4D/CD100の役割2008
- Author(s)
  奥野龍禎、中辻裕司, 森谷真之, 佐古閏三郎, 熊ノ郷淳
- Organizer
  神経免疫学会学術集会
- Place of Presentation
  新潟
- Data Source
  KAKENHI-PROJECT-20790611
[Presentation] Involvement of Sema4A in multiple sclerosis and neuromyelitis optica.
- Author(s)
  Tatsusada Okuno, Toru Koda, Katsuichi Miyamoto, Kazushiro Takata, Josephe A. Honorat, Susumu Kusunoki, Atsushi Kumanogoh, Yuji Nakatsuji, Hideki Mochizuki.
- Organizer
  The 12th International Congress of Neuroimmunology.
- Place of Presentation
  Ｍainz, Ｇermany
- Year and Date
  2014-11-09 – 2014-11-13
- Data Source
  KAKENHI-PROJECT-26461293
[Presentation] ALSモデルマウスにおけるM1/M2活性化とその制御による治療の試み
- Author(s)
  奥野龍禎
- Organizer
  日本神経学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23591244
[Presentation] Regulation of microglial axis by T lymphocytes in neurodegenerative disorders
- Author(s)
  奥野龍禎
- Organizer
  脳内環境若手シンポジウム
- Place of Presentation
  京都平安ホテル
- Invited
- Data Source
  KAKENHI-PROJECT-23591244

1. TADA Satoru (70626530)

# of Collaborated Projects: 4 results

# of Collaborated Products: 15 results
2. Nakatsuji Yuji (20332744)

# of Collaborated Projects: 3 results

# of Collaborated Products: 45 results
3. Hideki Mochizuki (90230044)

# of Collaborated Projects: 2 results

# of Collaborated Products: 11 results
4. Atsuhi Kumanogoh (10294125)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 甲田亨 (70626134)

# of Collaborated Projects: 2 results

# of Collaborated Products: 22 results
6. 清水幹人 (30817507)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
7. Yukio Sassa (80580315)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. Sakakibara Kaori (40621280)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
9. Kawahara Hironori (00424177)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. HANAYAMA Rikinari (40403191)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. FUJIMURA Harutoshi (20263246)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. KAWASAKI Hiroshi (50303904)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. SHINMYO Yohei (00418831)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. SATO Makoto (30345235)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. YASUGI Tetsuo (90508110)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 南波明子 (80774504)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
17. 山下和哉 (40774518)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
18. 石橋達朗 (30150428)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 向野利寛 (40117106)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 福島修一郎 (40362644)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 吉田茂生 (50363370)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 安井武史 (70314408)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 岡田随象 (70727411)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 田中良哉 (30248562)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 駒形嘉紀 (60281995)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 竹島雄介 (70893288)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 熊坂夏彦 (80525527)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. 藤本学 (90272591)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. 王青波 (00916033)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. 白石直之 (10882285)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. 坂口学 (70432474)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. 大倉永也 (20300949)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. HATAZAWA Jun

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
34. SHIMOSEGAWA Eku

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
35. TAKATA Kazushiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
36. 鈴木顕

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
37. 熊郷淳

# of Collaborated Projects: 0 results

# of Collaborated Products: 7 results
38. 山本真守

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
39. 岡田雅人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
40. 篠原久明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
41. 野島聡

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

OKUNO Tatsusada 奥野 龍禎

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自己免疫性神経筋疾患の発症機構解明と治療カタログ化の試みPrincipal Investigator

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Investigation of interferon signature in NMOSDPrincipal Investigator

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Identification and establishment of novel autoantibody in myelitisPrincipal Investigator

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Trials to treat progressive MSPrincipal Investigator

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Treatment of animal model of ALS with anti GM-CSF antibodyPrincipal Investigator

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A trial of amyotrophic lateral sclerosis (ALS) therapy targeting on semanhorinsPrincipal Investigator

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OKUNO Tatsusada 奥野龍禎

[Book] Pharma Medica　MSバイオマーカーとしての血液・髄液検査2018