Makinodan Manabu 牧之段学

… Alternative Names

Researcher Number	00510182
Other IDs
Affiliation (Current)	2020: 奈良県立医科大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2020: 奈良県立医科大学, 医学部, 准教授 2015 – 2020: 奈良県立医科大学, 医学部, 講師 2015: 奈良県立医科大学, 医学部, 助教 2010 – 2011: 奈良県立医科大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Psychiatric science / Biological Sciences / Basic Section 52030:Psychiatry-related Except Principal Investigator Psychiatric science / Complex systems / Basic Section 52030:Psychiatry-related / Basic Section 51020:Cognitive and brain science-related
Keywords	Principal Investigator 前頭前野 / ミエリン / 自閉スペクトラム症 / 小児期体験 / シナプス / オリゴデンドロサイト / クプリゾン / 隔離飼育 / 海馬 / MRI … More Except Principal Investigator 統合失調症 / モチベーション / やる気 / 現代うつ / ひきこもり / ミクログリア / サイトカイン / トランスレーショナルリサーチ / モデルマウス / 自閉症 / 甲状腺ホルモン / セロトニン / 小脳 / カテコールアミン / ノックアウトマウス / 行動解析 / オランザピン / 体重増加 / ガラニン / 脂肪細胞 / Olig2 / ニューレグリン / 末梢神経伝導速度 / 拡散テンソル画像 / iPS細胞 / 末梢神経伝道速度 / 前頭葉 / 社会経験 / 興奮性 / 神経細胞 / 発達 / 前頭前野 / h-current / 錐体細胞 / 社会的経験 / 社会的隔離 / 興奮性後シナプス電流 / 膜興奮性 / 内側前頭前野 / 興奮性シナプス伝達 / 意志力 / 脳機能 / 内発的動機付け / 報酬系 / 実行機能 / 覚醒 / 実行系 / 環境 / 脳・神経 / スポーツ科学 / 精神医学 / 心理学 / 教育学 / 脳活動 / ガンマオシレーション / 橋渡し研究 / 気分障害 / ペリニューロナルネット / 炎症免疫 / 脳波 / 神経免疫 / γオシレーション / 摂食障害 / 脳腸相関 / 糞便移植 / 神経性やせ症 / 腸内フローラ / 神経炎症 / 神経性無食欲症 / 分子神経免疫 / 自閉スペクトラム症 / 小脳機能 / 協調運動 / 感覚統合 / 事象関連電位 / 近赤外線スペクトロスコピィ / 協調運動障害 / 小脳構造 / 社会的ひきこもり / オリゴデンドロサイト / 新型うつ / 栄養 / 脳内炎症 / グリア / うつ病 / 炎症 / 免疫 / 神経発達 / 社会集団での行動解析 / ストレス / 幼児虐待 / Hikikomori / 化学遺伝学 / 社会集団での行動表現型 Less

小児期栄養環境が形づくる髄鞘構造とその精神症状への効果の検討Principal InvestigatorOngoing
- Principal Investigator
  
  牧之段学
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Nara Medical University
幼少期社会的経験が形づくる前頭前野-視床回路の同定Principal InvestigatorOngoing
- Principal Investigator
  
  牧之段学
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Nara Medical University
Understanding the neural mechanisms of effects of early life environments on brain and behavior by using new behavioral analysis systemOngoing
- Principal Investigator
  
  西真弓
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 51020:Cognitive and brain science-related
- Research Institution
  Nara Medical University
多次元解析による神経性無食欲症のサイコバイオティクスの同定：治療薬の創発に向けてOngoing
- Principal Investigator
  
  岸本年史
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Nara Medical University
小脳構造と協調運動および自閉スペクトラム症諸症状との相関解析Ongoing
- Principal Investigator
  
  飯田順三
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  Nara Medical University
Creation and Promotion of WilldynamicsOngoing
- Principal Investigator
  
  桜井武
- Project Period (FY)
  2016 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  University of Tsukuba
Clarifying the underlying mechanisms of schizophrenia focusing on the abnormalities of neuronal activities and immune responses.
- Principal Investigator
  
  kanba Shigenobu
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Psychiatric science
- Research Institution
  Kyushu University
自閉スペクトラム症における前頭前野機能の多面的解析とその正常化への試みPrincipal InvestigatorOngoing
- Principal Investigator
  
  牧之段学
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Psychiatric science
- Research Institution
  Nara Medical University
神経グリア発達によるモチベーションの形成とその破綻・修復機構の解明Ongoing
- Principal Investigator
  
  加藤隆弘
- Project Period (FY)
  2016 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Kyushu University
Social experience-dependent myelination in the mPFC and its relevant synapse formationPrincipal Investigator
- Principal Investigator
  
  Makinodan Manabu
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Psychiatric science
- Research Institution
  Nara Medical University
The research of social experience-dependent development of prefrontal excitatory neural circuit for psychiatric treatment
- Principal Investigator
  
  Yoshino Hiroki
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  Nara Medical University
The effects of immature cells in the hypothalamus on food intake and weight gain
- Principal Investigator
  
  INOUE Yuichirou
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  Nara Medical University
Multilateral analysis of Neuregulin-1 function in schizophrenia patients.
- Principal Investigator
  
  KISHIMOTO Toshifumi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  Nara Medical University
Investigation about the treatment of autism spectrum disorder using Animal model for autism.
- Principal Investigator
  
  SADAMATSU Miyuki
- Project Period (FY)
  2007 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  Nara Medical University

All 2019 2018 2017 2016 2010 Other

All Journal Article Presentation

[Journal Article] Characterization of behavioral phenotypes in the BTBR T+ Itpr3tf/J mouse model of autism spectrum disorder under social housing conditions using the multiple animal positioning system2019
- Author(s)
 Endo N, Makinodan M*, Somayama N, Komori T, Kishimoto T, Nishi M*
- Journal Title
 
 Experimental Animals
 
 Volume: Epub ahead of print Issue: 3 Pages: 1-1
- DOI
 10.1538/expanim.18-0177
- NAID
 130007689880
- ISSN
 1341-1357, 1881-7122
- Language
 English
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-17K19922, KAKENHI-PROJECT-16H05377, KAKENHI-PROJECT-17H07032
[Journal Article] Effects of the mode of re-socialization after juvenile social isolation on medial prefrontal cortex myelination and function.2018
- Author(s)
  Makinodan M. Ikawa D. Yamamuro K. Yamashita Y. Torituka M. Kimoto S. Okumura K. Komori T. Fukami S. Yoshino H. Kanba S. Wanaka A. Kishimoto T
- Journal Title
  
  Scientific Reports
  
  Volume: 14 Pages: 5481-5481
- DOI
  10.1038/s41598-017-05632-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10339, KAKENHI-PROJECT-15K15432, KAKENHI-PROJECT-16H05377, KAKENHI-PROJECT-15K14354
[Journal Article] Multiple animal positioning system shows that socially-reared mice influence the social proximity of isolation-reared cagemates2018
- Author(s)
  Endo N, Ujita W, Fujiwara T, Miyauchi H, Mishima H, Makino Y, Hashimoto L, Oyama, H, Makinodan M, Nishi M, Tohyama C, Kakeyama M*
- Journal Title
  
  Commun Biol
  
  Volume: 1 Pages: 225-225
- DOI
  10.1038/s42003-018-0213-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K19922, KAKENHI-PROJECT-16H05377, KAKENHI-PROJECT-17H07032
[Journal Article] Altered gene expression in lymphoblastoid cell lines after subculture.2018
- Author(s)
  Toritsuka M, Makinodan M, Yamauchi T, Yamashita Y, Ikawa D, Komori T, Kimoto S, Hamano-Iwasa K, Matsuzaki H, Kishimoto T.
- Journal Title
  
  In Vitro Cell Dev Biol Anim
  
  Volume: 54 Pages: 523-527
- DOI
  10.1007/s11626-018-0267-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05373, KAKENHI-PROJECT-16H05377
[Journal Article] Social isolation during the critical period reduces synaptic and intrinsic excitability of a subtype of prefrontal cortex pyramidal cell2018
- Author(s)
  Yamamuro K, Yoshino H, Ogawa Y, Makinodan M, Toritsuka M, Yamashita M, Corfas G, Kishimoto T.
- Journal Title
  
  Cereb Cortex
  
  Volume: 1-13 Pages: 998-1010
- DOI
  10.1093/cercor/bhx010
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-16H06400, KAKENHI-PROJECT-16K10221, KAKENHI-PROJECT-15K15432
[Journal Article] Distinct patterns of blood oxygenation in the prefrontal cortex in clinical phenotyoes of schizophrenia and bipolar disorders2018
- Author(s)
  Yamamuro K. Kimoto S. Iida J. Kishimoto N. Tanaka S. Ota T. Makinodan M.
- Journal Title
  
  J Afffect Disord
  
  Volume: 234 Pages: 45-53
- DOI
  10.1016/j.jad.2018.02.065
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10339
[Journal Article] Effects of cross-rearing with social peers on myelination in the medial prefrontal cortex of a mouse model with autism spectrum disorder.2017
- Author(s)
  Makinodan M. Okumura K. Ikawa D. Yamashita Y. Yamamuro K. Toritsuka M. Kimoto S. Yamauchi T. Komori T. Kayashima Y. Yoshino H. Wanaka A. Kishimoto T.
- Journal Title
  
  Heliyon
  
  Volume: 3
- DOI
  10.1016/j.heliyon.2017.e00468
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10339, KAKENHI-PROJECT-16H05377, KAKENHI-PROJECT-15K14354
[Journal Article] Tumor necrosis factor-alpha expression in peripheral blood mononuclear cells correlates with early childhood social interaction in autism spectrum disorder2017
- Author(s)
  Makinodan M, Iwata K, Ikawa D, Yamashita Y, Yamamuro K, Toritsuka M, Kimoto S, Okumura K, Yamauchi T, Yoshino H, Tsujii M, Sugiyama T, Tsuchiya K, Mori N, Matsuzaki H, Kishimoto T.
- Journal Title
  
  Neurochem Int
  
  Volume: 104 Pages: 1-5
- DOI
  10.1016/j.neuint.2016.12.005
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-16H06400, KAKENHI-PROJECT-16H05373, KAKENHI-PROJECT-15K15425, KAKENHI-PROJECT-26670351
[Journal Article] Microglia-derived neuregulin expression in psychiatric disorders2017
- Author(s)
  Ikawa D, Makinodan M, Iwata K, Ohgidani M, Kato TA, Yamashita Y, Yamamuro K, Kimoto S, Toritsuka M, Yamauchi T, Fukami SI, Yoshino H, Okumura K, Tanaka T, Wanaka A, Owada Y, Tsujii M, Sugiyama T, Tsuchiya K, Mori N, Hashimoto R, Matsuzaki H, Kanba S, Kishimoto T.
- Journal Title
  
  Brain, Behavior, and Immunity
  
  Volume: 61 Pages: 375-385
- DOI
  10.1016/j.bbi.2017.01.003
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-ORGANIZER-16H06400, KAKENHI-PROJECT-16H05116, KAKENHI-PROJECT-16H05373, KAKENHI-PROJECT-16H05375, KAKENHI-PROJECT-26293039, KAKENHI-PROJECT-26350122, KAKENHI-PROJECT-15K15425, KAKENHI-PROJECT-15K19743, KAKENHI-PROJECT-16K12735, KAKENHI-PROJECT-15K14354
[Journal Article] Social isolation impairs remyelination in mice through modulation of interleukin-6.2016
- Author(s)
  Makinodan M, Ikawa D, Miyamoto Y, Yamauchi J, Yamamuro K, Yamashita Y, Toritsuka M, Kimoto S, Okumura K, Yamauchi T, Fukami SI, Yoshino H, Wanaka A, Kishimoto T.
- Journal Title
  
  FASEB. J.
  
  Volume: 30 Pages: 4267-4274
- DOI
  10.1096/fj.201600537r
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-16H06400, KAKENHI-PROJECT-26830054
[Journal Article] Olanzapine increaes cell mitotic activity and oligodendrocyte-lineage cells in the hypothalamus2010
- Author(s)
  Takahira Yamauchi, Kouko Tatsumi, Manabu Makinodan, Souhei Kimoto, Michihiro Toritsuka, Hiroaki Okuda, Toshifumi Kishimoto, Akio Wanaka
- Journal Title
  
  Neurochemistry International
  
  Volume: 57 Pages: 565-571
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591490
[Presentation] 自殺と脳科学2018
- Author(s)
  牧之段学
- Organizer
  日本自殺予防学会
- Invited
- Data Source
  KAKENHI-PROJECT-15K15432
[Presentation] 自殺と脳科学2018
- Author(s)
  牧之段学
- Organizer
  日本自殺予防学会
- Data Source
  KAKENHI-PROJECT-16H05377
[Presentation] 自閉スペクトラム症の免疫異常とミエリン形成障害2018
- Author(s)
  牧之段学
- Organizer
  日本生物学的精神医学会
- Data Source
  KAKENHI-PROJECT-15K15432
[Presentation] 幼少期社会的経験と前頭前野2018
- Author(s)
  牧之段学
- Organizer
  日本生物学的精神医学会・日本神経化学会合同年会
- Data Source
  KAKENHI-PROJECT-16H05377
[Presentation] 自閉スペクトラム症の免疫異常とミエリン形成障害2018
- Author(s)
  牧之段学
- Organizer
  日本生物学的精神医学会・日本神経化学会合同年会
- Data Source
  KAKENHI-PROJECT-16H05377
[Presentation] マイクログリア由来神経栄養因子と自閉スペクトラム症2017
- Author(s)
  牧之段学
- Organizer
  日本生物学的精神医学会・日本神経精神薬理学会合同年会
- Data Source
  KAKENHI-PROJECT-17K10339
[Presentation] マイクログリア由来神経栄養因子と自閉スペクトラム症2017
- Author(s)
  牧之段学
- Organizer
  日本生物学的精神医学会・日本神経精神薬理学会合同年会
- Data Source
  KAKENHI-PROJECT-15K15432
[Presentation] Shared glial contributions to the etiology of autism and schizophrenia2017
- Author(s)
  Makinodan M.
- Organizer
  World Congress of Biological Psychiatry
- Data Source
  KAKENHI-PROJECT-17K10339
[Presentation] 日本人研究者による自閉スペクトラム症の生物学的研究2017
- Author(s)
  牧之段学
- Organizer
  日本児童青年精神医学会総会
- Data Source
  KAKENHI-PROJECT-16H05377
[Presentation] Shared glial contributions to the etiology of autism and schizophrenia.2017
- Author(s)
  Manabu Makinodan
- Organizer
  World Congress of Biological Psychiatry
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15432
[Presentation] Shared glial contributions to the etiology of autism and schizophrenia.2017
- Author(s)
  Makinodan M
- Organizer
  World Congress of Biological Psychiatry
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05377
[Presentation] 日本人研究者による自閉スペクトラム症の生物学的研究2017
- Author(s)
  牧之段学
- Organizer
  第58回日本児童青年精神医学会
- Data Source
  KAKENHI-PROJECT-17K10339
[Presentation] 髄鞘化による前頭前野機能発達と精神疾患2016
- Author(s)
  牧之段学
- Organizer
  日本神経化学・日本生物精神合同年会シンポジウム
- Place of Presentation
  福岡市
- Year and Date
  2016-09-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15432
[Presentation] Glial implications in E/I balance in autism.2016
- Author(s)
  Manabu Makinodan
- Organizer
  WFSBP2016
- Place of Presentation
  Lima, Peru
- Year and Date
  2016-11-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15432
[Presentation] 社会的孤立によるマウス内側前頭前皮質の興奮性シナプス伝達の減弱
- Author(s)
  山室　和彦、芳野　浩樹、小川　陽一、牧之段　学、岸本　年史
- Organizer
  第36回日本生物学的精神学会　第57回日本神経化学会大会　合同年会
- Place of Presentation
  奈良
- Year and Date
  2014-09-29 – 2014-10-01
- Data Source
  KAKENHI-PROJECT-25461778
[Presentation] Chronic social isolation reduces excitatory synaptic inputs in medial prefrontal cortex
- Author(s)
  K. Yamamuro, H.Yoshino, Y. Ogawa, M. Makinodan, C.Gabriel, T. Kishimoto
- Organizer
  44th Annual meeting of Society for neuroscience
- Place of Presentation
  Washington DC USA
- Year and Date
  2014-11-15 – 2014-11-19
- Data Source
  KAKENHI-PROJECT-25461778

1. Yoshino Hiroki (10347560)

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38. 松田康裕 (70445063)

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39. 宮坂俊輝 (00771023)

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40. 北村聡一郎 (10714389)

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41. 矢野寿一 (20374944)

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42. 松岡究 (80613794)

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Makinodan Manabu 牧之段 学

MAKINODAN Manabu 牧之段 学

Research Projects

Research Products

Co-Researchers

小児期栄養環境が形づくる髄鞘構造とその精神症状への効果の検討Principal InvestigatorOngoing

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幼少期社会的経験が形づくる前頭前野-視床回路の同定Principal InvestigatorOngoing

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Understanding the neural mechanisms of effects of early life environments on brain and behavior by using new behavioral analysis systemOngoing

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多次元解析による神経性無食欲症のサイコバイオティクスの同定：治療薬の創発に向けてOngoing

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小脳構造と協調運動および自閉スペクトラム症諸症状との相関解析Ongoing

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Creation and Promotion of WilldynamicsOngoing

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Clarifying the underlying mechanisms of schizophrenia focusing on the abnormalities of neuronal activities and immune responses.

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自閉スペクトラム症における前頭前野機能の多面的解析とその正常化への試みPrincipal InvestigatorOngoing

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神経グリア発達によるモチベーションの形成とその破綻・修復機構の解明Ongoing

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Social experience-dependent myelination in the mPFC and its relevant synapse formationPrincipal Investigator

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The research of social experience-dependent development of prefrontal excitatory neural circuit for psychiatric treatment

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The effects of immature cells in the hypothalamus on food intake and weight gain

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Multilateral analysis of Neuregulin-1 function in schizophrenia patients.

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Makinodan Manabu 牧之段学

MAKINODAN Manabu 牧之段学