Makinodan Manabu 牧之段学

… Alternative Names

Researcher Number	00510182
Affiliation (Current)	2019: 奈良県立医科大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2015 – 2019: 奈良県立医科大学, 医学部, 講師 2015: 奈良県立医科大学, 医学部, 助教 2010 – 2011: 奈良県立医科大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Psychiatric science / Biological Sciences Except Principal Investigator Psychiatric science / Complex systems / Basic Section 52030:Psychiatry-related / Basic Section 51020:Cognitive and brain science-related
Keywords	Principal Investigator 前頭前野 / 自閉スペクトラム症 / 自閉症 / 幼少期社会的経験 / 隔離飼育 / ミエリン / 恐怖記憶 / 視床 / 海馬 / 認知リハビリテーション … More Except Principal Investigator 統合失調症 / ひきこもり / 現代うつ / モチベーション / ミクログリア / モデルマウス / 神経免疫 / γオシレーション / 行動解析 / 体重増加 / ニューレグリン / やる気 / 心理学 / 小脳構造 / オランザピン / オリゴデンドロサイト / 協調運動 / 錐体細胞 / ガラニン / 小脳機能 / スポーツ科学 / トランスレーショナルリサーチ / 協調運動障害 / 末梢神経伝道速度 / 内側前頭前野 / 神経炎症 / 自閉症 / 興奮性 / 神経性無食欲症 / 分子神経免疫 / 末梢神経伝導速度 / ストレス / 前頭前野 / 興奮性シナプス伝達 / 幼児虐待 / 社会的経験 / 社会集団での行動表現型 / 神経発達 / 脳波 / 感覚統合 / 実行機能 / 化学遺伝学 / ガンマオシレーション / 社会的ひきこもり / Hikikomori / 意志力 / 脂肪細胞 / iPS細胞 / ペリニューロナルネット / 実行系 / 神経細胞 / 膜興奮性 / 教育学 / カテコールアミン / 発達 / 前頭葉 / 脳・神経 / 精神医学 / 環境 / グリア / 小脳 / 覚醒 / 報酬系 / うつ病 / 社会的隔離 / 神経性やせ症 / h-current / セロトニン / 脳機能 / 甲状腺ホルモン / 炎症免疫 / 自閉スペクトラム症 / 社会経験 / 興奮性後シナプス電流 / 脳腸相関 / ノックアウトマウス / 腸内フローラ / Olig2 / 拡散テンソル画像 Less

幼少期社会的経験が形づくる前頭前野-視床回路の同定Principal InvestigatorOngoing
- Principal Investigator
  
  牧之段学
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Nara Medical University
Understanding the neural mechanisms of effects of early life environments on brain and behavior by using new behavioral analysis systemOngoing
- Principal Investigator
  
  西真弓
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 51020:Cognitive and brain science-related
- Research Institution
  Nara Medical University
多次元解析による神経性無食欲症のサイコバイオティクスの同定：治療薬の創発に向けてOngoing
- Principal Investigator
  
  岸本年史
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Nara Medical University
小脳構造と協調運動および自閉スペクトラム症諸症状との相関解析Ongoing
- Principal Investigator
  
  飯田順三
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  Nara Medical University
神経グリア発達によるモチベーションの形成とその破綻・修復機構の解明Ongoing
- Principal Investigator
  
  加藤隆弘
- Project Period (FY)
  2016 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Kyushu University
統合失調症の神経活動異常と神経免疫異常：相互メカニズムの解明に向けてOngoing
- Principal Investigator
  
  神庭重信
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Psychiatric science
- Research Institution
  Kyushu University
Creation and Promotion of WilldynamicsOngoing
- Principal Investigator
  
  桜井武
- Project Period (FY)
  2016 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  University of Tsukuba
自閉スペクトラム症における前頭前野機能の多面的解析とその正常化への試みPrincipal InvestigatorOngoing
- Principal Investigator
  
  牧之段学
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Psychiatric science
- Research Institution
  Nara Medical University
社会的経験依存性前頭前野ミエリン形成と同部位シナプス形成との相関についての検証Principal InvestigatorOngoing
- Principal Investigator
  
  牧之段学
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Psychiatric science
- Research Institution
  Nara Medical University
The research of social experience-dependent development of prefrontal excitatory neural circuit for psychiatric treatment
- Principal Investigator
  
  Yoshino Hiroki
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  Nara Medical University
The effects of immature cells in the hypothalamus on food intake and weight gain
- Principal Investigator
  
  INOUE Yuichirou
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  Nara Medical University
Multilateral analysis of Neuregulin-1 function in schizophrenia patients.
- Principal Investigator
  
  KISHIMOTO Toshifumi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  Nara Medical University
Investigation about the treatment of autism spectrum disorder using Animal model for autism.
- Principal Investigator
  
  SADAMATSU Miyuki
- Project Period (FY)
  2007 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  Nara Medical University

All 2018 2017 2016 2010 Other

All Journal Article Presentation

[Journal Article] Social isolation during the critical period reduces synaptic and intrinsic excitability of a subtype of prefrontal cortex pyramidal cell2018
- Author(s)
  Yamamuro K, Yoshino H, Ogawa Y, Makinodan M, Toritsuka M, Yamashita M, Corfas G, Kishimoto T
- Journal Title
  
  Cerebral Cortex
  
  Volume: 28 Pages: 998-1010
- DOI
  10.1093/cercor/bhx010
- Open Access / Acknowledgement Compliant / Int'l Joint Research / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K15432, KAKENHI-ORGANIZER-16H06400, KAKENHI-PROJECT-16K10221
[Journal Article] Effects of the mode of re-socialization after juvenile social isolation on medial prefrontal cortex myelination and function2018
- Author(s)
  Makinodan M, Ikawa D, Yamamuro K, Yamashita Y, Toritsuka M, Kimoto S, Yamauchi T, Okumura K, Komori T, Fukami SI, Yoshino H, Kanba S, Wanaka A, Kishimoto T.
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Pages: 5481-5481
- DOI
  10.1038/s41598-017-05632-2
- Open Access / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05377, KAKENHI-PROJECT-17K10339, KAKENHI-PROJECT-15K15432, KAKENHI-PROJECT-15K14354
[Journal Article] Microglia-derived neuregulin expression in psychiatric disorders2017
- Author(s)
  Ikawa D, Makinodan M, Iwata K, Ohgidani M, Kato TA, Yamashita Y, Yamamuro K, Kimoto S, Toritsuka M, Yamauchi T, Fukami SI, Yoshino H, Okumura K, Tanaka T, Wanaka A, Owada Y, Tsujii M, Sugiyama T, Tsuchiya K, Mori N, Hashimoto R, Matsuzaki H, Kanba S, Kishimoto T.
- Journal Title
  
  Brain, Behavior, and Immunity
  
  Volume: 61 Pages: 375-385
- DOI
  10.1016/j.bbi.2017.01.003
- Open Access / Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-16H06400, KAKENHI-PROJECT-16H05116, KAKENHI-PROJECT-16H05373, KAKENHI-PROJECT-16H05375, KAKENHI-PROJECT-26293039, KAKENHI-PROJECT-26350122, KAKENHI-PROJECT-15K15425, KAKENHI-PROJECT-15K19743, KAKENHI-PROJECT-16K12735, KAKENHI-PROJECT-15K14354
[Journal Article] Effects of cross-rearing with social peers on myelination in the medial prefrontal cortex of a mouse model with autism spectrum disorder.2017
- Author(s)
  Makinodan M. Okumura K. Ikawa D. Yamashita Y. Yamamuro K. Toritsuka M. Kimoto S. Yamauchi T. Komori T. Kayashima Y. Yoshino H. Wanaka A. Kishimoto T.
- Journal Title
  
  Heliyon
  
  Volume: 3
- DOI
  10.1016/j.heliyon.2017.e00468
- Open Access / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10339, KAKENHI-PROJECT-16H05377, KAKENHI-PROJECT-15K14354
[Journal Article] Tumor necrosis factor-alpha expression in peripheral blood mononuclear cells correlates with early childhood social interaction in autism spectrum disorder2017
- Author(s)
  Makinodan M, Iwata K, Ikawa D, Yamashita Y, Yamamuro K, Toritsuka M, Kimoto S, Okumura K, Yamauchi T, Yoshino H, Tsujii M, Sugiyama T, Tsuchiya K, Mori N, Matsuzaki H, Kishimoto T.
- Journal Title
  
  Neurochem Int
  
  Volume: 104 Pages: 1-5
- DOI
  10.1016/j.neuint.2016.12.005
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-16H06400, KAKENHI-PROJECT-16H05373, KAKENHI-PROJECT-15K15425, KAKENHI-PROJECT-26670351
[Journal Article] Social isolation impairs remyelination in mice through modulation of interleukin-6.2016
- Author(s)
  Makinodan M, Ikawa D, Miyamoto Y, Yamauchi J, Yamamuro K, Yamashita Y, Toritsuka M, Kimoto S, Okumura K, Yamauchi T, Fukami SI, Yoshino H, Wanaka A, Kishimoto T.
- Journal Title
  
  FASEB. J.
  
  Volume: 30 Pages: 4267-4274
- DOI
  10.1096/fj.201600537r
- Open Access / Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-16H06400, KAKENHI-PROJECT-26830054
[Journal Article] Olanzapine increaes cell mitotic activity and oligodendrocyte-lineage cells in the hypothalamus2010
- Author(s)
  Takahira Yamauchi, Kouko Tatsumi, Manabu Makinodan, Souhei Kimoto, Michihiro Toritsuka, Hiroaki Okuda, Toshifumi Kishimoto, Akio Wanaka
- Journal Title
  
  Neurochemistry International
  
  Volume: 57 Pages: 565-571
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591490
[Presentation] 日本人研究者による自閉スペクトラム症の生物学的研究2017
- Author(s)
  牧之段学
- Organizer
  第58回日本児童青年精神医学会
- Data Source
  KAKENHI-PROJECT-17K10339
[Presentation] Shared glial contributions to the etiology of autism and schizophrenia.2017
- Author(s)
  Makinodan M
- Organizer
  World Congress of Biological Psychiatry
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05377
[Presentation] Shared glial contributions to the etiology of autism and schizophrenia2017
- Author(s)
  Makinodan M.
- Organizer
  World Congress of Biological Psychiatry
- Data Source
  KAKENHI-PROJECT-17K10339
[Presentation] マイクログリア由来神経栄養因子と自閉スペクトラム症2017
- Author(s)
  牧之段学
- Organizer
  日本生物学的精神医学会・日本神経精神薬理学会合同年会
- Data Source
  KAKENHI-PROJECT-15K15432
[Presentation] 日本人研究者による自閉スペクトラム症の生物学的研究2017
- Author(s)
  牧之段学
- Organizer
  日本児童青年精神医学会総会
- Data Source
  KAKENHI-PROJECT-16H05377
[Presentation] マイクログリア由来神経栄養因子と自閉スペクトラム症2017
- Author(s)
  牧之段学
- Organizer
  日本生物学的精神医学会・日本神経精神薬理学会合同年会
- Data Source
  KAKENHI-PROJECT-17K10339
[Presentation] Shared glial contributions to the etiology of autism and schizophrenia.2017
- Author(s)
  Manabu Makinodan
- Organizer
  World Congress of Biological Psychiatry
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15432
[Presentation] Glial implications in E/I balance in autism.2016
- Author(s)
  Manabu Makinodan
- Organizer
  WFSBP2016
- Place of Presentation
  Lima, Peru
- Year and Date
  2016-11-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15432
[Presentation] 髄鞘化による前頭前野機能発達と精神疾患2016
- Author(s)
  牧之段学
- Organizer
  日本神経化学・日本生物精神合同年会シンポジウム
- Place of Presentation
  福岡市
- Year and Date
  2016-09-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15432
[Presentation] 社会的孤立によるマウス内側前頭前皮質の興奮性シナプス伝達の減弱
- Author(s)
  山室　和彦、芳野　浩樹、小川　陽一、牧之段　学、岸本　年史
- Organizer
  第36回日本生物学的精神学会　第57回日本神経化学会大会　合同年会
- Place of Presentation
  奈良
- Year and Date
  2014-09-29 – 2014-10-01
- Data Source
  KAKENHI-PROJECT-25461778
[Presentation] Chronic social isolation reduces excitatory synaptic inputs in medial prefrontal cortex
- Author(s)
  K. Yamamuro, H.Yoshino, Y. Ogawa, M. Makinodan, C.Gabriel, T. Kishimoto
- Organizer
  44th Annual meeting of Society for neuroscience
- Place of Presentation
  Washington DC USA
- Year and Date
  2014-11-15 – 2014-11-19
- Data Source
  KAKENHI-PROJECT-25461778

1. Yoshino Hiroki (10347560)

# of Collaborated Projects: 3 results

# of Collaborated Products: 5 results
2. 紀本創兵 (00405391)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
3. 太田豊作 (10553646)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. SADAMATSU Miyuki (90252387)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. YAMAUCHI Takahira (20550817)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
6. KISHIMOTO Toshifumi (60201456)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. 加藤隆弘 (70546465)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
8. 井川大輔 (00526717)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
9. 安野史彦 (60373388)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. KANAI Hirohiko (30293830)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. INOUE Yuichirou (40326343)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. NORIYAMA Yoshinobu (20305725)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. KIUCHI Kuniaki (20398449)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. TAOKA Toshiaki (30305734)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. TSUBOI Akio (20163868)

# of Collaborated Projects: 1 results

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16. 境泉洋 (90399220)

# of Collaborated Projects: 1 results

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17. 黒川清 (40215083)

# of Collaborated Projects: 1 results

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18. 深見伸一 (90424150)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
19. 神庭重信 (50195187)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 桜井武 (60251055)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 田中あゆみ (00373085)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
22. 浅川明弘 (10452947)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 尾内康臣 (40436978)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 征矢英昭 (50221346)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 藤原広臨 (10599608)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 佐久間英輔 (90295585)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 杉原玄一 (70402261)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. 井上浩一 (80345818)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. 鈴木高志 (90725938)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. 乾明夫 (80168418)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. 須藤信行 (60304812)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. 榊美知子 (50748671)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. 植木美乃 (40467478)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
34. 入鹿山容子 (90312834)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
35. 犬束歩 (30584776)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
36. 杉山陽子 (00317512)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
37. 松田康裕 (70445063)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
38. 宮坂俊輝 (00771023)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
39. 北村聡一郎 (10714389)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
40. 矢野寿一 (20374944)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
41. 鳥塚通弘 (20588529)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
42. 松岡究 (80613794)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
43. 飯田順三 (50159555)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
44. 山室和彦 (60526721)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
45. 岩坂英巳 (70244712)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
46. 西真弓 (40295639)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
47. 遠藤のぞみ (90802819)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
48. 大和田祐二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
49. 松崎秀夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
50. 松崎伸介

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
51. 橋本亮太

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
52. 和中明生

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
53. 岩田圭子

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
54. 宮本幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
55. 杉山登志朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
56. 森友久

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Makinodan Manabu 牧之段 学

MAKINODAN Manabu 牧之段 学

Research Projects

Research Products

Co-Researchers

幼少期社会的経験が形づくる前頭前野-視床回路の同定Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Understanding the neural mechanisms of effects of early life environments on brain and behavior by using new behavioral analysis systemOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

多次元解析による神経性無食欲症のサイコバイオティクスの同定：治療薬の創発に向けてOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

小脳構造と協調運動および自閉スペクトラム症諸症状との相関解析Ongoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

神経グリア発達によるモチベーションの形成とその破綻・修復機構の解明Ongoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

統合失調症の神経活動異常と神経免疫異常：相互メカニズムの解明に向けてOngoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Creation and Promotion of WilldynamicsOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

自閉スペクトラム症における前頭前野機能の多面的解析とその正常化への試みPrincipal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

社会的経験依存性前頭前野ミエリン形成と同部位シナプス形成との相関についての検証Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The research of social experience-dependent development of prefrontal excitatory neural circuit for psychiatric treatment

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The effects of immature cells in the hypothalamus on food intake and weight gain

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Multilateral analysis of Neuregulin-1 function in schizophrenia patients.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation about the treatment of autism spectrum disorder using Animal model for autism.

Principal Investigator

Project Period (FY)

Makinodan Manabu 牧之段学

MAKINODAN Manabu 牧之段学