Sakaguchi Hirofumi 坂口博史

… Alternative Names

SAKAGUCHI Hirofumi 坂口博史

Less

Researcher Number	00515223
Affiliation (Current)	2025: 神戸大学, バイオシグナル総合研究センター, 研究員
Affiliation (based on the past Project Information) *help	2019 – 2024: 神戸大学, バイオシグナル総合研究センター, 研究員 2013 – 2019: 京都府立医科大学, 医学(系)研究科(研究院), 准教授 2010 – 2012: 京都府立医科大学, 医学(系)研究科(研究院), 講師 2009 – 2011: Kyoto Prefectural University of Medicine, 医学研究科, 助教
Review Section/Research Field	Principal Investigator Otorhinolaryngology / Basic Section 56050:Otorhinolaryngology-related Except Principal Investigator Basic Section 48030:Pharmacology-related / General medical chemistry / Medium-sized Section 46:Neuroscience and related fields / General pharmacology
Keywords	Principal Investigator 有毛細胞 / 内耳 / 聴覚 / 難聴 / 蝸牛 / 遺伝性難聴 / 遺伝子導入 / ゲノム編集 / 遺伝子治療 / 遺伝子 … More / muscular dystrophy / nox3 / dia1 / hearing / inner ear / 内リンパ電位 / 感音難聴 / tricellulin / イオン / トリセルリン / 内リンパ / タイト結合 / 支持細胞 / アメリカ / 国際情報交換 / 細胞間結合 / II型ミオシン / アクチン / 頂側結合 / サルコメア / 上皮細胞 / ミオシン / 機械電気変換 / 再生 / 不動毛 / tip lin / protocadherin / cadherin 23 / カドヘリン / tip link … More Except Principal Investigator 活性酸素 / 聴覚 / ROS / 難聴 / DIAPH1 / 遺伝性難聴 / 感音難聴 / DFNA1 / DIA1 / 活性酸素種 / 平衡覚 / NADPH oxidase / 後天性難聴 / 後天性感音難聴 / 左右差 / 視覚 / 視聴覚 / ＤＩＡ１ / 遺伝 / 血液異常 / 進行性難聴 / 聴力 / 内耳有毛細胞 / Rac / Rho-family GTPase / アクチン / RhoA / Cdc42 / 耳石 / 聴毛 / 低分子量G蛋白質 / 内耳 / balancing / hearing / inner ear / small GTPases Less

活性酸素産生酵素NOX3の発現制御機序解明による後天性及び片側性難聴の治療法開発
- Principal Investigator
  
  上山健彦
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 48030:Pharmacology-related
- Research Institution
  Kobe University
Elucidation of acquired SNHL mechanism caused from Nox3-derived ROS and beyond
- Principal Investigator
  
  Ueyama Takehiko
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 48030:Pharmacology-related
- Research Institution
  Kobe University
Challenge for establishing the criteria of laterality-based diseases in hearing and vision
- Principal Investigator
  
  Ueyama Takehiko
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 46:Neuroscience and related fields
- Research Institution
  Kobe University
Investigation for gene transfer therapy in inner earsPrincipal Investigator
- Principal Investigator
  
  SAKAGUCHI HIROFUMI
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Kobe University
  Kyoto Prefectural University of Medicine
Mechanism clarification of new symptoms in DFNA1 causing from constitutively active DAI1 mutants
- Principal Investigator
  
  Ueyama Takehiko
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Kobe University
Roles of Rho-family small GTPases in establishment and maintenance for hearing and balancing
- Principal Investigator
  
  Ueyama Takehiko
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Kobe University
Role of apical junctions in barrier function and structural maintenance of the cochlear sensory epitheliaPrincipal Investigator
- Principal Investigator
  
  Sakaguchi Hirofumi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Kyoto Prefectural University of Medicine
Morphological regulation of the developmental inner ear hair cells by non-muscle myosin IIPrincipal Investigator
- Principal Investigator
  
  SAKAGUCHI Hirofumi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Kyoto Prefectural University of Medicine
Roles of small GTPases and ROS in functions anddiseases of inner ear
- Principal Investigator
  
  UEYAMA Takehiko
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Kobe University
Research in the metabolic dynamics of the molecular component of the tip link, essential structure for hearing receptionPrincipal Investigator
- Principal Investigator
  
  SAKAGUCHI Hirofumi
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Kyoto Prefectural University of Medicine

All 2023 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009

All Journal Article Presentation

[Journal Article] Dispensable role of Rac1 and Rac3 after cochlear hair cell specification2023
- Author(s)
  Nakamura Takashi, Sakaguchi Hirofumi, Mohri Hiroaki, Ninoyu Yuzuru, Goto Akihiro, Yamaguchi Taro, Hishikawa Yoshitaka, Matsuda Michiyuki, Saito Naoaki, Ueyama Takehiko
- Journal Title
  
  Journal of Molecular Medicine
  
  Volume: 101 Issue: 7 Pages: 843-854
- DOI
  10.1007/s00109-023-02317-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06738, KAKENHI-PUBLICLY-22H05496, KAKENHI-PROJECT-21H02672
[Journal Article] Nox3-derived superoxide in cochleae induces sensorineural hearing loss.2021
- Author(s)
  Mohri H, Ninoyu Y, Sakaguchi H, Hirano S, Saito N, Ueyama T
- Journal Title
  
  J. Neurosci.
  
  Volume: JN-RM-2672-20
- NAID
  120007097047
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09383
[Journal Article] Nox3-Derived Superoxide in Cochleae Induces Sensorineural Hearing Loss2021
- Author(s)
  Mohri Hiroaki、Ninoyu Yuzuru、Sakaguchi Hirofumi、Hirano Shigeru、Saito Naoaki、Ueyama Takehiko
- Journal Title
  
  The Journal of Neuroscience
  
  Volume: 41 Issue: 21 Pages: 4716-4731
- DOI
  10.1523/jneurosci.2672-20.2021
- NAID
  120007097047
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22472, KAKENHI-PROJECT-21H02672
[Journal Article] Congenital hearing impairment associated with peripheral cochlear nerve dysmyelination in glycosylation-deficient muscular dystrophy2020
- Author(s)
  Morioka Shigefumi、Sakaguchi Hirofumi、Mohri Hiroaki、Taniguchi-Ikeda Mariko、Kanagawa Motoi、Suzuki Toshiaki、Miyagoe-Suzuki Yuko、Toda Tatsushi、Saito Naoaki、Ueyama Takehiko
- Journal Title
  
  PLOS Genetics
  
  Volume: 16 Issue: 5 Pages: 1-28
- DOI
  10.1371/journal.pgen.1008826
- NAID
  120006863578
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22472, KAKENHI-PROJECT-20H00526, KAKENHI-PROJECT-18H02616, KAKENHI-PROJECT-18K07790, KAKENHI-PROJECT-18K09383, KAKENHI-PLANNED-17H06421, KAKENHI-PROJECT-19K07519
[Journal Article] The integrity of cochlear hair cells is established and maintained through the localization of Dia1 at apical junctional complexes and stereocilia2020
- Author(s)
  Ninoyu Yuzuru、Sakaguchi Hirofumi、Lin Chen、Suzuki Toshiaki、Hirano Shigeru、Hisa Yasuo、Saito Naoaki、Ueyama Takehiko
- Journal Title
  
  Cell Death & Disease
  
  Volume: 11 Issue: 7 Pages: 1-15
- DOI
  10.1038/s41419-020-02743-z
- NAID
  120006877483
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22472, KAKENHI-PROJECT-18K09383, KAKENHI-PROJECT-18K16851
[Journal Article] Hearing vulnerability after noise exposure in a mouse model of reactive oxygen species overproduction2018
- Author(s)
  Morioka Shigefumi、Sakaguchi Hirofumi、Yamaguchi Taro、Ninoyu Yuzuru、Mohri Hiroaki、Nakamura Takashi、Hisa Yasuo、Ogita Kiyokazu、Saito Naoaki、Ueyama Takehiko
- Journal Title
  
  Journal of Neurochemistry
  
  Volume: 146 Issue: 4 Pages: 459-473
- DOI
  10.1111/jnc.14451
- NAID
  120006545101
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H04032, KAKENHI-PROJECT-17H04042, KAKENHI-PROJECT-16K08288
[Journal Article] Novel role of Rac-Mid1 signaling in medial cerebellar development.2017
- Author(s)
  Nakamura T, Ueyama T, Ninoyu Y, Sakaguchi H, Choijookhuu N, Hishikawa Y, Kiyonari H, Kohta M, Sakahara M, de Curtis I, Kohmura E, Hisa Y, Aiba A, Saito N.
- Journal Title
  
  Development
  
  Volume: 144 Issue: 10 Pages: 1863-1875
- DOI
  10.1242/dev.147900
- NAID
  120006363303
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08471, KAKENHI-PLANNED-25115010, KAKENHI-PROJECT-17H04032, KAKENHI-PROJECT-17H04042
[Journal Article] 蝸牛における tricellulin の機能2016
- Author(s)
  坂口博史, 神谷透, 宮下武憲, 稲本隆平, 徳増玲太郎, 森望, 月田早智子, 久育男
- Journal Title
  
  耳鼻咽喉科ニューロサイエンス
  
  Volume: 30 Pages: 8-12
- Data Source
  KAKENHI-PROJECT-26462563
[Journal Article] Constitutive activation of DIA1 (DIAPH1) via C-terminal truncation causes human sensorineural hearing loss.2016
- Author(s)
  Ueyama T, Ninoyu Y, Nishio S, Miyoshi T, Torii H, Nishimura K, Sugahara K, Sakata H, Thumkeo D, Sakaguchi H, Watanabe N, Usami S, Saito N, Kitajiri S.
- Journal Title
  
  EMBO Molecular Medicine
  
  Volume: 8 Issue: 11 Pages: 1310-1324
- DOI
  10.15252/emmm.201606609
- NAID
  120005850206
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02565, KAKENHI-PROJECT-16J09300, KAKENHI-PROJECT-26293369, KAKENHI-PROJECT-26460340, KAKENHI-PROJECT-15K10753
[Journal Article] Maintenance of stereocilia and apical junctional complexes by Cdc42 in cochlear hair cells2014
- Author(s)
  Ueyama T, Sakaguchi H, Nakamura T, Goto A, Morioka S, Shimizu A, Nakao K, Hishikawa Y, Ninoyu Y, Kassai H, Suetsugu S, Koji T, Fritzsch B, Yonemura S, Hisa Y, Matsuda M, Aiba A, Saito N.
- Journal Title
  
  J Cell Sci.
  
  Volume: 127 Pages: 2040-2052
- DOI
  10.1242/jcs.143602
- NAID
  120006986582
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24590255, KAKENHI-PUBLICLY-25113715, KAKENHI-PROJECT-25293060, KAKENHI-PROJECT-26291037, KAKENHI-PROJECT-26460340, KAKENHI-PROJECT-26670124
[Journal Article] NMII forms a contractile transcellular sarcomeric network to regulate apical cell junctions and tissue geometry2013
- Author(s)
  Ebrahim S, Fujita T, Millis BA, Kozin E, Ma X, Kawamoto S, Baird MA, Davidson M, Yonemura S, Hisa Y, Conti MA, Adelstein RS, Sakaguchi H, Kachar B
- Journal Title
  
  Curr Biol
  
  Volume: 23 Pages: 731-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592491
[Journal Article] 発生期蝸牛有毛細胞の形態変化とmyosin IIの関与2013
- Author(s)
  藤田朋己，坂口博史，米村重信，久　育男
- Journal Title
  
  耳鼻咽喉科ニューロサイエンス
  
  Volume: 27 Pages: 19-21
- Data Source
  KAKENHI-PROJECT-23592491
[Journal Article] 発生期蝸牛有毛細胞の形態変化とmyosin IIの関与2013
- Author(s)
  藤田朋己,坂口博史,米村重信,久育男
- Journal Title
  
  耳鼻咽喉科ニューロサイエンス
  
  Volume: 27 Pages: 19-21
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592491
[Journal Article] NMII Forms a Contractile Transcellular Sarcomeric Network to Regulate Apical Cell Junctions and Tissue Geometry.2013
- Author(s)
  Ebrahim S, Fujita T, Millis BA, Kozin E, Ma X, Kawamoto S, Baird MA, Davidson M, Yonemura S, Hisa Y, Conti MA, Adelstein RS, Sakaguchi H, Kachar B
- Journal Title
  
  Current Biology
  
  Volume: 23(8) Issue: 8 Pages: 731-6
- DOI
  10.1016/j.cub.2013.03.039
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592491
[Journal Article] Cooperation of p40^<phox> with p47^<phox> for Nox2 activation during Fc_γ R-mediated phagocytosis---Mechanism for acquisition of p40^<phox> PI(3)P binding---2011
- Author(s)
  Ueyama T, Nakakita N, Nakamura T, Kobayashi T, Kobayashi T, Son J, Sakuma M, Sakaguchi H, Leto TL, Saito N
- Journal Title
  
  J Biol.Chem.
  
  Volume: 286 Pages: 40693-40705
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590271
[Journal Article] 発生期コルチ器における頂側結合の経時的変化2010
- Author(s)
  藤田朋己, 瀧正勝, 坂口博史, ら
- Journal Title
  
  Otology Japan
  
  Volume: 2(4) Pages: 539-539
- Data Source
  KAKENHI-PROJECT-21791634
[Journal Article] 有毛細胞感覚糸(Tip Link)の再生と細胞頂側面形態形成への関与について2010
- Author(s)
  坂口博史
- Journal Title
  
  上原記念生命化学財団研究報告集
  
  Volume: 24 Pages: 155-155
- Data Source
  KAKENHI-PROJECT-21791634
[Journal Article] 発生期コルチ器における頂側結合の経時的変化2010
- Author(s)
  藤田朋己、瀧正勝、坂口博史、鈴木敏弘、米村重信、久育男
- Journal Title
  
  Otology Japan. 20(4)
  
  Pages: 539-539
- Data Source
  KAKENHI-PROJECT-21791634
[Journal Article] 有毛細胞感覚糸(Tip Link)の再生と細胞頂側面形態形成への関与について2010
- Author(s)
  坂口博史
- Journal Title
  
  上原記念生命化学財団研究報告集 24
  
  Pages: 155-155
- Data Source
  KAKENHI-PROJECT-21791634
[Journal Article] The Mechanotransduction machinery of hair cells.2009
- Author(s)
  Grillet N, Kazmierczak P, Xiong W, Shwander M, Reynolds A, Sakaguchi H, Tokita J, Kachar B, Muller U.
- Journal Title
  
  Sci Signal 2
  
  Pages: 5-5
- Data Source
  KAKENHI-PROJECT-21791634
[Journal Article] Tip links in hair cells : molecular composition and role in hearing loss.2009
- Author(s)
  Sakaguchi H, Tokita J, Muller U, Kachar B.
- Journal Title
  
  Curr Opin Otolaryngol Head Neck Surg 17
  
  Pages: 388-393
- Data Source
  KAKENHI-PROJECT-21791634
[Presentation] DFNA1疾患モデルマウスを用いたDIA1分子の局在と病態メカニズムの解2019
- Author(s)
  二之湯弦、坂口博史、陳林、毛利宏明、齋藤尚亮、上山健彦
- Organizer
  第60回日本組織細胞化学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-17H04042
[Presentation] 難聴を生み出す活性酸素発生源細胞の同定とその機能・障害メカニズムの解明2019
- Author(s)
  毛利宏明、二之湯弦、坂口博史、齋藤尚亮、上山健彦
- Organizer
  第60回日本組織細胞化学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-17H04042
[Presentation] 活性酸素種（ROS）過剰発現モデルマウスにおける聴覚機能解析と聴覚保護因子の検索2019
- Author(s)
  森岡　繁文、坂口　博史、山口　太郎、二之湯　弦、毛利　宏明、中村　高志、久　育男、荻田　喜代一、齋藤　尚亮、上山　健彦
- Organizer
  第60回日本組織細胞化学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-17H04042
[Presentation] The molecular mechanism of hearing loss caused by a novel DIA1 mutant (R1204X)2017
- Author(s)
  Yuzuru Ninoyu, Shin-ichiro Kitajiri, Takushi Miyoshi, Dean Thumkeo, Hirofumi Sakaguchi, Naoki Watanabe, Shin-ichi Usami, Naoaki Saito, Takehiko Ueyama
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎新聞文化ホール（長崎県・長崎市）
- Year and Date
  2017-03-15
- Data Source
  KAKENHI-PROJECT-26460340
[Presentation] Tricellulin Knockout Mice, a Model of DNFB49, Show Severe Hearing Loss With Cochlear Hair Cell Apoptosis2015
- Author(s)
  Toru Kamitani, Hirofumi Sakaguchi, et al.
- Organizer
  38th Association for Research in Otolaryngology Annual Midwinter Meeting
- Place of Presentation
  Baltimore, USA
- Year and Date
  2015-02-23
- Data Source
  KAKENHI-PROJECT-26462563
[Presentation] 内耳タイト結合の構成分子トリセルリンの機能2015
- Author(s)
  坂口　博史
- Organizer
  第24回耳科学会総会
- Place of Presentation
  新潟
- Year and Date
  2015-10-16
- Invited
- Data Source
  KAKENHI-PROJECT-26462563
[Presentation] The M orphological C hange of Reticular Lamina by T hree M yosin II I nhibitors2014
- Author(s)
  Tomoki Fujita; Hirofumi Sakaguchi; Sigenobu Yonemura; Yasuo Hisa
- Organizer
  The 37th MidWinter Meeting of the Association for Research in Otolaryngology
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-23592491
[Presentation] The morphological change of Reticular Lamina by three myosin II inhibitors2014
- Author(s)
  Fujita T, Sakaguchi H, Yonemura S, Hisa Y
- Organizer
  36th Association for Research in Otolaryngology (ARO) Midwinter Meeting
- Place of Presentation
  サンディエゴ
- Data Source
  KAKENHI-PROJECT-23592491
[Presentation] The involvement of ROCK pathway in the apical cell contraction in murine organ of Corti2013
- Author(s)
  Tomoki Fujita, Hirofumi Sakaguchi, Sigenobu Yonemura, Yasuo Hisa
- Organizer
  36th Association for Research in Otolaryngology MidWinter Meeting
- Place of Presentation
  Baltimore, USA
- Data Source
  KAKENHI-PROJECT-23592491
[Presentation] The morphological change of Reticular Lamina by ROCK inhibitor"2013
- Author(s)
  Fujita T, Sakaguchi H, Yonemura Y, Hisa Y
- Organizer
  36th Association for Research in Otolaryngology (ARO) Midwinter Meeting
- Place of Presentation
  ボルチモア
- Data Source
  KAKENHI-PROJECT-23592491
[Presentation] Molecular Mechanism of the Dynamic Morphological Regulation in Hair Cells2013
- Author(s)
  Sakaguchi H
- Organizer
  The 20th IFOS Congress
- Place of Presentation
  ソウル(シンポジウム)
- Data Source
  KAKENHI-PROJECT-23592491
[Presentation] Dynamic Regulation of the Apical Hair Cell Structures.2012
- Author(s)
  Sakaguchi H.
- Organizer
  14th Japan-Korea Joint Meeting of Otorhinolaryngology
- Place of Presentation
  Kyoto, Japan
- Invited
- Data Source
  KAKENHI-PROJECT-23592491
[Presentation] 内耳発生・再生に関する基礎研究.内耳感覚上皮細胞の形態形成?ミオシンによる動的制御に関して?2012
- Author(s)
  坂口博史
- Organizer
  第22回日本耳科学会.
- Place of Presentation
  名古屋(シンポジウム)
- Data Source
  KAKENHI-PROJECT-23592491
[Presentation] II型ミオシンによる有毛細胞形態の制御機構2012
- Author(s)
  坂口博史,藤田朋己,足立直子,神谷透,中村高志,瀧正勝,兵庫美砂子,鈴木敏弘,米村重信,久育男.
- Organizer
  第113回日本耳鼻咽喉科学会
- Place of Presentation
  新潟
- Data Source
  KAKENHI-PROJECT-23592491
[Presentation] Dynamic Structural Regulation in Hair Cells.2012
- Author(s)
  Sakaguchi H.
- Organizer
  Collegium Oto-Rhino-Laryngologicum Amicitiae Sacrum
- Place of Presentation
  Rome, Italy
- Data Source
  KAKENHI-PROJECT-23592491
[Presentation] From Bench to Clinic : Next Generation in Otology. Dynamic Regulation of the Apical Hair Cell Structures2012
- Author(s)
  Sakaguchi H
- Organizer
  The 14th Japan-Korea Joint Meeting of ORL-HS
- Place of Presentation
  京都(シンポジウム)
- Data Source
  KAKENHI-PROJECT-23592491
[Presentation] 発生期コルチ器におけろ頂側結合の経時的変化2010
- Author(s)
  藤田朋己, 瀧正勝, 坂口博史, ら
- Organizer
  日本耳科学会学術講演会
- Place of Presentation
  松山
- Year and Date
  2010-10-08
- Data Source
  KAKENHI-PROJECT-21791634
[Presentation] Morphological Development of the Reticular Lamina in the Perinatal and Postnatal Mouse.2010
- Author(s)
  Fujita T, Sakaguchi H, Suzuki T, Hisa Y, Yonemura S.
- Organizer
  33^<rd> MidWinter Research Meeting of Association for Research in Otolaryngoloty
- Place of Presentation
  Anaheim, CA, USA
- Year and Date
  2010-02-08
- Data Source
  KAKENHI-PROJECT-21791634
[Presentation] 発生期コルチ器における頂側結合の経時的変化2010
- Author(s)
  藤田朋己、瀧正勝、坂口博史、鈴木敏弘、米村重信、久育男
- Organizer
  日本耳科学会学術講演会
- Place of Presentation
  松山
- Year and Date
  2010-10-08
- Data Source
  KAKENHI-PROJECT-21791634
[Presentation] Morphological Development of the Reticular Lamina in the Perinatal and Postnatal Mouse2010
- Author(s)
  Sakaguchi H, et al.
- Organizer
  33^<rd> MidWinter Research Meeting of Association for Research in Otolaryngoloty
- Place of Presentation
  Anaheim, CA, USA
- Year and Date
  2010-02-08
- Data Source
  KAKENHI-PROJECT-21791634

1. UEYAMA Takehiko (80346254)

# of Collaborated Projects: 7 results

# of Collaborated Products: 10 results
2. 足立直子 (70604510)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 中村高志 (80724179)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. SAITO Naoaki (60178499)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 宮下武憲 (60363214)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. 瀧正勝 (30453111)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. HISHIKAWA Yoshitaka

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
8. USAMI Shin-ichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. NISHIO Shinya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 斎藤尚亮

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
11. チョウジョウフナランツオツク

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Sakaguchi Hirofumi 坂口 博史

SAKAGUCHI Hirofumi 坂口 博史

Research Projects

Research Products

Co-Researchers

活性酸素産生酵素NOX3の発現制御機序解明による後天性及び片側性難聴の治療法開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of acquired SNHL mechanism caused from Nox3-derived ROS and beyond

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Challenge for establishing the criteria of laterality-based diseases in hearing and vision

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation for gene transfer therapy in inner earsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanism clarification of new symptoms in DFNA1 causing from constitutively active DAI1 mutants

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Roles of Rho-family small GTPases in establishment and maintenance for hearing and balancing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of apical junctions in barrier function and structural maintenance of the cochlear sensory epitheliaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Morphological regulation of the developmental inner ear hair cells by non-muscle myosin IIPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Roles of small GTPases and ROS in functions anddiseases of inner ear

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Research in the metabolic dynamics of the molecular component of the tip link, essential structure for hearing receptionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Dispensable role of Rac1 and Rac3 after cochlear hair cell specification2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Nox3-derived superoxide in cochleae induces sensorineural hearing loss.2021

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Nox3-Derived Superoxide in Cochleae Induces Sensorineural Hearing Loss2021

Author(s)

Journal Title

DOI

NAID

Sakaguchi Hirofumi 坂口博史

SAKAGUCHI Hirofumi 坂口博史