Sasanuma Hiroyuki 笹沼博之

… Alternative Names

SASANUMA Hiroyuki 笹沼博之

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Researcher Number	00531691
Other IDs	https://orcid.org/0000-0001-8179-5818
Affiliation (Current)	2024: 公益財団法人東京都医学総合研究所, 基礎医科学研究分野, プロジェクトリーダー
Affiliation (based on the past Project Information) *help	2024: 公益財団法人東京都医学総合研究所, 基礎医科学研究分野, 副参事研究員 2021 – 2022: 公益財団法人東京都医学総合研究所, 基礎医科学研究分野, 副参事研究員 2016 – 2021: 京都大学, 医学研究科, 准教授 2014 – 2015: 京都大学, 大学院医学研究科, 准教授 2012 – 2015: 京都大学, 医学(系)研究科(研究院), 准教授 … More 2012: 京都大学, 大学院・医学研究科, 准教授 2011: 京都大学, 医学(系)研究科(研究院), 助教 2011: 京都大学, 医学研究科, 助教 2010: 大阪大学, 蛋白質研究所員, 特任研究員 2009 – 2010: Osaka University, 蛋白質研究所, 特任研究員 Less
Review Section/Research Field	Principal Investigator Risk sciences of radiation and chemicals / Basic Section 63020:Radiation influence-related / Complex systems / Genetics/Genome dynamics Except Principal Investigator Risk sciences of radiation and chemicals / Basic Section 37010:Bio-related chemistry / Basic Section 45010:Genetics-related / Basic Section 50010:Tumor biology-related / Molecular biology / General medical chemistry / Risk sciences of radiation/Chemicals
Keywords	Principal Investigator 相同組換え / DNA二重鎖切断修復 / ゲノム編集 / トポイソメラーゼ2型 / BRCA1 / トポイソメラーゼ2 / DNA二重鎖切断 / DNA損傷 / ユビキチン / 付加体 … More / 放射線 / トポイソメラーゼ / UBC13 / DNA修復 / がん / トポイソメラーゼ２型 / 乳がん / エストロゲン / オーキシンデグロン / エトポシド / トポイソメラーゼII型 / トポイソメラーゼ２ / ステロイドホルモン / DNA損傷修復 / ゲノム / 遺伝学 / プロテオーム / プロテオミクス / 組換え / 出芽酵母 / 減数分裂 / Dmc1 / Rad51 / 分子遺伝 … More Except Principal Investigator 変異原 / 発がん物質 / 遺伝毒物学 / QSAR / 化審法 / トキシコロジー / ケミカルバイオロジー / グアニン四重鎖 / Ｄループ / ハイブリッド二重鎖 / 相同並行三重鎖 / 相同組換え修復 / Rad51 / RecA / 相同対合反応 / ハイブリッド二重鎖DNA / ヘテロ二重鎖DNA / 組換え中間体 / 相同DNA組換え / 発がん / 乳腺 / 動物モデル / イソフラボン / E2 / Myc / 発酵大麦エキス / 微小浸潤 / 異形成 / 乳癌 / 初期乳がん / 乳がん予防 / エストロゲン / マウスモデル / 乳がん / 抗がん治療薬 / ケモインフォマティクス / TK6細胞 / 人体有害物質 / プロテオーム解析 / ニワトリBリンパ細胞 / DT40 / 標的組換え / DNA組換え / CRISPR/Cas9 / ゲノム編集 / プロテオノミクス / SILAC / 質量分析 / DNA修復 / ユビキトーム / ユビキチン / プロテオミクス / DT40細胞 / データマイニング / 情報学 / はいスループットスクリーニング / 小核試験 / レギュラトリーサイエンス / ハイスループットスクリーニング / 小核実験 / 有害化学物質 / 発がん化学物質 / エームテスト Less

グアニン四重鎖を書換えるG4-editorの開発と当該構造のノックアウト
- Principal Investigator
  
  寺正行
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 37010:Bio-related chemistry
- Research Institution
  Tokyo University of Agriculture and Technology
相同的組換えでの相同並行三重鎖DNAの働き
- Principal Investigator
  
  柴田武彦
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 45010:Genetics-related
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
Establishment of novel mouse early breast cancer induction model for studies of breast tumorigenesis and prevention
- Principal Investigator
  
  Itou Junji
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  National Cardiovascular Center Research Institute
  Foundation for Biomedical Research and Innovation at Kobe
Elucidation of the ubiquitin pathway that removes adducts attached to DNA double-strand breaksPrincipal Investigator
- Principal Investigator
  
  SASANUMA Hiroyuki
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 63020:Radiation influence-related
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
  Kyoto University
Investigation of Molecular Mechanisms Underlying Oncogenesis in HBOC SyndromePrincipal Investigator
- Principal Investigator
  
  笹沼博之
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Kyoto University
ヒトゲノム編集細胞を使った、化学物質の薬理作用・有害性を解析するシステムの構築
- Principal Investigator
  
  Takeda Shunichi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Risk sciences of radiation and chemicals
- Research Institution
  Kyoto University
Establishment of Novel Bioassays for in vivo Genotoxicity Prediction and Mechanism Characterization
- Principal Investigator
  
  Takeda Shunichi
- Project Period (FY)
  2016 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Risk sciences of radiation and chemicals
- Research Institution
  Kyoto University
Elucidation of pathological mechanism caused by defects in the repair of TOPII-induced DNA double-strand breaksPrincipal Investigator
- Principal Investigator
  
  SASANUMA Hiroyuki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Risk sciences of radiation and chemicals
- Research Institution
  Kyoto University
Analysis of a novel regulatory mechanism of DNA damage repair using the combination of proteomics and genetics approarchPrincipal Investigator
- Principal Investigator
  
  Sasanuma Hiroyuki
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Risk sciences of radiation and chemicals
- Research Institution
  Kyoto University
Development of a method for increasing gene-targeting efficiency in human cells
- Principal Investigator
  
  TAKEDA Shunichi
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Molecular biology
- Research Institution
  Kyoto University
Establishment of high-throughput screening of toxic chemical compounds.
- Principal Investigator
  
  Takeda Shunichi
- Project Period (FY)
  2011 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  Kyoto University
Comprehensive Analysis of Ubiquitome during DNA damage response
- Principal Investigator
  
  TAKEDA Shunichi
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General medical chemistry
- Research Institution
  Kyoto University
Functional analysis of Shu complex, a new mediator of Rad51 protein in recombinationPrincipal Investigator
- Principal Investigator
  
  SASANUMA Hiroyuki
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Genetics/Genome dynamics
- Research Institution
  Osaka University

[Book] 月刊血液内科　血液内科領域における抗腫瘍薬の作用機序・副作用に基づく使い分けシスプラチン耐性の分子機構2012
- Author(s)
  笹沼　博之
- Total Pages
  6
- Publisher
  科学評論社
- Data Source
  KAKENHI-PROJECT-23221005
[Journal Article] XRCC1 counteracts poly(ADP ribose)polymerase (PARP) poisons, olaparib and talazoparib, and a clinical alkylating agent, temozolomide, by promoting the removal of trapped PARP1 from broken DNA.2022
- Author(s)
  Hirota Kouji、Ooka Masato、Shimizu Naoto、Yamada Kousei、Tsuda Masataka、Ibrahim Mahmoud Abdelghany、Yamada Shintaro、Sasanuma Hiroyuki、Masutani Mitsuko、Takeda Shunichi
- Journal Title
  
  Genes to Cells
  
  Volume: in press Issue: 5 Pages: 331-344
- DOI
  10.1111/gtc.12929
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H04267, KAKENHI-PROJECT-20H04337, KAKENHI-PROJECT-21K19235, KAKENHI-PROJECT-19KK0210, KAKENHI-PROJECT-16H06279
[Journal Article] FANCD2-Associated Nuclease 1 Partially Compensates for the Lack of Exonuclease 1 in Mismatch Repair2021
- Author(s)
  Kratz Katja、Artola-Born Mariela、Kobayashi-Era Saho、Koh Gene、Oliveira Goncalo、Kobayashi Shunsuke、Oliveira Andreia、Zou Xueqing、Richter Julia、Tsuda Masataka、Sasanuma Hiroyuki、Takeda Shunichi、Loizou Joanna I.、Sartori Alessandro A.、Nik-Zainal Serena、Jiricny Josef
- Journal Title
  
  Molecular and Cellular Biology
  
  Volume: 41 Issue: 9
- DOI
  10.1128/mcb.00303-21
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H04267, KAKENHI-PROJECT-16H06279
[Journal Article] Epigenetic suppression of SLFN11 in germinal center B-cells during B-cell development2021
- Author(s)
  Moribe F, Nishikori M, Takashima T, Taniyama D, Onishi N, Arima H, Sasanuma H, Akagawa R, Elloumi F, Takeda S, Pommier Y, Morii E, Takaori-Kondo A, Murai J.
- Journal Title
  
  PLoS One.
  
  Volume: 16 Issue: 1 Pages: 0237554-0237554
- DOI
  10.1371/journal.pone.0237554
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07696, KAKENHI-PROJECT-16H06306, KAKENHI-PROJECT-19H03452, KAKENHI-PROJECT-19H03505, KAKENHI-PROJECT-18K08324, KAKENHI-PROJECT-19K22561, KAKENHI-PROJECT-19H04267, KAKENHI-PROJECT-16H06279
[Journal Article] XRCC1 prevents toxic PARP1 trapping during DNA base excision repair2021
- Author(s)
  Demin Annie A.、Hirota Kouji、Tsuda Masataka、Adamowicz Marek、Hailstone Richard、Brazina Jan、Gittens William、Kalasova Ilona、Shao Zhengping、Zha Shan、Sasanuma Hiroyuki、Hanzlikova Hana、Takeda Shunichi、Caldecott Keith W.
- Journal Title
  
  Molecular Cell
  
  Volume: 81 Issue: 14 Pages: 3018-3030
- DOI
  10.1016/j.molcel.2021.05.009
- NAID
  120007052730
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H04267, KAKENHI-PROJECT-20H04337, KAKENHI-PROJECT-21K19235, KAKENHI-PROJECT-19KK0210, KAKENHI-PROJECT-16H06279
[Journal Article] Protein phosphatase 1 acts as a RIF1 effector to suppress DSB resection prior to Shieldin action2021
- Author(s)
  Isobe Shin-Ya、Hiraga Shin-ichiro、Nagao Koji、Sasanuma Hiroyuki、Donaldson Anne D.、Obuse Chikashi
- Journal Title
  
  Cell Reports
  
  Volume: 36 Issue: 2 Pages: 109383-109383
- DOI
  10.1016/j.celrep.2021.109383
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06426, KAKENHI-PLANNED-18H05532, KAKENHI-PROJECT-19H04267, KAKENHI-PROJECT-16H06279, KAKENHI-PROJECT-19H03156
[Journal Article] Fanconi anemia proteins participate in a break-induced-replication-like pathway to counter replication stress2021
- Author(s)
  Xu Xinlin、Xu Yixi、Guo Ruiyuan、Xu Ran、Fu Congcong、Xing Mengtan、Sasanuma Hiroyuki、Li Qing、Takata Minoru、Takeda Shunichi、Guo Rong、Xu Dongyi
- Journal Title
  
  Nature Structural & Molecular Biology
  
  Volume: 28 Issue: 6 Pages: 487-500
- DOI
  10.1038/s41594-021-00602-9
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H04267, KAKENHI-PROJECT-20H03450, KAKENHI-PROJECT-20K21394, KAKENHI-PROJECT-16H06279
[Journal Article] PRDX1 is essential for the viability and maintenance of reactive oxygen species in chicken DT402021
- Author(s)
  Moriwaki Takahito、Yoshimura Akari、Tamari Yuki、Sasanuma Hiroyuki、Takeda Shunichi、Seki Masayuki、Tano Keizo
- Journal Title
  
  Genes and Environment
  
  Volume: 43 Issue: 1 Pages: 1-8
- DOI
  10.1186/s41021-021-00211-4
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H04267, KAKENHI-PROJECT-18K11640, KAKENHI-PROJECT-19K07647, KAKENHI-PROJECT-20K17055, KAKENHI-PROJECT-16H06279
[Journal Article] XRCC1 Prevents Toxic PARP1 Trapping During DNA Base Excision Repair.2021
- Author(s)
  Demin AA, Hirota K, Tsuda M, Adamowicz M, Hailstone R, Brazina J, Gittens W, Kalasova I, Shao Z, Zha S, Sasanuma H, Hanzlikova H, Takeda S, Caldecott KW
- Journal Title
  
  Mol Cell
  
  Volume: in press
- NAID
  120007052730
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06306
[Journal Article] Enhancing the sensitivity of the thymidine kinase assay by using DNA repair-deficient human TK6 cells.2020
- Author(s)
  Ibrahim MA, Yasui M, Saha LK, Sasanuma H, Honma M, Takeda S
- Journal Title
  
  Environ Mol Mutagen.
  
  Volume: in press Issue: 6 Pages: 602-610
- DOI
  10.1002/em.22371
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06306, KAKENHI-PROJECT-19H04267
[Journal Article] Genetic evidence for the involvement of mismatch repair proteins, PMS2 and MLH3, in a late step of homologous recombination.2020
- Author(s)
  Rahman MM, Mohiuddin M, Shamima Keka I, Yamada K, Tsuda M, Sasanuma H, Andreani J, Guerois R, Borde V, Charbonnier JB, Takeda S.
- Journal Title
  
  J Biol Chem.
  
  Volume: 295 Issue: 51 Pages: 17460-17475
- DOI
  10.1074/jbc.ra120.013521
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06306, KAKENHI-PROJECT-19H04267, KAKENHI-PROJECT-19K22561
[Journal Article] Tyrosyl-DNA phosphodiesterases are involved in mutagenic events at a ribonucleotide embedded into DNA in human cells2020
- Author(s)
  Takeishi Ayuna、Kogashi Hiroyuki、Odagiri Mizuki、Sasanuma Hiroyuki、Takeda Shunichi、Yasui Manabu、Honma Masamitsu、Suzuki Tetsuya、Kamiya Hiroyuki、Sugasawa Kaoru、Ura Kiyoe、Sassa Akira
- Journal Title
  
  PLOS ONE
  
  Volume: 15 Issue: 12 Pages: 0244790-0244790
- DOI
  10.1371/journal.pone.0244790
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K12339, KAKENHI-PROJECT-16H06306, KAKENHI-PROJECT-19H04267, KAKENHI-PROJECT-19K22561
[Journal Article] TDP2 suppresses genomic instability induced by androgens in the epithelial cells of prostate glands.2020
- Author(s)
  Mahmud RA, Ishii K, Lozano BC, Sainz DI, Toi M, Akamatsu S, Fukumoto M, Watanabe M, Takeda S, Ledesma FC, Sasanuma H
- Journal Title
  
  Genes Cells
  
  Volume: in press
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06306
[Journal Article] UBC13-mediated ubiquitin signaling promotes removal of blocking adducts from DNA double-strand breaks.2020
- Author(s)
  Akagawa R, Trinh TH, Saha LK, Tsuda M, Hirota K, Yamada S, Shibata A, Kanemaki MT, Nakada S, Takeda S, Sasanuma H
- Journal Title
  
  iScience
  
  Volume: 23 Pages: 101027-101027
- NAID
  120006956714
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H06306
[Journal Article] Topoisomerase I-driven repair of UV-induced damage in NER-deficient cells2020
- Author(s)
  Saha Liton Kumar、Wakasugi Mitsuo、Akter Salma、Prasad Rajendra、Wilson Samuel H.、Shimizu Naoto、Sasanuma Hiroyuki、Huang Shar-yin Naomi、Agama Keli、Pommier Yves、Matsunaga Tsukasa、Hirota Kouji、Iwai Shigenori、Nakazawa Yuka、Ogi Tomoo、Takeda Shunichi
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 117 Issue: 25 Pages: 14412-14420
- DOI
  10.1073/pnas.1920165117
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K12319, KAKENHI-PROJECT-19KK0210, KAKENHI-PROJECT-16H06306, KAKENHI-PROJECT-19H04265, KAKENHI-PROJECT-19H04267, KAKENHI-PROJECT-20H04337, KAKENHI-PROJECT-18K19585, KAKENHI-PROJECT-19K22561, KAKENHI-PROJECT-18H03372, KAKENHI-PROJECT-20H00629
[Journal Article] Restoration of ligatable "clean" double-strand break ends is the rate-limiting step in the rejoining of ionizing-radiation-induced DNA breakage.2020
- Author(s)
  Sasanuma H, Yamada S, Tsuda M, Takeda S.
- Journal Title
  
  DNA Repair (Amst)
  
  Volume: 93 Pages: 102913-102913
- DOI
  10.1016/j.dnarep.2020.102913
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06306, KAKENHI-PROJECT-19H04267, KAKENHI-PROJECT-19K20449
[Journal Article] Participation of TDP1 in the repair of formaldehyde-induced DNA-protein cross-links in chicken DT40 cells2020
- Author(s)
  Toshiaki Nakano, Mahmoud I. Shoulkamy, Masataka Tsuda, Hiroyuki Sasanuma, Kouji Hirota, Minoru Takata, Shin-ichiro Masunaga, Shunichi Takeda, Hiroshi Ide, Tadayoshi Bessho, Keizo Tano
- Journal Title
  
  PLOS ONE
  
  Volume: 15 Issue: 6 Pages: 0234859-0234859
- DOI
  10.1371/journal.pone.0234859
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K11640, KAKENHI-PROJECT-19K08171, KAKENHI-PROJECT-16H06306, KAKENHI-PROJECT-18H03374, KAKENHI-PROJECT-19H04267, KAKENHI-PROJECT-19K22561
[Journal Article] Estrogen Induces Mammary Ductal Dysplasia via the Upregulation of Myc Expression in a DNA-Repair-Deficient Condition2020
- Author(s)
  Itou Junji、Takahashi Rei、Sasanuma Hiroyuki、Tsuda Masataka、Morimoto Suguru、Matsumoto Yoshiaki、Ishii Tomoko、Sato Fumiaki、Takeda Shunichi、Toi Masakazu
- Journal Title
  
  iScience
  
  Volume: 23 Issue: 2 Pages: 100821-100821
- DOI
  10.1016/j.isci.2020.100821
- NAID
  120006779803
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07665, KAKENHI-PROJECT-19K09063, KAKENHI-PUBLICLY-18H04900, KAKENHI-PROJECT-19H04267, KAKENHI-PROJECT-18K18200
[Journal Article] UBC13-Mediated Ubiquitin Signaling Promotes Removal of Blocking Adducts from DNA Double-Strand Breaks2020
- Author(s)
  Akagawa Remi、Trinh Hai Thanh、Saha Liton Kumar、Tsuda Masataka、Hirota Kouji、Yamada Shintaro、Shibata Atsushi、Kanemaki Masato T.、Nakada Shinichiro、Takeda Shunichi、Sasanuma Hiroyuki
- Journal Title
  
  iScience
  
  Volume: 23 Issue: 4 Pages: 101027-101027
- DOI
  10.1016/j.isci.2020.101027
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H04719, KAKENHI-PUBLICLY-18H04900, KAKENHI-PROJECT-18H02170, KAKENHI-PROJECT-19H04267, KAKENHI-PROJECT-20K21536, KAKENHI-PROJECT-19KK0210, KAKENHI-PROJECT-17H04713, KAKENHI-PUBLICLY-20H04879, KAKENHI-PROJECT-20H04337
[Journal Article] TDP2 suppresses genomic instability induced by androgens in the epithelial cells of prostate glands.2020
- Author(s)
  Mahmud MRA, Ishii K, Lozano CB, Sainz ID, Toi M, Akamatsu S, Fukumoto M, Watanabe M, Takeda S, Ledesma FC, Sasanuma H.
- Journal Title
  
  Genes to Cells
  
  Volume: in press Issue: 7 Pages: 450-465
- DOI
  10.1111/gtc.12770
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H04900, KAKENHI-PROJECT-19H04267, KAKENHI-PROJECT-19K09686, KAKENHI-PROJECT-20K09539, KAKENHI-PROJECT-19K22684, KAKENHI-PROJECT-18K09131
[Journal Article] Processing of a single ribonucleotide embedded into DNA by human nucleotide excision repair and DNA polymerase η2019
- Author(s)
  Sassa Akira、Tada Haruto、Takeishi Ayuna、Harada Kaho、Suzuki Megumi、Tsuda Masataka、Sasanuma Hiroyuki、Takeda Shunichi、Sugasawa Kaoru、Yasui Manabu、Honma Masamitsu、Ura Kiyoe
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 13910-13910
- DOI
  10.1038/s41598-019-50421-8
- NAID
  120006733134
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K12339, KAKENHI-PROJECT-16H06307, KAKENHI-PROJECT-19H04267, KAKENHI-PROJECT-19J10397, KAKENHI-PROJECT-16K16195
[Journal Article] Spatial Chromosome Folding and Active Transcription Drive DNA Fragility and Formation of Oncogenic MLL Translocations2019
- Author(s)
  Gothe HJ, Bouwman BAM, Gusmao EG, Piccinno R, Petrosino G, Sayols S, Drechsel O, Minneker V, Josipovic N, Mizi A, Nielsen CF, Wagner EM, Takeda S, Sasanuma H, et al
- Journal Title
  
  Molecular Cell
  
  Volume: 75 Issue: 2 Pages: 267-283.e12
- DOI
  10.1016/j.molcel.2019.05.015
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H04267
[Journal Article] PDIP38/PolDIP2 controls the DNA damage tolerance pathways by increasing the relative usage of translesion DNA synthesis over template switching.2019
- Author(s)
  Tsuda M, Ogawa S, Ooka M, Kobayashi K, Hirota K, Wakasugi M, Matsunaga T, Sakuma T, Yamamoto T, Chikuma S, Sasanuma H, Debatisse M, Doherty AJ, Fuchs RP, Takeda S
- Journal Title
  
  PLoS One
  
  Volume: 14 Issue: 3 Pages: e0213383-e0213383
- DOI
  10.1371/journal.pone.0213383
- NAID
  120006822506
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05801, KAKENHI-PUBLICLY-18H04900, KAKENHI-PROJECT-16H06306, KAKENHI-PROJECT-16H02952, KAKENHI-PROJECT-16H02953, KAKENHI-PROJECT-16H02957, KAKENHI-PROJECT-19K12319, KAKENHI-PROJECT-19H04265
[Journal Article] BRCA1 Haploinsufficiency Is Masked by RNF168-Mediated Chromatin Ubiquitylation2019
- Author(s)
  Zong D, Adam S, Wang Y, Sasanuma H, Callen E, Murga M, Day A, Kruhlak MJ, Wong N, Munro M, Ray Chaudhuri A, Karim B, Xia B, Takeda S, Johnson N, Durocher D, Nussenzweig A
- Journal Title
  
  Molecular Cell
  
  Volume: 73 Issue: 6 Pages: 1267-1281
- DOI
  10.1016/j.molcel.2018.12.010
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H04900, KAKENHI-PROJECT-16H06306, KAKENHI-PROJECT-16H02953
[Journal Article] Type II DNA Topoisomerases Cause Spontaneous Double-Strand Breaks in Genomic DNA2019
- Author(s)
  Morimoto S, Tsuda M, Bunch H, Sasanuma H, Austin C, Takeda S
- Journal Title
  
  Genes (Basel)
  
  Volume: 10 Issue: 11 Pages: 868-868
- DOI
  10.3390/genes10110868
- NAID
  120006898175
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H04900, KAKENHI-PROJECT-16H06306, KAKENHI-PROJECT-19H04267
[Journal Article] Disruption of Hif-1α enhances cytotoxic effects of metformin in murine squamous cell carcinoma.2018
- Author(s)
  Sanada Y, Sasanuma H, Takeda S, Tano K, Masunaga S.
- Journal Title
  
  Int J Radiat Biol
  
  Volume: 94 Issue: 1 Pages: 88-96
- DOI
  10.1080/09553002.2018.1409443
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04295, KAKENHI-PROJECT-16H06306, KAKENHI-PROJECT-18K11640, KAKENHI-PROJECT-16H02953
[Journal Article] SUMOylation of PCNA by PIAS1 and PIAS4 promotes template switch in the chicken and human B cell lines2018
- Author(s)
  Mohiuddin Mohiuddin、Evans Terry John、Rahman Md Maminur、Keka Islam Shamima、Tsuda Masataka、Sasanuma Hiroyuki、Takeda Shunichi
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 115 Issue: 50 Pages: 12793-12798
- DOI
  10.1073/pnas.1716349115
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K18200, KAKENHI-PUBLICLY-18H04900, KAKENHI-PROJECT-16H06306, KAKENHI-PROJECT-16H02953
[Journal Article] Differential micronucleus frequency in isogenic human cells deficient in DNA repair pathways is a valuable indicator for evaluating genotoxic agents and their genotoxic mechanisms.2018
- Author(s)
  Saha LK, Kim S, Kang H, Akter S, Choi K, Sakuma T, Yamamoto T, Sasanuma H, Hirota K, Nakamura J, Honma M, Takeda S
- Journal Title
  
  Environ Mol Mutagen.
  
  Volume: 59 Issue: 6 Pages: 529-538
- DOI
  10.1002/em.22201
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06306, KAKENHI-PROJECT-16H02957
[Journal Article] BRCA1 ensures genome integrity by eliminating estrogen-induced pathological topoisomerase II-DNA complexes2018
- Author(s)
  Sasanuma Hiroyuki、Tsuda Masataka、Morimoto Suguru、Saha Liton Kumar、Rahman Md Maminur、Kiyooka Yusuke、Fujiike Haruna、Cherniack Andrew D.、Itou Junji、Callen Moreu Elsa、Toi Masakazu、Nakada Shinichiro、Tanaka Hisashi、Tsutsui Ken、Yamada Shintaro、Nussenzweig Andre、Takeda Shunichi
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 115 Issue: 45
- DOI
  10.1073/pnas.1803177115
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K18200, KAKENHI-PUBLICLY-18H04900, KAKENHI-PROJECT-16H06306, KAKENHI-PROJECT-16H02953, KAKENHI-PROJECT-26241014
[Journal Article] Cytotoxicity of tirapazamine (3-amino-1, 2, 4- benzotriazine-1, 4-dioxide)-induced DNA damage in chicken DT40 cells.2017
- Author(s)
  Moriwaki T, Okamoto S, Sasanuma H, Nagasawa H, Takeda S, Masunaga S, Tano K
- Journal Title
  
  Chem Res Toxicol.
  
  Volume: 30 Issue: 2 Pages: 699-704
- DOI
  10.1021/acs.chemrestox.6b00417
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H06306, KAKENHI-PROJECT-15K00537
[Journal Article] Complementation of aprataxin deficiency by base excision repair enzymes in mitochondrial extracts2017
- Author(s)
  Caglayan M, Prasad R, Krasich R, Longley MJ, Kadoda K, Tsuda M, Sasanuma H, Takeda S, Tano K, Copeland WC and Wilson SH
- Journal Title
  
  Nucleic Acids Res.
  
  Volume: 45 Issue: 17 Pages: 10079-10088
- DOI
  10.1093/nar/gkx654
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K00537, KAKENHI-PROJECT-16H06306, KAKENHI-PROJECT-16H02953
[Journal Article] TDP1 is critical for the repair of DNA breaks induced by sapacitabine, a nucleoside also targeting ATM- and BRCA-deficient tumors.2017
- Author(s)
  Abo MA, Sasanuma H, Liu X, Rajapakse VN, Huang SN, Kiselev E, Takeda S, Plunkett W, Pommier Y
- Journal Title
  
  Mol Cancer Ther.
  
  Volume: 16 Issue: 11 Pages: 2543-2551
- DOI
  10.1158/1535-7163.mct-17-0110
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06306, KAKENHI-PROJECT-16H02953
[Journal Article] Selective cytotoxicity of the anti-diabetic drug, metformin, in glucose-deprived chicken DT40 cells2017
- Author(s)
  Kadoda K, Moriwaki T, Tsuda M, Sasanuma H, Ishiai M, Takata M, Ide H, Masunaga S, Takeda S and Tano K
- Journal Title
  
  PLOS ONE
  
  Volume: 12 Issue: 9 Pages: e0185141-e0185141
- DOI
  10.1371/journal.pone.0185141
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K00537, KAKENHI-PROJECT-15H04295, KAKENHI-PUBLICLY-16H01642, KAKENHI-PROJECT-16H06306, KAKENHI-PROJECT-16H02953
[Journal Article] The dominant role of proofreading exonuclease activity of replicative polymerase ε in cellular tolerance to cytarabine (Ara-C).2017
- Author(s)
  Tsuda M, Terada K, Ooka M, Kobayashi K, Sasanuma H, Fujisawa R, Tsurimoto T, Yamamoto J, Iwai S, Kadoda K, Akagawa R, Huang SN, Pommier Y, Sale JE, Takeda S, Hirota K.
- Journal Title
  
  Oncotarget
  
  Volume: in press Issue: 20 Pages: 33457-33474
- DOI
  10.18632/oncotarget.16508
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25440011, KAKENHI-PUBLICLY-16H01314, KAKENHI-PROJECT-16H06306, KAKENHI-PROJECT-16H02957, KAKENHI-PROJECT-16H04743, KAKENHI-PROJECT-16K12595, KAKENHI-PROJECT-16K12598, KAKENHI-PROJECT-16H02953
[Journal Article] Poor recognition of O6-isopropyl dG by MGMT triggers double strand break-mediated cell death and micronucleus induction in FANC-deficient cells.2016
- Author(s)
  Hashimoto K, Sharma V, Sasanuma H, Tian X, Takata M, Takeda S, Swenberg JA, Nakamura J
- Journal Title
  
  Oncotarget
  
  Volume: 7 Issue: 37 Pages: 59795-59808
- DOI
  10.18632/oncotarget.10928
- NAID
  120005980805
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06306, KAKENHI-PROJECT-15H01738, KAKENHI-PROJECT-16H02953
[Journal Article] The role of the Mre11-Rad50-Nbs1 complex in double-strand break repair-facts and myths.2016
- Author(s)
  Takeda S, Hoa NN, Sasanuma H
- Journal Title
  
  J Radiat Res.
  
  Volume: 57 Suppl 1 Issue: S1 Pages: i25-i32
- DOI
  10.1093/jrr/rrw034
- NAID
  120006027206
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H06306
[Journal Article] The role Mre11-Rad50-Nbs1 complex in double-strand-break repair - Myth and Facts2016
- Author(s)
  Shunichi Takeda, Nguyen Ngoc Hoa, and Hiroyuki Sasanuma,H.
- Journal Title
  
  Journal of Radiation Research
  
  Volume: 1 Pages: 1-1
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26740018
[Journal Article] Mre11 Is Essential for the Removal of Lethal Topoisomerase 2 Covalent Cleavage Complexes.2016
- Author(s)
  Hoa NN, Shimizu T, Zhou ZW, Wang ZQ, Deshpande RA, Paull TT, Akter S, Tsuda M, Furuta R, Tsusui K, Takeda S, Sasanuma H
- Journal Title
  
  Mol Cell
  
  Volume: 64 Issue: 3 Pages: 580-592
- DOI
  10.1016/j.molcel.2016.10.011
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06306, KAKENHI-PROJECT-16H02953
[Journal Article] The Double-Strand Break Landscape of Meiotic Chromosomes Is Shaped by the Paf1 Transcription Elongation Complex in Saccharomyces cerevisiae2016
- Author(s)
  Gothwal, S.K., Patel, N.J., Colletti, M.M., Sasanuma, H., Shinohara, M., Hochwagen, A., and Shinohara, A
- Journal Title
  
  Genetics
  
  Volume: 202 Pages: 497-512
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26740018
[Journal Article] Deazaflavin Inhibitors of Tyrosyl-DNA Phosphodiesterase 2 (TDP2) Specific for the Human Enzyme and Active against Cellular TDP2.2016
- Author(s)
  Marchand C, Abdelmalak M, Kankanala J, Huang SY, Kiselev E, Fesen K, Kurahashi K, Sasanuma H, Takeda S, Aihara H, Wang Z, Pommier Y
- Journal Title
  
  ACS Chem Biol.
  
  Volume: 11 Issue: 7 Pages: 1925-1933
- DOI
  10.1021/acschembio.5b01047
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06306, KAKENHI-PROJECT-16H02953
[Journal Article] The role of HERC2 and RNF8 ubiquitin E3 ligases in the promotion of translesion DNA synthesis in the chicken DT40 cell line.2016
- Author(s)
  Mohiuddin, Kobayashi S, Keka IS, Guilbaud G, Sale J, Narita T, Abdel-Aziz HI, Wang X, Ogawa S, Sasanuma H, Chiu R, Oestergaard VH, Lisby M, Takeda S.
- Journal Title
  
  DNA Repair (Amst)
  
  Volume: 40 Pages: 64-76
- DOI
  10.1016/j.dnarep.2016.02.002
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23221005, KAKENHI-PROJECT-16H06306
[Journal Article] BRCA1 and CtIP are both required to recruit dna2 at double-strand breaks in homologous recombination.2015
- Author(s)
  Nguyen NH, Kobayashi J, Omura M, Hirakawa M, Yang SH, Komatsu K, Paull TT, Takeda S, Sasanuma H
- Journal Title
  
  PLoS One
  
  Volume: in press
- NAID
  120005615636
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26740018
[Journal Article] BRCA1 and CtIP are both required to recruit dna2 at double-strand breaks in homologous recombination.2015
- Author(s)
  Nguyen NH, Kobayashi J, Omura M, Hirakawa M, Yang SH, Komatsu K, Paull TT, Takeda S, Sasanuma H
- Journal Title
  
  PLoS One
  
  Volume: in press
- NAID
  120005615636
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23221005
[Journal Article] BRCA1 and CtIP Are Both Required to Recruit Dna2 at Double-Strand Breaks in Homologous Recombination2015
- Author(s)
  Hoa NN, Kobayashi J, Omura M, Hirakawa M, Yang SH, Komatsu K, Paull TT, Takeda S, Sasanuma H
- Journal Title
  
  Plos one
  
  Volume: 10 (4)
- NAID
  120005615636
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26740018
[Journal Article] BRCA1 and CtIP are both required to recruit dna2 at double-strand breaks in homologous recombination.2015
- Author(s)
  Hoa NN, Kobayashi J, Omura M, Hirakawa M, Yang SH, Komatsu K, Paull TT, Takeda S, Sasanuma H.
- Journal Title
  
  PLoS One
  
  Volume: 10 Issue: 4 Pages: e0124495-e0124495
- DOI
  10.1371/journal.pone.0124495
- NAID
  120005615636
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23221005, KAKENHI-PROJECT-26241013, KAKENHI-PROJECT-15H02819, KAKENHI-PROJECT-26550025
[Journal Article] Relative contribution of four nucleases, CtIP, Dna2, Exo1 and Mre11, to the initial step of DNA double‐strand break repair by homologous recombination in both the chicken DT40 and human TK6 cell lines2015
- Author(s)
  Hoa NN, Akagawa R, Yamasaki T, Hirota K, Sasa K, Natsume T, Kobayashi J, Sakuma T, Yamamoto T, Komatsu K, Kanemaki MT, Pommier Y, Takeda S, Sasanuma H
- Journal Title
  
  Genes to Cells
  
  Volume: 20 Issue: 12 Pages: 1059-1076
- DOI
  10.1111/gtc.12310
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18482, KAKENHI-PUBLICLY-26116518, KAKENHI-PROJECT-23221005, KAKENHI-PROJECT-26550025, KAKENHI-PROJECT-25281021
[Journal Article] Smarcal1 promotes double-strand-break repair by nonhomologous end-joining2015
- Author(s)
  Keka IS, Mohiuddin, Maede Y, Rahman MM, Sakuma T, Honma M, Yamamoto T, Takeda S, Sasanuma H
- Journal Title
  
  Nucleic Acid Research
  
  Volume: 13 Issue: 13 Pages: 6259-6372
- DOI
  10.1093/nar/gkv621
- NAID
  120005617590
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25340044, KAKENHI-PROJECT-23221005
[Journal Article] Abacavir, an anti-HIV-1 drug, targets TDP1-deficient adult T cell leukemia2015
- Author(s)
  Tada, K., Kobayashi, M*., et al, Sasanuma, H, Takeda, S, Takaori-K, A
- Journal Title
  
  Science advances
  
  Volume: 1
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26740018
[Journal Article] Relative contribution of four nucleases, CtIP, Dna2, Exo1 and Mre11, to the initial step of DNA double-strand break repair by homologous recombination in both the chicken DT40 and human TK6 cell lines2015
- Author(s)
  Hoa NN, Akagawa R, Yamasaki T, et al., Sasanuma H
- Journal Title
  
  Genes to Cells
  
  Volume: 20 (12) Pages: 1059-1076
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26740018
[Journal Article] Smarcal1 promotes double-strand-break repair by nonhomologous end-joining2015
- Author(s)
  Keka IS, Mohiuddin, Maede Y, Rahman MM, Sakuma T, Honma M, Yamamoto T, Takeda S, Sasanuma H
- Journal Title
  
  Nucleic Acids Res
  
  Volume: 43 (13) Pages: 6359-6372
- NAID
  120005617590
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26740018
[Journal Article] Abacavir, an anti–HIV-1 drug, targets TDP1-deficient adult T cell leukemia.2015
- Author(s)
  Tada K, Kobayashi M, Takiuchi Y, Iwai F, Sakamoto T, Nagata K, Shinohara M, Io K, Shirakawa K, Hishizawa M, Shindo K, Kadowaki N, Hirota K, Yamamoto J, Iwai S, Sasanuma H, Takeda S, Takaori-Kondo A.
- Journal Title
  
  Science Advances
  
  Volume: 1 Issue: 3 Pages: 1-9
- DOI
  10.1126/sciadv.1400203
- NAID
  120005601014
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-24115004, KAKENHI-PUBLICLY-26116518, KAKENHI-PROJECT-23221005, KAKENHI-PROJECT-25281021
[Journal Article] SUMO-targeted ubiquitin ligase RNF4 plays a critical role in preventing chromosome loss.2014
- Author(s)
  Hirota K, Tsuda M, Murai J, Takagi T, Keka IS, Narita T, Fujita M, Sasanuma H, Kobayashi J, Takeda S
- Journal Title
  
  Genes Cells
  
  Volume: 19 Issue: 10 Pages: 743-754
- DOI
  10.1111/gtc.12173
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23221005, KAKENHI-PROJECT-25281021, KAKENHI-PROJECT-25650006, KAKENHI-PUBLICLY-26116518
[Journal Article] Interference in DNA replieation can cause mitotic chromosomal breakage unassociated with double-strand breaks2013
- Author(s)
  Fujita Mari, Sasanuma H, Kimiyo N. Yamamoto Harada H, Kurosawa A, Adachi N, Omura M, Hiraoka M, Takeda S, Hirota K.
- Journal Title
  
  PLos One
  
  Volume: 8 Issue: 4 Pages: 60043-60043
- DOI
  10.1371/journal.pone.0060043
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-13J06811, KAKENHI-PROJECT-23221005, KAKENHI-PROJECT-23659152, KAKENHI-PUBLICLY-24114509, KAKENHI-PROJECT-24659035, KAKENHI-PROJECT-25281021
[Journal Article] タイトル『減数分裂期特異的DNA二重鎖切断機構』2009
- Author(s)
  笹沼博之、太田邦史
- Journal Title
  
  染色体サイクル(蛋白質核酸酵素・特集号)
  
  Pages: 459-465
- Data Source
  KAKENHI-PROJECT-21770005
[Journal Article] Rec8 Guides Canonical Spoll Distribution along Yeast Meiotic Chromosomes.2009
- Author(s)
  Kugou, K., Fukuda, T., Yamada, S., Ito, M., Sasanuma, H., Mori, S., Katou, Y., Itoh, T., Matsumoto, K., Shibata, T., et al.
- Journal Title
  
  Mol Biol Cell 345
  
  Pages: 1939-4586
- Data Source
  KAKENHI-PROJECT-21770005
[Journal Article] Cdc7-dependent phosphorylation of Mer2 facilitates initiation of yeast meiotic recombination.2008
- Author(s)
  Sasanuma, H., Hirota, K., Fukuda, T., Kakusho, N., Kugou, K., Kawasaki, Y., Shibata, T., Masai, H., Ohta, K.
- Journal Title
  
  Genes Dev 22
  
  Pages: 398-410
- Data Source
  KAKENHI-PROJECT-21770005
[Journal Article] Targeted induction of meiotic double-strand breaks reveals chromosomal domain-dependent regulation of Spo11 and interactions among potential sites of meiotic recombination.2008
- Author(s)
  Fukuda, T., Kugou, K., Sasanuma, H., Shibata, T., Ohta, K.
- Journal Title
  
  Nucleic Acids Res 36
  
  Pages: 984-997
- Data Source
  KAKENHI-PROJECT-21770005
[Journal Article] Mrell mediates gene regulation in yeast spore development.2007
- Author(s)
  Kugou, K., Sasanuma, H., Matsumoto, K., Shirahige, K., Ohta, K.
- Journal Title
  
  Genes Genet Syst 82
  
  Pages: 21-33
- Data Source
  KAKENHI-PROJECT-21770005
[Presentation] がん抑制遺伝子BRCA2の遺伝子ネットワーク解析2021
- Author(s)
  笹沼博之
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19H04267
[Presentation] 難治性DNA損傷がもたらす疾患発症の分子機構2020
- Author(s)
  笹沼博之
- Organizer
  難病のプロテオ医学２０２０『Cell Growth, Replication Stress and Genomic Instability in Cancer』
- Invited
- Data Source
  KAKENHI-PROJECT-19H04267
[Presentation] 難治性DNA損傷とその修復の分子機構2020
- Author(s)
  笹沼博之
- Organizer
  分子生物学会
- Invited
- Data Source
  KAKENHI-PROJECT-19H04267
[Presentation] A novel role of BRCA1 in the repair of estrogen-induced pathological topoisomerase II-DNA complex2020
- Author(s)
  Hiroyuki Sasanuma
- Organizer
  第78回日本癌学会学術総会シンポジウム
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H04267
[Presentation] BRCA1-Mre11 ensures genome integrity by eliminating estrogen-induced pathological Topoisomerase II-DNA complexes2019
- Author(s)
  Hiroyuki Sasanuma
- Organizer
  5th HiHA International Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02953
[Presentation] Alternate processing pathways of a single ribonucleotide incorporated into DNA and its consequences in human cells.2019
- Author(s)
  Akira SASSA, Haruto TADA, Ayuna TAKEISHI, Kaho HARADA, Kazuma NAKATANI, Masataka TSUDA, Hiroyuki SASANUMA, Shunichi TAKEDA, Kaoru SUGASAWA, Manabu YASUI, Masamitsu HONMA, Kiyoe URA
- Organizer
  The Joint Meeting of The 6th Asian Congress on Environmental Mutagens and The 48th Japanese Environmental Mutagen Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06306
[Presentation] BRCA1 and BRCA2 protect transcriptional response to estrogens from abortive catalysis by Topoisomerase II2019
- Author(s)
  Rahman MM, Sasanuma H, Tsuda M, Morimoto S, Yamada S, Nussenzweig A, Tanaka H, Takeda S
- Organizer
  FASEB Science Research Conference “The Genetic Recombination and Genome Rearrangements Conference”
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06306
[Presentation] BRCA1-Mre11 ensures genome integrity by eliminating estrogen-induced pathological Topoisomerase II-DNA complexes2019
- Author(s)
  Hiroyuki Sasanuma
- Organizer
  5th HiHA International Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H04900
[Presentation] DNA二重鎖切断末端の付加体の除去はいかにして行われるか？2019
- Author(s)
  笹沼博之
- Organizer
  核酸代謝鶴岡カンファレンス
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H04267
[Presentation] Mechanistic insight of unique mutations caused by a ribonucleotide embedded into DNA.2019
- Author(s)
  Ayuna TAKEISHI, Manabu YASUI, Hiroyuki SASANUMA, Shunichi TAKEDA, Kaoru SUGASAWA, Masamitsu HONMA, Kiyoe URA, Akira SASSA
- Organizer
  The Joint Meeting of The 6th Asian Congress on Environmental Mutagens and The 48th Japanese Environmental Mutagen Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06306
[Presentation] K63-ubiquitination signaling promotes end-processing of double-strand breaks for subsequent nonhomologous joining2018
- Author(s)
  Takeda S, Sasanuma H, Akagawa R
- Organizer
  第77回日本癌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-16H06306
[Presentation] BRCA1 ensures genome integrity by eliminating estrogen-induced pathological Topoisomerase II-DNA complexes2018
- Author(s)
  Hiroyuki Sasanuma
- Organizer
  IPR international seminar
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02953
[Presentation] BRCA1は、静止期細胞においてTop2依存的なDNA二重鎖切断修復に関与する2018
- Author(s)
  笹沼博之
- Organizer
  第90回遺伝学会
- Invited
- Data Source
  KAKENHI-PROJECT-16H02953
[Presentation] BRCA1 ensures genome integrity by eliminating estrogen-induced pathological Topoisomerase II-DNA complexes2018
- Author(s)
  Hiroyuki Sasanuma
- Organizer
  第41回分子生物学会
- Data Source
  KAKENHI-PUBLICLY-18H04900
[Presentation] BRCA1は、静止期細胞においてTop2依存的なDNA二重鎖切断修復に関与する2018
- Author(s)
  笹沼博之
- Organizer
  第90回遺伝学会
- Data Source
  KAKENHI-PUBLICLY-18H04900
[Presentation] ２本のDNAの絡みを解消する酵素、トポイソメラーゼ２は、温度変化により触媒反応に失敗する頻度が増えDNA２重鎖切断を作る2018
- Author(s)
  武田俊一、笹沼博之、Akter S
- Organizer
  日本ハイパーサーミア学会
- Invited
- Data Source
  KAKENHI-PROJECT-16H06306
[Presentation] BRCA1 ensures genome integrity by eliminating estrogen-induced pathological Topoisomerase II-DNA complexes2018
- Author(s)
  Hiroyuki Sasanuma
- Organizer
  第41回分子生物学会
- Invited
- Data Source
  KAKENHI-PROJECT-16H02953
[Presentation] SUMO化蛋白質を認識するRING型ユビキチンリガーゼRNF4による、スピンドルアセンブリチェックポイント(SAC)活性維持と染色体ロスの防止2017
- Author(s)
  廣田耕志、高木季代、津田雅貴、村井純子、Keka Islam, 成田岳雄、藤田真梨、笹沼博之、小林純也、武田俊一
- Organizer
  SUMO研究会
- Place of Presentation
  関西学院大学（大阪府・大阪市）
- Year and Date
  2017-01-22
- Invited
- Data Source
  KAKENHI-PROJECT-16H06306
[Presentation] Mre11 Is Essential for the Removal of Lethal Topoisomerase 2 Covalent Cleavage Complexes2017
- Author(s)
  Takeda S, Sasanuma H
- Organizer
  ATW2017 Ataxia-Telangiectasia Workshop
- Place of Presentation
  ミラノ（イタリア）
- Year and Date
  2017-03-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06306
[Presentation] BRCA1 and Mre11 maintain genome integrity by eliminating abortive Topoisomerase complexes2017
- Author(s)
  Takeda S, Sasanuma H
- Organizer
  8th international symposium on DNA Damage Response & Human Disease (isDDRHD-2017)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06306
[Presentation] The essential roleof Mre11-Rad50-Nbs1 complex in the removal of abortive top2-DNA complex2017
- Author(s)
  Hiroyuki Sasanuma
- Organizer
  33rd International Symposium of Radiation Biology Center, Kyoto University
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02953
[Presentation] Mre11蛋白質は、DNAに共有結合したTopIIを除去するのに必須である。2017
- Author(s)
  笹沼博之
- Organizer
  分子生物学会
- Invited
- Data Source
  KAKENHI-PROJECT-16H02953
[Presentation] Mre11 Is Essential for the Removal of Lethal Topoisomerase 2 Covalent Cleavage Complexes2017
- Author(s)
  Takeda S, Sasanuma H
- Organizer
  Keystone Symposia, DNA Replication and Recombination
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06306
[Presentation] Mre11 Is Essential for the Removal of Lethal Topoisomerase 2 Covalent Cleavage Complexes2016
- Author(s)
  Hiroyuki Sasanuma
- Organizer
  3R symposium
- Place of Presentation
  島根県松江
- Year and Date
  2016-11-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02953
[Presentation] SUMO化蛋白質を認識するRING型ユビキチンリガーゼRNF4による、スピンドルアセンブリチェックポイント(SAC)活性維持と染色体ロスの防止2016
- Author(s)
  廣田　耕志、高木　季代、津田　雅貴、村井　純子、Keka Islam、成田　岳雄、藤田　真梨、笹沼　博之、小林　純也、武田　俊一
- Organizer
  SUMO研究会
- Place of Presentation
  大阪
- Year and Date
  2016-01-22
- Data Source
  KAKENHI-PROJECT-23221005
[Presentation] ヒト細胞を用いたDNA損傷修復研究の純遺伝学解析2015
- Author(s)
  笹沼博之、武田俊一
- Organizer
  Genome damage network workshop
- Place of Presentation
  伊香保、群馬
- Year and Date
  2015-06-27
- Invited
- Data Source
  KAKENHI-PROJECT-26740018
[Presentation] BRCA1 and CtIP are Both Required to Recruit Dna2 at Double-Strand Breaks in Homologous Recombination,2015
- Author(s)
  Hoa NN, Kobayashi J, Omura M, Tsuda M, Hirota K, Komatsu K, Takeda S, Sasanuma H,
- Organizer
  2nd IFOM-Kyoto univ. joint symposium
- Place of Presentation
  京都大学
- Year and Date
  2015-10-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26740018
[Presentation] Differential roles of Mre11 nuclease in DNA damage responses in the budding yeast and mammalian cells2015
- Author(s)
  Hoa NN, Kobayashi J, Omura M, Hirakawa M, Yang SH, Paull TT, Komatsu K, Takeda S, Sasanuma H
- Organizer
  16th Ataxia-Telangiectasia Workshop (ATW2015)
- Place of Presentation
  Beijing, China
- Year and Date
  2015-10-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23221005
[Presentation] Collaboration of BRCA1, CtIP, and Dna2 is required to initiate double-strand break repair by homologous recombination2015
- Author(s)
  Hoa NN, Kobayashi J, Omura M, Tsuda M, Hirota K, Hirakawa M, Yang SH, Paull TT, Komatsu K, Takeda S, Sasanuma H
- Organizer
  FASEB Science Research Conferences, Genetic Recombination and Genome Rearrangements
- Place of Presentation
  Steamboat Springs, Colorado, USA
- Year and Date
  2015-07-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23221005
[Presentation] Collaboration between the CtIP and Dna2 nucleases is required to create 3' single-stranded ends at double-strand breaks in homologous recombination.2014
- Author(s)
  Nguyen NH, Kobayashi J, Omura M, Tsuda M, Hirota K, Komatsu K, Takeda S, Sasanuma H
- Organizer
  Fusion Conferences, Functional Polymeric Materials
- Place of Presentation
  Cancun, Mexico
- Data Source
  KAKENHI-PROJECT-23221005
[Presentation] DNA二重鎖切断末端の削り込みにおけるCtIPとDna2による協調的な働き2013
- Author(s)
  笹沼博之, Nguyen Ngoc Hoa, 小林純也, 小村将人, 津田雅貴, 廣田耕志, 小松賢志, 武田俊一
- Organizer
  第22回DNA複製・組換え・修復ワークショップ
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-23221005
[Presentation] DNA二重鎖切断末端修飾におけるCtIPとDna2蛋白質の機能解析2013
- Author(s)
  笹沼博之, Nguyen Ngoc Hoa, 小林純也, 小村将人, 津田雅貴, 廣田耕志, 小松賢志, 武田俊一
- Organizer
  第36回日本分子生物学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23221005
[Presentation] Collaboration between the CtIP and Dna2 nucleases is required to create 3' single-stranded ends at double-strand breaks in homologous recombination.2013
- Author(s)
  Sasanuma H, Nguyen NH, Kobayashi J, Omura M, Tsuda M, Hirota K, Komatsu K, Takeda S
- Organizer
  RBC Symposium
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23221005
[Presentation] Collaboration between the CtIP and Dna2 nucleases is required to create 3’ single-stranded ends at double-strand breaks in homologous recombination.2013
- Author(s)
  Takeda S, Nguyen NH, Sasanuma H
- Organizer
  2013 FASEB Science Research Conferences, Genetic Recombination & Genome Rearrangements
- Place of Presentation
  Steamboat Springs, Colorado, USA
- Data Source
  KAKENHI-PROJECT-23221005
[Presentation] Roles of histone modification enzymes, Set1 and Dot1, and the PAF transcription elongation complex during meiosis2011
- Author(s)
  Miki Shinohara, Hiroyuki Sasanuma, Mohamad Bani, Akira Shinohara
- Place of Presentation
  Fukuoka, Japan
- Data Source
  KAKENHI-PROJECT-21770005
[Presentation] PCSS complex facilitates the loading of Rad51 recombinase onto meiotic chromosomes2010
- Author(s)
  Hiroyuki Sasanuma, Maki Tawaramoto, Miki Shinohara, Akira Shinohara
- Organizer
  3R symposium
- Place of Presentation
  Toyama
- Data Source
  KAKENHI-PROJECT-21770005
[Presentation] PCSS complex facilitates the loading of Rad51 recombinase onto meiotic chromosomes2010
- Author(s)
  Hiroyuki Sasanuma, Maki Tawaramoto, Miki Shinohara, Akira Shinohara
- Organizer
  Epigenome Network, Development and Reprogramming of Germ Cells
- Place of Presentation
  Fukuoka, Japan
- Data Source
  KAKENHI-PROJECT-21770005
[Presentation] Shu complex promotes the assembly of Rad51 on meiotic chromosomes2010
- Author(s)
  笹沼博之
- Organizer
  3R symposium
- Place of Presentation
  富山県国際会議場
- Data Source
  KAKENHI-PROJECT-21770005
[Presentation] Rad51蛋白質の活性を制御する二つの因子PCSS複合体とSrs2蛋白質の解析2010
- Author(s)
  笹沼博之、俵元麻貴、篠原美紀、篠原彰
- Organizer
  核ダイナミクス研究会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-21770005
[Presentation] 減数分裂期組換えに関与するShu蛋白質の機能解析2009
- Author(s)
  笹沼博之、俵元麻貴、篠原美紀、篠原彰
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-21770005
[Presentation] 減数分裂期DNA鎖組換え反応に関与するShu蛋白質の機能解析2009
- Author(s)
  笹沼博之
- Organizer
  染色サイクル若手研究会
- Place of Presentation
  御殿場、静岡、日本
- Data Source
  KAKENHI-PROJECT-21770005
[Presentation] PCSS複合体は、Rad51蛋白質の染色体上への結合を促進する2009
- Author(s)
  笹沼博之
- Organizer
  3Rワークショップ2009
- Place of Presentation
  滋賀、日本
- Data Source
  KAKENHI-PROJECT-21770005
[Presentation] Shu complex promotes the assembly of Rad51 on meiotic chromosomes2009
- Author(s)
  Hiroyuki Sasanuma, Maki Tawaramoto, Miki Shinohara, Akira Shinohara
- Organizer
  IUBMB
- Place of Presentation
  Shunghai, China
- Data Source
  KAKENHI-PROJECT-21770005
[Presentation] 減数分裂期組換えに関与するShu蛋白質の機能解析2009
- Author(s)
  笹沼博之
- Organizer
  核ダイナミクス研究会
- Place of Presentation
  修善寺、静岡、日本
- Data Source
  KAKENHI-PROJECT-21770005
[Presentation] Functional analysis of Shul/Shu2/Csm2/Psy3 complex in meiosis2009
- Author(s)
  笹沼博之
- Organizer
  IUBMB & 12th FAOBMB International Congress of Biochemistry and Molecular Biology
- Place of Presentation
  上海、中国
- Data Source
  KAKENHI-PROJECT-21770005
[Presentation] 減数分裂期におけるShu複合体の機能解析2008
- Author(s)
  笹沼博之、三田理恵、俵元麻貴、篠原美紀、篠原彰
- Organizer
  酵母遺伝学フォーラム
- Place of Presentation
  北海道
- Data Source
  KAKENHI-PROJECT-21770005
[Presentation] Shu complex promotes the assembly of Rad51 on meiotic chromosomes2008
- Author(s)
  Hiroyuki Sasanuma, Miki Shinohara, Akira Shinohara
- Place of Presentation
  Shizuoka, Japan
- Data Source
  KAKENHI-PROJECT-21770005
[Presentation] SUMO化タンパク質を認識するRING型ユビキチンリガーゼRNF4による、スピンドルアセンブリチェックポイント(SAC)の活性維持と染色体ロスの防止
- Author(s)
  廣田耕志、高木季代、津田雅貴、村井純子、Keka Islam、成田岳雄、藤田真梨、笹沼博之、小林純也、武田俊一
- Organizer
  分子生物学会
- Place of Presentation
  横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-23221005
[Presentation] Collaboration of BRCA1, CtIP, and Dna2 is required to initiate double-strand break repair by homologous recombination.
- Author(s)
  Sasanuma H, Takeda S
- Organizer
  The 9th 3R Symposium Together with National Institute of Genetics “2014 International Symposium” “3R and beyond”
- Place of Presentation
  御殿場
- Year and Date
  2014-11-17 – 2014-11-21
- Data Source
  KAKENHI-PROJECT-23221005
[Presentation] 複製ポリメラーゼδPOLD3/p66サブユニットはポリメラーゼζ経路と独立に損傷乗り越えに寄与する
- Author(s)
  廣田耕志、村井純子、Guillaume Guilbaud、津田雅貴、成田岳雄、西原佳那、笹沼博之、釣本俊樹、Julian Sale、武田俊一
- Organizer
  染色体ワークショップ
- Place of Presentation
  広島
- Year and Date
  2014-12-15 – 2014-12-17
- Data Source
  KAKENHI-PROJECT-23221005
[Presentation] Collaboration of BRCA1, CtIP, and Dna2 is required to initiate double-strand break repair by homologous recombination.
- Author(s)
  武田俊一、笹沼博之
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Invited
- Data Source
  KAKENHI-PROJECT-23221005
[Presentation] Collaboration of BRCA1, CtIP, and Dna2 is required to initiate double-strand break repair by homologous recombination.
- Author(s)
  Sasanuma H, Takeda S
- Organizer
  Keystone Symposia, DNA Replication and Recombination
- Place of Presentation
  Whistler, British Columbia, Canada
- Year and Date
  2015-03-01 – 2015-03-06
- Data Source
  KAKENHI-PROJECT-23221005

1. Takeda Shunichi (60188191)

# of Collaborated Projects: 5 results

# of Collaborated Products: 40 results
2. HIROTA Kouji (00342840)

# of Collaborated Projects: 3 results

# of Collaborated Products: 13 results
3. SHIMIZU Hiroyasu (60340551)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 津田雅貴 (00734104)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
5. YAMADA Ryo (50301106)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. OKADA Tetsuya (70378529)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. TAKAHASHI Ryosuke (90216771)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. Itou Junji (10638844)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. 安井学 (50435707)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
10. Brown John (90583188)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 柴田武彦 (70087550)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 正井久雄 (40229349)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 寺正行 (10643512)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. ONISHI Nobuyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. HONMA Masamitsu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 増永慎一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
17. 真田悠生

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 田野恵三

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
19. 佐々彰

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
20. 竹馬俊介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 若杉光生

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 松永司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 夏目豊彰

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 長尾恒治

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 釣本敏樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. 鐘巻将人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. 高折晃史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. 新堂啓祐

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Sasanuma Hiroyuki 笹沼 博之

SASANUMA Hiroyuki 笹沼 博之

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Elucidation of the ubiquitin pathway that removes adducts attached to DNA double-strand breaksPrincipal Investigator

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Investigation of Molecular Mechanisms Underlying Oncogenesis in HBOC SyndromePrincipal Investigator

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Elucidation of pathological mechanism caused by defects in the repair of TOPII-induced DNA double-strand breaksPrincipal Investigator

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Analysis of a novel regulatory mechanism of DNA damage repair using the combination of proteomics and genetics approarchPrincipal Investigator

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Functional analysis of Shu complex, a new mediator of Rad51 protein in recombinationPrincipal Investigator

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[Book] 月刊血液内科 血液内科領域における抗腫瘍薬の作用機序・副作用に基づく使い分け シスプラチン耐性の分子機構2012

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Sasanuma Hiroyuki 笹沼博之

SASANUMA Hiroyuki 笹沼博之

[Book] 月刊血液内科　血液内科領域における抗腫瘍薬の作用機序・副作用に基づく使い分けシスプラチン耐性の分子機構2012