DOI Ryoichiro 土肥良一郎

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DOI RYOICHIRO 土肥良一郎

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Researcher Number	00817786
Other IDs
Affiliation (Current)	2025: 長崎大学, 医歯薬学総合研究科(医学系), 講師
Affiliation (based on the past Project Information) *help	2018 – 2024: 長崎大学, 病院(医学系), 助教 2021 – 2023: 長崎大学, 医歯薬学総合研究科(医学系), 客員研究員
Review Section/Research Field	Principal Investigator Basic Section 55040:Respiratory surgery-related / Basic Section 53030:Respiratory medicine-related Except Principal Investigator Basic Section 55040:Respiratory surgery-related / Basic Section 55010:General surgery and pediatric surgery-related / Basic Section 55020:Digestive surgery-related / Medium-sized Section 90:Biomedical engineering and related fields
Keywords	Principal Investigator 肺再生 / 細胞治療 / 脱細胞化 / 肺胞オルガノイド / in vitro モデル / マイクロ流体デバイス / 肺線維症 / オルガノイド / 再生 / 肺 … More / 肺線維芽細胞 / 2型肺胞上皮細胞 / 線維芽細胞 / ダイレクトリプログラミング / 脂肪由来幹細胞 / 肺再生医療 / 血管内皮細胞 / 共培養 / 脱分化脂肪細胞 / Muse細胞 / 肺胞上皮細胞 / 細胞外マトリックス / 脂肪組織由来間葉系幹細胞 / 空気血管関門 … More Except Principal Investigator 肺再生 / 臓器移植 / 臓器保存 / ナノバブル / 幹細胞 / 生理的刺激 / 移植 / 肺胞バリア機能 / 接着因子 / バリア機能 / バイオリアクター / 再生医学 / 再細胞化 / 脱細胞化 / 医工学 / 再生医療 / Ⅱ型肺胞オルガノイド / 組織再生 / デザイナー細胞 / 細胞治療 / 肺オルガノイド / 臍帯由来間葉系幹細胞 / 腸オルガノイド / オルガノイド / マイクロ流体デバイス / 血管化 / オルガノイド移植 / 気管移植 / ゼラチンマイクロスフィア / ゼラチンマイクロスフェア / 成長因子 / 人工気管 / 細胞凝集 / バイオ3Dプリンター / 軟骨分化 / 創感染 / 創傷治癒 / 臓器保存液 / 肺移植 / 血管内皮 / 肺胞上皮 / ニッチ / 血管 / 臓器工学 / 組織骨格 / 血管ニッチ / 生理劇刺激 / 脂肪幹細胞 / 拒絶反応 / 脂肪肝細胞 / 呼吸器外科学 / 気管支瘻 / 肺瘻 / 悪性胸膜中皮腫 / 胸膜欠損 / 胸膜癒着 / 中皮細胞 / 中皮 / 癒着防止 / 胸膜 / 羊膜 Less

腸オルガノイド細胞による立体構造体を用いた炎症性腸疾患に対する新たな治療法の確立
- Principal Investigator
  
  西牟田雅人
- Project Period (FY)
  2024 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Nagasaki University
Establishment of an in vitro human pulmonary fibrosis model using a novel culture system of alveolar organoidsPrincipal Investigator
- Principal Investigator
  
  土肥良一郎
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Nagasaki University
オルガノイド由来II型肺細胞とデザイナー臍帯MSCの共移植による革新的細胞治療の創出
- Principal Investigator
  
  岩竹真弓
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  Nagoya University
肺オルガノイド細胞療法による肺再生の基盤技術の開発
- Principal Investigator
  
  吉元崇文
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  Nagasaki University
ウルトラファインバブル(ナノバブル)水を使用した創傷治癒促進戦略
- Principal Investigator
  
  大石海道
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Nagasaki University
Development of an Artificial Cylindrical Organ Fabrication Method Using Gelatin Microspheres with Growth Factor Administration
- Principal Investigator
  
  Uchida Fumitake
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Nagasaki University
ケミカルダイレクトリプログラミングによる肺胞上皮細胞誘導法の開発Principal Investigator
- Principal Investigator
  
  土肥良一郎
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  Nagasaki University
Establishing the Efficacy and System Development for Clinical Application of a Novel Organ Preservation Solution Using Nanobubbles
- Principal Investigator
  
  Hara Ryosuke
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  Nagasaki University
The optimization of physiological stimulation for ex vivo lung bioengineering and the establishment of an international foundational study network
- Principal Investigator
  
  TSUCHIYA TOMOSHI
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 90:Biomedical engineering and related fields
- Research Institution
  Nagasaki University
Development of a Novel Respiratory Surgical Coating Material Using Freeze- and Vaccum-Dried Human Amniotic Membranes
- Principal Investigator
  
  Nagayasu Takeshi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  Nagasaki University
Development of rejection control method by mesenchymal stem cells using original rat lung transplantation model
- Principal Investigator
  
  MIYAZAKI TAKURO
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  Nagasaki University
Establishment of hybrid vascular niche in regenerated organs using organ scaffolds and transplantation research
- Principal Investigator
  
  TSUCHIYA TOMOSHI
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  University of Toyama
  Nagasaki University
Basic research on stem cell therapy using adipose tissue-derived mesenchymal stem cells for refractory lung diseasesPrincipal Investigator
- Principal Investigator
  
  DOI RYOICHIRO
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  Nagasaki University

All 2024 2023 2022 2021 2020 2019

All Journal Article Presentation

[Journal Article] Designer umbilical cord-stem cells induce alveolar wall regeneration in pulmonary disease models2024
- Author(s)
  Iwatake Mayumi、Nagamura-Inoue Tokiko、Doi Ryoichiro、Tanoue Yukinori、Ishii Mitsutoshi、Yukawa Hiroshi、Matsumoto Keitaro、Tomoshige Koichi、Nagayasu Takeshi、Tsuchiya Tomoshi
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 15 Pages: 1-13
- DOI
  10.3389/fimmu.2024.1384718
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08977, KAKENHI-PROJECT-23K08299, KAKENHI-PROJECT-21K08907, KAKENHI-PROJECT-20KK0255
[Journal Article] Increased In Vitro Intercellular Barrier Function of Lung Epithelial Cells Using Adipose-Derived Mesenchymal Stem/Stromal Cells2021
- Author(s)
  Ishii Mitsutoshi、Tsuchiya Tomoshi、Doi Ryoichiro、Morofuji Yoichi、Fujimoto Takashi、Muto Hideki、Suematsu Takashi、Mori Ryoichi、Matsumoto Keitaro、Miyazaki Takuro、Tomoshige Koichi、Watanabe Hironosuke、Iwatake Mayumi、Nagayasu Takeshi
- Journal Title
  
  Pharmaceutics
  
  Volume: 13 Issue: 8 Pages: 1264-1264
- DOI
  10.3390/pharmaceutics13081264
- NAID
  120007172252
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10840, KAKENHI-PROJECT-18K16424, KAKENHI-PROJECT-21H04838, KAKENHI-PROJECT-19H03747, KAKENHI-PROJECT-20K09351, KAKENHI-PROJECT-21K08907, KAKENHI-PROJECT-20K20479, KAKENHI-PROJECT-21K16635, KAKENHI-PROJECT-20KK0254, KAKENHI-PROJECT-20KK0255
[Journal Article] Lung Microvascular Niche, Repair, and Engineering.2020
- Author(s)
  Tsuchiya T, Doi R, Obata T, Hatachi G, Nagayasu T.
- Journal Title
  
  Front Bioeng Biotechnol.
  
  Volume: 8 Pages: 105-105
- DOI
  10.3389/fbioe.2020.00105
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03747
[Presentation] 超低流量肺灌流によるマウス脱細胞化手法のシステム開発2024
- Author(s)
  丸山圭三郎、土肥良一郎、吉元崇文、土谷智史、松本桂太郎
- Organizer
  第23回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-23K27613
[Presentation] バイオ3Dプリンターで間葉系幹細胞から分化誘導した軟骨を積層し、気管軟骨を作製する試み2023
- Author(s)
  松本　理宗、内田　史武、松本　桂太郎、町野　隆介、小山　正三朗、森山　正章、原　亮介、大石　海道、西牟田　雅人、土肥　良一郎、朝重　耕一、宮﨑　拓郎、土谷　智史、中山　功一、永安　武
- Organizer
  第22回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-21K08647
[Presentation] 超低流量肺灌流によるマウス脱細胞化手法のシステム開発2023
- Author(s)
  丸山圭三郎、土肥良一郎、吉元崇文、土谷智史、松本桂太郎
- Organizer
  第23回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-22K08978
[Presentation] バイオ3Dプリンターで間葉系幹細胞から分化誘導した軟骨を積層し、気管軟骨を作製する試み2023
- Author(s)
  松本理宗，内田史武，松本　桂太郎，町野　隆介，原　亮介，大石　海道，西牟田　雅人，土肥　良一郎，朝重　耕一，宮崎　拓郎，土谷　智史，中山　功一，永安　武
- Organizer
  第22回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-21K08647
[Presentation] ラット肺移植モデルを用いた脂肪由来間葉系幹細胞の投与タイミングの違いによる免疫抑制効果の検討2022
- Author(s)
  田上幸憲、土谷智史、岩竹真弓、吉元崇文、中司交明、高村祐磨、松本桂太郎、宮﨑拓郎、朝重耕一、土肥良一郎、永安武
- Organizer
  第38回　日本肺および心肺移植研究会
- Data Source
  KAKENHI-PROJECT-19K09309
[Presentation] 間葉系幹細胞から分化させた軟骨を，バイオ3Dプリンターで積層して気管軟骨を作製する試み2022
- Author(s)
  内田史武，松本　桂太郎，町野　隆介，小山　正三朗，森山　正章，原　亮介，大石　海道，松本　理宗，西牟田　雅人，土肥　良一郎，朝重　耕一，宮崎　拓郎，土谷　智史，中山　功一，永安　武
- Organizer
  第21回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-21K08647
[Presentation] ラット肺移植モデルを用いた脂肪由来間葉系幹細胞の投与タイミングの違いによる免疫抑制効果の検討2021
- Author(s)
  田上幸憲、土谷智史、岩竹真弓、吉元崇文、中司交明、高村祐磨、松本桂太郎、宮﨑拓郎、朝重耕一、土肥良一郎、永安武
- Organizer
  第47回　日本臓器保存生物医学会学術集会
- Data Source
  KAKENHI-PROJECT-19K09309
[Presentation] 人工臓器の現状と展開-外科治療のコペルニクス的大転換・再建から再生へ-　肺再生研究の現状と展開　臓器構造を再現する過程で見えてきた課題2021
- Author(s)
  土谷智史、土肥良一郎、溝口聡、石井光寿、小畑智裕、畑地豪、酒井宏水、田中義正、池田裕明、Laura Niklason、永安武
- Organizer
  第121回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-18K16424
[Presentation] 脱細胞化臓器骨格を利用した肺再生研究の10年の歩み2021
- Author(s)
  土谷智史、土肥良一郎、溝口聡、松本桂太郎、宮崎拓郎、朝重耕一、町野隆介、永安武
- Organizer
  第38回日本呼吸器外科学会学術集会
- Data Source
  KAKENHI-PROJECT-18K16424
[Presentation] Transwell共培養システムを用いた脂肪組織由来間葉系幹細胞による肺細胞間バリア機能増強効果の解析2019
- Author(s)
  石井　光寿、土谷　智史、土肥　良一郎、溝口　聡、松本　桂太郎、畑地　豪、渡邉　洋之助、永安　武
- Organizer
  日本肺サーファクタント・界面医学会
- Data Source
  KAKENHI-PROJECT-19H03747

1. Nagayasu Takeshi (80284686)

# of Collaborated Projects: 8 results

# of Collaborated Products: 7 results
2. TSUCHIYA TOMOSHI (30437884)

# of Collaborated Projects: 8 results

# of Collaborated Products: 7 results
3. 松本桂太郎 (80404268)

# of Collaborated Projects: 7 results

# of Collaborated Products: 5 results
4. 高木克典 (90635856)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
5. 渡邉洋之助 (30457551)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. 谷口大輔 (20773758)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
7. 町野隆介 (90728081)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
8. 野中隆 (30606463)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
9. 岩竹真弓 (40624614)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
10. 畑地豪 (80437889)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. 小山正三朗 (20815972)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. 朝重耕一 (70457547)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
13. 富永哲郎 (60457546)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
14. MIYAZAKI TAKURO (00584749)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. Hara Ryosuke (80866286)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. Uchida Fumitake (00866270)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
17. 長井一浩 (30304942)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 上松聖典 (30380843)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 北岡隆 (80234235)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 山本和子 (10398167)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 鳴瀧彩絵 (10508203)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 湯川博 (30634646)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 諸藤陽一 (40437869)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
24. 李桃生 (50379997)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 佐原寿史 (90452333)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 溝口聡 (20816706)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 大石海道 (00899536)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. 馬場雅之 (90771957)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. 吉元崇文 (60899532)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
30. 西牟田雅人 (70855759)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. 清水雄介 (10327570)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. 中山功一 (50420609)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. 桂廣亮 (00894411)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
34. 坂本憲穂 (30448493)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
35. 佐藤香枝 (40373310)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
36. 森本充 (70544344)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
37. 長村登紀子 (70240736)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
38. 藤本隆史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
39. 田上幸憲

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

DOI Ryoichiro 土肥 良一郎

DOI RYOICHIRO 土肥 良一郎

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Establishment of an in vitro human pulmonary fibrosis model using a novel culture system of alveolar organoidsPrincipal Investigator

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ケミカルダイレクトリプログラミングによる肺胞上皮細胞誘導法の開発Principal Investigator

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Basic research on stem cell therapy using adipose tissue-derived mesenchymal stem cells for refractory lung diseasesPrincipal Investigator

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[Journal Article] Designer umbilical cord-stem cells induce alveolar wall regeneration in pulmonary disease models2024

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[Journal Article] Increased In Vitro Intercellular Barrier Function of Lung Epithelial Cells Using Adipose-Derived Mesenchymal Stem/Stromal Cells2021

Author(s)

DOI Ryoichiro 土肥良一郎

DOI RYOICHIRO 土肥良一郎

[Presentation] 人工臓器の現状と展開-外科治療のコペルニクス的大転換・再建から再生へ-　肺再生研究の現状と展開　臓器構造を再現する過程で見えてきた課題2021