Kojima Yasuhiro 小嶋泰弘

Researcher Number	00881731
Other IDs
Affiliation (Current)	2025: 国立研究開発法人国立がん研究センター, 研究所, ユニット長
Affiliation (based on the past Project Information) *help	2023 – 2024: 国立研究開発法人国立がん研究センター, 研究所, ユニット長 2022 – 2023: 名古屋大学, 医学系研究科, 特任講師 2021: 名古屋大学, 医学系研究科, 特任助教 2020: 名古屋大学, 医学系研究科, 研究員
Review Section/Research Field	Principal Investigator Basic Section 62010:Life, health and medical informatics-related / 0901:Oncology and related fields Except Principal Investigator Basic Section 50010:Tumor biology-related / Basic Section 54010:Hematology and medical oncology-related / Medium-sized Section 50:Oncology and related fields
Keywords	Principal Investigator 深層生成モデル / 空間トランスクリプトーム / 細胞内局在 / 細胞間コミュニケーション / がん多様性 / 因子分解 / 一細胞RNA-seq / 深層学習 / 細胞間相互作用 / 一細胞トランスクリプトーム … More Except Principal Investigator … More シミュレーション / クロストーク / 共局在 / scRNA / VISIUM / 空間的シングルセル解析 / クロストーク遺伝子 / MSI-H大腸癌 / 空間的転写産物解析 / シングルセル解析 / 共局在細胞 / がん微小環境 / 抗原提示機構 / MSI-H大腸がん / 前がん病変 / 免疫寛容 / 空間的シングルセルトランスクリプトーム解析 / MPN / single cell RNA / 骨髄増殖性腫瘍 / １細胞解析 / がん / 多様性 / 薬剤耐性 / がん細胞多様性 / メラノーマ / 乳がん / SWI/SNF / ARID2 / エピゲノム Less

Sequence based understanding of subcellular trascrittore dynamicsPrincipal Investigator
- Principal Investigator
  
  小嶋泰弘
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 62010:Life, health and medical informatics-related
- Research Institution
  National Cancer Center Japan
Exploring lineage determining factors for human megakaryocytes or erythroid differentiation in patients with JAK2 V617F by a novel fluctuation-based methodology
- Principal Investigator
  
  永春圭規
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Mie University
大腸がん細胞との共局在により悪性度と免疫寛容を獲得するがん微小環境の解明
- Principal Investigator
  
  三森功士
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Kyushu University
Revealing molecular mechanisms of cancer cell heterogeneity induced by inter-cellular interactionPrincipal Investigator
- Principal Investigator
  
  Kojima Yasuhiro
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0901:Oncology and related fields
- Research Institution
  Nagoya University
Unraveling tumor phenotypic heterogeneity by single-cell epigenetic profiling
- Principal Investigator
  
  Hinohara Kunihiko
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 50:Oncology and related fields
- Research Institution
  Nagoya University

All 2024 2023 2021

All Journal Article Presentation

[Journal Article] Single-cell colocalization analysis using a deep generative model2024
- Author(s)
  Kojima Yasuhiro、Mii Shinji、Hayashi Shuto、Hirose Haruka、Ishikawa Masato、Akiyama Masashi、Enomoto Atsushi、Shimamura Teppei
- Journal Title
  
  Cell Systems
  
  Volume: 15 Issue: 2 Pages: 180-192
- DOI
  10.1016/j.cels.2024.01.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K16991, KAKENHI-PROJECT-22K07000, KAKENHI-PLANNED-23H04938, KAKENHI-PROJECT-22H04925
[Journal Article] Spatial and single-cell colocalisation analysis reveals MDK-mediated immunosuppressive environment with regulatory T cells in colorectal carcinogenesis2024
- Author(s)
  Hashimoto Masahiro、Kojima Yasuhiro et. al.
- Journal Title
  
  eBioMedicine
  
  Volume: 103 Pages: 105102-105102
- DOI
  10.1016/j.ebiom.2024.105102
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K16991, KAKENHI-PROJECT-22K08894, KAKENHI-PROJECT-22K09006, KAKENHI-PROJECT-23K06662, KAKENHI-PROJECT-23K08215, KAKENHI-PROJECT-21K07179, KAKENHI-PLANNED-23H04938, KAKENHI-PROJECT-23K24164, KAKENHI-PROJECT-23K24941
[Journal Article] Spatial and single-cell transcriptomics decipher the cellular environment containing HLA-G+ cancer cells and SPP1+ macrophages in colorectal cancer2023
- Author(s)
  Ozato Y, Mimori K(28番目）,他26名
- Journal Title
  
  Cell Reports
  
  Volume: 42 Issue: 1 Pages: 111929-111929
- DOI
  10.1016/j.celrep.2022.111929
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08908, KAKENHI-PROJECT-22K19464, KAKENHI-PROJECT-22H04925, KAKENHI-PROJECT-20H04281, KAKENHI-PROJECT-19K07659, KAKENHI-PROJECT-20K21832, KAKENHI-PUBLICLY-22H04839, KAKENHI-PROJECT-23K24164, KAKENHI-PROJECT-22K08894, KAKENHI-PROJECT-22K09006, KAKENHI-PROJECT-23K06662, KAKENHI-PROJECT-23K08128, KAKENHI-PROJECT-21K07179
[Presentation] Inferring cell state dynamics dependent on tumor microenvironments2023
- Author(s)
  Yasuhiro Kojima
- Organizer
  2nd JCA-AACR Precision Cancer Medicine International Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K16991
[Presentation] 空間トランスクリプトームの一細胞分解に基づく細胞間共局在関係の推定2021
- Author(s)
  小嶋泰弘
- Organizer
  日本数理生物学会年会
- Data Source
  KAKENHI-PROJECT-20K22839

1. Hinohara Kunihiko (50549467)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 加藤真一郎 (40751417)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 永春圭規 (80883462)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 杉本由香 (00456732)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 三森功士 (50322748)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. 新井田厚司 (00772493)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 鈴木穣 (40323646)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 長山聡 (70362499)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Kojima Yasuhiro 小嶋 泰弘

Research Projects

Research Products

Co-Researchers

Sequence based understanding of subcellular trascrittore dynamicsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Exploring lineage determining factors for human megakaryocytes or erythroid differentiation in patients with JAK2 V617F by a novel fluctuation-based methodology

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

大腸がん細胞との共局在により悪性度と免疫寛容を獲得するがん微小環境の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Revealing molecular mechanisms of cancer cell heterogeneity induced by inter-cellular interactionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Unraveling tumor phenotypic heterogeneity by single-cell epigenetic profiling

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Single-cell colocalization analysis using a deep generative model2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Spatial and single-cell colocalisation analysis reveals MDK-mediated immunosuppressive environment with regulatory T cells in colorectal carcinogenesis2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Spatial and single-cell transcriptomics decipher the cellular environment containing HLA-G+ cancer cells and SPP1+ macrophages in colorectal cancer2023

Author(s)

Journal Title

DOI

Data Source

[Presentation] Inferring cell state dynamics dependent on tumor microenvironments2023

Author(s)

Organizer

Data Source

[Presentation] 空間トランスクリプトームの一細胞分解に基づく細胞間共局在関係の推定2021

Author(s)

Organizer

Data Source

Kojima Yasuhiro 小嶋泰弘