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HORIUCHI Seikoh  堀内 正公

ORCIDConnect your ORCID iD *help
Researcher Number 10117377
Other IDs
External Links
Affiliation (based on the past Project Information) *help 2004: 熊本大, 教授
2003: 熊本大学, 大学院・医学薬学研究部, 教授
1992 – 2002: 熊本大学, 医学部, 教授
1999: 熊本大学, 医学研究科, 教授
1990 – 1991: 熊本大学, 医学部, 講師
1987 – 1988: 熊本大学, 医学部, 講師
1986: 熊本大, 医学部, 講師
Review Section/Research Field
Principal Investigator
Metabolomics / 内分泌・代謝学 / Pathological medical chemistry / General medical chemistry / Biological Sciences / Metabolomics
Except Principal Investigator
Metabolomics / Biological pharmacy / 老化(加齢) / 内分泌・代謝学 / Kidney internal medicine / Pediatrics / Metabolomics
Keywords
Principal Investigator
AGE / マクロファージ / 糖尿病合併症 / 泡沫細胞 / スカベンジャーレセプター / AGE受容体 / 動脈硬化 / スカベンジャー受容体 / Reverse Cholesterol Transport / Diabetic Complications … More / コレステロール逆転送系 / メイラード反応 / diabetic complications / aging / CD36 / RAGE / グリケーション / 老化現象 / メイラード反応後期生成物 / SR-BI / Galectin-3 / Atherosclerosis / Maillard reaction / Oxidative stress / 動脈硬化症 / macrophage / ACAT / scavenger receptor / advanced glycation end products (AGE) / 糖尿病 / 老化 / レセプター介在エンドサイトーシス / アセチルLDL / リポ蛋白 / ノックアウトマウス / 細胞膜レセプター / Receptor / Diabetic complications / Aging process / Nonenzymatic glycosylation / メイラー反応 / 非酵素的糖付加反応 / AGE-Receptor / Maillard Reaction Endproducts / Scavenger Receptor / AGE Receptor / Maillard Reaction endproduct / HDL metabolism / Glycation / HDL代謝 / insulin receptor / P13 kinase / intracellular signal transduction / insulin / advanced glycation end products (AGF) / インスリン受容体(HIR) / スカベンジャー受容体(MSR) / MAP kinase / lyn / インスリン受容体 / 細胞内情報伝達系 / PI3 kinase / インスリン / メイラード後期生成物(AGE) / cDNA cloning / foam cells / cholesterol metabolism / cDNAクローニング / コレステロール代謝 / posttranslational protein modification / crosslinking / fluorescence / main AGE-structure / 抗AGE特異抗体 / 主要蛍光物質 / 主要AGE構造体 / 後期反応生成物(AGE) / 翻訳後蛋白修飾 / AGE(Advanced Glycation End-Products) / メイラード後期生成物 / 糖化反応 / vascular smooth muscle cells / macrophages / AGE receptor / 血管平滑筋細胞 / AGEレセプター / メイラード反応後期生成物(AGE) / アンタゴニスト / SR-A / GAピリジン / リガンド構造 / ガレクチン / コレステロ / カベオリン / ステロイド生産臓器 / コレステロールエステル選択的輸送系 / HDL / 増殖シグナル / リゾリン脂質 / 酸化LDL / マクロファージ増殖 / レセプタークローニング … More
Except Principal Investigator
ACAT / マクロファージ / AGE / 動脈硬化 / CD36 / VEGF / Tetrandrine / differentiation / macrophage / コレステロールエステル / 泡沫細胞 / galectin-3 / カルボキシメチルリジン / Bystander effect / N-Myristoylation / HIV-1 / Angiogenesis / 血管新生 / 酸化LDL / リゾフォスファチジルコリン / AGE受容体 / 糖尿病 / 老化 / メイラード反応 / Nifedipine / Tumor Necrosis Factor-alpha / Choroidal Capillary / N^ε-(carboxymethyl)lysine / Advanced Glycation End Product / THF-α / 糖尿病性網膜症 / 網膜 / Advanced Glycation Endproduct / 腫瘍懐死因子-alpha / Fangchinoline / 血管内皮増殖因子 / 腫瘍壊死因子-alpha / 脈絡膜 / Advanced Glycation End Products / cholesterol ester / foam cells / atherosclerosis / vitamin D / vesicle / cholesteryl ester / dementia / aging / astrocytes / receptor for AGE / pentosidine / N^<epsilon>- (carboxymethyl) lysine / advanced glycation end products (AGE) / ピック病 / アルツハイマー病 / 封入体 / advanced glycation and products / Alzheimer's disease / amyloid β protein / astrocyte / advanced glycation and products(AGE) / 痴呆 / アストロサイト / ガレクチン-3 / ペントシジン / advanced glycation end products(AGE) / HiIV-1 / Oxidized LDL / Adhesion molecule / Phenotypic conversion / Vascular smooth muscle cell / Vasculogenesis / Vascular endothelial cell / Atherosclerosis / 酸化LDL受容体 / ずり応力 / LOX-1 / 接着分子 / 形質転換 / 血管平滑筋細胞 / 血管形成 / 血管内皮細胞 / 粥状動脈硬化 / extracellular matrix / Maillard reaction / kidney / diabetes mellitus / 血管合併症 / 糸球体 / メサンギウム細胞 / 糖化反応 / 糖尿病性腎症 / 糖化反応最終産物 / 細胞外マトリックス / 腎臓 / Small G Protein / 増殖因子 / HDL / VLDL容体 / VLDL受容体 / Rho / SDMF / コレステロール逆転送系 / CETP / M-CSF / macrophage foam cells / reverse cholesterol transport / atheroscierosis / LCAT / A-II / LpA-I / immunoaffinity chromatography / high densitiy lipoprotins / lipoprotins containing apoA-I / apoA-II / apoA-I / アポ蛋白AーI含有リポ蛋白 / アポ蛋白Aー1含有リポ蛋白 / リポ蛋白 / 糖尿病性血管合併症 / RAGE / SR-A / ヒト単球遊走活性 / 臨床マーカー / 蛍光物質 / グリケーション / Advanced glycation end products (AGE) / NO合成酵素 / 変性LDL Less
  • Research Projects

    (29 results)
  • Co-Researchers

    (40 People)
  •  アディポサイトカインに対する化学修飾蛋白の効果とアディポネクチンの抗動脈硬化作用Principal Investigator

    • Principal Investigator
      堀内 正公
    • Project Period (FY)
      2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Kumamoto University
  •  AGE受容体のリガンド構造と受容体アンタゴニストの開発Principal Investigator

    • Principal Investigator
      堀内 正公
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Metabolomics
    • Research Institution
      Kumamoto University
  •  ヒト未梢血単球の遊走現象を担う新規AGE受容体の同定と機能分析

    • Principal Investigator
      堺 政和
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Metabolomics
    • Research Institution
      Kumamoto University
  •  Roles of CD36 and SR-BI as novel AGE-receptorsPrincipal Investigator

    • Principal Investigator
      HORIUCHI Seikoh
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Metabolomics
    • Research Institution
      Kumamoto University
  •  Roles of AGE for mechanism of angiogenesis

    • Principal Investigator
      KOBAYASHI Shinjiro
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Biological pharmacy
    • Research Institution
      Hokuriku University
  •  Regulation of ACAT in diabetes and insuliln resistant

    • Principal Investigator
      MIYAZAKI Akira
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Metabolomics
    • Research Institution
      Kumamoto University
  •  分泌型スカベンジャー受容体、ガレクチン3のエンドサイトーシス機能の解析Principal Investigator

    • Principal Investigator
      堀内 正公
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Metabolomics
    • Research Institution
      Kumamoto University
  •  AGE Structures and their Biomedical SignificancePrincipal Investigator

    • Principal Investigator
      HORIUCHI Seikoh
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (A).
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Kumamoto University
  •  Role of AGE Receptors in Diabetic ComplicationsPrincipal Investigator

    • Principal Investigator
      HORIUCHI Seikoh
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      Metabolomics
    • Research Institution
      Kumamoto University
  •  HDLによる細胞コレステロール搬出系におけるカベオリンの意義Principal Investigator

    • Principal Investigator
      堀内 正公
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Metabolomics
    • Research Institution
      Kumamoto University
  •  Regulation of ACAT, an enzyme involved in cholesterol esterification and foam cell formation in vascular walls

    • Principal Investigator
      MIYAZAKI Akira
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Metabolomics
    • Research Institution
      Kumamoto University
  •  コレステロールエステルのステロイド産生臓器への選択的輸送系の細胞遺伝学的解析Principal Investigator

    • Principal Investigator
      堀内 正公
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      内分泌・代謝学
    • Research Institution
      Kumamoto University
  •  Molecular Mechanism of Atherosclerosis

    • Principal Investigator
      KITA Toru
    • Project Period (FY)
      1997 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      KYOTO UNIVERSITY
  •  Biological clearance system for advanced glycation end products (AGE) -Insulin signal regulates endocytic uptake of AGE-proteinsPrincipal Investigator

    • Principal Investigator
      HORIUCHI Seikoh
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      内分泌・代謝学
    • Research Institution
      Kumamoto University
  •  The switch for initiation of tumorigenesis and infectivity of HIV-1 : Protein N-myristoylation

    • Principal Investigator
      SHOJI Shozo
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Biological pharmacy
    • Research Institution
      Kumamoto University
  •  Significance of advanced glycation end products in brain aging

    • Principal Investigator
      KIMURA Takemi
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      老化(加齢)
    • Research Institution
      Kumamoto University
  •  動脈硬化の成因および病態解明に関する総合的研究

    • Principal Investigator
      MATSUZAWA Yuji
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      内分泌・代謝学
    • Research Institution
      Osaka University
  •  メイラード反応後期生成物の主要構造と、老化や糖尿病における生体内発現様式の解析

    • Principal Investigator
      ARAKI Norie
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      老化(加齢)
    • Research Institution
      Kumamoto University
  •  酸化LDLによるマクロファージ増殖機構の解析-特にリゾリン脂質の細胞内情報伝達における役割についてPrincipal Investigator

    • Principal Investigator
      堀内 正公
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      内分泌・代謝学
    • Research Institution
      Kumamoto University
  •  Molecular Biology of Acyl-coenzyme A : cholesterol AcyltransferasePrincipal Investigator

    • Principal Investigator
      HORIUCHI Seikoh
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Kumamoto University
  •  Detemination of The Main Advanced Glycation End Product of The Maillard Reaction and Its Significance as A Biochemical Marker for Diabetic ComplicationsPrincipal Investigator

    • Principal Investigator
      HORIUCHI Seikoh
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      内分泌・代謝学
    • Research Institution
      Kumamoto University
  •  Role of advanced glycation end-product in the development and progression of diabetic nephropathy.

    • Principal Investigator
      MAKINO Hirofumi
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Kidney internal medicine
    • Research Institution
      Okayama University
  •  Structure and Function of Receptors for Advanced Glycation End Products of the Maillard ReactionPrincipal Investigator

    • Principal Investigator
      HORIUCHI Seikoh
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      General medical chemistry
    • Research Institution
      Kumamoto University
  •  メイラード反応後期生成物に対する細胞膜レセプターの構造と機能Principal Investigator

    • Principal Investigator
      堀内 正公
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      General medical chemistry
    • Research Institution
      Kumamoto University
  •  動脈硬化症の分子生物学的解析と予防・抑制対策に関する総合的研究

    • Principal Investigator
      北 徹
    • Project Period (FY)
      1992 – 1993
    • Research Category
      Grant-in-Aid for Co-operative Research (A)
    • Research Field
      内分泌・代謝学
    • Research Institution
      Kyoto University
  •  Function and structure of high density lipoproteins during childhood

    • Principal Investigator
      OHTA Takao
    • Project Period (FY)
      1990 – 1991
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Kumamoto University
  •  マクロファージによる化学修飾リポ蛋白の認識とコレステロール蓄積機構との相関Principal Investigator

    • Principal Investigator
      堀内 正公
    • Project Period (FY)
      1987
    • Research Category
      Grant-in-Aid for Special Project Research
    • Research Institution
      Kumamoto University
  •  Non-enzymatic glycosylation of proteins in biological sytem and its physiological significance in aging process.Principal Investigator

    • Principal Investigator
      HORIUCHI Seikoh
    • Project Period (FY)
      1987 – 1988
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Kumamoto University
  •  マクロファージによる化学修飾リポ蛋白の認識とコレステロール蓄積機構との相関Principal Investigator

    • Principal Investigator
      堀内 正公
    • Project Period (FY)
      1986
    • Research Category
      Grant-in-Aid for Special Project Research
    • Research Institution
      Kumamoto University
  • 1.  MIYAZAKI Akira (70253721)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 2.  MATSUZAWA Yuji (70116101)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 3.  KITA Toru (60161460)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 4.  YAMADA Nobuhiro (40200729)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 5.  斎藤 康 (50101358)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  ARAKI Norie (80253722)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  HAKAMATA Hideki (70284750)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 8.  OHTA Takao (70185271)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 9.  堺 政和 (40346979)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 10.  高橋 潔 (70045631)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 11.  MAEDA Kenji (90023853)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  MAKINO Hirofumi (50165685)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  SHIKATA Kenichi (00243452)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  ANDO Joji (20159528)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  MARUYAMA Ikuro (20082282)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  ARAKI Eiichi (10253733)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  SHOJI Shozo (60040317)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  TAKAHASHI Ichiro (40091045)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  MISUMI Shogo (40264311)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  FURUISHI Kazuchika (40238663)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  KIMURA Takemi (50284766)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  MIYAKAWA Taihei (90040542)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  NAGAI Ryoji (20315295)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  TAKEYA Motohiro (90155052)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  KOBAYASHI Shinjiro (10186744)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  横山 光宏 (40135794)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 27.  池田 康夫 (00110883)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 28.  池田 剛 (80295138)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 29.  山本 徳男 (30192412)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 30.  高井 義美 (60093514)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 31.  IENAGA Kazuharu
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 32.  YAMAJI Hiroaki
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 33.  CHANG Ta-Yuan
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 34.  KOIKE Hiroyuki
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 35.  CHANG TaーYua
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 36.  PAUL J.Thorn
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 37.  BARD Smedsro
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 38.  JOHN W.Bayne
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 39.  VINCENT M. M
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 40.  HAGINO Nobuyoshi
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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