KOBATA Tetsuji 小端哲二

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OBATA Tetsuji 小端哲二

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Researcher Number	10205445
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2012 – 2014: 獨協医科大学, 医学部, 教授 2002 – 2005: 獨協医科大学, 医学部, 教授 1997 – 1998: 順天堂大学, 医学部, 講師 1990 – 1991: 順天堂大学, 医学部, 講師 1990: 順天堂大学, 医学部・免疫学, 講師 1989: 順天堂大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Immunology / Immunology / 膠原病・アレルギー・感染症内科学 Except Principal Investigator Neurology / Immunology
Keywords	Principal Investigator NF-κB2 / CD19 / TACI / BAFF-R / BLyS / BAFF / アポトーシス / FasL / Fas / 自己免疫 … More / follicular dendritic cell / germinal center / B-cell selection / チロシン・リン酸化 / 共刺激 / CD21 / NF-κB / 補助刺激 / 濾胞樹状細胞 / 胚中心 / B細胞選択 / gene therapy / bone marrow transplantation / self-tolerance / apoptosis / gld mice / autoimmunity / 遺伝子治療 / 骨髄移植 / 免疫寛容 / gldマウス / 制御性T細胞 / HIF-1α / B細胞分化 / 解糖系 / HIF-1a / ILー2R / ILー2 / T細胞活性化 / T細胞分化 / 胸腺 / 10D1 / ヒトT細胞抗原 … More Except Principal Investigator lymphocyte / tolerance / mAb / VLA / LFA / autoimmune disease / animal model / lipo-oligosaccharide / molecular mimicry / Guillain-Barre syndrome / 疾患モデル / リポ多糖 / Campylobacter jejuni / 症例対照試験 / Haemophilus influenzae / フィッシャー症候群 / 自己免疫疾患 / 動物モデル / リポオリゴ糖 / 分子相同性 / ギラン・バレー症候群 / CD4 / トランスフェクタント / TcR / CD2 / lympocyte Less

Regulatory roles of HIF-1a and glycolysis in autoimmunityPrincipal Investigator
- Principal Investigator
  
  KOBATA Tetsuji
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Dokkyo Medical University
Synergistic effects of BAFF/BLyS and CD19 on B-cell responses in germinal centersPrincipal Investigator
- Principal Investigator
  
  KOBATA Tetsuji
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Dokkyo Medical University
Pathogenesis of Guillain-Barre syndrome and Fisher syndromes : evidence of molecular mimicry
- Principal Investigator
  
  YUKI Nobuhiro
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  Dokkyo University School of Medicine
Role of Fas/FasL interaction in self-tolerance : evaluated by bone marrow transplantationPrincipal Investigator
- Principal Investigator
  
  KOBATA Tetsuji
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Juntendo University
ヒトT細胞膜抗原10D1の胸線内T細胞分化・活性化における役割の解析Principal Investigator
- Principal Investigator
  
  小端哲二
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Juntendo University
Immuno-Melecular characterization of lymphocyte functioning antigen (LFA)
- Principal Investigator
  
  OKUMURA Ko
- Project Period (FY)
  1989 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  Juntendo University School of Medicine

All 2014 2013 2005 Other

All Journal Article Presentation Book

[Book] サイトカイン・増殖因子用語ライブラリー(菅村和夫, 宮園浩平, 宮澤恵二, 田中伸幸編)2005
- Author(s)
  小端哲二(分担執筆)
- Publisher
  APRIL, BAFF/Blys
- Data Source
  KAKENHI-PROJECT-16590410
[Book] サイトカニン・増殖因子用語ライブラリー(菅村和夫、宮園浩平、宮澤恵ニ、田中伸幸編)2005
- Author(s)
  小端哲二
- Publisher
  羊土社(分担執筆)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590410
[Journal Article] CD2-mediated regulation of peripheral CD4+CD25+ regulatory T cell apoptosis accompanied with down regulation of Bim2013
- Author(s)
  Kashiwakura Y, Sakurai D, Kanno Y, Hashiguchi M, Kobayashi A, Kurosu A, Tokudome S, Kobata T, Kojima H.
- Journal Title
  
  Immunology
  
  Volume: 139 Issue: 1 Pages: 48-60
- DOI
  10.1111/imm.12054
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591454
[Presentation] Cellular metabolism of CD4+ CD25+ regulatory T cells is distinct from that of CD4+ CD25- conventional T cells2014
- Author(s)
  Kojima H, Kanno Y, Kashiwakura Y, Hashiguchi M, Kobata T
- Organizer
  第４3回日本免疫学会学術集会
- Place of Presentation
  京都
- Year and Date
  2014-12-12
- Data Source
  KAKENHI-PROJECT-24591454
[Presentation] Glycolysis, that impacts on bone marrow B cell development, dose not have a decisive influence on peripheral B cell differentiation2014
- Author(s)
  Kanno Y, Kashiwakura T, Hashiguchi M, Kobata T, Kojima H
- Organizer
  第４3回日本免疫学会学術集会
- Place of Presentation
  京都
- Year and Date
  2014-12-11
- Data Source
  KAKENHI-PROJECT-24591454
[Presentation] CD2 stimulation upregulates Foxp3 in murine peripheral regulatory T cells2014
- Author(s)
  Kashiwakura Y, Kanno Y, Hashiguchi M, Kobata T, Kojima H
- Organizer
  第４3回日本免疫学会学術集会
- Place of Presentation
  京都
- Year and Date
  2014-12-12
- Data Source
  KAKENHI-PROJECT-24591454
[Presentation] CD2-mediated regulation of peripheral CD4+CD25+ regulatory T cell apoptosis accompanied by down regulation of Bim2013
- Author(s)
  Kashiwakura Y, Sakurai D., Kanno Y, Hashiguchi M, Kobata T, Kojima H.
- Organizer
  第42回日本免疫学会学術集会
- Place of Presentation
  千葉市
- Data Source
  KAKENHI-PROJECT-24591454
[Presentation] HIF-1α is regulated by IL-7 in pro-B cells during B cell development.2013
- Author(s)
  Kanno Y, Kashiwakura T, Hashiguchi M, Kobata T, Kojima H.
- Organizer
  第42回日本免疫学会学術集会
- Place of Presentation
  千葉市
- Data Source
  KAKENHI-PROJECT-24591454
[Presentation] Cytokine-dependent CD4+CD25+ regulatory T cell activation during immune responses2013
- Author(s)
  Kojima H, Kanno Y, Kashiwakura Y, Hashiguchi M, Kobata T.
- Organizer
  第42回日本免疫学会学術集会
- Place of Presentation
  千葉市
- Data Source
  KAKENHI-PROJECT-24591454
[Presentation] TCR-independent CD4+CD25+ regulatory T cell activation during immune responses2013
- Author(s)
  Kojima H, Kashiwakura Y, Hashiguchi M, Kobata T.
- Organizer
  15th international Congress of Immunology
- Place of Presentation
  Milan, Italy
- Data Source
  KAKENHI-PROJECT-24591454
[Presentation] CD2-mediated regulation of peripheral CD4+CD25+ regulatory T cell apoptosis accompanied by downregulation of Bim2013
- Author(s)
  Kashiwakura Y, Sakurai D, Kanno Y, Hashiguchi M, Kobayashi A, Kurosu A, Tokudome S, Kobata T, Kojima H.
- Organizer
  15th international Congress of Immunology
- Place of Presentation
  Milan, Italy
- Data Source
  KAKENHI-PROJECT-24591454
[Presentation] IL-7 is a principal factor for HIF-1α regulated pro-B development
- Author(s)
  Kanno Y, Kashiwakura T, Hashiguchi M, Kobata T, Kojima H.
- Organizer
  第41回日本免疫学会学術集会
- Place of Presentation
  神戸国際会議場（兵庫県神戸市）
- Data Source
  KAKENHI-PROJECT-24591454
[Presentation] Characterization of activated CD4+ CD25+ regulatory T cells during immune responses
- Author(s)
  Kojima H, Kanno Y, Kashiwakura Y, Hashiguchi M, Kobata T.
- Organizer
  第41回日本免疫学会学術集会
- Place of Presentation
  神戸国際会議場（兵庫県神戸市）
- Data Source
  KAKENHI-PROJECT-24591454
[Presentation] Peripheral CD4+ CD25+ regulatory T cell survival is regulated by a combination of CD2 stimuli and the interaction with stromal cells
- Author(s)
  Kashiwakura Y, Kanno Y, Hashiguchi M, Kobata T, Kojima H.
- Organizer
  第41回日本免疫学会学術集会
- Place of Presentation
  神戸国際会議場（兵庫県神戸市）
- Data Source
  KAKENHI-PROJECT-24591454

1. OKUMURA Ko (50009700)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. YAGITA Hideo (30182306)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. HASHIGUCHI Masaaki (20372443)

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results
4. KASHIWAKURA Yuji (40382890)

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results
5. NISHIOKA Kusuki (60049070)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. YUKI Nobuhiro (60285913)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. YAMADA Mitsunori (30240039)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. UEDA Syuichi (60150570)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. KOJIMA Hidefumi (40322408)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. SAKURAI Daisuke (30382964)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 屋部登志雄 (50239836)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 中村哲也 (30189047)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

KOBATA Tetsuji 小端 哲二

OBATA Tetsuji 小端 哲二

Research Projects

Research Products

Co-Researchers

Regulatory roles of HIF-1a and glycolysis in autoimmunityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Synergistic effects of BAFF/BLyS and CD19 on B-cell responses in germinal centersPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Pathogenesis of Guillain-Barre syndrome and Fisher syndromes : evidence of molecular mimicry

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of Fas/FasL interaction in self-tolerance : evaluated by bone marrow transplantationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ヒトT細胞膜抗原10D1の胸線内T細胞分化・活性化における役割の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Immuno-Melecular characterization of lymphocyte functioning antigen (LFA)

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] サイトカイン・増殖因子 用語ライブラリー(菅村和夫, 宮園浩平, 宮澤恵二, 田中伸幸 編)2005

Author(s)

Publisher

Data Source

[Book] サイトカニン・増殖因子 用語ライブラリー(菅村和夫、宮園浩平、宮澤恵ニ、田中伸幸編)2005

Author(s)

Publisher

Description

Data Source

[Journal Article] CD2-mediated regulation of peripheral CD4+CD25+ regulatory T cell apoptosis accompanied with down regulation of Bim2013

Author(s)

Journal Title

DOI

Data Source

[Presentation] Cellular metabolism of CD4+ CD25+ regulatory T cells is distinct from that of CD4+ CD25- conventional T cells2014

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Glycolysis, that impacts on bone marrow B cell development, dose not have a decisive influence on peripheral B cell differentiation2014

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] CD2 stimulation upregulates Foxp3 in murine peripheral regulatory T cells2014

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] CD2-mediated regulation of peripheral CD4+CD25+ regulatory T cell apoptosis accompanied by down regulation of Bim2013

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] HIF-1α is regulated by IL-7 in pro-B cells during B cell development.2013

Author(s)

KOBATA Tetsuji 小端哲二

OBATA Tetsuji 小端哲二

[Book] サイトカイン・増殖因子用語ライブラリー(菅村和夫, 宮園浩平, 宮澤恵二, 田中伸幸編)2005

[Book] サイトカニン・増殖因子用語ライブラリー(菅村和夫、宮園浩平、宮澤恵ニ、田中伸幸編)2005