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EGAWA Tsuyoshi  江川 毅

ORCIDConnect your ORCID iD *help
Researcher Number 10232935
Affiliation (based on the past Project Information) *help 2001 – 2002: 慶應義塾大学, 医学部, 助手
1996: 慶応義塾大学, 医学部, 助手
1993 – 1996: 慶應義塾大学, 医学部, 助手
1993: 慶応義塾大学, 医学部, 助手
Review Section/Research Field
Principal Investigator
Biophysics
Except Principal Investigator
Functional biochemistry / Pathological medical chemistry / Science and Engineering / Biophysics / Biological Sciences
Keywords
Principal Investigator
compound II / compound I / クロロペルオキシダーゼ / ミックスト‐フロー / 共鳴ラマン分光法 / 高酸化ヘム / チトクロームP‐450
Except Principal Investigator
Site-directed mutagenesis / heme oxygenase / シトクロムP450 … More / 部位特異的アミノ酸置換 / soluble guanylate cyclase / nitric oxide / microcirculation / ヘムオキシゲナーゼ / 一酸化窒素 / 一酸化炭素 / P450cam / 人工アミノ酸 / O-O結合開裂反応 / 酸触媒 / 過酸化水素 / ミオグロビン / カンファー / cystathionine β-synthase / knockout mice / carbon monoixde / cystathionine beta synthase / conditional knock out mice / hypoxia / carbon monoxide / heme oxgenase / 胆汁分泌 / cystathionine β synthase / ノックアウト動物 / アミノ酸置換体 / 硫化水素 / シスタチオニン合成酵素 / シスタチオニンベータシンターゼ / 遺伝子改変動物 / 可溶性グアニル酸シクラーゼ / cell-free protein synthesis / membrane protein / proton pump / cytochrome oxidase / myoglobin / heme / gene therapy / composite biocatalyst / 亜硝酸イオン還元酵素 / ペルオキシゲナーゼ / 水素イオン供給 / オーダーメイド / ミトコンドリア / 膜タンパク質複合体 / ペルオキシダーゼ / 亜硝酸還元酵素 / ポルフィセン / 膜たんぱく質複合体 / 無細胞蛋白合成系 / 膜蛋白質 / プロトンポンプ / チトクロム酸化酵素 / ヘム / 遺伝子治療 / コンポジット生体触媒 / oxidative stress / Bile transport / Bilirubin / Liver / Nitric oxide / Carbon monoxide / 酸素ストレス / 胆汁排泄 / ビリルビン / 肝臓 / 微小循環 / Hydrogen bonding / Threonine / Dioxygen-bond cleavage / Artificial amino acids / Acid-base catalyst / Activation of molecular oxygen / Cytochome P450 / スレオニン / 酸素活性化 / ELECTRON TRANSFER / ARTIFICIAL AMINO ACID / O-O BOND CLEAVAGE / ARTIFICIAL ENZYME / ACID CATALYST / OXYGENATEDFORM / CAMPHOR / CYTOCHROME P450 / 非天然型アミノ酸 / プロトン / 電子伝達 / 人工酵素 / 酸素化型 / チトクロームP450 / Oxgen Activation mechanism / NADPH-oxidase / Monooxygenases / Oxygenases / Activated forms of oxygen / Oxygen metabolism / Cytochrome P450 / NADPHオキシダーゼ / NADPHオキシターゼ / 酸素添加酵素 / オキシゲナーゼ / 活性酸素 / 酸素の活性化 / プロトン供給 / X線結晶構造解析 / 水 / アミノ酸置換 / プチダレドキシン / EPR / 水素イオン輸送 / シトクロームP450 Less
  • Research Projects

    (8 results)
  • Research Products

    (5 results)
  • Co-Researchers

    (19 People)
  •  Analysis of molecular mechanisms by which heme oxygenase-carbon monoxide pathway regulates cellular functions under physiological and pathophysiological conditions using newly developed gene targeting mice.

    • Principal Investigator
      SUEMATSU Makoto
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Keio University
  •  カムオペロンの末端酸化酵素と電子供与体たんぱく質の複合体

    • Principal Investigator
      SHIMADA Hideo
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Keio University
  •  Development of heme-based highly efficient biocatalysts

    • Principal Investigator
      SHIMADA Hideo
    • Project Period (FY)
      2001 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Science and Engineering
    • Research Institution
      KEIO UNIVERSITY
  •  CO as a novel signaling molecule modulating cell and organ function.

    • Principal Investigator
      SUEMATSU Makoto
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Institution
      School of Medicine, Keio University
  •  MECHANISM FOR OXYGEN ACTIVATION BY CYTOCHROME P450cam

    • Principal Investigator
      ISHIMURA Yuzuru
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Functional biochemistry
    • Research Institution
      SCHOOL OF MEDICINE,KEIO UNIVERSITY
  •  超微量ミックスト‐フロー=ラマン装置によるチトクロムP‐450中間体の構造決定Principal Investigator

    • Principal Investigator
      江川 毅
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Biophysics
    • Research Institution
      Keio University
  •  Oxygen activation mechanisms in cytochrome P450-and NADPH oxidase-catalyzed reactions

    • Principal Investigator
      ISHIMURA Yuzuru
    • Project Period (FY)
      1993 – 1994
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Functional biochemistry
    • Research Institution
      Keio University
  •  Elucidation for the catalytic function of cytochrome P450cam by site-specific incorporation of natural and unnatural amino acid.

    • Principal Investigator
      SHIMADA Hideo
    • Project Period (FY)
      1993 – 1994
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Biophysics
    • Research Institution
      KEIO UNIVERSITY

All 2003 2002

All Journal Article

  • [Journal Article] Kinetic and spectroscopic characterization of a hydroperoxy compound in the reaction of native myoglobin with hydrogen peroxide.2003

    • Author(s)
      Egawa, T
    • Journal Title

      J Biol Chem 278・43

      Pages: 41597-41606

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370063
  • [Journal Article] Infrared spectroscopic and mutational studies on putidaredoxin-induced conformational changes in ferrous CO-P450cam.2003

    • Author(s)
      Nagano S, Shimada H, Tarumi A, Hishiki T, Kimata-Ariga Y, Egawa T, Suematsu M. Park SY, Adachi S, Shiro Y, Ishimura Y.
    • Journal Title

      Biochemistry 42・49

      Pages: 14507-14514

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370063
  • [Journal Article] Expression of heme oxygenase-1 in rat ontogeny.2003

    • Author(s)
      Watanabe T, Hasegawa G, Yamamoto T, Hatakeyama K, Suematsu M, Naito M.
    • Journal Title

      Arch Histol Cytol 66・2

      Pages: 155-162

    • NAID

      10011992787

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370063
  • [Journal Article] Kinetic and spectroscopic characterization of a hydroperoxy compound in the reaction of native myoglobin with hydrogen peroxide.2003

    • Author(s)
      Egawa T, Yoshioka S, Takahashi S, Hori H, Nagano S, Shimada H, Ishimori K, Morishima I, Suematsu M, Ishimura Y.
    • Journal Title

      J Biol Chem 278・43

      Pages: 41597-41606

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370063
  • [Journal Article] The protective role of Kupffer cells in the ischemia-reperfused rat liver.2002

    • Author(s)
      Kobayashi T, Hirano K, Yamamoto T, Hasegawa G, Hatakeyama K, Suematsu M, Naito M.
    • Journal Title

      Arch Histol Cytol 65・3

      Pages: 251-261

    • NAID

      50000651396

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370063
  • 1.  SHIMADA Hideo (80095611)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 2.  ISHIMURA Yuzuru (40025599)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 3.  HIROSE Tadaaki (60051405)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 4.  MIKI Hideho (90229667)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  MUKAI Kuniaki (80229913)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  SUEMATSU Makoto (00206385)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 4 results
  • 7.  菱木 貴子 (10338022)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 8.  KIMATA Yoko (60255429)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  NAGANO Shingo (60286440)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  WAKABAYASHI Yoshiyuki (10276214)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  FUJII Hiroshi (80228957)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  HAYASHI Takashi (20222226)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  GODA Nobuhito (00245549)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  ONISHI Yasuyuki (70201382)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  堀 洋 (20127294)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  YONETANI Takashi
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  WILSON David F
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  YONETANI Ta
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  WILSON Davi
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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