EGAWA Tsuyoshi 江川毅

Researcher Number	10232935
Affiliation (based on the past Project Information) *help	2001 – 2002: 慶應義塾大学, 医学部, 助手 1996: 慶応義塾大学, 医学部, 助手 1993 – 1996: 慶應義塾大学, 医学部, 助手 1993: 慶応義塾大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Biophysics Except Principal Investigator Functional biochemistry / Pathological medical chemistry / Science and Engineering / Biophysics / Biological Sciences
Keywords	Principal Investigator compound II / compound I / クロロペルオキシダーゼ / ミックスト‐フロー / 共鳴ラマン分光法 / 高酸化ヘム / チトクロームP‐450 Except Principal Investigator Site-directed mutagenesis / heme oxygenase / シトクロムP450 … More / 部位特異的アミノ酸置換 / soluble guanylate cyclase / nitric oxide / microcirculation / ヘムオキシゲナーゼ / 一酸化窒素 / 一酸化炭素 / P450cam / 人工アミノ酸 / O-O結合開裂反応 / 酸触媒 / 過酸化水素 / ミオグロビン / カンファー / cystathionine β-synthase / knockout mice / carbon monoixde / cystathionine beta synthase / conditional knock out mice / hypoxia / carbon monoxide / heme oxgenase / 胆汁分泌 / cystathionine β synthase / ノックアウト動物 / アミノ酸置換体 / 硫化水素 / シスタチオニン合成酵素 / シスタチオニンベータシンターゼ / 遺伝子改変動物 / 可溶性グアニル酸シクラーゼ / cell-free protein synthesis / membrane protein / proton pump / cytochrome oxidase / myoglobin / heme / gene therapy / composite biocatalyst / 亜硝酸イオン還元酵素 / ペルオキシゲナーゼ / 水素イオン供給 / オーダーメイド / ミトコンドリア / 膜タンパク質複合体 / ペルオキシダーゼ / 亜硝酸還元酵素 / ポルフィセン / 膜たんぱく質複合体 / 無細胞蛋白合成系 / 膜蛋白質 / プロトンポンプ / チトクロム酸化酵素 / ヘム / 遺伝子治療 / コンポジット生体触媒 / oxidative stress / Bile transport / Bilirubin / Liver / Nitric oxide / Carbon monoxide / 酸素ストレス / 胆汁排泄 / ビリルビン / 肝臓 / 微小循環 / Hydrogen bonding / Threonine / Dioxygen-bond cleavage / Artificial amino acids / Acid-base catalyst / Activation of molecular oxygen / Cytochome P450 / スレオニン / 酸素活性化 / ELECTRON TRANSFER / ARTIFICIAL AMINO ACID / O-O BOND CLEAVAGE / ARTIFICIAL ENZYME / ACID CATALYST / OXYGENATEDFORM / CAMPHOR / CYTOCHROME P450 / 非天然型アミノ酸 / プロトン / 電子伝達 / 人工酵素 / 酸素化型 / チトクロームP450 / Oxgen Activation mechanism / NADPH-oxidase / Monooxygenases / Oxygenases / Activated forms of oxygen / Oxygen metabolism / Cytochrome P450 / NADPHオキシダーゼ / NADPHオキシターゼ / 酸素添加酵素 / オキシゲナーゼ / 活性酸素 / 酸素の活性化 / プロトン供給 / X線結晶構造解析 / 水 / アミノ酸置換 / プチダレドキシン / EPR / 水素イオン輸送 / シトクロームP450 Less

Analysis of molecular mechanisms by which heme oxygenase-carbon monoxide pathway regulates cellular functions under physiological and pathophysiological conditions using newly developed gene targeting mice.
- Principal Investigator
  
  SUEMATSU Makoto
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Keio University
カムオペロンの末端酸化酵素と電子供与体たんぱく質の複合体
- Principal Investigator
  
  SHIMADA Hideo
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Keio University
Development of heme-based highly efficient biocatalysts
- Principal Investigator
  
  SHIMADA Hideo
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  KEIO UNIVERSITY
CO as a novel signaling molecule modulating cell and organ function.
- Principal Investigator
  
  SUEMATSU Makoto
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  School of Medicine, Keio University
MECHANISM FOR OXYGEN ACTIVATION BY CYTOCHROME P450cam
- Principal Investigator
  
  ISHIMURA Yuzuru
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  SCHOOL OF MEDICINE,KEIO UNIVERSITY
超微量ミックスト‐フロー=ラマン装置によるチトクロムP‐450中間体の構造決定Principal Investigator
- Principal Investigator
  
  江川毅
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Biophysics
- Research Institution
  Keio University
Oxygen activation mechanisms in cytochrome P450-and NADPH oxidase-catalyzed reactions
- Principal Investigator
  
  ISHIMURA Yuzuru
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  Keio University
Elucidation for the catalytic function of cytochrome P450cam by site-specific incorporation of natural and unnatural amino acid.
- Principal Investigator
  
  SHIMADA Hideo
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Biophysics
- Research Institution
  KEIO UNIVERSITY

All 2003 2002

All Journal Article

[Journal Article] Kinetic and spectroscopic characterization of a hydroperoxy compound in the reaction of native myoglobin with hydrogen peroxide.2003
- Author(s)
  Egawa, T
- Journal Title
  
  J Biol Chem 278・43
  
  Pages: 41597-41606
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370063
[Journal Article] Infrared spectroscopic and mutational studies on putidaredoxin-induced conformational changes in ferrous CO-P450cam.2003
- Author(s)
  Nagano S, Shimada H, Tarumi A, Hishiki T, Kimata-Ariga Y, Egawa T, Suematsu M. Park SY, Adachi S, Shiro Y, Ishimura Y.
- Journal Title
  
  Biochemistry 42・49
  
  Pages: 14507-14514
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370063
[Journal Article] Expression of heme oxygenase-1 in rat ontogeny.2003
- Author(s)
  Watanabe T, Hasegawa G, Yamamoto T, Hatakeyama K, Suematsu M, Naito M.
- Journal Title
  
  Arch Histol Cytol 66・2
  
  Pages: 155-162
- NAID
  10011992787
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370063
[Journal Article] Kinetic and spectroscopic characterization of a hydroperoxy compound in the reaction of native myoglobin with hydrogen peroxide.2003
- Author(s)
  Egawa T, Yoshioka S, Takahashi S, Hori H, Nagano S, Shimada H, Ishimori K, Morishima I, Suematsu M, Ishimura Y.
- Journal Title
  
  J Biol Chem 278・43
  
  Pages: 41597-41606
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370063
[Journal Article] The protective role of Kupffer cells in the ischemia-reperfused rat liver.2002
- Author(s)
  Kobayashi T, Hirano K, Yamamoto T, Hasegawa G, Hatakeyama K, Suematsu M, Naito M.
- Journal Title
  
  Arch Histol Cytol 65・3
  
  Pages: 251-261
- NAID
  50000651396
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370063

1. SHIMADA Hideo (80095611)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
2. ISHIMURA Yuzuru (40025599)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. HIROSE Tadaaki (60051405)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. MIKI Hideho (90229667)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. MUKAI Kuniaki (80229913)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. SUEMATSU Makoto (00206385)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
7. 菱木貴子 (10338022)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. KIMATA Yoko (60255429)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. NAGANO Shingo (60286440)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. WAKABAYASHI Yoshiyuki (10276214)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. FUJII Hiroshi (80228957)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. HAYASHI Takashi (20222226)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. GODA Nobuhito (00245549)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. ONISHI Yasuyuki (70201382)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 堀洋 (20127294)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. YONETANI Takashi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. WILSON David F

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. YONETANI Ta

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. WILSON Davi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

EGAWA Tsuyoshi 江川 毅

Research Projects

Research Products

Co-Researchers

Analysis of molecular mechanisms by which heme oxygenase-carbon monoxide pathway regulates cellular functions under physiological and pathophysiological conditions using newly developed gene targeting mice.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

カムオペロンの末端酸化酵素と電子供与体たんぱく質の複合体

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of heme-based highly efficient biocatalysts

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

CO as a novel signaling molecule modulating cell and organ function.

Principal Investigator

Project Period (FY)

Research Category

Research Institution

MECHANISM FOR OXYGEN ACTIVATION BY CYTOCHROME P450cam

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

超微量ミックスト‐フロー=ラマン装置によるチトクロムP‐450中間体の構造決定Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Oxygen activation mechanisms in cytochrome P450-and NADPH oxidase-catalyzed reactions

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation for the catalytic function of cytochrome P450cam by site-specific incorporation of natural and unnatural amino acid.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Kinetic and spectroscopic characterization of a hydroperoxy compound in the reaction of native myoglobin with hydrogen peroxide.2003

Author(s)

Journal Title

Description

Data Source

[Journal Article] Infrared spectroscopic and mutational studies on putidaredoxin-induced conformational changes in ferrous CO-P450cam.2003

Author(s)

Journal Title

Description

Data Source

[Journal Article] Expression of heme oxygenase-1 in rat ontogeny.2003

Author(s)

Journal Title

NAID

Description

Data Source

[Journal Article] Kinetic and spectroscopic characterization of a hydroperoxy compound in the reaction of native myoglobin with hydrogen peroxide.2003

Author(s)

Journal Title

Description

Data Source

[Journal Article] The protective role of Kupffer cells in the ischemia-reperfused rat liver.2002

Author(s)

Journal Title

NAID

Description

Data Source

EGAWA Tsuyoshi 江川毅