yamada hidekazu 山田秀和

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YAMADA Hidekazu 山田秀和

山田秀和ヤマダヒデカズ

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Researcher Number	10254012
Affiliation (Current)	2025: 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん薬物療法研究部, 特任研究員
Affiliation (based on the past Project Information) *help	2016 – 2024: 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん薬物療法研究部, 特任研究員 1995: 福島県立医科大学, 医学部, 助手 1994: 福島県立医科大学, 医学部・産婦人科, 助手
Review Section/Research Field	Principal Investigator Basic Section 56040:Obstetrics and gynecology-related / Obstetrics and gynecology / Obstetrics and gynecology
Keywords	Principal Investigator 卵巣がん / 標的治療 / 代謝 / DNA修復 / BRCA / 治療 / 鉄硫黄クラスター / 婦人科腫瘍学 / プロテインホスファターゼ / 卵巣癌 / BRCA1 / 胎盤 / VEGF

卵巣がんの鉄・硫黄代謝を標的とする新規ターゲット治療の開発Principal Investigator
- Principal Investigator
  
  山田秀和
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Miyagi Prefectural Hospital Organization Miyagi Cancer Center
Targeting metabolic vulnerability of ovarian cancerPrincipal Investigator
- Principal Investigator
  
  Yamada Hidekazu
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Miyagi Prefectural Hospital Organization Miyagi Cancer Center
Metabolisms in BRCA-deficient and -proficient ovarian cancer as new therapeutic and diagnostic target.Principal Investigator
- Principal Investigator
  
  Yamada Hidekazu
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Miyagi Prefectural Hospital Organization Miyagi Cancer Center
Insufficiency of a novel anti-oncogene and mouse ovarian tumorigenesisPrincipal Investigator
- Principal Investigator
  
  YAMADA Hidekazu
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Miyagi Prefectural Hospital Organization Miyagi Cancer Center
卵巣癌の発症進展におけるBRCA-1の関年に関する研究Principal Investigator
- Principal Investigator
  
  山田秀和
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Fukushima Medical University
胎盤形成のメカニズムの解明-特に血管新生の面から-Principal Investigator
- Principal Investigator
  
  山田秀和
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Fukushima Medical University

All 2023 2022 2020 2019 2018 2017 2016

All Journal Article Presentation

[Journal Article] Niacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma.2023
- Author(s)
  Nomura M, Ohuchi M, Sakamoto Y, Kudo K, Yaku K, Soga T, Sugiura Y, Morita M, Hayashi K, Miyahara S, Sato T, Yamashita Y, Ito S, Kikuchi N, Sato I, Saito R, Yaegashi N, Fukuhara T, Yamada H, Shima H, Nakayama KI, Hirao A, Kawasaki K, Arai Y, Akamatsu S, Tanuma S, Sato T, Nakagawa T and Tanuma N.
- Journal Title
  
  Nature Communications.
  
  Volume: 14(1) Issue: 1 Pages: 8095-8095
- DOI
  10.1038/s41467-023-43630-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09482, KAKENHI-PROJECT-21K11593, KAKENHI-ORGANIZER-23H04939, KAKENHI-PROJECT-22H04995, KAKENHI-PROJECT-23K24762, KAKENHI-PROJECT-23K27437
[Journal Article] Japan Society of Gynecologic Oncology 2018 guidelines for treatment of uterine body neoplasms.2020
- Author(s)
  Yamagami W, Mikami M, Nagase S, Tabata T, Kobayashi Y, Kaneuchi M, Kobayashi H, Yamada H, Hasegawa K, Fujiwara H, Katabuchi H, Aoki D.
- Journal Title
  
  J Gynecol Oncol
  
  Volume: 31(1) Issue: 1
- DOI
  10.3802/jgo.2020.31.e18
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H04340, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-20H03828, KAKENHI-PROJECT-18K09243
[Journal Article] Divergent metabolic responses dictate vulnerability to NAMPT inhibition in ovarian cancer2020
- Author(s)
  Kudo Kei、Nomura Miyuki、Sakamoto Yoshimi、Ito Shigemi、Morita Mami、Kawai Masaaki、Yamashita Yoji、Ito Kiyoshi、Yamada Hidekazu、Shima Hiroshi、Yaegashi Nobuo、Tanuma Nobuhiro
- Journal Title
  
  FEBS Letters
  
  Volume: 594 Issue: 9 Pages: 1379-1388
- DOI
  10.1002/1873-3468.13736
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K09469, KAKENHI-PROJECT-17K07187, KAKENHI-PROJECT-19K09109, KAKENHI-PROJECT-18K09243, KAKENHI-PROJECT-17K07231, KAKENHI-PROJECT-18K15965
[Journal Article] Pelvic Exenteration as Potential Cure and Symptom Relief in Advanced and Recurrent Gynaecological Cancer2019
- Author(s)
  SOEDA SHU、FURUKAWA SHIGENORI、SATO TETSU、UEDA MAKIKO、KAMO NORIHIRO、ENDO YUTA、KOJIMA MANABU、NOMURA SHINZI、KATAOKA MASAO、FUJITA SHOTARO、ENDO HISAHITO、TAKAHASHI TOSHIFUMI、WATANABE TAKAFUMI、YAMADA HIDEKAZU、FUJIMORI KEIYA
- Journal Title
  
  Anticancer Research
  
  Volume: 39 Issue: 10 Pages: 5631-5637
- DOI
  10.21873/anticanres.13759
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K09243
[Journal Article] Clinical and reproductive outcomes of fertility?sparing surgery in stage?I epithelial ovarian cancer2019
- Author(s)
  Watanabe Takafumi、Soeda Shu、Nishiyama Hiroshi、Kiko Yuichiroh、Tokunaga Hideki、Shigeta Shogo、Yaegashi Nobuo、Yamada Hidekazu、Ohta Tsuyoshi、Nagase Satoru、Shoji Tadahiro、Kagabu Masahiro、Baba Tsukasa、Shimizu Dai、Sato Naoki、Terada Yukihiro、Futagami Masayuki、Yokoyama Yoshihito、Fujimori Keiya
- Journal Title
  
  Molecular and Clinical Oncology
  
  Volume: 12 Pages: 44-50
- DOI
  10.3892/mco.2019.1954
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K09243
[Journal Article] Clinicopathologic features and BRCA mutations in primary fallopian tube cancer in Japanese women2018
- Author(s)
  Sakurada Shoko、Watanabe Yoh、Tokunaga Hideki、Takahashi Fumiaki、Yamada Hidekazu、Takehara Kazuhiro、Yaegashi Nobuo
- Journal Title
  
  Japanese Journal of Clinical Oncology
  
  Volume: 48 Issue: 9 Pages: 794-798
- DOI
  10.1093/jjco/hyy095
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K09243
[Journal Article] Loss of protein phosphatase 6 in mouse keratinocytes enhances K-ras G12D -driven tumor promotion2018
- Author(s)
  Kurosawa Koreyuki、Inoue Yui、Kakugawa Yoichiro、Yamashita Yoji、Kanazawa Kosuke、Kishimoto Kazuhiro、Nomura Miyuki、Momoi Yuki、Sato Ikuro、Chiba Natsuko、Suzuki Mai、Ogoh Honami、Yamada Hidekazu、Miura Koh、Watanabe Toshio、Tanuma Nobuhiro、Tachi Masahiro、Shima Hiroshi
- Journal Title
  
  Cancer Science
  
  Volume: 109 Issue: 7 Pages: 2178-2187
- DOI
  10.1111/cas.13638
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07187, KAKENHI-PROJECT-17K10660, KAKENHI-PROJECT-18K16043, KAKENHI-PROJECT-16H04690, KAKENHI-PROJECT-16K07296, KAKENHI-PROJECT-16K10486, KAKENHI-PROJECT-16K10774, KAKENHI-PROJECT-17K16358, KAKENHI-PROJECT-17K16876, KAKENHI-PROJECT-18K09243, KAKENHI-PROJECT-16K07187, KAKENHI-PROJECT-17K19620
[Journal Article] Loss of protein phosphatase 6 in mouse keratinocytes enhances K-rasG12D-driven tumor promotion.2018
- Author(s)
  Kurosawa K, Inoue Y, Kakugawa Y, Yamashita Y, Kanazawa K, Kishimoto K, Nomura M, Momoi Y, Sato I, Chiba N, Suzuki M, Ogoh H, Yamada H, Miura K, Watanabe T, Tanuma N, Tachi M, and Shima H
- Journal Title
  
  Cancer Science
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K15714
[Journal Article] Current Status of Uterine Leiomyosarcoma in the Tohoku Region: Results of the Tohoku Translational Center Development Network Survey2017
- Author(s)
  Tokunaga H, Takahashi F, Yamamoto H, Honda T, Watanabe T, Shoji T, Sugiyama T, Yamada H, Tando T, Yoshinaga K, Kagabu S, Otsuki T, Kin S, Yokoyama Y, Wagatsuma S, Sato K, Sato H, Oishi T, Yoshida Y, Hayasaka T, Matsui T, Imai N, Nishigori H, Shimokawa H, Yaegashi N, Watanabe Y.
- Journal Title
  
  International Journal of Clinical Oncology
  
  Volume: 22 Issue: 3 Pages: 541-547
- DOI
  10.1007/s10147-017-1097-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K15714
[Journal Article] Clinical efficacy of nedaplatin based concurrent chemoradiotherapy for uterine cervical cancer2016
- Author(s)
  Kagabu M, Shoji T , Murakami K, Omi H, Honda T, Miura F, Yokoyama Y, Tokunaga H,Takano T, Ohta T , Shimizu D & Sato N, Soeda S , Watanabe T, Yamada H, Mizunuma H, Yaegashi N Nagase S,Tase T, Sugiyama T
- Journal Title
  
  a Tohoku Gynecologic Cancer Unit Study. Int J Clin Oncol
  
  Volume: 21（4） Issue: 4 Pages: 735-740
- DOI
  10.1007/s10147-016-0946-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K15714
[Presentation] 鉄硫黄クラスター生合成欠損で腫瘍細胞に誘導された、細胞老化様の増殖停止2023
- Author(s)
  宮原周子、野村美有樹、大内麻衣、山田秀和、田沼延公
- Organizer
  日本生化学会東北支部第89回例会・シンポジウム
- Data Source
  KAKENHI-PROJECT-21K09482
[Presentation] 鉄硫黄クラスター生合成に異常をきたした細胞の表現型2023
- Author(s)
  宮原周子、野村美有樹、大内麻衣、林佳代子、山下洋二、徳永英樹、島田宗昭、山田秀和、田沼延公
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21K09482
[Presentation] CRISPRスクリーニングによる、卵巣癌代謝ターゲットの探索2023
- Author(s)
  宮原周子、徳永英樹、島田宗昭、山田秀和、八重樫伸生、田沼延公
- Organizer
  第65回日本婦人科腫瘍学会学術講演会
- Data Source
  KAKENHI-PROJECT-21K09482
[Presentation] FDX2欠損は卵巣がん細胞株に細胞老化様の増殖停止または細胞死をもたらす2023
- Author(s)
  宮原周子、大内麻衣、野村美有樹、橋本栄文、山下洋二、徳永英樹、島田宗昭、山田秀和、八重樫伸生、田沼延公
- Organizer
  第22回日本婦人科がん分子標的研究会
- Data Source
  KAKENHI-PROJECT-21K09482
[Presentation] 鉄硫黄クラスター欠損が卵巣癌細胞株にもたらす、細胞老化様の増殖停止2023
- Author(s)
  宮原周子、大内麻衣、野村美有樹、山田秀和、田沼延公
- Organizer
  第9回がんと代謝研究会2023 in 松山
- Data Source
  KAKENHI-PROJECT-21K09482
[Presentation] Restriction of the dietary niacin enhances NAD-targeting therapy in mice2022
- Author(s)
  Miyuki Nomura, Tomoyoshi Soga, Shusuke Akamatsu, Mami Morita, Yoji Yamashita, Hiroshi Shima, Hidekazu Yamada, Taku Sato, Nobuhiro Tanuma
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K09482
[Presentation] NAD dependence of small-cell lung and prostate cancers2022
- Author(s)
  Nobuhiro Tanuma, Shuko Miya-hara, Miyuki Nomura, Tomoyoshi Soga, Shusuke Akamatsu, Mami Morita, Yoji Yamashita, Hiroshi Shima, Hidekazu Yamada, Taku Sato,
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K09482
[Presentation] 放射線治療後に局所に病巣が残存した子宮頸癌に対する子宮全摘は有効か？2016
- Author(s)
  山田秀和、藤田信弘、大友圭子、田勢　亨
- Organizer
  第３９回日本産婦人科手術学会
- Place of Presentation
  宮城県・仙台市
- Year and Date
  2016-11-12
- Data Source
  KAKENHI-PROJECT-16K15714

1. 田沼延公 (40333645)

# of Collaborated Projects: 3 results

# of Collaborated Products: 9 results
2. 島礼 (10196462)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
3. 伊藤しげみ (80600006)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 佐藤郁郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 三上幹男

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 山下洋二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

yamada hidekazu 山田 秀和

YAMADA Hidekazu 山田 秀和

山田 秀和 ヤマダ ヒデカズ

Research Projects

Research Products

Co-Researchers

卵巣がんの鉄・硫黄代謝を標的とする新規ターゲット治療の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Targeting metabolic vulnerability of ovarian cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Metabolisms in BRCA-deficient and -proficient ovarian cancer as new therapeutic and diagnostic target.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Insufficiency of a novel anti-oncogene and mouse ovarian tumorigenesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

卵巣癌の発症進展におけるBRCA-1の関年に関する研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

胎盤形成のメカニズムの解明-特に血管新生の面から-Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Niacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Japan Society of Gynecologic Oncology 2018 guidelines for treatment of uterine body neoplasms.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Divergent metabolic responses dictate vulnerability to NAMPT inhibition in ovarian cancer2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Pelvic Exenteration as Potential Cure and Symptom Relief in Advanced and Recurrent Gynaecological Cancer2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Clinical and reproductive outcomes of fertility?sparing surgery in stage?I epithelial ovarian cancer2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Clinicopathologic features and BRCA mutations in primary fallopian tube cancer in Japanese women2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Loss of protein phosphatase 6 in mouse keratinocytes enhances K-ras G12D -driven tumor promotion2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Loss of protein phosphatase 6 in mouse keratinocytes enhances K-rasG12D-driven tumor promotion.2018

Author(s)

Journal Title

yamada hidekazu 山田秀和

YAMADA Hidekazu 山田秀和

山田秀和ヤマダヒデカズ