SHIMA Hiroshi 島礼

… Alternative Names

島礼シマヒロシ

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Researcher Number	10196462
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2011 – 2023: 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん薬物療法研究部, 部長 2017: 宮城県立がんセンター研究所, 所長 2013: 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん薬物療法研究部, 部長 2013: 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん薬物療法研究部, 部長 2012: 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), その他部局等, 部長 … More 2012: 宮城県立がんセンター(研究所), がん薬物療法研究部, 部長 2011: 宮城県立がんセンター(研究所), 薬物療法学部, 学部長 2005 – 2010: 宮城県立がんセンター(研究所), 薬物療法学部, 部長 2008 – 2009: Miyagi Cancer Center Research Institute, 薬物療法学部, 部長 2005: 北大, 遺伝子病制御研究所, 助教授 2005: MIYAGI CANCER CENT.RES.INST., CHIEF, 研究所, 部長 2000 – 2004: 北海道大学, 遺伝子病制御研究所, 助教授 1999: 北海道大学, 免疫科学研究所, 助教授 1993 – 1994: 国立がんセンター, 研究所, 室長 1992: 国立がんセンター研究所, 室長 Less
Review Section/Research Field	Principal Investigator Functional biochemistry / Functional biochemistry / Tumor biology / Biological Sciences / Pathological medical chemistry Except Principal Investigator General surgery / Cerebral neurosurgery / Functional biochemistry / Digestive surgery / Thoracic surgery … More / Basic Section 49030:Experimental pathology-related / Basic Section 55040:Respiratory surgery-related / Basic Section 55010:General surgery and pediatric surgery-related / Medium-sized Section 50:Oncology and related fields / Functional biochemistry / Obstetrics and gynecology / Neurosurgery Less
Keywords	Principal Investigator PP1 / PP2A / プロテインホスファターゼ / MAPK / ホスファターゼ / S6キナーゼ / MKP7 / LDP4 / pp32 / 翻訳 … More / SET / I-2^<PP2A> / I-1^<PP2A> / TCPTP / Aurora kinase / GSK3β / tautomycetin / phosphatase / kinase / phosphorylation / 細胞増殖 / キナーゼ / リン酸化 / S6 / PP6 / 癌 / スプライシング / NIPP1 / LDP / がん化 / 細胞周期 / 欠損マウス / カルシニューリン / 発がん / メラノーマ / 皮膚がん / プロモーション / イニシエーション / セリン・スレオニンプロテインホスファターゼ6型 / Kras / siRNA / 浸透圧刺激 / ユビキチン / MAPKホスファターゼ / 中心体 / ビメンチン / 阻害剤 / manzamenone / PTP1B / T-cell PTP / オーロラキナーゼ / MARK / dephosphorylation / gsk3b / raf / トウトマイセチン / 脱リン酸化 / calcineurin / 免疫抑制 / 癌化 / トウトマイシン / トートマイセチン / ドライバー変異 / ゲノム不安定性 / DNA修復 / 炎症 / 2重基質ボスファターゼ / 2重基質ホスファターゼ / ２重基質ホスファターゼ / KIF3 / キネシンモーター / 分子腫瘍学 / ERK / 中心体制御 / β-catenin / N-Cadherin / KIF3A / Dusp26 / 細胞死 / モータータンパク / 細胞間接着 / DUSP26 / SAP155 / mRNA / クロマチンリモデリング活性 / 結合蛋白 / クロマチン免疫沈降法 / FHAドメイン / 転写 / 肝がん / シャトルタンパク / NES / MKP / デュアルホスファターゼ / 二重基質特異性ホスファターゼ / NIPP-1 / アポトーシス / 活性測定法 / 免疫抑制薬 / ノックアウトマウス … More Except Principal Investigator プロテインホスファターゼ / 代謝 / ワールブルグ効果 / チロシンホスファターゼ / PTPεC / 乳がん / 化学療法 / 肺癌 / スプライシング / 癌形質 / 発癌 / スレオニンホスファターゼ / セリン / 細胞老化 / JNK / siRNA / Raf-1 / LDP-3 / MKP-7 / NIPP-1 / PP1 / IL-6 / トウトマイセチン / PTPε / がん / 大腸がん / 低酸素 / PP6 / PKM / 解糖系酵素 / 解糖系 / 肺がん / 脳腫瘍学 / 遺伝子発現異常 / 呼吸器外科学 / 遺伝子発現 / 細胞増殖 / 細胞周期 / Trp53 / Kras / 膵がん / KRAS / マウス発がん実験 / 舌癌 / 肺扁平上皮癌 / 放射線療法 / がんターゲット治療 / ユビキチン化 / Cdc25B / Cdc25A / プロテインホスファターセ / タンパク質分解 / 脱リン酸化 / リン酸化 / タンパク質安定化 / 婦人科腫瘍学 / 卵巣がん / CDC25A / glioma / プロテインホスファターゼ6型 / 悪性グリオーマ / 乳腺外科学 / 治療抵抗性 / 補助療法 / 実験外科学 / 紫外線発がん / LDP / ストレス応答 / M1細胞 / ERK / トートマイセチン / JNKホスファターゼ / Raf / インヒビター2 / B-Raf / DSP / apoptosis / cell differentiation / tautomycetin / dual specificity phosphatase / phosphotyrosine phosphatase / protein phosphatase / 2重特異性ホスファターゼ / 癌化 / トウトマイシン / インヒビター4 / 2重基質特異性ホスファタ-ゼ / セリンホスファタ-ゼ / チロシンホスファタ-ゼ / アポトーシス / 細胞分化 / 二重基質特異性ホスファターゼ / ゲノム不安定性 / 低栄養 / DNA修復 / SNP / BRCA１ / PP６ / HER２ / SNPs / BRCA1 / ノックアウトマウス / ホスファターゼ / HER2 / 腫瘍マーカー / グリオーマ / モノクロナル抗体 / FDG-PET / 非小細胞肺がん / 中枢神経系リンパ腫 / CDR3 / 免疫グロブリン / 中枢リンパ球系リンパ腫 / 組織バンク / HRM / 早期肺癌 / 前癌病変 / 遺伝子変異 / MAPK経路 / KIF3モーター / 細胞内トランスポート / 蛋白脱リン酸 / 蛋白脱リン後 / イソホーム / 再生肝 Less

Identification of cancer suppressor genes that suppress tumorigenesis by mutant KRAS- involvement in pancreatic cancer
- Principal Investigator
  
  Sato Ikurou
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Miyagi Prefectural Hospital Organization Miyagi Cancer Center
The yin and yang of the Warburg effect of tumors.
- Principal Investigator
  
  Tanuma Nobuhiro
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 50:Oncology and related fields
- Research Institution
  Miyagi Prefectural Hospital Organization Miyagi Cancer Center
Therapy-induced rewiring of metabolism and elaboration of the adjuvant therapy in breast cancer.
- Principal Investigator
  
  Kawai Masaaki
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Miyagi Prefectural Hospital Organization Miyagi Cancer Center
Development of a new therapy to target CD271-positive cancer cells in patients with lung squamous cell carcinoma
- Principal Investigator
  
  Abe Jiro
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  Miyagi Prefectural Hospital Organization Miyagi Cancer Center
Tumorigenesis due to dysfunction of PP6, a novel target for cancer treatment.Principal Investigator
- Principal Investigator
  
  Shima Hiroshi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor biology
- Research Institution
  Miyagi Prefectural Hospital Organization Miyagi Cancer Center
Cellular senescence induced by chemo/radio-therapy as new therapeutic opportunity of mammary tumors.
- Principal Investigator
  
  Kawai Masaaki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Miyagi Prefectural Hospital Organization Miyagi Cancer Center
Identification of a protein phosphatase which involved in brain tumororigenesis.
- Principal Investigator
  
  Yamashita Yoji
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurosurgery
- Research Institution
  Miyagi Prefectural Hospital Organization Miyagi Cancer Center
Insufficiency of a novel anti-oncogene and mouse ovarian tumorigenesis
- Principal Investigator
  
  YAMADA Hidekazu
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Miyagi Prefectural Hospital Organization Miyagi Cancer Center
PP6 as a tumor suppressor in mouse two-stage chemical carcinogenesis
- Principal Investigator
  
  KAKUGAWA Yoichiro
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Miyagi Prefectural Hospital Organization Miyagi Cancer Center
Identification of the responsible PPase that stabilyze cell cycle regulator Cdc25B
- Principal Investigator
  
  Yamashita Katsumi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  Kanazawa University
Tumor promotion associated with Ppp6c-deficiency.Principal Investigator
- Principal Investigator
  
  SHIMA Hiroshi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor biology
- Research Institution
  Miyagi Prefectural Hospital Organization Miyagi Cancer Center
Possible interplay between metabolism and genomic instability during epithelial oncogenesis
- Principal Investigator
  
  SHIIBA KENICHI
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Digestive surgery
- Research Institution
  Miyagi Prefectural Hospital Organization Miyagi Cancer Center
Phosphatome - targeted therapy for breast cancer
- Principal Investigator
  
  KAKUGAWA YOICHIRO
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Miyagi Prefectural Hospital Organization Miyagi Cancer Center
Possible interdependence between Warburg effect and genomic instability during colorectal cancer development
- Principal Investigator
  
  SHIIBA KENITI
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Digestive surgery
- Research Institution
  地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所)
Development of a novel therapy by targeting Warburg effect of gliomas.
- Principal Investigator
  
  YAMASHITA YOUZI
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Miyagi Cancer Center Research Institute
Aberrant pre-mRNA splicinginvolved in increased fluxof glycolysis in non-small lung cancer
- Principal Investigator
  
  SATO Masami
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Thoracic surgery
- Research Institution
  Kagoshima University
Regulation of KIF3 motor by dephosphorylationPrincipal Investigator
- Principal Investigator
  
  SHIMA Hiroshi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Miyagi Cancer Center Research Institute
Therapeutic effect of the polymeric micellar antineoplastic drugs infused convection-enhanced delivery against intracranial rat glioma models
- Principal Investigator
  
  YAMASHITA Yoji
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Miyagi Cancer Center Research Institute
中枢神経系悪性リンパ腫の発生機序に関する研究
- Principal Investigator
  
  片倉隆一
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Miyagi Cancer Center Research Institute
Development of genetic diagnosis and drugs for lung cancer, based on protein phosphatase targeting
- Principal Investigator
  
  SATO Masami
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Thoracic surgery
- Research Institution
  Miyagi Cancer Center Research Institute
Regulation of cell function by protein phosphatasesPrincipal Investigator
- Principal Investigator
  
  SHIMA Hiroshi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  Miyagi Cancer Center Research Institute
mRNA翻訳効率に対する転写過程での刷り込み現象Principal Investigator
- Principal Investigator
  
  島礼
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Functional biochemistry
- Research Institution
  Miyagi Cancer Center Research Institute
Regulation of cell function by protein dephosphorylationPrincipal Investigator
- Principal Investigator
  
  SHIMA Hiroshi
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  Miyagi Cancer Center Research Institute
  Hokkaido University
Molecular mechanisms and their significance of protein phosphatase families which control the network-system of signal transduction
- Principal Investigator
  
  KIKUCHI Kunimi
- Project Period (FY)
  2002 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  HOKKAIDO UNIVERSITY
Regulation of translation by protein phosphorylation.Principal Investigator
- Principal Investigator
  
  SHIMA Hiroshi
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  HOKKAIDO UNIVERSITY
2重特異性ホスファターゼによる細胞増殖の制御・その破綻による制御異常の解析Principal Investigator
- Principal Investigator
  
  島礼
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Hokkaido University
S6キナーゼを中心とする翻訳制御の細胞増殖,発がんにおける関与Principal Investigator
- Principal Investigator
  
  島礼
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Hokkaido University
Regulatgion of translation by protein phosphorylation.Principal Investigator
- Principal Investigator
  
  SHIMA Hiroshi
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  HOKKAIDO UNIVERSITY
Tリンパ球におけるS6キナーゼの機能とその制御機構の研究Principal Investigator
- Principal Investigator
  
  島礼
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Hokkaido University
Studies on control mechanism of protein phosphatases ds a network system of information
- Principal Investigator
  
  KIKUCHI Kunimi
- Project Period (FY)
  1998 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  HOKKAIDO UNIVERSITY
発癌過程ならびに癌細胞形質の発現におけるプロテインホスファターゼの意義
- Principal Investigator
  
  菊地九二三
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hokkaido University
発癌過程ならびに癌細胞形質の発現におけるプロテインホスファターゼの意義
- Principal Investigator
  
  菊池九二三
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Hokkaido University
発癌過程ならびに癌細胞形質の発現におけるプロテインホスファターゼの意義
- Principal Investigator
  
  KIKUCHI Kunimi
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Hokkaido University

[Book] 細胞工学「ホスファターゼ研究新章」2011
- Author(s)
  島礼
- Total Pages
  2
- Publisher
  秀潤社
- Data Source
  KAKENHI-PROJECT-22590298
[Book] 生化学2005
- Author(s)
  島礼
- Total Pages
  8
- Publisher
  生化学会
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16370055
[Book] 生化学2005
- Author(s)
  島礼
- Total Pages
  8
- Publisher
  生化学会
- Data Source
  KAKENHI-PROJECT-17657040
[Book] 細胞工学2003
- Author(s)
  島礼
- Total Pages
  4
- Publisher
  秀潤社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16370055
[Journal Article] Clinical and genomic features of non‐small cell lung cancer occurring in families2023
- Author(s)
  Miyabe Shingo、Ito Shin、Sato Ikuro、Abe Jiro、Tamai Keiichi、Mochizuki Mai、Fujimori Haruna、Yamaguchi Kazunori、Shindo Norihisa、Shima Hiroshi、Yamazaki Tomoko、Abue Makoto、Okada Yoshinori、Yasuda Jun
- Journal Title
  
  Thoracic Cancer
  
  Volume: 14 Issue: 10 Pages: 940-952
- DOI
  10.1111/1759-7714.14825
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07111, KAKENHI-PROJECT-21K07137, KAKENHI-PROJECT-22K07313, KAKENHI-PROJECT-21K15495, KAKENHI-PROJECT-19K16816, KAKENHI-PROJECT-21K09665, KAKENHI-PROJECT-19K09295, KAKENHI-PROJECT-20K17068
[Journal Article] PP6 deficiency in mice with KRAS mutation and Trp53 loss promotes early death by PDAC with cachexia-like features.2022
- Author(s)
  Fukui K, Nomura M, Kishimoto K, Tanuma N, Kurosawa K, Kanazawa K, Kato H, Sato T, Miura S, Miura K, Sato I, Tsuji H, Yamashita Y, Tamai K, Watanabe T, Yasuda J, Tanaka T, Satoh K, Furukawa T, Jingu K, Shima H.
- Journal Title
  
  Cancer Sci.
  
  Volume: 印刷中 Issue: 5 Pages: 1613-1624
- DOI
  10.1111/cas.15315
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09469, KAKENHI-PROJECT-20K06545, KAKENHI-PROJECT-21K19420, KAKENHI-PROJECT-21K19748, KAKENHI-PROJECT-21K07111, KAKENHI-PROJECT-20K07436, KAKENHI-PROJECT-21K15425, KAKENHI-PROJECT-21K16852
[Journal Article] Bird's eye view analysis of in situ cholesterol metabolic pathways in breast cancer patients and its clinicopathological significance in their subtypes.2022
- Author(s)
  Kosaka S, Miyashita M, McNamala K, Nomura M, Shima H, Kawai M, Sato I, Harada-Shoji N, Ishida T, Choi MH, Sasano H
- Journal Title
  
  J Steroid Biochem Mol Biol
  
  Volume: 印刷中 Pages: 106103-106103
- DOI
  10.1016/j.jsbmb.2022.106103
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09109, KAKENHI-PROJECT-22K08688
[Journal Article] Ppp6c deficiency accelerates K-rasG12D -induced tongue carcinogenesis.2021
- Author(s)
  Kishimoto K, Kanazawa K, Nomura M, Tanaka T, Shigemoto-Kuroda T, Fukui K, Miura K, Kurosawa K, Kawai M, Kato H, Terasaki K, Sakamoto Y, Yamashita Y, Sato I, Tanuma N, Tamai K, Kitabayashi I, Matsuura K, Watanabe T, Yasuda J, Tsuji H, Shima H.
- Journal Title
  
  Cancer Med.
  
  Volume: 10(13) Issue: 13 Pages: 4451-4464
- DOI
  10.1002/cam4.3962
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09109, KAKENHI-PROJECT-20K17365, KAKENHI-PROJECT-20K06545, KAKENHI-PROJECT-20K07436, KAKENHI-PROJECT-21K19420, KAKENHI-PROJECT-21K19748, KAKENHI-PROJECT-21K15425
[Journal Article] Ppp6c haploinsufficiency accelerates UV-induced BRAF(V600E)-initiated melanomagenesis.2021
- Author(s)
  Kanazawa K, Kishimoto K, Nomura M, Kurosawa K, Kato H, Inoue Y, Miura K, Fukui K, Yamashita Y, Sato I, Tsuji H, Watanabe T, Tanaka T, Yasuda J, Tanuma N, Shima H
- Journal Title
  
  Cancer Sci.
  
  Volume: in press Issue: 6 Pages: 2233-2244
- DOI
  10.1111/cas.14895
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09469, KAKENHI-PROJECT-19K18757, KAKENHI-PROJECT-20K17365, KAKENHI-PROJECT-20K06545, KAKENHI-PROJECT-20K07436, KAKENHI-PROJECT-21K15425
[Journal Article] Divergent metabolic responses dictate vulnerability to NAMPT inhibition in ovarian cancer2020
- Author(s)
  Kudo Kei、Nomura Miyuki、Sakamoto Yoshimi、Ito Shigemi、Morita Mami、Kawai Masaaki、Yamashita Yoji、Ito Kiyoshi、Yamada Hidekazu、Shima Hiroshi、Yaegashi Nobuo、Tanuma Nobuhiro
- Journal Title
  
  FEBS Letters
  
  Volume: 594 Issue: 9 Pages: 1379-1388
- DOI
  10.1002/1873-3468.13736
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K09469, KAKENHI-PROJECT-17K07187, KAKENHI-PROJECT-19K09109, KAKENHI-PROJECT-18K09243, KAKENHI-PROJECT-17K07231, KAKENHI-PROJECT-18K15965
[Journal Article] Novel activating KRAS mutation candidates in lung adenocarcinoma2020
- Author(s)
  Abe Jiro、Tanuma Nobuhiro、Nomura Miyuki、Ito Shin、Kasugai Isao、Sato Ikuro、Tamai Keiichi、Mochizuki Mai、Yamaguchi Kazunori、Shima Hiroshi、Okada Yoshinori、Yasuda Jun
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 522 Issue: 3 Pages: 690-696
- DOI
  10.1016/j.bbrc.2019.11.151
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K07187, KAKENHI-PROJECT-17K07193, KAKENHI-PROJECT-17K07231
[Journal Article] Establishment of a Monoclonal Antibody That Recognizes Cysteine-Rich Domain 1 of Human CD2712020
- Author(s)
  Morita Shinkichi、Mochizuki Mai、Shibuya-Takahashi Rie、Nakamura-Shima Mao、Yamazaki Tomoko、Imai Takayuki、Asada Yukinori、Matsuura Kazuto、Kawamura Sadafumi、Yamaguchi Kazunori、Yasuda Jun、Sugamura Kazuo、Katori Yukio、Satoh Kennichi、Tamai Keiichi
- Journal Title
  
  Monoclonal Antibodies in Immunodiagnosis and Immunotherapy
  
  Volume: 39 Issue: 1 Pages: 6-11
- DOI
  10.1089/mab.2019.0040
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K09334, KAKENHI-PROJECT-18K09363, KAKENHI-PROJECT-18K16432, KAKENHI-PROJECT-19K16816, KAKENHI-PROJECT-17K07193, KAKENHI-PROJECT-17K11166, KAKENHI-PROJECT-17K11414, KAKENHI-PROJECT-19K08430, KAKENHI-PROJECT-19K09295, KAKENHI-PROJECT-19K09903
[Journal Article] Loss of protein phosphatase 6 in mouse keratinocytes enhances K-rasG12D-driven tumor promotion.2018
- Author(s)
  Kurosawa K, Inoue Y, Kakugawa Y, Yamashita Y, Kanazawa K, Kishimoto K, Nomura M, Momoi Y, Sato I, Chiba N, Suzuki M, Ogoh H, Yamada H, Miura K, Watanabe T, Tanuma N, Tachi M, and Shima H
- Journal Title
  
  Cancer Science
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K07187
[Journal Article] Loss of protein phosphatase 6 in mouse keratinocytes enhances K-rasG12D-driven tumor promotion.2018
- Author(s)
  Kurosawa K, Inoue Y, Kakugawa Y, Yamashita Y, Kanazawa K, Kishimoto K, Nomura M, Momoi Y, Sato I, Chiba N, Suzuki M, Ogoh H, Yamada H, Miura K, Watanabe T, Tanuma N, Tachi M, and Shima H
- Journal Title
  
  Cancer Science
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K15714
[Journal Article] Loss of protein phosphatase 6 in mouse keratinocytes enhances K-rasG12D-driven tumor promotion.2018
- Author(s)
  Kurosawa K, Inoue Y, Kakugawa Y, Yamashita Y, Kanazawa K, Kishimoto K, Nomura M, Momoi Y, Sato I, Chiba N, Suzuki M, Ogoh H, Yamada H, Miura K, Watanabe T, Tanuma N, Tachi M, and Shima H
- Journal Title
  
  Cancer Science
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10774
[Journal Article] PKM1 Confers Metabolic Advantages and Promotes Cell-Autonomous Tumor Cell Growth.2018
- Author(s)
  M Morita, T Sato, M Nomura, Y Sakamoto, Y Inoue, R Tanaka, S Ito, K Kurosawa, K Yamaguchi, Y Sugiura, H Takizaki, Y Yamashita, R Katakura, I Sato, Y Okada, H Watanabe, G Kondoh, et al.
- Journal Title
  
  Cancer Cell
  
  Volume: 12 Issue: 3 Pages: 355-367
- DOI
  10.1016/j.ccell.2018.02.004
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07296, KAKENHI-PROJECT-16K09597, KAKENHI-PROJECT-16K10486, KAKENHI-PROJECT-17K19620, KAKENHI-PROJECT-17K16876, KAKENHI-PLANNED-25111006, KAKENHI-PROJECT-16H04730, KAKENHI-PROJECT-15K09237, KAKENHI-PROJECT-15K21098, KAKENHI-PROJECT-16K19745, KAKENHI-PROJECT-17K07187, KAKENHI-PUBLICLY-17H05534, KAKENHI-PUBLICLY-17H06011, KAKENHI-PROJECT-16K10774, KAKENHI-PROJECT-17K19606, KAKENHI-PLANNED-17H06301, KAKENHI-PROJECT-16K07187, KAKENHI-PROJECT-17K07231
[Journal Article] Loss of protein phosphatase 6 in mouse keratinocytes enhances K-rasG12D-driven tumor promotion.2018
- Author(s)
  Kurosawa K, Inoue Y, Kakugawa Y, Yamashita Y, Kanazawa K, Kishimoto K, Nomura M, Momoi Y, Sato I, Chiba N, Suzuki M, Ogoh H, Yamada H, Miura K, Watanabe T, Tanuma N, Tachi M, and Shima H
- Journal Title
  
  Cancer Science
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K10081
[Journal Article] Loss of protein phosphatase 6 in mouse keratinocytes enhances K-ras G12D -driven tumor promotion2018
- Author(s)
  Kurosawa Koreyuki、Inoue Yui、Kakugawa Yoichiro、Yamashita Yoji、Kanazawa Kosuke、Kishimoto Kazuhiro、Nomura Miyuki、Momoi Yuki、Sato Ikuro、Chiba Natsuko、Suzuki Mai、Ogoh Honami、Yamada Hidekazu、Miura Koh、Watanabe Toshio、Tanuma Nobuhiro、Tachi Masahiro、Shima Hiroshi
- Journal Title
  
  Cancer Science
  
  Volume: 109 Issue: 7 Pages: 2178-2187
- DOI
  10.1111/cas.13638
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07187, KAKENHI-PROJECT-17K10660, KAKENHI-PROJECT-18K16043, KAKENHI-PROJECT-16H04690, KAKENHI-PROJECT-16K07296, KAKENHI-PROJECT-16K10486, KAKENHI-PROJECT-16K10774, KAKENHI-PROJECT-17K16358, KAKENHI-PROJECT-17K16876, KAKENHI-PROJECT-18K09243, KAKENHI-PROJECT-16K07187, KAKENHI-PROJECT-17K19620
[Journal Article] A-kinase anchoring protein BIG3 coordinates oestrogen signalling in breast cancer cells.2017
- Author(s)
  Yoshimaru T, Ono M, Bando Y, Chen YA, Mizuguchi K, Shima H, Komatsu M, Imoto I, Izumi K, Honda J, Miyoshi Y, Sasa M, Katagiri T
- Journal Title
  
  Nature Communications
  
  Volume: 印刷中 Issue: 1 Pages: 15427-15427
- DOI
  10.1038/ncomms15427
- NAID
  120006535065
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26461948, KAKENHI-PROJECT-17K07187, KAKENHI-PUBLICLY-16H01575, KAKENHI-PROJECT-16H05153
[Journal Article] Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics2017
- Author(s)
  Akaike Takaaki、、、Nishida Motohiro（4）、、、、、、Fujii Shigemoto（20）、、、Motohashi Hozumi（26）
- Journal Title
  
  Nature Communications
  
  Volume: 8 Issue: 1 Pages: 1177-1177
- DOI
  10.1038/s41467-017-01311-y
- NAID
  120007134656
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16KT0013, KAKENHI-PROJECT-16K09398, KAKENHI-PROJECT-17K07187, KAKENHI-PROJECT-17K08619, KAKENHI-PROJECT-17K19205, KAKENHI-PROJECT-17K19508, KAKENHI-PROJECT-17K19620, KAKENHI-PROJECT-17K15408, KAKENHI-PROJECT-17K15464, KAKENHI-PROJECT-17K17583, KAKENHI-INTERNATIONAL-15K21759, KAKENHI-PLANNED-26110003, KAKENHI-ORGANIZER-26111001, KAKENHI-PLANNED-26111008, KAKENHI-PLANNED-26111011, KAKENHI-PROJECT-17H06170, KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-15H03115, KAKENHI-PROJECT-15H04335, KAKENHI-PROJECT-15H04692, KAKENHI-PROJECT-16H04674, KAKENHI-PROJECT-17F17116, KAKENHI-PROJECT-15K08178, KAKENHI-PROJECT-15K08456, KAKENHI-PROJECT-16K13089, KAKENHI-PROJECT-16K15208, KAKENHI-PROJECT-15K20855, KAKENHI-PROJECT-15K20857, KAKENHI-PROJECT-15K20876, KAKENHI-PLANNED-26116005, KAKENHI-PROJECT-16H05092
[Journal Article] Ex vivo model of non-small cell lung cancer using mouse lung epithelial cells.2017
- Author(s)
  Sato T, Morita M, Tanaka R, Inoue Y, Nomura M, Sakamoto Y, Miura K, Ito S, Sato I, Tanaka N, Abe J, Takahashi S, Kawai M, Sato M, Hippo Y, Shima H, Okada Y, Tanuma N
- Journal Title
  
  Oncol Lett.
  
  Volume: 14(6) Pages: 6863-6868
- DOI
  10.3892/ol.2017.7098
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K10486, KAKENHI-PROJECT-17K07187, KAKENHI-PROJECT-17K10660, KAKENHI-PROJECT-17K10796, KAKENHI-PROJECT-17K19620, KAKENHI-PROJECT-17K19624, KAKENHI-PROJECT-17K16876, KAKENHI-PROJECT-16K19745
[Journal Article] Sialidase NEU3 defines invasive potential of human glioblastoma cells by regulating calpain-mediated proteolysis of focal adhesion proteins2017
- Author(s)
  Takahashi Kohta、Proshin Sergei、Yamaguchi Kazunori、Yamashita Yoji、Katakura Ryuichi、Yamamoto Koji、Shima Hiroshi、Hosono Masahiro、Miyagi Taeko
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - General Subjects
  
  Volume: 1861 Issue: 11 Pages: 2778-2788
- DOI
  10.1016/j.bbagen.2017.07.023
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10774, KAKENHI-PROJECT-17K07187
[Journal Article] Drug delivery of oral anti-cancer fluoropyrimidine agents.2017
- Author(s)
  Miura K, Shima H, Takebe N, Julie R, Satoh K, Kakugawa Y, Satoh M, Kinouchi M, Yamamoto K, Hasegawa Y, Kawai M, Kanazawa K, Fujiya T, Unno M and Katakura R.
- Journal Title
  
  Expert Opin.Drug Deliv
  
  Volume: 印刷中 Issue: 12 Pages: 1-12
- DOI
  10.1080/17425247.2017.1316260
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26430130, KAKENHI-PROJECT-26461967, KAKENHI-PROJECT-17K07187, KAKENHI-PROJECT-17K10660, KAKENHI-PROJECT-15K10081
[Journal Article] Enhanced expression of PKM2 is involved in the gastric cancer development via regulating cancer specific metabolism.2017
- Author(s)
  Shiroki T, Yokoyama M, Tanuma N, Maejima R, Tamai K, Yamaguchi K, Oikawa T, Noguchi T, Miura K, Fujiya T, Shima H, Sato I, Kamiya N, Hatakeyama M, Iijima K, Shimosegawa T and Satoh K.
- Journal Title
  
  Cancer Science
  
  Volume: 印刷中 Issue: 5 Pages: 931-940
- DOI
  10.1111/cas.13211
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26430130, KAKENHI-PROJECT-26461967, KAKENHI-PROJECT-26462077, KAKENHI-PROJECT-15K19080, KAKENHI-PROJECT-16K08773, KAKENHI-PROJECT-17K07187, KAKENHI-PROJECT-17K10660, KAKENHI-PROJECT-17K19620, KAKENHI-PROJECT-16H06373, KAKENHI-PROJECT-16K15273, KAKENHI-PROJECT-16K07132
[Journal Article] A-kinase anchoring protein BIG3 coordinates oestrogen signaling in breast cancer cells.2017
- Author(s)
  Yoshimaru T, Ono M, Bando Y, Yi-An Chen, Mizuguchi K, Shima H, Komatsu M, Imoto I, Izumi K, Honda J, Miyoshi Y, Sasa M and Katagiri T.
- Journal Title
  
  Nat. Commun.
  
  Volume: 印刷中
- NAID
  120006535065
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26430130
[Journal Article] Nuclear pyruvate kinase M2 complex serves as a transcriptional coactivator of arylhydrocarbon receptor.2016
- Author(s)
  Matsuda S, Adachi J, Ihara M, Tanuma N, Shima H, Kakizuka A, Ikura M, Ikura T, Matsuda T
- Journal Title
  
  Nucleic Acids Res.
  
  Volume: 44（2） Pages: 636-647
- NAID
  120005818255
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26430130
[Journal Article] SERPINI1 regulates epithelial– mesenchymal transition in an orthotopic implantation model of colorectal cancer.2016
- Author(s)
  Yasufumi Matsuda, Koh Miura, Junko Yamane, Hiroshi Shima, Wataru Fujibuchi, Kazuyuki Ishida, Fumiyoshi Fujishima, Shinobu Ohnuma, Hiroyuki Sasaki, Munenori Nagao, Naoki Tanaka, Kennichi Satoh, Takeshi Naitoh, Michiaki Unno
- Journal Title
  
  Cancer Science
  
  Volume: - Issue: 5 Pages: 619-628
- DOI
  10.1111/cas.12909
- NAID
  120005767016
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26430130, KAKENHI-PROJECT-26461967
[Journal Article] The protein phosphatase 6 catalytic subunit (Ppp6c) is indispensable for proper post-implantation embryogenesis.2016
- Author(s)
  Ogoh, H., Tanuma, N., Matsui, Y., Hayakawa, N., Inagaki, A., Sumiyoshi, M., Momoi, Y., Kishimoto, A., Suzuki, M., Sasaki, N., Ohuchi, T., Nomura, M., Teruya, Y., Yasuda, K., Watanabe, T., Shima, H.
- Journal Title
  
  Mechanisms of Development
  
  Volume: 139 Pages: 1-9
- DOI
  10.1016/j.mod.2016.02.001
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-25114003, KAKENHI-PROJECT-25650104, KAKENHI-PROJECT-26430130, KAKENHI-PROJECT-16K14621, KAKENHI-PROJECT-15K20237
[Journal Article] Pyruvate kinase M2, but not M1, allele maintains immature metabolic states of murine embryonic stem cells2015
- Author(s)
  Konno, M., Ishii, H., Koseki, J., Tanuma, N., Nishida, N., Kawamoto, K., Nishimura, T., Nakata, A., Matsui, H., Noguchi, K., Ozaki, M., Noguchi, Y., Shima, H., Gotoh N., Nagano, H., Doki, Y. and Mori, M.
- Journal Title
  
  Regenerative Therapy
  
  Volume: 1 Pages: 63-71
- DOI
  10.1016/j.reth.2015.01.001
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-25134713, KAKENHI-PROJECT-25730017, KAKENHI-PROJECT-26430130, KAKENHI-PROJECT-15K15474, KAKENHI-PROJECT-15K15496, KAKENHI-PROJECT-15H04294, KAKENHI-PROJECT-15H05664, KAKENHI-PROJECT-26640072, KAKENHI-PROJECT-26293303, KAKENHI-PROJECT-15H05791
[Journal Article] Potentiation of Epidermal Growth Factor-Mediated Oncogenic Transformation by Sialidase NEU3 Leading to Src Activation.2015
- Author(s)
  Yamamoto K, Takahashi K, Shiozaki K, Yamaguchi K, Moriya S, Hosono M, Shima H, Miyagi T.
- Journal Title
  
  PLoS One
  
  Volume: 10 Issue: 3 Pages: e0120578-e0120578
- DOI
  10.1371/journal.pone.0120578
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25290047, KAKENHI-PROJECT-26430130
[Journal Article] Abrogation of protein phosphatase 6 promotes skin carcinogenesis induced by DMBA2015
- Author(s)
  Hayashi K, Momoi Y , Tanuma N, Kishimoto A, Ogoh H, Kato H, Suzuki M, Sakamoto Y, Inoue Y, Nomura M, Kiyonari H, Sakayori M, Fukamachi K, Kakugawa Y, Yamashita Y, Ito S, Sato I, Suzuki A, Nishio M, Suganuma M, Watanabe T, and Shima H
- Journal Title
  
  Oncogene
  
  Volume: 印刷中 Issue: 35 Pages: 4647-55
- DOI
  10.1038/onc.2014.398
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24570159, KAKENHI-PROJECT-24591928, KAKENHI-PROJECT-25861168, KAKENHI-PROJECT-15K10081, KAKENHI-PROJECT-26430130, KAKENHI-PROJECT-15K19081, KAKENHI-PROJECT-15K20237, KAKENHI-PROJECT-25430163
[Journal Article] Mice doubly-deficient in the Arf GAPs SMAP1 and SMAP2 exhibit embryonic lethality2015
- Author(s)
  Sumiyoshi M, Rai S, Tanaka H, Matsumura I, et al.
- Journal Title
  
  FEBS Lett.
  
  Volume: 589 Issue: 19PartB Pages: 2754-2762
- DOI
  10.1016/j.febslet.2015.07.050
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09461, KAKENHI-PROJECT-26430130, KAKENHI-PLANNED-25114003, KAKENHI-PROJECT-25461439, KAKENHI-PROJECT-25650104
[Journal Article] Nuclear pyruvate kinase M2 complex serves as a transcriptional coactivator of arylhydrocarbon receptor.2015
- Author(s)
  Shun Matsuda, Jun Adachi, Masaru Ihara, Nobuhiro Tanuma, Hiroshi Shima, Akira Kakizuka, Masae Ikura, Tsuyoshi Ikura, Tomonari Matsuda
- Journal Title
  
  Nucleic Acids Res
  
  Volume: 44(2) Issue: 2 Pages: 636-647
- DOI
  10.1093/nar/gkv967
- NAID
  120005818255
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26430130, KAKENHI-PROJECT-15K12203, KAKENHI-PUBLICLY-15H01181, KAKENHI-PROJECT-23221006, KAKENHI-PROJECT-26550028, KAKENHI-PROJECT-26281020
[Journal Article] Embryonic microRNA-369 controls metabolic splicing factors and urges cellular reprograming.2015
- Author(s)
  Masamitsu Konno, Jun Koseki, Koichi Kawamoto, Naohiro Nishida, Hidetoshi Matsui, Dyah Laksmi Dewi, Miyuki Ozaki, Yuko Noguchi, Koshi Mimori, Noriko Gotoh, Nobuhiro Tanuma, Hiroshi Shima, Yuichiro Doki, Masaki Mori , Hideshi Ishii
- Journal Title
  
  PLOS ONE
  
  Volume: 10(7) Issue: 7 Pages: 1-16
- DOI
  10.1371/journal.pone.0132789
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26430130, KAKENHI-PROJECT-15K15474, KAKENHI-PROJECT-15K15496, KAKENHI-PROJECT-15H04294, KAKENHI-PROJECT-15H05664, KAKENHI-PROJECT-26640072, KAKENHI-PROJECT-26670604, KAKENHI-PROJECT-26293303, KAKENHI-PROJECT-15H05791
[Journal Article] Sialidase NEU3 contributes neoplastic potential on colon cancer cells as a key modulator of gangliosides by regulating Wnt signaling.2015
- Author(s)
  Takahashi K, Hosono M, Sato I, Hata K, Wada T, Yamaguchi K, Nitta K, Shima H, Miyagi T.
- Journal Title
  
  Int J Cancer
  
  Volume: published online Issue: 7 Pages: 00-00
- DOI
  10.1002/ijc.29527
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24570142, KAKENHI-PROJECT-26430130, KAKENHI-PROJECT-25430163
[Journal Article] Loss of protein phosphatase 6 in mouse keratinocytes increases susceptibility to ultraviolet-B-induced carcinogenesis.2015
- Author(s)
  Kato H, Kurosawa K, Inoue Y, Tanuma N, Momoi Y, Hayashi K, Ogoh H, Nomura M, Sakayori M, Kakugawa Y, Yamashita Y, Miura K, Maemondo M, Katakura R, Ito S, Sato M, Sato I, Chiba N, Watanabe T, Shima H.
- Journal Title
  
  Cancer Lett.
  
  Volume: 365 Issue: 2 Pages: 223-228
- DOI
  10.1016/j.canlet.2015.05.022
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K09237, KAKENHI-PROJECT-15K10081, KAKENHI-PROJECT-26430130, KAKENHI-PROJECT-26461967, KAKENHI-PROJECT-15K14387, KAKENHI-PROJECT-15K19081, KAKENHI-PROJECT-15K20237, KAKENHI-PROJECT-25430163, KAKENHI-PROJECT-25670609
[Journal Article] Loss of NDRG2 expression activates PI3K-AKT signalling via PTEN phosphorylation in ATLL and other cancers.2014
- Author(s)
  Nakahata S, Ichikawa T, Maneesaay P, Saito Y, Nagai K, Tamura T, Manachai N, Yamakawa N, Hamasaki M, Kitabayashi I, Arai Y, Kanai Y, Taki T, Abe T, Kiyonari H, Shimoda K, Ohshima K, Horii A, Shima H, Taniwaki M, Yamaguchi R, Morishita K.
- Journal Title
  
  Nat Commun
  
  Volume: in press Issue: 1 Pages: 3393-3393
- DOI
  10.1038/ncomms4393
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23590452, KAKENHI-PROJECT-24591407, KAKENHI-PROJECT-24591928, KAKENHI-PUBLICLY-25118720, KAKENHI-PROJECT-25293081, KAKENHI-PROJECT-25430113, KAKENHI-PROJECT-25860242, KAKENHI-PROJECT-26430130
[Journal Article] Loss of NDRG2 expression activates PI3K-AKTsignalling via PTEN phosphorylation in ATLL and other cancers2014
- Author(s)
  Shingo Nakahata　他17名、Hiroshi Shima， Masafumi Taniwaki， Ryoji Yamaguche， and Kazuhiro Morishita
- Journal Title
  
  Nature Communications.
  
  Volume: 5 Pages: 3393-3393
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659621
[Journal Article] Loss of NDRG2 expression activates PI3K-AKTsignalling via PTEN phosphorylation in ATLL and other cancers2014
- Author(s)
  Shingo Nakahata　他17名、Hiroshi Shima， Masafumi Taniwaki， Ryoji Yamaguche， and Kazuhiro Morishita
- Journal Title
  
  Nature Communications
  
  Volume: 5 Pages: 3393-3393
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592149
[Journal Article] Loss of NDRG2 expression activates PI3K-AKTsignalling via PTEN phosphorylation in ATLL and other cancers2014
- Author(s)
  Shingo Nakahata他17名、Hiroshi Shima,Masafumi Taniwaki,RyojiY amaguche,and Kazuhiro Morishita
- Journal Title
  
  Nature Communications
  
  Volume: 5巻 Pages: 3393-3393
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659621
[Journal Article] p190A RhoGAP is involved in EGFR pathways and promotes proliferation, invasion and migration in lung adenocarcinoma cells2013
- Author(s)
  Notsuda H, Sakurada A, Endo C, Okada Y, Horii A, Shima H, Kondo T
- Journal Title
  
  Int J Oncol
  
  Volume: 43巻 Pages: 1569-77
- Data Source
  KAKENHI-PROJECT-24659621
[Journal Article] p190A RhoGAP is involved in EGFR pathways and promotes proliferation, invasion and migration in lung adenocarcinoma cells.2013
- Author(s)
  Notsuda H, Sakurada A, Endo C, Okada Y, Horii A, Shima H, Kondo T.
- Journal Title
  
  Int J Oncol
  
  Volume: 43 Issue: 5 Pages: 1569-1577
- DOI
  10.3892/ijo.2013.2096
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590452, KAKENHI-PROJECT-24591928, KAKENHI-PROJECT-24659624, KAKENHI-PROJECT-25462170
[Journal Article] 経胸腹経路による広範切除を行い胸腹壁再建を行った悪性線維性組織球腫2012
- Author(s)
  大塚綱志、原田亜矢、脇田和博、青木雅也、永田俊行、狩集弘太、酒瀬川浩一、中村好宏、佐藤雅美、中山博史、北島信一
- Journal Title
  
  胸部外科
  
  Volume: 65 Pages: 389-392
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390272
[Journal Article] Novel function of MKP-5/DUSP10, a phosphatase of stress-activated kinases, on ERK-dependent gene expression, and upregulation of its gene expression in colon carcinomas2012
- Author(s)
  Nomura M, Shiiba K, Katagiri C, Kasugai I, Masuda K, Sato I, Sato M, Kakugawa Y, Nomura E, Hayashi K, Nakamura Y, Nagata T, Otsuka T, Katakura R, Yamashita Y, Sato M, Tanuma N, Shima H
- Journal Title
  
  Oncol Rep
  
  Volume: 28(3) Pages: 931-6
- DOI
  10.3892/or.2012.1862
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390272
[Journal Article] Novel function of MKP-5/DUSP10, a phosphatase for stress-activated kinases, on ERK dependent gene expression, and up-regulation of its gene expression in colon carcinomas2012
- Author(s)
  Nomura M、Yamashita Y、Shima H
- Journal Title
  
  Oncol Rep
  
  Volume: 28巻 Pages: 931-936
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592149
[Journal Article] 脱リン酸化側からの、がん（脳腫瘍）診断•治療へのアプローチ2012
- Author(s)
  島　礼
- Journal Title
  
  臨床病理
  
  Volume: 60 Pages: 1145-1147
- NAID
  10031147847
- Data Source
  KAKENHI-PROJECT-22590298
[Journal Article] Sialidase NEU4 Hydrolyzes PolysialicAcids of Neural Cell Adhesion Molecules and Negatively Regulates Neurite Formation by Hippocampal Neurons J.Biol.Chem.2012
- Author(s)
  Takahashi K, Mitoma J, Hosono M, Shiozaki K, Sato C, Yamaguchi K, Kitajima K, Higashi H, Nitta K, Shima H, and Miyagi T
- Journal Title
  
  J.Biol.Chem.
  
  Volume: 287(18) Pages: 14816-26
- Data Source
  KAKENHI-PROJECT-22590298
[Journal Article] Sialidase NEU4 Hydrolyzes Polysialic Acids of Neural Cell Adhesion Molecules and Negatively Regulates Neurite Formation by Hippocampal Neurons2012
- Author(s)
  Takahashi K、Shima H
- Journal Title
  
  J Biol Chem
  
  Volume: 287巻 Pages: 14816-14826
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592149
[Journal Article] Sialidase NEU4 Hydrolyzes Polysialic Acids of Neural Cell Adhesion Molecules and Negatively Regulates Neurite Formation by Hippocampal Neurons2012
- Author(s)
  Hiroshi Shima
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 未定
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592149
[Journal Article] Novel function of MKP-5/DUSP10, a phosphatase for stress-activated kinases, on ERK dependent gene expression,and up-regulation of its gene expression in colon carcinomas2012
- Author(s)
  Nomura M, Shiiba K-I, Katagiri C, Kasugai I, Masuda K, Sato I, Sato M, Kakugawa Y, Nomura E, Hayashi K, Nakamura Y, Nagata T, Otsuka T, KatakuraR, Yamashita Y, Sato M, Tanuma N, Shima H
- Journal Title
  
  Oncol Rep.
  
  Volume: 28(3) Pages: 931-6
- Data Source
  KAKENHI-PROJECT-22590298
[Journal Article] Cytological Characteristics of Pulmonary Pleomorphic and Giant Cell Carcinomas.2011
- Author(s)
  Hiroshima K, Akita H, Usuda K, Ogura S, Kusunoki Y, Kodama T, Saito Y, Sato M, Tagawa Y, Baba M, Hirano T, Horai T, MatsunoY
- Journal Title
  
  Acta Cytologica
  
  Volume: 55 Issue: 2 Pages: 173-179
- DOI
  10.1159/000320860
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390272
[Journal Article] DUSP13B/TMDP inhibits stress-activated MAPKs and suppresses AP-1-dependent gene expression2011
- Author(s)
  Katagiri C, Masuda K, Nomura M, Tanoue K, Fujita S, Yamashita Y, Katakura R, Shiiba K, Nomura E, Sato M, Tanuma N, Shima H
- Journal Title
  
  Mol Cell Biochem
  
  Volume: 352(1-2) Issue: 1-2 Pages: 155-62
- DOI
  10.1007/s11010-011-0749-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390272, KAKENHI-PROJECT-23650629, KAKENHI-PROJECT-23659700
[Journal Article] DUSP13B/TMDPinhibits stress-activated MAPKs and suppresses AP-1-dependent gene expression2011
- Author(s)
  Katagiri C, Masuda K, Nomura M, Tanoue K, Fujita S, Yamashita Y, Katakura R, Shiiba K, Nomura E, Sato M, Tanuma N, Shima H
- Journal Title
  
  Molecular and Cellular Biochemistry
  
  Volume: 352(1-2) Pages: 155-162
- Data Source
  KAKENHI-PROJECT-22590298
[Journal Article] MKP-7, a JNK phosphatase, blocks ERK-dependent gene activation by anchoring phosphorylated ERK in the cytoplasm.2010
- Author(s)
  Masuda K, Katagiri C, Nomura M, Sato M, Kakumoto K, Akagi T, Kikuchi K, Tanuma N, Shima H.
- Journal Title
  
  Biochem Biophys Res Commun 393
  
  Pages: 201-206
- Data Source
  KAKENHI-PROJECT-19390370
[Journal Article] CDC25A mRNA levels significantly correlate with Ki-67 expression in human glioma samples.2010
- Author(s)
  Yamashita Y, Kasugai I, Sato M, Tanuma N, Sato I, Nomura M, Yamashita K, Sonoda Y, Kumabe T, Tominaga T, Katakura R, Shima H
- Journal Title
  
  J Neurooncol 100
  
  Pages: 43-49
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591730
[Journal Article] CDC25A mRNA levels significantly c orrelate with Ki-67 expression in human glioma samples2010
- Author(s)
  Yamashita Y, Kasugai I, Sato M, Tanuma N, Sato I, Nomura M, Yamashita K,Sonoda Y, Kumabe T, Tominaga T, Katakura R, Shima H
- Journal Title
  
  Journal of Neuro-Oncology
  
  Volume: 100(1) Pages: 43-49
- Data Source
  KAKENHI-PROJECT-22590298
[Journal Article] The phosphatase interactor NIPP1 regulates the occupancy of the histone methyltransferase EZH2 at Polycomb targets.2010
- Author(s)
  Van Dessel N, Beke L, Gornemann J, Minnebo N, Beullens M, Tanuma N, Shima H, Van Eynde A, Bollen M.
- Journal Title
  
  Nucleic Acids Res.
  
  Volume: 38(21) Pages: 7500-7512
- Data Source
  KAKENHI-PROJECT-22590298
[Journal Article] MKP-7, a JNK phosphatase, blocks ERK-dependent gene activation by anchoring phosphorylated ERK in the cytoplasm2010
- Author(s)
  Masuda K, Katagiri C, Nomura M, Sato M, Kakumoto K, Akagi T, Kikuchi K, Tanuma N, Shima H
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 393(2) Issue: 2 Pages: 201-6
- DOI
  10.1016/j.bbrc.2010.01.097
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390272
[Journal Article] CDC25A mRNA levels significantly correlate with Ki-67 expression in human glioma samples2010
- Author(s)
  Yamashita Y, Kasugai I, Sato M, Tanuma N, Sato I, Nomura M, Yamashita K, Sonoda Y, Kumabe T, Tominaga T, Katakura R, Shima H
- Journal Title
  
  J Neuroncol
  
  Volume: 100 Issue: 1 Pages: 43-4
- DOI
  10.1007/s11060-010-0147-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390272
[Journal Article] MKP-7, a JNK phosphatase, blocks ERK-dependent gene activation by anchoring phosphorylated ERK in the cytoplasm2010
- Author(s)
  Masuda K, Katagiri C, Nomura M, SatoM, Kakumoto K, Akagi T, KikuchiK, Tanuma N, Shima H
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 393 Pages: 201-206
- Data Source
  KAKENHI-PROJECT-22590298
[Journal Article] Protein phosphatase Dusp26 associates with KIF3 motor and promotes N-cadherin-mediaded cell-cel adhesion.2009
- Author(s)
  Tanuma N, Nomura M, Ikdea M, Kusugai I, Tsubaki Y, Takagaki K, Kawamura T, Yamashita Y, Sato I, Sato M, Katakura R, Kikuchi K, Shima H
- Journal Title
  
  Oncogene 28
  
  Pages: 752-76
- Data Source
  KAKENHI-PROJECT-19390370
[Journal Article] Protein phosphatase Dusp26 associates with KIF3 motor and promotes N-cadherin-mediated cell-cell adhesion.2009
- Author(s)
  Tanuma N, Nomura M, Ikeda M, Kasugai I, Tsubaki Y, Takagaki K, Kawamura T, Yamashita Y, Sato I, Sato M, Katakura R, Kikuchi K, Shima H
- Journal Title
  
  Oncogene 28
  
  Pages: 752-761
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591730
[Journal Article] Protein phosphatase Dusp26 associates with KIF3 motor and promotes N-cadherin-mediated cell-cell adhesion.2009
- Author(s)
  Tanuma N, Nomura M, Ikeda M, Kasugai I, Tsubaki Y, Takagaki K,Kawamura T, Yamashita Y, Sato I, Sato M, Katakura R, Kikuchi K, Shima H.
- Journal Title
  
  Oncogene 28
  
  Pages: 752-761
- Data Source
  KAKENHI-PROJECT-19570142
[Journal Article] Nuclear inhibitor of protein phosphatase-1 (NIPP1) directs protein phosphatase-1 (PP1) to dephosphorylatethe U2 snRNP component, spliceosome-associated protein 155 (Sap155)2008
- Author(s)
  Tanuma N, Kim S-E, Beullens M, Tsubaki Y, Mitsuhashi S, Nomura M, Kawamura T, Isono K, Koseki H, Sato M, Bollen M, Kikuchi K, Shima H.
- Journal Title
  
  Journal of Biological Chemistry 283(51)
  
  Pages: 35805-35814
- Data Source
  KAKENHI-PROJECT-19570142
[Journal Article] Pyrogallol structure in polyphenol is involved in apoptosis-induction on HEK293T and K562 cells.2008
- Author(s)
  Mitsuhashi S, Saito A, Nakajima N, Shima H, Ubukata M
- Journal Title
  
  Molecules 13(12)
  
  Pages: 2998-3006
- Data Source
  KAKENHI-PROJECT-19570142
[Journal Article] Tautomycetin suppresses the TNFa/NFkB pathway via inhibition of IKK activation2008
- Author(s)
  Mitsuhashi S, Shima H, Li Y, Tanuma N, Okamoto T, Kikuchi K, Ubukata M.
- Journal Title
  
  International Journal of Oncology 33(5)
  
  Pages: 1027-1035
- Data Source
  KAKENHI-PROJECT-19570142
[Journal Article] Nuclear inhibitor of protein phosphatase-1 (NIPP1) directs protein phosphatase-1(PP1) to dephosphorylate the U2 small nuclesr ribonucleoprotein particle(snRNP)component2008
- Author(s)
  Tanuma N, Kim SE, Buellens M, Tsubaki Y, Mitsuhashi S, Nomura M, Kawamura T, Isono K, Koseki H, Sato M, Bollen M, Kikuchi K, Shima H
- Journal Title
  
  spliceosome-associated protein 155 (Sap155). J Biol Chem 52
  
  Pages: 35805-35814
- Data Source
  KAKENHI-PROJECT-19390370
[Journal Article] Characterization of a novel low-molecular-mass dual specificity phosphatase-4 (LDP-4) expressed in brain.2007
- Author(s)
  Takagaki K, Shima H, Tanuma N, Nomura M, Satoh T, Watanabe M, Kikuchi K.
- Journal Title
  
  Molecular and Cellular Biochemistry 296(1-2)
  
  Pages: 177-84
- Data Source
  KAKENHI-PROJECT-19570142
[Journal Article] Vimentin-Ser82 as a memory phosphorylation site in astrocytes.2006
- Author(s)
  Oguri T, Inoko A, Shima H, Izawa I, Arimura N, Yamaguchi T, Inagaki N, Kaibuchi K, Kikuchi K, Inagaki M.
- Journal Title
  
  Genes Cells 11
  
  Pages: 531-540
- NAID
  120000961744
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16370055
[Journal Article] Manzamenones inhibit T-Cell Protein Tyrosine Phosphatase2006
- Author(s)
  Wakuda Y, Kubota T, Shima H, Okada T, Mitsuhashi S, Aoki N, Kikuchi K, Kobayashi J.
- Journal Title
  
  Mar.Drugs 4
  
  Pages: 9-14
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16370055
[Journal Article] Characterization of a novel low-molecular- mass dual specificity phosphatase-4(LDP-4) expressed in brain2006
- Author(s)
  Takagaki K, Shima H, Tanuma N, Nomura M, Satoh T, Watanabe M, Kikuchi K.
- Journal Title
  
  Mol Cell Biochem 296
  
  Pages: 177-184
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16370055
[Journal Article] Phospho-regulation of human protein kinase Aurora-A : analysis using anti-phopho-Thr288 monoclonal antibodies.2005
- Author(s)
  Ohashi S, Sakashita G, Ban R, Nagasawa M, Matsuzaki H, Murata Y, Taniguchi H, Shima H, Furukawa K, Urano T.
- Journal Title
  
  Oncogene 25
  
  Pages: 7691-7702
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16370055
[Journal Article] pp32/I-1^<PP2A> negatively regulates the Raf/MEK/ERK pathway.2005
- Author(s)
  Fukukawa C, Tanuma N, Okada T, Kikuchi K, Shima H.
- Journal Title
  
  Cancer Lett 226
  
  Pages: 155-160
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16370055
[Journal Article] Phosphorylation of Ser-446 determines stability of MKP-7.2005
- Author(s)
  Katagiri C, Masuda K, Urano T, Yamashita K, Kikuchi K, Shima H.
- Journal Title
  
  J Biol Chem 280
  
  Pages: 14716-14722
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16370055
[Journal Article] Protein phosphatase type 2A, PP2A, is involved in degradation of gp130.2004
- Author(s)
  Mitsuhashi S, Shima H, Tanuma N, Sasa S, Onoe K, Ubukata M, Kikuchi K.
- Journal Title
  
  Mol Cell Biochem 269
  
  Pages: 183-187
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16370055
[Journal Article] Analysis of isoform specific function of PP1 catalytic subunits in mammalian cells using siRNA.2004
- Author(s)
  Okada T, Fujii T, Tanuma N, Mitsuhashi S, Urano T, Araki Y, Shima H, Kikuchi K.
- Journal Title
  
  Int J Oncol 25
  
  Pages: 1383-1388
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16370055
[Journal Article] Nagelamides A-H, new dimeric bromopyrrole alkaloids from marine sponge agelas species.2004
- Author(s)
  Endo T, Tsuda M, Okada T, Mitsuhashi S, Shima H, Kikuchi K, Mikami Y, Fromont J, Kobayashi J.
- Journal Title
  
  J Nat Prod 68
  
  Pages: 1262-1267
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16370055
[Journal Article] Characterization of a novel low-molecular-mass dual-specificity phosphaase 3(LDP-3) that enhances activation of JNK and p38.2004
- Author(s)
  Takagaki K, Satoh T, Tanuma N, Masuda K, Takekawa M, Shima H, Kikuchi K.
- Journal Title
  
  Biochem J 383
  
  Pages: 447-455
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16370055
[Journal Article] The oncoprotein I-2^<PP2A>/SET negatively regulates the MEK/ERK pathway and cell proliferation.2004
- Author(s)
  Fukukawa C, Shima H, Tanuma N, Okada T, Kato N, Adachi Y, Kikuchi K.
- Journal Title
  
  Int J Oncol 26
  
  Pages: 751-756
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16370055
[Presentation] 13Cグルコースを使ったマウス個体でのin vivoトレーサー解析2018
- Author(s)
  田沼延公,、野村美有樹、福原達郎、坂本良美、島礼、本橋ほづみ、紙健次郎
- Organizer
  生化学会東北支部会
- Data Source
  KAKENHI-PROJECT-17K07187
[Presentation] Tissue Specific Deletion of Protein Phosphatase 6 Catalytic Subunit (Ppp6c) Caused Embryonic lethality and postnatal death.2018
- Author(s)
  Watanabe Toshio, Kato Rika, Ogoh Honami, Kishimoto Ayako, Suzuki Mai, Tanuma Nobuhiro, and Shima Hiroshi
- Organizer
  ICPP13, Workshop on Frontiers in Phosphatase Research and Drug Discovery
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07187
[Presentation] 活性型Ｐｋｍ1－Ｐｋｍ２ヘテロ複合体の形成2018
- Author(s)
  野村美有樹、盛田麻美、坂本良美、島礼、田沼延公
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K07187
[Presentation] Loss of protein phosphatase 6 in mouse keratinocytes enhances K-rasG12D-driven tumor promotion.2018
- Author(s)
  Kosuke Kanazawa, Kazuhiro Kishimoto, Yui Inoue, Koh Miura, Nobuhiro Tanuma, and Hiroshi Shima
- Organizer
  Mechanisms & Models of Cancer
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07187
[Presentation] プロテインホスファターゼPP6の機能不全は、ケラチノサイトにおいて、変異型K-rasで誘導される腫瘍化を著しく亢進させる2018
- Author(s)
  岸本和大、金澤孝祐、井上維、田沼延公、島礼
- Organizer
  生化学会東北支部会
- Data Source
  KAKENHI-PROJECT-17K07187
[Presentation] Tie2-Cre Induced Tissue Specific Deletion of Ppp6c Caused Abnormal Hematopoiesis during Mouse Embryogenesis.2018
- Author(s)
  Kato Rika, Ogoh Honami, Kishimoto Ayako, Suzuki Mai, Tanuma Nobuhiro, Shima Hiroshi and Watanabe Toshio
- Organizer
  ICPP13, Workshop on Frontiers in Phosphatase Research and Drug Discovery
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07187
[Presentation] Tumor suppressor activity of protein phosphatase 6.2018
- Author(s)
  Kurosawa Koreyuki, Kakugawa Yoichiro , Tanuma Nobuhiro , Watanabe Toshio, and Shima Hiroshi
- Organizer
  ICPP13, Workshop on Frontiers in Phosphatase Research and Drug Discovery
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07187
[Presentation] [3PT04-01（3P-0454）] オートファジーによるtype 2A protein phosphataseの制御機構の解明2017
- Author(s)
  藤原信行、渋谷周作、坂井祐介、島礼、渡邊利雄、大島浩子、大島正伸、齋藤達哉、審良静男、永野浩昭、臼井達哉、大浜剛、佐藤晃一
- Organizer
  第40回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K07187
[Presentation] 肺神経内分泌腫瘍（NET）における治療標的候補としてのPkm12017
- Author(s)
  盛田麻美、野村美有樹、坂本良美、佐藤卓、田中遼太、福原達朗、佐藤郁郎、中山敬一、前門戸任、島礼、田沼延公
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K07187
[Presentation] Pkm1 とPkm2 の機能解析-非小細胞肺がん（NSCLC）での検討2017
- Author(s)
  野村美有樹、佐藤卓、盛田麻美、坂本良美、田中遼太、三浦康、河合賢朗、佐藤郁郎、島礼、田沼延公
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K07187
[Presentation] Ppp6c は、マウス皮膚のがん抑制遺伝子として働く2017
- Author(s)
  黒沢是之、野村美有樹、角川陽一郎、山下洋二、三浦康、山田秀和、松浦一登、佐藤郁郎、田沼延公、渡邊利雄、島礼
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16K10774
[Presentation] [1AT26-15（1P-0063）] 形質膜シアリダーゼNEU3によるEGFRシグナリングの調節機構2017
- Author(s)
  山本晃司、高橋耕太、塩崎一弘、山口壹範、島礼、宮城妙子
- Organizer
  第40回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K07187
[Presentation] Ppp6c は、マウス皮膚のがん抑制遺伝子として働く2017
- Author(s)
  黒沢是之、野村美有樹、角川陽一郎、山下洋二、三浦康、山田秀和、松浦一登、佐藤郁郎、田沼延公、渡邊利雄、島礼
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-15K10081
[Presentation] Ppp6c は、マウス皮膚のがん抑制遺伝子として働く2017
- Author(s)
  黒沢是之、野村美有樹、角川陽一郎、山下洋二、三浦康、山田秀和、松浦一登、佐藤郁郎、田沼延公、渡邊利雄、島礼
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K07187
[Presentation] Pyruvate kinase Mの両isoformを欠損するマウスの解析2016
- Author(s)
  田中遼太、小河穂波、井上維、山下洋二、三浦康、河合賢郎、佐藤郁郎、渡邊利雄、島礼、田沼延公
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  宮城県・仙台市
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-16K10774
[Presentation] 新規皮膚がん抑制遺伝子Ppp6c変異は、変異型K-RASによる腫瘍発生を強く促進する2016
- Author(s)
  黒沢是之、田沼延公、角川陽一郎、山下洋二、三浦康、山田秀和、佐藤郁郎、野村美有樹、渡利雄、島礼
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  神奈川県・横浜市
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-16K10774
[Presentation] 発がんプロモーターオカダ酸の標的、PP6の皮膚がん抑制遺伝子としての意義2016
- Author(s)
  島礼、黒沢是之、小河穂波、桃井勇貴、井上維、田沼延公、渡邊利雄
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  宮城県・仙台市
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-26430130
[Presentation] 小細胞肺がんにおけるPkm1の役割2016
- Author(s)
  盛田麻美、野村美有樹、坂本良美、佐藤郁郎、島礼、前門戸任、田沼延公
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  神奈川県・横浜市
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-26430130
[Presentation] PKMノックアウトマウスは胎生致死となる2016
- Author(s)
  田中遼太、渡邊利雄、山下洋二、三浦康、佐藤郁郎、島礼、田沼延公
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  神奈川県・横浜市
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-26430130
[Presentation] 小細胞肺がんの代謝特性と、その標的化戦略2016
- Author(s)
  野村美有樹、盛田麻美、坂本良美、伊藤しげみ、佐藤郁郎、島礼、前門戸任、田沼延公
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  神奈川県・横浜市
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-26430130
[Presentation] 遺伝子改変肺上皮細胞を用いた形質転換実験による、代謝酵素Pkmの機能解析2016
- Author(s)
  佐藤卓、坂本良美、野村美有樹、井上維、盛田麻美、田中遼太、渡邊利雄、佐藤郁郎、島礼、岡田克典、田沼延公
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  宮城県・仙台市
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-26430130
[Presentation] Ppp6c deficiency predisposes mouse skin tissue to carcinogenesis initiated by DMBA andUV.2016
- Author(s)
  Hiroshi Shima, Koreyuki Kurosawa, Honami Ogoh, Yui Inoue, Takahiro Goto, Nobuhiro Tanuma, Toshio Watanabe
- Organizer
  The 13th Korea-Japan Joint Symposium on Cancer and Ageing Research
- Place of Presentation
  Jeju (Korea)
- Year and Date
  2016-02-25
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26430130
[Presentation] PKMノックアウトマウスは胎生致死となる2016
- Author(s)
  田中遼太、渡邊利雄、山下洋二、三浦康、佐藤郁郎、島礼、田沼延公
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  神奈川県・横浜市
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-16K10774
[Presentation] 新規皮膚がん抑制遺伝子Ppp6c変異は、変異型K-RASによる腫瘍発生を強く促進する2016
- Author(s)
  黒沢是之、田沼延公、角川陽一郎、山下洋二、三浦康、山田秀和、佐藤郁郎、野村美有樹、渡利雄、島礼
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  神奈川県・横浜市
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-26430130
[Presentation] Functional analysis of the pyruvate kinase M(Pkm) isoforms by transformation experiments of mouse lungs epithelia cells2016
- Author(s)
  佐藤卓、坂本良美、野村美有樹、井上維、盛田麻美、田中遼太、渡邊利雄、佐藤郁郎、島礼、岡田克典、田沼延公
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  神奈川県・横浜市
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-26430130
[Presentation] 形質膜シアリダーゼNEU3によるEGFRシグナリングの活性化機構2016
- Author(s)
  山本晃司、高橋耕太、塩崎一弘、山口壹範、島礼、宮城妙子
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  宮城県・仙台市
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-26430130
[Presentation] 起源細胞でのPKMスイッチが、腫瘍細胞のブドウ糖代謝様式を規定する2016
- Author(s)
  盛田麻美、野村美有樹、坂本良美、伊藤しげみ、井上維、佐藤郁郎、田中遼太、松本祥子、岸本綾子、渡邊利雄、島礼、田沼延公
- Organizer
  第10回オートファジー研究会
- Place of Presentation
  新潟県・越後湯沢
- Year and Date
  2016-11-13
- Data Source
  KAKENHI-PROJECT-26430130
[Presentation] 新規皮膚がん抑制遺伝子Ppp6c変異は、変異型K-RASによる腫瘍発生を強く促進する2016
- Author(s)
  黒沢是之、後藤孝浩、島礼、館正
- Organizer
  第25回日本形成外科学会基礎学術集会
- Place of Presentation
  大阪府・大阪市
- Year and Date
  2016-09-15
- Data Source
  KAKENHI-PROJECT-26430130
[Presentation] 起源細胞でのPKMスイッチが、腫瘍細胞のブドウ糖代謝様式を規定する2016
- Author(s)
  盛田麻美、野村美有樹、坂本良美、伊藤しげみ、井上維、佐藤郁郎、田中遼太、松本祥子、岸本綾子、渡邊利雄、島礼、田沼延公
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  神奈川県・横浜市
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-26430130
[Presentation] 小細胞肺がんにおける新規分子標的の開拓2016
- Author(s)
  盛田麻美、野村美有樹、坂本良美、佐藤郁郎、島礼、前門戸任、田沼延公
- Organizer
  第８２回日本生化学会東北支部例会
- Place of Presentation
  青森県・弘前市
- Year and Date
  2016-05-21
- Data Source
  KAKENHI-PROJECT-26430130
[Presentation] 遺伝子改変マウスを用いたArf1の胚発生での機能と神経系での機能の解析の試み2016
- Author(s)
  渡邊利雄、薗部なな子、生田優希、小河穂波、宮本可南子、丹賀直美、鈴木麻衣、西川紗織、新谷隆史、島礼
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  宮城県・仙台市
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-26430130
[Presentation] 小細胞肺がんにおけるPyruvate kinase Mの発現と機能解析2016
- Author(s)
  盛田麻美、野村美有樹、坂本良美、伊藤しげみ、佐藤郁郎、島礼、前門戸任、田沼延公
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  宮城県・仙台市
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-26430130
[Presentation] 脱リン酸化酵素PP6の触媒サブユニットのPpp6cは着床後の胚の正常な発生に不可欠である。2016
- Author(s)
  小河穂波、田沼延広、早川夏姫、住吉麻実、鈴木麻衣、井上唯、野村美有樹、島礼、渡邊　利雄
- Organizer
  第７回　プロテインホスファターゼ研究会学術集会
- Place of Presentation
  自然科学研究機構（愛知県、岡崎市）
- Year and Date
  2016-01-29
- Data Source
  KAKENHI-PROJECT-26430130
[Presentation] 脱リン酸化酵素PP6は、皮膚がん抑制遺伝子である2016
- Author(s)
  黒沢是之、桃井勇貴、井上唯、小河穂波、後藤孝浩、田沼延公、渡邊利雄、島礼
- Organizer
  第７回　プロテインホスファターゼ研究会学術集会
- Place of Presentation
  自然科学研究機構（愛知県、岡崎市）
- Year and Date
  2016-01-29
- Data Source
  KAKENHI-PROJECT-26430130
[Presentation] Pyruvate kinase Mの両isoformを欠損するマウスの解析2016
- Author(s)
  田中遼太、小河穂波、井上維、山下洋二、三浦康、河合賢郎、佐藤郁郎、渡邊利雄、島礼、田沼延公
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  宮城県・仙台市
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-26430130
[Presentation] 新規皮膚がん抑制遺伝子Ppp6c変異は、変異型K-RASによる腫瘍発生を強く促進する2016
- Author(s)
  黒沢是之、田沼延公、角川陽一郎、山下洋二、三浦康、山田秀和、佐藤郁郎、野村美有樹、渡利雄、島礼
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  神奈川県・横浜市
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-15K10081
[Presentation] "プロテインホスファターゼ6型(PP6)は、皮膚がん抑制遺伝子として働く2016
- Author(s)
  井上維、黒沢是之、小河穂波、加藤浩之、林克剛、野村美有樹、田沼延公、渡邊利雄、島礼
- Organizer
  平成27年度　個体レベルでのがん研究支援活動　ワークショップ
- Place of Presentation
  琵琶湖ホテル（滋賀県・大津市）
- Year and Date
  2016-02-03
- Data Source
  KAKENHI-PROJECT-26430130
[Presentation] Arf GTPase活性化因子SMAP2の欠損はEGFの取り込み後の輸送の異常を引き起こすのか2015
- Author(s)
  大塚瑞希、住吉麻実、増田成美、早川夏姫、小河穂波、田沼延広、島礼、渡邊利雄
- Organizer
  BMB2015 (第３８回日本分子生物学会年会　第８８回日本生化学会大会合同大会）
- Place of Presentation
  神戸ポートアイランド（兵庫県・神戸市）
- Year and Date
  2015-11-30
- Data Source
  KAKENHI-PROJECT-26430130
[Presentation] 大腸癌における天然物を用いた抗がん剤開発の現況2015
- Author(s)
  三浦康、島礼、佐藤賢一、山口壹範、田沼延公、角川陽一郎、佐藤正幸、木内誠、山本久仁治、長谷川康弘、河合賢朗、大沼忍、藤谷恒明
- Organizer
  第74回　日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場(愛知県・名古屋市）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-15K10081
[Presentation] PP6 deficiency potentiates ultraviolet-B-induced skin carcinogenesis2015
- Author(s)
  Yui Inoue, Hiroyuki Kato, Koreyuki Kurosawa, Nobuhiro Tanuma, Honami Ogoh, Toshio Watanabe, and Hiroshi Shima
- Organizer
  10th Mechanisms and Models of Cancer 2015
- Place of Presentation
  San Diego (USA)
- Year and Date
  2015-08-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26430130
[Presentation] 皮膚Ppp6c欠損マウスは、UVB誘導皮膚扁平上皮発がんに高感受性となる2015
- Author(s)
  加藤浩之、田沼延公、三浦康、角川陽一郎、椎葉健一、山下洋二、林克剛、野村美有樹、佐藤郁郎、伊藤しげみ、渡邊利雄、島礼
- Organizer
  第74回　日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場(愛知県・名古屋市）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-26430130
[Presentation] 皮膚Ppp6c欠損マウスは、UVB誘導皮膚扁平上皮発がんに高感受性となる2015
- Author(s)
  加藤浩之、田沼延公、三浦康、角川陽一郎、椎葉健一、山下洋二、林克剛、野村美有樹、佐藤郁郎、伊藤しげみ、渡邊利雄、島礼
- Organizer
  第74回　日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場(愛知県・名古屋市）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-26670611
[Presentation] 皮膚Ppp6c欠損マウスは、UVB誘導皮膚扁平上皮発がんに高感受性となる2015
- Author(s)
  加藤浩之、田沼延公、三浦康、角川陽一郎、椎葉健一、山下洋二、林克剛、野村美有樹、佐藤郁郎、伊藤しげみ、渡邊利雄、島礼
- Organizer
  第74回　日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場(愛知県・名古屋市）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-15K10081
[Presentation] 大腸癌における天然物を用いた抗がん剤開発の現況2015
- Author(s)
  三浦康、島礼、佐藤賢一、山口壹範、田沼延公、角川陽一郎、佐藤正幸、木内誠、山本久仁治、長谷川康弘、河合賢朗、大沼忍、藤谷恒明、
- Organizer
  第74回　日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場(愛知県・名古屋市）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-26430130
[Presentation] 皮膚Ppp6c欠損マウスは、化学発がんおよびUVB誘導発がんに高感受性となる2015
- Author(s)
  島礼、黒沢是之、井上唯、小河穂波、加藤浩之、田沼延公、渡邊利雄
- Organizer
  BMB2015 (第３８回日本分子生物学会年会　第８８回日本生化学会大会合同大会）
- Place of Presentation
  神戸ポートアイランド（兵庫県・神戸市）
- Year and Date
  2015-11-30
- Data Source
  KAKENHI-PROJECT-26430130
[Presentation] 紫外線誘導皮膚がんにおいて、PP6はがん抑制遺伝子として働く2015
- Author(s)
  黒沢是之、後藤孝浩、田沼延公、加藤浩之、佐藤郁郎、伊藤しげみ、島礼、館正弘
- Organizer
  第24回　日本形成外科学会基礎学術集会
- Place of Presentation
  岩手県民会館（岩手県・盛岡市）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-26430130
[Presentation] UVB照射により、Ppp6c欠損では、高頻度に皮膚扁平上皮癌が発生する2015
- Author(s)
  加藤浩之、田沼延公、黒沢是之、井上維、林克剛、小河穂波、野村美有樹、渡邊利雄,島礼
- Organizer
  第81回　日本化学会東北支部例会
- Place of Presentation
  東北大学さくらホール（宮城県・仙台市）
- Year and Date
  2015-05-09
- Data Source
  KAKENHI-PROJECT-26430130
[Presentation] 発がんに伴う、Pyruvate Kinase Mのアイソザイム変換-代謝再プログラム化における意義解明のための新規マウスモデル2014
- Author(s)
  坂本良美、野村美有樹、松本祥子、盛田麻美、田中遼太、島礼、渡邊利雄、田沼延公
- Organizer
  第6回日本プロテインホスファターゼ研究会学術集会
- Place of Presentation
  津
- Year and Date
  2014-02-20
- Data Source
  KAKENHI-PROJECT-24659621
[Presentation] ノックインモデルを用いた、ピルビン酸キナーゼM(PKM)アイソフォームの機能解析2013
- Author(s)
  坂本良美、渡邊利雄、野村美有樹、山下洋二、椎葉健一、佐藤郁郎、佐藤雅美、島礼、田沼延公
- Organizer
  第72回日本癌学会学術集会
- Place of Presentation
  横浜
- Year and Date
  2013-10-05
- Data Source
  KAKENHI-PROJECT-23592149
[Presentation] Ptprz gene encoding a transmembrene-type protein phosphatase is up-regulated by Sox-2 in glioma.2013
- Author(s)
  Yoji Yamashita,Nobuhiro Tanuma,Ichiro Shibahara,Yukihiro Sonoda,Masayuki Kanamori,Ryuta Saito,Toshihiro Kumabe,Teiji Tominaga,Hiroshi Shima,Ryuichi Katakura
- Organizer
  AACR ANNUAL MEETING 2013
- Place of Presentation
  Washington,DC
- Data Source
  KAKENHI-PROJECT-23592149
[Presentation] Generation of knock-in mice to dissect isoform-specific roles for each splicing isoform of pyruvate kinase M in vivo2013
- Author(s)
  松本祥子、坂本良美、野村美有樹、田中遼大、盛田麻美、伊藤しげみ、椎葉健一、野村栄樹、片倉隆一、山下洋二、佐藤郁郎、渡邊利雄、島礼、田沼延公
- Organizer
  第36回分子生物学会
- Place of Presentation
  神戸
- Year and Date
  2013-12-05
- Data Source
  KAKENHI-PROJECT-23592149
[Presentation] Embryonic Lethality Caused in Mice LPP6c gene2013
- Author(s)
  Ogoh H, Kishimoto A, Suzuki M, Hara K, Tanga N, Tanuma N, Watanabe T andShima H
- Organizer
  10th International Conference on Protein Phosphatase
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PROJECT-22590298
[Presentation] PKMアイソフォームに関する生理的、および病態生理的機能解析2013
- Author(s)
  坂本良美、松本祥子、渡邊利雄、近藤玄、野村美有樹、野村栄樹、椎葉健一、島礼、田沼延公
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  横浜
- Year and Date
  2013-09-11
- Data Source
  KAKENHI-PROJECT-24659621
[Presentation] Ptprz gene encoding a transmembrene-type protein phosphatase is up-regulated by Sox-2 in glioma2013
- Author(s)
  Yoji Yamashita, Nobuhiro Tanuma, Ichiro Shibahara, Yukihiro Sonoda, Masayuki Kanamori,Ryuta Saito, Toshihiro Kumabe, Teiji Tominaga, Hiroshi Shima, Ryuichi Katakura
- Organizer
  AACR ANNUAL MEETING 2013
- Place of Presentation
  Washington,DC
- Year and Date
  2013-04-06
- Data Source
  KAKENHI-PROJECT-23592149
[Presentation] ノックインモデルを用いた、ピルビン酸キナーゼM（PKM）アイソフォームの機能解析2013
- Author(s)
  坂本良美、渡邊利雄、野村美有樹、山下洋二、椎葉健一、佐藤郁郎、佐藤雅美、島礼、田沼延公
- Organizer
  第72回日本癌学会学術集会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23592149
[Presentation] Generation of knock-in mice to dissect isoform-specific roles for each splicing isoform of pyruvate kinase M in vivo2013
- Author(s)
  松本祥子、坂本良美、野村美有樹、田中遼大、盛田麻美、伊藤しげみ、椎葉健一、野村栄樹、片倉隆一、山下洋二、佐藤郁郎、渡邊利雄、島礼、田沼延公
- Organizer
  第36回分子生物学会
- Place of Presentation
  神戸
- Year and Date
  2013-12-05
- Data Source
  KAKENHI-PROJECT-24659621
[Presentation] ノックインモデルを用いた、ピルビン酸キナーゼM(PKM)アイソフォームの機能解析2013
- Author(s)
  坂本良美、渡邊利雄、野村美有樹、山下洋二、椎葉健一、佐藤郁郎、佐藤雅美、島礼、田沼延公
- Organizer
  第72回日本癌学会学術集会
- Place of Presentation
  横浜
- Year and Date
  2013-10-05
- Data Source
  KAKENHI-PROJECT-24659621
[Presentation] ノックインモデルを用いた、ピルビン酸キナーゼM（PKM）アイソフォームの機能解析2013
- Author(s)
  坂本良美、渡邊利雄、野村美有樹、山下洋二、椎葉健一、佐藤郁郎、佐藤雅美、島礼、田沼延公
- Organizer
  第72回日本癌学会学術集会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24659621
[Presentation] リン酸化によるスフライシング装置タンハクSap155/Sf3b1制御機構2012
- Author(s)
  島礼
- Organizer
  日本プロテインホスファターゼ研究会学術集会
- Place of Presentation
  大阪
- Year and Date
  2012-01-19
- Data Source
  KAKENHI-PROJECT-22590298
[Presentation] A mouse model incapable of switching PKM isoforms2012
- Author(s)
  田沼延公、渡邊利雄、野村美有樹、佐藤郁郎、椎葉健一、山下洋二、佐藤雅美、島礼
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Year and Date
  2012-09-20
- Data Source
  KAKENHI-PROJECT-22390272
[Presentation] PP6触媒サブユニット遺伝子は、胚の初期発生時期に必須である2012
- Author(s)
  渡邊利雄、田沼延公、島礼
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-22590298
[Presentation] A mouse model incapable of switching PKM isoforms2012
- Author(s)
  田沼延公、山下洋二、島礼、渡邊利雄
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Year and Date
  2012-09-20
- Data Source
  KAKENHI-PROJECT-23592149
[Presentation] ピルビン酸キナーゼM(PKM)の発現アイソフォーム固定したマウスの作出2012
- Author(s)
  田沼延公、岸本綾子、松本祥子、野村美有樹、近藤玄、国下侑里、片倉隆一、佐藤雅美、渡邊利雄、島礼
- Organizer
  第85回日本生化学会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22590298
[Presentation] リン酸化によるスプライシング装置タンパク Sap155/Sf3b1 制御機構2012
- Author(s)
  島礼
- Organizer
  日本プロテインホスファターゼ研究会学術集会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-23592149
[Presentation] ワールブルグ効果に関するin vivo解析のためのマウスモデル開発2012
- Author(s)
  松本祥子、岸本綾子、国下侑里、近藤玄、野村美有樹、渡邊利雄、島礼、田沼延公
- Organizer
  第35回日本分子生物学会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22590298
[Presentation] PP6c 遺伝子は胚の初期発生時期に必須である2012
- Author(s)
  島礼
- Organizer
  日本プロテインホスファターゼ研究会学術集会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-23592149
[Presentation] ピルビン酸キナーゼM2はダイオキシン受容体の活性化補助因子である2012
- Author(s)
  松田俊、足立淳、井原賢、田沼延公、島礼、井倉正枝、井倉毅、松田知成
- Organizer
  第35回日本分子生物学会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22590298
[Presentation] 第2次肺癌検診喀痰細胞診合同委員会活動状況報告2012
- Author(s)
  佐藤雅美、斎藤泰紀,佐藤之俊,柴光年,渋谷潔,土田敬明,中山富雄,池田徳彦,三浦弘之,田中良太,河原栄,中嶋隆太郎,神尾淳子,島垣二佳子,田口明美,長尾緑,岡上愼一,三宅真司,矢羽田一信
- Organizer
  第51回日本臨床細胞学会秋期大会
- Place of Presentation
  新潟
- Year and Date
  2012-11-10
- Data Source
  KAKENHI-PROJECT-22390272
[Presentation] ES細胞におけるピルビン酸キナーゼM(PKM)アイソフォームの機能解析‐ノックイン細胞を用いて2012
- Author(s)
  田沼延公、岸本綾子、国下侑里、松本祥子、近藤玄、坂本良美、野村美有樹、渡邊利雄、島礼
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22590298
[Presentation] PKMスイッチ不可能なマウスモデル2012
- Author(s)
  田沼延公、渡邊利雄、野村美有樹、佐藤郁郎、椎葉健一、山下洋二、佐藤雅美、島礼
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-22590298
[Presentation] 悪性グリオーマ検体およびグリオーマ樹立株におけるPTPzetaの解析2012
- Author(s)
  山下洋二、春日井勲、田沼延公、柴原一陽、園田順彦、金森政之、齋藤竜太、隅部俊宏、冨永悌二、島礼、片倉隆一
- Organizer
  脳神経外科学会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-22590298
[Presentation] PP6c遺伝子は胚の初期発生時期に必須である2012
- Author(s)
  島礼
- Organizer
  日本プロテインホスファターゼ研究会学術集会
- Place of Presentation
  大阪
- Year and Date
  2012-01-19
- Data Source
  KAKENHI-PROJECT-22590298
[Presentation] Protein Phosphatases in human Glioma Samples2011
- Author(s)
  Hiroshi Shima
- Organizer
  The first Japan-Taiwan Bilateral Conference on Protein Phosphatases
- Place of Presentation
  Okazaki
- Data Source
  KAKENHI-PROJECT-23592149
[Presentation] Phospho-Regulation of Splicesomal Protein, Sap155/Sf3b12011
- Author(s)
  Tanuma N, Nomura M, Sato M, Yamashita Y, Shiiba K, Katakura K, and ShimaH
- Organizer
  9th International Conference on Protein Phosphatase & Ist International Symposium on Carcinogenic Spiral
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PROJECT-22590298
[Presentation] グリオーマにおけるピルビン酸キナーゼM(PKM)スプライシングのスイッチ機構2011
- Author(s)
  島礼
- Organizer
  第29回日本脳腫瘍学会学術集会
- Place of Presentation
  下呂
- Year and Date
  2011-11-28
- Data Source
  KAKENHI-PROJECT-22590298
[Presentation] Protein Phosphatases in human Glioma Samples2011
- Author(s)
  島礼
- Organizer
  The First Japan-Taiwan Bilateral Conference on protein phosphatases
- Place of Presentation
  岡崎(招待講演)
- Year and Date
  2011-12-02
- Data Source
  KAKENHI-PROJECT-22590298
[Presentation] 「グリオーマにおけるピルビン酸キナーゼＭ（ＰＫＭ）スプライシングのスイッチ機構」2011
- Author(s)
  山下洋二,島礼
- Organizer
  日本脳神経外科学会　第70回学術総会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-23592149
[Presentation] Protein Phosphatases in human Glioma Samples2011
- Author(s)
  Shima H
- Organizer
  The first Japan-Taiwan Bilateral Conference on Protein Phosphatases
- Place of Presentation
  Okazaki
- Year and Date
  2011-12-02
- Data Source
  KAKENHI-PROJECT-22590298
[Presentation] Switch of pyruvate kinase M (PKM) isoforms in human breast cancers2011
- Author(s)
  野村美有樹、田沼延公、角川陽一郎、島礼
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22590298
[Presentation] Phospho-Regulation of Spliceosomal Protein, Sap155/Sf3b1.2011
- Author(s)
  島礼
- Organizer
  9^<th> International Conference on Protein Phosphatrase
- Place of Presentation
  東京
- Year and Date
  2011-02-01
- Data Source
  KAKENHI-PROJECT-22590298
[Presentation] Analysis of Protein Phosphatases in Human Glioma Samples2011
- Author(s)
  Shima H
- Organizer
  9th International Conference on Protein Phosphatase & Ist International Symposium on Carcinogenic Spiral
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PROJECT-22590298
[Presentation] Embryonic Lethality Caused in Mice Lacking the phosphatase domain of the PP6c gene2011
- Author(s)
  島礼
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2011-12-16
- Data Source
  KAKENHI-PROJECT-22590298
[Presentation] グリオーマにおけるピルビン酸キナーゼM(PKM)スプライシングのスイッチ機構2011
- Author(s)
  島礼
- Organizer
  日本脳神経外科学会第70回学術総会
- Place of Presentation
  横浜
- Year and Date
  2011-10-13
- Data Source
  KAKENHI-PROJECT-22590298
[Presentation] Embryonic Lethality Caused in Mice Lacking the phosphatase domain of thePP6c gene2011
- Author(s)
  Kishimoto A, Tanuma N, Suzuki M, Sasaki, N Abe T, Kiyonari H, Aizawa S-i,Watanabe T, Shima H
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22590298
[Presentation] Analysis of Protein Phosphatases in Human Glioma Patients.2011
- Author(s)
  島礼
- Organizer
  9^<th> International Conference on Protein Phosphatrase
- Place of Presentation
  東京
- Year and Date
  2011-02-01
- Data Source
  KAKENHI-PROJECT-22590298
[Presentation] Conversion of pyruvate kinase M (PKM) isozymes in human cancers - an analysis using isoform-specific antibodies2010
- Author(s)
  野村美有樹、田沼延公、佐々木希、島礼
- Organizer
  BMB 2010 第33回日本分子生物学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22590298
[Presentation] Drift of pyruvate kinase M (PKM) alternative splicing associating with Warburg effect in human cancers2010
- Author(s)
  田沼延公、野村美有樹、大内司、佐藤雅美、片倉隆一、島礼
- Organizer
  BMB 2010 第33回日本分子生物学会年会、第83回日本生化学学会大会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22590298
[Presentation] Aberrant pre-mRNA splicing of pyrubate kinase M (PKM) in human cancer2010
- Author(s)
  田沼延公、野村美有樹、山下洋二、椎葉健一、角川陽一郎、佐藤郁郎、島礼
- Organizer
  第69回日本癌学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22590298
[Presentation] Drift of pyruvate kinase M (PKM) alternative splicing associating with Warburg effect in human cancers.2010
- Author(s)
  島礼
- Organizer
  BMB2010 第33回日本分子生物学会年会第83回日本生化学学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2010-12-08
- Data Source
  KAKENHI-PROJECT-22590298
[Presentation] Conversion of pyruvate kinase M (PKM) isozymes in human canters-an analysis using isoform-specific antibodies2010
- Author(s)
  島礼
- Organizer
  BMB2010 第33回日本分子生物学会年会第83回日本生化学学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2010-12-10
- Data Source
  KAKENHI-PROJECT-22590298
[Presentation] Generation of isoform-specific antibodies against pyruvate kinase (PKM)2010
- Author(s)
  野村美有樹、田沼延公、山下洋二、椎葉健一、角川陽一郎、佐藤郁郎、島礼
- Organizer
  第69回日本癌学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22590298
[Presentation] 脳腫瘍におけるホスファトーム異常の解析2009
- Author(s)
  島礼
- Organizer
  日本プロテインホスファターゼ研究学術集会
- Place of Presentation
  熊本市
- Year and Date
  2009-11-13
- Data Source
  KAKENHI-PROJECT-20659227
[Presentation] 脳腫瘍におけるホスファトーム異常の解析2009
- Author(s)
  島礼
- Organizer
  第4回日本プロテインホスファターゼ研究学術集会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-20591730
[Presentation] Dusp26 Associates with KIF3 Motor and Promotes Cadherin-Mediated Cell-Cell Adhesion EUROPHOSPHATASE 20092009
- Author(s)
  Miyuki Nomura, Nobuhiro Tanuma, Isao Kasugai, Masami Sato, Hiroshi Shima
- Organizer
  Protein phosphatases in development and disease, Egmond aan Zee
- Place of Presentation
  The Netherlands
- Year and Date
  2009-07-16
- Data Source
  KAKENHI-PROJECT-19390370
[Presentation] NIPP1 Directs PP1 to Dephosphorylate the Essential Pre-mRNA Splicing Factor, Sap 1552008
- Author(s)
  Nobuhiro Tanuma, Kunimi Kikuchi, Hiroshi Shima
- Organizer
  8th International Conference on Cellular Regulation by Protein Phosphatases "Protein Phosphatases: From Genome to Disease"
- Place of Presentation
  Maebashi, Japan
- Data Source
  KAKENHI-PROJECT-19570142
[Presentation] PP1/NIPP1複合体によるU2snRNP の Sap155/Sf3b1構成タンパクSap155/Sf3b1の脱リン酸化2008
- Author(s)
  島礼
- Organizer
  BMB2008シンポジウム
- Place of Presentation
  神戸
- Year and Date
  2008-12-10
- Data Source
  KAKENHI-PROJECT-19570142
[Presentation] ホスファターゼPP1-NIPP1ホロ酵素によるU2snRNPのSap155/Sf3b1サブユニットの脱リン酸化 Phosphatase PP1-NIPP1 holoenzyme de-phosphorylates Sap155/Sf3b1 of U2snRNP2008
- Author(s)
  田沼延公、野村美有樹、島礼
- Organizer
  第67回日本癌学会総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-19570142
[Presentation] プロテインホスファターゼPP1/NIPP1複合体によるSap155/Sf3b1の脱リン酸化とsplicing制御機構2008
- Author(s)
  田沼延公、椿耶緒、野村美有樹、菊池九二三、島礼
- Organizer
  BMB2008第31回日本分子生物学会第81回日本生化学会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-19570142
[Presentation] DUSP26によるキネシンモーターKIF3の制御およびCadherin 依存性細胞接着の亢進2008
- Author(s)
  野村美有樹、田沼延公、池田正稔、春日井勲、菊池九二三、島礼
- Organizer
  BMB2008第31回日本分子生物学会第81回日本生化学会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-19570142
[Presentation] PP1/NIPP1複合体によるU2snRNPのSap155/Sf3b1構成タンパク、Sap155/Sf3b1の脱リン酸化2008
- Author(s)
  田沼延公、椿耶緒、野村美有樹、菊池九二三、島礼
- Organizer
  BMB2008第31回日本分子生物学会第81回日本生化学会合同大会シンポジウム「3S22ホスファターゼスーパーファミリーの機能と異常:ゲノムから疾患まで」
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-19570142
[Presentation] DUSP26はKIF3Aと結合しKAP3の脱リン酸化を促進する2008
- Author(s)
  野村美有樹、田沼延公、高垣謙太郎、島礼
- Organizer
  第67回日本癌学会総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-19570142
[Presentation] Function of MKP-7,at chromosome 12p,towards MAPK cascade2007
- Author(s)
  島礼
- Organizer
  Mechanisms and Models of Cancer Meeting
- Place of Presentation
  サンディェゴ/米国
- Year and Date
  2007-08-10
- Data Source
  KAKENHI-PROJECT-19570142
[Presentation] 二重基質特異性ホスファターゼLDP-4とキネシンの結合2007
- Author(s)
  野村美有樹,田沼延公,高垣謙太郎,菊池九二三,島礼
- Organizer
  BMB2007第30回日本分子生物学会第80回日本生化学会合同大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19570142
[Presentation] NIPP1-PP1cホロ酵素によるU2snRNPコンポーネントSap155/SF3b1の脱リン酸化2007
- Author(s)
  田沼延公,金世殷,椿耶緒,島礼,三橋進也,野村美有樹,菊池九二三
- Organizer
  BMB2007第30回日本分子生物学会第80回日本生化学会合同大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19570142
[Presentation] Low-molecular-mass dual specificity phosphatase-4(LDP-4) functions as an activator of JNK and p38.2007
- Author(s)
  野村美有樹、高垣謙太郎、田沼延公、菊池九二三、島礼
- Organizer
  第66回日本癌学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19570142
[Presentation] LDP-4, a cancer-associated dual-specificity protein phosphatase binds kinesine2007
- Author(s)
  田沼延公、高垣謙太郎、野村美有樹、菊池九二三、島礼
- Organizer
  第66回日本癌学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19570142
[Presentation] PP1 de-regulation by a mutant form of NIPP1 lacking the C-terminal region2007
- Author(s)
  Nobuhiro Tanuma, Shinya Mitsuhashi, Miyuki Nomura, Yao Tsubaki, Sei-Eun Kim, Kunimi Kikuchi, Hiroshi Shima
- Organizer
  EUROPHOSPHATASES 2007, Protein Phosphatases in Health and Disease
- Place of Presentation
  Aveiro, Portugal
- Data Source
  KAKENHI-PROJECT-19570142
[Presentation] Characterization of LDP-4, a cancer-associated dual-specificity phosphatase2007
- Author(s)
  Miyuki Nomura, Kentaro Takagaki, Nobuhiro Tanuma, Kumimi Kikuchi, Hiroshi Shima
- Organizer
  EUROPHOSPHATASES 2007, Protein Phosphatases in Health and Disease
- Place of Presentation
  Aveiro, Portugal
- Data Source
  KAKENHI-PROJECT-19570142
[Presentation] Function of MKP-7, at chromosome 12p, towards MAPK cascade2007
- Author(s)
  Hiroshi Shima, Chiaki Katagiri, Kouhei Masuda, Miyuki Nomura, Isao Kasugai, Nobuhiro Tanuma
- Organizer
  Mechanisms and Models of Cancer Meeting
- Place of Presentation
  San Diego
- Data Source
  KAKENHI-PROJECT-19570142

1. TANUMA Nobuhiro (40333645)

# of Collaborated Projects: 13 results

# of Collaborated Products: 43 results
2. KIKUCHI Kunimi (20006117)

# of Collaborated Projects: 11 results

# of Collaborated Products: 10 results
3. YAMASHITA Yoji (30420045)

# of Collaborated Projects: 6 results

# of Collaborated Products: 31 results
4. Sato Ikurou (50225918)

# of Collaborated Projects: 6 results

# of Collaborated Products: 42 results
5. NOMURA Miyuki (40390893)

# of Collaborated Projects: 5 results

# of Collaborated Products: 22 results
6. KAKUGAWA YOICHIRO (60221173)

# of Collaborated Projects: 4 results

# of Collaborated Products: 5 results
7. 日野田裕治 (10165128)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
8. 田村眞理 (20124604)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
9. 武田誠郎 (40030853)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
10. SHIIBA KENITI (90196345)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
11. NAKAMURA Kouji (70281839)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. SATO Masami (30250830)

# of Collaborated Projects: 2 results

# of Collaborated Products: 12 results
13. Kawai Masaaki (80513530)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
14. 菅沼雅美 (20196695)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
15. SASAKI Nozomi (50467429)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. YOKOYAMA Masayuki (20220577)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. SONODA Yukihiko (90302140)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
18. NAKAMURA Yoshihiro (60381159)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
19. SAKASEGAWA Koichi (80601393)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
20. OTSUKA Tsunayuki (40464466)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
21. NAGATA Toshiyuki (70611763)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
22. AOKI Masaya (50624996)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
23. WATANABE Tosio (60201208)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. SUGAMURA Kazuo (20117360)

# of Collaborated Projects: 1 results

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25. FUKAMACHI Kayoko (00626137)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. NISHINO Yoshikazu (70302099)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. YAMADA Hidekazu (10254012)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
28. Yamashita Katsumi (10191280)

# of Collaborated Projects: 1 results

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29. MOCHISDA Satoru (60590304)

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30. Abe Jiro (10573686)

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31. 柳田充弘 (80025428)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. 片倉隆一 (10442675)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. 伊藤しげみ (80600006)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
34. 安田純 (00281684)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
35. 盛田麻美 (20647193)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
36. 佐藤卓 (90814541)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
37. 望月麻衣 (40726303)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
38. 加藤浩之 (90770347)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
39. YOSHIOKA Katsuji

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
40. YOSHIMARU Tetsuro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
41. YAMAGUCHI Kazunori

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
42. TAMAI Keiichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
43. 伊藤信

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
44. 堀井明

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
45. 三好康雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
46. 片桐豊雅

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
47. 松井秀俊

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
48. 渡辺利雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 9 results
49. 本橋ほづみ

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
50. 西田基宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
51. 藤井重元

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
52. 赤池孝章

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
53. 松村到

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
54. 田中宏和

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
55. 森田真吉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
56. 宮城妙子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
57. 松居靖久

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
58. 前門戸任

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

SHIMA Hiroshi 島 礼

島 礼 シマ ヒロシ

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Tumorigenesis due to dysfunction of PP6, a novel target for cancer treatment.Principal Investigator

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Tumor promotion associated with Ppp6c-deficiency.Principal Investigator

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SHIMA Hiroshi 島礼

島礼シマヒロシ