YAMASHITA Yoji 山下洋二

… Alternative Names

山下洋二ヤマシタヨウジ

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Researcher Number	30420045
Affiliation (Current)	2023: 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん薬物療法研究部, 特任研究員
Affiliation (based on the past Project Information) *help	2023: 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん薬物療法研究部, 特任研究員 2011 – 2021: 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん薬物療法研究部, 特任研究員 2010: 宮城県がんセンター研究所, 特任研究員 2010: Miyagi Cancer Center Research Institute, 研究所, 特任研究員 2009 – 2010: 宮城県がんセンター, 研究所, 特任研究員 … More 2007 – 2010: Miyagi Cancer Center Research Institute, 生化学部, 特任研究員 2008: 宮城県がんセンター(研究所), 脳神経外科, 主任医長 2008: 東北大学, 宮城県立がんセンター・研究所, 特任研究員 2007: 宮城県立がんセンター, 研究所, 特任研究員 2006: 東北大学, 病院, 助手 Less
Review Section/Research Field	Principal Investigator Cerebral neurosurgery / Basic Section 56010:Neurosurgery-related / Neurosurgery Except Principal Investigator Cerebral neurosurgery / Basic Section 49030:Experimental pathology-related / Tumor biology / Tumor biology / Pathological medical chemistry / Biological Sciences
Keywords	Principal Investigator グリオーマ / 脳腫瘍学 / 代謝 / 化学療法 / ノックアウト / 鉄 / CDC25A / glioma / プロテインホスファターゼ6型 / 悪性グリオーマ … More / プロテインホスファターゼ / 腫瘍マーカー / 解糖系酵素 / スプライシング / PKM / ワールブルグ効果 / 解糖系 … More Except Principal Investigator プロテインホスファターゼ / KRAS / Trp53 / Kras / 膵がん / ドライバー変異 / ゲノム不安定性 / DNA修復 / 炎症 / がん / スプライシング / ワールブルグ効果 / 代謝 / PKM / 癌 / 2重基質ボスファターゼ / 2重基質ホスファターゼ / ２重基質ホスファターゼ / ホスファターゼ / KIF3 / キネシンモーター / 分子腫瘍学 / Temozolomide / ACNU / CED法 / MGMT / 薬剤耐性 / MGMT CED法 / 膠芽腫 / DDS / ターゲティング / 抗がん剤 / 高分子ミセル / 脳腫瘍 / CED / 化学療法 / 脳腫瘍学 Less

悪性神経膠腫における鉄関連メタボリズムの役割Principal Investigator
- Principal Investigator
  
  山下洋二
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Miyagi Prefectural Hospital Organization Miyagi Cancer Center
変異型KRASによる腫瘍化を抑えるがん抑制遺伝子の同定（膵臓がんへの関与）
- Principal Investigator
  
  佐藤郁郎
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Miyagi Prefectural Hospital Organization Miyagi Cancer Center
A novel molecularly-targeted therapy for IDH-mutant gliomas.Principal Investigator
- Principal Investigator
  
  Yamashita Youji
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Miyagi Prefectural Hospital Organization Miyagi Cancer Center
Identification of a protein phosphatase which involved in brain tumororigenesis.Principal Investigator
- Principal Investigator
  
  Yamashita Yoji
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurosurgery
- Research Institution
  Miyagi Prefectural Hospital Organization Miyagi Cancer Center
Tumor promotion associated with Ppp6c-deficiency.
- Principal Investigator
  
  SHIMA Hiroshi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor biology
- Research Institution
  Miyagi Prefectural Hospital Organization Miyagi Cancer Center
Roles for pyruvate kinase M in tumorigenesis
- Principal Investigator
  
  TANUMA NOBUHIRO
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor biology
- Research Institution
  Miyagi Prefectural Hospital Organization Miyagi Cancer Center
Development of a novel therapy by targeting Warburg effect of gliomas.Principal Investigator
- Principal Investigator
  
  YAMASHITA YOUZI
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Miyagi Cancer Center Research Institute
Regulation of KIF3 motor by dephosphorylation
- Principal Investigator
  
  SHIMA Hiroshi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Miyagi Cancer Center Research Institute
CED法と高分子ミセルキャリヤーを用いた新規脳腫瘍化学療法システム
- Principal Investigator
  
  YOKOYAMA Masayuki
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Jikei University School of Medicine
  Kanagawa Academy of Science and Technology
Convection-enhanced delivery of ACNU with systemic administration of temozolomide
- Principal Investigator
  
  SONODA Yukihiko
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Tohoku University
Therapeutic effect of the polymeric micellar antineoplastic drugs infused convection-enhanced delivery against intracranial rat glioma modelsPrincipal Investigator
- Principal Investigator
  
  YAMASHITA Yoji
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Miyagi Cancer Center Research Institute
ドキソルビシン・リポソームの対流強化輸送法への応用
- Principal Investigator
  
  隈部俊宏
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Tohoku University
ドキソルビシンリポソームCED・テモゾロマイド全身投与併用による膠芽腫新規治療法Principal Investigator
- Principal Investigator
  
  山下洋二
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Miyagi Cancer Center Research Institute
  Tohoku University

All 2022 2021 2020 2018 2017 2016 2015 2013 2012 2011 2010 2009 2008 2007 Other

All Journal Article Presentation

[Journal Article] Clinicopathological risk factors for a poor prognosis of primary central nervous system lymphoma in elderly patients in the Tohoku and Niigata area: a multicenter, retrospective, cohort study of the Tohoku Brain Tumor Study Group2022
- Author(s)
  Asano K, Yamashita Y, Ono T, Natsumeda M, Beppu T, Matsuda K, Ichikawa M, Kanamori M, Matsuzaka M, Kurose A, Fumoto T, Saito K, Sonoda Y, Ogasawara K, Fujii Y, Shimizu H, Ohkuma H, Kitanaka C, Kayama T, Tominaga T.
- Journal Title
  
  Brain Tumor Pathol
  
  Volume: 印刷中 Issue: 3 Pages: 139-150
- DOI
  10.1007/s10014-022-00427-4
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10888, KAKENHI-PROJECT-19K09469, KAKENHI-PROJECT-20K07442, KAKENHI-PROJECT-20K08004
[Journal Article] The Real-World status and risk factors for a poor prognosis in elderly patients with primary central nervous system malignant lymphomas: a multicenter, retrospective cohort study of the Tohoku Brain Tumor Study Group2022
- Author(s)
  Asano K, Yamashita Y, Ono T, Natsumeda M, Beppu T, Matsuda K, Ichikawa M, Kanamori M, Matsuzaka M, Kurose A, Saito K, Sonoda Y, Ogasawara K, Fujii Y, Shimizu H, Ohkuma H, Kitanaka C, Kayama T, Tominaga T.
- Journal Title
  
  Int J Clin Oncol
  
  Volume: 27 Issue: 1 Pages: 77-94
- DOI
  10.1007/s10147-021-02042-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10888, KAKENHI-PROJECT-19K09469, KAKENHI-PROJECT-20K07442, KAKENHI-PROJECT-20K08004
[Journal Article] PP6 deficiency in mice with KRAS mutation and Trp53 loss promotes early death by PDAC with cachexia-like features.2022
- Author(s)
  Fukui K, Nomura M, Kishimoto K, Tanuma N, Kurosawa K, Kanazawa K, Kato H, Sato T, Miura S, Miura K, Sato I, Tsuji H, Yamashita Y, Tamai K, Watanabe T, Yasuda J, Tanaka T, Satoh K, Furukawa T, Jingu K, Shima H.
- Journal Title
  
  Cancer Sci.
  
  Volume: 印刷中 Issue: 5 Pages: 1613-1624
- DOI
  10.1111/cas.15315
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09469, KAKENHI-PROJECT-20K06545, KAKENHI-PROJECT-21K19420, KAKENHI-PROJECT-21K19748
[Journal Article] Ppp6c deficiency accelerates K-rasG12D -induced tongue carcinogenesis.2021
- Author(s)
  Kishimoto K, Kanazawa K, Nomura M, Tanaka T, Shigemoto-Kuroda T, Fukui K, Miura K, Kurosawa K, Kawai M, Kato H, Terasaki K, Sakamoto Y, Yamashita Y, Sato I, Tanuma N, Tamai K, Kitabayashi I, Matsuura K, Watanabe T, Yasuda J, Tsuji H, Shima H.
- Journal Title
  
  Cancer Med.
  
  Volume: 10(13) Issue: 13 Pages: 4451-4464
- DOI
  10.1002/cam4.3962
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09109, KAKENHI-PROJECT-20K17365, KAKENHI-PROJECT-20K06545, KAKENHI-PROJECT-20K07436, KAKENHI-PROJECT-21K19420, KAKENHI-PROJECT-21K19748, KAKENHI-PROJECT-21K15425
[Journal Article] Ppp6c haploinsufficiency accelerates UV-induced BRAF(V600E)-initiated melanomagenesis.2021
- Author(s)
  Kanazawa K, Kishimoto K, Nomura M, Kurosawa K, Kato H, Inoue Y, Miura K, Fukui K, Yamashita Y, Sato I, Tsuji H, Watanabe T, Tanaka T, Yasuda J, Tanuma N, Shima H
- Journal Title
  
  Cancer Sci.
  
  Volume: in press Issue: 6 Pages: 2233-2244
- DOI
  10.1111/cas.14895
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09469, KAKENHI-PROJECT-19K18757, KAKENHI-PROJECT-20K17365, KAKENHI-PROJECT-20K06545, KAKENHI-PROJECT-20K07436, KAKENHI-PROJECT-21K15425
[Journal Article] Divergent metabolic responses dictate vulnerability to NAMPT inhibition in ovarian cancer2020
- Author(s)
  Kudo Kei、Nomura Miyuki、Sakamoto Yoshimi、Ito Shigemi、Morita Mami、Kawai Masaaki、Yamashita Yoji、Ito Kiyoshi、Yamada Hidekazu、Shima Hiroshi、Yaegashi Nobuo、Tanuma Nobuhiro
- Journal Title
  
  FEBS Letters
  
  Volume: 594 Issue: 9 Pages: 1379-1388
- DOI
  10.1002/1873-3468.13736
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K09469, KAKENHI-PROJECT-17K07187, KAKENHI-PROJECT-19K09109
[Journal Article] Phase I trial of convection-enhanced delivery of nimustine hydrochloride (ACNU) for brainstem recurrent glioma.2020
- Author(s)
  Saito R, Kanamori M, Sonoda Y, Yamashita Y, Nagamatsu K, Murata T, Mugikura S, Kumabe T,Wembacher-Schroeder E , Thomson R, Tominaga T
- Journal Title
  
  Neurooncol Adv.
  
  Volume: 2(1) Issue: 1 Pages: 1-9
- DOI
  10.1093/noajnl/vdaa033
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09469, KAKENHI-PROJECT-17H04299
[Journal Article] PKM1 Confers Metabolic Advantages and Promotes Cell-Autonomous Tumor Cell Growth.2018
- Author(s)
  M Morita, T Sato, M Nomura, Y Sakamoto, Y Inoue, R Tanaka, S Ito, K Kurosawa, K Yamaguchi, Y Sugiura, H Takizaki, Y Yamashita, R Katakura, I Sato, Y Okada, H Watanabe, G Kondoh, et al.
- Journal Title
  
  Cancer Cell
  
  Volume: 12 Issue: 3 Pages: 355-367
- DOI
  10.1016/j.ccell.2018.02.004
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07296, KAKENHI-PROJECT-16K09597, KAKENHI-PROJECT-16K10486, KAKENHI-PROJECT-17K19620, KAKENHI-PROJECT-17K16876, KAKENHI-PLANNED-25111006, KAKENHI-PROJECT-16H04730, KAKENHI-PROJECT-15K09237, KAKENHI-PROJECT-15K21098, KAKENHI-PROJECT-16K19745, KAKENHI-PROJECT-17K07187, KAKENHI-PUBLICLY-17H05534, KAKENHI-PUBLICLY-17H06011, KAKENHI-PROJECT-16K10774, KAKENHI-PROJECT-17K19606, KAKENHI-PLANNED-17H06301
[Journal Article] Indications for salvage surgery during treatment for intracranial germ cell tumors.2018
- Author(s)
  Kanamori M, Kumabe T, Watanabe M, Chonan M, Saito R, Yamashita Y, Ogawa Y, Sonoda Y, Tominaga T.
- Journal Title
  
  J Neurooncol.
  
  Volume: - Issue: 3 Pages: 601-607
- DOI
  10.1007/s11060-018-2827-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K10353, KAKENHI-PROJECT-16K10774
[Journal Article] Loss of protein phosphatase 6 in mouse keratinocytes enhances K-rasG12D-driven tumor promotion.2018
- Author(s)
  Kurosawa K, Inoue Y, Kakugawa Y, Yamashita Y, Kanazawa K, Kishimoto K, Nomura M, Momoi Y, Sato I, Chiba N, Suzuki M, Ogoh H, Yamada H, Miura K, Watanabe T, Tanuma N, Tachi M, and Shima H
- Journal Title
  
  Cancer Science
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10774
[Journal Article] Loss of protein phosphatase 6 in mouse keratinocytes enhances K-ras G12D -driven tumor promotion2018
- Author(s)
  Kurosawa Koreyuki、Inoue Yui、Kakugawa Yoichiro、Yamashita Yoji、Kanazawa Kosuke、Kishimoto Kazuhiro、Nomura Miyuki、Momoi Yuki、Sato Ikuro、Chiba Natsuko、Suzuki Mai、Ogoh Honami、Yamada Hidekazu、Miura Koh、Watanabe Toshio、Tanuma Nobuhiro、Tachi Masahiro、Shima Hiroshi
- Journal Title
  
  Cancer Science
  
  Volume: 109 Issue: 7 Pages: 2178-2187
- DOI
  10.1111/cas.13638
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07187, KAKENHI-PROJECT-17K10660, KAKENHI-PROJECT-18K16043, KAKENHI-PROJECT-16H04690, KAKENHI-PROJECT-16K07296, KAKENHI-PROJECT-16K10486, KAKENHI-PROJECT-16K10774, KAKENHI-PROJECT-17K16358, KAKENHI-PROJECT-17K16876
[Journal Article] Sialidase NEU3 defines invasive potential of human glioblastoma cells by regulating calpain-mediated proteolysis of focal adhesion proteins2017
- Author(s)
  Takahashi Kohta、Proshin Sergei、Yamaguchi Kazunori、Yamashita Yoji、Katakura Ryuichi、Yamamoto Koji、Shima Hiroshi、Hosono Masahiro、Miyagi Taeko
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - General Subjects
  
  Volume: 1861 Issue: 11 Pages: 2778-2788
- DOI
  10.1016/j.bbagen.2017.07.023
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10774, KAKENHI-PROJECT-17K07187
[Journal Article] Abrogation of protein phosphatase 6 promotes skin carcinogenesis induced by DMBA2015
- Author(s)
  Hayashi K, Momoi Y , Tanuma N, Kishimoto A, Ogoh H, Kato H, Suzuki M, Sakamoto Y, Inoue Y, Nomura M, Kiyonari H, Sakayori M, Fukamachi K, Kakugawa Y, Yamashita Y, Ito S, Sato I, Suzuki A, Nishio M, Suganuma M, Watanabe T, and Shima H
- Journal Title
  
  Oncogene
  
  Volume: 印刷中 Issue: 35 Pages: 4647-55
- DOI
  10.1038/onc.2014.398
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24570159, KAKENHI-PROJECT-24591928, KAKENHI-PROJECT-25861168, KAKENHI-PROJECT-15K10081, KAKENHI-PROJECT-26430130, KAKENHI-PROJECT-15K19081, KAKENHI-PROJECT-15K20237, KAKENHI-PROJECT-25430163
[Journal Article] Loss of protein phosphatase 6 in mouse keratinocytes increases susceptibility to ultraviolet-B-induced carcinogenesis.2015
- Author(s)
  Kato H, Kurosawa K, Inoue Y, Tanuma N, Momoi Y, Hayashi K, Ogoh H, Nomura M, Sakayori M, Kakugawa Y, Yamashita Y, Miura K, Maemondo M, Katakura R, Ito S, Sato M, Sato I, Chiba N, Watanabe T, Shima H.
- Journal Title
  
  Cancer Lett.
  
  Volume: 365 Issue: 2 Pages: 223-228
- DOI
  10.1016/j.canlet.2015.05.022
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K09237, KAKENHI-PROJECT-15K10081, KAKENHI-PROJECT-26430130, KAKENHI-PROJECT-26461967, KAKENHI-PROJECT-15K14387, KAKENHI-PROJECT-15K19081, KAKENHI-PROJECT-15K20237, KAKENHI-PROJECT-25430163, KAKENHI-PROJECT-25670609
[Journal Article] Novel function of MKP-5/DUSP10, a phosphatase for stress-activated kinases, on ERK dependent gene expression, and up-regulation of its gene expression in colon carcinomas2012
- Author(s)
  Yoji Yamashita,Nobuhiro Tanuma
- Journal Title
  
  Oncology Reports
  
  Volume: 未定
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592149
[Journal Article] IDH 1/2 gene status defines the prognosis a nd molecular profiles in patients with grade III gliomas2012
- Author(s)
  Shibahara I、Yamashita Y
- Journal Title
  
  Int J Clin Oncol
  
  Volume: 17巻 Pages: 551-561
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592149
[Journal Article] Clinicopathological analysis of nine consecutive central nervous system primitive neuroectodermal tumors in a single institute2012
- Author(s)
  Aizawa-Kohama M、Yamashita Y
- Journal Title
  
  Brain Tumor Pathol
  
  Volume: 30巻 Pages: 15-27
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592149
[Journal Article] IDH1/2 gene status defines the prognosis and molecular profiles in patients with grade III gliomas.2012
- Author(s)
  Shibahara I, Sonoda Y, Kanamori M, Saito R, Yamashita Y, Kumabe T, Watanabe M, Suzuki H, Kato S, Ishioka C, Tominaga T.
- Journal Title
  
  Int J Clin Oncol
  
  Volume: 17(6) Pages: 551-61
- NAID
  10031155913
- Data Source
  KAKENHI-PROJECT-22590298
[Journal Article] Novel function of MKP-5/DUSP10, a phosphatase for stress-activated kinases, on ERK dependent gene expression, and up-regulation of its gene expression in colon carcinomas2012
- Author(s)
  Nomura M、Yamashita Y、Shima H
- Journal Title
  
  Oncol Rep
  
  Volume: 28巻 Pages: 931-936
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592149
[Journal Article] Safety and feasibility of convection-enhanced delivery of nimustine hydrochloride co-infused with free gadolinium for real-time monitoring in the primate brain2012
- Author(s)
  Sugiyama S、Yamashita Y
- Journal Title
  
  Neurol Res
  
  Volume: 34巻 Pages: 581-587
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592149
[Journal Article] Novel function of MKP-5/DUSP10, a phosphatase for stress-activated kinases, on ERK dependent gene expression,and up-regulation of its gene expression in colon carcinomas2012
- Author(s)
  Nomura M, Shiiba K-I, Katagiri C, Kasugai I, Masuda K, Sato I, Sato M, Kakugawa Y, Nomura E, Hayashi K, Nakamura Y, Nagata T, Otsuka T, KatakuraR, Yamashita Y, Sato M, Tanuma N, Shima H
- Journal Title
  
  Oncol Rep.
  
  Volume: 28(3) Pages: 931-6
- Data Source
  KAKENHI-PROJECT-22590298
[Journal Article] DUSP13B/TMDP inhibits stress-activated MAPKs and suppresses AP-1-dependent gene expression2011
- Author(s)
  Yoji Yamashita,Nobuhiro Tanuma
- Journal Title
  
  Molecular and Cellular Biochemistry
  
  Volume: 352 Pages: 155-162
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592149
[Journal Article] DUSP13B/TMDPinhibits stress-activated MAPKs and suppresses AP-1-dependent gene expression2011
- Author(s)
  Katagiri C, Masuda K, Nomura M, Tanoue K, Fujita S, Yamashita Y, Katakura R, Shiiba K, Nomura E, Sato M, Tanuma N, Shima H
- Journal Title
  
  Molecular and Cellular Biochemistry
  
  Volume: 352(1-2) Pages: 155-162
- Data Source
  KAKENHI-PROJECT-22590298
[Journal Article] CDC25A mRNA levels significantly correlate with Ki-67 expression in human glioma samples.2010
- Author(s)
  Yoji Yamashita
- Journal Title
  
  Journal of Neuro-Oncology
  
  Volume: 100 Pages: 43-49
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590298
[Journal Article] O(6)-Methylguanine DNA methyltransferase determined by promoter hypermethylation and immunohistochemical expression is correlated with progression-free survival in patients with glioblastoma.2010
- Author(s)
  Sonoda Y, Yokosawa M, Saito R, Kanamori M, Yamashita Y, Kumabe T, Watanabe M, Tominaga T.
- Journal Title
  
  Int J Clin Oncol.
  
  Volume: 4 Pages: 352-358
- NAID
  10026601301
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390378
[Journal Article] CDC25A mRNA levels significantly correlate with Ki-67 expression in human glioma samples.2010
- Author(s)
  Yamashita Y, Kasugai I, Sato M, Tanuma N, Sato I, Nomura M, Yamashita K, Sonoda Y, Kumabe T, Tominaga T, Katakura R, Shima H
- Journal Title
  
  J Neurooncol 100
  
  Pages: 43-49
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591730
[Journal Article] O(6)-Methylguanine DNA methyltransferase determined by promoter hypermethylation and immunohistochemical expression is correlated with progression-free survival in patients with glioblastoma.2010
- Author(s)
  Sonoda Y, Yokosawa M, Saito R, Kanamori M, Yamashita Y, Kumabe T, Watanabe M, Tominaga T.
- Journal Title
  
  Int J Clin Oncol. 4
  
  Pages: 352-358
- NAID
  10026601301
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390378
[Journal Article] CDC25A mRNA levels significantly c orrelate with Ki-67 expression in human glioma samples2010
- Author(s)
  Yamashita Y, Kasugai I, Sato M, Tanuma N, Sato I, Nomura M, Yamashita K,Sonoda Y, Kumabe T, Tominaga T, Katakura R, Shima H
- Journal Title
  
  Journal of Neuro-Oncology
  
  Volume: 100(1) Pages: 43-49
- Data Source
  KAKENHI-PROJECT-22590298
[Journal Article] CDC25A mRNA levels significantly correlate with Ki-67 expression in human glioma samples2010
- Author(s)
  Yamashita Y
- Journal Title
  
  J Neurooncol
  
  Volume: 100 Pages: 43-49
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591730
[Journal Article] Convection-enhanced delivery of a synthetic retinoid Am80, loaded into polymeric micelles, prolongs the survival of rats bearing intracranial glioblastoma xenografts.2010
- Author(s)
  Yokosawa M, Sonoda Y, Sugiyama S, Saito R, Yamashita Y, Nishihara M, Satoh T, Kumabe T, Yokoyama M, Tominaga T
- Journal Title
  
  Tohoku J Exp Med 221
  
  Pages: 257-264
- NAID
  10027085245
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591730
[Journal Article] Therapeutic efficacy of a polymeric micellar doxorubicin infused by convection-enhanced delivery against intracranial 9L brain tumor models2009
- Author(s)
  T.Inoue, Y.Yamashita, M.Nishihara, S.Sugiyama, Y.Sonoda, T.Kumabe, M.Yokoyama, T.Tominaga
- Journal Title
  
  Neuro-Oncology 11
  
  Pages: 151-157
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20015049
[Journal Article] Protein phosphatase Dusp26 associates with KIF3 motor and promotes N-cadherin-mediated cell-cell adhesion.2009
- Author(s)
  Tanuma N, Nomura M, Ikeda M, Kasugai I, Tsubaki Y, Takagaki K, Kawamura T, Yamashita Y, Sato I, Sato M, Katakura R, Kikuchi K, Shima H
- Journal Title
  
  Oncogene 28
  
  Pages: 752-761
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591730
[Journal Article] Enhanced in vivo antitumor efficacy of fenretinide encapsulated in polymeric micelles2009
- Author(s)
  Tomoyuki Okuda, Shigeru Kawakami, Yuriko Higuchi, Taku Satoh, Yoshimi Oka, Masayuki Yokoyama, Fumiyoshi Yamashita, Mitsuru Hashida
- Journal Title
  
  International Journal of Pharmaceutics 373
  
  Pages: 100-106
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20015049
[Journal Article] Therapeutic efficacy of a polymeric micellar doxorubicin infused by convection-enhanced delivery against intracranial 9L brain tumor models.2009
- Author(s)
  Inoue T, Yamashita Y, Nishihara M, Sugiyama S, Sonoda Y, Kumabe T, Yokoyama M, Tominaga T
- Journal Title
  
  Neuro Oncol 11
  
  Pages: 151-157
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591730
[Journal Article] Therapeutic efficacy of a polymeric micellar doxorubicin infused by convection-enhanced dilivery against intracranial 9L brain tumor models
- Author(s)
  T. Inoue, Y. Yamashita, M. Nishihara, S. Sugiyama, Y. Sonoda, T. Kumabe, M. Yokoyama, T. Tominaga
- Journal Title
  
  Neuro-Oncology (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20015049
[Presentation] Ppp6c は、マウス皮膚のがん抑制遺伝子として働く2017
- Author(s)
  黒沢是之、野村美有樹、角川陽一郎、山下洋二、三浦康、山田秀和、松浦一登、佐藤郁郎、田沼延公、渡邊利雄、島礼
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16K10774
[Presentation] Pyruvate kinase Mの両isoformを欠損するマウスの解析2016
- Author(s)
  田中遼太、小河穂波、井上維、山下洋二、三浦康、河合賢郎、佐藤郁郎、渡邊利雄、島礼、田沼延公
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  宮城県・仙台市
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-16K10774
[Presentation] PKMノックアウトマウスは胎生致死となる2016
- Author(s)
  田中遼太、渡邊利雄、山下洋二、三浦康、佐藤郁郎、島礼、田沼延公
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  神奈川県・横浜市
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-26430130
[Presentation] Pyruvate kinase Mの両isoformを欠損するマウスの解析2016
- Author(s)
  田中遼太、小河穂波、井上維、山下洋二、三浦康、河合賢郎、佐藤郁郎、渡邊利雄、島礼、田沼延公
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  宮城県・仙台市
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-26430130
[Presentation] 新規皮膚がん抑制遺伝子Ppp6c変異は、変異型K-RASによる腫瘍発生を強く促進する2016
- Author(s)
  黒沢是之、田沼延公、角川陽一郎、山下洋二、三浦康、山田秀和、佐藤郁郎、野村美有樹、渡利雄、島礼
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  神奈川県・横浜市
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-16K10774
[Presentation] PKMノックアウトマウスは胎生致死となる2016
- Author(s)
  田中遼太、渡邊利雄、山下洋二、三浦康、佐藤郁郎、島礼、田沼延公
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  神奈川県・横浜市
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-16K10774
[Presentation] 75歳を超える高齢悪性神経膠腫患者の治療2016
- Author(s)
  山下洋二、冨永悌二、片倉隆一
- Organizer
  第34回日本脳腫瘍学会学術集会
- Place of Presentation
  山梨県・甲府市
- Data Source
  KAKENHI-PROJECT-16K10774
[Presentation] 80歳を超える高齢悪性神経膠腫患者の治療2016
- Author(s)
  山下洋二、冨永悌二、片倉隆一
- Organizer
  日本脳神経外科学会　第75回学術総会
- Place of Presentation
  福岡県・福岡市
- Data Source
  KAKENHI-PROJECT-16K10774
[Presentation] 新規皮膚がん抑制遺伝子Ppp6c変異は、変異型K-RASによる腫瘍発生を強く促進する2016
- Author(s)
  黒沢是之、田沼延公、角川陽一郎、山下洋二、三浦康、山田秀和、佐藤郁郎、野村美有樹、渡利雄、島礼
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  神奈川県・横浜市
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-26430130
[Presentation] 皮膚Ppp6c欠損マウスは、UVB誘導皮膚扁平上皮発がんに高感受性となる2015
- Author(s)
  加藤浩之、田沼延公、三浦康、角川陽一郎、椎葉健一、山下洋二、林克剛、野村美有樹、佐藤郁郎、伊藤しげみ、渡邊利雄、島礼
- Organizer
  第74回　日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場(愛知県・名古屋市）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-26430130
[Presentation] ノックインモデルを用いた、ピルビン酸キナーゼM（PKM）アイソフォームの機能解析2013
- Author(s)
  坂本良美、渡邊利雄、野村美有樹、山下洋二、椎葉健一、佐藤郁郎、佐藤雅美、島礼、田沼延公
- Organizer
  第72回日本癌学会学術集会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23592149
[Presentation] ノックインモデルを用いた、ピルビン酸キナーゼM(PKM)アイソフォームの機能解析2013
- Author(s)
  坂本良美、渡邊利雄、野村美有樹、山下洋二、椎葉健一、佐藤郁郎、佐藤雅美、島礼、田沼延公
- Organizer
  第72回日本癌学会学術集会
- Place of Presentation
  横浜
- Year and Date
  2013-10-05
- Data Source
  KAKENHI-PROJECT-23592149
[Presentation] Generation of knock-in mice to dissect isoform-specific roles for each splicing isoform of pyruvate kinase M in vivo2013
- Author(s)
  松本祥子、坂本良美、野村美有樹、田中遼大、盛田麻美、伊藤しげみ、椎葉健一、野村栄樹、片倉隆一、山下洋二、佐藤郁郎、渡邊利雄、島礼、田沼延公
- Organizer
  第36回分子生物学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-24501326
[Presentation] Ptprz gene encoding a transmembrene-type protein phosphatase is up-regulated by Sox-2 in glioma.2013
- Author(s)
  Yoji Yamashita,Nobuhiro Tanuma,Ichiro Shibahara,Yukihiro Sonoda,Masayuki Kanamori,Ryuta Saito,Toshihiro Kumabe,Teiji Tominaga,Hiroshi Shima,Ryuichi Katakura
- Organizer
  AACR ANNUAL MEETING 2013
- Place of Presentation
  Washington,DC
- Data Source
  KAKENHI-PROJECT-23592149
[Presentation] Generation of knock-in mice to dissect isoform-specific roles for each splicing isoform of pyruvate kinase M in vivo2013
- Author(s)
  松本祥子、坂本良美、野村美有樹、田中遼大、盛田麻美、伊藤しげみ、椎葉健一、野村栄樹、片倉隆一、山下洋二、佐藤郁郎、渡邊利雄、島礼、田沼延公
- Organizer
  第36回分子生物学会
- Place of Presentation
  神戸
- Year and Date
  2013-12-05
- Data Source
  KAKENHI-PROJECT-23592149
[Presentation] ノックインモデルを用いた、ピルビン酸キナーゼM（PKM）アイソフォームの機能解析2013
- Author(s)
  坂本良美、渡邊利雄、野村美有樹、山下洋二、椎葉健一、佐藤郁郎、佐藤雅美、島礼、田沼延公
- Organizer
  第72回日本癌学会学術集会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24501326
[Presentation] Ptprz gene encoding a transmembrene-type protein phosphatase is up-regulated by Sox-2 in glioma2013
- Author(s)
  Yoji Yamashita, Nobuhiro Tanuma, Ichiro Shibahara, Yukihiro Sonoda, Masayuki Kanamori,Ryuta Saito, Toshihiro Kumabe, Teiji Tominaga, Hiroshi Shima, Ryuichi Katakura
- Organizer
  AACR ANNUAL MEETING 2013
- Place of Presentation
  Washington,DC
- Year and Date
  2013-04-06
- Data Source
  KAKENHI-PROJECT-23592149
[Presentation] A mouse model incapable of switching PKM isoforms2012
- Author(s)
  田沼延公、山下洋二、島礼、渡邊利雄
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Year and Date
  2012-09-20
- Data Source
  KAKENHI-PROJECT-23592149
[Presentation] PKMスイッチ不可能なマウスモデル2012
- Author(s)
  田沼延公、渡邊利雄、野村美有樹、佐藤郁郎、椎葉健一、山下洋二、佐藤雅美、島礼
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-22590298
[Presentation] 悪性グリオーマ検体およびグリオーマ樹立株におけるPTPzetaの解析2012
- Author(s)
  山下洋二、春日井勲、田沼延公、柴原一陽、園田順彦、金森政之、齋藤竜太、隅部俊宏、冨永悌二、島礼、片倉隆一
- Organizer
  脳神経外科学会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-22590298
[Presentation] Phospho-Regulation of Splicesomal Protein, Sap155/Sf3b12011
- Author(s)
  Tanuma N, Nomura M, Sato M, Yamashita Y, Shiiba K, Katakura K, and ShimaH
- Organizer
  9th International Conference on Protein Phosphatase & Ist International Symposium on Carcinogenic Spiral
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PROJECT-22590298
[Presentation] 「グリオーマにおけるピルビン酸キナーゼＭ（ＰＫＭ）スプライシングのスイッチ機構」2011
- Author(s)
  山下洋二,島礼
- Organizer
  日本脳神経外科学会　第70回学術総会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-23592149
[Presentation] Generation of isoform-specific antibodies against pyruvate kinase (PKM)2010
- Author(s)
  野村美有樹、田沼延公、山下洋二、椎葉健一、角川陽一郎、佐藤郁郎、島礼
- Organizer
  第69回日本癌学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22590298
[Presentation] グリオーマにおけるピルビン酸キナーゼM(PKM)のスプライシング異常2010
- Author(s)
  山下洋二
- Organizer
  第28回日本脳腫瘍学会学術集会
- Place of Presentation
  長野県北佐久郡軽井沢町
- Data Source
  KAKENHI-PROJECT-20591730
[Presentation] グリオーマにおけるピルビン酸キナーゼM(PKM)のスプライシング異常2010
- Author(s)
  山下洋二
- Organizer
  日本脳神経外科学会第69回学術総会
- Place of Presentation
  福岡県福岡市
- Data Source
  KAKENHI-PROJECT-20591730
[Presentation] Aberrant pre-mRNA splicing of pyrubate kinase M (PKM) in human cancer2010
- Author(s)
  田沼延公、野村美有樹、山下洋二、椎葉健一、角川陽一郎、佐藤郁郎、島礼
- Organizer
  第69回日本癌学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22590298
[Presentation] CDC25A mRNA levels significantly correlate with Ki-67 expression in human glioma samples.2010
- Author(s)
  Yamashita Y
- Organizer
  7^<th>Meeting of Asian Society for Neuro-Oncology
- Place of Presentation
  Seoul (Korea)
- Data Source
  KAKENHI-PROJECT-20591730
[Presentation] CDC25A mRNA levels significantly correlate with Ki-67 expression in human glioma samples2010
- Author(s)
  Yamashita Y
- Organizer
  第11回日本分子脳神経外科学
- Place of Presentation
  Seoul, Korea
- Data Source
  KAKENHI-PROJECT-20591730
[Presentation] グリオーマにおける解糖系酵素遺伝子のスプライシング異常2010
- Author(s)
  山下洋二
- Organizer
  第11回日本分子脳神経外科学
- Place of Presentation
  宮城県仙台市
- Data Source
  KAKENHI-PROJECT-20591730
[Presentation] 神経膠腫検体および神経膠腫樹立細胞株を用いたCDC25Aの解析2009
- Author(s)
  山下洋二
- Organizer
  第27回日本臆腫瘍学会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20591730
[Presentation] 神経膠腫検体および神経膠腫樹立細胞株を用いたCDC25Aの解析2009
- Author(s)
  山下洋二
- Organizer
  第27回日本脳腫瘍学会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20591730
[Presentation] Analysis of CDC25 genes in malignant glioma samples2009
- Author(s)
  山下洋二
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  神奈川
- Data Source
  KAKENHI-PROJECT-20591730
[Presentation] 神経膠腫検体および神経膠腫樹立細胞株を用いたCDC25Aの解析2009
- Author(s)
  山下洋二
- Organizer
  第10回日本分子脳神経外科学会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-20591730
[Presentation] Analysis of CDC25 genes in malignant glioma samples.2009
- Author(s)
  山下洋二
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-20591730
[Presentation] 神経膠腫検体および神経膠腫樹立細胞株を用いたCDC25Aの解析2009
- Author(s)
  山下洋二
- Organizer
  第10回日本分子脳神経外科学
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-20591730
[Presentation] 神経膠腫検体および神経膠腫樹立細胞株を用いたCDC25Aの解析2009
- Author(s)
  山下洋二
- Organizer
  (財)日本脳神経外科学会第68回学術総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20591730
[Presentation] 高分子ミセル抗癌剤の convection-enhanced delivery 法への応用2008
- Author(s)
  山下洋二
- Organizer
  第24回日本DDS学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20591730
[Presentation] 高分子ミセル抗癌剤のconvection-enhanced delivery法への応用2008
- Author(s)
  山下洋二
- Organizer
  第24回日本DDS学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20591730
[Presentation] 正常カニクイザル脳内にconvection-enhanced delivery法により投与されたガドリニウムミセルのMRIによるりアルタイムモニタリング2008
- Author(s)
  山下洋二
- Organizer
  第67回日本脳神経外科学会
- Place of Presentation
  盛岡グランドホテル
- Year and Date
  2008-10-02
- Data Source
  KAKENHI-PROJECT-19659358
[Presentation] Convection-Enhanced Delivery法によるACNU投与と放射線療法あるいはtemozolomide全身投与との併用療法2007
- Author(s)
  山下洋二
- Organizer
  第16回脳神経外科手術と機器学会
- Place of Presentation
  東京
- Year and Date
  2007-04-12
- Data Source
  KAKENHI-PROJECT-18791006

1. SHIMA Hiroshi (10196462)

# of Collaborated Projects: 6 results

# of Collaborated Products: 30 results
2. TANUMA Nobuhiro (40333645)

# of Collaborated Projects: 4 results

# of Collaborated Products: 7 results
3. 佐藤郁郎 (50225918)

# of Collaborated Projects: 3 results

# of Collaborated Products: 10 results
4. YOKOYAMA Masayuki (20220577)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
5. SONODA Yukihiko (90302140)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
6. 金森政之 (60420022)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
7. NOMURA Miyuki (40390893)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. WATANABE Tosio (60201208)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. SUGAMURA Kazuo (20117360)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. ITO Shigemi (80600006)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. 隈部俊宏 (10250747)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 冨永悌二 (00217548)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 長南雅志 (90813676)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 加藤浩之 (90770347)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. KAWAI Masaaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. FUJII Yukihiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
17. 渡辺利雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
18. 小川欣一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 富永悌二

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
20. 前門戸任

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

YAMASHITA Yoji 山下 洋二

山下 洋二 ヤマシタ ヨウジ

Research Projects

Research Products

Co-Researchers

悪性神経膠腫における鉄関連メタボリズムの役割Principal Investigator

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変異型KRASによる腫瘍化を抑えるがん抑制遺伝子の同定（膵臓がんへの関与）

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A novel molecularly-targeted therapy for IDH-mutant gliomas.Principal Investigator

Principal Investigator

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Identification of a protein phosphatase which involved in brain tumororigenesis.Principal Investigator

Principal Investigator

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Tumor promotion associated with Ppp6c-deficiency.

Principal Investigator

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Roles for pyruvate kinase M in tumorigenesis

Principal Investigator

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Development of a novel therapy by targeting Warburg effect of gliomas.Principal Investigator

Principal Investigator

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Regulation of KIF3 motor by dephosphorylation

Principal Investigator

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CED法と高分子ミセルキャリヤーを用いた新規脳腫瘍化学療法システム

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Review Section

Research Institution

Convection-enhanced delivery of ACNU with systemic administration of temozolomide

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Research Institution

Therapeutic effect of the polymeric micellar antineoplastic drugs infused convection-enhanced delivery against intracranial rat glioma modelsPrincipal Investigator

Principal Investigator

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Research Institution

ドキソルビシン・リポソームの対流強化輸送法への応用

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Research Institution

ドキソルビシンリポソームCED・テモゾロマイド全身投与併用による膠芽腫新規治療法Principal Investigator

Principal Investigator

Project Period (FY)

YAMASHITA Yoji 山下洋二

山下洋二ヤマシタヨウジ