TAIRA Kazunari 多比良和誠

Researcher Number	10261778
Other IDs
Affiliation (based on the past Project Information) *help	2002 – 2006: 東京大学, 工学系研究科, 教授 2000 – 2005: 東京大学, 大学院・工学系研究科, 教授 2004: 東京大学, 大学院・工学研究科, 教授 2000 – 2002: 東京大学, 大学院・工学研究科, 教授 2000: 東京大学, 工学系研究科, 教授 1995 – 1999: 筑波大学, 応用生物化学系, 教授
Review Section/Research Field	Principal Investigator Biological Sciences / 生物・生体工学 Except Principal Investigator Biological Sciences / Molecular biology / Experimental pathology / 応用薬理学・医療系薬学 / Applied genomics / Biological pharmacy
Keywords	Principal Investigator アポトシス / ジーンディスカバリー / RNA干渉 / 遺伝子治療 / RNAiライブラリー / RNA interference / pol III系 / U6プロモーター / がん遺伝子 / polIII系 … More Except Principal Investigator リボザイム / RNA / 遺伝子治療 / 発現制御 / RNAi / ribozyme / siRNA / UT7 / GATA-1 / AML-1 / ETS-1 / USF / HIV-1 / エイズ / ケモカイン / コレセプター / 阻害剤 / アンチセンス / Tat / HIV / V3 loop / Rev / クワシスピーシス / 中和モノクローナル抗体 / 硫酸アルキルオリゴ糖 / エイズ遺伝子治療 / V3loop / アデノウイルスベクター / guttedベクター / 部位特異的組換え酵素 / Cre / loxP / FLP / FRT / 遺伝子置換反応 / ウイルスベクター / アデノウイルス / ウィルスベクター / 遺伝子置換 / アデノウィルス / レトロウイルスベクター / ネットワーク / RNA蛋白質複合体 / 高次複合機能 / 分子擬態 / ポストゲノム / 情報発現 / 翻訳調節 / 遺伝子改変ウサギ / 動脈硬化 / 高脂血症 / 動物モデル / 脂質代謝 / CETP / 実験動物 / 遺伝子改変 / 遺伝子導入 / ノックダウン / グループIイントロン / 分子デザイン / ハンマーヘッド型リボザイム / snRNP / リボソーム / スプライソソーム / ヘアピン型リボザイム / ンマーヘッド型リボザイム / G167 / GNRA-receptor 4 / マキシザイム / U6snRNA / RNase P / 23SリボソームRNA / 酵素 / 分子設計 / 反応機構 / スプライシング / catalyticRNA / catakytic RNA / snRNA / RNP / group I introns / hammerhead ribozyme / splicing / 蛋白キナーゼC / アイソザイム / G蛋白共役型受容体 / ヒスタミンH1受容体 / 受容体脱感作 / 遺伝子発現 / 受容体情報伝達機構 / ヒスタミンH_1受容体 / 受容体アップ調節 / cGMP依存性蛋白キナーゼ / アップレギュレーション / protein kinase C / isozyme / G protein-coupled receptor / histamine H1 receptor / receptor desensitization / gene expression / signal transduction / 遺伝子 / 核酸 / たんぱく質 / 蛋白質 / gene / nucleic acid / gene expression control / protein / 牛海綿状脳症 / プリオン遺伝子 / RNA干渉作用 / プリオン蛋白 / クローン動物 / クローン動勅 / bovine spongiform encephalopathy / prion gene / RNA interference / prion protein / cloned animal / 巨核球 / 血小板第4因子 / 家族性血小板減少症 / GM細胞 / 免疫沈降 / p21 / E-box / クロマチン免疫沈降 / ドミナントネガティブ / Megakaryocyte / Platelet Factor 4 / FPD / AML / GM cell Less

RNA干渉の開発とがん治療への応用Principal Investigator
- Principal Investigator
  
  多比良和誠
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
RNAiによるノックダウンウサギ・モデルの開発および動脈硬化研究への応用
- Principal Investigator
  
  範江林
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Experimental pathology
- Research Institution
  University of Tsukuba
Production of prion gene-knockdown cattle by RNA interference(RNAi)technology
- Principal Investigator
  
  OTOI Takeshige
- Project Period (FY)
  2004 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied genomics
- Research Institution
  Yamaguchi University
Analyses of transcription factors related to megakaryocyte differentiation and maturation.
- Principal Investigator
  
  DOI Takefumi
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Osaka University
Pol III発現系を用いた哺乳動物細胞におけるRNA干渉の開発とがん治療への応用Principal Investigator
- Principal Investigator
  
  多比良和誠
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Diversity and control of RNA export
- Principal Investigator
  
  OHNO Mutsuhito
- Project Period (FY)
  2002 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
がん治療をめざしたアデノウイルスベクターを用いた発現制御法の開発
- Principal Investigator
  
  斎藤泉
- Project Period (FY)
  2000 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
RNA研究の21世紀への展開
- Principal Investigator
  
  中村義一
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Molecular biology
- Research Institution
  The University of Tokyo
Development of functional analysis of genes in cells using functional nucleic acidsPrincipal Investigator
- Principal Investigator
  
  TAIRA Kazunari
- Project Period (FY)
  2000 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  生物・生体工学
- Research Institution
  University of Tokyo
Regulation of histamine H1 receptor functions by ribozyme-induced isozyme-specific suppression
- Principal Investigator
  
  FUKUI Hiroyuki
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  The University of Tokushima
エイズの病態と制御に関する基礎研究柱5.感染と病態の制御
- Principal Investigator
  
  山本直樹
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Medical and Dental University
Researches on ribozymes at molecular and atomic level
- Principal Investigator
  
  INOUE Tan
- Project Period (FY)
  1997 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Kyoto University

All 2005 2004

All Journal Article Book

[Book] Non-viral Gene Therapy : Gene Design and Delivery(Design of intracellularly active ribozymes and siRNAs.)(Taira, K., Kataoka, K., Niidome, T. Eds.)2005
- Author(s)
  Miyagishi, M., Taira, K.
- Publisher
  Springer-Verlag Tokyo
- Data Source
  KAKENHI-PROJECT-17016018
[Journal Article] A20 is a negative regulator of IFN regulatory factor 3 signaling.2005
- Author(s)
  Saitoh, T., Yamamoto, M., Miyagishi, M., Taira, K., Nakanishi, M., Fujita, T., Akira, S., Yamamoto, N., Yamaoka, S.
- Journal Title
  
  Journal of Immunology 174
  
  Pages: 1507-1512
- Data Source
  KAKENHI-PROJECT-17016018
[Journal Article] Gene therapy for human small-cell lung carcinoma by inactlvaiion of Skp-2 with virally mediated RNA interference.2005
- Author(s)
  Sumimoto, H., Yamagata, S., Shimizu, A., Miyoshi, H., Mizuguchi, H., Hayakawa, T., Miyagishi, M., Taira, K, Kawakami, Y.
- Journal Title
  
  Gene Ther. 12
  
  Pages: 95-100
- Data Source
  KAKENHI-PROJECT-17016018
[Journal Article] Gene discovery by ribozyme siRNA libraries.2005
- Author(s)
  Akashi, H., Matsumoto, S., Taira, K.
- Journal Title
  
  Nature Rev.Mol.Cell.Biol. 6
  
  Pages: 413-422
- Data Source
  KAKENHI-PROJECT-17016018
[Journal Article] siRNA becomes smart intelligent.2005
- Author(s)
  Miyagishi, M., Taira, K.
- Journal Title
  
  Nature Biotech. 23
  
  Pages: 946-947
- Data Source
  KAKENHI-PROJECT-17016018
[Journal Article] Analysis of doubule-stranded RNA-induced apoptosis pathways using interferon-response noninducible small interfering RNA expression vector library.2005
- Author(s)
  Matsumoto, S., Miyagishi, M, Akashi, H., Nagai, R., Taira, K.
- Journal Title
  
  J.Biol.Chem. 282
  
  Pages: 25687-25696
- Data Source
  KAKENHI-PROJECT-17016018
[Journal Article] Identification of a network involved in thapsigargin-induced apoptosis using a library of siRNA-expression vectors.2005
- Author(s)
  Futami, T., M Miyagishi, M., Taira, K.
- Journal Title
  
  J.Biol.Chem. 280
  
  Pages: 826-831
- Data Source
  KAKENHI-PROJECT-17016018
[Journal Article] Genome-wide application of RNAi to the discovery of potential drug targets.2005
- Author(s)
  Ito, M., Kawano, K., Miyagishi, M., Taira, K.
- Journal Title
  
  Gene Ther. 12
  
  Pages: 95-100
- Data Source
  KAKENHI-PROJECT-17016018
[Journal Article] Optimization of an siRNA-expression system with an improved hairpin and its significant suppressive effects in mammalian cells.2004
- Author(s)
  Miyagishi, M., Sumimoto, H., Miyoshi, H., Kawakami, Y., Taira, K.
- Journal Title
  
  Journal of Gene Medicine 6
  
  Pages: 715-723
- Data Source
  KAKENHI-PROJECT-14030011
[Journal Article] A20 is a negative regulator of interferon regulatory factor 3 signaling.2004
- Author(s)
  Saitoh, T., Yamamoto, M., Miyagishi, M., Taira, K., Nakanishi, M., Fujita, T., kira, S., Yamamoto, N., Yamaoka, S.
- Journal Title
  
  Journal of Immunology 174
  
  Pages: 1507-1512
- Data Source
  KAKENHI-PROJECT-14030011
[Journal Article] Know-how of RNA interference and its applications in research and therapy.2004
- Author(s)
  Wadhwa, R., Kaul, S.C., Miyagishi, M., Taira, K.
- Journal Title
  
  Mutat.Res. 567
  
  Pages: 71-84
- Data Source
  KAKENHI-PROJECT-14030011
[Journal Article] Identification of a network involved in thapsigargin-induced apoptosis using a library of siRNA-expression vectors.2004
- Author(s)
  Futami, T., Miyagishi, M., Taira, K.
- Journal Title
  
  J.Biol.Chem. 280
  
  Pages: 826-831
- Data Source
  KAKENHI-PROJECT-14030011
[Journal Article] Use of a randomized hybrid ribozyme library for identification of genes involved in muscle differentiation.2004
- Author(s)
  Wadhwa, R., Yaguchi, T., Kaur, K., Suyama, E., Kawasaki, H., Taira, K., Kaul, S.C.
- Journal Title
  
  J.Biol.Chem. 279
  
  Pages: 51622-51629
- Data Source
  KAKENHI-PROJECT-14030011
[Journal Article] Identification of metastasis-related genes using a library of randomized ribozymes in a mouse model.2004
- Author(s)
  Suyama, E., Wadhwa, R., Kaur, K., Miyagishi, M., Kaul, S.C., Kawasaki, H., Taira, K.
- Journal Title
  
  J.Biol.Chem. 279
  
  Pages: 38083-38086
- Data Source
  KAKENHI-PROJECT-14030011

1. MIYAGISHI Makoto (30323538)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
2. INOUE Tan (40114855)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. SHIRAISHI Hideaki (90202118)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. TANI Tokio (80197516)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. SAKAMOTO Kensaku (50240685)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. SUZUKI Tsutomu (20292782)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. KAWASAKI Hiroaki (60332623)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. KURATA Hiroyuki (90251371)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. AWAI Shigenori (10168544)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. FUKUI Hiroyuki (90112052)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. OHNO Mutsuhito (80201979)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. OTOI Takeshige (30311814)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. YAMANOTO Yoshimi (40115514)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. SUTOU Shizuyo (80368696)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. DOI Takefumi (00211409)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. NAKANO Tohru (00172370)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 山本直樹 (00094053)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 島田隆 (20125074)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 伊藤正彦 (90045740)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 松下修三 (00199788)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 志田壽利 (00144395)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 高久洋 (50101267)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 斎藤泉 (70158913)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 鐘ヶ江裕美 (80251453)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 小澤敬也 (30137707)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 伊庭英夫 (60111449)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 中村義一 (40114590)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. 横山茂之 (00159229)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. 渡辺公綱 (00134502)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. 志村令郎 (60025426)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. 饗場弘二 (20025662)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. 範江林 (60272192)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. 孫慧君 (00361329)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
34. 小松康雄 (30271670)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
35. 新田至 (30272404)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

TAIRA Kazunari 多比良 和誠

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Co-Researchers

RNA干渉の開発とがん治療への応用Principal Investigator

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Pol III発現系を用いた哺乳動物細胞におけるRNA干渉の開発とがん治療への応用Principal Investigator

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Development of functional analysis of genes in cells using functional nucleic acidsPrincipal Investigator

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[Book] Non-viral Gene Therapy : Gene Design and Delivery(Design of intracellularly active ribozymes and siRNAs.)(Taira, K., Kataoka, K., Niidome, T. Eds.)2005

Author(s)

Publisher

Data Source

[Journal Article] A20 is a negative regulator of IFN regulatory factor 3 signaling.2005

Author(s)

Journal Title

Data Source

[Journal Article] Gene therapy for human small-cell lung carcinoma by inactlvaiion of Skp-2 with virally mediated RNA interference.2005

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Data Source

[Journal Article] Gene discovery by ribozyme siRNA libraries.2005

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Journal Title

TAIRA Kazunari 多比良和誠