Yamada Mitsuhiko 山田充彦

… Alternative Names

山田充彦ヤマダミツヒコ

YAMADA Mitsuhiko 山田充彦

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Researcher Number	10263237
Other IDs
External Links
Affiliation (Current)	2025: 信州大学, 医学部, 特任教授
Affiliation (based on the past Project Information) *help	2023: 信州大学, 学術研究院医学系, 教授 2014 – 2020: 信州大学, 学術研究院医学系, 教授 2013: 信州大学, 医学部, 教授 2009 – 2011: Shinshu University, 医学部, 教授 2004 – 2006: 信州大学, 医学部, 教授 … More 2002 – 2003: Osaka University Graduate School of Medicine, Department of Pharmacology II, Associate Professor, 医学系研究科, 助教授 2002: 大阪大学, 大学院・医学研究科・情報薬理学講座, 助教授 2000 – 2001: 国立循環器病センター研究所, 心臓生理部, 室長 1998: Osaka University, Faculty of Medicine, Assistant Professor 1998: 国立循環器病センター研究所, 心臓生理部, 室長 1994 – 1998: 大阪大学, 医学部, 助手 1995: 大阪大学, 医学部・, 助手 Less
Review Section/Research Field	Principal Investigator Basic Section 48020:Physiology-related / General pharmacology / Circulatory organs internal medicine / 応用薬理学・医療系薬学 Except Principal Investigator General pharmacology / Circulatory organs internal medicine / General physiology / Cardiovascular medicine / Anesthesiology / Thoracic surgery / Pathological medical chemistry / Orthopaedic surgery
Keywords	Principal Investigator 心筋細胞 / Kir6.2 / 心臓 / Kir2.2 / IRK2 / アロステリックモデル / パッチクランプ / K^+チャネル開口薬 / ATP感受性K^+チャネル / ポリアミン … More / 内向き整流カリウムチャネル / 発達生理学 / 細胞内情報伝達機構 / AT１受容体 / アンジオテンシンII / 発達薬理学 / バイアス信号 / G蛋白質 / I型アンジオテンシンII受容体 / レニン・アンジオテンシン系 / ホルモン / 増殖因子 / サイトカイン / L型Ca2+チャネル / 周産期 / 最終分化 / 分裂刺激因子 / 最終分化因子 / 小児がん / 腫瘍心臓病学 / gp130 / インターロイキン6 / 分化 / 細胞分裂 / 新生児 / K^+ channel openers / allosteric model / nucleotides / nucleotide-binding domains / ABC proteins / sulfonylurea receptors / ATP-sensitive K^+ channels / 平滑筋 / クレアチンキナーゼ / ヌクレオチド / ヌクレオチド結合ドメイン / ABC蛋白質 / スルフォニルウレア受容体 / Adenylate Cyclase / Muscarinic K channel / Tertiapin / Muscarinic receptor / Negative chronotropic effect / Sinoatrial node / Heart / Parasympathetic nerve / 副交感性心拍調節 / スローブロック / 過分極誘発性非特異的カチオン電流 / 洞性徐脈 / 心電図 / ムスカリン性受容体刺激 / βアドレナリン性受容体刺激 / アデニル酸シクラーゼ / ムスカリン性Kチャネル / テルティアピン / ムスカリン性受容体 / 陰性変時作用 / 洞房結節 / 副交感神経 / I_<K1> channel / Polyamine / Mg2+ / Inwardly-rectifying K^+ channel / 拮抗剤 / I_<KI>チャネル / I_<K1>チャネル / Mg^<2+> / 内向き整流K^+チャネル / 不活性化 / Ca_v1.2 / L型カルシウムチャネル / Timothy症候群 / 膜電位依存性不活性化 / ジヒドロピリジン / Ca_V<1. 2> L型カルシウムチャネル / Kir6.1 / スルフォニルユレア受容体 / 血管平滑筋 / 分子生物学 / マグネシウム … More Except Principal Investigator カリウムチャネル / G蛋白質 / 内向き整流性カリウムチャネル / ATP / 膜2回貫通型カリウムチャネル / 中枢神経系 / クラスター / 中枢神経 / パッチクランプ / カリウム / クローニング / 心臓 / ATP感受性カリウムチャネル / グリア細胞 / G蛋白 / パッチクランプ法 / 分子生物学 / 内向き整流カリウムチャネル / FRET / inward rectifier / ラミニン / ミュラー細胞 / 網膜 / スルフォニルユレア受容体 / 内向き整流K^+チャネル / スルホニルウレア受容体 / アンカリング蛋白 / ポリアミン / sulfonylurea receptor / cloning / チャネル / 培養細胞 / L型カルシウムチャネル / 骨格筋 / 分子心臓病学 / 循環器 / シグナル経路 / エピジェネティクス / 転写制御 / シグナル伝達経路 / エピゲノム / 転写因子 / 遺伝子 / 心不全 / 分子心臓学 / 新規鎮痛薬 / Nav1.7阻害薬 / ミスセンス / Nav1.7 / ナトリウムチャネル / ウインドウカレント / ノックインマウス / 変異 / ramp電流 / 遺伝子変異 / バイオインフォマティクス / 創薬 / 1塩基変異 / ナトリウムチャネル1.7 / 無痛症 / Lipid raft / Calmodulin / PDZ protein / RGS protein / G protein-gated potassium channel / カルモデュリン / カルモディリン / G蛋白質制御カリウムチャネル / 蛍光エネルギー共鳴移動法 / 脂質ラフト / カルモジュリン / PDZ蛋白質 / RGS蛋白質 / G蛋白制御カリウムチャネル / contrast echocardiography / end-stage heart failure / arrhythmia / granulocyte-colony stimulating factor / paracrine mechanism / bone marrow cell / cell transplantation therapy / 心筋梗塞 / ドキソルビシン / 環境因子 / 分化 / 心筋細胞 / 再生 / 心筋症 / 再生医療 / コントラストエコー / 重症心不全 / 不整脈 / 顆粒球コロニー刺激因子 / paracrine作用 / 骨髄細胞 / 細胞療法 / sulfonylurea / K channel opener / ion channel / 血管平滑筋 / カリウムチャネル開口薬 / カリウムチャネル開口剤 / スルホニルウレア / 膵臓 / カリウムチャネルの開口剤 / neuron / substantia nigra / pituitary / hormone secretion / dopaminergic neuron / G protein / ion chanel / インスリン / G蛋白調整性カリウムチャネル / patch clamp / chromosome / water channel / parietal cell / stomach / glia / potassium channel / SAP97 / clustering / RT-PCR / spatial buffering / クラスタリング / 染色体地図 / 壁細胞 / 水チャネル / Hormone / Central Nervous System / Sulffonylurea receptor / Anchering protein / G-protein regulated K+channel / ATP sensitive K+channel / 2 membrane spanning K+channel / Inwardly rectifying K+channel / _CGMP / _CAMP / アンカリング蛋白質 / G蛋白質調節性K^+チャネル / ATP感受性K^+チャネル / 膜2回貫通型K^+チャネル / アクアポリン / ホルモン / G蛋白調節性カリウムチャネル / cluster / polyamine / GTP-binding protein / synaps / knockout / brain / K^+ channels / シナプス / ノックアウト / culture cell / K^+ channel opener / smooth muscle / heart / ATP-sensitive potassium channels / NDP / K_<ATP>チャネル / cDNA / スルフォニルウレア / ATP感受性チャネル / スルフオニル尿素受容体 / カリウムチャネルオープナ- / スルフォニル尿素受容体 / 平滑筋 / L型Ca2+チャネル / 筋委縮 / 除神経 / 加齢 / サルコペニア / 結合膜構造 / リアノジン受容体 / ジャンクトフィリン / Ｌ型カルシウムチャネル / アフリカツメガエル卵母細胞 / 点変異導入クローン / キメラクローン / トランスフェクション / HEK293細胞 / ATP依存性カリウムチャネル / サイクリックGMP / スライスパッチ / 内向き整流特性カリウム Less

Analyses of the molecular mechanism underlying and the functional significance of developmental changes in intracellular signal transduction systems coupled to cardiac AT1 receptors.Principal Investigator
- Principal Investigator
  
  山田充彦
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48020:Physiology-related
- Research Institution
  Shinshu University
Identification of factors promoting final differentiation of cardiac myocytes after birthPrincipal Investigator
- Principal Investigator
  
  yamada mitsuhiko
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48020:Physiology-related
- Research Institution
  Shinshu University
Discovery of novel Nav1.7 inhibitors by using bioinformatics
- Principal Investigator
  
  Kawamata Mikito
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Anesthesiology
- Research Institution
  Shinshu University
Elucidation of epigenetic regulation of gene expresson involved in maintaining cardiac function and metabolism
- Principal Investigator
  
  KUWAHARA Koichiro
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Shinshu University
  Kyoto University
Changes in expression of L-type calcium channel subunits in skeletal muscle with aging.
- Principal Investigator
  
  KATO Hiroyuki
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Shinshu University
Localization and function of L-type calcium channels in skeletal muscle is regulated by junctophilins.
- Principal Investigator
  
  NAKADA Tsutomu
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Shinshu University
Quantitative analysis of the open-state affinity of L-type calcium channel blockers and modeling of their inhibitory actionsPrincipal Investigator
- Principal Investigator
  
  YAMADA Mitsuhiko
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Shinshu University
Analysis of the molecular mechanism underlying the regulation of ATP-sensitive K+ channels by drugsPrincipal Investigator
- Principal Investigator
  
  YAMADA Mitsuhiko
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Shinshu University
Molecular mechanisms for functional and spatial regulation of the G protein-gated potassium channel
- Principal Investigator
  
  KURACHI Yoshihisa
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  General physiology
- Research Institution
  Osaka University
Regeneration of myocardium using bone marrow cells for the treatment of severe heart failure
- Principal Investigator
  
  SUGA Michiharu, 富田伸司
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Thoracic surgery
- Research Institution
  National Cardiovascular Center Research Institute
Role of Muscarinic K Channels in Parasympthetic Regulation of Heart BeatPrincipal Investigator
- Principal Investigator
  
  YAMADA Mitsuhiko
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
  National Cardiovascular Center Research Institute
動脈硬化血管の収縮異常と血管平滑筋型ATP感受性K^+チャネルPrincipal Investigator
- Principal Investigator
  
  山田充彦
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  National Cardiovascular Center Research Institute
Its functional significance and molecular mechanism
- Principal Investigator
  
  KURACHI Yoshihisa
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  General pharmacology
- Research Institution
  Osaka University
Investigation of Molecular Diversity of ATP-Sensitive K^+ Channels.
- Principal Investigator
  
  INANOBE Atsushi
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University Faculty of Medicine
Analysis of the polyamine-binding sites in inwardly rectifying K^+ channels.Principal Investigator
- Principal Investigator
  
  YAMADA Mitsuhiko
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  OSAKA UNIVERSITY
Studies of inwardly rectifying K^+ channels and an approach to develop new methods for assaying K^+ channel activity.
- Principal Investigator
  
  HORIO Yoshiyuki
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  General pharmacology
- Research Institution
  Osaka University
3量体G蛋白による心筋細胞カリウムチャネル制御の分子機構
- Principal Investigator
  
  倉智嘉久
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
内向き整流特性カリウムチャネルの神経伝達調節と可塑性における役割
- Principal Investigator
  
  倉智嘉久
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
内向き整流カリウムチャネルの細胞内物質によるゲーティング機構の解析Principal Investigator
- Principal Investigator
  
  山田充彦
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
Molecular Analysis of Inward Rectifier K^+channels in CNS
- Principal Investigator
  
  KURACHI Yoshihisa
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Osaka University
Molecular Mechanism in Regulation of Inwardly Rectifying Potassium Channel and its Functional Disorder
- Principal Investigator
  
  KURACHI Yoshisa
- Project Period (FY)
  1995 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Osaka University
NOによる中枢神経細胞内向き整流カリウムチャネルの抑制性修飾とその分子機構
- Principal Investigator
  
  KURACHI Yoshihisa
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
三量体G蛋白質による心筋細胞カリウムチャネル制御の分子機構
- Principal Investigator
  
  倉智嘉久
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
心筋細胞ATP依存性カリウムチャネルの受容体および機械刺激依存性制御とその異常
- Principal Investigator
  
  倉智嘉久
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
Molecular cloning of ATP-sensitive K^+ channels and development of the method evaluating K^+ channel openers.
- Principal Investigator
  
  KURACHI Yoshihisa
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University

[Book] 熱血　循環器学　（井上信孝　編）2019
- Author(s)
  山田充彦
- Total Pages
  244
- Publisher
  洋學社
- Data Source
  KAKENHI-PROJECT-18K06870
[Book] 熱血　循環器学2019
- Author(s)
  井上信孝、山田充彦
- Total Pages
  244
- Publisher
  洋學社
- ISBN
  9784908296147
- Data Source
  KAKENHI-PROJECT-18K06870
[Book] 心筋細胞とメカニカルストレス応答2009
- Author(s)
  山田充彦、南山堂横山光宏、井上信孝
- Publisher
  循環器ストレス学
- Data Source
  KAKENHI-PROJECT-21590275
[Book] 循環器ストレス学2009
- Author(s)
  山田充彦
- Total Pages
  9
- Publisher
  南山堂
- Data Source
  KAKENHI-PROJECT-21590275
[Book] 別冊・医学のあゆみイオンチャネルの最前線 update2005
- Author(s)
  山田充彦
- Total Pages
  7
- Publisher
  医歯薬出版株式会社
- Data Source
  KAKENHI-PROJECT-16590191
[Journal Article] Mature human induced pluripotent stem cell-derived cardiomyocytes promote angiogenesis through alpha-B crystallin2023
- Author(s)
  Tanaka Yuki、Kadota Shin、Zhao Jian、Kobayashi Hideki、Okano Satomi、Izumi Masaki、Honda Yusuke、Ichimura Hajime、Shiba Naoko、Uemura Takeshi、Wada Yuko、Chuma Shinichiro、Nakada Tsutomu、Tohyama Shugo、Fukuda Keiichi、Yamada Mitsuhiko、Seto Tatsuichiro、Kuwahara Koichiro、Shiba Yuji
- Journal Title
  
  Stem Cell Research and Therapy
  
  Volume: 14 Issue: 1 Pages: 240-240
- DOI
  10.1186/s13287-023-03468-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06828, KAKENHI-PROJECT-23K06332, KAKENHI-PROJECT-23K07328, KAKENHI-PROJECT-21K08100, KAKENHI-PROJECT-22K19521, KAKENHI-PROJECT-23K21433
[Journal Article] Increased predominance of the matured ventricular subtype in embryonic stem cell-derived cardiomyocytes in vivo2020
- Author(s)
  Ichimura Hajime、Kadota Shin、Kashihara Toshihide、Yamada Mitsuhiko、Ito Kuniaki、Kobayashi Hideki、Tanaka Yuki、Shiba Naoko、Chuma Shinichiro、Tohyama Shugo、Seto Tatsuichiro、Okada Kenji、Kuwahara Koichiro、Shiba Yuji
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 11883-11883
- DOI
  10.1038/s41598-020-68373-9
- NAID
  120007006223
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H04173, KAKENHI-PROJECT-18H02429, KAKENHI-PROJECT-18H02887, KAKENHI-PROJECT-20H03673, KAKENHI-PROJECT-18K06870, KAKENHI-PROJECT-19K17554, KAKENHI-PROJECT-19H00922
[Journal Article] beta-Arrestin-Biased AT1 Agonist, TRV027 Causes a Neonatal-Specific Sustained Positive Inotropic Effect without Increasing Heart Rate2020
- Author(s)
  Kashihara T, Kawagishi H, Nakada T, Numaga-Tomita T, Kadota S, Wolf EE, Du CK, Shiba Y, Morimoto S, Yamada M.
- Journal Title
  
  Journal of the American College of Cardiology
  
  Volume: 5 Issue: 11 Pages: 1057-1057
- DOI
  10.1016/j.jacbts.2020.08.011
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07116, KAKENHI-PROJECT-19K07299, KAKENHI-PROJECT-18K06870, KAKENHI-PROJECT-19K16488
[Journal Article] Effects of hypertension and antihypertensive treatments on sulfatide levels in serum and its metabolism2019
- Author(s)
  Guo Ran、Hu Xiao、Yamada Yosuke、Harada Makoto、Nakajima Takero、Kashihara Toshihide、Yamada Mitsuhiko、Aoyama Toshifumi、Kamijo Yuji
- Journal Title
  
  Hypertension Research
  
  Volume: 42 Issue: 5 Pages: 598-609
- DOI
  10.1038/s41440-018-0160-z
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06870, KAKENHI-PROJECT-18K08204, KAKENHI-PROJECT-19K17736
[Journal Article] Physical interaction of junctophilin and the CaV1.1 C terminus is crucial for skeletal muscle contraction2018
- Author(s)
  Nakada Tsutomu、Kashihara Toshihide、Komatsu Masatoshi、Kojima Katsuhiko、Takeshita Toshikazu、Yamada Mitsuhiko
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 115 Issue: 17 Pages: 4507-4512
- DOI
  10.1073/pnas.1716649115
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08491, KAKENHI-PROJECT-18K06870
[Journal Article] Association between motor evoked potentials and spinal cord damage diagnosed with magnetic resonance imaging after thoracoabdominal and descending aortic aneurysm repair2018
- Author(s)
  Hattori K, Yoshitani K, Kato S, Kawaguchi M, Kawamata M, Kakinohana M, Yamada Y, Yamakage M, Nishiwaki K, Izumi S, Yoshikawa Y, Mori Y, Hasegawa K, Onishi Y
- Journal Title
  
  J Cardiothorac Vasc Anesth
  
  Volume: 33 Issue: 7 Pages: 1-8
- DOI
  10.1053/j.jvca.2018.12.004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H02562, KAKENHI-PROJECT-17K16741
[Journal Article] PDGF-induced migration of synthetic vascular smooth muscle cells through c-Src-activated L-type Ca2+ channels with full-length CaV1.2 C-terminus2018
- Author(s)
  Xiaoguang Guo, Toshihide Kashihara, Tsutomu Nakada, Toshifumi Aoyama, Mitsuhiko Yamada
- Journal Title
  
  Pflugers Archiv - European Journal of Physiology
  
  Volume: 470 (6) Issue: 6 Pages: 909-921
- DOI
  10.1007/s00424-018-2114-3
- NAID
  130007812887
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08546, KAKENHI-PROJECT-18K06870
[Journal Article] Impact of chronic kidney dysfunction on serum Sulfatides and its metabolic pathway in mice2018
- Author(s)
  Yamada Yosuke、Harada Makoto、Hashimoto Koji、Guo Ran、Nakajima Takero、Kashihara Toshihide、Yamada Mitsuhiko、Aoyama Toshifumi、Kamijo Yuji
- Journal Title
  
  Glycoconjugate Journal
  
  Volume: 36 Issue: 1 Pages: 1-11
- DOI
  10.1007/s10719-018-9850-7
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06870, KAKENHI-PROJECT-18K08204, KAKENHI-PROJECT-19K17736
[Journal Article] Sonic hedgehog signaling regulates the mammalian cardiac regenerative response2018
- Author(s)
  Kawagishi Hiroyuki、Xiong Jianhua、Rovira Ilsa I.、Pan Haihui、Yan Ye、Fleischmann Bernd K.、Yamada Mitsuhiko、Finkel Toren
- Journal Title
  
  Journal of Molecular and Cellular Cardiology
  
  Volume: 123 Pages: 180-184
- DOI
  10.1016/j.yjmcc.2018.09.005
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06870
[Journal Article] Prostanoid EP4 receptor-mediated augmentation of Ih currents in Aβ dorsal root ganglion neurons underlies neuropathic pain2018
- Author(s)
  Zhang H, Kashihara T, Nakada T, Tanaka S, Ishida K, Fuseya S, Kawagishi H, Kiyosawa K, Kawamata M, Yamada M
- Journal Title
  
  Journal of Pharmacology and Experimental Therapeutics
  
  Volume: 368 Issue: 1 Pages: 50-58
- DOI
  10.1124/jpet.118.252767
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02562, KAKENHI-PROJECT-18K06870
[Journal Article] Endothelium-derived C-type natriuretic peptide contributes to blood pressure regulation by maintaining endothelial integrity.2017
- Author(s)
  Nakao K, Kuwahara K, Nishikimi T, Nakagawa Y, Kinoshita H, Minami T, Kuwabara Y, Yamada C, Yamada Y, Tokudome T, Nagai-Okatani C, Minamino N, Nakao YM, Yasuno S, Ueshima K, Sone M, Kimura T, Kangawa K, Nakao K
- Journal Title
  
  Hypertension.
  
  Volume: 69 Issue: 2 Pages: 286-296
- DOI
  10.1161/hypertensionaha.116.08219
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293187, KAKENHI-PROJECT-16K15495, KAKENHI-PROJECT-16K15442, KAKENHI-PROJECT-16K09498, KAKENHI-PROJECT-26461380, KAKENHI-PROJECT-17H01566, KAKENHI-PROJECT-17H04174, KAKENHI-PROJECT-15K09137, KAKENHI-PROJECT-15K09138
[Journal Article] Systematic review of motor evoked potentials monitoring during thoracic and thoracoabdominal aortic aneurysm open repair surgery: a diagnostic meta-analysis2016
- Author(s)
  Tanaka Y, Kawaguchi M, Noguchi Y, Yoshitani K, Kawamata M, Masui K, Nakayama T, Yamada Y
- Journal Title
  
  J Anesth
  
  Volume: 30 Issue: 6 Pages: 1037-1050
- DOI
  10.1007/s00540-016-2242-x
- NAID
  40021034848
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H02562, KAKENHI-PROJECT-15K15568
[Journal Article] The renin-angiotensin system promotes arrhythmogenic substrates andalethal arrhythmias in mice with non-ischemic cardiomyopathy2016
- Author(s)
  Yamada C, Kuwahara K, Yamazaki M, Nakagawa Y, Nishikimi T, Kinoshita H, Kuwabara Y, Minami T, Yamada Y, Shibata J, Nakao K, , Arai Y, Honjo H, Kamiya K, Nakao K, Kimura T
- Journal Title
  
  Cardiovascular Research
  
  Volume: 109 Issue: 1 Pages: 162-173
- DOI
  10.1093/cvr/cvv248
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09078, KAKENHI-PROJECT-15K09138, KAKENHI-PROJECT-15K19377, KAKENHI-PROJECT-25461107, KAKENHI-PROJECT-26670400, KAKENHI-PROJECT-25293182, KAKENHI-PROJECT-26293187, KAKENHI-PROJECT-16K09498
[Journal Article] Pro-B-type natriuretic peptide is cleaved intracellularly: impact of distance between O-glycosylation and cleavage sites.2015
- Author(s)
  Nishikimi T, Nakagawa Y, Minamino N, Ikeda M, Tabei K, Fujishima A, Takayama K, Akimoto K, Yamada C, Nakao K, Minami T, Kuwabara Y, Kinoshita H, Tsutamoto T, Ishimitsu T, Kangawa K, Kuwahara K, Nakao K
- Journal Title
  
  Am J Physiol Regul Integr Comp Physiol.
  
  Volume: 309 Issue: 6 Pages: R639-R649
- DOI
  10.1152/ajpregu.00074.2015
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K09138, KAKENHI-PROJECT-15K19377, KAKENHI-PROJECT-26670400, KAKENHI-PROJECT-26293187
[Journal Article] Inhibition of N-type Ca2+ channels ameliorates an imbalance in cardiac autonomic nerve activity and prevents lethal arrhythmias in mice with heart failure.2014
- Author(s)
  Yamada Y, Kinoshita H, Kuwahara K, Nakagawa Y, Kuwabara Y, Minami T, Yamada C, Shibata J, Nakao K, Cho K, Arai Y, Yasuno S, Nishikimi T, Ueshima K, Kamakura S, Nishida M, Kiyonaka S, Mori Y, Kimura T, Kangawa K, Nakao K.
- Journal Title
  
  Cardiovasc Research
  
  Volume: 104 Issue: 1 Pages: 183-193
- DOI
  10.1093/cvr/cvu185
- NAID
  120005619790
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591095, KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-25293182, KAKENHI-PROJECT-25460749, KAKENHI-PROJECT-25461107, KAKENHI-PROJECT-25860596, KAKENHI-PROJECT-25860597, KAKENHI-PLANNED-26111011, KAKENHI-PROJECT-26293187, KAKENHI-PROJECT-26670400, KAKENHI-PROJECT-26670458
[Journal Article] The effects of super-flux (high performance) dialyzer on plasma glycosylated pro-B-type natriuretic peptide (proBNP) and glycosylated N-Terminal proBNP in end-stage renal disease patients on dialysis.2014
- Author(s)
  Nakagawa Y, Nishikimi T, Kuwahara K, Yasuno S, Kinoshita H, Kuwabara Y, Nakao K, Minami T, Yamada C, Ueshima K, Ikeda Y, Okamoto H, Horii K, Nagata K, Kangawa K, Minamino N, Nakao K.
- Journal Title
  
  PLoS One
  
  Volume: 25 Issue: 3 Pages: e92314-e92314
- DOI
  10.1371/journal.pone.0092314
- NAID
  120007100132
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23310155, KAKENHI-PROJECT-23390210, KAKENHI-PROJECT-24591095, KAKENHI-PROJECT-24659386, KAKENHI-PUBLICLY-25126712, KAKENHI-PROJECT-25460749, KAKENHI-PROJECT-25461107, KAKENHI-PROJECT-25860596, KAKENHI-PROJECT-25860597, KAKENHI-PROJECT-26293187, KAKENHI-PROJECT-26670400, KAKENHI-PROJECT-26670458
[Journal Article] Molecular mechanism of junctional membrane-targeting of cardiac and skeletal muscle L-type calcium channels2014
- Author(s)
  中田　勉，山田　充彦
- Journal Title
  
  Folia Pharmacologica Japonica
  
  Volume: 144 Issue: 5 Pages: 217-221
- DOI
  10.1254/fpj.144.217
- NAID
  130004704235
- ISSN
  0015-5691, 1347-8397
- Language
  Japanese
- Open Access
- Data Source
  KAKENHI-PROJECT-24590271
[Journal Article] Chronic receptor-mediated activation of Gi/o proteins alters basal t-tubular and sarcolemmal L-type Ca^<2+> channel activity through phosphatases in heart failure2012
- Author(s)
  Kashihara, T., Nakada, T., Shimojo, H., Horiuchi-Hirose, M., Gomi, S., Shibazaki, T., Sheng, X., Hirose, M., Hongo, M., and Yamada, M
- Journal Title
  
  Am. J. Physiol. Heart Circ. Physiol
  
  Volume: 302 Issue: 8 Pages: 1645-1654
- DOI
  10.1152/ajpheart.00589.2011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590275, KAKENHI-PROJECT-22790206
[Journal Article] Two mechanistically distinct effects of dihydro pyridine nifedipine on Ca^V〈1. 2〉L-type Ca^<2+> channels revealed by Timothy syndrome mutation2012
- Author(s)
  Sheng, X., Nakada, T., Kobayashi, M., Kashihara, T., Shibazaki, T., Horiuchi-Hirose, M., Gomi, S., Hirose, M., Aoyama, T., Yamada, M
- Journal Title
  
  Eur. J. Pharmacol
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590275
[Journal Article] – Roles of Canonical Transient Receptor Potential (TRPC) Channels –2011
- Author(s)
  Hirose, M., Takeishi, Y., Niizeki, T., Nakada, T., Shimojo, H., Kashihara, T., Horiuchi-Hirose, M., Kubota, I., Mende, U., Yamada, M
- Journal Title
  
  Circ J
  
  Volume: 75 Issue: 10 Pages: 2333-2342
- DOI
  10.1253/circj.CJ-10-1213
- NAID
  10029459214
- ISSN
  1346-9843, 1347-4820
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590275, KAKENHI-PROJECT-22790206
[Journal Article] Nicorandil ameliorates impulseconduction disturbances during ischemia in isolated arterially perfused canine atria2011
- Author(s)
  Hirose, M., Yano, S., Nakada, T., Horiuchi-irose, M., Tsujino, N., Yamada, M
- Journal Title
  
  Int. J. Cardiol
  
  Volume: 146 Issue: 1 Pages: 37-43
- DOI
  10.1016/j.ijcard.2009.06.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590275
[Journal Article] Decrease in the density of t-tubular L-type Ca^<2+> channel currents in failing ventricular my cytes2011
- Author(s)
  Horiuchi-Hirose, M., Kashihara, T., Nakada, T., Kurebayashi, N., Shimojo, H., Shibazaki, T., Sheng, X., Yano, S., Hirose, M., Hongo, M., Sakurai, T., Moriizumi, T., Ueda, H., and Yamada, M
- Journal Title
  
  Am. J. Physiol. Heart Circ. Physiol
  
  Volume: 300(3) Issue: 3 Pages: 978-988
- DOI
  10.1152/ajpheart.00508.2010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590275
[Journal Article] Acid-sensing ion channels in blood volume regulation.2011
- Author(s)
  Yamada, M
- Journal Title
  
  Circulation Journal
  
  Volume: 75 Pages: 781-782
- NAID
  10028102876
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590275
[Journal Article] Thrombin activates Ca^<2+>-permeating nonselective cation channels through protein kinase C in human umbilical vein endothelial cells2011
- Author(s)
  Tsujino, N, Nakada, T., Tsubouchi, K., Kobayashi, M., Kawai, Y., Yano, S., Matsunaga, T., Hirose, M., Ohmori, S., Ohhashi, T., Yamada, M
- Journal Title
  
  Shinshu Med. J
  
  Volume: 59 Pages: 13-26
- NAID
  130004810183
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590275
[Journal Article] Acid-Sensing Ion Channels in Blood Volume Regulation2011
- Author(s)
  Yamada, M
- Journal Title
  
  Circ J
  
  Volume: 75 Issue: 4 Pages: 781-782
- DOI
  10.1253/circj.CJ-11-0085
- NAID
  10028102876
- ISSN
  1346-9843, 1347-4820
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590275
[Journal Article] Selectiveα_〈1A〉-adrenoceptor stimulation induces Mueller' s smooth muscle contraction in an isolated canine upper eyelid preparation2010
- Author(s)
  Yano, S., Hirose, M., Nakada, T., Nakayama, J., Matsuo, K., Yamada, M
- Journal Title
  
  Curr. Eye Res
  
  Volume: 35 Issue: 5 Pages: 363-369
- DOI
  10.3109/02713680903518858
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590275
[Journal Article] Mitochondrial ATP-sensitive K^+ channels, protectors of the heart2010
- Author(s)
  Yamada, M
- Journal Title
  
  J. Physiol.(Lond)
  
  Volume: 582 Issue: 2 Pages: 283-286
- DOI
  10.1113/jphysiol.2009.179028
- NAID
  120007110425
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590275
[Journal Article] Diaclglycerol seζinhibits G_〈αq〉-induced atrial remodeling in transgenic mice2009
- Author(s)
  Hirose, M., Takeishi, Y., Niizeki, T., Shimojo, H., Nakada, T., Kubota, I., Nakayama J., Mende, U., Yamada, M
- Journal Title
  
  Heart Rhythm
  
  Volume: 6 Pages: 78-84
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590275
[Journal Article] Mitochondrial ATP-sensitive K^+ channels, protectors of the heart.2009
- Author(s)
  Yamada, M.
- Journal Title
  
  J.Physiol.(Lond.) 582
  
  Pages: 283-286
- NAID
  120007110425
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590275
[Journal Article] ATP感受性K^+チャネルの分子薬理学2006
- Author(s)
  山田充彦
- Journal Title
  
  心電図 26・1
  
  Pages: 4-10
- NAID
  10016945150
- Data Source
  KAKENHI-PROJECT-16590191
[Journal Article] A functional role of the C-terminal 42 amino acids of SUR2A and SUR2B in the physiology and pharmacology of cardiovascular ATP-sensitive K^+ channels.2005
- Author(s)
  Yamada, M., Kurachi, Y.
- Journal Title
  
  Journal of Molecular Cellular Cardiology 39
  
  Pages: 1-6
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590191
[Journal Article] A functional role of the C-terminal 42 amino acids of SUR2A and SUR2B in the physiology and pharmacology of cardiovascular ATP-sensitive K^+ channels.2005
- Author(s)
  Yamada M
- Journal Title
  
  J Mol Cell Cardiol 39(1)
  
  Pages: 1-6
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15209008
[Journal Article] A functional role of the C-terminal 42 amino acids of SUR2A and SUR2B in the physiology and pharmacology of cardiovascular ATP-sensitive K^+ channels.2005
- Author(s)
  Yamada, M., Kurachi, Y.
- Journal Title
  
  J. Mol. Cell. Cardiol 39
  
  Pages: 1-6
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590191
[Journal Article] A functional role of the C-terminal 42 amino acids of SUR2A and SUR2B in the physiology and pharmacology of cardiovascular ATP-sensitive K^+ channels.2005
- Author(s)
  M.Yamada, Y.Kurachi
- Journal Title
  
  Journal of Molecular and Cellular Cardiology (in press)
- Data Source
  KAKENHI-PROJECT-16590191
[Journal Article] A functional role of the C-terminal 42 amino acids of SUR2A and SUR2B in the physiology and pharmacology of cardiovascular ATP-sensitive K(+) channels.2005
- Author(s)
  Yamada, M.
- Journal Title
  
  J.Mol.Cell.Cardiol. 39・1
  
  Pages: 1-6
- Data Source
  KAKENHI-PROJECT-15209008
[Journal Article] ATP感受性K^+(K_<ATP>)チャネル制御の機能構造的理解2005
- Author(s)
  倉智嘉久, 山田充彦
- Journal Title
  
  日薬理誌 126
  
  Pages: 311-316
- NAID
  10016912800
- Data Source
  KAKENHI-PROJECT-16590191
[Journal Article] PtdIns(3,4,5)P3 and Ca^<2+>/calmodulin competitively bind to the RGS domain of RGS4 and reciprocally regulate its action.2005
- Author(s)
  Ishii, M., Fujita, S., Yamada, M., Hosaka, Y., Kurachi, Y.
- Journal Title
  
  Biochem. J. 385
  
  Pages: 65-73
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590191
[Journal Article] Mutation in nucleotide-binding domains of sulfonylurea receptor 2 evokes Na-ATP-dependent activation of ATP-sensitive K^+ channels : Implication for dimerization of nucleotide-binding domains to induce channel opening.2004
- Author(s)
  Yamada, M., Ishii, M., Hibino, H., Kurachi, Y.
- Journal Title
  
  Mol Pharmacol 66
  
  Pages: 807-816
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590191
[Journal Article] Mutation in nucleotide-binding domains of sulfonylurea receptor 2 evokes Na-ATP-dependent activation of ATP-sensitive K^+ channels : implication for dimerization of nucleotide-binding domains to induce channel opening.2004
- Author(s)
  Yamada M
- Journal Title
  
  Mol Pharmacol 66(4)
  
  Pages: 807-816
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15209008
[Journal Article] Mutation in nucleotide-binding domains of sulfonylurea receptor 2 evokes Na-ATP-dependent activation of ATP-sensitive K^+ channels.2004
- Author(s)
  M.Yamada et al.
- Journal Title
  
  Molecular Pharmacology 66
  
  Pages: 807-816
- Data Source
  KAKENHI-PROJECT-16590191
[Journal Article] The nucleotide-binding domains of sulfonylurea receptor 2A and 2B play different functional roles in nicorandil-induced activation of ATP-sensitive K^+ channels.2004
- Author(s)
  Yamada M
- Journal Title
  
  Mol Pharmacol 65(5)
  
  Pages: 1198-1207
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15209008
[Journal Article] Mutation in nucleotide-binding domains of sulfonylurea receptor 2 evokes Na-AIP-dependent activation of ATP-Sensitive K^+ Channels : Implication for dimerization of nucleotide-binding domains to induce channel opening.2004
- Author(s)
  Yamada, M., Ishii, M.et al.
- Journal Title
  
  Molecular Pharmacology 66・4
  
  Pages: 807-816
- Data Source
  KAKENHI-PROJECT-15209008
[Journal Article] Comparison of kinetic properties of quinidine and dofetilide block of HERG channels.2004
- Author(s)
  Tsujimae, K., Suzuki, S., Yamada, M., Kurachi, Y.
- Journal Title
  
  Eur. J. Pharmacol 493
  
  Pages: 29-40
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590191
[Journal Article] Differential assembly of inwardly rectifying K^+ channel subunits, Kir4.1 and Kir5.1, in brain astrocytes.2004
- Author(s)
  Hibino, H., Fujita, A., Iwai, K., Yamada, M., Kurachi, Y.
- Journal Title
  
  J Biol Chem 279
  
  Pages: 44065-44073
- NAID
  130005446853
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590191
[Journal Article] The nucleotide-binding domains of sulfonylurea receptor 2A and 2B play different functional roles in nicorandil-induced activation of ATP-sensitive K^+ channels.2004
- Author(s)
  Yamada, M., Kurachi, Y.
- Journal Title
  
  Molecular Pharmacology 65
  
  Pages: 1198-1207
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590191
[Journal Article] Mutation in nucleotide-binding domains of sulfonylurea receptor 2 evokes Na-ATP-dependent activation of ATP-sensitive K^+ channels : Implication for dimerization of nucleotide-binding domains to induce channel opening.2004
- Author(s)
  Yamada, M., et al.
- Journal Title
  
  Molecular Pharmacology 66
  
  Pages: 807-816
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590191
[Journal Article] The nucleotide-binding domains of sulfonylurea receptor 2A and 2B play different functional roles in nicorandil-induced activation of ATP-sensitive K^+ channels.2004
- Author(s)
  Yamada, M., Kurachi, Y.
- Journal Title
  
  Mol Pharmacol 65
  
  Pages: 1198-1207
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590191
[Journal Article] Mutation in nucleotide-binding domains of sulfonylurea receptor 2 evokes Na-ATP-dependent activation of ATP-sensitive K^+ channels: implication for dimerization of nucleotide-binding domains to induce channel opening.2004
- Author(s)
  Yamada M
- Journal Title
  
  Mol Pharmacol 66(4)
  
  Pages: 807-816
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15209008
[Presentation] アンジオテンシンIIの新生児・乳児期特異的心臓作用の発見から小児心不全治療薬へ2024
- Author(s)
  川岸裕幸、中嶌岳郎、Risa Ramadhiani、中田勉、冨田拓郎、諫田泰成、江本憲昭、山田充彦
- Organizer
  第33回日本循環薬理学会
- Invited
- Data Source
  KAKENHI-PROJECT-23K06332
[Presentation] 薬理学における電気生理学的手法の未来と可能性2023
- Author(s)
  山田充彦
- Organizer
  第97回日本薬理学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-23K06332
[Presentation] Molecular mechanism underlying cardiac early afterdepolarization induced by IKr and IKs suppression2020
- Author(s)
  Mitsuhiko YAMADA, Toshihide KASHIHRA, Hitoshi NISHIMURA
- Organizer
  The 11th Annual Meeting of Japanese Safety Pharmacology Society
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06870
[Presentation] 新たな方法でAT1 受容体を利用した小児心不全治療薬の開発2020
- Author(s)
  川岸裕幸、山田充彦
- Organizer
  第143回日本薬理学会関東部会
- Data Source
  KAKENHI-PROJECT-18K06870
[Presentation] Ca2+チャネルアゴニストFPL64176の分子作用メカニズム2020
- Author(s)
  山田充彦
- Organizer
  第143回日本薬理学会関東部会
- Data Source
  KAKENHI-PROJECT-18K06870
[Presentation] βアレスチンバイアスアンジオテンシン1型受容体アゴニストは、新生児特有の持続性陽性変力作用を示す2020
- Author(s)
  川岸裕幸、柏原俊英、冨田拓郎、中田勉、山田充彦
- Organizer
  第142回日本薬理学会関東部会
- Data Source
  KAKENHI-PROJECT-18K06870
[Presentation] 血管平滑筋細胞におけるL型電位依存性カルシウムチャネルとストア作動性カルシウムチャネルの関係性解明2020
- Author(s)
  冨田拓郎、小林誠、川岸裕幸、中田勉、山田充彦
- Organizer
  第30回日本循環薬理学会
- Data Source
  KAKENHI-PROJECT-18K06870
[Presentation] 小胞体CaセンサーSTIM1によるCaV1.2チャネル抑制メカニズムの解明2020
- Author(s)
  冨田拓郎、高橋弘毅、山田充彦
- Organizer
  第142回日本薬理学会関東部会
- Data Source
  KAKENHI-PROJECT-18K06870
[Presentation] ジャンクトフィリン2変異体の強制発現による心機能低下2020
- Author(s)
  中田勉、川岸裕幸、冨田拓郎、山田充彦
- Organizer
  第67回中部日本生理学会
- Data Source
  KAKENHI-PROJECT-18K06870
[Presentation] Postnatal loss of gp130 caused impaired cardiac contractility accompanied by inhibition of physiological proliferation of cardiomyocytes.2020
- Author(s)
  Hiroyuki Kawagishi, Tsutomu Nakada, Takuro Numaga-Tomita, Mitsuhiko Yamada
- Organizer
  NIPS International Meeting on Cardiovascular Physiology 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06870
[Presentation] HCN チャネル阻害薬による神経障害性疼痛の治療法2020
- Author(s)
  冨田（沼賀）拓郎、川真田樹人、山田充彦
- Organizer
  第143回日本薬理学会関東部会
- Data Source
  KAKENHI-PROJECT-18K06870
[Presentation] AT1受容体／βアレスチン経路は小児心不全の治療標的となる2020
- Author(s)
  山田充彦
- Organizer
  第12回日本安全性薬理研究会・学術年会
- Invited
- Data Source
  KAKENHI-PROJECT-18K06870
[Presentation] 小児心不全では、AT1アンジオテンシン受容体を抑制すべきか刺激すべきか？2020
- Author(s)
  山田充彦
- Organizer
  第56回日本小児循環器学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-18K06870
[Presentation] アンギオテンシンII 1型受容体-βアレスチン経路を活性化する小児心不全治療薬の開発2020
- Author(s)
  川岸裕幸、柏原俊英、冨田拓郎、中田勉、山田充彦
- Organizer
  第30回日本循環薬理学会
- Data Source
  KAKENHI-PROJECT-18K06870
[Presentation] A beta arrestin-bias AT1 receptor agonist improves the survival of neonatal knock-in mice bearing a human dilated cardiomyopathy mutation2019
- Author(s)
  Yamada, M
- Organizer
  The 50th NIPS International Symposium. ‘MIRACLES’ in Cardiovascular Physiology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06870
[Presentation] Interaction of junctophilins and the CaV1.1 is essential for the skeletal muscle contraction2019
- Author(s)
  Tsutomu Nakada, Toshihide Kashihara, Masatoshi Komatsu, Mitsuhiko Yamada
- Organizer
  FAOPS 2019
- Data Source
  KAKENHI-PROJECT-18K06870
[Presentation] Molecular mechanism underlying cardiac early afterdepolarization induced by IKr and IKs suppression2019
- Author(s)
  Mitsuhiko YAMADA, Toshihide KASHIHRA, Hitoshi NISHIMURA
- Organizer
  Japanese Safety Pharmacology Society
- Invited
- Data Source
  KAKENHI-PROJECT-18K06870
[Presentation] EP4 receptor-mediated augmentation of Ih currents in A-beta DRG neurons underlies neuropathic pain2019
- Author(s)
  31.Yamada, M., Zhang, H., Kashihara, T., Nakada, T., Tanaka, S., Ishida, K., Fuseya, S., Kawagishi, H., Kiyosawa, K., Kawamata, M.
- Organizer
  FAOPS 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06870
[Presentation] Molecular mechanisms underlying spatiotemporal regulation of L-type Ca2+ channels in muscles.2019
- Author(s)
  Yamada, M.
- Organizer
  ogic of life: ion channel structure, function and physiology. International commemorative symposium in celebration of retirement of Professor Yoshihisa Kurachi
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06870
[Presentation] PDGF induces migration of synthetic vascular smooth muscle cells through c-Src-dependent activation of full-length CaV1.2 L-type Ca2+ channels2018
- Author(s)
  Kashihara, T., Guo, X., Nakada, T., Yamada, M.
- Organizer
  18th World Congress of Basic and Clinical Pharmacology (WCP2018)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06870
[Presentation] Physical interaction of junctophilins and CaV1.1 subunits is essential for the excitation-contraction coupling of the skeletal muscle.2018
- Author(s)
  Nakada, T., Kashihara, T., Komatsu, M., Yamada, M.
- Organizer
  18th World Congress of Basic and Clinical Pharmacology (WCP2018)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06870
[Presentation] 除神経骨格筋におけるL型カルシウムチャネルβサブユニットの発現増加2016
- Author(s)
  小松雅俊, 中田勉, 山本竜星, 柏原俊英, 山田充彦
- Organizer
  第89回日本薬理学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-03-10
- Data Source
  KAKENHI-PROJECT-25670641
[Presentation] Unprocessed proBNP secretion is regulated by MiR30-GALNTs axis dependent O-glycosylation in the pathological myocardium.2016
- Author(s)
  Nakagawa Y, Nishikimi T, Kuwahara K, Kinoshita H, Yamada C, Inazumi H, Nakao K, Kimura T
- Organizer
  AHA BCVS2016
- Place of Presentation
  Phoenix, Arizona, USA
- Year and Date
  2016-07-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293187
[Presentation] O型糖鎖修飾を介したヒトBNPプロセシング調節に関与する糖転移酵素についての検討2015
- Author(s)
  中川靖章、錦見俊雄、桑原宏一郎、木下秀之,山田千夏、南野直人、中尾一和、木村剛
- Organizer
  第19回　日本心血管内分泌代謝学会学術集会
- Place of Presentation
  神戸
- Year and Date
  2015-12-10
- Data Source
  KAKENHI-PROJECT-26293187
[Presentation] 心不全患者におけるproBNPの分泌と代謝についての検討2015
- Author(s)
  中川靖章、錦見俊雄、桑原宏一郎、木下秀之,山田千夏、南野直人、中尾一和、木村剛
- Organizer
  第19回　日本心血管内分泌代謝学会学術集会
- Place of Presentation
  神戸
- Year and Date
  2015-12-10
- Data Source
  KAKENHI-PROJECT-26293187
[Presentation] N-type Ca2+ channels blockade restores the cardiac autonomic balance and prevents lethal arrhythmias in mice with dilated cardiomyopathy2015
- Author(s)
  Koichiro Kuwahara, Yuko Yamada, Hideyuki Kinoshita, Yasuaki Nakagawa, Kazuwa Nakao and Takeshi Kimura
- Organizer
  25th European Meeting on Hypertension and Cardiovascular Protection　(European Society of Hypertension)
- Place of Presentation
  ミラノ
- Year and Date
  2015-06-12
- Data Source
  KAKENHI-PROJECT-26293187
[Presentation] ジャンクトフィリンはCaV1.1サブユニットのC末端と結合し，骨格筋L型カルシウムチャネルの局在を制御する2014
- Author(s)
  中田勉，Bernhard E Flucher，柏原俊英，小松雅俊，山田充彦
- Organizer
  第91回日本生理学会大会
- Place of Presentation
  鹿児島大学（鹿児島県鹿児島市）
- Data Source
  KAKENHI-PROJECT-24590271
[Presentation] 横紋筋L型カルシウムチャネルの結合膜局在化機構2014
- Author(s)
  中田勉，Bernhard E Flucher，柏原俊英，小松雅俊，山田充彦
- Organizer
  第87回日本薬理学会年会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Data Source
  KAKENHI-PROJECT-24590271
[Presentation] Junctophilin knockdown alters the localization and function of L-type calcium channels and ryanodine receptors in C2C12 myotubes.2013
- Author(s)
  Tsutomu Nakada, Bernhard Flucher, Toshihide Kashihara, Gomi Simmon, Mitsuhiko Yamada
- Organizer
  第86回日本薬理学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24590271
[Presentation] Effect of junctophilin knockdown on the localization and function of L-type calcium channels and ryanodine receptors in skeletal myotubes.2013
- Author(s)
  Tsutomu Nakada, Bernhard Flucher, Toshihide Kashihara, Gomi Simmon, Mitsuhiko Yamada
- Organizer
  第90回日本生理学会大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24590271
[Presentation] I_<Kr>and I_<Kr>channel suppressn cses early after depolarizations by preventing deactivation L-type Ca^<2+> channs in ventricular myocytes2009
- Author(s)
  Yamada, M., Ohta, K., Niwa, A., Tsujino, N., akada, T. and Hirose, M
- Organizer
  The 36th International Congress of Physiological Sciences
- Place of Presentation
  Kyoto, Japan
- Data Source
  KAKENHI-PROJECT-21590275
[Presentation] Role of O-glycosylation in N-terminal region of human proBNP in its processing mechanisms
- Author(s)
  Yasuaki Nakagawa, Toshio Nishikimi, Koichiro Kuwahara, Shinji Yasuno, Hideyuki Kinoshita, Yoshihiro Kuwabara, Kazuhiro Nakao, Chinatsu Yamada, Kenji Ueshima, Naoto Minamino, Takeshi Kimura, Kazuwa Nakao
- Organizer
  AHA Scientific Sessoins 2014
- Place of Presentation
  Chicago
- Year and Date
  2014-11-15 – 2014-11-19
- Data Source
  KAKENHI-PROJECT-26293187
[Presentation] Pivotal involvement of renin-angiotensin system in promoting arrhythmogenic remodeling in mice with chronic heart failure and lethal arrhythmias
- Author(s)
  Chinatsu Yamada, Koichiro Kuwahara, Hideyuki Kinoshita,Yasuaki Nakagawa, Toshio　Nishikimi Kazuwa Nakao, Takeshi Kimura
- Organizer
  第18回日本心不全学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2014-10-10 – 2014-10-12
- Data Source
  KAKENHI-PROJECT-26293187
[Presentation] Increased Expression of HCN channels in the Ventricular Myocardium Contributes to Enhanced Arrhythmicity in Mouse Failing Hearts
- Author(s)
  Yoshihiro Kuwabara, Koichiro Kuwahara, Makoto Takano, Hideyuki Kinoshita, Yuji Arai, Yasuaki Nakagawa, Shinji Ysuno, Sachiyo Igata, Satoru Usami, Takeya Minami, Yuko Yamada, Kazuhiro Nakao, Chinatsu Yamada, Junko Shibata, Toshio Nishikimi,Kenji Ueshima, Kazuwa Nakao
- Organizer
  第31回日本心電学会学術集会
- Place of Presentation
  東京
- Year and Date
  2014-07-22 – 2014-07-25
- Data Source
  KAKENHI-PROJECT-26293187
[Presentation] Critical involvement of renin-angiotensin system for developing arrhythmogenic remodeling in mice with chronic heart failure and lethal arrhythmias
- Author(s)
  C. Yamada, K. Kuwahara, Y. Kuwabara, H. Kinoshita, Y. Nakagawa, T. Nihikimi, K. Nakao, T. Kimura
- Organizer
  ESC 2014.8.30-9.3
- Place of Presentation
  Barcelona
- Year and Date
  2014-08-30 – 2014-09-03
- Data Source
  KAKENHI-PROJECT-26293187
[Presentation] 拡張型心筋症モデルマウスにおけるN型Ca2+チャネル阻害は自律神経バランスを改善し突然死を予防する
- Author(s)
  桑原宏一郎、山田優子、木下秀之、中川靖章、柴田純子、山田千夏、森泰生、中尾一和、木村剛
- Organizer
  第37回　日本高血圧学会総会
- Place of Presentation
  横浜
- Year and Date
  2014-10-17 – 2014-10-19
- Data Source
  KAKENHI-PROJECT-26293187
[Presentation] 脳性(B型)ナトリウム利尿ペプチド前駆体proBNPプロセシングにおける糖鎖結合の役割
- Author(s)
  中川靖章、錦見俊雄、桑原宏一郎、木下秀之、桒原佳宏、山田千夏、中尾一泰、保野慎治、上嶋健治、木村剛、南野直人、中尾一和
- Organizer
  第51回　日本臨床分子医学会
- Place of Presentation
  東京
- Year and Date
  2014-04-11 – 2014-04-12
- Data Source
  KAKENHI-PROJECT-26293187

1. KURACHI Yoshihisa (30142011)

# of Collaborated Projects: 10 results

# of Collaborated Products: 0 results
2. HORIO Yoshiyuki (30181530)

# of Collaborated Projects: 10 results

# of Collaborated Products: 0 results
3. TAKUMI Toru (00222092)

# of Collaborated Projects: 8 results

# of Collaborated Products: 0 results
4. INANOBE Atsuhi (00270851)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
5. 高橋尚彦 (30263239)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
6. NAKADA Tsutomu (70452141)

# of Collaborated Projects: 4 results

# of Collaborated Products: 15 results
7. ISOMOTO Shojiro (80273671)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
8. SUGA Michiharu (80265397)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. TANEMOTO Masayuki (40303945)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. KASHIHARA Toshihide (20552334)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
11. SUZUKI Suechika (10082174)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. KATO Hiroyuki (40204490)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. UCHIYAMA Shigeharu (10242679)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. HIGUCHI Keiichi (20173156)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. HORI Masatsugu (20124779)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. NAKATANI Takeshi (60155752)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. HIDAKA Kyoko (00216681)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. HIBINO Hiroshi (70314317)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. ISHII Masaru (10324758)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
20. Kawamata Mikito (90315523)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
21. Ueda Hiroshi (00145674)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. KUWAHARA Koichiro (30402887)

# of Collaborated Projects: 1 results

# of Collaborated Products: 13 results
23. TAKANO makoto (30236252)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
24. ARAI yuji (30202724)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
25. MORI yasuo (80212265)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
26. NISHIDA motohiro (90342641)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
27. 富田伸司 (30260730)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. 上園保仁 (20213340)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. 石田高志 (60531952)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
30. 木村忠史 (60344214)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. 杉山由紀 (10468100)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. 木下秀之 (30467477)

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results
33. 中川靖章 (70452357)

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results
34. DAVID Chella S

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
35. CLAPHAM David E.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
36. CHELLA S Dav

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
37. 由谷親夫

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
38. Neubig Richard

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
39. Olson Eric N.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
40. YAMAZAKI Masatoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
41. 柴祐司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
42. 南野直人

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
43. 錦見俊雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
44. 冨田拓郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
45. 本荘晴朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yamada Mitsuhiko 山田 充彦

山田 充彦 ヤマダ ミツヒコ

YAMADA Mitsuhiko 山田 充彦

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Analyses of the molecular mechanism underlying and the functional significance of developmental changes in intracellular signal transduction systems coupled to cardiac AT1 receptors.Principal Investigator

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Identification of factors promoting final differentiation of cardiac myocytes after birthPrincipal Investigator

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Quantitative analysis of the open-state affinity of L-type calcium channel blockers and modeling of their inhibitory actionsPrincipal Investigator

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Analysis of the molecular mechanism underlying the regulation of ATP-sensitive K+ channels by drugsPrincipal Investigator

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Role of Muscarinic K Channels in Parasympthetic Regulation of Heart BeatPrincipal Investigator

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動脈硬化血管の収縮異常と血管平滑筋型ATP感受性K^+チャネルPrincipal Investigator

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Yamada Mitsuhiko 山田充彦

山田充彦ヤマダミツヒコ

YAMADA Mitsuhiko 山田充彦

[Book] 熱血　循環器学　（井上信孝　編）2019