HORIO Masatsugu 堀正二

… Alternative Names

Researcher Number	20124779
Other IDs
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Affiliation (based on the past Project Information) *help	2004 – 2007: 大阪大学, 医学系研究科, 教授 2005: 大阪大学, 医学系研究科・酔う需 1999 – 2002: Osaka University Graduate School of Medicine, Professor, 医学系研究科, 教授 1996 – 1998: Faculty of Medicine, Osaka University, Professor, 医学部, 教授 1996: 大阪大学, 医学部附属病院, 講師 … More
Review Section/Research Field	Principal Investigator Circulatory organs internal medicine / Circulatory organs internal medicine Except Principal Investigator Circulatory organs internal medicine / Circulatory organs internal medicine
Keywords	Principal Investigator アデノシン / 心不全 / adenosine / Mn-SOD / プレコンディショニング / 心肥大 / 心筋梗塞 / Na^+ / α_1アドレナリン受容体 / ischemic preconditioning … More Except Principal Investigator 心不全 / アデノシン / 動脈硬化 / ecto-5'-nucleotidase / PKC / ずり応力 / 血管内皮細胞 / 急性心筋梗塞 / ATP / Adenosine / 心筋梗塞 / Mn-SOD / 心肥大 / 心筋細胞 / atherosclerosis / Shear Stress / Doppler / Reperfusion / 5'-nucleotidase / 遺伝子発現 / 超音波 / Ultrasound / 慢性心不全 / Ecto-5'-Nucleotidase / KATPチャネル / P70S6キナーゼ / P38MAPK / プレコンディショニング / 多施設臨床試験 / KATPチャネル開口剤 / KATP Channels / P70S6 Kinase / P38 MAP Kinase / Preconditioning / PKA / J-WIND / 5F-BAPTA / Doppler echocardiography / coronary circulation / micro circulation / cardiomyopa thy / 培養血管内皮細胞 / 酸化的ストレス / デジタル・サブトラクション・エコグラフィー / 左室壁運動異常 / 心蔵超音波 / デジタルサブトラクションエコグラフィ- / 左心室壁運動異常 / 動脈硬化症 / cardiomyocytes / mechanical stress / signal transduction / calcium ion / adrenomedulin / endothelin / Angiotensin II / G protein / 細胞内情報伝達 / エンドセリン / アンジオテンシンII / アドレノメデュリン / ANP / BNP / 心塞瘤 / リモデリング / コラーゲン代謝 / プロコラーゲンタイプIIIペプチド / 培養 / 細胞障害 / 環境因子 / 形態的指標 / 機能的指標 / 強磁場 / 超音波ドプラ法 / マイクロフィラメント / 高脂血症 / 内膜病変 / endothelial cells / hypercholesterolemia / Atherosclerosis / Doppler Velocimeter / Endothelial Cells / Microfilaments / Hypercholesterolemia / Intimal Lesions / 接着分子 / カルシウムシグナリング / 心筋細胞障害 / 再灌流 / 低分子量G蛋白質 / 介在板 / ギャップ結合 / 病態生理学 / ホスホランバン / カルシウムポンプ / アラキドン酸 / カルシウム遊離チャネル / Adhesion molecule / Calcium signaling / Myocardial injury / Heart failure / Low molecuar weight G-protein / Intercalated disc / Gap junction / 低酸素 / a1-アンドレナリン刺激 / 虚血耐性 / マンガンスーパーオキシドジスムターゼ / アンセチンスオリゴヌクレオチド / α1‐アドレナリン刺激 / アンチセンスオリゴヌクレオチド / hypoxia / alpha adrenergic stimulation / tolerance to ischemia / antisense oligodeoxyribonucleotides / ischemic preconditioning / 5′-nucleotidase / α_1アドレナリン受容体 / 虚血・再潅流障害 / adenosine. / ischemic preconditioning. / alpha1-adrenoceptor. / 画像解析 / カルシウム / 内皮細胞 / 混合培養 / フォトン / Cardiac myocyte / gene expression / image analysis / calcium / ATP感受性カリウムチャネル / 心臓 / 平滑筋 / クローニング / スルフォニル尿素受容体 / カリウムチャネルオープナ- / 培養細胞 / スルフオニル尿素受容体 / カリウム / チャネル / ATP感受性チャネル / スルフォニルウレア / cDNA / パッチクランプ / K_<ATP>チャネル / NDP / G蛋白 / ATP-sensitive potassium channels / heart / smooth muscle / cloning / sulfonylurea receptor / K^+ channel opener / culture cell / 心筋 / 組織性状診断 / Myocardium / Tissue characterization / 再潅流障害 / 一酸化窒素 / アンジオテンシン / アンジオテンシン変換酵素阻害薬 / レニン-アンジオテンシン系 / ACE活性 / ACE阻害薬 / reperfusion injury / nitric oxide / angiotensin, angiotensin converting enzyme inhibitor / 弗素化合物 / 循環 / 造影剤 / 気泡 / Ischemic Heart Disease / Circulation / Contrast / Perfusion / ecto-5'-nuclotidase / DNAmicroarray / アデノシン受容体遮断薬 / ecto-5' nucleotidase / アデノシン産生増強薬 / 左室駆出率 / 運動耐容能 / ccto-5´-nuclcotidase / 遺伝子発現ラット / Acute Myocardial Infarction / cDNA array / Adenosine Receptor Antagonists / Chronic Heart Failure / スタニング / 心筋保護 / アデノシン産生酵素 / カテコラミン / トランスジェニックマウス / 臨床試験 / 虚血・再潅流 / ccto-5^I-nuclcotidasc / 遺伝子導入 / prcconditioning現象 / protcin kinascC / Myocardial Infarction / Stunning / Cardioprotection / Cathecolamine / Clinical Trial / 運動療法 / 心筋症ハムスターBIO14.6 / 長期生命予後 / 心筋症ハムスター / 6-blocker療法 / 運動負荷試験 / 生命予後 / 運動耐溶能 / 心筋症ハムスタ- / exercise training / chronic heart failure / long term survival / Cardiomyopathic BIO 14.6 Syrian hamster / 拡張不全 / 高血圧 / 線維化 / レニン・アンジオテンシン系 / isolated diastolic heart failure / hypertension / hypertrophy / fibrosis / renin-angiotensin system / cDNAマイクロアレイ / ベットサイドウエルネスシステム / 仮想環境 / 運動負荷 / 自律神経 / バーチャルリアリティー / バーチャルリアリティ / the bedside wellness system / virtual reality / exercise test / autonomic function / 一酸化窒素(NO) / Rhoキナーゼ / プロテインキナーゼC / プロテインキナーゼA / J-WIND試験 / 心保護作用 / p38MAPキナーゼ / HSP27 / 増殖因子 / 創薬 / 興奮収縮連関 / 強心剤 / ゼブラフィッシュ / Heart Failure / Growth Factor / drug discovery / contraction-excitation coupling / cardiotonic drug / zebrafish / ユビキチン / プロテアソーム / アポトーシス / 小胞体ストレス / ubiquitin / proteasome / heart failure / apoptosis / ER stress / すり応力 / 超音波ドプラー法 / マイクロフィラメント束 / Shear stress / Endothelial cells / Microfilament bundles / 虚血 / 再灌流障害 / 摘出灌流心 / 細胞内カルシウム濃度 / フッ素核磁気共鳴法 / カルシウム・オ-バ-ロ-ド / 5FーBAPTA / 摘出灌流心標本 / カルシウム・オーバーロード / Ischemia / Isolated, perfused heart / Intracellular free Ca^<2+> / Fluorine Nuclear Magnetic Resonance / Calcium Overload Less

Development of Single Nucleotide Polymorphism Based Tailor Made Therapy in Patients with Acute Myocardial InfarctionPrincipal Investigator
- Principal Investigator
  
  SATO Hiroshi, 堀正二
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
New therapeutic approach for heart failure using HB-EGF mediated signal transduction
- Principal Investigator
  
  TAKASHIMA Seiji
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
The role of ER stress and ubiquitin-proteasome system in the development of heart failrue
- Principal Investigator
  
  MINAMINO Tetsuo
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
Experimental and clinical evaluation of cardioprotective effects by adenosine and nitric oxidePrincipal Investigator
- Principal Investigator
  
  HORIO Masatsugu
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
心不全治療の新しい標的としての増殖因子HB-EGFPrincipal Investigator
- Principal Investigator
  
  堀正二
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
The Identification of Cardioprotective Mechanism Afforded by Ischemic Preconditioning and its Application to the Therapy Against Acute Myocardial Infarction
- Principal Investigator
  
  SATO Hiroshi, 佐藤秀幸
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
Acquirement of the Ischemic Cardioprotection and ecto-5'-nucleotidase : Investigation of the Receptor Activation and Subsequent Signal Transduction
- Principal Investigator
  
  MASUYAMA Tohru, 北風政史
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
The effect of bedside wellness system on the autonomic, hormonal function and exercise tolerance in healthy subjects
- Principal Investigator
  
  SATO Hiroshi
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
Cardiac stress-responsive mechanism and its theraprutic applicationPrincipal Investigator
- Principal Investigator
  
  HORI Masatsugu
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (A).
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
Molecular epidemiology of acute coronary syndrome in Japan : Large-scale, prospective, multicenter clinical investigationPrincipal Investigator
- Principal Investigator
  
  HORI Masatsugu
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for University and Society Collaboration
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
Development and Establishment of a New Therapeutic Strategy for Chronic Heart Failure due to Adenosine.
- Principal Investigator
  
  KITAKAZE Masafumi
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
Prevention of atherosclerotic plaque rupture by the regulation of oxygen radical metabolism of vascular wall cells.Principal Investigator
- Principal Investigator
  
  HORI Masatsugu
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
Molcular Mechanisms and Clinical Role of the Phosphorylation and Activation of Ecto-5'-Nucleotidase, Adenosine Producing Enzyme in Cardioprotection.
- Principal Investigator
  
  KITAKAZE Masafumi
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
Effects of exercise trainig and long-Term Survival in the BIO 14.6 cardiomyopathic Hamsters with chronic heart failure.
- Principal Investigator
  
  SATO Hideyuki
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
Examination of the mechanism of the transition to isolated diastolic heart failure
- Principal Investigator
  
  MASUYAMA Tohru
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
Efficacy of Intravenous Ultrasonic Contrast Agent for Diagnosing Ischemic Heart Disease.
- Principal Investigator
  
  BEPPU Shintaro
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
Role of atherosclerosis on myocardial infarction -cross talk of renine-angiotensis system and nitric oxide-
- Principal Investigator
  
  NISHIDA Masashi, 星田四郎
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
The pathophysiological significanse and mechanism of activation of key enzyme responsible for adenosine production in ischemic preconditioning.Principal Investigator
- Principal Investigator
  
  HORI Masatsugu
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
Development of real-time two-dimensional ultrasonic myocardial tissue characterization to assess myocardial molecular characteristics.
- Principal Investigator
  
  TAKEDA Hiroshi, 井上通敏
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
Development of in vitro reconstituted system for investigating intracellular signal trasduction and cellular function in myocardial cellsPrincipal Investigator
- Principal Investigator
  
  HORI Masatsugu
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
心筋細胞の刺激受容機構とシグナル伝達系
- Principal Investigator
  
  矢崎義雄
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
急性心筋梗塞後の治癒過程と左室リモデリング-血中プロコラーゲンタイプIIIペプチドの意義-
- Principal Investigator
  
  KORETSUNE Yukihiro
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
Molecular cloning of ATP-sensitive K^+ channels and development of the method evaluating K^+ channel openers.
- Principal Investigator
  
  KURACHI Yoshihisa
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
Role of Calcium Signaling Pathway for Cardiac Cell Injury
- Principal Investigator
  
  TADA Michihiko
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
The Mechanism of the acquisition of tolerance to cardiac ischemia - the role of oxygen radical scavengers -
- Principal Investigator
  
  KUZUYA Tsunehiko
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
Cardioprotective effect of adenosine in ischemia and reperfusion injury
- Principal Investigator
  
  INOUE Michitoshi
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
Development of image analyze systems of gene expression in co-cultured cells
- Principal Investigator
  
  KUZUYA Tsunehiko
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
Role of calcium overload on coronary arterial stunning caused by myocardial ischemia reperfusionPrincipal Investigator
- Principal Investigator
  
  HORI Masatsugu
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
培養内皮細胞を用いた動脈硬化発症・進展における血流の関与の解明
- Principal Investigator
  
  田内潤
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
超音波断層法の変位検出能と超高精度化する高速度超音波基分法(HsDSE)の開発
- Principal Investigator
  
  田内潤
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (A)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
Cardioprotective roles of adenosine against ischemic and reperfusion injuryPrincipal Investigator
- Principal Investigator
  
  HORI Masatsugu
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
高速フ-リエ変換・ドプラ-カテ-テルによる不全心の冠血流・微小循環障害の解析
- Principal Investigator
  
  TANOUCHI Jun
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
A Study on the Interrelations of the Hemodynamics and the Vascualr Endothelial Ultrastructure and Function
- Principal Investigator
  
  INOUE Michitoshi
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
Role of Adrenergic Activity, Alpha-Receptor, and Beta-Receptor in Progression of Chronic Heart FailurePrincipal Investigator
- Principal Investigator
  
  HORI Masatsugu
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University, School of Medicine
A study on the dynamics of intracellular calcium ion in myocardium of isolated, perfused hearts during ischemia and after reperfusion.
- Principal Investigator
  
  KUSUOKA Hideo
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
Role of Neurohumoral Abnormalities and -Adrenergic Reeptor Changes in Progression of Chronic Heart FailurePrincipal Investigator
- Principal Investigator
  
  HORI Masatsugu
- Project Period (FY)
  1987 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
培養心筋細胞による各種環境要因の生体影響評価モデルの開発研究
- Principal Investigator
  
  武田裕
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for Environmental Science
- Research Institution
  Osaka University
Relation between wall shear stress in vivo and microfilament buncles in vascular endothelial cells.
- Principal Investigator
  
  KITABATAKE Akira
- Project Period (FY)
  1986 – 1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University

All 2009 2008 2007 2006 2005 2004 Other

All Journal Article Book Patent

[Book] 循環器疾患最新の治療2008
- Author(s)
  堀正二
- Total Pages
  561
- Publisher
  南江堂
- Data Source
  KAKENHI-PROJECT-19390215
[Book]
- Author(s)
  堀正二 : 循環器疾患最新の治療.南江堂2008年総561頁
- Data Source
  KAKENHI-PROJECT-19390215
[Journal Article] SNPs in BRAP associated with risk of myocardial infarction in Asian populations2009
- Author(s)
  Ozaki K, Sato H, Inoue K, Tsunoda T, Sakata Y, Mizuno H, Lin TH, Miyamoto Y, Aoki A, Onouchi Y, Sheu SH, Ikegawa S, Odashiro K, Nobuyoshi M, Juo SH, Hori M, Nakamura Y, Tanaka T.
- Journal Title
  
  Nat Genet 41(3)(Epub)
  
  Pages: 329-33
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390215
[Journal Article] Lymphotoxin-alpha3 mediates monocyte-endothelial interaction by TNFR I/NF-kappaB signaling2009
- Author(s)
  Suna S, Sakata Y, Shimizu M, Nakatani D, Usami M, Matsumoto S, Mizuno H, Ozaki K, Takashima S, Takeda H, Tanaka T, Hori M, Sato H.
- Journal Title
  
  Biochem Biophys Res Commun 379(2)(Epub)
  
  Pages: 374-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390215
[Journal Article] Impact of Diabetes Mellitus on Rehospitalization for Heart Failure Among Survivors of Acute Myocardial Infarction in the Percutaneous Coronary Intervention Era2009
- Author(s)
  Nakatani D, Sakata Y, Mizuno H, Shimizu M, Suna S, Usami M, Ito H, Yasumura Y, Hirayama A, Takeda H, Hori M, Sato H
- Journal Title
  
  the Osaka Acute Coronary Insufficiency Study (OACIS) Group. Circ J. 73(4)(Epub)
  
  Pages: 662-666
- NAID
  10025929227
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390215
[Journal Article] Up-regulation of cell adhesion molecule genes in human endothelial cells stimulated by lymphotoxin alpha : DNA microarray analysis2008
- Author(s)
  Suna S, Sakata Y, Sato H, Mizuno H, Nakatani D, Shimizu M, Usami M, Takashima S, Takeda H, Hori M. J
- Journal Title
  
  Atheroscler Thromb 15(3)
  
  Pages: 160-5
- NAID
  10022608417
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390215
[Journal Article] Effect of early use of low-dose pravastatin on major adverse cardiac events in patients with acute myocardial infarction : the OACIS-LIPID Study2008
- Author(s)
  Study. Sato H, Kinjo K, Ito H, Hirayama A, Nanto S, Fukunami M, Nishino M, Lim YJ, Kijima Y, Koretsune Y, Nakatani D, Mizuno H, Shimizu M, Hori M
- Journal Title
  
  M ; Osaka Acute Coronary Insufficiency Study (OACIS)-LIPID Study Investigators. Circ J. 72(1)
  
  Pages: 17-22
- NAID
  110006533907
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390215
[Journal Article] Effect of intracoronary thrombectomy on 30-day mortality in patients with acute myocardial infarction2007
- Author(s)
  Nakatani D, Sato H, Sakata Y, Mizuno H, Shimizu M, Suna S, Nanto S, Hirayama A, Ito H, Fujii K, Hori M.
- Journal Title
  
  Am J Cardiol 100(8)(Epub)
  
  Pages: 1212-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390215
[Journal Article] A Novel Cardiac Myosin Light Chain Kinase Regulates Sarcomere Assembly in the Vertebrate Heart.2007
- Author(s)
  Osamu Seguchi, Seiji Takashima, Satoru Yamazaki, Masanori Asakura, Yoshihiro Asano, Yasunori Shintani, Masakatsu Wakeno, Tetsuo Minamino, Hiroya Kondo, Hidehiko Furukawa, Kenji Nakamaru, Asuka NaitoTomoko Takahashi, Toshiaki Ohtsuka, Koichi Kawakami, Tadashi Isomura, Soichiro Kitamura, Hitonobu Tomoike, Naoki Mochizuki, Masafumi Kitakaze
- Journal Title
  
  J. of Clin.Invest. (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390229
[Journal Article] Prolonged transient acidosis during early reperfusion contributes to the cardioprotective effects of postconditioning.2007
- Author(s)
  Fujita M, Asanuma H, Hirata A, Wakeno M, Takahama H, Sasaki H, Kim J, Takashima S, Tsukamoto O, Minamino T, Shinozaki Y, Tomoike H, Hori M, Kitakaze M.
- Journal Title
  
  Am J Physiol Heart Circ Physiol. 292(4)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590731
[Journal Article] S-nitrosylated and pegylated hemoglobin, a newly developed artificial oxygen carrier, exerts cardioprotection against ischemic hearts.2007
- Author(s)
  Asanuma H, Nakai K, Sanada S, Minamino T, Takashima S, Ogita H, Fujita M, Hirata A, Wakeno M, Takahama H, Kim J, Asakura M, Sakuma I, Kitabatake A, Hori M, Komamura K, Kitakaze M.
- Journal Title
  
  J Mol Cell Cardiol. (In press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590731
[Journal Article] A functional SNP in ITIH3 is associated with susceptibility to myocardial infarction2007
- Author(s)
  Ebana Y, Ozaki K, Inoue K, Sato H, Iida A, Lwin H, Saito S, Mizuno H, Takahashi A, Nakamura T, Miyamoto Y, Ikegawa S, Odashiro K, Nobuyoshi M, Kamatani N, Hori M, Isobe M, Nakamura Y, Tanaka T.
- Journal Title
  
  J Hum Genet 52(3)(Epub)
  
  Pages: 220-9
- NAID
  10018554093
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390215
[Journal Article] Effect on outcome of an increase of serum cardiac troponin T in patients with healing or healed ST-elevation myocardial infarction2007
- Author(s)
  Shimizu M, Sato H, Sakata Y, Nakatani D, Mizuno H, Suna S, Fujii K, Ueda Y, Nanto S, Hori M
- Journal Title
  
  Osaka Acute Coronary Insufficiency Study (OACIS) Group. Am J Cardiol 100(12)(Epub)
  
  Pages: 1723-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390215
[Journal Article] Clinical impact of metabolic syndrome and its additive effect with smoking on subsequent cardiac events after acute myocardial infarction2007
- Author(s)
  Nakatani D, Sakata Y, Sato H, Mizuno H, Shimizu M, Suna S, Ito H, Koretsune Y, Hirayama A, Hori M
- Journal Title
  
  Osaka Acute Coronary Insufficiency Study (OACIS) Group. Am J Cardiol 99(7)(Epub)
  
  Pages: 885-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390215
[Journal Article] Erythropoietin enhances neovascularization of ischemic myocardium and improves left ventricular dysfunction after myocardial infarction in dogs.2006
- Author(s)
  Hirata A, Minamino T, Asanuma H, Fujita M, Wakeno M, Myoishi M, Tsukamoto O, Okada K, Koyama H, Komamura K, Takashima S, Shinozaki Y, Mori H, Shiraga M, Kitakaze M, Hori M.
- Journal Title
  
  J Am Coll Cardiol. 48(1)
  
  Pages: 176-84
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590731
[Journal Article] The antagonism of aldosterone receptor prevents the development of hypertensive heart failure induced by chronic inhibition of nitric oxide synthesis in rats.2006
- Author(s)
  Tsukamoto, O., Minamino, T., Sanada, S., Okada, K., Hirata, A., Fujita, M., Shintani, Y., Yulin, L., Asano, Y, Takashima, S., Yamasaki, S., Tomoike, H., Hori, M., Kitakaze, M.
- Journal Title
  
  Cardiovasc Drugs Ther 20
  
  Pages: 93-102
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390229
[Journal Article] Glycosaminoglycan modification of neuropilin-1 modulates VEGFR2 signaling.2006
- Author(s)
  Shintani, Y., Takashima, S., Asano, Y., Kato, H., Liao, Y., Yamazaki, S., Tsukamoto, 0., Seguchi, O., Yamamoto, H., Fukushima, T., Sugahara, K., Kitakaze, M., Hori, M.
- Journal Title
  
  Embo J 25
  
  Pages: 3045-55
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390229
[Journal Article] A calcium channel blocker amlodipine ircreases coronary blood flow via both adenosine- and NO-dependent mechanisms in ischemic hearts.2005
- Author(s)
  Asanuma Hiroshi
- Journal Title
  
  J Mol Cell Cardiol 39
  
  Pages: 605-614
- Data Source
  KAKENHI-PROJECT-17590731
[Journal Article] A calcium channel blocker amlodipine increases coronary blood flow via both adenosine-and NO-dependent mechanisms in ischemic hearts.2005
- Author(s)
  Asanuma Hiroshi
- Journal Title
  
  J Mol Cell Cardiol 39
  
  Pages: 605-614
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390225
[Journal Article] Beta-adrenoceptor blocker carvedilol provides cardioprotection via an adenosine-dependent mechanism in ischemic canine hearts.2004
- Author(s)
  Asanuma Hiroshi
- Journal Title
  
  Circulation 109
  
  Pages: 2773-2779
- Data Source
  KAKENHI-PROJECT-16390225
[Journal Article] Methotrexate and MX-68, a new derivative of methotrexate, limit infarct size via adenosine-dependent mechanisms in canine hearts.2004
- Author(s)
  Asanuma Hiroshi
- Journal Title
  
  J Cardiovasc Pharmacol 43
  
  Pages: 574-579
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390225
[Journal Article] Methotrexate and MX-68, a new derivative of methotrexate, limit infarct size via adenosine-dependent mechanisms in canine hearts2004
- Author(s)
  Asanuma Hiroshi
- Journal Title
  
  J Cardiovasc Pharmacol 43
  
  Pages: 574-579
- Data Source
  KAKENHI-PROJECT-16390225
[Journal Article] Beta-adrenoceptor blocker carvedilol provides cardioprotection via an adenosine- dependent mechanism in ischemic canine hearts.2004
- Author(s)
  Asanuma Hiroshi
- Journal Title
  
  Circulation 109
  
  Pages: 2773-2779
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390225
[Journal Article] Beta-adrenoceptor blocker carvedilol provides cardioprotection via an adenosine-dependent mechanism in ischemiccaninehearts.2004
- Author(s)
  Asanuma Hiroshi
- Journal Title
  
  Circulation 109
  
  Pages: 2773-2779
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390225
[Patent] 心不全の判定方法2006
- Inventor(s)
  南野哲男, 堀正二, 岡田健一郎, 北風政史
- Industrial Property Rights Holder
  国立大学法人大阪大学, 財団法人ヒューマンサイエンス振興財団
- Industrial Property Number
  2006-016514
- Filing Date
  2006-01-25
- Data Source
  KAKENHI-PROJECT-17590731

1. KUZUYA Tsunehiko (80150340)

# of Collaborated Projects: 15 results

# of Collaborated Products: 0 results
2. KITAKAZE Masafumi (20294069)

# of Collaborated Projects: 14 results

# of Collaborated Products: 6 results
3. INOUE Michitoshi (30028401)

# of Collaborated Projects: 11 results

# of Collaborated Products: 0 results
4. SATO Hiroshi (10294092)

# of Collaborated Projects: 11 results

# of Collaborated Products: 9 results
5. SATO Hideyuki (70167435)

# of Collaborated Projects: 9 results

# of Collaborated Products: 0 results
6. TADA Michihiko (90093434)

# of Collaborated Projects: 8 results

# of Collaborated Products: 0 results
7. MASUYAMA Tohru (70273670)

# of Collaborated Projects: 8 results

# of Collaborated Products: 0 results
8. TAKEDA Hiroshi (20127252)

# of Collaborated Projects: 8 results

# of Collaborated Products: 0 results
9. NISHIDA Masashi (40283783)

# of Collaborated Projects: 7 results

# of Collaborated Products: 0 results
10. KORETSUNE Yukihiro (50243217)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
11. TANOUCHI Jun (20197544)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
12. KITABATAKE Akira (00124769)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
13. HOSHIDA Shiro (80238732)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
14. TAKASHIMA Seiji (90379272)

# of Collaborated Projects: 4 results

# of Collaborated Products: 6 results
15. MIYAZAKI Jun-ichi (10200156)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
16. MINAMINO Tetsuo (30379234)

# of Collaborated Projects: 4 results

# of Collaborated Products: 5 results
17. TOYOFUKU Toshihiko (60322179)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
18. KUSUOKA Hideo (00112011)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
19. OHTSU Kin-ya (20294051)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
20. CHIHARA Kunihiro (80029561)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
21. BEPPU Shintaro (40113500)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
22. MATSUMURA Yasushi (90252642)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
23. ISHIHARA Ken (20304610)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
24. 近藤寛也 (40294102)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
25. UEMATSU Masaaki

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
26. SAKATA Yasuhiko (90379206)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
27. ENDO Masao (40004668)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. TSUKITA Shoichiro (50155347)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. TOYAMA Junji (20023658)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. KURACHI Yoshihisa (30142011)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. YAMADA Mitsuhiko (10263237)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. TAKUMI Toru (00222092)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. FUJIWARA Keigi (10190092)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
34. YONEDA Yoshihiro (80191667)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
35. ISHIKURA Fuminobu (50303970)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
36. YAMAMOTO Kazuhiro (90303966)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
37. MIWA Takeshi (20174229)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
38. ONISHI Shunzo (00028367)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
39. 鎌田武信 (80028399)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
40. 矢崎義雄 (20101090)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
41. 寒川賢治 (00112417)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
42. 高井義美 (60093514)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
43. 横山光宏 (40135794)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
44. 篠山重威 (70109007)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
45. 島津敬 (50178935)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
46. 中馬一郎 (10028269)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
47. 堀尾嘉幸 (30181530)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
48. 高橋尚彦 (30263239)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
49. FUJIMOTO Masao

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
50. KURIHARA Toshinao

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
51. YAMASHITA Nobushige

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
52. DOI Reiko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
53. 鍵谷俊文

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
54. 藤井謙司

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
55. FUJII Kenshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

HORIO Masatsugu 堀 正二

HORI Masatsugu 堀 正二

Research Projects

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Co-Researchers

Development of Single Nucleotide Polymorphism Based Tailor Made Therapy in Patients with Acute Myocardial InfarctionPrincipal Investigator

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Experimental and clinical evaluation of cardioprotective effects by adenosine and nitric oxidePrincipal Investigator

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心不全治療の新しい標的としての増殖因子HB-EGFPrincipal Investigator

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Cardiac stress-responsive mechanism and its theraprutic applicationPrincipal Investigator

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Molecular epidemiology of acute coronary syndrome in Japan : Large-scale, prospective, multicenter clinical investigationPrincipal Investigator

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Prevention of atherosclerotic plaque rupture by the regulation of oxygen radical metabolism of vascular wall cells.Principal Investigator

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HORIO Masatsugu 堀正二

HORI Masatsugu 堀正二