Higashi Shoichi 東昌市

… Alternative Names

Higashi Shouichi 東昌市

HIGASHI Shouichi 東昌市

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Researcher Number	10275076
Other IDs
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Affiliation (Current)	2025: 横浜市立大学, 生命ナノシステム科学研究科(八景キャンパス), 教授
Affiliation (based on the past Project Information) *help	2019 – 2023: 横浜市立大学, 生命ナノシステム科学研究科(八景キャンパス), 教授 2016 – 2017: 横浜市立大学, 生命ナノシステム科学研究科(八景キャンパス), 教授 2016: 横浜市立大学, 大学院生命ナノシステム科学研究科, 教授 2015: 横浜市立大学, 生命ナノシステム科学研究科, 教授 2013 – 2014: 横浜市立大学, 生命ナノシステム科学研究科, 准教授 … More 2013: 横浜市立大学, 大学院・生命ナノシステム科学研究科, 准教授 2010 – 2011: 横浜市立大学, 大学院・生命ナノシステム科学研究科, 准教授 2009 – 2011: Yokohama City University, 生命ナノシステム科学研究科, 准教授 2007: 横浜市立大学, 木原生物学研究所, 助教 2006: 横浜市立大学, 助手 1996 – 2006: 横浜市立大学, 木原生物学研究所, 助手 1993: Faculty of Science, Kyushu University JSPS Fellowships for Japanese Junior Scien, 理学部, 日本学術振興会特別研 Less
Review Section/Research Field	Principal Investigator Structural biochemistry / Structural biochemistry / Basic Section 47030:Pharmaceutical hygiene and biochemistry-related / Biomedical engineering/Biomaterial science and engineering / Functional biochemistry Except Principal Investigator Biological Sciences / Tumor biology / Biomedical engineering/Biological material science / 広領域 / Tumor biology
Keywords	Principal Investigator MMP-7 / マトリックスメタロプロテアーゼ / コレステロール硫酸 / がん転移 / 細胞間接着 / HAI-1 / 細胞凝集 / ゼラチナーゼA / 細胞表層プロテオリシス / MMP-2 … More / MT1-MMP / プロテアーゼインヒビター / アミロイド前駆体タンパク質 / プロテアーゼ / 細胞膜ラフト / ダイナミン / 活性型コンフォーメーション / セリンプロテアーゼ / CRISPR-Cas9 / エンドサイトーシス / マトリプターゼ / 再生医療 / 転移 / 大腸がん / オリゴペプチド / PKDドメイン / がん転移抑制剤 / ペプチドインヒビター / 高特異性インヒビター / TIMP / MMP / TIMP-1 / MMP-9 / APP-IP / selective inhibitor / matrix metalloproteinase / 血栓症 / 血小板凝集 / TIMP-2 / β-アミロイド前駆体タンパク / 癌の浸潤・転移 / 基質特異性変化 / fibronectin / laminin-332 / がんの浸潤・転移 / 高選択性阻害剤 / 酵素活性阻害機構 / タンパク質結晶構造解析 / MMPインヒビター / β-アミロイド前駆体タンパク質 / 分子認識及び相互作用 / 細胞表層タンパク質 / β-シクロデキストリン / 癌転移 / 酸性脂質 / マトリライシン / プロセッシング / アミロイド前躯体タンパク質 / マトリックスメタプロテアーゼ / プロセシング / MT-MMP / アミロイド前駆体蛋白質 / βアミロイド蛋白質 / アルツハイマー痴呆症 … More Except Principal Investigator 細胞接着 / 細胞外マトリックス / ラミニン / がん浸潤 / 浸潤 / 細胞接着分子 / ラミニン5 / MMP / basement membrane / cell adhesion / Gla-EGF1 / がん幹細胞 / CD44 / ラミニンγ2 / 細胞移動 / 浸潤・転移 / 基底膜 / 血管内皮細胞 / マトリライシン / 腫瘍増殖 / がん転移 / プロテアーゼ / MT-MMP / がんマーカー / モノクローナル抗体 / 病理診断 / 免疫染色 / がん微小環境 / vascular endothelial cell / differentiation / proliferation / mesenchymal stem cell / stem cell / laminin / 細胞培養 / 軟骨 / 間質系幹細胞 / 再生医療 / 分化 / 増殖 / 間葉系幹細胞 / 幹細胞 / tumor invasion / processing / globular domain / cell motility / laminin-4 / 癌 / ドメイン構造 / 細胞運動 / インテグリン / VII-TF molecular complex / Factor IX / Factor VIIa / Gla-domain / Extrinsic blood coagulation / Tissue factor / Factor VII / セレクチン / 外因系凝固反応 / 血液凝固因子 / EGF様ドメイン / 外因系血液凝固反応 / Gla-EGF-1 / VII-TF分子複合体 / IX因子 / VIIa因子 / Glaドメイン / 血液凝固反応 / 組織因子 / VII因子 / 腹水 / 浮遊増殖 / がんの浸潤 / コラーゲンマトリックス / 微小管 / 浸潤モデル / 浮遊性増殖 / TGF-β / EMT / 線維芽細胞 / TGF-beta / HGF / コラーゲンゲル / がん浸潤モデル / 腫瘍-間質相互作用 / 腫瘍血管 / 上皮間葉変換（EMT） / ラミニン332 / マトリプターゼ / 阻害剤 / がん / 上皮-間葉変換(EMT) / 転移 / カドヘリン / 血管新生 / 大腸がん / がん細胞 / MMP-7 / メタロプロテアーゼ / ラミニン6 / MT1-MMP / APP / ゼラチナーゼ / プロセシング / アミロイド蛋白質 / 蛋白質分解酵素 / 動脈硬化 / アルツハイマー病 / マトリックスメタロプロテアーゼ Less

Studies on mechanism of inter cellular adhesion induced by cleavage of cancer cell surface HAI-1 protein and following enhancement of cancer metastasis.Principal Investigator
- Principal Investigator
  
  Higashi Shouichi
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Yokohama City University
Molecular mechanism of MMP-7-enhanced liver metastasis of colon cancer, and its application for liver regenerative medicinePrincipal Investigator
- Principal Investigator
  
  Higashi Shouichi
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Biomedical engineering/Biomaterial science and engineering
- Research Institution
  Yokohama City University
Roles of tumor invasion marker laminin gamma2 chain in tumor progression and cancer stem cell functions
- Principal Investigator
  
  MIYAZAKI KAORU
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor biology
- Research Institution
  Kanagawa Cancer Center Research Institute
Design of highly selective MMP inhibitors by coupling selective peptide inhibitors with physiological MMP-binding proteinsPrincipal Investigator
- Principal Investigator
  
  Higashi Shouichi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  Yokohama City University
Disorder of cell adhesion system in tumor progression
- Principal Investigator
  
  MIYAZAKI KAORU
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Tumor biology
- Research Institution
  Yokohama City University
Development of highly selective inhibitors against individual MMPsPrincipal Investigator
- Principal Investigator
  
  HIGASHI Shouichi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  Yokohama City University
Interaction of cancer cells with basement membrane proteins
- Principal Investigator
  
  MIYAZAKI Kaoru
- Project Period (FY)
  2005 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Yokohama City University
Application of a new cell-adhesive and cell-migatory molecule, laminin-5B, to regenerative medicine
- Principal Investigator
  
  MIYAZAKI Kaoru
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Yokohama City University
癌細胞表層に存在するMMP-7機能変換分子の同定とその癌転移促進機構の解析Principal Investigator
- Principal Investigator
  
  東昌市
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  Yokohama City University
マトリックスプロテアーゼによるがん細胞の機能制御
- Principal Investigator
  
  宮崎香
- Project Period (FY)
  2001 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Yokohama City University
アミロイド前駆体タンパク質によるMMP活性調節機構の解析Principal Investigator
- Principal Investigator
  
  東昌市
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  Yokohama City University
Structure and Function of Laminin-5, a Cell Adhesion Protein of Basement Membrane
- Principal Investigator
  
  MIYAZAKI Kaoru
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  広領域
- Research Institution
  Yokohama City University
アミロイド前駆体タンパク質の細胞外放出機構の解析およびその生理的意義の解明Principal Investigator
- Principal Investigator
  
  東昌市
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Functional biochemistry
- Research Institution
  Yokohama City University
マトリックスメタロプロテアーゼのアルツハイマー病および動脈硬化における関与
- Principal Investigator
  
  MIYAZAKI Kaoru
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Yokohama City University
ゼラチナーゼAの活性発現・制御機構の解析Principal Investigator
- Principal Investigator
  
  東昌市
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Structural biochemistry
- Research Institution
  Yokohama City University
Molecular Mechanism of Extrinsic Blood Coagulation Pathway
- Principal Investigator
  
  IWANAGA Sadaaki
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Faculty of Science, Kyushu University

[Book] Proteases and Cancer: Methods and Protocols2024
- Author(s)
  Kazuhiro Yamamoto, Moe Isohata, Shouichi Higashi
- Total Pages
  316
- Publisher
  Springer
- ISBN
  9781071635889
- Data Source
  KAKENHI-PROJECT-19K07047
[Journal Article] Matrix metalloproteinase-7 induces homotypic tumor cell aggregation via proteolytic cleavage of the membrane-bound Kunitz-type inhibitor HAI-1.2017
- Author(s)
  Ishikawa T, Kimura Y, Hirano H, Higashi S
- Journal Title
  
  The Journal of Biological Chemistry
  
  Volume: 292 Issue: 50 Pages: 20769-20784
- DOI
  10.1074/jbc.m117.796789
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K12900, KAKENHI-PROJECT-16H05230
[Journal Article] Amino-terminal fragments of laminin γ2 chain stimulate migration of metastatic breast cancer cells by interacting with CD442015
- Author(s)
  Sato, H, Oyanagi, J., Komiya, E., Ogawa, T, Higashi, S., Miyazaki, K.
- Journal Title
  
  Clin. Exp. Metastasis
  
  Volume: 32 Issue: 5 Pages: 405-415
- DOI
  10.1007/s10585-015-9705-6
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26430119, KAKENHI-PROJECT-25440033
[Journal Article] Small-molecule auxin inhibitors that target YUCCA are powerful tools for studying auxin function.2015
- Author(s)
  Kakei Y, Yamazaki C, Suzuki M, Nakamura A, Sato A, Ishida Y, Kikuchi R, Higashi S, Kokudo Y, Ishii T, Soeno K, Shimada Y
- Journal Title
  
  Plant J
  
  Volume: 84 Issue: 4 Pages: 827-37
- DOI
  10.1111/tpj.13032
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25514004, KAKENHI-PROJECT-26450069, KAKENHI-PROJECT-26506015, KAKENHI-PROJECT-26506016, KAKENHI-PROJECT-25440033, KAKENHI-PROJECT-26450046
[Journal Article] Modulation of matrix metalloproteinase-9 secretion from tumor-associated macrophage-like cells by proteolytically processed laminin-332 (laminin-5)2014
- Author(s)
  Kamoshida, G., Ogawa, T., Oyanagi, J., Sato, H., Komiya, E., Higashi, S., Miyazaki, K., Tsuji, T.
- Journal Title
  
  Clin. Exp. Metastasis
  
  Volume: 31 Pages: 285-291
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26430119
[Journal Article] Angiomodulin (AGM/IGFBP-rP1) is a molecular marker of vascular endothelial cells activated by VEGF in human breast cancers.2014
- Author(s)
  Komiya, E, Sato, H., Ise, I., Watanabe, N., Higashi, H., Miyagi, Y., Miyazaki, K.
- Journal Title
  
  Cancer Med
  
  Volume: 印刷中 Issue: 3 Pages: 537-549
- DOI
  10.1002/cam4.216
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-23112517, KAKENHI-PROJECT-23300351, KAKENHI-PROJECT-24590499, KAKENHI-PROJECT-25440033, KAKENHI-PROJECT-26430119, KAKENHI-PROJECT-221S0001
[Journal Article] Inhibition of transforming growth factor-β signaling potentiates tumor cell invasion into collagen matrix induced by fibroblast-derived hepatocyte growth factor.2014
- Author(s)
  Oyanagi, J., Kojima, N., Sato, H., Higashi, S., Kikuchi, K., Sakai, K., Matsumoto, K., Miyazaki, K.
- Journal Title
  
  Exp Cell Res.
  
  Volume: 印刷中 Issue: 2 Pages: 267-279
- DOI
  10.1016/j.yexcr.2014.04.009
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-23112517, KAKENHI-PROJECT-23300351, KAKENHI-PROJECT-24300329, KAKENHI-PROJECT-25440033, KAKENHI-PROJECT-26430119
[Journal Article] Amino-terminal fragments of laminin gamma2 chain retract vascular endothelial cells and increase vascular permeability.2014
- Author(s)
  Sato, H, Oyanagi, J., Komiya, E., Ogawa, T, Higashi, S., Miyazaki, K.
- Journal Title
  
  Cancer Sci.
  
  Volume: 105 Issue: 2 Pages: 168-175
- DOI
  10.1111/cas.12323
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-23112517, KAKENHI-PROJECT-23300351, KAKENHI-PROJECT-25440033, KAKENHI-PROJECT-26430119
[Journal Article] Pericellular proteolysis by matrix metalloproteinase-7 is differentially modulated by cholesterol sulfate, sulfatide, and cardiolipin.2014
- Author(s)
  Kazuhiro Yamamoto, Kaoru Miyazaki, and Shouichi Higashi
- Journal Title
  
  FEBS J.
  
  Volume: 281 Issue: 15 Pages: 3346-3356
- DOI
  10.1111/febs.12865
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25440033
[Journal Article] Modulation of matrix metalloproteinase-9 secretion from tumor-associated macrophage-like cells by proteolytically processed laminin-332 (laminin-5).2014
- Author(s)
  Kamoshida, G., Ogawa, T., Oyanagi, J., Sato, H., Komiya, E., Higashi, S., Miyazaki, K., Tsuji, T.
- Journal Title
  
  Clin. Exp. Metastasis
  
  Volume: 31 Issue: 3 Pages: 285-291
- DOI
  10.1007/s10585-013-9627-0
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-23112517, KAKENHI-PROJECT-23300351, KAKENHI-PROJECT-23590092, KAKENHI-PROJECT-25440033, KAKENHI-PROJECT-25890019
[Journal Article] Molecular design of a highly selective and strong protein inhibitor against matrix metalloproteinase-2 (MMP-2)2013
- Author(s)
  Higashi, S., Hirose, T., Takeuchi, T., Miyazaki, K.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 288 Issue: 13 Pages: 9066-9076
- DOI
  10.1074/jbc.m112.441758
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-23112517, KAKENHI-PROJECT-23300351, KAKENHI-PROJECT-25440033
[Journal Article] Elevated expression of angiomodulin (AGM/GFBP-rP1) in tumor stroma and its roles in fibroblast activation2012
- Author(s)
  Eriko Komiya
- Journal Title
  
  Cancer Science
  
  Volume: 102 Issue: 4 Pages: 691-699
- DOI
  10.1111/j.1349-7006.2012.02203.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21570118, KAKENHI-PUBLICLY-23112517, KAKENHI-PROJECT-23300351
[Journal Article] Elevated expression of angiomodulin(AGM/IGFBP-rP1) in tumor stroma and its roles in fibroblast activation2012
- Author(s)
  Eriko Komiya, Momoko Furuya, Naoko Watanabe, Yohei Miyagi, Shouichi Higashi, Kaoru Miyazaki
- Journal Title
  
  Cancer Sci
  
  Volume: 103 Pages: 691-699
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21570118
[Journal Article] Epithelial-mesenchymal transition stimulates human cancer cells to extend microtubule-based invasive protrusions and suppresses cell growth in collagen gel2012
- Author(s)
  Oyanagi, J., Ogawa, T., Sato, H., Higashi, S., Miyazaki, K
- Journal Title
  
  PLoS ONE
  
  Volume: 7(12)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23300351
[Journal Article] Downregulation of a newly identified laminin, laminin-3B11, in vascular basement membranes of invasive human breast cancers2011
- Author(s)
  Taizo Mori, Yoshinobu Kariya, Eriko Komiya, Shouichi Higashi, Yohei Miyagi, Kiyotoshi Sekiguchi, and Kaoru Miyazaki
- Journal Title
  
  Cancer Sci
  
  Volume: 102 Pages: 1095-1100
- NAID
  10029293987
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21570118
[Journal Article] Down-regulation of a newly identified laminin, laminin-3B11, in vascular basement membranes of invasive human breast cancers.2011
- Author(s)
  Mori, T., Kariya, Y., Komiya, T., Higashi, S., Miyagi, Y., Sekiguchi, K., Miyazaki, K.
- Journal Title
  
  Cancer Sci. 102
  
  Pages: 1095-1100
- NAID
  10029293987
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014077
[Journal Article] Structural basis for matrix metalloproteinase-2 (MMP-2)-selective inhibitory action of beta-amyloid precursor protein-derived inhibitor2011
- Author(s)
  Hashimoto, H., Takeuchi, T., Komatsu, K., Miyazaki, K., Sato, M., Higashi, S
- Journal Title
  
  J. Biol. Chem
  
  Volume: 286 Pages: 33236-33243
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23300351
[Journal Article] Downregulation of a newly identified laminin, laminin-3B11, in vascular basement membranes of invasive human breast cancers2011
- Author(s)
  Mori, T., Miyazaki, K., et al
- Journal Title
  
  Cancer Sci.
  
  Volume: 102 Issue: 5 Pages: 1095-1100
- DOI
  10.1111/j.1349-7006.2011.01892.x
- NAID
  10029293987
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-23112517, KAKENHI-PROJECT-23300351
[Journal Article] Structural Basis for Matrix Metalloproteinase-2(MMP-2)-selective Inhibitory Action of・-Amyloid Precursor Protein-derived Inhibitor2011
- Author(s)
  Hiroshi Hashimoto, Tomoka Takeuchi, Kyoko Komatsu, Kaoru Miyazaki, Mamoru Sato, and Shouichi Higashi
- Journal Title
  
  J. Biol. Chem
  
  Volume: 286 Pages: 33236-33243
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21570118
[Journal Article] Laminin-3B11, a Novel Vascular-type Laminin Capable of Inducing Prominent Lamellipodial Protrusions in Microvascular Endothelial Cells2010
- Author(s)
  Taizo Mori, Kota Ono, Yoshinobu Kariya, Takashi Ogawa, Shouichi Higashi, and Kaoru Miyazaki
- Journal Title
  
  J. Biol. Chem
  
  Volume: 285 Pages: 35068-35078
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21570118
[Journal Article] Cholesterol Sulfate Alters Substrate Preference of Matrix Metalloproteinase-7 and Promotes Degradations of Pericellular Laminin-332 and Fibronectin2010
- Author(s)
  Kazuhiro Yamamoto, Kaoru Miyazaki, and Shouichi Higashi
- Journal Title
  
  J. Biol. Chem
  
  Volume: 285 Pages: 28862-28873
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21570118
[Journal Article] Laminin-3B11, a novel vascular type laminin capable of inducing prominent lamellipodial protrusions in microvascular endothelial cells.2010
- Author(s)
  Mori, T., Ono, K., Kariya, Y., Ogawa, T., Higashi, S., Miyazaki, K.
- Journal Title
  
  J.Biol.Chem. 285
  
  Pages: 35068-35078
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014077
[Journal Article] Cholesterol sulfate alters substrate preference of matrix metalloproteinase-7 and promotes degradations of pericellular laminin-332 and fibronectin.2010
- Author(s)
  Yamamoto, K., Miyazaki, K., Higashi, S.
- Journal Title
  
  J.Biol.Chem. 285
  
  Pages: 28862-28873
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014077
[Journal Article] Matrilysin Cleaves C-type Lectin Domain Family 3 Member A(CLEC3A) on Tumor Cell Surface and Modulates its Cell Adhesion Activity2009
- Author(s)
  Jun Tsunezumi, Shouichi Higashi and Kaoru Miyazaki
- Journal Title
  
  J. Cell Biochem
  
  Volume: 106 Pages: 693-70
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21570118
[Journal Article] Matrilysin (MMP-7) cleaves C-type lectin domain family 3 member A (CLEC3A) on tumor cell surface and modulates its cell adhesion activity2009
- Author(s)
  Tsunezumi, J., Higashi, H., Miyazaki, K
- Journal Title
  
  J. Cell. Biochem 106
  
  Pages: 693-702
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014077
[Journal Article] Matrilysin (MMP-7) cleaves C-type lectin domain family 3 member A (CLEC3A) on tumor cell surface and modulates its cell adhesion activity.2009
- Author(s)
  Tsunezumi, J., Higashi, S., Miyazaki, K.
- Journal Title
  
  J.Cell.Biochem. 106
  
  Pages: 693-702
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014077
[Journal Article] Matrilysin (matrix metallo- protease-7) cleaves membrane-bound annexin II and enhances binding of tissue-type plasminogen activator to cancer cell surfaces.2008
- Author(s)
  Tsunezumi J, Yamamoto K, Higashi S, Miyazaki K.
- Journal Title
  
  FEBS J. 275
  
  Pages: 4810-4823
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014077
[Journal Article] Identification of amino acid residues of matrix metallopro-teinase-2 essential for its selective inhibition by beta-amyloid precursor protein-derived inhibitor.2008
- Author(s)
  Higashi, S. Miyazaki, K.
- Journal Title
  
  J Biol Chem. 283
  
  Pages: 10068-10078
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014077
[Journal Article] Identification of amino acid residues of matrix metalloproteinase-7 essential for binding to cholesterol sulfate2008
- Author(s)
  Higashi, S., Oeda, M., Yamamoto, K. and Miyazaki, K
- Journal Title
  
  J Biol Chem 838
  
  Pages: 35735-35744
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014077
[Journal Article] Identification of amino acid residues of matrix metalloproteinase-2 essential for its selective inhibition by beta-amyloid precursor protein-derived inhibitor2008
- Author(s)
  Higashi, S. and Miyazaki, K
- Journal Title
  
  J Biol Chem 283
  
  Pages: 10068-10078
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014077
[Journal Article] Idenitification of amino acid residues of matrix metalloproteinase-2 essential for its selective inhibition by beta-amyloid precursor protein-derived inhibitor.2008
- Author(s)
  Higashi, S., Miyazaki, K.
- Journal Title
  
  J.Biol.Chem. 283
  
  Pages: 10068-10078
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014077
[Journal Article] Matrilysin (matrix metalloprotease-7) cleaves membrane-bound annexin II and enhances binding of tissue-type plasminogen activator to cancer cell surfaces2008
- Author(s)
  Tsunezumi J, Yamamoto K, Higashi S, Miyazaki K
- Journal Title
  
  FEBS J 275
  
  Pages: 4810-4823
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014077
[Journal Article] Identification of amino acid residues of matrix metalloproteinase-7 essential for binding to cholesterol sulfate.2008
- Author(s)
  Higashi, S., Oeda, M., Yamamoto, K., Miyazaki, K.
- Journal Title
  
  J.Biol.Chem. 283
  
  Pages: 35735-35744
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014077
[Journal Article] Matriptase activates stromelysin (MMP-3) and promotes tumor growth and angiogenesis.2006
- Author(s)
  Jin, X, J., Yagi, M., Akiyama, N., Hirosaki, T., Higashi, S., Lin, C-Y., Dickson, R.B., Kitamura, H., Miyazaki, K.
- Journal Title
  
  Cancer Sci. 97
  
  Pages: 1327-1334
- NAID
  10020387781
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014077
[Journal Article] Binding of active matrilysin to cell surface cholesterol sulfate is essential for its membrane-associated proteolytic action and induction of homotypic cell adhesion.2006
- Author(s)
  Yamamoto , K., Higashi, S., Kioi, M., Tsunezumi, J., Honke, K., Miyazaki, K.
- Journal Title
  
  J.Biol.Chem. 281
  
  Pages: 9170-9180
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014077
[Journal Article] Identification of membrane-bound serine proteinase matriptase as processing enzyme of insulin-like growth factor binding protein-related rrotein-12006
- Author(s)
  Ahmed, S., Jin, X., Yagi, M., Yasuda, C., Sato, Y., Higashi, S., Lin, C-Y., Dickson, R.B., Miyazaki, K.
- Journal Title
  
  IGFBP-rP1/angiomodulin/mac25.FEBS J. 273
  
  Pages: 615-627
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014077
[Journal Article] Production of soluble matriptase by human cancer cell lines and cell surface activation of its zymogen by trypsin.2005
- Author(s)
  Jin, X., Hirosaki, T., Lin, C-Y, Dickson, R. B., Higashi, S., Kitamura, H., Miyazaki, K.
- Journal Title
  
  J.Cell.Biochem. 95
  
  Pages: 632-647
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014077
[Journal Article] Pericellular proteolysis by matrix metallo proteinase-7 is differentially modulated by cholesterol sulfate, sulfatide and cardiolipin
- Author(s)
  Yamamoto, K., Miyazaki, K., Higashi, S
- Journal Title
  
  FEBS J
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23300351
[Patent] 改変型APP-IP,改変型APP-IPとTIMP-1との融合タンパク質,及びMMP-9の阻害剤2017
- Inventor(s)
  東　昌市
- Industrial Property Rights Holder
  東　昌市
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2017-254802
- Filing Date
  2017
- Data Source
  KAKENHI-PROJECT-16K12900
[Patent] β-アミロイド前躯体蛋白質由来マトリックスメタロプロテアーゼ2インヒビターペプチドと組織メタロプロテアーゼ阻害物質との融合タンパク質2009
- Inventor(s)
  東昌市
- Industrial Property Rights Holder
  公立大学法人横浜市立大学
- Filing Date
  2009-10-05
- Overseas
- Data Source
  KAKENHI-PROJECT-21570118
[Patent] β-アミロイド前駆体蛋白質由来マトリックスメタロプロテアーゼ2インヒビターペプチドと組織メタロプロテアーゼ阻害物質との融合タンパク質2009
- Inventor(s)
  東昌市
- Industrial Property Rights Holder
  公立大学法人横浜市立大学
- Filing Date
  2009-10-05
- Overseas
- Data Source
  KAKENHI-PROJECT-21570118
[Presentation] がん悪性進展に関与するMMPsを分子標的とした高特異性阻害剤の開発。2023
- Author(s)
  東昌市
- Organizer
  第28回日本病態プロテアーゼ学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-19K07047
[Presentation] 弱酸性条件下でのマトリプターゼ活性発現とそのMMP-7誘導性がん細胞凝集機構における意義。2023
- Author(s)
  五十畑萌、東昌市
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19K07047
[Presentation] MMP-7が誘導するがん細胞凝集機構における膜型セリンプロテアーゼ活性発現機序の解析。2023
- Author(s)
  五十畑萌、東昌市
- Organizer
  第28回日本病態プロテアーゼ学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07047
[Presentation] マトリプターゼ前駆体の細胞外輸送にはその触媒ドメイン内における活性型コンフォメーションの誘導が重要である。2023
- Author(s)
  池田小春、東昌市
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19K07047
[Presentation] マトリプターゼ前駆体の細胞外輸送には触媒ドメインにおける活性型コンフォメーションの誘導が重要である。2023
- Author(s)
  池田小春、東昌市
- Organizer
  第28回日本病態プロテアーゼ学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07047
[Presentation] MMP-7が誘導するがん細胞凝集機構におけるエンドサイトーシスの寄与2022
- Author(s)
  冨永明里、東昌市
- Organizer
  第9５回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19K07047
[Presentation] MMP-7が誘導するがん細胞凝集機構におけるエンドサイトーシスおよび細胞内シグナルの寄与2022
- Author(s)
  冨永明里、東昌市
- Organizer
  第２７回日本病態プロテアーゼ学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07047
[Presentation] MMP-7が誘導するがん細胞凝集に及ぼす化合物スラミンの阻害効果2022
- Author(s)
  杢野弘樹、常住淳、東昌市
- Organizer
  第２７回日本病態プロテアーゼ学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07047
[Presentation] 化合物スラミンはMMP-7が誘導するがん細胞の細胞凝集を阻害する。2021
- Author(s)
  杢野弘樹、常住淳、東昌市
- Organizer
  第9４回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19K07047
[Presentation] MMP-7が誘導するがん細胞凝集機構におけるマトリプターゼ活性の寄与。2021
- Author(s)
  冨永明里、常住淳、東昌市
- Organizer
  第9４回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19K07047
[Presentation] 細胞接着因子としての可溶性HAI-1の機能解析.2017
- Author(s)
  石川智弘, 木村弥生, 平野久, 東昌市
- Organizer
  第90回日本生化学会大会（2017年度生命科学系学会合同年次大会, ConBio2017）
- Data Source
  KAKENHI-PROJECT-16K12900
[Presentation] MMP-7により切断・放出された可溶性HAI-1のがん細胞表層との相互作用の解析.2017
- Author(s)
  石川智弘, 木村弥生, 平野久, 東昌市
- Organizer
  第２２回日本病態プロテアーゼ学会学術集会
- Data Source
  KAKENHI-PROJECT-16K12900
[Presentation] HAI-1の切断修飾を介したMMP-7によるがん転移能増強機構の解析.2017
- Author(s)
  石川智弘, 木村弥生, 平野久, 東昌市
- Organizer
  第２６回日本がん転移学会
- Data Source
  KAKENHI-PROJECT-16K12900
[Presentation] MMP-2選択的インヒビターペプチドAPP-IPのアミノ酸改変による新規MMP-2インヒビターの開発。2016
- Author(s)
  近藤優希、東昌市
- Organizer
  第２１回日本病態プロテアーゼ学会学術集会
- Place of Presentation
  大阪府豊中市
- Year and Date
  2016-08-05
- Data Source
  KAKENHI-PROJECT-16K12900
[Presentation] 培養がん細胞においてMMP-7がセリンプロテアーゼ様活性を促進する機構の解析。2016
- Author(s)
  石川智弘、木村弥生、平野久、東昌市
- Organizer
  第８９回日本生化学会大会
- Place of Presentation
  宮城県仙台市
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-16K12900
[Presentation] MMP-9に対し高い選択性を持つペプチドインヒビターの分子設計。2016
- Author(s)
  佐々木祐太、東昌市
- Organizer
  第８９回日本生化学会大会
- Place of Presentation
  宮城県仙台市
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-16K12900
[Presentation] 可溶性HAI-1による細胞間接着機構の解析。2016
- Author(s)
  石川智弘、木村弥生、平野久、東昌市
- Organizer
  第２１回日本病態プロテアーゼ学会学術集会
- Place of Presentation
  大阪府豊中市
- Year and Date
  2016-08-05
- Data Source
  KAKENHI-PROJECT-16K12900
[Presentation] MMP-2選択的インヒビターペプチドAPP-IPのアミノ酸改変による新規MMP-2インヒビターの開発。2016
- Author(s)
  近藤優希、東昌市
- Organizer
  第８９回日本生化学会大会
- Place of Presentation
  宮城県仙台市
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-16K12900
[Presentation] MMP-9に対して高い阻害活性と選択性を併せ持つペプチドインヒビターの開発。2016
- Author(s)
  佐々木祐太、東昌市
- Organizer
  第２１回日本病態プロテアーゼ学会学術集会
- Place of Presentation
  大阪府豊中市
- Year and Date
  2016-08-05
- Data Source
  KAKENHI-PROJECT-16K12900
[Presentation] N-terminal fragments of laminin γ2 chain stimulate migration of metastatic breast cancer cells by interacting with CD442015
- Author(s)
  Miyazaki, K., Sato, H., Higashi, S.
- Organizer
  第74回日本癌学会総会
- Place of Presentation
  名古屋
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-26430119
[Presentation] 癌の浸潤、転移を支えるMMP-7に対し、高い選択性を持つインヒビターペプチドの開発2015
- Author(s)
  近藤優希、東昌市
- Organizer
  第20回日本病態プロテアーゼ学会学術集会
- Place of Presentation
  名古屋市
- Year and Date
  2015-08-21
- Data Source
  KAKENHI-PROJECT-25440033
[Presentation] MMP-7による切断を受けた後、細胞間接着の誘導に関与するHAI-1分子内領域の同定2015
- Author(s)
  石川智弘、木村弥生、平野久、東昌市
- Organizer
  BMB2015（第３８回日本分子生物学会年会・第８８回日本生化学会大会・合同大会）
- Place of Presentation
  神戸市
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25440033
[Presentation] MT1-MMPに対して高い阻害活性・選択性を併せ持つペプチドインヒビターの開発2015
- Author(s)
  佐々木祐太、東昌市
- Organizer
  第20回日本病態プロテアーゼ学会学術集会
- Place of Presentation
  名古屋市
- Year and Date
  2015-08-21
- Data Source
  KAKENHI-PROJECT-25440033
[Presentation] 可溶性HAI-1の細胞間接着活性部位の同定2015
- Author(s)
  石川智弘、木村弥生、平野久、東昌市
- Organizer
  第20回日本病態プロテアーゼ学会学術集会
- Place of Presentation
  名古屋市
- Year and Date
  2015-08-21
- Data Source
  KAKENHI-PROJECT-25440033
[Presentation] 癌転移を支えるMMP-7に対し、高い阻害選択性を持つインヒビターペプチドの開発2015
- Author(s)
  近藤優希、東昌市
- Organizer
  BMB2015（第３８回日本分子生物学会年会・第８８回日本生化学会大会・合同大会）
- Place of Presentation
  神戸市
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25440033
[Presentation] MMP-14に対し高い選択性を持つペプチドインヒビターの分子設計2015
- Author(s)
  佐々木祐太、東昌市
- Organizer
  BMB2015（第３８回日本分子生物学会年会・第８８回日本生化学会大会・合同大会）
- Place of Presentation
  神戸市
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25440033
[Presentation] Angiomodulin, a cancer blood vessel marker induced by VEGF, enhances vascular permeability through integrin alpha-v/beta-3.2013
- Author(s)
  Eriko Komiya, Hiroki Sato, Shouich Higashi, Yohei Miyagi, Kaoru Miyazaki
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23300351
[Presentation] 極めて特異性の高いMMP-2インヒビタータンパク質の分子設計とそのin vitroがん細胞浸潤に及ぼす効果の解析。2013
- Author(s)
  佐野未奈、東昌市
- Organizer
  第18回日本病態プロテアーゼ学会学術集会
- Place of Presentation
  大阪府豊中市
- Data Source
  KAKENHI-PROJECT-25440033
[Presentation] Angiomodulin, a cancer blood vessel marker induced by VEGF, enhances vascular permeability through integrin alpha-v/beta-32013
- Author(s)
  Eriko Komiya, Hiroki Sato, Shouich Higashi, Yohei Miyagi, Kaoru Miyazaki
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23300351
[Presentation] A synthetic inhibitor of TGF- stimulates tumor cell invasion by enhancing secretion of HGF from fibroblasts in vitro.2013
- Author(s)
  Jun Oyanagi1, Shouichi Higashi, Keiji Kikuchi, Katsuya Sakai, Kunio Matsumoto, and Kaoru Miyazaki
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23300351
[Presentation] Laminin gannma2 Chain Induces Vascular Hyperpermeability through Its Heparin-Binding Site of N-terminal EGF-like Repeat.2013
- Author(s)
  Hiroki Sato, Shouichi Higashi and Kaoru Miyazaki
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23300351
[Presentation] Laminin gannma2 Chain Induces Vascular Hyperpermeability through Its Heparin-Binding Site of N-terminal EGF-like Repeat2013
- Author(s)
  Hiroki Sato, Shouichi Higashi and Kaoru Miyazaki
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23300351
[Presentation] 細胞外マトリックスタンパク質ラミニン-332による単球からのマトリックスプロテイナーゼ-9産生調節。2013
- Author(s)
  鴨志田剛、小川崇、小柳潤、佐藤拓輝、古宮栄利子、東昌市、宮崎香、斧康雄、辻勉
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  神奈川県横浜市
- Data Source
  KAKENHI-PROJECT-25440033
[Presentation] Angiomodulin (AGM/IGFBP-rP1) is overexpressed in tumor vasculature and regulates adhesion of vascular endothelial cells via integrin αvβ3 : Possible roles in tumor angiogenesis2013
- Author(s)
  Kaoru Miyazaki, Eriko Komiya, Hiroki Sato, Yohei Miyagi, Shouichi Higashi
- Organizer
  AACR Conference "Tumor Invasion and Metastasis"
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-23300351
[Presentation] ラミニンγ2鎖による血管透過性亢進は、N末端部EGF様リピートのヘパリン結合部に依存する。2013
- Author(s)
  佐藤拓輝、東昌市、宮崎香
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  神奈川県横浜市
- Data Source
  KAKENHI-PROJECT-25440033
[Presentation] 3次元浸潤モデル系を用いたMMP-2特異的インヒビターのがん細胞浸潤抑制効果の解析。2013
- Author(s)
  佐野未奈、小柳潤、宮崎香、東昌市
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  神奈川県横浜市
- Data Source
  KAKENHI-PROJECT-25440033
[Presentation] A synthetic inhibitor of TGF- stimulates tumor cell invasion by enhancing secretion of HGF from fibroblasts in vitro2013
- Author(s)
  Jun Oyanagi, Shouichi Higashi, Keiji Kikuchi, Katsuya Sakai, Kunio Matusmoto, Kaoru Miyazaki
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23300351
[Presentation] EMT of tumor cells promotes microtubule-based protrusions in 3D collagen matrix, suppressing cell growth2012
- Author(s)
  Jun Oyanagi, Hiroki Sato, Shouichi Higashi, Kaoru Miyazaki
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23300351
[Presentation] Overxpression of Angiomodulin (AGM/IGFBPrP1) in Tumor Stroma and Vasculature : Differential Regulation and Functions2012
- Author(s)
  Eriko Komiya, Hiroki Sato, Shouich Higashi, Yohei Miyagi, Kaoru Miyazaki
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23300351
[Presentation] Laminin γ2 Chain Induces Transendothelial Migration of Cancer Cells by Modulating Cytoskeleton of Endothelial Cells2012
- Author(s)
  Hiroki Sato, Jun Oyanagi, Eriko Komiya, Shouichi Higashi, Kaoru Miyazaki
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23300351
[Presentation] Overxpression of Angiomodulin (AGM/IGFBPrP1) in Tumor Stroma and Vasculature : Differential Regulation and Functions2012
- Author(s)
  Eriko komiya, Hiroki Sato, Yohei Miyagi, Shouichi Higashi, Kaoru Miyazaki
- Organizer
  The 14th International Biennial Congress of the Metastasis Research Association
- Place of Presentation
  Brisbane, Australia
- Data Source
  KAKENHI-PROJECT-23300351
[Presentation] Laminin γ2 chain Promotes Invasion of Tumor Cells into Vascular Endothelial Cell Layer In Vitro2012
- Author(s)
  Hiroki Sato, Takashi Ogawa, Eriko Komiya, Jun Oyanagi, Shouichi Higashi, Kaoru Miyazaki
- Organizer
  The 14th International Biennial Congress of the Metastasis Research Association
- Place of Presentation
  Brisbane, Australia
- Data Source
  KAKENHI-PROJECT-23300351
[Presentation] MMP-2とAPP由来インヒビターペプチドとの複合体の結晶構造解析2011
- Author(s)
  竹内友香、橋本博、宮崎香、佐藤衛、東昌市
- Organizer
  第16回日本病態プロテアーゼ学会学術集会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-21570118
[Presentation] APP 由来インヒビターペプチドによる MMP-2 選択的阻害機構の解明2011
- Author(s)
  竹内友香, 橋本博, 宮崎香, 佐藤衛, 東昌市
- Organizer
  第84回生化学会大会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23300351
[Presentation] 腫瘍由来接着因子IGFBP-rP1/TAFはヒト繊維芽細胞の増殖とフィブロネクチン産生を促進する2011
- Author(s)
  古宮栄利子、東昌市、宮崎香
- Organizer
  第70回日本癌学会学術集会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-21570118
[Presentation] APP由来インヒビターペプチドによるMMP-2選択的阻害機構の解明2011
- Author(s)
  竹内友香、橋本博、宮崎香、佐藤衛、東昌市
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21570118
[Presentation] Laminin γ2 chain Promotes Invasion of Tumor Cells into Vascular Endothelial Cell Layer In Vitro2011
- Author(s)
  Hiroki Sato, Jun Oyanagi, Shouichi Higashi, Kaoru Miyazaki
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23300351
[Presentation] Epithelial-mesenchymal transition promotes invadopodia-like protrusions in collagen gel., suppressing cell growth2011
- Author(s)
  Jun oyanagi, Hiroki Sato, Shouichi Higashi, Kaoru Miyazaki
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23300351
[Presentation] Epithelial-mesenchymal transition (EMT) stimulates tumor cells to produce invadopodia-like protrusions in collagen matrix, suppressing cell growth2011
- Author(s)
  Jun Oyanagi, Shouichi Higashi, Kaoru Miyazaki
- Organizer
  American Association for Cancer Research 102nd Annual Meeting Innovation and Collaboration to Progress
- Place of Presentation
  Florida in U.S.A
- Data Source
  KAKENHI-PROJECT-23300351
[Presentation] Tumor-derived adhesion factor IGFBP-rP1/TAF promotes growth of human fibroblasta and their fibronectin expression2011
- Author(s)
  Eriko Komiya, Kaoru Miyazaki, Shouichi Higashi
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23300351
[Presentation] Epithelial-mesenchymal transition(EMT) stimulates tumor cells to produce invadopodia-like protrusions in collagen matrix, suppressing cell growth2011
- Author(s)
  Jun Oyanagi, Shouichi Higashi, Kaoru Miyazaki
- Organizer
  American Association for Cancer Research 102nd Annual Meeting
- Place of Presentation
  Orlando, FL
- Data Source
  KAKENHI-PROJECT-21570118
[Presentation] 上皮-間葉変換はコラーゲンゲル中でInvadopodia様の突起形成を促進する-方で細胞増殖を抑制する2011
- Author(s)
  小柳潤、佐藤拓輝、東昌市、宮崎香
- Organizer
  第70回日本癌学会学術集会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-21570118
[Presentation] がん浸潤マーカー・ラミニンγ2鎖は、がん細胞の血管内皮単層下への浸潤を促進する2011
- Author(s)
  佐藤拓輝、小柳潤、東昌市、宮崎香
- Organizer
  第70回日本癌学会学術集会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-21570118
[Presentation] がん浸潤マーカー「ラミニンγ2鎖」と血管内皮細胞の相互作用2010
- Author(s)
  佐藤拓輝、小柳潤、藤田幸、東昌市、宮崎香
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-21570118
[Presentation] IGF結合タンパク質様分子(IGFBP-rP1)の腫瘍増殖抑制における間質との相互作用2010
- Author(s)
  古谷桃子、古宮栄利子、東昌市、宮崎香
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-21570118
[Presentation] MMP-2に対し、高い特異性と阻害活性をもつインヒビタータンパク質の分子設計2010
- Author(s)
  東昌市、宮崎香
- Organizer
  第69回日本癌学会学術集会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-21570118
[Presentation] コレステロール硫酸との相互作用に伴うMMP-7の基質特異性変化と細胞近傍タンパク質の選択的分解促進機構2010
- Author(s)
  東昌市
- Organizer
  第33回分子生物学会/第83回日本生化学会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-21570118
[Presentation] コレステロール硫酸との相互作用に伴うMMP-7の基質特異性変化と細胞近傍タンパク質の選択的分解促進機構2010
- Author(s)
  東昌市、山本和博、宮崎香
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-21570118
[Presentation] 血管基底膜に存在する新規ラミニン分子3B11の性質と腫瘍血管における発現抑制2010
- Author(s)
  森泰三、東昌市、関口清俊、宮城洋平、宮崎香
- Organizer
  第69回日本癌学会学術集会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-21570118
[Presentation] 細胞表層のコレステロール硫酸を介したMMP-7前駆体(proMMP-7)活性化機構の解析2010
- Author(s)
  小松恭子、東昌市、宮崎香
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-21570118
[Presentation] IGF結合タンパク質様分子IGFBP-rP1の乳がん組織血管での発現誘導2010
- Author(s)
  伊勢まりい、古宮栄利子、古谷桃子、東昌市、宮崎香
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-21570118
[Presentation] Cholesterol sulfate alters substrate preference of MMP-7 and promotes degradation of selective pericellular proteins.2010
- Author(s)
  Shouichi Higashi, Kaoru Miyazaki, et al.
- Organizer
  第33回分子生物学会/第83回日本生化学会合同大会
- Place of Presentation
  神戸ポートアイランド(兵庫>
- Data Source
  KAKENHI-PROJECT-17014077
[Presentation] Molecular design of a highly selective and strong inhibitor against MMP-2.2010
- Author(s)
  Shouichi Higashi, Kaoru Miyazaki, et al.
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪国際会議場他(大阪)
- Data Source
  KAKENHI-PROJECT-17014077
[Presentation] IGFBP-rP1/TAFとラミニン332のがん細胞に対する協調的な促進作用2009
- Author(s)
  古宮栄利子、東昌市、宮崎香
- Organizer
  第68回日本癌学会学術集会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-21570118
[Presentation] マトリプターゼ(MT-SP1)によるCTGF(IGFBP-rP2)の切断と腫瘍増殖促進作用2009
- Author(s)
  寺田翔、迫田明子、東昌市、宮崎香
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-21570118
[Presentation] Insulin-like growth factor binding protein-related protein 1(1rP1/TAF) synergistically modulates tumor cell adhesion with laminin-332(laminin-5)2009
- Author(s)
  Eriko Komiya, Marii Ise, Yuichiro Sato, Shouich Higashi and Kaoru Miyazaki
- Organizer
  Yokosuka Science Festa 2009 8^<th> Pan-pacific connective Tissue Societies Symposium
- Place of Presentation
  Yokosuka Japan
- Data Source
  KAKENHI-PROJECT-21570118
[Presentation] マトリックスメタプロテアーゼ-2(MMP-2)に対し、高い特異性を持つインヒビタータンパク質の設計2009
- Author(s)
  廣瀬智一、東昌市、宮崎香
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-21570118
[Presentation] APP由来インヒビターによる選択的活性阻害に重要なMMP-2分子内のアミノ酸残基の同定2008
- Author(s)
  東昌市、宮崎香
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-17014077
[Presentation] Matriptaseによる腫瘍増殖機構の解析一IGFBPsの切断の意義について2008
- Author(s)
  迫田明子、山本和博、寺田翔、秋山渚、東昌市、宮崎香
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-17014077
[Presentation] 癌の悪性形質を支えるMMP-2およびMMP-7の細胞表層での活性発現機序とそれを応用した高特異性阻害剤の開発2008
- Author(s)
  東昌市、山本和博、宮崎香
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-17014077
[Presentation] がん細胞浸潤および血管内皮細胞増殖に及ぼす高特異性MMP-2 インヒビターの効果。
- Author(s)
  佐野未奈、東昌市
- Organizer
  第36回日本血栓止血学会
- Place of Presentation
  大阪国際交流センター（大阪市天王寺区）
- Year and Date
  2014-05-29 – 2014-05-31
- Data Source
  KAKENHI-PROJECT-25440033
[Presentation] 高特異性MMP-2インヒビターのがん細胞浸潤抑制効果と血管新生に及ぼす効果。
- Author(s)
  佐野未奈、東昌市
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  国立京都国際会館（京都市左京区）
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-25440033
[Presentation] MMP-7により切断修飾を受ける細胞表層タンパク質の同定。
- Author(s)
  石川智弘、木村弥生、平野久、東昌市
- Organizer
  第19回日本病態プロテアーゼ学会学術集会
- Place of Presentation
  千里ライフサイエンスセンター（大阪府豊中市）
- Year and Date
  2014-08-08 – 2014-08-09
- Data Source
  KAKENHI-PROJECT-25440033
[Presentation] がん細胞表層に結合したMMP-7によって切断され、細胞凝集を惹起するタンパク質の同定。
- Author(s)
  石川智弘、木村弥生、平野久、東昌市
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  国立京都国際会館（京都市左京区）
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-25440033
[Presentation] ヒト 26S プロテアソームサブユニットのリン酸化修飾状態の解析。
- Author(s)
  得津奏子、菅原経継、井野洋子、倉田洋一、木村弥生、東昌市、平野久
- Organizer
  第65回日本電気泳動学会総会・シンポジウム
- Place of Presentation
  横浜情報文化センター（横浜市中区）
- Year and Date
  2014-10-24 – 2014-10-25
- Data Source
  KAKENHI-PROJECT-25440033
[Presentation] がん浸潤マーカー・ラミニンγ2 鎖の血管内皮下浸潤活性とその機構。
- Author(s)
  佐藤拓輝，東昌市
- Organizer
  第36回日本血栓止血学会
- Place of Presentation
  大阪国際交流センター（大阪市天王寺区）
- Year and Date
  2014-05-29 – 2014-05-31
- Data Source
  KAKENHI-PROJECT-25440033
[Presentation] Three-dimensional collagen gel co-culture model as a tool to investigate tumor invasion: roles of HGF and TGF-beta
- Author(s)
  Miyazaki, K., Jun Oyanagi, J., Shouichi Higashi, S., Kikuchi, K., Sakai, K., Matsumoto, K.
- Organizer
  日本癌学会総会
- Place of Presentation
  横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-26430119
[]

1. MIYAZAKI Kaoru (70112068)

# of Collaborated Projects: 7 results

# of Collaborated Products: 51 results
2. YASUMITSU Hidetaro (10182346)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. OGAWA Takashi (80405018)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. SATO MAMORU (60170784)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
5. HASHIMOTO HIROSHI (40336590)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. IWANAGA Sadaaki (90029942)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. NAKAGAWA Kazunori (50217668)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. MUTA Tatsushi (60222337)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. KAWABATA Shun-ichiro (90183037)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. SUEISHI Katsuo (70108710)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. ICHINOSE Akitada (10241689)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. NAGASHIMA Yoji (10217995)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. KIMURA YAYOI (80391936)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
14. MIYAGI Yohei (00254194)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 西村仁 (80241347)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 武谷浩之 (60222105)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. FUJIKAWA Kazuo

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. EARL W.Davie

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. DAVIE Earl W

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. SHIMADA Yukihisa

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 山崎千秋

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 中村郁子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Higashi Shoichi 東 昌市

Higashi Shouichi 東 昌市

HIGASHI Shouichi 東 昌市

Research Projects

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Co-Researchers

Studies on mechanism of inter cellular adhesion induced by cleavage of cancer cell surface HAI-1 protein and following enhancement of cancer metastasis.Principal Investigator

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Molecular mechanism of MMP-7-enhanced liver metastasis of colon cancer, and its application for liver regenerative medicinePrincipal Investigator

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Design of highly selective MMP inhibitors by coupling selective peptide inhibitors with physiological MMP-binding proteinsPrincipal Investigator

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Development of highly selective inhibitors against individual MMPsPrincipal Investigator

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癌細胞表層に存在するMMP-7機能変換分子の同定とその癌転移促進機構の解析Principal Investigator

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アミロイド前駆体タンパク質によるMMP活性調節機構の解析Principal Investigator

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アミロイド前駆体タンパク質の細胞外放出機構の解析およびその生理的意義の解明Principal Investigator

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Higashi Shoichi 東昌市

Higashi Shouichi 東昌市

HIGASHI Shouichi 東昌市