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HINOKIO Yoshinori  檜尾 好徳

ORCIDConnect your ORCID iD *help
… Alternative Names

桧尾 好徳  ヒノキオ ヨシノリ

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Researcher Number 10282071
Affiliation (based on the past Project Information) *help 2010: 東北大学, 医学系研究科, 非常勤講師
2010: 東北大学, 大学院・医学系・研究科, 准教授
2010: 東北大学, 大学院・医学系研究科, 非常勤講師
2007 – 2009: Tohoku University, 大学院・医学系研究科, 准教授
2008: 東北大学, 医学系研究科, 准教授 … More
2006: Tohoku University, Graduate School of Medicine, Associate Professor, 大学院医学系研究科, 助教授
2005 – 2006: Tohoku University, Hospital, Lecturer, 病院, 講師
2003 – 2006: 東北大学, 病院・講師
2004 – 2005: 東北大学, 大学病院, 講師
2003: Tohoku University, Hospital, Lecturer, 医学部附属病院, 講師
2002: 東北大学, 医学部付属病院, 助手
2002: Tohoku University Hospital, Department of Diabetes and Metabolism, Research Associate, 医学部附属病院, 助手
1998 – 2002: Tohoku University, 3rd Dep Int Med, research associate, 医学部・附属病院, 助手
1998: 東北大学, 医学部附属病院, 助手 Less
Review Section/Research Field
Principal Investigator
Metabolomics / Metabolomics
Except Principal Investigator
Metabolomics / Metabolomics / Biological Sciences / 内分泌・代謝学 / Social dentistry / General surgery
Keywords
Principal Investigator
HNF / type 2 diabetes / 2型糖尿病 / MODY / 分子生物学 / インスリン非依存性糖尿病 / 糖尿病 / oxidative stress / transcription factor / フォークヘッドファミリー … More / 若年発症糖尿病 / 酸化ストレス / 転写因子 / gene mutations / ガングリオシド抗体 / インスリン / 膵ラ島β細胞 / DNA / Chimeric RNA / 一塩基置換修復法 / ミトコンドリアDNA / ミトコンドリア … More
Except Principal Investigator
糖尿病 / Diabetes / インスリン / インスリン抵抗性 / Insulin / CD204 / insulin resistance / インスリン受容体基質1 / インスリン受容体 / シアリダーゼ / ガングリオシド / PDK1 / PKC / acyl-coenzyme A dehydrogenase / GLUT4 / GC-MS / Wolfram syndrome / endoplasmic reticulum / インスリン分泌 / 小胞体ストレス / ノックアウトマウス / WFS1 / ウオルフラム症候群 / 膵β細胞 / Oxidative stress / DNA損傷 / アポトーシス / 糖尿病性網膜症 / 糖尿病性腎症 / 酸化ストレス / ミトコンドリアDNA / Gene knockdown / Liver / Nitric Oxide / Parasympatic nerve / Urotensin II / 遺伝子ノックダウン / 肝臓 / 一酸化窒素 / 副交感神経 / ウロテンシンII / Macrophage scavenger receptor / dendritic cells / type 1 diabetes mellitus / 抗原提示細胞 / スカベンジャー受容体 / NODマウス / 樹状細胞 / 1型糖尿病 / insulin receptor substrate 1 / insulin receptor / glucose tolerance / adenovirus vector / sialidase / ganglioside / diabetes / 耐糖能 / アデノウイルスベクター / inositol glycan / impairment of insulin secretion / GPI specific phospholipase D / Type 2 diabetes mellitus / イノシトールグリカン / インスリン分泌不全 / GPI特異的フォスフォリパーゼD / 2型糖尿病 / Insulin receptor substrate 1 / Insulin receptor / Knockout mice / Transgenic mice / Insulin resistance / Sialidase / Ganglioside / タンスジェニックマウス / トラスジェニックマウス / intracellular signaling / glucose transport / インスリン反応性アミノペプチダーゼ / acy1-CoA dehdrogenase / GFP / シグナル伝達 / 糖輸送 / cell cycle / Endoplasmic reticulum stress / pancreatic B cell / Insulin secretion / glutamate / PPARa / GLUD1 / GDH / GPLD1 / ウェルナー症候群 / SNP / 細胞周期 / 8-oxo-deoxyguanosine / Oxidative DNA damage / Diabetic retinopathy / Diabetic nephropathy / Diabetic complication / Diabetes mellitus / 活性酸素 / 8-OXO-deoxyguanosine / 8-oxo-deoxyguanosive / 酸化的DNA損傷 / 糖尿病合併症 / knock-out mice / pancreatic β cell / 視神経萎縮 / ER(endoplasmic reticulum) / 小胞体 / diabetic retinopathy / diabetic nephropathy / mitochondrial DNA / 8-oxo-2'-deoxyguanosine / 8-hydroxydeoxyguanosine / 口腔内環境 / 口臭 / 呼気 / 口腔環境 / ケトン体 / 揮発性硫黄化合物 / アセトン / 血糖 / 二次元評価 / 口内気体 / 予防歯科学 / 膵島 / 細胞・組織 / 移植・再生医療 / ガングリオシド抗体 / 膵ラ島β細胞 / DNA / Chimeric RNA / 一塩基置換修復法 / ミトコンドリア Less
  • Research Projects

    (17 results)
  • Research Products

    (23 results)
  • Co-Researchers

    (23 People)
  •  Establishment of minimally invasive cell therapy for diabetes by improving the outcome of pancreatic islet transplantation

    • Principal Investigator
      GOTO Masafumi
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General surgery
    • Research Institution
      Tohoku University
  •  Two dimensional evaluation by volatile gases for oral condition of diabetes mellitus

    • Principal Investigator
      TANDA Naoko
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Social dentistry
    • Research Institution
      Tohoku University
  •  ミトコンドリア遺伝子異常糖尿病に対する遺伝子治療の開発Principal Investigator

    • Principal Investigator
      檜尾 好徳 (桧尾 好徳)
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Metabolomics
    • Research Institution
      Tohoku University
  •  A unique CD204^+ subpopulation of dendritic cells in NOD mice

    • Principal Investigator
      TAKAHASHI Kazuma
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Metabolomics
    • Research Institution
      Tohoku University
  •  Signaling axis of urotensin II, parasympathetic nerves, and nitric oxide on carbohydrate metabolism: A clinical

    • Principal Investigator
      TAMURA Akira
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Metabolomics
    • Research Institution
      Tohoku University
  •  膵ラ島β細胞ミトコンドリアを標的とする遺伝子治療の開発

    • Principal Investigator
      SUZUKI Susumu
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Metabolomics
    • Research Institution
      Tohoku University
  •  Elucidation of abnormality of plasma membrane microdomain in type 2 diabetes mellitus

    • Principal Investigator
      SUZUKI Susumu
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Metabolomics
    • Research Institution
      Tohoku University
  •  The role of genes of forkhead transcription factors in type2 diabetes and obesity.Principal Investigator

    • Principal Investigator
      HINOKIO Yoshinori
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Metabolomics
    • Research Institution
      Tohoku University
  •  The role of plasma membrane type sialidase gene Neu3 on the pathogenesis of type 2 diabetes mellitusin Japanese.

    • Principal Investigator
      SUZUKI Susumu
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Metabolomics
    • Research Institution
      Tohoku University
  •  The role of phospholipase D in the development of diabetes mellitus

    • Principal Investigator
      HIRAI Masashi
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Metabolomics
    • Research Institution
      TOHOKU UNIVERSITY
  •  Elucidation of diabetes-related genes

    • Principal Investigator
      OKA Yoshitomo
    • Project Period (FY)
      2001 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Tohoku University
  •  Studies on mechanisms of insulin-stimulated glucose transport : analysis of downstream signaling and real-time monitoring of GLUT4 translocation

    • Principal Investigator
      OKA Yoshitomo
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Metabolomics
    • Research Institution
      Tohoku University
  •  The cascade of hepatocyte nuclear factor in early-onset diabetes.Principal Investigator

    • Principal Investigator
      HINOKIO Yoshinori
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Metabolomics
    • Research Institution
      Tohoku University
  •  Generation of Wolfram syndrome mice, aiming at development of new therapeutics for diabetes through preserving pancreatic beta cells

    • Principal Investigator
      OKA Yoshitomo
    • Project Period (FY)
      2000 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Metabolomics
    • Research Institution
      Tohoku University
      Yamaguchi University
  •  Development of a new assay method for oxidative DNA damages in diabetes

    • Principal Investigator
      SUZUKI Susumu
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Metabolomics
    • Research Institution
      Tohoku University
  •  The HNF-related transcription cascade in maturity-onset diabetes of the young.Principal Investigator

    • Principal Investigator
      HINOKIO Yoshinori
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Metabolomics
    • Research Institution
      Tohoku University
  •  Role of oxidative DNA damage in the pathogenesis of diabetic complications

    • Principal Investigator
      SUZUKI Susumu
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      内分泌・代謝学
    • Research Institution
      Tohoku University

All 2011 2010 2009 2008 2007 2005 2004

All Journal Article Presentation

  • [Journal Article] A novel method for evaluating human carotid artery elasticity: possible detection of early stage atherosclerosis in subjects with type 2 diabetes.2008

    • Author(s)
      Okimoto H, Ishigaki Y, Koiwa Y, Hinokio Y, Ogihara T, Suzuki S, Katagiri H, Ohkubo T, Hasegawa H,
    • Journal Title

      Atherosclerosis. 196

      Pages: 391-397

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18659263
  • [Journal Article] Possible relevance of HLA-DRB1*0403 haplotype in insulin autoimmune syndrome induced by α-lipoic acid, used as a dietary supplement.2007

    • Author(s)
      Yamada T, Imai J, Ishigaki Y, Hinokio Y, Oka Y, Katagiri H.
    • Journal Title

      Diabetes Care 30

      Pages: 131-131

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18659263
  • [Journal Article] Increased hepatic expression of ganglioside-specific sialidase, NEU3, improves insulin sensitivity and glucose tolerance in mice.2007

    • Author(s)
      Yoshizumi S, Suzuki S, Hirai M, Hinokio Y, Yamada T, Yamada T,
    • Journal Title

      Metabolism 56

      Pages: 420-429

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18659263
  • [Journal Article] Genetic variations of urotensin II gene in type 2 diabetes2005

    • Author(s)
      Hinokio Y, Suzuki S, Oka Y.
    • Journal Title

      Nippon Rinsho 63

      Pages: 193-197

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590862
  • [Journal Article] WRN gene 1367 Arg allele protects against development of type 2 diabetes mellitus2005

    • Author(s)
      Hirai M, Suzuki S, Hinokio Y, et al.
    • Journal Title

      Diabetes Res Clin Pract. 69

      Pages: 287-292

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-13204062
  • [Journal Article] WRN gene 1367 Arg allele protects against development of type 2 diabetes mellitus.2005

    • Author(s)
      Hirai M, Suzuki S, Hinokio Y, Yamada T, et al.
    • Journal Title

      Diabetes Res Clin Pract. 69・3

      Pages: 287-292

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390259
  • [Journal Article] WRN gene 1367 Arg allele protects against development of type 2 diabetes mellitus.2005

    • Author(s)
      Hirai M, Suzuki S, Hinokio Y, Yamada T, et al.
    • Journal Title

      Diabetes Res Clin Pract 69・3

      Pages: 287-92

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16390259
  • [Journal Article] WRN gene 1367 Arg allele protects against development of type 2 diabetes mellitus.2005

    • Author(s)
      Hirai M, Suzuki S, Hinokio Y, Yamada T, Yoshizumi S, Suzuki C, Satoh J, Oka Y.
    • Journal Title

      Diabetes Res Clin Pract. 69

      Pages: 287-292

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590862
  • [Journal Article] WRN gene 1367 Arg allele protects against development of type 2 diabetes mellitus.2005

    • Author(s)
      Hirai M, Suzuki S, Hinokio Y, Yamada T, Yoshizumi S, Suzuki C, Satoh J, Oka Y.
    • Journal Title

      Diabetes Res Clin Pract 69

      Pages: 287-292

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590862
  • [Journal Article] WRN gene 1367 Arg allele protects against development of type 2 diabetes mellitus.2005

    • Author(s)
      Hirai M, Suzuki S, Hinokio Y, et al.
    • Journal Title

      Diabetes Res Clin Pract 69・3

      Pages: 287-292

    • Data Source
      KAKENHI-PROJECT-17590912
  • [Journal Article] WRN gene 1367 Arg allele protects against development of type 2 diabetes mellitus.2005

    • Author(s)
      Hirai M, Suzuki S, Hinokio Y, et al.
    • Journal Title

      Diabetes Res Clin Pract 69・3

      Pages: 287-292

    • Data Source
      KAKENHI-PROJECT-16659236
  • [Journal Article] Secondary sulfonylurea failure : comparison of period until insulin treatment between diabetic patients treated with gliclazide and glibenclamide.2005

    • Author(s)
      Satoh J, Takahashi K, Takizawa Y, Ishihara H, Hirai M, Katagiri H, Hinokio Y, Suzuki S, Tsuji I, Oka Y.
    • Journal Title

      Diabetes Res Clin Pract 70

      Pages: 291-297

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590862
  • [Journal Article] Genetic variations of urotensin II gene in type 2 diabetes2005

    • Author(s)
      Hinokio Y, Suzuki S, Oka Y.
    • Journal Title

      Nippon Rinsho. 63

      Pages: 193-197

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590862
  • [Journal Article] Secondary sulfonylurea failure : comparison of period until insulin treatment between diabetic patients treated with gliclazide and glibenclamide.2005

    • Author(s)
      Satoh J, Takahashi K, Takizawa Y, Ishihara H, Hirai M, Katagiri H, Hinokio Y, Suzuki S, Tsuji I, Oka Y.
    • Journal Title

      Diabetes Res Clin Pract. 70

      Pages: 291-297

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590862
  • [Journal Article] Genetic Variations at Urotensin II and Urotensin II Receptor Genes and Risk of Type 2 Diabetes Mellitus in Japanese.2004

    • Author(s)
      Suzuki S, Wenyi Z, Hirai M, Hinokio Y, Suzuki C, et al.
    • Journal Title

      Peptide 25

      Pages: 1801-1808

    • Data Source
      KAKENHI-PROJECT-16390259
  • [Journal Article] Premoter polymorphism of SLC11A1 (formerly NRAMP1) confers susceptibility to autoimmune type 1 diabetes mellitus in Japanese.2004

    • Author(s)
      Takahashi K, Satoh J, Kojima Y, Negoro K, Hirai M, Hinokio Y, Kinouchi Y, Suzuki S, Matsuura N, Shimosegawa T, Oka Y
    • Journal Title

      Tissue Antigens 63

      Pages: 231-236

    • Data Source
      KAKENHI-PROJECT-16590862
  • [Journal Article] Genetic variations at urotensin II and urotensin II receptor genes and risk of type 2 diabetes mellitus in Japanese.2004

    • Author(s)
      Suzuki S, Zong Wenyi, Hirai M, Hinokio Y, Suzuki C, Yamada T, Yoshizumi S, Suzuki M, Tanizawa Y, Matsunami A, Oka Y
    • Journal Title

      Peptides 25

      Pages: 1803-1808

    • Data Source
      KAKENHI-PROJECT-16590862
  • [Journal Article] Genetic variations at urotensin II and urotensin II receptor genes and risk of type 2 diabetes mellitus in Japanese.2004

    • Author(s)
      Suzuki S, Zong Wenyi, Hirai M, Hinokio Y, Suzuki C, Yamada T, Yoshizumi S, Suzuki M, Tanizawa Y, Matsunami A, Oka Y.
    • Journal Title

      Peptides 25

      Pages: 1803-1808

    • Data Source
      KAKENHI-PROJECT-13204062
  • [Journal Article] Genetic Variations at Urotensin II and Urotensin II Receptor Genes and Risk of Type 2 Diabetes Mellitus in Japanese.2004

    • Author(s)
      Suzuki S, Wenyi Z, Hirai M, Hinokio Y, Suzuki C, et al.
    • Journal Title

      Peptide 25

      Pages: 1801-1808

    • Data Source
      KAKENHI-PROJECT-16659236
  • [Presentation] Breath acetone in type 1 and type 2 diabetes mellitus2011

    • Author(s)
      丹田奈緒子、檜尾好徳、鷲尾純平、高橋信博、小関健由
    • Organizer
      第4回インターフェイス口腔健康科学国際シンポジウム
    • Place of Presentation
      仙台
    • Year and Date
      2011-03-08
    • Data Source
      KAKENHI-PROJECT-20592447
  • [Presentation] Acetone in Mouth Air in Type 2 Diabetes Mellitus2010

    • Author(s)
      丹田奈緒子、檜尾好徳、鷲尾純平、高橋信博、小関健由
    • Organizer
      the 88^<th> General Session & Exhibition of the International Association for Dental Research
    • Place of Presentation
      バルセロナ、スペイン
    • Year and Date
      2010-07-16
    • Data Source
      KAKENHI-PROJECT-20592447
  • [Presentation] 入院中に口腔環境改善を試みた治療コンプライアンスの低い2型糖尿病の1例2009

    • Author(s)
      丹田奈緒子、檜尾好徳、由浪有希子、鷲尾純平、高橋信博、小関健由、片桐秀樹、岡芳知
    • Organizer
      日本糖尿病学会第47回東北地方会
    • Place of Presentation
      仙台
    • Year and Date
      2009-11-07
    • Data Source
      KAKENHI-PROJECT-20592447
  • [Presentation] 東北大学における膵島移植の取り組み2008

    • Author(s)
      後藤昌史、檜尾好徳、小川則彦、山谷英之、高橋英幸、齋藤之彦、戸子台和哲、関口悟、石原寿光、藤盛啓成、黒川良望、岡芳知、里見進
    • Organizer
      第44回日本移植学会
    • Place of Presentation
      大阪市, 大阪府
    • Data Source
      KAKENHI-PROJECT-20390337
  • 1.  HIRAI Masashi (80312578)
    # of Collaborated Projects: 11 results
    # of Collaborated Products: 13 results
  • 2.  SUZUKI Susumu (70216399)
    # of Collaborated Projects: 10 results
    # of Collaborated Products: 14 results
  • 3.  ISHIHARA Hisamitsu (60361086)
    # of Collaborated Projects: 9 results
    # of Collaborated Products: 2 results
  • 4.  KATAGIRI Hedeki (00344664)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 2 results
  • 5.  OKA Yoshitomo (70175256)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 1 results
  • 6.  TAKAHASHI Kazuma (60292215)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 7.  MIYAGI Taeko (50006110)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 8.  谷澤 幸生 (00217142)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 9.  湯尻 俊昭
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 10.  GOTO Masafumi (50400453)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 11.  SATOMI Susumu (00154120)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 12.  OKADA Hidechika (30160683)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  MANO Yoshihiro (70014339)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  TANDA Naoko (00422121)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 15.  KOSEKI Takeyoshi (80291128)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 16.  TAKAHASHI Nobuhiro (60183852)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 17.  WASHIO Jumpei (20400260)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 18.  ISHI Naoto (60291267)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  TAMURA Akira (00375023)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  佐々木 輝昌
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  竹田 孔明
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  松本 健
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  谷沢 幸生
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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