Nishiya Naoyuki 西谷直之

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NISHIYA Naoyuki 西谷直之

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Researcher Number	10286867
Other IDs	https://orcid.org/0000-0003-1575-9944
Affiliation (Current)	2025: 岩手医科大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2017 – 2024: 岩手医科大学, 薬学部, 教授 2016: 岩手医科大学, 薬学部, 准教授 2008 – 2016: Iwate Medical University, 薬学部, 講師 2002: 昭和大, 薬学部, 助手 1998 – 2001: 昭和大学, 薬学部, 助手 2000: 昭和大, 薬学部, 助手
Review Section/Research Field	Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / Biological pharmacy / Biological pharmacy Except Principal Investigator Biological Sciences / Biological pharmacy / Basic Section 37020:Chemistry and chemical methodology of biomolecules-related / Drug development chemistry / Dental engineering/Regenerative dentistry / Clinical oncology
Keywords	Principal Investigator 阻害剤 / Wnt / mTOR / シグナル伝達 / ゼブラフィッシュ / 阻害薬 / 薬学 / 発生・分化 / 細胞・組織 / 癌 … More / FAK / Hic-5 / 悪性腫瘍 / Wnt経路 / 化合物 / Notch / リソソーム / β-catenin / 分子標的薬 / がん / 再生医学 / 薬学分子生物学 / 細胞増殖 / integrin / paxillin / 細胞接着斑 … More Except Principal Investigator Hic-5 / c-fos / 核移行 / 接着斑 / パキシリン / focal adhesion / paxillin / 細胞接着斑 / アザラメラリン / ラメラリン / nuclear lozalization / 酸化ストレス / 過酸化水素 / 抗がん剤 / 転写 / レポーター / p16 / 細胞接着 / C797S変異 / キナーゼ / EGFR / EGFRキナーゼ阻害剤 (EGFR-TKI) / F環部改変 / A環部改変 / アファチニブ / 薬剤耐性変異 / アザアメラリン / オシメルチニブ / ゲフィチニブ / L858R/T790M/C797S / L858R/T790M / オシメルチニブ耐性 / ゲフィチニブ耐性 / L858R/T790M/C797S変異 / L858R/T790M変異 / EGFR-TKI / 非小細胞肺がん / マラッセ残存上皮 / エナメル上皮細胞 / エナメル上皮幹細胞 / 歯根膜 / マラッセ上皮遺残 / セマフォリン / 間葉上皮転換 / 歯の再生 / 上皮間葉転換 / ヘルトビッヒ上皮鞘 / 上皮細胞 / p38 / MMP / 核マトリクス / LIM蛋白質 / レドクス / Smad3 / oxidative stress / c-foc / NES / Sp1 / FAK / Hic-5蛋白質 / PTP-PEST / 阻害剤 / 薬学 / がん / DKK1 / 遺伝子発現 / 造腫瘍性 / 幹細胞 / 乳がん / 遺伝子発現プロファイル / 次世代シークエンサー / 次世代シーケンサー / Wntシグナル / TGF-beta / ドキソルビシン / Her2 / ALDH / CD133 / 乳がん幹細胞 / 低酸素 / 血管新生 / VEGF / 抗癌剤 / G-蛋白質 / 活性酸素 Less

生体高分子認識構造α-solenoidを標的とした中分子創薬の基盤構築Principal Investigator
- Principal Investigator
  
  西谷直之
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Iwate Medical University
Development of a new macrolide derivative targeting mTORCPrincipal Investigator
- Principal Investigator
  
  Nishiya Naoyuki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Iwate Medical University
Development of A- and F-ring-modified lamellarin type inhibitors effective for C797S mutated EGFR
- Principal Investigator
  
  Fukuda Tsutomu
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 37020:Chemistry and chemical methodology of biomolecules-related
- Research Institution
  Nagasaki University
Drug discovery for targeting an mTORC componentPrincipal Investigator
- Principal Investigator
  
  Nishiya Naoyuki
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Iwate Medical University
Approach of production of dental epithelial cells from periodontal ligament mesenchymal cells for tooth regeneration
- Principal Investigator
  
  Harada Hidemitsu
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Dental engineering/Regenerative dentistry
- Research Institution
  Iwate Medical University
Development of EGFR-Tyrosine Kinase Inhibitors Effective for Non-Small Cell Lung Cancer Resistant to Gefitinib
- Principal Investigator
  
  IWAO Masatomo
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Nagasaki University
Molecular action mechanisms of chemical compounds that induce non-proteasomal degradation of beta-cateninPrincipal Investigator
- Principal Investigator
  
  Nishiya Naoyuki
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Iwate Medical University
Study of inhibitors and characterization of naturally occurring spheroids from monolayer culture
- Principal Investigator
  
  UEHARA YOSHIMASA
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Clinical oncology
- Research Institution
  Iwate Medical University
Elucidation of the action mechanism of Wnt pathway inhibitors by vertebrate chemical geneticsPrincipal Investigator
- Principal Investigator
  
  NISHIYA Naoyuki
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Iwate Medical University
がん抑制遺伝子産物TSLC1による膜輸送制御とその細胞増殖抑制への意義の解析Principal Investigator
- Principal Investigator
  
  西谷直之
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Iwate Medical University
細胞接着斑蛋白質Hic-5によるがん細胞形質の調節機構
- Principal Investigator
  
  柴沼質子
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Showa University
細胞老化関連遺伝子を標的とした新規抗がん剤の探索
- Principal Investigator
  
  野瀬清
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Showa University
integrinの細胞増殖制御におけるHic-5の機能Principal Investigator
- Principal Investigator
  
  西谷直之
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Showa University
Redox regulation of cell adhesion signals
- Principal Investigator
  
  NOSE Kiyoshi
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Showa University
細胞接着斑蛋白質Hic-5によるがん細胞形質の調節機構
- Principal Investigator
  
  柴沼質子
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Showa University
増殖制御遺伝子エンハンサーを用いた抗がん剤の探索
- Principal Investigator
  
  野瀬清
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Showa University
細胞接着斑蛋白質Hic-5の細胞老化、がん化における役割
- Principal Investigator
  
  NOSE Kiyoshi
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Showa University
新規細胞接着斑蛋白質HIC-5によるマクロファージ機能の制御機構Principal Investigator
- Principal Investigator
  
  西谷直之
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Biological pharmacy
- Research Institution
  Showa University
Regulation of adhesion signals by a focal adhesion protein, Hie5.
- Principal Investigator
  
  SHIBANUMA Motoko
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  SHOWA UNIVERSITY
ANALYSIS OF CYTOPLASMIC FACTORS THAT PARTICIPATE IN GROWTH ARREST INDUCED BY OXIDATIVE STRESS
- Principal Investigator
  
  NOSE Kiyoshi
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Biological pharmacy
- Research Institution
  SHOWA UNIVERSITY

[Journal Article] 中分子化合物の新たな標的分子：PI3K関連キナーゼのco-chaperone成分TELO22023
- Author(s)
  西谷直之、米澤穂波
- Journal Title
  
  Farumashia
  
  Volume: 59 Issue: 12 Pages: 1096-1100
- DOI
  10.14894/faruawpsj.59.12_1096
- ISSN
  0014-8601, 2189-7026
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-21K07182
[Journal Article] Ivermectin represses Wnt/β-catenin signaling by binding to TELO2, a regulator of phosphatidylinositol 3-kinase-related kinases2022
- Author(s)
  Yonezawa Honami、Ikeda Akari、Takahashi Ryo、Endo Haruka、Sugawara Yasuyo、Goto Mikako、Kanno Mirute、Ogawa Sosuke、Nakamura Karin、Ujiie Haruki、Iwatsuki Masato、Hirose Tomoyasu、Sunazuka Toshiaki、Uehara Yoshimasa、Nishiya Naoyuki
- Journal Title
  
  iScience
  
  Volume: 25 Issue: 3 Pages: 103912-103912
- DOI
  10.1016/j.isci.2022.103912
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07182, KAKENHI-PROJECT-22K06535
[Journal Article] Lamellarin 14, a derivative of marine alkaloids, inhibits the T790M/C797S mutant epidermal growth factor receptor2021
- Author(s)
  Nishiya Naoyuki、Oku Yusuke、Ishikawa Chie、Fukuda Tsutomu、Dan Shingo、Mashima Tetsuo、Ushijima Masaru、Furukawa Yoko、Sasaki Yuka、Otsu Keishi、Sakyo Tomoko、Abe Masanori、Yonezawa Honami、Ishibashi Fumito、Matsuura Masaaki、Tomida Akihiro、Seimiya Hiroyuki、Yamori Takao、Iwao Masatomo、Uehara Yoshimasa
- Journal Title
  
  Cancer Science
  
  Volume: － Issue: 5 Pages: 1963-1974
- DOI
  10.1111/cas.14839
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K05715, KAKENHI-PUBLICLY-20H04789, KAKENHI-PROJECT-18K09526, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-20K21555, KAKENHI-PROJECT-19H01806, KAKENHI-PROJECT-19H03523, KAKENHI-PROJECT-19H03526, KAKENHI-PROJECT-21K07251
[Journal Article] Synthesis and evaluation of azalamellarin N and its A-ring-modified analogues as non-covalent inhibitors of the EGFR T790M/L858R mutant2021
- Author(s)
  Fukuda Tsutomu、Anzai Mizuho、Nakahara Akane、Yamashita Kentaro、Matsukura Kazuaki、Ishibashi Fumito、Oku Yusuke、Nishiya Naoyuki、Uehara Yoshimasa、Iwao Masatomo
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 34 Pages: 116039-116039
- DOI
  10.1016/j.bmc.2021.116039
- NAID
  120006980722
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K05715, KAKENHI-PROJECT-16H06276
[Journal Article] IMU1003, an atrarate derivative, inhibits Wnt/β-catenin signaling2020
- Author(s)
  Yonezawa Honami、Sugawara Aoi、Sakyo Tomoko、Uehara Yoshimasa、Kawano Tomikazu、Nishiya Naoyuki
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 532 Issue: 3 Pages: 440-445
- DOI
  10.1016/j.bbrc.2020.08.031
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07329
[Journal Article] Clotrimazole inhibits the Wnt/β-catenin pathway by activating two eIF2α kinases: The heme-regulated translational inhibitor and the double-stranded RNA-induced protein kinase2018
- Author(s)
  Honami Yonezawa, Mami Ogawa, Sota Katayama, Yui Shimizu, Norikazu Omori, Yusuke Oku, Tomoko Sakyo, Yoshimasa Uehara, Naoyuki Nishiya
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 506 Issue: 1 Pages: 183-188
- DOI
  10.1016/j.bbrc.2018.10.053
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07329
[Journal Article] Chemical modifier screenings as methods for identifying pathway-targeting compounds and for predicting drug-drug interactions.2014
- Author(s)
  Nishiya, N.
- Journal Title
  
  Organic Chem. Curr. Res.
  
  Volume: 3 Issue: 02
- DOI
  10.4172/2161-0401.1000128
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25460069
[Journal Article] A zebrafish chemical suppressor screening identifies small molecule inhibitors of the Wnt/β-catenin pathway.2014
- Author(s)
  Nishiya N, Oku Y, Kumagai Y, Sato Y, Yamaguchi E, Sasaki A, Shoji M, Ohnishi Y, Okamoto H, Uehara Y.
- Journal Title
  
  Chem. Biol.
  
  Volume: 21 Issue: 4 Pages: 530-540
- DOI
  10.1016/j.chembiol.2014.02.015
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-23120008, KAKENHI-PROJECT-23501310, KAKENHI-PROJECT-25460069, KAKENHI-PROJECT-221S0001
[Journal Article] Multimodal Effects of Small Molecule ROCK and LIMK Inhibitors on Mitosis, and Their Implication as Anti-Leukemia Agents.,2014
- Author(s)
  Oku Y, Tareyanagi C, Takaya S, Osaka S, Ujiie H, Yoshida K, Nishiya N, Uehara Y.
- Journal Title
  
  PLoS One
  
  Volume: 9 Issue: 3 Pages: e92402-e92402
- DOI
  10.1371/journal.pone.0092402
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23501310, KAKENHI-PROJECT-25460069, KAKENHI-PROJECT-221S0001
[Journal Article] Identification of LY83583 as a specific inhibitor of Candida albicans MPS1 protein kinase.2011
- Author(s)
  Tsuda K, Nishiya N, Umeyama T and Uehara Y.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 409 Pages: 418-423
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23501310
[Journal Article] Identification of LY83583 as a specific inhibitor of Candida albicans MPS1 protein kinase2011
- Author(s)
  Tsuda K, Nishiya N, Umeyama T and Uehara Y.
- Journal Title
  
  Biochem. Biophys. Res . Commun
  
  Volume: 409 Pages: 418-423
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790082
[Journal Article] Identification of LY83583 as a specific inhibitor of Candida albicans MPS1 protein kinas2011
- Author(s)
  Tsuda K, Nishiya N, Umeyama T, Uehara Y
- Journal Title
  
  Biochem. Biophys. Res. Commun
  
  Volume: 409 Issue: 3 Pages: 418-423
- DOI
  10.1016/j.bbrc.2011.05.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22780079, KAKENHI-PROJECT-23501310
[Patent] Ｗｎｔシグナル阻害2014
- Inventor(s)
  西谷直之、上原至雅
- Industrial Property Rights Holder
  西谷直之、上原至雅
- Industrial Property Rights Type
  特許
- Filing Date
  2014-07-04
- Overseas
- Data Source
  KAKENHI-PROJECT-25460069
[Patent] Ｗｎｔシグナル阻害剤2013
- Inventor(s)
  西谷直之、上原至雅
- Industrial Property Rights Holder
  西谷直之、上原至雅
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2013-141555
- Filing Date
  2013-07-05
- Data Source
  KAKENHI-PROJECT-25460069
[Patent] Wntシグナル阻害剤2013
- Inventor(s)
  西谷直之、上原至雅
- Industrial Property Rights Holder
  西谷直之、上原至雅
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2013-141555
- Filing Date
  2013-07-05
- Data Source
  KAKENHI-PROJECT-23501310
[Patent] 胚の発生および／または分化を制御する方法2012
- Inventor(s)
  西谷直之　、河野富一、　畠中稔、　上原至雅
- Industrial Property Rights Holder
  西谷直之　、河野富一、　畠中稔、　上原至雅
- Industrial Property Number
  2011-041262
- Filing Date
  2012
- Data Source
  KAKENHI-PROJECT-23501310
[Patent] 胚の発生および/または分化を制御する方法2012
- Inventor(s)
  西谷直之、河野富一、畠中稔、上原至雅
- Industrial Property Rights Holder
  西谷直之、河野富一、畠中稔、上原至雅
- Industrial Property Rights Type
  特許
- Filing Date
  2012-03-13
- Overseas
- Data Source
  KAKENHI-PROJECT-23501310
[Patent] 産業財産権の名称：胚の発生および／または分化を制御する方法2012
- Inventor(s)
  西谷直之　、河野富一、　畠中稔、　上原至雅
- Industrial Property Rights Holder
  西谷直之　、河野富一、　畠中稔、　上原至雅
- Filing Date
  2012
- Overseas
- Data Source
  KAKENHI-PROJECT-23501310
[Patent] 胚の発生および/または分化を制御する方法2012
- Inventor(s)
  西谷直之、河野富一、畠中稔、上原至雅
- Industrial Property Rights Holder
  西谷直之、河野富一、畠中稔、上原至雅
- Filing Date
  2012-03-14
- Overseas
- Data Source
  KAKENHI-PROJECT-22790082
[Patent] 胚の発生および/または分化を制御する方法2012
- Inventor(s)
  西谷直之、河野富一、畠中稔、上原至雅
- Industrial Property Rights Holder
  西谷直之、河野富一、畠中稔、上原至雅
- Filing Date
  2012-03-14
- Overseas
- Data Source
  KAKENHI-PROJECT-22790082
[Patent] 胚の発生および/または分化を制御する方法2011
- Inventor(s)
  西谷直之、河野富一、畠中稔、上原至雅
- Industrial Property Rights Holder
  西谷直之、河野富一、畠中稔、上原至雅
- Industrial Property Number
  2011-041262
- Filing Date
  2011-02-28
- Data Source
  KAKENHI-PROJECT-22790082
[Patent] 胚の発生および/または分化を制御する方法2011
- Inventor(s)
  西谷直之、河野富一、畠中稔、上原至雅
- Industrial Property Rights Holder
  西谷直之、河野富一、畠中稔、上原至雅
- Industrial Property Number
  2011-041262
- Filing Date
  2011-02-28
- Data Source
  KAKENHI-PROJECT-22790082
[Presentation] PIKKs安定化因子TELO2はイベルメクチンによるWnt/β-catenin経路阻害作用を仲介する2023
- Author(s)
  米澤穂波、池田朱里、高橋亮、廣瀬友靖、岩月正人、砂塚敏明、上原至雅、西谷直之
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-21K07182
[Presentation] A chemical suppressor screening in zebrafish identifies Wnt/β-catenin pathway inhibitors improving anticancer drug response.2023
- Author(s)
  Naoyuki Nishiya, Honami Yonezawa
- Organizer
  EACR conference Cellular Bases for Patient Response to Cancer Therapies
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07182
[Presentation] Suppression of TELO2 inhibits survival of malignant rhabdoid tumor cells.2023
- Author(s)
  米澤穂波、氏家悠貴、上原至雅、西谷直之
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K07182
[Presentation] Trans-scale Pharmacology Identified TELO2 as a Target Molecule for a Wnt/β-catenin Pathway Inhibitor.2023
- Author(s)
  Naoyuki Nishiya, Haruki Ujiie, Honami Yonezawa.
- Organizer
  EMBO-COB Workshop "Trans-Scale Biology using exotic non-model organisms”
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07182
[Presentation] TELO2, a regulator of phosphatidylinositol 3-kinase-related kinases, is a druggable target for an inhibitor of the Wnt/β-catenin and the mTOR signaling2023
- Author(s)
  Honami Yonezawa, Haruki Ujiie, Yoshimasa Uehara, Naoyuki Nishiya
- Organizer
  EACR conference Cellular Bases for Patient Response to Cancer Therapies
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07182
[Presentation] PIKKs安定化因子TELO2の機能制御による悪性ラブドイド腫瘍細胞の増殖抑制2023
- Author(s)
  米澤穂波、上原至雅、西谷直之
- Organizer
  第27回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-21K07182
[Presentation] Targeting of TELO2 suppresses functions of PI3K-related kinases and the Wnt/β-catenin pathway.2022
- Author(s)
  西谷直之、米澤穂波、氏家悠貴、上原至雅
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K07182
[Presentation] TELO2へのイベルメクチンの結合はPI3K関連キナーゼ機能を制御する2022
- Author(s)
  西谷直之、米澤穂波、氏家悠貴、上原至雅
- Organizer
  第26回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-21K07182
[Presentation] Ivermectin-binding to TELO2 mediates the Wnt/beta-catenin signaling suppression by ivermectin.2022
- Author(s)
  米澤穂波、氏家悠貴、上原至雅、西谷直之
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K07182
[Presentation] 新規創薬標的分子TELO2を介したイベルメクチンによるWnt/β-catenin経路阻害作用の解析2022
- Author(s)
  米澤穂波、氏家悠貴、上原至雅、西谷直之
- Organizer
  第26回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-21K07182
[Presentation] ゼブラフィッシュ胚の表現型ダイバーシティーを利用したケミカルバイオロジー2021
- Author(s)
  西谷直之
- Organizer
  新学術領域「細胞ダイバース」公開シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-21K07182
[Presentation] IvBP mediates Wnt/beta-catenin signaling inhibitory activities of ivermectin2021
- Author(s)
  米澤穂波、上原至雅、西谷直之
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K07182
[Presentation] 高い抗がん選択性を持つ新規合成ラメラリン類縁体 Azalam 4 の抗がん作用様式の解析2021
- Author(s)
  大橋愛美, 福田勉, 岡村睦美, 西谷直之, 岩尾正倫, 旦慎吾
- Organizer
  第25回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-19K05715
[Presentation] pan-CDK阻害活性を示す新規合成ラメラリン類縁体Azalam 4の細胞特異的なアポトーシス誘導作用2021
- Author(s)
  大橋愛美, 福田勉, 岡村睦美, 西谷直之, 岩尾正倫, 旦慎吾
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K05715
[Presentation] 強い抗がん選択性を持つ新規合成ラメラリン類縁体 Azalam4の抗がんメカニズム解析2020
- Author(s)
  大橋愛美, 福田勉, 岡村睦美, 西谷直之, 岩尾正倫, 旦慎吾
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K05715
[Presentation] イベルメクチンは新規治療標的分子IvBPを介してWnt/β-catenin経路を阻害する2020
- Author(s)
  米澤穂波、上原至雅、西谷直之
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K07329
[Presentation] イベルメクチンのWnt経路阻害作用を仲介する新規治療標的: IvBP2020
- Author(s)
  米澤穂波、池田朱里、高橋亮、廣瀬友靖、岩月正人、大村智、砂塚敏明、上原至雅、西谷直之
- Organizer
  第59回日本薬学会東北支部大会
- Data Source
  KAKENHI-PROJECT-18K07329
[Presentation] 強い抗がん特異性を示しCDKを阻害する新規ラメラリン類縁体Azalam4の同定2020
- Author(s)
  大橋愛美, 福田勉, 岡村睦美, 西谷直之, 岩尾正倫, 旦慎吾
- Organizer
  第24回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-19K05715
[Presentation] 薬剤耐性 EGFR T790M/C797S に対する lamellarin と cetuximab の併用効果2019
- Author(s)
  西谷直之, 佐京智子, 奥裕介, 福田勉, 旦慎吾, 矢守隆夫, 石橋郁人, 上原至雅, 岩尾正倫
- Organizer
  第23回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-19K05715
[Presentation] イベルメクチン結合タンパク質(IvBP)のWnt/beta-catenin経路阻害剤イベルメクチンへの結合様式の解析2019
- Author(s)
  米澤穂波、上原至雅、西谷直之
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K07329
[Presentation] 第3世代EGFRチロシンキナーゼ阻害薬耐性非小細胞肺癌に対するLamellarin14とCetuximab併用効果の検討2019
- Author(s)
  阿部壮矩, 渡辺菜美, 佐京智子, 奥裕介, 福田勉, 旦慎吾, 矢守隆夫, 石橋郁人, 上原至雅, 岩尾正倫, 西谷直之
- Organizer
  第58回日本薬学会東北支部大会
- Data Source
  KAKENHI-PROJECT-19K05715
[Presentation] イベルメクチン結合タンパク質(IvBP)はdruggableなWnt/β-catenin経路仲介因子である2019
- Author(s)
  米澤穂波、池田朱里、高橋亮、廣瀬友靖、岩月正人、大村智、砂塚敏明、上原至雅、西谷直之
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-18K07329
[Presentation] イベルメクチン結合タンパク質の同定とそのWnt/beta-catenin経路への関与2019
- Author(s)
  米澤穂波、上原至雅、西谷直之
- Organizer
  第23回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07329
[Presentation] イベルメクチン結合タンパク質によるWnt/beta-catenin経路の制御2019
- Author(s)
  米澤穂波、上原至雅、西谷直之
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-18K07329
[Presentation] ゼブラフィッシュ表現型解析によるがん分子標的治療における諸問題への挑戦2019
- Author(s)
  西谷直之
- Organizer
  愛媛大学医学研究科　プロテオセミナー
- Invited
- Data Source
  KAKENHI-PROJECT-18K07329
[Presentation] ゼブラフィッシュ表現型を利用した化合物スクリーニングと毒性評価2019
- Author(s)
  西谷直之
- Organizer
  日本学術振興会　アカデミアとインダストリーをつなぐ委員会
- Invited
- Data Source
  KAKENHI-PROJECT-18K07329
[Presentation] 強い抗がん選択性を持つCDK4/6を標的とした新規ラメラリン類縁体の同定2019
- Author(s)
  大橋愛美, 福田勉, 岡村睦美, 西谷直之, 宇野佑子, 澤匡明, 岩尾正倫, 旦慎吾
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K05715
[Presentation] ゼブラフィッシュ表現型を利用したケミカルサプレッサー探索系2019
- Author(s)
  西谷直之
- Organizer
  第10回スクリーニング学研究会
- Data Source
  KAKENHI-PROJECT-18K07329
[Presentation] A zebrafish phenotypic screening re-discovered ivermectin as a Wnt pathway inhibitor.2019
- Author(s)
  西谷直之、米澤穂波、池田朱里、高橋亮、廣瀬友靖、砂塚敏明、大村智、上原至雅
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K07329
[Presentation] アゾール系抗真菌薬によるWnt/beta-catenin経路阻害と抗腫瘍作用2018
- Author(s)
  米澤穂波、大森紀和、小川真実、片山綜太、清水優依、西谷直之
- Organizer
  日本生化学会東北支部第84回例会・シンポジウム
- Data Source
  KAKENHI-PROJECT-18K07329
[Presentation] Identifying chemical suppressors of the Wnt/β-catenin signaling pathway.2018
- Author(s)
  Naoyuki Nishiya
- Organizer
  Yonsei Biomedical Dialogue 2018
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07329
[Presentation] Ivermectin suppresses the Wnt/beta-catenin pathway and specifically binds to target proteins.2018
- Author(s)
  Honami Yonezawa, Yoshimasa Uehara, Naoyuki Nishiya
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K07329
[Presentation] Chemical suppressors of the Wnt/β-catenin signaling pathway and their molecular targets2018
- Author(s)
  Naoyuki Nishiya, Honami Yonezawa, Tomoko Sakyo
- Organizer
  2018 The 6th Tripartite Conference on Tooth and Bone in Development & Regeneration
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07329
[Presentation] Self-floating cell populations express breast cancer stem cell markers and show resistance to anticancer drugs.2016
- Author(s)
  (58)Uehara, Y., Oku, Y., Tsuda, K., Shibazaki, M., Maesawa, C., Nishiya, N.
- Organizer
  AACR-JCA Joint Conference
- Place of Presentation
  Maui (USA)
- Year and Date
  2016-02-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460069
[Presentation] Wnt/β-catenin経路に対するケミカルサプレッサーの探索2016
- Author(s)
  西谷直之
- Organizer
  第136年会日本薬学会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-03-26
- Invited
- Data Source
  KAKENHI-PROJECT-25460069
[Presentation] アゾール系抗真菌薬によるWnt/β -catenin経路阻害作用2015
- Author(s)
  西谷直之、片山綜太、清水優依、小川真実、工藤紫乃、堀籠宏稀、奥　裕介、上原至雅
- Organizer
  第135年会日本薬学会
- Place of Presentation
  兵庫医療大学（兵庫県・神戸市）
- Year and Date
  2015-03-26
- Data Source
  KAKENHI-PROJECT-25460069
[Presentation] An antiparasitic ivermectin inhibits Wnt/beta-catenin signaling and blocks proliferation of colorectal cancer cells.2015
- Author(s)
  Nishiya, N., Oku, Y., Uehara, Y.
- Organizer
  日本癌学会　第74回総会
- Place of Presentation
  名古屋国際会議場　（愛知県名古屋市）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-25460069
[Presentation] Wntシグナル阻害活性を有するアリールプロピン酸誘導体の合成と構造活性相関2015
- Author(s)
  河野富一，西谷直之
- Organizer
  第33回メディシナルケミストリーシンポジウム
- Place of Presentation
  幕張国際研修センター　（千葉県千葉市）
- Year and Date
  2015-11-25
- Data Source
  KAKENHI-PROJECT-25460069
[Presentation] アゾール系抗真菌薬によるWnt/beta-catenin経路阻害を介した抗腫瘍活性2015
- Author(s)
  西谷直之、奥　裕介、上原至雅
- Organizer
  第19回日本がん分子標的治療学会学術集会
- Place of Presentation
  松山全日空ホテル（愛媛県松山市）
- Year and Date
  2015-06-10
- Data Source
  KAKENHI-PROJECT-25460069
[Presentation] アゾール系抗真菌薬によるWnt/beta-catenin経路阻害の作用機序の解析2015
- Author(s)
  (52)小川真実、片山綜太、清水優依、奥　裕介、上原至雅、西谷直之
- Organizer
  第54回日本薬学会東北支部大会
- Place of Presentation
  岩手医科大学矢巾キャンパス（岩手県紫波郡矢巾町）
- Year and Date
  2015-09-26
- Data Source
  KAKENHI-PROJECT-25460069
[Presentation] (48)Nishiya, N., Oku, Y., Uehara, Y. Self-floating breast cancer cells elevate aldehyde dehydrogenase activity and show drug resistance.2015
- Author(s)
  Nishiya, N., Oku, Y., Uehara, Y.
- Organizer
  2015 Annual Meeting of the International Society for Stem Cell Research
- Place of Presentation
  Stockholm　（Sweden）
- Year and Date
  2015-06-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460069
[Presentation] ゼブラフィッシュの化学遺伝学を利用した抗がん剤シード探索と毒性予測2015
- Author(s)
  西谷直之
- Organizer
  日本農芸化学会2015年度大会　シンポジウム　「異分野融合による天然物創薬～生理活性物質から医薬品シーズへ～」
- Place of Presentation
  岡山大学津島キャンパス（岡山県・岡山市）
- Year and Date
  2015-03-29
- Invited
- Data Source
  KAKENHI-PROJECT-25460069
[Presentation] がん幹細胞様細胞集団を濃縮する自発的浮遊培養法2015
- Author(s)
  奥　裕介、西谷直之、上原至雅
- Organizer
  第54回日本薬学会東北支部大会
- Place of Presentation
  岩手医科大学矢巾キャンパス（岩手県紫波郡矢巾町）
- Year and Date
  2015-09-26
- Data Source
  KAKENHI-PROJECT-25460069
[Presentation] イベルメクチンによるWnt/beta-catenin経路の阻害とその作用機序の解析2015
- Author(s)
  工藤紫乃、堀籠宏稀、奥　裕介、上原至雅、西谷直之
- Organizer
  第54回日本薬学会東北支部大会
- Place of Presentation
  岩手医科大学矢巾キャンパス（岩手県紫波郡矢巾町）
- Year and Date
  2015-09-26
- Data Source
  KAKENHI-PROJECT-25460069
[Presentation] Self-floating cell populations express cancer stem markers and show resistance to anticancer drugs.2015
- Author(s)
  Oku, Y., Nishiya, N., Uehara, Y.
- Organizer
  日本癌学会　第74回総会
- Place of Presentation
  名古屋国際会議場　（愛知県名古屋市）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-25460069
[Presentation] アゾール系抗真菌薬によるWnt/β-catenin経路への阻害効果2014
- Author(s)
  西谷直之、奥　裕介、上原至雅
- Organizer
  第18回日本がん分子標的治療学会学術集会
- Place of Presentation
  仙台市情報・産業プラザ（宮城県・仙台市）
- Year and Date
  2014-06-26
- Data Source
  KAKENHI-PROJECT-25460069
[Presentation] タンパク質脂質修飾酵素によるWnt/β-cateninシグナルの制御2014
- Author(s)
  西谷直之、奥　裕介　上原至雅
- Organizer
  化学療法基盤支援活動第3回シンポジウム
- Place of Presentation
  万国津梁館（沖縄県・名護市）
- Year and Date
  2014-05-12
- Data Source
  KAKENHI-PROJECT-25460069
[Presentation] A zebrafish chemichal suppressor screening identifys antifungal azoles as inhibitors of the Wnt/beta-catenin pathway.2014
- Author(s)
  Nishiya, N., Oku, Y., Uehara, Y.
- Organizer
  日本癌学会　第72回総会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2014-09-25
- Data Source
  KAKENHI-PROJECT-25460069
[Presentation] アゾール系抗真菌薬によるWnt/β-catenin シグナル抑制作用2014
- Author(s)
  西谷直之
- Organizer
  BIO tech 2014　アカデミックフォ－ラム
- Place of Presentation
  東京ビッグサイト（東京都・江東区）
- Year and Date
  2014-05-16
- Data Source
  KAKENHI-PROJECT-25460069
[Presentation] 化学療法基盤支援活動「プロテインキナーゼ (PK) 阻害活性の評価」2014
- Author(s)
  西谷直之, 岩尾正倫, 上原至雅
- Organizer
  文科省新学術領域研究・がん支援「化学療法基盤支援活動」第３回シンポジウム　アカデミアからの抗がん剤創薬に向けて　天然物の有効利用
- Place of Presentation
  万国津梁館 (沖縄県名護市)
- Year and Date
  2014-05-12
- Invited
- Data Source
  KAKENHI-PROJECT-26293028
[Presentation] ゼブラフィッシュを用いた化学遺伝学と毒性予測2014
- Author(s)
  西谷直之
- Organizer
  第46回日本臨床検査医学会東北支部総会・第25回日本臨床化学会東北支部総会（合同開催）
- Place of Presentation
  岩手医科大学内丸キャンパス（岩手県・盛岡市）
- Year and Date
  2014-08-09
- Invited
- Data Source
  KAKENHI-PROJECT-25460069
[Presentation] Geranylgeranyltransferase inhibitors attenuate the Wnt/beta-catenin signaling pathway2013
- Author(s)
  Nishiya, N., Abe, S., Iwaoka, S., Ohmori, N., Ohnishi, Y., Sasaki, A., Shoji, M., Oku, Y, Uehara, Y.
- Organizer
  FAOBMB mini symposium 2013
- Place of Presentation
  矢巾
- Year and Date
  2013-04-06
- Data Source
  KAKENHI-PROJECT-23501310
[Presentation] Geranylgeranyltransferase inhibitors attenuate the Wnt/beta-catenin signaling pathway.2013
- Author(s)
  ○西谷直之、阿部早織、岩岡ささの、大森紀和、大西亨美、佐々木朱里、庄司桃子、奥裕介、上原至雅
- Organizer
  FAOBMB mini symposium 2013
- Place of Presentation
  岩手医科大学
- Data Source
  KAKENHI-PROJECT-23501310
[Presentation] 上原至雅Wnt/β-catenin経路阻害活性をもつGGTI-286の作用機序の解析2013
- Author(s)
  大森紀和、阿部早織、岩岡ささの、大西亨美、佐々木朱里、庄司桃子、奥裕介、西谷直之
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜
- Year and Date
  2013-03-28
- Data Source
  KAKENHI-PROJECT-22790082
[Presentation] ROCK-LIMK1はAurora A を活性化し、中心体の恒常性維持に寄与する2013
- Author(s)
  奥裕介、西谷直之、上原至雅
- Organizer
  第17回日本がん分子標的治療学会学術集会
- Place of Presentation
  京都
- Year and Date
  2013-06-13
- Data Source
  KAKENHI-PROJECT-23501310
[Presentation] A phenotype-based screening for chemical suppressors of the Wnt/beta-catenin pathway in zebrafish2013
- Author(s)
  Nishiya, N., Kawano, T., and Uehara, Y.
- Organizer
  The 18th Japanese Foundation for Cancer Research-International Symposium on Cancer Chemotherapy
- Place of Presentation
  Tokyo
- Invited
- Data Source
  KAKENHI-PROJECT-25460069
[Presentation] ゼブラフィッシュ胚を用いたWnt/β-catenin経路ケミカルサプレッサーの探索2013
- Author(s)
  ○ 西谷直之、河野富一、上原至雅
- Organizer
  日本薬学会生薬天然物部会主催・第5回食品薬学シンポジウム
- Place of Presentation
  京都大学
- Invited
- Data Source
  KAKENHI-PROJECT-23501310
[Presentation] ROCK-LIMK1はAurora Aを活性化し、中心体の恒常性維持に寄与する2013
- Author(s)
  ○奥　裕介、西谷直之、上原至雅
- Organizer
  第17回日本がん分子標的治療学会学術集会
- Place of Presentation
  国立京都国際会館
- Data Source
  KAKENHI-PROJECT-23501310
[Presentation] がん細胞と微小環境との相互作用の薬理学的制御2013
- Author(s)
  上原至雅、奥裕介、西谷直之
- Organizer
  日本農芸化学会2013年度大会シンポジウム「細胞骨格とシグナル伝達の理解からがんに迫る」
- Place of Presentation
  仙台
- Year and Date
  2013-03-27
- Data Source
  KAKENHI-PROJECT-23501310
[Presentation] A phenotype-based screening for chemical suppressors of the Wnt/beta-catenin pathway in zebrafish2013
- Author(s)
  Nishiya, N., Kawano, T., and Uehara, Y.
- Organizer
  The 18th Japanese Foundation for Cancer Research-International Symposium on Cancer Chemotherapy,
- Place of Presentation
  未来館（東京）
- Invited
- Data Source
  KAKENHI-PROJECT-23501310
[Presentation] Geranylgeranyltransferase inhibitors attenuate the Wnt/beta-catenin signaling pathway.2013
- Author(s)
  Nishiya, N.
- Organizer
  FAOBMB mini symposium 2013
- Place of Presentation
  矢巾
- Data Source
  KAKENHI-PROJECT-22790082
[Presentation] がん細胞と微小環境との相互作用の薬理学的制御2013
- Author(s)
  上原至雅、奥裕介、西谷直之
- Organizer
  日本農芸化学会2013年度大会シンポジウム「細胞骨格とシグナル伝達の理解からがんに迫る」
- Place of Presentation
  仙台
- Year and Date
  2013-03-27
- Data Source
  KAKENHI-PROJECT-22790082
[Presentation] Geranylgeranyltransferase as a potential molecular target for Wnt/beta-catenin pathway inhibitors2013
- Author(s)
  Nishiya, N., Oku, Y., Uehara, Y.
- Organizer
  日本癌学会第72回総会
- Place of Presentation
  横浜
- Year and Date
  2013-10-03
- Data Source
  KAKENHI-PROJECT-23501310
[Presentation] ゼブラフィッシュ胚を用いたWnt/β-catenin 経路ケミカルサプレッサーの探索2013
- Author(s)
  西谷直之、河野富一、上原至雅
- Organizer
  日本薬学会生薬天然物部会主催・第5回食品薬学シンポジウム
- Place of Presentation
  京都
- Year and Date
  2013-11-02
- Invited
- Data Source
  KAKENHI-PROJECT-23501310
[Presentation] ゲラニルゲラニルトランスフェラーゼ阻害剤によるβ-catenin核移行の阻害2013
- Author(s)
  ○西谷直之、奥　裕介、上原至雅
- Organizer
  第17回日本がん分子標的治療学会学術集会
- Place of Presentation
  国立京都国際会館
- Data Source
  KAKENHI-PROJECT-23501310
[Presentation] ゲラニルゲラニルトランスフェラーゼ阻害剤によるβ-catenin 核移行の阻害2013
- Author(s)
  西谷直之、奥裕介、上原至雅
- Organizer
  第17回日本がん分子標的治療学会学術集会
- Place of Presentation
  京都
- Year and Date
  2013-06-13
- Data Source
  KAKENHI-PROJECT-23501310
[Presentation] ROCK-LIMK1 axis activates Aurora A and participates in centrosome integrity.2013
- Author(s)
  ○奥裕介、垂柳智秋、氏家悠貴、高谷真一、吉田健太郎、西谷直之、上原至雅
- Organizer
  FAOBMB mini symposium 2013
- Place of Presentation
  岩手医科大学
- Data Source
  KAKENHI-PROJECT-23501310
[Presentation] A phenotype-based screening for chemical suppressors of the Wnt/beta-catenin pathway in zebrafish2013
- Author(s)
  Nishiya, N., Kawano, T., Uehara, Y.
- Organizer
  The 18th Japanese Foundation for Cancer Research-International Symposium on Cancer Chemotherapy
- Place of Presentation
  Tokyo
- Year and Date
  2013-12-04
- Invited
- Data Source
  KAKENHI-PROJECT-23501310
[Presentation] Geranylgeranyltransferase as a potential molecular target for Wnt/beta-catenin pathway inhibitors2013
- Author(s)
  ○奥裕介、西谷直之、上原至雅
- Organizer
  日本癌学会　第72回総会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-23501310
[Presentation] Wnt/β-catenin 経路阻害活性をもつGGTI-286 の作用機序の解析2013
- Author(s)
  大森紀和、阿部早織、岩岡ささの、大西亨美、佐々木朱里、庄司桃子、奥裕介、西谷直之、上原至雅
- Organizer
  第132年会日本薬学会
- Place of Presentation
  横浜
- Year and Date
  2013-03-28
- Data Source
  KAKENHI-PROJECT-23501310
[Presentation] Rho-associated coiled coil kinase (ROCK)阻害剤による染色体不安定性の誘導2013
- Author(s)
  垂柳智秋、氏家悠貴、高谷真一、吉田健太郎、奥裕介、西谷直之、上原至雅
- Organizer
  第132年会日本薬学会
- Place of Presentation
  横浜
- Year and Date
  2013-03-28
- Data Source
  KAKENHI-PROJECT-23501310
[Presentation] ROCK-LIMK1 axis activates Aurora A and participates in centrosome integrity2013
- Author(s)
  Oku, Y., Tareyanagi, C., Ujiie, H., Takaya, S., Yoshida, K., Nishiya, N., Uehara, Y.
- Organizer
  FAOBMB mini symposium 2013
- Place of Presentation
  矢巾
- Year and Date
  2013-04-06
- Data Source
  KAKENHI-PROJECT-23501310
[Presentation] IMU14 derivatives as novel Wnt/ β-catenin signaling inhibitors2012
- Author(s)
  Nishiya, N., Kawano, T., Uehara、Y.
- Organizer
  日本癌学会第71回総会
- Place of Presentation
  札幌
- Year and Date
  2012-09-21
- Data Source
  KAKENHI-PROJECT-22790082
[Presentation] IMU14 derivatives as novel Wnt/beta-catenin signaling inhibitors.2012
- Author(s)
  西谷直之
- Organizer
  日本癌学会　第71回総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-22790082
[Presentation] タンパク質の脂質修飾制御による選択的Wnt/β-cateninシグナル阻害2012
- Author(s)
  西谷直之
- Organizer
  第16回日本がん分子標的治療学会学術集会
- Place of Presentation
  北九州
- Data Source
  KAKENHI-PROJECT-22790082
[Presentation] ゼブラフィッシュ胚を用いたWnt/β-catenin経路阻害剤探索系の構築2012
- Author(s)
  山口英美、熊谷裕介、佐藤佑樹、西谷直之、上原至雅
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Year and Date
  2012-03-29
- Data Source
  KAKENHI-PROJECT-22790082
[Presentation] 新規Wnt/β-cateninシグナル阻害剤IMU1003の同定2012
- Author(s)
  小松豊徳　三田地沙織　河野富一　西谷直之　上原至雅
- Organizer
  第132年会　日本薬学会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23501310
[Presentation] タンパク質脂質修飾による選択的Wnt/β-cateninシグナル制御2012
- Author(s)
  西谷直之, 奥裕介, 上原至雅
- Organizer
  未来医療開発プロジェクト研究成果発表会
- Place of Presentation
  岩手医科大学矢巾キャンパス
- Year and Date
  2012-08-09
- Data Source
  KAKENHI-PROJECT-23501310
[Presentation] 新規Wnt/β-catenin シグナル阻害剤IMU1003 の同定2012
- Author(s)
  小松豊徳、三田地沙織、河野富一、西谷直之、上原至雅
- Organizer
  第132年会日本薬学会
- Place of Presentation
  札幌
- Year and Date
  2012-03-29
- Data Source
  KAKENHI-PROJECT-23501310
[Presentation] カンジダMps1 キナーゼを標的とする新規抗真菌薬の探索2012
- Author(s)
  及川慎吾、加藤大器、今野拓哉、白鳥裕佳、森岡広記、吉池比香里、奥裕介、津田香代子、西谷直之、上原至雅
- Organizer
  第132年会日本薬学会
- Place of Presentation
  札幌
- Year and Date
  2012-03-29
- Data Source
  KAKENHI-PROJECT-23501310
[Presentation] ゼブラフィッシュ胚を用いたWnt/β-catenin 経路阻害剤探索系の構築2012
- Author(s)
  山口英美、熊谷裕介、佐藤佑樹、西谷直之、上原至雅
- Organizer
  第132年会日本薬学会
- Place of Presentation
  札幌
- Year and Date
  2012-03-29
- Data Source
  KAKENHI-PROJECT-23501310
[Presentation] 新規Wnt/β-cateninシグナル阻害剤IMU1003の同定2012
- Author(s)
  小松豊徳、三田地沙織、河野富一、西谷直之、上原至雅
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Year and Date
  2012-03-29
- Data Source
  KAKENHI-PROJECT-22790082
[Presentation] IMU14 derivatives as novel Wnt/beta-catenin signaling inhibitors2012
- Author(s)
  Nishiya, N., Kawano, T., Uehara、Y.
- Organizer
  日本癌学会第71回総会
- Place of Presentation
  札幌
- Year and Date
  2012-09-21
- Data Source
  KAKENHI-PROJECT-23501310
[Presentation] カンジダMps1キナーゼを標的とする新規抗真菌薬の探索2012
- Author(s)
  及川慎吾、加藤大器、今野拓哉、白鳥裕佳、森岡広記、吉池比香里、奥裕介、津田香代子、西谷直之、上原至雅
- Organizer
  第132年会　日本薬学会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23501310
[Presentation] 上原至雅ゼブラフィッシュ胚を用いたWnt/β-catenin 経路阻害剤探索系の構築2012
- Author(s)
  山口英美、熊谷裕介、佐藤佑樹、西谷直之
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Year and Date
  2012-03-29
- Data Source
  KAKENHI-PROJECT-22790082
[Presentation] ゼブラフィッシュ胚を用いたWnt/β-catenin 経路阻害剤探索系の構築2012
- Author(s)
  山口英美、熊谷裕介　佐藤佑樹　西谷直之　上原至雅
- Organizer
  第132年会　日本薬学会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23501310
[Presentation] タンパク質の脂質修飾制御による選択的Wnt/β-catenin シグナル阻害2012
- Author(s)
  西谷直之、奥裕介、上原至雅
- Organizer
  第16回日本がん分子標的治療学会学術集会
- Place of Presentation
  北九州
- Year and Date
  2012-06-29
- Data Source
  KAKENHI-PROJECT-23501310
[Presentation] タンパク質の脂質修飾制御による選択的Wnt/ β-cateninシグナル阻害2012
- Author(s)
  西谷直之、奥裕介、上原至雅
- Organizer
  第16回日本がん分子標的治療学会学術集会
- Place of Presentation
  北九州
- Year and Date
  2012-06-29
- Data Source
  KAKENHI-PROJECT-22790082
[Presentation] 新規Wnt/β-cateninシグナル阻害剤IMU1003の同定2012
- Author(s)
  小松豊徳、三田地沙織、河野富一、西谷直之、上原至雅
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Year and Date
  2012-03-29
- Data Source
  KAKENHI-PROJECT-22790082
[Presentation] ゼブラフィッシュ胚を用いたWnt/β-cateninシグナル阻害剤の探索2011
- Author(s)
  西谷直之、河野富一、津田香代子、上原至雅
- Organizer
  第15回学術集会　日本がん分子標的治療学会
- Place of Presentation
  港区台場
- Data Source
  KAKENHI-PROJECT-23501310
[Presentation] ゼブラフィッシュ胚を用いたWnt/β-カテニンシグナル阻害剤の探索2011
- Author(s)
  西谷直之、河野富一、津田香代子、上原至雅
- Organizer
  日本がん分子標的治療学会第15回学術集会
- Place of Presentation
  台場
- Year and Date
  2011-06-23
- Data Source
  KAKENHI-PROJECT-22790082
[Presentation] ゼブラフィッシュ胚を用いたWnt/β-cateninシグナル阻害剤の探索2011
- Author(s)
  西谷直之、河野富一、津田香代子、上原至雅
- Organizer
  日本がん分子標的治療学会第15回学術集会
- Place of Presentation
  台場
- Year and Date
  2011-06-23
- Data Source
  KAKENHI-PROJECT-22790082
[Presentation] ゼブラフィッシュ胚を用いたWnt/β-catenin シグナル阻害剤の探索2011
- Author(s)
  西谷直之、河野富一、津田香代子、上原至雅
- Organizer
  日本がん分子標的治療学会第15回学術集会
- Place of Presentation
  東京
- Year and Date
  2011-09-22
- Data Source
  KAKENHI-PROJECT-23501310
[Presentation] ゲフィチニブ耐性EGFR T790M変異の克服を志向したキナーゼ阻害剤プロファイリング2010
- Author(s)
  西谷直之、津田香代子、上原至雅
- Organizer
  日本がん分子標的治療学会第14回学術集会
- Place of Presentation
  江戸川区船堀
- Year and Date
  2010-07-08
- Data Source
  KAKENHI-PROJECT-22790082
[Presentation] ゼブラフィッシュ胚を用いたがん分子標的薬探索系の開発2009
- Author(s)
  西谷直之
- Organizer
  13回日本がん分子標的治療学会学術集会
- Place of Presentation
  徳島
- Year and Date
  2009-06-26
- Data Source
  KAKENHI-PROJECT-20790072
[Presentation] ARF-GAP結合性膜受容体の反発性ガイド機能と細胞間接着への関与2008
- Author(s)
  西谷直之
- Organizer
  第31回日本分子生物学会年会(BMB2008)
- Place of Presentation
  神戸
- Year and Date
  2008-12-12
- Data Source
  KAKENHI-PROJECT-20790072
[Presentation] 薬理学的Wntシグナル制御による胚発生および分化を制御する方法
- Author(s)
  西谷直之
- Organizer
  BIO tech 2013　アカデミックフォ－ラム
- Place of Presentation
  有明
- Data Source
  KAKENHI-PROJECT-25460069
[Presentation] IMU14 derivatives as novel Wnt/beta-catenin signaling inhibitors.
- Author(s)
  Nishiya, N., Kawano, T., Uehara、Y.
- Organizer
  日本癌学会　第71回総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23501310
[Presentation] ROCK-LIMK1 axis activates Aurora A and participates in centrosome integrity.
- Author(s)
  Oku, Y., Tareyanagi, C., Ujiie, H., Takaya, S., Yoshida, K., Nishiya, N., Uehara, Y.
- Organizer
  FAOBMB mini symposium 2013
- Place of Presentation
  紫波郡矢巾町
- Data Source
  KAKENHI-PROJECT-25460069
[Presentation] ゼブラフィッシュ胚を用いたWnt/β-catenin経路ケミカルサプレッサーの探索
- Author(s)
  西谷直之、河野富一、上原至雅
- Organizer
  日本薬学会生薬天然物部会主催・第5回食品薬学シンポジウム
- Place of Presentation
  京都
- Invited
- Data Source
  KAKENHI-PROJECT-25460069
[Presentation] がん細胞と微小環境との相互作用の薬理学的制御
- Author(s)
  上原至雅、奥裕介、西谷直之
- Organizer
  日本農芸化学会2013年度大会シンポジウム
- Place of Presentation
  仙台
- Invited
- Data Source
  KAKENHI-PROJECT-23501310
[Presentation] Geranylgeranyltransferase as a potential molecular target for Wnt/beta-catenin pathway inhibitors.
- Author(s)
  Nishiya, N., Oku, Y., Uehara, Y.
- Organizer
  日本癌学会　第72回総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-25460069
[Presentation] Rho-associated coiled coil kinase (ROCK)阻害剤による染色体不安定性の誘導
- Author(s)
  垂柳智秋、氏家悠貴、高谷真一、吉田健太郎、奥裕介、西谷直之、上原至雅
- Organizer
  132年会日本薬学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23501310
[Presentation] ROCK-LIMK1はAurora Aを活性化し、中心体の恒常性維持に寄与する
- Author(s)
  奥　裕介、西谷直之、上原至雅
- Organizer
  第17回日本がん分子標的治療学会学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-25460069
[Presentation] ゲラニルゲラニルトランスフェラーゼ阻害剤によるβ-catenin核移行の阻害
- Author(s)
  西谷直之、奥　裕介、上原至雅
- Organizer
  第17回日本がん分子標的治療学会学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-25460069
[Presentation] Wnt/β-catenin経路阻害活性をもつGGTI-286の作用機序の解析
- Author(s)
  大森紀和、阿部早織、岩岡ささの、大西亨美、佐々木朱里、庄司桃子、奥裕介、西谷直之、上原至雅
- Organizer
  132年会日本薬学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23501310
[Presentation] Geranylgeranyltransferase inhibitors attenuate the Wnt/beta-catenin signaling pathway.
- Author(s)
  Nishiya, N., Abe, S., Iwaoka, S., Ohmori, N., Ohnishi, Y., Sasaki, A., Shoji, M., Oku, Y, Uehara, Y.
- Organizer
  FAOBMB mini symposium 2013
- Place of Presentation
  紫波郡矢巾町
- Data Source
  KAKENHI-PROJECT-25460069
[Presentation] タンパク質の脂質修飾制御による選択的Wnt/β-cateninシグナル阻害
- Author(s)
  西谷直之、奥裕介、上原至雅
- Organizer
  第16回日本がん分子標的治療学会学術集会
- Place of Presentation
  北九州
- Data Source
  KAKENHI-PROJECT-23501310

1. SHIBANUMA Motoko (60245876)

# of Collaborated Projects: 8 results

# of Collaborated Products: 0 results
2. NOSE Kiyoshi (70012747)

# of Collaborated Projects: 7 results

# of Collaborated Products: 0 results
3. EGAWA Kiyoshi (00095879)

# of Collaborated Projects: 7 results

# of Collaborated Products: 0 results
4. MASHIMO Junn'ichi (60054045)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
5. 大場基 (70297018)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. UEHARA YOSHIMASA (50160213)

# of Collaborated Projects: 2 results

# of Collaborated Products: 36 results
7. Fukuda Tsutomu (80295097)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
8. 國元節子 (10161655)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. 大津圭史 (60509066)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. OKU Yusuke (50626843)

# of Collaborated Projects: 1 results

# of Collaborated Products: 22 results
11. KAWANO Tomikazu (30283807)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
12. MORI Kazunori (60349040)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. KIM-KANEYAMA Joori (10338535)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. Harada Hidemitsu (70271210)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. IWAO Masatomo (00100892)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
16. UNNO Hideaki (10452872)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 藤原尚樹 (20190100)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 石橋郁人 (10192486)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 廣瀬友靖 (00370156)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 梅山隆

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 岡本仁

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Nishiya Naoyuki 西谷 直之

NISHIYA Naoyuki 西谷 直之

Research Projects

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Co-Researchers

生体高分子認識構造α-solenoidを標的とした中分子創薬の基盤構築Principal Investigator

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Development of a new macrolide derivative targeting mTORCPrincipal Investigator

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Drug discovery for targeting an mTORC componentPrincipal Investigator

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Molecular action mechanisms of chemical compounds that induce non-proteasomal degradation of beta-cateninPrincipal Investigator

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Elucidation of the action mechanism of Wnt pathway inhibitors by vertebrate chemical geneticsPrincipal Investigator

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がん抑制遺伝子産物TSLC1による膜輸送制御とその細胞増殖抑制への意義の解析Principal Investigator

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integrinの細胞増殖制御におけるHic-5の機能Principal Investigator

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Nishiya Naoyuki 西谷直之

NISHIYA Naoyuki 西谷直之