Kasahara Jiro 笠原二郎

… Alternative Names

笠原二郎カサハラジロウ

KASAHARA Jiro 笠原二郎

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Researcher Number	10295131
Other IDs
Affiliation (Current)	2025: 徳島大学, 大学院医歯薬学研究部(薬学域), 准教授
Affiliation (based on the past Project Information) *help	2015 – 2016: 徳島大学, 大学院医歯薬学研究部, 准教授 2013 – 2014: 徳島大学, ヘルスバイオサイエンス研究部, 准教授 2009 – 2010: 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 准教授 2007 – 2009: Tohoku University, 大学院・薬学研究科, 講師 2004: Tohoku University, Graduate School of Pharmaceutical Sciences, Department of Pharmacology, Assistant Professor, 大学院・薬学研究科, 講師 2003: 東北大学, 大学院・薬学研究科, 助手 1997 – 2001: Kumamoto University School of Medicine, Pharmacology, Instructor, 医学部, 助手
Review Section/Research Field	Principal Investigator Experimental pathology / Neurochemistry/Neuropharmacology / Neurochemistry/Neuropharmacology Except Principal Investigator Neurochemistry/Neuropharmacology / General pharmacology / Biological Sciences / Physical pharmacy / Biological pharmacy / Applied pharmacology / Neurochemistry/Neuropharmacology
Keywords	Principal Investigator 海馬神経細胞 / リン酸化 / カルモデュリン / カルシウム / 神経再生 / カルシウムシグナル / ストレス / 疾患モデル動物 / うつ病 / 可塑性 … More / セロトニン / 抗うつ薬 / 神経新生 / うっ病モデル / 細胞内カルシウム / リン酸化反応 / モデル動物 / シグナル伝達 / 薬理学 / 脳神経疾患 / 活性測定 / CaM kinaswe I / CaM kinase kinase / 活性 / 細胞内局在 / 海馬 / ニューロン / プロテインキナーゼ / 細胞内情報伝達機構 / 脱リン酸化 / LTP / CA1 / CREB / カムキナーゼIV … More Except Principal Investigator CaMキナーゼII / カルモデュリン / MAPキナーゼ / 海馬 / NG108-15細胞 / CaM kinase II / long-term potentiation / カルシウム / 脳由来神経栄養因子 / 学習 / 長期増強 / シナプス可塑性 / カルシニューリン / プロテインホスファターゼ / CaMキナーゼIV / 記憶 / 遺伝子発現 / シナプス伝達長期増強 / カルモデュリンキナーゼII / 転写調節 / 脳由来神経栄養因子(BDNF) / NMDA受容体 / グルタミン酸受容体 / hippocampus / 核移行シグナル / cDNA / 核内移行シグナル / プロテインホスファターゼ2A / カルシウムイオン / gene expression / NE-dlg / scaffold protein / NG108-15 cells / calmodulin-dependent protein kinase II / Ca^<2+> / NMDA receptor / CA1 / CaM kinase IV / MAP kinase / memory / learning / Nuclear localization signal / Calcium ion / 自己燐酸化反応 / CaMキナーゼ / 細胞モデル / 抗体 / バナジウム化合物 / 認知機能 / アルツハイマー病 / CaMキナーゼキナーゼ / 燐酸化特異抗体 / MIN6細胞 / シナプシンI / インスリン分泌反応 / アストロサイト / PSD-95 / SAP102 / クラスタリング分子 / CREB / 神経細胞死 / 阻害薬 / CAI領域 / 培養細胞 / 初代培養神経細胞 / vanadium compound / calpain / brain edema / nitric oxide / calmodulin antagonist / myocardial ischemia / brain ischemia / ニトロチロシン / Forkhead transcription factor / Fasリガンド / プロテインキナーゼ / 虚血耐性 / 脳梗塞 / 遅発性神経細胞死 / Akt / バナジウム / 中大脳動脈閉塞モデル / 脳保護薬 / カルパイン / 一酸化窒素 / 脳浮腫 / カルモデュリン阻害剤 / 心筋虚血 / 脳虚血 / cell model / brain-derived neurotrophic factor / NG108--15 cell / nuclear localization signal / dopamine D2 receptor / Ca^<2+> signaling / CaM kivases / CaMキナーゼIIサブタイプ / Ca^<2+>シグナル / 異所性遺伝子発現 / ドーパミンD2受容体 / 蛋白質リン酸化反応 / 後シナプス神経細胞 / MIN6 cells / Brain-derived neurotrophic factor / Synapsin I / Insulin secretion / Gene expression / Astrocyte / 小胞体 / ゴルジ体 / 可変領域 / インスリン分泌細胞 / SAPI02 / postsynaptic density / excitatory synapse / カリウムチャネル / PDZドメイン / シナプス / scafold protein / 興奮性シナプス / ドーパミン受容体 / Temporal lobe epilepsy / Naurite outgrowth / Hippocampus / Cytoskeletal proteins / Brain-derived neurotrophic factor (BDNF) / MARCKS / Cキナーゼ / 側頭葉てんかん / 神経突起形成 / 細胞骨格蛋白質 / カルモデュリンキナーザII / protein phosphatase 2A / synaptic plasticity / autophosphorylation / スパイン / LTP / Cellular functions / Calcineurin / Cultured cell / Signal transduction / Receptor / 脳由来神経成長因子 / δサブユニット / 細胞内応答 / 受容体刺激 / 細胞機能 / 細胞内情報伝達 / 細胞内Ca^<2+> / 受容体 / protein dephosphorylation / protein phosphatase / 蛋白質燐酸化反応 / 後シナプス細胞 / 蛋白質脱燐酸化反応 / Overexpression / Cloned stable cell / Gene insertion / Cellular model / ジブチリルcAMP / 神経突起伸展反応 / PC12細胞 / MAP2 / 発現細胞 / サブユニットアイソフォーム / 強制発現 / 安定クローン細胞 / 遺伝子強制導入 / ABCトランスポーター / アミロイドーシス / 脂質異常症 / コレステロール代謝 / ＨＤＬ / 糖鎖 / 脂質膜 / アミロイド / コンフォメーション / HDL / アポリポタンパク質 / 恐怖行動 / 帯状回皮質 / 多価不飽和脂肪酸 / ノックアウトマウス / アセチルコリン / カタレプシー / 線条体 / ドパミンD2受容体 / 心臓型脂肪酸結合蛋白質 / 内皮型-酸化窒素合成酵素 / 神経新生 / 嗅球摘出マウス / 脳血管保護作用 / 内皮型一酸化窒素合成酵素 / 脳血管障害 / 薬物治療学 / D2受容体 / 覚醒剤中毒 / NF-κB / ドパミン受容体 / 統合失調症 / 逆耐性現象 / メタンフェタミン / 活性化反応 / グルタミン酸 / 海馬初代培養神経細胞 / 海馬CA1 / AMPA受容体 / long-term potemtiation / プロモーター解析 / 転写因子 / 神経活動依存性 / 長期記憶 / 小脳顆粒細胞 / BDNF / CamキナーゼII / 小脳 / 顆粒細胞 / 遺伝子組換え実験 / 遺伝子組替え実験 / チロシンキナーゼ / Pyk2 / CAKβ Less

Physicochemical mechanism on formation and metabolism of HDL particles by apolipoproteins
- Principal Investigator
  
  Saito Hiroyuki
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kyoto Pharmaceutical University
  The University of Tokushima
Analysis of molecular mechanisms related to the vulnerability and anti-depression in neurons.Principal Investigator
- Principal Investigator
  
  KASAHARA Jiro
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Experimental pathology
- Research Institution
  The University of Tokushima
  Tohoku University
脂肪酸結合蛋白質によるドパミン受容体調節と神経機能における役割
- Principal Investigator
  
  福永浩司
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Biological pharmacy
- Research Institution
  Tohoku University
Development of novel neuroprotective drugs targeting for neurovascular unit therapy.
- Principal Investigator
  
  FUKUNAGA Kohji
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied pharmacology
- Research Institution
  Tohoku University
Basic study in mice to establish a novel screening system of antidepressants.Principal Investigator
- Principal Investigator
  
  KASAHARA Jiro
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Experimental pathology
- Research Institution
  Tohoku University
中枢興奮薬の逆耐性現象における神経可塑性を標的とした創薬研究
- Principal Investigator
  
  福永浩司
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Tohoku University
中枢神経細胞におけるCaM kinase kinaseの活性動態と機能Principal Investigator
- Principal Investigator
  
  笠原二郎
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Tohoku University
Drug development by signal transduction therapy in the ischemic brain injury.
- Principal Investigator
  
  FUKUNAGA Kohji
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  Tohoku University
カルモデュリン依存性プロテインキナーゼIIの神経細胞内局在とシナプス機能の調節
- Principal Investigator
  
  山本秀幸
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Kumamoto University
脳海馬長期増強誘導,維持の分子機構に関する研究
- Principal Investigator
  
  宮本英七
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  Kumamoto University
遺伝子発現の脳可塑性形成への必須性に関する研究
- Principal Investigator
  
  宮本英七
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Kumamoto University
Establishment of cell models on transfection of functional protein and the study on brain signal transduction
- Principal Investigator
  
  MIYAMOTO Eishichi
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  Kumamoto University
カルモデュリン依存性蛋白質燐酸化反応による脳由来神経栄養因子産生の調節機構
- Principal Investigator
  
  山本秀幸
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Kumamoto University
海馬シナプス可塑性におけるカルモデュリンキナーゼIIの役割
- Principal Investigator
  
  福永浩司
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  Kumamoto University
カルモデュリン依存性キナーゼIVの活性制御機構と神経機能との関わりPrincipal Investigator
- Principal Investigator
  
  笠原二郎
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Kumamoto University
Neuropharmacological studies of clustering molecules expressing in the excitatory synapses
- Principal Investigator
  
  FUKUNAGA Kohji
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  Kumamoto University
Functional and structural diversity of variable domain of Ca^<2+>/calmodulin-dependent protein kinase II
- Principal Investigator
  
  YAMAMOTO Hideyuki
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Kumamoto University
Molecular and cytobiological study on regulation of synapse
- Principal Investigator
  
  MIYAMOTO Eishichi
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Kumamoto University
海馬シナプス伝達長期増強・長期抑圧の誘発と維持におけるプロテインキナーゼの役割
- Principal Investigator
  
  福永浩司
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Kumamoto University
カルモデュリン依存性蛋白質燐酸化反応による神経栄養因子産生の調節に関する研究
- Principal Investigator
  
  山本秀幸
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Kumamoto University
神経活動依存性遺伝子発現活性化機構の研究
- Principal Investigator
  
  宮本英七
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Kumamoto University
海馬シナプス伝達長期増強の誘発と維持におけるプロテインキナーゼの役割
- Principal Investigator
  
  福永浩司
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kumamoto University
蛋白質燐酸化反応と障害神経細胞での軸索とシナプス再形成に関する分子生物学的研究
- Principal Investigator
  
  山本秀幸
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kumamoto University
Molecular cytobiological study on hippocampal LTP and LTD
- Principal Investigator
  
  MIYAMOTO Eishichi
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Kumamoto University
Molecular cytobiological study on CaィイD12+ィエD1 signaling in the cells with cultured cells
- Principal Investigator
  
  MIYAMOTO Eishichi
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Kumamoto University
Working mechanism of Ca^<2+>/calmodulin-dependent protein kinase II in synaptic plasticity
- Principal Investigator
  
  FUKUNAGA Kohji
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Kumamoto University
Molecular and cellular biological study about the abnormal neurite outgrowth and protein phosphorylation in temporal lobe epilepsy
- Principal Investigator
  
  YAMAMOTO Hideyuki
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Kumamoto University
神経伝達物質による細胞増殖,分化機構の研究
- Principal Investigator
  
  MIYAMOTO Eishichi
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Kumamoto University
Establishment of stable cells by induction of cDNAs of functional proteins and preparation of models for evaluation of drug efficacy for creation of new drugs
- Principal Investigator
  
  MIYAMOTO Eishichi
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  General pharmacology
- Research Institution
  Kumamoto University

All 2011 2010 2009 2008 2007 2005 2004 2002

All Journal Article Presentation

[Journal Article] Therapeutic effect of a novel anti-parkinsonian agent zonisamide against MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropy ridine)neurotoxicity in mice.2010
- Author(s)
  Yokoyama H, Yano R, Kuroiwa H, Tsukada T, Uchida H, Kato H, Kasahara J, Araki T.
- Journal Title
  
  Metabolic Brain Disease 25(2)
  
  Pages: 135-143
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790376
[Journal Article] Role of inducible or neuronal nitric oxide synthase in neurogenesis of the dentate gyrus in aged mice.2010
- Author(s)
  Adachi M, Abe M, Sasaki T, Kato H, Kasahara J, Araki T.
- Journal Title
  
  Metabolic Brain Disease 25(4)
  
  Pages: 419-424
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790376
[Journal Article] Damage to neurons and oligodendrocytes in the hippocampal CA1 sector after transient focal ischemia in rats.2010
- Author(s)
  Uchida H, Fujita Y, Matsueda M, Umeda M, Matsuda S, Kato H, Kasahara J, Araki T.
- Journal Title
  
  Cellular and Molecular Neurobiology 30(7)
  
  Pages: 1125-1134
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790376
[Journal Article] Comprehensive behavioral analysis of calcium/calmodulin-dependent protein kinase IV knockout mice.2010
- Author(s)
  K.Takao, K.Tanda, K.Nakamura, J.Kasahara, K.Nakao, M.Katsuki, K.Nakanishi, N.Yamasaki, K.Toyama, M.Adachi, M.Umeda, T.Araki, K.Fukunaga, H.Kondo, H.Sakagami, T.Miyakawa
- Journal Title
  
  PLoS One 5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390150
[Journal Article] Comprehensive behavioral analysis of calcium/calmodulin-dependent protein kinase IV knockout mice.2010
- Author(s)
  K.Takao, K.Tanda, K.Nakamura, J.Kasahara, K.Nakao, M.Katsuki, K.Nakanishi, N.Yamasaki, K.Toyama, M.Adachi, M.Umeda, T.Araki, K.Fukunaga, H.Kondo, H.Sakagami, T.Miyakawa.
- Journal Title
  
  PLoS One 5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20659008
[Journal Article] Alterations of interneurons in the striatum and frontal cortex of mice during postnatal development.2010
- Author(s)
  Eto R, Abe M, Kimoto H, Imaoka E, Kato H, Kasahara J, Araki T.
- Journal Title
  
  International Journal of Developmental Neuroscience 28(5)
  
  Pages: 359-370
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790376
[Journal Article] Comprehensive behavioral analysis of calcium/calmodulin-dependent protein kinase IV knockout mice.2010
- Author(s)
  Takao K, Tanda K, Nakamura K, Kasahara J, Nakao K, Katsuki M, Nakanishi N, Toyama K, Adachi M, Umeda M, Araki T, Fukunaga K, Kondo H, Sakagami H, Miyakawa T
- Journal Title
  
  PLoS One 5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790376
[Journal Article] Postnatal development of neurons, interneurons and glial cells in the substantia nigra of mice.2010
- Author(s)
  Abe M, Kimoto H, Eto R, Sasaki T, Kato H, Kasahara J, Araki T.
- Journal Title
  
  Cellular and Molecular Neurobiolgy 30(6)
  
  Pages: 917-928
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790376
[Journal Article] Ca2+/Calmodulin-dependent Protein Kinase IV-mediated LIM-kinase Activation Is Critical for Calcium Signal-induced Neurite Outgrowth2009
- Author(s)
  M.Takemura, T.Mishima, Y.Wang, J.Kasahara, K.Fukunaga, K.Ohashi, K Mizuno
- Journal Title
  
  J.Biol.Chem. 284
  
  Pages: 28554-28562
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390150
[Journal Article] Ca2+/Calmodulin-dependent Protein Kinase IV-mediated LIM-kinase Activation Is Critical for Calcium Signal-induced Neurite Outgrowth.2009
- Author(s)
  M.Takemura, T.Mishima, Y.Wang, J.Kasahara, K.Fukunaga, K.Ohashi, K Mizuno
- Journal Title
  
  J.Biol.Chem. 284
  
  Pages: 28554-28562
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20659008
[Journal Article] Ca2+/calmodulin-dependent protein kinase IV-mediated LIM kinase activation is critical for calcium signal-induced neurite outgrowth.2009
- Author(s)
  Takemura M, Mishima T, Wang Y, Kasahara J, Fukunaga K, Ohashi K, Mizuno K.
- Journal Title
  
  The Journal of Biological Chemistry 284
  
  Pages: 28554-28562
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790376
[Journal Article] Ca/calmodulin-dependent protein kinase IV-mediated LIM kinase activation is critical for calcium signal-induced neurite outgrowth2009
- Author(s)
  Takemura M, Mishima T, Wang Y, Kasahara J, Fukunaga K, Ohashi K, Mizuno K
- Journal Title
  
  The Journal of Biological Chemistry 284
  
  Pages: 28554-28562
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790376
[Journal Article] Cardioprotective effect of vanadyl sulfate on ischemia/reperfusion-induced injury in rat heart in vivo is mediated by activation of protein kinase B and induction of FLICE-inhibitory protein.2008
- Author(s)
  Bhuiyan MS, Takada Y, Shioda N, Moriguchi S, Kasahara J, Fukunaga K.
- Journal Title
  
  Cardiovascular Therapeutics 26
  
  Pages: 10-23
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790280
[Journal Article] Cardioprotective effect of vanadyl sulfate on ischemia/reperfusion-induced injury in rat heart in vivo is mediated by activation of protein kinase B and induction of FLICE-inhibitory protein2008
- Author(s)
  Bhuiyan MS, Takada Y, Shioda N, Moriguchi S, Kasahara J. Fukunaga K.
- Journal Title
  
  Cardiovasc Ther 26
  
  Pages: 10-23
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20659008
[Journal Article] Cardioprotective effect of vanadyl sulfate on ischemia / reperfusion-induced injury in rat heart in vivo is mediated by activation of protein kinase B and induction of FLICE-inhibitory protein2008
- Author(s)
  Bhuiyan MS, Takada Y, Shioda N, Moriguchi S, Kasahara J. Fukunaga K.
- Journal Title
  
  Cardidvasc Ther. 26
  
  Pages: 10-23
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390150
[Journal Article] Cardioprotective effect of vanadyl sulfate on ischemia/reperfusion-induced injury in rat heart in vivo is mediated by activation of protein kinase B and induction of FLICE-inhibitory protein2008
- Author(s)
  Bhuiyan MS, Takada Y, Shioda N, Moriguchi S, Kasahara J, Fukunaga K
- Journal Title
  
  Cardiovascular Therapeutics 26
  
  Pages: 10-23
- Data Source
  KAKENHI-PROJECT-19790280
[Journal Article] Cardioprotective effect of vanadyl sulfate on ischemia/reperfusion-induced injury in rat heart in vivo is mediated by activation of protein kinase B and induction of FLICE-inhibitory protein2008
- Author(s)
  MS. Bhuiyan, Y. Takada, N. Shioda, S. Moriguchi, J. Kasahara, K. Fukunaga
- Journal Title
  
  Cardiovasc.Ther. 26
  
  Pages: 10-23
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390150
[Journal Article] Cytoprotective effect of bis(1-oxy-2-pyridinethiolato)oxovanadiun(IV) on myocardial ischemia/reperfusion injury elicits inhibition of Fas ligand and Bim expression and elevation of FLIP expression2008
- Author(s)
  MS. Bhuiyan, M. Shibuya, N. Shioda, S. Moriguchi, J. Kasahara, Y. Iwabuchi, K. Fukunaga
- Journal Title
  
  Eur.J.Pharmacol. 571
  
  Pages: 180-188
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390150
[Journal Article] Imbalance between CaM kinase II and calcineurin activities impairs caffeine-induced calcium release in hypertrophic cardiomyocytes.2007
- Author(s)
  Y-M. Lu, N. Shioda, F. Han, S. Moriguchi, J. Kasahara, Y. Shirasaki, Z. H. Qin, K. Fukunaga.
- Journal Title
  
  Biochem Pharmacol. 74
  
  Pages: 1727-1737
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390150
[Journal Article] Reduced CREB phosphorylation after chronic lithium treatment is associated with down-regulation of CaM kinase IV in rat hippocampus.2007
- Author(s)
  Tardito D, Tiraboschi E, Kasahara J., et. al.
- Journal Title
  
  International Journal of Neuropsychopharmacology. 10(4)
  
  Pages: 491-496
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790280
[Journal Article] Reduced CREB phosphorylation after chronic lithium treatment is associated with down-regulation of CaM kinase IV in rat hippocampus2007
- Author(s)
  Tardito D, Tiraboschi E, Kasahara J. et al.
- Journal Title
  
  International Journal of Neuropsychopharmacology 10(4)
  
  Pages: 491-496
- Data Source
  KAKENHI-PROJECT-19790280
[Journal Article] Cytoprotective effect of bis(1-oxy-2-pyridinethiolato)oxovanadiun(IV)on myocardial ischemia/reperfusion injury elicits inhibition of Fas li gand end Bim expression and elevation of FLIP expression.2007
- Author(s)
  M. S. Bhuiyan, M. Shibuya, N. Shioda, S. Moriguchi, J. Kasahara, Y. Iwabuchi and K. Fukunaga
- Journal Title
  
  European Journal of Pharmacology 571
  
  Pages: 180-188
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390150
[Journal Article] Imbalance between CaM kinase II and calcineurin activities impairs caffeine-induced calcium release in hypertrophic cardiomyocytes2007
- Author(s)
  Lu YM., Shioda N., Han F., Moriguchi S., Kasahara J., Shirasaki Y., Win ZH. and Fukunaga, K
- Journal Title
  
  Biochemical Pharmacology 74(12)
  
  Pages: 1727-1737
- Data Source
  KAKENHI-PROJECT-19790280
[Journal Article] Cytoprotective effect of bis(1-oxy-2-pyridinethiolato)oxovanadiun(IV) on myocardial ischemia/reperfusion injury elicits inhibition of Fas ligand and Bim expression and elevation of FLIP expression2007
- Author(s)
  Bhuiyan MS., Shibuya M., Shioda N., Moriguchi S., Kasahara J., Iwabuchi Y. and Fukunaga K
- Journal Title
  
  European. Journal of Pharmacology 571(203)
  
  Pages: 180-188
- Data Source
  KAKENHI-PROJECT-19790280
[Journal Article] Cytoprotective effect of 3-[2-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole dihydrochloride 3.5 hydrate (DY-9760e) on ischemia/reperfusion-induced injury in the rat heart involves inhibition of fodrin breakdown and protein tyrosine nitration.2005
- Author(s)
  M.Hashimoto, Y.Takada, Y.Takeuchi, J.Kasahara, H.Hisa, Y.Shirasaki, K.Fukunaga
- Journal Title
  
  J.Pharmacol.Sci. (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370035
[Journal Article] Effect of lithium on the circadian rhythms of locomotor activity and GSK-3 protein expression in the mouse suprachiasmatic nuclei.2004
- Author(s)
  Iwahana, E., Akiyama, M., Miyakawa, K., Uchida, A., Kasahara, J., Fukunaga, K., Hamada, T., Shibata, S.
- Journal Title
  
  European Journal of Neuroscience 19
  
  Pages: 2281-2287
- Data Source
  KAKENHI-PROJECT-15700283
[Journal Article] Entrapment of migrating hippocampal neural cells in three-dimensional peptide nanofiber scaffold.2004
- Author(s)
  Semino, CE., Kasahara, J., Hayashi, Y., Zhang, S.
- Journal Title
  
  Tissue Engineering 10
  
  Pages: 643-655
- Data Source
  KAKENHI-PROJECT-15700283
[Journal Article] Expression and phosphorylation of δ-CaM Kinase II in cultured Alzheimer skin fibroblasts.2004
- Author(s)
  Cavazzin, C., Bonvicini, C., Nocera, A., Racchi, M., Kasahara, J., Tardito, D., Gennarelli, M., Govoni, S., Racagni, G., Popoli, M.
- Journal Title
  
  Neurobiology of Aging 25(9)
  
  Pages: 1187-1196
- Data Source
  KAKENHI-PROJECT-15700283
[Journal Article] Cytoprotective effect of sodium orthovanadate on ischemia/reperfusion-induced injury in the rat heart involves Akt activation and inhibition of fodrin breakdown and apoptosis.2004
- Author(s)
  Takada, Y., Hashimoto, M., Kasahara, J., Aihara, K., Fukunaga, K.
- Journal Title
  
  Journal of Pharmacological and Experimental Therapeutics 311(3)
  
  Pages: 1249-1255
- Data Source
  KAKENHI-PROJECT-15700283
[Journal Article] Effects of lithium on the circadian rhythms of locomotor activity and GSK-3 protein expression in the mouse suprachiasmatic nuclei.2004
- Author(s)
  E.Iwahana, M.Akiyama, K.Miyakawa, A.Uchida, J.Kasahara, K.Fukunaga, T.Hamada, S.Shibata
- Journal Title
  
  Eur.J.Neurosci. 19
  
  Pages: 2281-2287
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370035
[Journal Article] Selective phosphorylation of nuclear CREB by fluoxetine is linked to activation of CaM kinase IV and MAP kinase cascades.2004
- Author(s)
  Tiraboschi, E., Tardito, D., Kasahara, J., Moraschi, S., Pruneri, P., Gennarelli, M., Racagni, G., Popoli, M.
- Journal Title
  
  Neuropsychopharmacology 29
  
  Pages: 1831-1840
- Data Source
  KAKENHI-PROJECT-15700283
[Journal Article] Cytoprotective effect of sodium orthovanadate on ischemia/reperfusion-induced injury in the rat heart involves Akt activation and inhibition of fodrin breakdown and apoptosis.2004
- Author(s)
  Y.Takada, M.Hashimoto, J.Kasahara, K.Aihara, K.Fukunaga
- Journal Title
  
  J.Pharmacol Exp.Therap. 131
  
  Pages: 1249-1255
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370035
[Journal Article] Activation of Ca^<2+>/calmodulin-dependent protein kinase I in cultured rat hippocampal neurons.2002
- Author(s)
  A.Uezu, K.Fukunaga, J.Kasahara, E.Miyamoto
- Journal Title
  
  J.Neurochem. 82
  
  Pages: 585-593
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370035
[Presentation] 荒木勉MPTPモデルマウスにおけるパーキンソン病様症状に対するゾニサミドの治療効果2011
- Author(s)
  笠原二郎、横山宏典、矢野遼平、加藤宏之
- Organizer
  第84回日本薬理学会年会
- Place of Presentation
  誌上開催
- Year and Date
  2011-03-24
- Data Source
  KAKENHI-PROJECT-21790376
[Presentation] MPTPモデルマウスにおけるパーキンソン病様症状に対するゾニサミドの治療効果2011
- Author(s)
  笠原二朗, ほか
- Organizer
  第84回日本薬理学会年会
- Place of Presentation
  (誌上開催)
- Year and Date
  2011-03-24
- Data Source
  KAKENHI-PROJECT-21790376
[Presentation] マウス大脳皮質初代培養神経細胞におけるセロトニンによるCREBリン酸化反応はCaMKIVとMAPK(ERK)を介する.2010
- Author(s)
  笠原二郎、大村幸司、福永浩司
- Organizer
  第83回日本薬理学会年会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-19390150
[Presentation] セロトニンによるCaMKIVとERKを介したCREBリン酸化反応2010
- Author(s)
  笠原二朗, ほか
- Organizer
  第33回神経科学大会
- Place of Presentation
  神戸市
- Year and Date
  2010-09-02
- Data Source
  KAKENHI-PROJECT-21790376
[Presentation] セロトニンによるCaMKIV とERK を介したCREBリン酸化反応2010
- Author(s)
  笠原二郎、安達みなみ、大村幸司、福永浩司、荒木勉
- Organizer
  第33回神経科学大会
- Place of Presentation
  神戸
- Year and Date
  2010-09-02
- Data Source
  KAKENHI-PROJECT-21790376
[Presentation] マウス大脳皮質初代培養神経細胞におけるセロトニンによるCREBリン酸化反応はCaMKIV とMAPK (ERK)を介する2010
- Author(s)
  笠原二郎、大村幸司、安達みなみ、福永浩司、荒木勉
- Organizer
  第83回日本薬理学会年会
- Place of Presentation
  大阪
- Year and Date
  2010-03-17
- Data Source
  KAKENHI-PROJECT-21790376
[Presentation] マウス大脳皮質初代培養神経細胞におけるセロトニンによるCREBリン酸化反応はCaMKIVとMAPK(ERK)を介する2010
- Author(s)
  笠原二郎, 大村幸司, 福永浩司
- Organizer
  第83回日本薬理学会年会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-19390150
[Presentation] Serotonin (5-HT)-induced CREB phosphorylation in the cortical neurons of mice Annual Meeting of SfN2010
- Author(s)
  Kasahara J, Adachi M, Oomura K, Fukunaga K, Araki T.
- Place of Presentation
  San Diego, USA
- Year and Date
  2010-11-17
- Data Source
  KAKENHI-PROJECT-21790376
[Presentation] マウス大脳皮質初代培養神経細胞におけるセロトニンによるCREBリン酸化反応はCaMKIVとMAPK (ERK)を介する.2010
- Author(s)
  笠原二郎、大村幸司、福永浩司
- Organizer
  第83回日本薬理学会年会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20659008
[Presentation] マウス大脳皮質初代培養神経細胞におけるセロトニンによるCREBリン酸化反応はCaMKIVとMAPK(ERK)を介する2010
- Author(s)
  笠原二郎、大村幸司、安達みなみ、福永浩司、荒木勉
- Organizer
  第83回日本薬理学会年会
- Place of Presentation
  大阪
- Year and Date
  2010-03-17
- Data Source
  KAKENHI-PROJECT-21790376
[Presentation] Serotonin (5-HT)-induced CREB phosphorylation in the cortical neurons of mice.2010
- Author(s)
  Jiro Kasahara, et al.
- Organizer
  Annual Meeting of SfN 2010
- Place of Presentation
  San Diego, USA
- Year and Date
  2010-11-17
- Data Source
  KAKENHI-PROJECT-21790376
[Presentation] マウス大脳皮質初代培養ニューロンにおけるセロトニンによるCREBリン酸化反応2009
- Author(s)
  笠原二郎、大村幸司、福永浩司
- Organizer
  第32回神経科学大会
- Place of Presentation
  名古屋
- Year and Date
  2009-09-16
- Data Source
  KAKENHI-PROJECT-21790376
[Presentation] マウス大脳皮質初代培養ニューロンにおけるセロトニンによるCREBリン酸化反応.2009
- Author(s)
  笠原二郎、大村幸司、福永浩司
- Organizer
  第32回日本神経科学大会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-19390150
[Presentation] マウス大脳皮質初代培養ニューロンにおけるセロトニンによるCREBリン酸化反応2009
- Author(s)
  笠原二郎、大村幸司、福永浩司
- Organizer
  第32回日本神経科学大会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-20659008
[Presentation] バナジウム化合物とメラトニンによるドパミン神経障害の保護効果2008
- Author(s)
  笠原二郎、長井智史、澁谷正俊、荒木令江、岩渕好治、福永浩司
- Organizer
  第31回神経科学大会
- Place of Presentation
  東京
- Year and Date
  2008-07-11
- Data Source
  KAKENHI-PROJECT-19790280
[Presentation] マウス脳における抗うつ薬慢性投与によるカルモジュリンキナーゼIVの活性化とCREBリン酸化反応2008
- Author(s)
  笠原二郎、阪上洋行、福永浩司
- Organizer
  第81回日本薬理学会年会
- Place of Presentation
  横浜市
- Year and Date
  2008-03-17
- Data Source
  KAKENHI-PROJECT-19790280
[Presentation] マウス脳における抗うつ薬慢性投与によるカルモジュリンキナーゼIVの活性化とCREBリン酸化反応2008
- Author(s)
  笠原二郎、阪上洋行、福永浩司
- Organizer
  第81回日本薬理学会年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-17
- Data Source
  KAKENHI-PROJECT-19790280
[Presentation] バナジウム化合物とメラトニンによるドパミン神経障害の保護効果Neuroprotective effect of a vanadium compound and melatonin in MPTP-induced dopaminergic defects in mice2008
- Author(s)
  Jiro Kasahara, Tomofumi Nagai, Masatoshi Shibuya, Yoshiharu Iwabuchi, Norie Araki and Kohji Fukunaga
- Organizer
  神経科学学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20659008
[Presentation] バナジウム化合物とメラトニンによるドパミン神経障害の保護効果Neuroprotective effect of a vanadium compound and melatonin in MPIP-induced dopaminergic defects in mice2008
- Author(s)
  Jiro Kasahara, Tomofumi Nagai, Masatoshi Shibuya, Yoshiharu Iwabuchi, Norie Araki and Kohji Fukunaga
- Organizer
  神経科学学会
- Place of Presentation
  東京
- Year and Date
  2008-07-11
- Data Source
  KAKENHI-PROJECT-19390150
[Presentation] マウス脳における抗うつ薬慢性投与によるカルモジュリンキナーゼIVの活性化とCREBリン酸化反応2008
- Author(s)
  笠原二郎、阪上洋行、福永浩司(口演)
- Organizer
  第81回日本薬理学会年会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-19390150
[Presentation] マウス脳におけるCaMKIV活性は抗うつ薬の効果発現に必要である2007
- Author(s)
  笠原二郎、阪上洋行、近藤尚武、福永浩司(口演)
- Organizer
  日本生化学会東北支部会
- Place of Presentation
  東北大学医学部艮陵会館
- Year and Date
  2007-05-12
- Data Source
  KAKENHI-PROJECT-19390150
[Presentation] Requirement of calcium/calmodulin-dependent protein kinase IV(CaMKIV)-activity for the effects of antidepressants in mouse brain.2007
- Author(s)
  Kasahara J., Fukunaga K. and Sakagami H.
- Organizer
  Society for Neuroscience 2007
- Place of Presentation
  アメリカ合衆国・サンディエゴ
- Year and Date
  2007-11-07
- Data Source
  KAKENHI-PROJECT-19790280
[Presentation] マウス脳におけるCaMKIV活性は抗うつ薬の効果発現に必要である2007
- Author(s)
  笠原二郎、阪上洋行、近藤尚武、福永浩司
- Organizer
  第73回日本生化学会東北支部会例会
- Place of Presentation
  仙台市
- Year and Date
  2007-05-12
- Data Source
  KAKENHI-PROJECT-19790280
[Presentation] マウス脳におけるCaMKIV活性は抗うつ薬の効果発現に必要である2007
- Author(s)
  笠原二郎、阪上洋行、近藤尚武、福永浩司
- Organizer
  第73回日本生化学会東北支部会例会
- Place of Presentation
  仙台
- Year and Date
  2007-05-12
- Data Source
  KAKENHI-PROJECT-19790280
[Presentation] Requirement of calcium/calmodulin-dependent protein kinase IV (CaMKIV)-activity for the effects of antidepressants2007
- Author(s)
  Jiro Kasahara, Kohji Fukunaga and Hiroyuki Sakagami (poster)
- Organizer
  37th. Society for Neuroscience; Annual Meeting
- Place of Presentation
  San Diego
- Data Source
  KAKENHI-PROJECT-19390150
[Presentation] Requirement of calcium/calmodulin-dependent protein kinase IV (CaMKIV)-activity for the effects of antidepressants in mouse brain2007
- Author(s)
  Kasahara J., Fukunaga K. and Sakagami H
- Organizer
  Society for Neuroscience 2007
- Place of Presentation
  アメリカ合衆国・サンディエゴ
- Year and Date
  2007-11-07
- Data Source
  KAKENHI-PROJECT-19790280

1. FUKUNAGA Kohji (90136721)

# of Collaborated Projects: 21 results

# of Collaborated Products: 24 results
2. MIYAMOTO Eishichi (50109659)

# of Collaborated Projects: 20 results

# of Collaborated Products: 0 results
3. YAMAMOTO Hideyuki (60191433)

# of Collaborated Projects: 20 results

# of Collaborated Products: 0 results
4. TAKEUCHI Yusuke (90336214)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
5. MORIOKA Motohiro (20295140)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. SHIODA Norifumi (00374950)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
7. IWABUCHI Yushiharu (20211766)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
8. MORIGUCHI Shigeki (70374949)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
9. Saito Hiroyuki (60300919)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. AKAJI Kenichi (60142296)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. OTAKA Akira (20201973)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. OKAMURA Emiko (00160705)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. KOBAYASHI Norihiro (90205477)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. KITAGAWA Shuji (00108911)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. MICHIKAWA Makoto (40270912)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. YANO Shigetoshi (60332871)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 長尾耕治郎 (40587325)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 比佐博彰 (60192712)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
19. MULLER Dominique

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. SODERLING Th

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. SODERLING Thomas R

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Kasahara Jiro 笠原 二郎

笠原 二郎 カサハラ ジロウ

KASAHARA Jiro 笠原 二郎

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Analysis of molecular mechanisms related to the vulnerability and anti-depression in neurons.Principal Investigator

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Basic study in mice to establish a novel screening system of antidepressants.Principal Investigator

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中枢神経細胞におけるCaM kinase kinaseの活性動態と機能Principal Investigator

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カルモデュリン依存性キナーゼIVの活性制御機構と神経機能との関わりPrincipal Investigator

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Kasahara Jiro 笠原二郎

笠原二郎カサハラジロウ

KASAHARA Jiro 笠原二郎