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Ohkuchi Akihide  大口 昭英

… Alternative Names

OHKUCHI Akihide  大口 昭英

OKUCHI Akihide  大口 昭英

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Researcher Number 10306136
Other IDs
  • ORCIDhttps://orcid.org/0000-0002-8861-1572
Affiliation (Current) 2025: 自治医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help 2015 – 2024: 自治医科大学, 医学部, 教授
2012 – 2015: 自治医科大学, 医学部, 准教授
2007: Jichi Medical University, Department of Obstetrics and Gynecology, Associate Professor
2006: 自治医科大学, 医学部, 講師
2003 – 2004: 自治医科大学, 医学部, 講師
Review Section/Research Field
Principal Investigator
Obstetrics and gynecology / Basic Section 56040:Obstetrics and gynecology-related
Except Principal Investigator
Obstetrics and gynecology / Basic Section 56040:Obstetrics and gynecology-related / Basic Section 52050:Embryonic medicine and pediatrics-related
Keywords
Principal Investigator
妊娠高血圧腎症 / 発症予知 / prediction / soluble endoglin / placental growth factor / sFlt-1 / 臨床 / 胎盤蛋白質 / バイオマーカー / 妊娠初期 … More / multivariable analysis / blood pressure / preterm preeclampsia / galectin 1 / HSD17B1 / preeclampsia / prehvnertension / second trimester / soluble fins-like tvrosine kinase 1 / placental eowth factor / preeclamnsia / uterine artery flow velocity waveform / 血圧正常高値 / 高血圧腎症 / b4:z3z / notch depth index / PIGF / 高血圧前症 / 妊娠中期 / soluble fms-like tyrosine kinase 1 / 子宮動脈血流速度波形 / PlGF / 妊娠高血圧症候群 / sFlt-1/PlGF比 … More
Except Principal Investigator
胎盤 / 妊娠高血圧腎症 / 妊娠高血圧症候群 / 妊娠 / 産科学 / エクソソーム / ELISA / ELISA法 / 予知 / 超遠心法 / 細胞外小胞 / 早産 / microRNA / マイクロRNA / 細胞外ナノ粒子 / CD9 / フローサイトメトリー法 / 胎盤由来エクソソーム / PLAP / 腎疾患 / 心血管系疾患 / 早産低出生体重児 / メチル化 / DROSHA / ウイルス感染 / 発症予測 / 精製方法 / 正常妊婦 / カラム法 / 血漿 / 発症予知 / 競合内在性RNA / ncRNA / ceRNA / 絨毛膜外栄養膜 / WNT / バイオマーカー / 絨毛外栄養膜 / phagocytosis / leukocyte / preterm delivery / enzymehistochemistry / macrophage / placenta / chorion / amnion / 組織化学 / 貪食 / 白血球 / 電顕酵素組織化学 / マクロファージ / 卵膜 / 羊膜 / 炎症 / インフラマソーム / micro RNA Less
  • Research Projects

    (14 results)
  • Research Products

    (162 results)
  • Co-Researchers

    (28 People)
  •  胎盤由来細胞間輸送体の新パラダイムによる妊娠高血圧腎症・早産の病態解明と発症予知

    • Principal Investigator
      瀧澤 俊広
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56040:Obstetrics and gynecology-related
    • Research Institution
      Nippon Medical School
  •  妊娠初期妊婦レジストリ事業の発足並びに早産期発症妊娠高血圧腎症予測モデルの開発Principal Investigator

    • Principal Investigator
      大口 昭英
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56040:Obstetrics and gynecology-related
    • Research Institution
      Jichi Medical University
  •  胎盤由来エクソソームによる妊娠高血圧腎症の予知法に関する研究

    • Principal Investigator
      鈴木 寛正
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56040:Obstetrics and gynecology-related
    • Research Institution
      Jichi Medical University
  •  Methylation of genes related to cardiovascular and chronic kidney diseases in preterm low birth weight infants born to mothers with hypertensive disorders of pregnancy

    • Principal Investigator
      河野 由美
    • Project Period (FY)
      2021 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Jichi Medical University
  •  Elucidation of the novel function of trophoblast DROSHA as a novel therapeutic strategy for preventing congenital viral infection

    • Principal Investigator
      Takizawa Toshihiro
    • Project Period (FY)
      2020 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56040:Obstetrics and gynecology-related
    • Research Institution
      Nippon Medical School
  •  Research on prediction of preeclampsia by extracellular vesicles in maternal plasma

    • Principal Investigator
      Suzuki Hirotada
    • Project Period (FY)
      2019 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56040:Obstetrics and gynecology-related
    • Research Institution
      Jichi Medical University
  •  Prediction of preeclampsia using circulationg levels of Galectin-1 and HSD17B1 in the first trimesterPrincipal Investigator

    • Principal Investigator
      Ohkuchi Akihide
    • Project Period (FY)
      2017 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      Jichi Medical University
  •  Investigation of ceRNA regulatory networks in trophoblast cells and application of ceRNA in prediction of preeclampsia

    • Principal Investigator
      Takizawa Toshihiro
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      Nippon Medical School
  •  The comprehensive microRNA analysis and an etiologic study for early-onset preeclampsia

    • Principal Investigator
      Takahashi Hironori
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      Jichi Medical University
  •  The research of imflammasome system in preeclampsia using STOX1 transgenic mice.

    • Principal Investigator
      SUZUKI HIROTADA
    • Project Period (FY)
      2014 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      Jichi Medical University
  •  Elucidation of the roles of placental microRNAs in the pathogenesis of preeclampsia and identification of novel prognostic factors for preeclampsia

    • Principal Investigator
      TAKIZAWA Toshihiro
    • Project Period (FY)
      2012 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      Nippon Medical School
  •  Validation of the prediction of preeclampsia within 4 weeks using the onset threshold of plasma sFlt-1/PlGF ratioPrincipal Investigator

    • Principal Investigator
      Ohkuchi Akihide
    • Project Period (FY)
      2012 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      Jichi Medical University
  •  Prospective study for detecting risk factors ineluding serum placental growth factor (PIGT) for the occurrence ofearly onset preeclampsiaPrincipal Investigator

    • Principal Investigator
      OHKUCHI Akihide
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      Jichi Medical University
  •  Ultrastructural enzymehistochemical and cell-biological analysis of the preterm dilivery -relationship between fetal cells and preterm delivery-

    • Principal Investigator
      MATSUBARA Shigeki
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      JICHI MEDICAL SCHOOL

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2007 2004 2003 Other

All Journal Article Presentation Book

  • [Book] MicroRNA. In: Preeclampsia: Basic, Genomic, and Clinical (Series Title: Comprehensive Gynecology and Obstetrics)2018

    • Author(s)
      Toshihiro Takizawa, Akihide Ohkuchi, Shigeki Matsubara, Toshiyuki Takeshita, Shigeru Saito
    • Total Pages
      16
    • Publisher
      Springer Singapore
    • ISBN
      9789811058912
    • Data Source
      KAKENHI-PROJECT-17K11256
  • [Journal Article] BeWo exomeres are enriched for bioactive extracellular placenta-specific C19MC miRNAs2024

    • Author(s)
      Noguchi Syunya、Tozawa Shohei、Sakurai Takanobu、Ohkuchi Akihide、Takahashi Hironori、Fujiwara Hiroyuki、Takizawa Toshihiro
    • Journal Title

      Journal of Reproductive Immunology

      Volume: 161 Pages: 104187-104187

    • DOI

      10.1016/j.jri.2023.104187

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22K16843, KAKENHI-PROJECT-20K09611
  • [Journal Article] Cytoplasmic and nuclear DROSHA in human villous trophoblasts2024

    • Author(s)
      Noguchi Syunya、Ohkura Sadayuki、Negishi Yasuyuki、Tozawa Shohei、Takizawa Takami、Morita Rimpei、Takahashi Hironori、Ohkuchi Akihide、Takizawa Toshihiro
    • Journal Title

      Journal of Reproductive Immunology

      Volume: 162 Pages: 104189-104189

    • DOI

      10.1016/j.jri.2023.104189

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22K16843, KAKENHI-PROJECT-22K07140, KAKENHI-PROJECT-20K09611
  • [Journal Article] 臨床編:産科 妊娠高血圧症候群:発症予知:17β-dehydrogenase2022

    • Author(s)
      大口 昭英、瀧澤 俊広
    • Journal Title

      周産期医学

      Volume: 52 Pages: 55-60

    • Data Source
      KAKENHI-PROJECT-20K09611
  • [Journal Article] Non-coding RNAs and prediction of preeclampsia in the first trimester of pregnancy2022

    • Author(s)
      Manabu Ogoyama, Hironori Takahashi, Hirotada Suzuki, Akihide Ohkuchi, Hiroyuki Fujiwara, Toshihiro Takizawa
    • Journal Title

      Cells

      Volume: 11 Issue: 15 Pages: 2428-2428

    • DOI

      10.3390/cells11152428

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K09611, KAKENHI-PROJECT-22K16863
  • [Journal Article] LncRNA H19-derived miR-675-5p accelerates the invasion of extravillous trophoblast cells by inhibiting GATA2 and subsequently activating matrix metalloproteinases2021

    • Author(s)
      Ogoyama M, Ohkuchi A, Takahashi H, Zhao D, Matsubara S, Takizawa T
    • Journal Title

      Int J Mol Sci

      Volume: 22 Issue: 3 Pages: 1237-1237

    • DOI

      10.3390/ijms22031237

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K09611, KAKENHI-PROJECT-19K18650
  • [Journal Article] Difficulty of predicting early-onset super-imposed preeclampsia in pregnant women with hemodialysis due to diabetic nephropathy by serum levels of sFlt-1, PlGF, and sEng2020

    • Author(s)
      Morisawa Hiroyuki、Hirashima Chikako、Sano Miho、Nagayama Shiho、Takahashi Hironori、Shirasuna Koumei、Ohkuchi Akihide
    • Journal Title

      CEN Case Rep

      Volume: 9 Issue: 2 Pages: 101-105

    • DOI

      10.1007/s13730-019-00435-y

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K11256
  • [Journal Article] Temporary hypertension and white coat hypertension in the first trimester as risk factors for preeclampsia2019

    • Author(s)
      Ohkuchi A, Hirashima C, Arai R, Takahashi K, Suzuki H, Ogoyama M, Nagayama S, Takahashi H, Baba Y, Usui R, Shirasuna K, Matsubara S
    • Journal Title

      Hypertens Res

      Volume: 42 Issue: 12 Pages: 2002-2012

    • DOI

      10.1038/s41440-019-0307-6

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K11247, KAKENHI-PROJECT-17K11256
  • [Journal Article] Markedly higher sFlt-1/PlGF ratio in a woman with acute fatty liver of pregnancy compared with HELLP syndrome2019

    • Author(s)
      Suzuki H, Nagayama S, Hirashima C, Takahashi K, Takahashi H, Ogoyama M, Nagayama M, Shirasuna K, Matsubara S, Ohkuchi A
    • Journal Title

      J Obstet Gynaecol Res

      Volume: 45 Issue: 1 Pages: 96-103

    • DOI

      10.1111/jog.13786

    • Data Source
      KAKENHI-PROJECT-17K11256
  • [Journal Article] 【妊娠高血圧症候群-PIHからHDPへ】妊娠高血圧腎症の発症原因:sFlt-1、PlGF2019

    • Author(s)
      大口昭英,平嶋周子,鈴木寛正
    • Journal Title

      産科と婦人科

      Volume: 86 Pages: 187-193

    • Data Source
      KAKENHI-PROJECT-17K11256
  • [Journal Article] Extravillous trophoblast invasion accelerated by WNT3A, 5A, and 10B via CD442019

    • Author(s)
      Takahashi H, Ogoyama M, Nagayama S, Suzuki H, Ohkuchi A, Matsubara S, Takizawa T
    • Journal Title

      The Journal of Maternal-Fetal & Neonatal Medicine

      Volume: 印刷中 Issue: 20 Pages: 1-9

    • DOI

      10.1080/14767058.2019.1684891

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K18650, KAKENHI-PROJECT-17K11256
  • [Journal Article] Short-Term Prediction of Adverse Outcomes Using the sFlt-1 (Soluble fms-Like Tyrosine Kinase 1)/PlGF (Placental Growth Factor) Ratio in Asian Women With Suspected Preeclampsia2019

    • Author(s)
      Bian Xuming、Biswas Arijit、Huang Xianghuang、Lee Kyoung Jin、Li Thomas Kwok-To、Masuyama Hisashi、Ohkuchi Akihide、Park Joong Shin、Saito Shigeru、Tan Kok Hian、Yamamoto Tatsuo、Dietl Angela、Grill Sonja、Verhagen-Kamerbeek Wilma D.J.、Shim Jae-Yoon、Hund Martin
    • Journal Title

      Hypertension

      Volume: 74 Issue: 1 Pages: 164-172

    • DOI

      10.1161/hypertensionaha.119.12760

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K11256
  • [Journal Article] Oxygen concentration modulates cellular senescence and autophagy in human trophoblast cells2018

    • Author(s)
      Seno K, Tanikawa N, Takahashi H, Ohkuchi A, Suzuki H, Matsubara S, Iwata H, Kuwayama T, Shirasuna K
    • Journal Title

      Am J Reprod Immunol

      Volume: 79 Issue: 6

    • DOI

      10.1111/aji.12826

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K07783, KAKENHI-PROJECT-16K11103, KAKENHI-PROJECT-26462498
  • [Journal Article] Outline of the new definition and classification of “Hypertensive Disorders of Pregnancy (HDP)”; a revised JSSHP statement of 20052018

    • Author(s)
      Watanabe K, Matsubara K, Nakamoto O, Ushijima J, Ohkuchi A, Koide K, Makino S, Mimura K, Morikawa M, Naruse K, Tanaka K, Nohira T, Metoki H, Kawabata I, Takeda S, Seki H, Takagi K, Yamasaki M, Ichihara A, Kimura T, Saito S
    • Journal Title

      Hypertension Research in Pregnancy

      Volume: 6 Issue: 2 Pages: 33-37

    • DOI

      10.14390/jsshp.HRP2018-014

    • NAID

      130007626658

    • ISSN
      2187-5987, 2187-9931
    • Year and Date
      2018-11-30
    • Language
      English
    • Data Source
      KAKENHI-PROJECT-17K11256
  • [Journal Article] Increased serum levels of sFlt-1/PlGF ratio in preeclamptic women with onset at < 32 weeks compared with > 32 weeks2018

    • Author(s)
      Suzuki H, Hirashima C, Nagayama S, Takahashi K, Yamamoto T, Matsubara S, Ohkuchi A
    • Journal Title

      Pregnancy Hypertens

      Volume: 12 Pages: 96-103

    • DOI

      10.1016/j.preghy.2018.03.008

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K11256
  • [Journal Article] 今月の臨床 完全マスター! 妊娠高血圧症候群─PIHからHDPへ 妊娠高血圧症候群の予防と治療 家庭血圧測定の有用性2018

    • Author(s)
      大口昭英
    • Journal Title

      臨床婦人科産科

      Volume: 72 Issue: 7 Pages: 659-663

    • DOI

      10.11477/mf.1409209439

    • ISSN
      0386-9865, 1882-1294
    • Year and Date
      2018-07-10
    • Data Source
      KAKENHI-PROJECT-17K11256
  • [Journal Article] Galectin-1 as a novel risk factor for both gestational hypertension and preeclampsia, specifially its expression at a low level in the second trimester and a high level after onset2018

    • Author(s)
      Hirashima C, Ohkuchi A, Nagayama S, Suzuki H, Takahashi K, Ogoyama M, Takahashi H, Shirasuna K, Matsubara S
    • Journal Title

      Hypertens Res

      Volume: 41 Issue: 1 Pages: 45-52

    • DOI

      10.1038/hr.2017.85

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K11256
  • [Journal Article] 特集 PIHからHDPへ-妊娠高血圧症候群up to date- 4. 妊娠初期における妊娠高血圧腎症の発症予知と予防2018

    • Author(s)
      大口昭英
    • Journal Title

      産婦人科の実際

      Volume: 67 Issue: 6 Pages: 613-616

    • DOI

      10.18888/sp.0000000456

    • ISSN
      0558-4728
    • Year and Date
      2018-06-01
    • Data Source
      KAKENHI-PROJECT-17K11256
  • [Journal Article] Serum soluble LIGHT in the early third trimester as a novel biomarker for predicting late-onset preeclampsia2018

    • Author(s)
      Hirashima C, Ohmaru-Nakanishi T, Nagayama S, Takahashi K, Suzuki H, Takahashi H, Usui R, Shirasuna K, Matsubara S, Ohkuchi A
    • Journal Title

      Pregnancy Hypertens

      Volume: 14 Pages: 174-176

    • DOI

      10.1016/j.preghy.2018.10.004

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K11256
  • [Journal Article] Prediction and prevention of hypertensive disorders of pregnancy.2017

    • Author(s)
      Ohkuchi A, Hirashima C, Takahashi K, Suzuki H, Matsubara S.
    • Journal Title

      Hypertens Res

      Volume: 40 Issue: 1 Pages: 5-14

    • DOI

      10.1038/hr.2016.107

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24592482
  • [Journal Article] Advanced glycation end products regulate interleukin-1β production in human placenta.2017

    • Author(s)
      Seno K, Sase S, Ozeki A, Takahashi H, Ohkuchi A, Suzuki H, Matsubara S, Iwata H, Kuwayama T, Shirasuna K.
    • Journal Title

      J Reprod Dev

      Volume: 印刷中

    • NAID

      130005982808

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26462498
  • [Journal Article] Endogenous and exogenous miR-520c-3p modulates CD44-mediated extravillous trophoblast invasion2017

    • Author(s)
      Takahashi H, Ohkuchi A, Kuwata T, Usui R, Baba Y, Suzuki H, Chaw Kyi TT, Matsubara S, Saito S, Takizawa T
    • Journal Title

      Placenta

      Volume: 50 Pages: 25-31

    • DOI

      10.1016/j.placenta.2016.12.016

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15H04980, KAKENHI-PROJECT-24592482, KAKENHI-PROJECT-16K11103
  • [Journal Article] Advanced glycation end products regulate interleukin-1β production in human placenta2017

    • Author(s)
      Seno K, Sase S, Ozeki A, Takahashi H, Ohkuchi A, Suzuki H, Matsubara S, Iwata H, Kuwayama T, Shirasuna K
    • Journal Title

      J. Reprod. Dev.

      Volume: 63 Issue: 4 Pages: 401-408

    • DOI

      10.1262/jrd.2017-032

    • NAID

      130005982808

    • ISSN
      0916-8818, 1348-4400
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K07783, KAKENHI-PROJECT-26462498
  • [Journal Article] Isolated gestational proteinuria preceding the diagnosis of preeclampsia - an observational study.2016

    • Author(s)
      Yamada T, Obata-Yasuoka M, Hamada H, Baba Y, Ohkuchi A, Yasuda S, Kawabata K, Minakawa S, Hirai C, Kusaka H, Murabayashi N, Inde Y, Nagura M, Umazume T, Itakura A, Maeda M, Sagawa N, Ohno Y, Kataoka S, Fujimori K, Kudo Y, Ikeda T, Nakai A, Minakami H.
    • Journal Title

      Acta Obstet Gynecol Scand

      Volume: 95 Issue: 9 Pages: 1048-54

    • DOI

      10.1111/aogs.12915

    • NAID

      120006337755

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24592482
  • [Journal Article] AGEs and HMGB1 Increase Inflammatory Cytokine Production from Human Placental Cells, Resulting in an Enhancement of Monocyte Migration.2016

    • Author(s)
      Shirasuna K, Seno K, Ohtsu A, Shiratsuki S, Ohkuchi A, Suzuki H, Matsubara S, Nagayama S, Iwata H, Kuwayama T.
    • Journal Title

      Am J Reprod Immunol

      Volume: 75 Issue: 5 Pages: 557-568

    • DOI

      10.1111/aji.12506

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24592482, KAKENHI-PROJECT-15K07783
  • [Journal Article] Urinary protein-to-creatinine ratio indicative of significant proteinuria in normotensive pregnant women.2016

    • Author(s)
      Baba Y, Ohkuchi A, Usui R, Takahashi H, Matsubara S.
    • Journal Title

      J Obstet Gynaecol Res

      Volume: 42 Issue: 7 Pages: 784-8

    • DOI

      10.1111/jog.13000

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24592482
  • [Journal Article] Palmitic acid induces interleukin-1β secretion via NLRP3 inflammasomes and inflammatory responses through ROS production in human placental cells.2016

    • Author(s)
      Shirasuna K, Takano H, Seno K, Ohtsu A, Karasawa T, Takahashi M, Ohkuchi A, Suzuki H, Matsubara S, Iwata H, Kuwayama T.
    • Journal Title

      J Reprod Immunol

      Volume: 116 Pages: 104-112

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26462498
  • [Journal Article] AGEs and HMGB1 increase inflammatory cytokine production from human placental cells, resulting in an enhancement of monocyte migration.2016

    • Author(s)
      Shirasuna K, Seno K, Ohtsu A, Shiratsuki S, Ohkuchi A, Suzuki H, Matsubara S, Nagayama S, Iwata H, Kuwayama T.
    • Journal Title

      Am J Reprod Immunol

      Volume: 75 Pages: 557-568

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26462498
  • [Journal Article] Changes in Central Hemodynamics in Women With Hypertensive Pregnancy Between Before and After Delivery.2016

    • Author(s)
      Fukushima T, Eguchi K, Ohkuchi A, Miyashita H, Kario K.
    • Journal Title

      J Clin Hypertens (Greenwich)

      Volume: 18 Issue: 4 Pages: 329-36

    • DOI

      10.1111/jch.12670

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24592482
  • [Journal Article] The Frequency of peripheral blood CD4+FoxP3+ regulatory T cells in women with pre-eclampsia and those with high-risk factors for pre-eclampsia.2015

    • Author(s)
      Shiho Nagayama, Akihide Ohkuchi, Koumei Shirasunab, Kayo Takahashi, Hirotada Suzuki, Chikako Hirashima, Asuka Sakata, Satoshi Nishimura, Masafumi Takahashi, Shigeki Matsubara
    • Journal Title

      Hypertens Pregnancy

      Volume: 34 Pages: 443-455

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24390383
  • [Journal Article] NLRP3 deficiency improves angiotensin II-induced hypertension but not fetal growth restriction during pregnancy.2015

    • Author(s)
      Shirasuna K, Karasawa T, Usui F, Kobayashi M, Komada T, Kimura A, Ohkuchi A, Taniguchi S, Takahashi M.
    • Journal Title

      Endocrinology

      Volume: 156 Issue: 11 Pages: 4281-4292

    • DOI

      10.1210/en.2015-1408

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K08022, KAKENHI-PROJECT-15K09146, KAKENHI-PROJECT-24592482, KAKENHI-PROJECT-26461386
  • [Journal Article] 網羅的マイクロRNA解析による妊娠高血圧症候群の機序の解明(特集 オミックスが拓く生殖医学の未来)2015

    • Author(s)
      瀧澤俊広、大口昭英
    • Journal Title

      HORMONE FRONTIER IN GYNECOLOGY

      Volume: 22 Pages: 53-58

    • Data Source
      KAKENHI-PROJECT-24390383
  • [Journal Article] Moderate Hypoxia Down-Regulates Interleukin-6 Secretion and TLR4 Expression in Human Sw.71 Placental Cells.2015

    • Author(s)
      Shirasuna K, Shimamura N, Seno K, Ohtsu A, Shiratsuki S, Ohkuchi A, Suzuki H, Matsubara S, Nagayama S, Iwata H, Kuwayama T.
    • Journal Title

      Cell Physiol Biochem

      Volume: 36 Issue: 6 Pages: 2149-2160

    • DOI

      10.1159/000430181

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-24592482, KAKENHI-PROJECT-26462498
  • [Journal Article] Maternal peripheral blood natural killer cells incorporate placenta-associated microRNAs during pregnancy.2015

    • Author(s)
      Ishida Y, Zhao D, Ohkuchi A, Kuwata T, Yoshitake H, Yuge K, Takizawa T, Matsubara S, Suzuki M, Saito S, Takizawa T
    • Journal Title

      Int J Mol Med.

      Volume: 35 Issue: 6 Pages: 1511-1524

    • DOI

      10.3892/ijmm.2015.2157

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-23390386, KAKENHI-PROJECT-24592609, KAKENHI-PROJECT-24592482, KAKENHI-PROJECT-15H04980, KAKENHI-PROJECT-24390383
  • [Journal Article] Ambulatory BP monitoring and clinic BP in predicting small-for-gestational-age infants during pregnancy2015

    • Author(s)
      Eguchi K, Ohmaru T, Ohkuchi A, Hirashima C, Takahashi K, Suzuki H, Kario K
    • Journal Title

      J Hum Hypertens

      Volume: in press Issue: 1 Pages: 62-7

    • DOI

      10.1038/jhh.2015.20

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26293192, KAKENHI-PROJECT-24592482
  • [Journal Article] Urinary protein-to-creatinine ratio in pregnant women after dipstick testing: prospective observational study.2015

    • Author(s)
      Baba Y, Yamada T, Obata-Yasuoka M, Yasuda S, Ohno Y, Kawabata K, Minakawa S, Hirai C, Kusaka H, Murabayashi N, Inde Y, Nagura M, Hamada H, Itakura A, Ohkuchi A, Maeda M, Sagawa N, Nakai A, Kataoka S, Fujimori K, Kudo Y, Ikeda T, Minakami H.
    • Journal Title

      BMC Pregnancy Childbirth

      Volume: 14 Issue: 1 Pages: 331-331

    • DOI

      10.1186/s12884-015-0776-9

    • NAID

      120007128510

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24592482
  • [Journal Article] The Frequency of Peripheral Blood CD4+FoxP3+ Regulatory T Cells in Women With Pre-eclampsia and Those With High-risk Factors for Pre-eclampsia.2015

    • Author(s)
      Nagayama S, Ohkuchi A, Shirasuna K, Takahashi K, Suzuki H, Hirashima C, Sakata A, Nishimura S, Takahashi M, Matsubara S.
    • Journal Title

      Hypertens Pregnancy

      Volume: 34 Issue: 4 Pages: 443-455

    • DOI

      10.3109/10641955.2015.1065884

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24592482
  • [Journal Article] 胎盤由来microRNA : 妊娠高血圧症候群との関連(特集 胎盤のバイオマーカー)2015

    • Author(s)
      瀧澤俊広、大口昭英、Banyar Than Naing
    • Journal Title

      産科と婦人科

      Volume: 82 Pages: 1011-1016

    • NAID

      40020568053

    • Data Source
      KAKENHI-PROJECT-24390383
  • [Journal Article] 網羅的マイクロRNA解析による妊娠高血圧症候群の機序の解明(特集 オミックスが拓く生殖医学の未来)2015

    • Author(s)
      瀧澤俊広、大口昭英
    • Journal Title

      HORMONE FRONTIER IN GYNECOLOGY

      Volume: 22 Pages: 53-58

    • Data Source
      KAKENHI-PROJECT-24390383
  • [Journal Article] The Role of the Father in the Occurrence of Preeclampsia2014

    • Author(s)
      Shiho Nagayama, Akihide Ohkuchi, RieUsui, Shigeki Matsubara, and Mitsuaki Suzuki
    • Journal Title

      Med J Obstet Gynecol

      Volume: 2 Pages: 1029-1029

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24592482
  • [Journal Article] Differential Expression of ADAM (a Disintegrin and Metalloproteinase) Genes between Human First Trimester Villous and Extravillous Trophoblast Cells2014

    • Author(s)
      Hironori Takahashi, Kazuya Yuge, Shigeki Matsubara, Akihide Ohkuchi, Tomoyuki Kuwata, Rie Usui, Mitsuaki Suzuki, Toshihiro Takizawa
    • Journal Title

      Journal of Nippon Medical School

      Volume: 81 Issue: 3 Pages: 122-129

    • DOI

      10.1272/jnms.81.122

    • NAID

      130004147298

    • ISSN
      1345-4676, 1347-3409
    • Language
      English
    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24390383
  • [Journal Article] Maternal manifestation of Ballantyne's syndrome occurring concomitantly with the development of fetal congenital mesoblastic nephroma.2014

    • Author(s)
      Takahashi H, Matsubara S, Kuwata T, Ohkuchi A, Mukoda Y, Saito K, Usui R, Suzuki M
    • Journal Title

      J Obstet Gynaecol Res

      Volume: 40 Issue: 4 Pages: 1114-7

    • DOI

      10.1111/jog.12286

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24592482
  • [Journal Article] Human exosomal placenta-associated miR-517a-3p modulates the expression of PRKG1 mRNA in Jurkat cells2014

    • Author(s)
      Saori Kambe, Hiroshi Yoshitake, Kazuya Yuge, Yoichi Ishida, Md. Moksed Ali, Takami Takizawa, Tomoyuki Kuwata, Akihide Ohkuchi, Shigeki Matsubara, Mitsuaki Suzuki, Toshiyuki Takeshita, Shigeru Saito, Toshihiro Takizawa
    • Journal Title

      Biol Reprod

      Volume: 91 Pages: 129-129

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24390383
  • [Journal Article] Differential expression of ADAM (a disintegrin and metalloproteinase) genes between human first trimester villous and extravillous trophoblast cells.2014

    • Author(s)
      Takahashi H, Yuge K, Matsubara S, Ohkuchi A, Kuwata T, Usui R, Suzuki M, Takizawa T.
    • Journal Title

      J Nippon Med S

      Volume: 81 Pages: 122-129

    • NAID

      130004147298

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24592482
  • [Journal Article] Human exosomal placenta-associated miR-517a-3p modulates the expression of PRKG1 mRNA in Jurkat cells.2014

    • Author(s)
      Kambe S, Yoshitake H, Yuge K, Ishida Y, Moksed A, Takizawa T, Kuwata T, Ohkuchi A, Matsubara S, Suzuki M, Takeshita T, Saito S, Takizawa T
    • Journal Title

      Biol Reprod

      Volume: 91 Issue: 5 Pages: 129-129

    • DOI

      10.1095/biolreprod.114.121616

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390386, KAKENHI-PROJECT-24592482, KAKENHI-PROJECT-24592609
  • [Journal Article] Prediction of Early-Onset Preeclampsia Using Uterine Artery Doppler2014

    • Author(s)
      Akihide Ohkuchi, Kayo Takahashi, Chikako Hirashima, RieUsui, Shigeki Matsubara and Mitsuaki Suzuki
    • Journal Title

      Med J Obset Gynecol

      Volume: 2 Pages: 1026-1026

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24592482
  • [Journal Article] Risk of Preeclampsia in Women with CKD, Dialysis or Kidney Transplantation2014

    • Author(s)
      Noriko Hirose, Akihide Ohkuchi, RieUsui, Shigeki Matsubara, and Mitsuaki Suzuki
    • Journal Title

      Med J Obstet Gynecol

      Volume: 2 Pages: 1028-1028

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24592482
  • [Journal Article] Changes in expression of vascular endothelial growth factor D-related genes in placental mesenchymal dysplasia2014

    • Author(s)
      Hironori Takahashi, Shigeki Matsubara, Tomoyuki Kuwata, Miyuki Saruyama, Rie Usui, Akihide Ohkuchi, Toshihiro Takizawa, Mitsuaki Suzuki
    • Journal Title

      J Obstet Gynaecol Res

      Volume: 40 Issue: 4 Pages: 1145-1149

    • DOI

      10.1111/jog.12291

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24390383, KAKENHI-PROJECT-24592482
  • [Journal Article] Risk Factors Associated with the Occurrence of Preeclampsia in Women with Twin Pregnancies: Mini Review2014

    • Author(s)
      Akihide Ohkuchi
    • Journal Title

      Med J Obstet Gynecol

      Volume: 2 Pages: 1027-1027

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24592482
  • [Journal Article] Increased antiangiogenetic factors in severe proteinuria without hypertension in pregnancy: is kidney biopsy necessary?2014

    • Author(s)
      Ohmaru T, Ohkuchi A, Muto S, Hirashima C, Matsubara S, Suzuki M
    • Journal Title

      CEN Case Rep

      Volume: 3 Issue: 1 Pages: 86-89

    • DOI

      10.1007/s13730-013-0092-z

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24592482
  • [Journal Article] Extravillous trophoblast cell invasion is promoted by the CD44-hyaluronic acid interaction2014

    • Author(s)
      Hironori Takahashi, Takami Takizawa, Shigeki Matsubara, Akihide Ohkuchi, Tomoyuki Kuwata, Rie Usui, Hisanori Matsumoto, Yukiyasu Sato, Hiroshi Fujiwara, Aikou Okamoto, Mitsuaki Suzuki, Toshihiro Takizawa
    • Journal Title

      Placenta

      Volume: 35 Issue: 3 Pages: 163-170

    • DOI

      10.1016/j.placenta.2013.12.009

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24390383, KAKENHI-PROJECT-24592470, KAKENHI-PROJECT-25670702, KAKENHI-PROJECT-26293358
  • [Journal Article] Additive effects of mean blood pressure and bilateral notching in the second trimester on subsequent angiogenesis-related factors.2014

    • Author(s)
      Hirashima C, Ohkuchi A, Takahashi K, Suzuki H, Matsuda Y, Matsubara S, Suzuki M
    • Journal Title

      Hypertens Res

      Volume: 37 Issue: 1 Pages: 76-81

    • DOI

      10.1038/hr.2013.88

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24592482
  • [Journal Article] Animal Models of Preeclampsia: Insight into Possible Biomarker Candidates for Predicting Preeclampsia2014

    • Author(s)
      Hirotada Suzuki, Akihide Ohkuchi, Koumei Shirasuna, Hironori Takahashi, Rie Usui, Shigeki Matsubara and Mitsuaki Suzuki
    • Journal Title

      Med J Obstet Gynecol

      Volume: 2 Pages: 1031-1031

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24592482
  • [Journal Article] A novel three-step approach for predicting the imminent onset of preeclampsia within 4 weeks after blood sampling at 19-31 weeks of gestation.2014

    • Author(s)
      Hirashima C, Ohkuchi A, Takahashi K, Suzuki H, Matsubara S, Suzuki M.
    • Journal Title

      Hypertens Res

      Volume: 37 Issue: 6 Pages: 519-525

    • DOI

      10.1038/hr.2014.31

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24592482
  • [Journal Article] Recurrence Risk of Hypertensive Disease in Pregnancy2014

    • Author(s)
      Kayo Takahashi, Akihide Ohkuchi, Mami Kobayashi, Shigeki Matsubara, and Mitsuaki Suzuki
    • Journal Title

      Med J Obset Gynecol

      Volume: 2 Pages: 1023-1023

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24592482
  • [Journal Article] Prediction of Early-Onset Preeclampsia Using Angiogenesis-Related Factors2014

    • Author(s)
      Chikako Hirashima, Akihide Ohkuchi, Kayo Takahashi, Rie Usui, Shigeki Matsubara and Mitsuaki Suzuki
    • Journal Title

      Med J Obstet Gynecol

      Volume: 2 Pages: 1025-1025

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24592482
  • [Journal Article] Importance of Chromosome 19 miRNA Cluster in Pregnancy2014

    • Author(s)
      Hironori Takahashi, Akihide Ohkuchi, Rie Usui, Toshihiro Takizawa, Shigeki Matsubara and Mitsuaki Suzuki
    • Journal Title

      Med J Obstet Gynecol

      Volume: 2 Pages: 1032-1032

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24592482
  • [Journal Article] Adenomyomectomy, curettage, and then uterine artery pseudoaneurysm occupying the entire uterine cavity.2013

    • Author(s)
      Matsubara S, Usui R, Sato T, Kuwata T, Ohkuchi A, Nakata M.
    • Journal Title

      J Obstet Gynaecol Res

      Volume: 39 Issue: 5 Pages: 1103-6

    • DOI

      10.1111/jog.12021

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24592482
  • [Journal Article] Biophysical interaction between blood pressure and uterine artery Doppler for the occurrence of early-onset preeclampsia: A prospective cohort study.2013

    • Author(s)
      Takahashi K, Ohkuchi A, Suzuki H, Usui R, Kuwata T, Shirasuna K, Matsubara S, Suzuki M
    • Journal Title

      Pregnancy Hypertens

      Volume: 3 Issue: 4 Pages: 270-277

    • DOI

      10.1016/j.preghy.2013.07.006

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24592482
  • [Journal Article] Committee report on cerebrovascular disorders, including eclampsia and emergency medical services, of the Japan Society for the Study of Hypertension in Pregnancy2013

    • Author(s)
      Suzuki Y, Adachi T, Ohno Y, Matsuda H, Naruse K, Metoki H, Nakai Y, Nakamoto O, Watanabe K, Ohkuchi A, Yamamoto T
    • Journal Title

      Hypertension Research in Pregnancy

      Volume: 1 Issue: 1 Pages: 8-12

    • DOI

      10.14390/jsshp.1.8

    • NAID

      130005002838

    • ISSN
      2187-5987, 2187-9931
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23592408, KAKENHI-PROJECT-23791848, KAKENHI-PROJECT-24592482
  • [Journal Article] Uterine compression sutures for postpartum hemorrhage: an overview.2013

    • Author(s)
      Matsubara S, Yano H, Ohkuchi A, Kuwata T, Usui R, Suzuki M.
    • Journal Title

      Acta Obstet Gynecol Scand

      Volume: 92 Issue: 4 Pages: 378-85

    • DOI

      10.1111/aogs.12077

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24592482
  • [Journal Article] Important surgical measures and techniques at cesarean hysterectomy for placenta previa accreta.2013

    • Author(s)
      Matsubara S, Yano H, Ohkuchi A, Kuwata T, Usui R, Suzuki M.
    • Journal Title

      Acta Obstet Gynecol Scand

      Volume: 92 Issue: 4 Pages: 372-7

    • DOI

      10.1111/aogs.12074

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24592482
  • [Journal Article] Onset threshold of the plasma levels of soluble fms-like tyrosine kinase 1/placental growth factor ratio for predicting the imminent onset of preeclampsia within 4 weeks after blood sampling at 19-31 weeks of gestation.2013

    • Author(s)
      Ohkuchi A, Hirashima C, Takahashi K, Suzuki H, Matsubara S, Suzuki M
    • Journal Title

      Hypertens Res

      Volume: 36 Issue: 12 Pages: 1073-80

    • DOI

      10.1038/hr.2013.95

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24592482
  • [Journal Article] Extravillous trophoblast cell invasion is promoted by the CD44-hyaluronic acid interaction.2013

    • Author(s)
      Takahashi H, Takizawa T, Matsubara S, Ohkuchi A, Kuwata T, Usui R, Matsumoto H, Sato Y, Fujiwara H, Okamoto A, Suzuki M, Takizawa T
    • Journal Title

      Placenta

      Volume: 35 Pages: 163-70

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24592482
  • [Journal Article] 'Holding the cervix' technique for post-partum hemorrhage for achieving hemostasis as well as preventing prolapse of an intrauterine balloon.2013

    • Author(s)
      Matsubara S, Kuwata T, Usui R, Ohkuchi A.
    • Journal Title

      J Obstet Gynaecol Res

      Volume: 39 Issue: 5 Pages: 1116-7

    • DOI

      10.1111/jog.12019

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24592482
  • [Journal Article] Plasma level of hydroxysteroid (17-β) dehydrogenase 1 in the second trimester is an independent risk factor for predicting preeclampsia after adjusting for the effects of mean blood pressure, bilateral notching and plasma level of soluble fms-like tyrosine kinase 1/placental growth factor ratio.2012

    • Author(s)
      Ohkuchi A, Ishibashi O, Hirashima C, Takahashi K, Matsubara S, Takizawa T, Suzuki M.
    • Journal Title

      Hypertens Res

      Volume: 35 Issue: 12 Pages: 1152-1158

    • DOI

      10.1038/hr.2012.109

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390386, KAKENHI-PROJECT-24390383, KAKENHI-PROJECT-24592482
  • [Journal Article] Oral health care during pregnancy: four aims may be too many.2012

    • Author(s)
      Matsubara S, Kuwata T, Ohkuchi A.
    • Journal Title

      Rural Remote Health

      Volume: 12 Pages: 2294-2294

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24592482
  • [Journal Article] Establishing reference values for mean notch depth index, pulsatility index and resistance index in the uterine artery at 16-23 weeks' gestation.2012

    • Author(s)
      Takahashi K, Ohkuchi A, Hirashima C, Matsubara S, Suzuki M.
    • Journal Title

      J Obstet Gynaecol Res

      Volume: 38 Issue: 11 Pages: 1275-85

    • DOI

      10.1111/j.1447-0756.2012.01864.x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24592482
  • [Journal Article] Initial dose of vancomycin based on body weight and creatinine clearance to minimize inadequate trough levels in Japanese adults.2012

    • Author(s)
      Maki N, Ohkuchi A, Tashiro Y, Kim MR, Le M, Sakamoto T, Matsubara S, Hakamata Y.
    • Journal Title

      Eur J Clin Microbiol Infect Dis

      Volume: 31 Issue: 10 Pages: 2537-43

    • DOI

      10.1007/s10096-012-1593-y

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24592482
  • [Journal Article] 妊娠高血圧腎症と可溶性Flt-12007

    • Author(s)
      大口 昭英、松原 茂樹
    • Journal Title

      血瞥医学 8

      Pages: 19-27

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18591809
  • [Journal Article] Alterations in placental growth factor levels before and after the onset of preeclampsia are more pronounced in women with earty onset severe preeclampsia2007

    • Author(s)
      Ohkuchi A, et. al.
    • Journal Title

      Hypertension Research 30

      Pages: 151-159

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18591809
  • [Journal Article] 妊娠高血圧腎症と可溶性Flt-12007

    • Author(s)
      大口 昭英、松原 茂樹
    • Journal Title

      血管医学 8

      Pages: 19-27

    • Data Source
      KAKENHI-PROJECT-18591809
  • [Journal Article] Alterations in Placental Growth Factor Levels before and after the Onset of Preeclampsia Are More Pronounced in Women with Early Onset Severe Preeclampsia2007

    • Author(s)
      Ohkuchi A.
    • Journal Title

      Hypertension Research Vol.30, No.2

      Pages: 151-159

    • NAID

      10018831012

    • Data Source
      KAKENHI-PROJECT-18591809
  • [Journal Article] Alterations in placental growth factor levels before and after the onset of preeclampsia are more pronounced in women with early onset severe preeclampsia2007

    • Author(s)
      Ohkuchi A, et. al.
    • Journal Title

      Hypertension Research 30

      Pages: 151-159

    • NAID

      10018831012

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18591809
  • [Journal Article] The risk of birth defects in dichorionic twins conceived by assisted reproductive technology.2004

    • Author(s)
      Kuwata T, Matsubara S, Ohkuchi A, Watanabe T, Suzuki M et al.
    • Journal Title

      Twin Research 7

      Pages: 223-227

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15591775
  • [Journal Article] Hofbauer cell activation and its increased glucose-6-phosphate dehydrogenase activity in second-trimester spontaneous abortion.2003

    • Author(s)
      Matsubara S, Takayama T, Watanabe T, Ohkuchi A, Suzuki M et al.
    • Journal Title

      American Journal of Reproductive Immunology 49

      Pages: 202-209

    • Data Source
      KAKENHI-PROJECT-15591775
  • [Journal Article] Hofbauer cell activation and its increased glucose-6-phosphate dehydrogenase activity in second-trimester spontaneous abortion.2003

    • Author(s)
      Matsubara S, Takayama T, Watanabe T, Ohkuchi A, Suzuki et al.
    • Journal Title

      American Journal of Reproductive Immunology 49

      Pages: 202-209

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15591775
  • [Presentation] 血中エクソソーム量と妊娠高血圧腎症発症予知との関連性2024

    • Author(s)
      成見莉紗、鈴木寛正、小古山学、堀江健司、田村昂平、平嶋周子、高橋佳代、大口昭英、高橋宏典、藤原寛行
    • Organizer
      第76回日本産科婦人科学会学術講演会
    • Data Source
      KAKENHI-PROJECT-22K09646
  • [Presentation] ヒト胎盤絨毛栄養膜細胞から分泌される細胞外ナノ粒子と細胞外小胞の分子解剖学的解析2024

    • Author(s)
      野口 隼矢、斗澤 昇平、櫻井 孝信、添田 聡、高橋 宏典、大口 昭英、藤原 寛行、瀧澤 俊広
    • Organizer
      第129回日本解剖学会全国学術集会
    • Data Source
      KAKENHI-PROJECT-20K09611
  • [Presentation] 血中のエクソソーム濃度:正常妊婦の週数別推移と妊娠高血圧腎症妊婦との比較2023

    • Author(s)
      成見莉紗、鈴木寛正、小古山学、堀江健司、高橋佳代、大口昭英、高橋宏典、藤原寛行
    • Organizer
      第31回日本胎盤学会学術集会
    • Data Source
      KAKENHI-PROJECT-22K09646
  • [Presentation] Trophoblast cell line BeWo cell-derived nanoparticles contain a large amount of placenta-specific microRNAs and modify the gene expression of recipient immune cells (T lymphocyte cell line Jurkat cells).2023

    • Author(s)
      Syunya Noguchi, Shohei Tozawa, Takanobu Sakurai, Akihide Ohkuchi, Hironori Takahashi, Hiroyuki Fujiwara, Toshihiro Takizawa
    • Organizer
      1st Asian Congress for Reproductive Immunology (ACRI)
    • Data Source
      KAKENHI-PROJECT-20K09611
  • [Presentation] 栄養膜細胞から分泌されるナノ粒子由来胎盤特異的miRNAは免疫細胞に取り込まれる2023

    • Author(s)
      野口 隼矢、斗澤 昇平、高橋 宏典、大口 昭英、藤原 寛行、瀧澤 俊広
    • Organizer
      第75回日本産科婦人科学会学術講演会
    • Data Source
      KAKENHI-PROJECT-20K09611
  • [Presentation] 胎盤栄養膜細胞株(BeWo)由来細胞外粒子の解析2023

    • Author(s)
      野口 隼矢,斗澤 昇平,櫻井 孝信,高橋 宏典,大口 昭英,藤原 寛行,瀧澤 俊広
    • Organizer
      第128回日本解剖学会総会・全国学術集会
    • Data Source
      KAKENHI-PROJECT-20K09611
  • [Presentation] 非小胞型細胞外ナノ粒子は胎盤母体間コミュニケーションの新たな鍵となる輸送体である:BeWoを用いたモデル解析2023

    • Author(s)
      野口 隼矢、斗澤 昇平、櫻井 孝信、大口 昭英、高橋 宏典、藤原 寛行、瀧澤 俊広
    • Organizer
      第31回日本胎盤学会学術集会
    • Data Source
      KAKENHI-PROJECT-20K09611
  • [Presentation] 栄養膜細胞株BeWoを用いたウイルス感染における栄養膜細胞DROSHAの動態解析2023

    • Author(s)
      野口 隼矢、大倉 定之、根岸 靖幸、森田 林平、大口 昭英、高橋 宏典、瀧澤 俊広
    • Organizer
      第31回日本胎盤学会学術集会
    • Data Source
      KAKENHI-PROJECT-20K09611
  • [Presentation] 胎盤絨毛栄養膜細胞のmiRNA生合成酵素DROSHAに結合するRNA:fCLIP解析2023

    • Author(s)
      瀧澤 俊広、野口 隼矢、大倉 定之、根岸 靖幸、森田 林平、大口 昭英、高橋 宏典
    • Organizer
      第31回日本胎盤学会学術集会
    • Data Source
      KAKENHI-PROJECT-20K09611
  • [Presentation] 胎盤栄養膜細胞株BeWo由来ナノ粒子の形態・構成蛋白質解析2022

    • Author(s)
      野口 隼矢, 斗澤 昇平, 櫻井 孝信, 大口 昭英, 高橋 宏典, 藤原 寛行, 瀧澤 俊広
    • Organizer
      第127回日本解剖学会総会・全国学術集会
    • Data Source
      KAKENHI-PROJECT-20K09611
  • [Presentation] 胎盤栄養膜細胞株 BeWo 由来ナノ粒子の形態・構成蛋白質解析 WEB開催(オンデマンド配信)2022

    • Author(s)
      野口 隼矢,斗澤 昇平,櫻井 孝信,大口 昭英,高橋 宏典,藤原 寛行,瀧澤 俊広
    • Organizer
      第127回日本解剖学会総会・全国学術集会
    • Data Source
      KAKENHI-PROJECT-20K09611
  • [Presentation] 栄養膜細胞株BeWo細胞から分泌されるナノ粒子の特徴付け2022

    • Author(s)
      斗澤 昇平,野口 隼矢,櫻井 孝信,大口 昭英,高橋 宏典,藤原 寛行,瀧澤 俊広
    • Organizer
      第37回日本生殖免疫学会総会・学術集会
    • Data Source
      KAKENHI-PROJECT-20K09611
  • [Presentation] 栄養膜細胞株BeWo細胞から分泌されるエクソソームとナノ粒子の比較解析2022

    • Author(s)
      斗澤 昇平,野口 隼矢,櫻井 孝信,高橋 宏典,大口 昭英,藤原 寛行,瀧澤 俊広
    • Organizer
      第30回日本胎盤学会学術集会・第40回日本絨毛性疾患研究会
    • Data Source
      KAKENHI-PROJECT-20K09611
  • [Presentation] 栄養膜細胞から分泌されるナノ粒子の同定:BeWo細胞を用いた解析2022

    • Author(s)
      斗澤 昇平,野口 隼矢,櫻井 孝信,大口 昭英,高橋 宏典,藤原 寛行,瀧澤 俊広
    • Organizer
      第74回日本産科婦人科学会学術講演会
    • Data Source
      KAKENHI-PROJECT-20K09611
  • [Presentation] 胎盤絨毛栄養膜細胞miRNA生合成酵素DROSHAの局在2021

    • Author(s)
      瀧澤 俊広, 小古山 学, 高橋 宏典, 大口 昭英
    • Organizer
      第36回日本生殖免疫学会総会・学術集会
    • Data Source
      KAKENHI-PROJECT-20K09611
  • [Presentation] 絨毛外栄養膜細胞に高発現しているmiR-675-5pは転写調節因子GATA2の抑制を介してMMP13/MMP14の発現を上昇させ細胞浸潤を促進する2021

    • Author(s)
      小古山 学, 大口 昭英, 高橋 宏典, 松原 茂樹, 瀧澤 俊広
    • Organizer
      第73回日本産科婦人科学会学術講演会
    • Data Source
      KAKENHI-PROJECT-20K09611
  • [Presentation] ヒト満期胎盤絨毛における細胞性栄養膜細胞層の3次元構造解析2021

    • Author(s)
      櫻井 孝信, 菅 潮里, 島田 春貴, 高橋 宏典, 大口 昭英, 瀧澤 俊広
    • Organizer
      第29回日本胎盤学会学術集会
    • Data Source
      KAKENHI-PROJECT-20K09611
  • [Presentation] Non-coding RNAs in extravillous trophoblast cells. (Symposium 4: Prediction & Prevention of PE)2021

    • Author(s)
      Toshihiro Takizawa, Manabu Ogoyama, Hironori Takahashi, Akihide Ohkuchi
    • Organizer
      The 22nd World Congress of International Society for the Study of Hypertension in Pregnancy, ISSHP 2021
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K09611
  • [Presentation] Long non-coding RNA H19由来のmiR-675-5pは転写調節因子GATA2を介して絨毛外栄養膜細胞の浸潤を促進する2020

    • Author(s)
      小古山 学、大口 昭英、高橋 宏典、松原 茂樹、瀧澤 俊広
    • Organizer
      第72回日本産科婦人科学会学術講演会
    • Data Source
      KAKENHI-PROJECT-20K09611
  • [Presentation] ヒト胎盤高発現lncRNAの妊娠高血圧腎症胎盤における発現解析2020

    • Author(s)
      小古山 学、王 じゅん曉、趙 東威、高橋 宏典、松原 茂樹、大口 昭英、瀧澤 俊広
    • Organizer
      第28回日本胎盤学会学術集会
    • Data Source
      KAKENHI-PROJECT-20K09611
  • [Presentation] miR-675-5pは複数のmatrix metalloproteinaseの発現を上昇させ絨毛外栄養膜細胞の浸潤を促進する2020

    • Author(s)
      小古山 学、大口 昭英、高橋 宏典、松原 茂樹、瀧澤 俊広
    • Organizer
      第35回日本生殖免疫学会総会・学術集会
    • Data Source
      KAKENHI-PROJECT-20K09611
  • [Presentation] 胎盤絨毛栄養膜細胞のmiRNA生合成酵素DROSHAは従来にない遺伝子発現を調節 する機能を有している2020

    • Author(s)
      瀧澤 俊広、高橋 宏典、小古山 学、大口 昭英、竹下 俊行、松原 茂樹
    • Organizer
      第72回日本産科婦人科学会学術講演会
    • Data Source
      KAKENHI-PROJECT-20K09611
  • [Presentation] Long non-coding RNA H19の栄養膜細胞浸潤メカニズムへの関与2019

    • Author(s)
      小古山 学、大口 昭英、高橋 宏典、松原 茂樹、瀧澤 俊広
    • Organizer
      第71回日本産科婦人科学会学術講演会
    • Data Source
      KAKENHI-PROJECT-17K11256
  • [Presentation] miR-675-5p generated from lncRNA H19 accelerates the invasive ability of extravillous trophoblasts2019

    • Author(s)
      Ogoyama Manabu, Ohkuchi Akihide, Takahashi Hironori, Matsubara Shigeki, Takizawa Toshihiro
    • Organizer
      第14回国際生殖免疫学会/ 第35回日本生殖免疫学会総会学術集会
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K11256
  • [Presentation] ヒト初期胎盤の合胞体性栄養膜細胞はmiRNAを生合成している2019

    • Author(s)
      瀧澤 俊広、高橋 宏典、小古山 学、大口 昭英、竹下 俊行、松原 茂樹
    • Organizer
      第71回日本産科婦人科学会学術講演会
    • Data Source
      KAKENHI-PROJECT-17K11256
  • [Presentation] 妊娠高血圧腎症のハイリスクとしての妊娠初期のtemporary hypertension2019

    • Author(s)
      平嶋 周子, 大口 昭英, 高橋 佳代, 鈴木 寛正, 小古山 学, 永山 志穂, 高橋 宏典, 薄井 里英, 桑田 知之, 松原 茂樹
    • Organizer
      日本妊娠高血圧学会
    • Data Source
      KAKENHI-PROJECT-17K11247
  • [Presentation] LncRNA H19由来のmiR-675-5pは栄養膜細胞の浸潤に関与している2019

    • Author(s)
      小古山 学、大口 昭英、高橋 宏典、松原 茂樹、瀧澤 俊広
    • Organizer
      第27回日本胎盤学会学術集会
    • Data Source
      KAKENHI-PROJECT-17K11256
  • [Presentation] Immunohistochemical analysis of miRNA processing molecules in the syncytiotrophoblast of the human first trimester placenta2018

    • Author(s)
      Toshihiro Takizawa、Chaw Kyi-Tha-Thu、Hironori Takahashi、Manabu Ogoyama、Akihide Ohkuchi、Toshiyuki Takeshita、Shigeki Matsubara
    • Organizer
      IFPA(International Federation of Placenta Associations)2018、第26回日本胎盤学会学術集会
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K11256
  • [Presentation] WNT10BによるCD44を介した絨毛外栄養膜の浸潤促進2018

    • Author(s)
      高橋宏典、小古山学、大口昭英、瀧澤俊広、松原茂樹
    • Organizer
      第70回日本産科婦人科学会学術講演会
    • Data Source
      KAKENHI-PROJECT-16K11103
  • [Presentation] 産褥期にループス腎炎と診断された早発型妊娠高血圧腎症 血清sFlt-1、PIGF値測定の有用性について2018

    • Author(s)
      平嶋周子, 大口昭英, 小古山学, 坂井典子, 薄井里英, 松原茂樹
    • Organizer
      第 54 回日本周産期・新生児医学会学術集会
    • Data Source
      KAKENHI-PROJECT-17K11256
  • [Presentation] 妊娠高血圧腎症の発症予知と予防:Prognosis Asiaの結果を踏まえて2018

    • Author(s)
      大口昭英
    • Organizer
      第39回日本妊娠高血圧学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K11256
  • [Presentation] WNT10BによるCD44を介した絨毛外栄養膜の浸潤促進2018

    • Author(s)
      高橋宏典、小古山学、石田洋一、大口昭英、瀧澤俊広、松原茂樹
    • Organizer
      第70回日本産科婦人科学会学術講演会
    • Data Source
      KAKENHI-PROJECT-17K11256
  • [Presentation] 妊娠高血圧腎症,HELLP症候群の発症週数別sFlt-1,PlGF,及びsFlt-1/PlGFの比較2018

    • Author(s)
      鈴木寛正, 平嶋周子, 永山志穂, 小古山学, 馬場洋介, 高橋宏典, 高橋佳代, 薄井里英, 大口昭英, 松原茂樹
    • Organizer
      第70回日本産科婦人科学会学術講演会
    • Data Source
      KAKENHI-PROJECT-17K11256
  • [Presentation] WNT10Bによる絨毛外栄養膜の浸潤促進2018

    • Author(s)
      高橋宏典、小古山学、永山志穂、大口昭英、瀧澤俊広、松原茂樹
    • Organizer
      第33回日本生殖免疫学会総会・学術集会
    • Data Source
      KAKENHI-PROJECT-17K11256
  • [Presentation] ヒト胎盤合胞体栄養膜細胞はmiRNA合成酵素のDICER1を発現している2018

    • Author(s)
      瀧澤俊広、高橋宏典、Chaw Kyi-Tha-Thu、小古山学、大口昭英、竹下俊行、松原茂樹
    • Organizer
      第70回日本産科婦人科学会学術講演会
    • Data Source
      KAKENHI-PROJECT-17K11256
  • [Presentation] 卵胞期から黄体期にかけての母体末梢血NK細胞の変動2017

    • Author(s)
      石田 洋一、大口 昭英、鈴木 達也、高橋 宏典、瀧澤 俊広、松原 茂樹
    • Organizer
      第32回日本生殖免疫学会総会・学術集会
    • Data Source
      KAKENHI-PROJECT-17K11256
  • [Presentation] シリアルブロックフェイス走査電顕を用いたヒト満期胎盤絨毛の構造解析2017

    • Author(s)
      島田 春貴、山口 祐樹、瀧澤 敬美、高橋 宏典、大口 昭英、竹下 俊行、松原 茂樹、瀧澤 俊広
    • Organizer
      第25回日本胎盤学会学術集会
    • Data Source
      KAKENHI-PROJECT-17K11256
  • [Presentation] DICER1はヒト満期胎盤の合胞体栄養膜細胞に発現している2017

    • Author(s)
      瀧澤 俊広、高橋 宏典、Kyi-Tha-Thu Chaw、小古山 学、大口 昭英、竹下 俊行、松原 茂樹
    • Organizer
      第32回日本生殖免疫学会総会・学術集会
    • Data Source
      KAKENHI-PROJECT-17K11256
  • [Presentation] Advanced Glycation End Products (AGE)はヒトおよびマウス胎盤でinterleukin-1b産生を調節する2017

    • Author(s)
      1)白砂孔明,妹尾琴実,高橋宏典,大口昭英,鈴木寛正,岩田尚孝,桑山岳人
    • Organizer
      第25回日本胎盤学会
    • Data Source
      KAKENHI-PROJECT-26462498
  • [Presentation] Change in microRNA expression in preeclamptic maternal blood : Sixty such microRNA detected by microarray analysis (3D-Gene chip) with global normalization2017

    • Author(s)
      Hironori Takahashi, Manabu Ogoyama, Shiho Nagayama, Yoichi Ishida, Hirotada Suzuki, Yosuke Baba, Tomoyuki Kuwata, Rie Usui, Toshihiro Takizawa, Akihide Ohkuchi, Shigeki Matsubara
    • Organizer
      第69回日本産科婦人科学会学術講演会
    • Data Source
      KAKENHI-PROJECT-17K11256
  • [Presentation] 妊娠高血圧腎症の分子基盤(シンポジウム10「周産期・新生児医学と腎臓病」)2017

    • Author(s)
      大口 昭英、鈴木 寛正、瀧澤 俊広、白砂 孔明、松原 茂樹
    • Organizer
      第60回日本腎臓学会学術講演会
    • Data Source
      KAKENHI-PROJECT-17K11256
  • [Presentation] ヒト栄養膜細胞の絨毛外栄養膜細胞への分化においてDLK1-DIO3領域のRNA発現は低下する2017

    • Author(s)
      瀧澤 俊広、Banyar T. Naing、高橋 宏典、桑田 知之、大口昭英、竹下 俊行、松原 茂樹
    • Organizer
      第69回日本産科婦人科学会学術講演会
    • Data Source
      KAKENHI-PROJECT-17K11256
  • [Presentation] 妊娠初期流産における末梢血および脱落膜natural killer細胞のmicroRNA発現プロファイル解析2017

    • Author(s)
      小古山 学、大口 昭英、島 友子、齋藤 滋、瀧澤 俊広
    • Organizer
      第32回日本生殖免疫学会総会・学術集会
    • Data Source
      KAKENHI-PROJECT-17K11256
  • [Presentation] Change in microRNA expression in preeclamptic maternal blood: Sixty microRNA detected by microarray analysis (3D-Gene chip) with global normalization2017

    • Author(s)
      Hironori Takahashi, Manabu Ogoyama, Shiho Nagayama, Yoichi Ishida, Yosuke Baba, Tomoyuki Kuwata, Rie Usui, Toshihiro Takizawa, Akihide Ohkuchi, Shigeki Matsubara
    • Organizer
      第69回日本産科婦人科学会学術講演会
    • Place of Presentation
      広島グリーンアリーナ(広島市)
    • Year and Date
      2017-04-15
    • Data Source
      KAKENHI-PROJECT-16K11103
  • [Presentation] 妊娠初期の脱落膜NK細胞は胎盤特異的microRNAを取り込んでいる2017

    • Author(s)
      小古山 学、大口 昭英、島 友子、齋藤 滋、瀧澤 俊広
    • Organizer
      第25回日本胎盤学会学術集会
    • Data Source
      KAKENHI-PROJECT-17K11256
  • [Presentation] 糖尿病性慢性腎不全妊婦における透析中のsoluble fms-like tyrosine kinase (sFlt)-1変化2016

    • Author(s)
      佐野実穂,森澤宏行,大口昭英,高橋宏典,平嶋周子,薄井里英,安藤明彦,森下義幸,松原茂樹
    • Organizer
      第26回腎と妊娠研究会
    • Place of Presentation
      千里ライフサイエンスセンター
    • Year and Date
      2016-03-05
    • Data Source
      KAKENHI-PROJECT-24592482
  • [Presentation] White coat hypertension in pregnancy: high incidence rates of gestational hypertension and preeclampsia2016

    • Author(s)
      Ohkuchi A, Takahashi K, Hirashima C, Suzuki H, Nagayama S, Takahashi H, Eguchi K, Matsubara S.
    • Organizer
      The XX World Congress of ISSHP
    • Place of Presentation
      the Maksoud Plaza Hotel (Sao Paulo, Brazil)
    • Year and Date
      2016-10-23
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-24592482
  • [Presentation] 妊娠高血圧腎症妊婦における赤血球膜脂肪酸のω9一価不飽和酸重量比率と血清PlGF濃度との正相関2016

    • Author(s)
      小林真実,大口昭英,平嶋周子,高橋佳代,鈴木寛正,森澤宏行,松原茂樹
    • Organizer
      第26回腎と妊娠研究会
    • Place of Presentation
      千里ライフサイエンスセンター
    • Year and Date
      2016-03-05
    • Data Source
      KAKENHI-PROJECT-24592482
  • [Presentation] 糖尿病家族歴と妊娠糖尿病、妊娠高血圧あるいは妊娠高血圧腎症発症との関係2015

    • Author(s)
      永山志穂、高橋佳代、大口昭英、平嶋周子、猿山美幸、鈴木寛正、松原茂樹、鈴木光明
    • Organizer
      第67回日本産科婦人科学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2015-04-10
    • Data Source
      KAKENHI-PROJECT-24592482
  • [Presentation] 妊娠初期栄養膜細胞における a Disintegrin and Metalloproteinase(ADAM)ファミ リーの発現:絨毛外栄養膜細胞浸潤への ADAM 関与可能性2015

    • Author(s)
      高橋宏典、松原茂樹、大口昭英、薄井里英、桑田知之、馬場洋介、鈴木寛正、瀧澤俊広、鈴木光明
    • Organizer
      第67回日本産科婦人科学会学術講演会
    • Place of Presentation
      パシフィコ横浜/神奈川
    • Year and Date
      2015-04-10
    • Data Source
      KAKENHI-PROJECT-24390383
  • [Presentation] 家庭血圧測定における変曲点の在胎週数、血圧レベル、及び、その後2週間の血圧増加速度を用いた妊娠高血圧腎症並びに妊娠高血圧の発症予知2015

    • Author(s)
      猿山美幸、大口昭英、高橋佳代、大丸貴子、平嶋周子、鈴木寛正、松原茂樹、鈴木光明
    • Organizer
      第67回日本産科婦人科学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2015-04-12
    • Data Source
      KAKENHI-PROJECT-24592482
  • [Presentation] 妊娠高血圧腎症における赤血球膜脂肪酸組成中の飽和、一価不飽和、ω-3脂肪酸比率2015

    • Author(s)
      小林真実、廣瀬典子、大口昭英、大丸貴子、松原茂樹、鈴木光明
    • Organizer
      第67回日本産科婦人科学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2015-04-12
    • Data Source
      KAKENHI-PROJECT-24592482
  • [Presentation] 妊娠初期栄養膜細胞におけるa Disintegrin and Metalloproteinase(ADAM)ファミリーの発現:絨毛外栄養膜細胞浸潤へのADAM関与可能性2015

    • Author(s)
      高橋宏典、松原茂樹、大口昭英、薄井里英、桑田知之、馬場洋介、鈴木寛正、瀧澤俊広、鈴木光明
    • Organizer
      第67回日本産科婦人科学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2015-04-10
    • Data Source
      KAKENHI-PROJECT-24592482
  • [Presentation] 蛋白/クレアチニン比と24時間尿中蛋白尿との関係の再検討 正常血圧妊婦を中心に2015

    • Author(s)
      馬場洋介,松原茂樹,大口昭英,桑田知之,薄井里英,高橋宏典,鈴木寛正,廣瀬典子,永山志穂,小古山 学,猿山美幸
    • Organizer
      第51回日本周産期・新生児医学会学術集会
    • Place of Presentation
      ヒルトン福岡シーホーク
    • Year and Date
      2015-07-11
    • Data Source
      KAKENHI-PROJECT-24592482
  • [Presentation] 妊娠期間中の母体末梢血NK細胞におけるmiRNA-mRNAの変動解析2015

    • Author(s)
      石田洋一,趙東威,大口昭英,桑田知之,松原茂樹,斎藤滋,瀧澤俊広
    • Organizer
      第30回日本生殖免疫学会総会・学術集会
    • Place of Presentation
      くまもと県民交流館パレア/熊本県
    • Year and Date
      2015-11-22
    • Data Source
      KAKENHI-PROJECT-24390383
  • [Presentation] 糖尿病家族歴、高血圧家族歴の妊娠糖尿病、妊娠高血圧、及び、妊娠高血圧腎症発症に及ぼす影響:多変量解析2015

    • Author(s)
      永山志穂、高橋佳代、大口昭英、平嶋周子、猿山美幸、鈴木寛正、松原茂樹
    • Organizer
      第39回日本産婦人科栄養・代謝研究会
    • Place of Presentation
      東京医科歯科大学 MDタワー
    • Year and Date
      2015-08-22
    • Data Source
      KAKENHI-PROJECT-24592482
  • [Presentation] 妊娠中期、後期前半の胎盤成長因子濃度とその後のSGA児及びsmall placenta発生との関連2015

    • Author(s)
      平嶋周子、大口昭英、高橋佳代、鈴木寛正、松原茂樹、鈴木光明
    • Organizer
      第67回日本産科婦人科学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2015-04-10
    • Data Source
      KAKENHI-PROJECT-24592482
  • [Presentation] sFlt-1が異常高値を示した急性妊娠脂肪肝 症例報告2015

    • Author(s)
      鈴木寛正,大口昭英,平嶋周子,高橋佳代,森澤宏行,永山志穂,高橋宏典,馬場洋介,桑田知之,薄井里英,渡辺 尚,松原茂樹
    • Organizer
      第51回日本周産期・新生児医学会学術集会
    • Place of Presentation
      ヒルトン福岡シーホーク
    • Year and Date
      2015-07-11
    • Data Source
      KAKENHI-PROJECT-24592482
  • [Presentation] 妊娠中期の血清galectin-1低値と、妊娠高血圧腎症及び妊娠高血圧の発症リスク2015

    • Author(s)
      鈴木寛正、平嶋周子、大口昭英、高橋佳代、永山志穂、高橋宏典、猿山美幸、薄井里英、松原茂樹、鈴木光明
    • Organizer
      第67回日本産科婦人科学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2015-04-12
    • Data Source
      KAKENHI-PROJECT-24592482
  • [Presentation] 妊娠高血圧症候群既往歴は、血圧高値と子宮動脈血流速度異常とは独立した妊娠高血圧腎症の危険因子である2014

    • Author(s)
      小林真実、高橋佳代、大口昭英、鈴木寛正、有賀治子、廣瀬典子、平嶋周子、松原茂樹、鈴木光明
    • Organizer
      第66回日本産婦人科学会総会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2014-04-19
    • Data Source
      KAKENHI-PROJECT-24592482
  • [Presentation] CD44を介した絨毛外栄養膜細胞の浸潤調節機構の解明2014

    • Author(s)
      高橋宏典, 弓削主哉, 松原茂樹, 大口昭英, 桑田知之, 薄井里英, 松本久宣, 佐藤幸保, 藤原浩, 岡本愛光, 瀧澤俊広, 鈴木光明
    • Organizer
      第66回日本産科婦人科学会学術講演会
    • Place of Presentation
      東京国際フォーラム (東京)
    • Year and Date
      2014-04-18
    • Data Source
      KAKENHI-PROJECT-24390383
  • [Presentation] ヒト胎盤特異的マイクロRNA はエクソソームを介して母体免疫細胞の遺伝子発現を修飾している2014

    • Author(s)
      神戸沙織, 弓削主哉, 石田洋一, 大口昭英, 松原茂樹, 鈴木光明, 齋藤滋, 瀧澤俊広, 竹下俊行
    • Organizer
      第66回日本産科婦人科学会学術講演会
    • Place of Presentation
      東京国際フォーラム (東京)
    • Year and Date
      2014-04-18
    • Data Source
      KAKENHI-PROJECT-24390383
  • [Presentation] 妊娠高血圧症候群と血管新生関連因子2014

    • Author(s)
      大口昭英,鈴木寛正,平嶋周子,高橋佳代,松原茂樹,鈴木光明
    • Organizer
      第29回日本生殖免疫学会総会・学術集会
    • Place of Presentation
      伊藤国際学術研究センター
    • Year and Date
      2014-12-12
    • Data Source
      KAKENHI-PROJECT-24592482
  • [Presentation] 妊娠中期、後期前半のsFlt-1/PIGF比、及び、soluble endoglinによる妊娠高血圧腎症発症リスク評価2014

    • Author(s)
      平嶋周子, 大口昭英, 高橋佳代, 松原茂樹, 鈴木光明
    • Organizer
      第35回日本妊娠高血圧学会
    • Place of Presentation
      京王プラザ
    • Year and Date
      2014-09-20
    • Data Source
      KAKENHI-PROJECT-24592482
  • [Presentation] Prediction of preeclampsia using angiogenesis-reltaed factors or home blood pressure monitoring.2014

    • Author(s)
      Ohkuchi A, HIrashima C, Saruyama M, Takahashi K, Ohmaru T, Suzuki H, Matsubara S, Suzuki M.
    • Organizer
      Workshop on the 46th International Congress on Pathophysiology of Pregnancy.
    • Place of Presentation
      Keio Plaza Hotel
    • Year and Date
      2014-09-19
    • Data Source
      KAKENHI-PROJECT-24592482
  • [Presentation] The existence of inflection point in home blood pressure monitoring at earlier gestational weeks in preeclampsia and gestational hypertension.2014

    • Author(s)
      Saruyama M, Ohkuchi A, Takahashi K, Ohmaru T, Hirashima C, Suzuki H, Matsubara S, Suzuki M.
    • Organizer
      46th International Congress on Pathophysiology of Pregnancy.
    • Place of Presentation
      Keio Plaza Hotel
    • Year and Date
      2014-09-19
    • Data Source
      KAKENHI-PROJECT-24592482
  • [Presentation] Involvement of microRNAs in pathophysiology of preeclampsia2014

    • Author(s)
      Toshihiro Takizawa, Akihide Ohkuchi, Shigeru Saito, Toshiyuki Takeshita
    • Organizer
      第46回国際妊娠病態生理学会
    • Place of Presentation
      京王プラザホテル (東京)
    • Year and Date
      2014-09-18
    • Data Source
      KAKENHI-PROJECT-24390383
  • [Presentation] 栄養膜細胞におけるC19MCプロモーター領域のメチル化解析2014

    • Author(s)
      高橋宏典, 大口昭英, 桑田知之, 薄井里英, 菊池邦生, 松原茂樹, 鈴木光明, 竹下俊行, 瀧澤俊広
    • Organizer
      第22回日本胎盤学会学術集会
    • Place of Presentation
      京都大学芝蘭会館 (京都)
    • Year and Date
      2014-10-03
    • Data Source
      KAKENHI-PROJECT-24390383
  • [Presentation] 妊娠36週未満発症の妊娠高血圧腎症の発症予知法の改良-血中血管新生関連因子の正常域から疾患発症閾値への展開-2013

    • Author(s)
      大口昭英
    • Organizer
      第65回日本産科婦人科学会学術講演会
    • Place of Presentation
      ロイトン札幌、ホテルさっぽろ芸文館(旧北海道厚生年金会館)、札幌プリンスホテル
    • Data Source
      KAKENHI-PROJECT-24592482
  • [Presentation] 絨毛外栄養膜細胞の内因性miR-520cの発現抑制がCD44を介した絨毛外栄養膜細胞の浸潤を促進している2013

    • Author(s)
      高橋宏典、弓削主哉、瀧澤敬美、松原茂樹、大口昭英、桑田知之、薄井里英、松本久宜、佐藤幸保、藤原浩、岡本愛光、鈴木光明、瀧澤俊広
    • Organizer
      第28回日本生殖免疫学会総会・学術集会
    • Place of Presentation
      兵庫医科大学 (西宮市、兵庫)
    • Data Source
      KAKENHI-PROJECT-24390383
  • [Presentation] 妊娠高血圧症候群の病態におけるmicroRNAの関与2013

    • Author(s)
      瀧澤俊広、吉武洋、竹下俊行、大口昭英、齋藤滋
    • Organizer
      第34回日本妊娠高血圧学会学術講演会
    • Place of Presentation
      富山国際会議場 (富山市、富山)
    • Data Source
      KAKENHI-PROJECT-24390383
  • [Presentation] CD44による絨毛外栄養膜細胞の浸潤機構:WNTシグナルによる促進2013

    • Author(s)
      高橋宏典、吉武洋、松原茂樹、大口昭英、桑田知之、薄井里英、岡本愛光、鈴木光明、瀧澤俊広
    • Organizer
      第21回日本胎盤学会学術集会
    • Place of Presentation
      ウインクあいち (名古屋市、愛知)
    • Data Source
      KAKENHI-PROJECT-24390383
  • [Presentation] エクソソームは胎盤特異的マイクロRNAを妊婦末梢血免疫細胞に移行する2013

    • Author(s)
      神戸沙織、石田洋一、吉武洋、弓削主哉、瀧澤敬美、大口昭英、齋藤滋、竹下俊行、瀧澤俊広
    • Organizer
      第28回日本生殖免疫学会総会・学術集会
    • Place of Presentation
      兵庫医科大学 (西宮市、兵庫)
    • Data Source
      KAKENHI-PROJECT-24390383
  • [Presentation] 塩酸リトドリンの副反応とその対応について2013

    • Author(s)
      大口昭英、堀江健司、鈴木寛正、桑田知之、薄井里英、松原茂樹、鈴木光明
    • Organizer
      第7回日本早産予防研究会学術集会
    • Place of Presentation
      日本医科大学附属武蔵小杉病院
    • Data Source
      KAKENHI-PROJECT-24592482
  • [Presentation] MicroRNAを介した絨毛栄養膜細胞による絨毛外栄養膜細胞の浸潤制御2013

    • Author(s)
      高橋宏典、菊池邦生、大口昭英、松原茂樹、桑田知之、薄井里英、松本久宣、佐藤幸保、藤原浩、岡本愛光、瀧澤俊広、鈴木光明
    • Organizer
      第65回日本産科婦人科学会学術講演会
    • Place of Presentation
      ロイトン札幌 (札幌市、北海道)
    • Data Source
      KAKENHI-PROJECT-24390383
  • [Presentation] 妊婦末梢血natural killer細胞における胎盤特異的マイクロRNA標的遺伝子候補の検索2013

    • Author(s)
      神戸沙織、吉武洋、石田洋一、大口昭英、松原茂樹、鈴木光明、齋藤滋、瀧澤俊広、竹下俊行
    • Organizer
      第65回日本産科婦人科学会学術講演会
    • Place of Presentation
      札幌プリンスホテル (札幌市、北海道)
    • Data Source
      KAKENHI-PROJECT-24390383
  • [Presentation] エクソソームを介した胎盤特異的マイクロRNAによる胎盤・免疫細胞間情報伝達機構2013

    • Author(s)
      神戸沙織、吉武洋、石田洋一、瀧澤敬美、大口昭英、松原茂樹、鈴木光明、竹下俊行、齋藤滋、瀧澤俊広
    • Organizer
      第21回日本胎盤学会学術集会
    • Place of Presentation
      ウインクあいち (名古屋市、愛知)
    • Data Source
      KAKENHI-PROJECT-24390383
  • [Presentation] 観察研究の進め方2013

    • Author(s)
      大口昭英
    • Organizer
      日本消化器内視鏡学会茨城県部会第25回研究会
    • Place of Presentation
      オークラフロンティア ホテルつくばアネックス
    • Invited
    • Data Source
      KAKENHI-PROJECT-24592482
  • [Presentation] THE ADDITIVE EFFECT OF PLASMA LEVELS OF SFLT-1/PLGF RATIO FOLLOWING THE RISK CLASSIFICATION USING BOTH BLOOD PRESSURE LEVELS AND UTERINE ARTERY BLOOD FLOW IMPEDANCE IN THE SECOND TRIMESTER ON THE LATER OCCURRENCE OF PREECLAMPSIA2012

    • Author(s)
      Akihide Ohkuchi, Chikako Hirashima, Kayo Takahashi, Sigeki Matsubara, Mitsuaki Suzuki
    • Organizer
      XVIII International Society for the Study of Hypertension in Pregnancy (ISSHP) World Congress
    • Place of Presentation
      Geneva
    • Data Source
      KAKENHI-PROJECT-24592482
  • [Presentation] microRNA (miR 210 及びmiR 518)の標的遺伝子産物HSD17B1蛋白質の血漿レベル及び母体因子を用いた妊娠高血圧腎症の発症予知2012

    • Author(s)
      大口 昭英
    • Organizer
      第64回日本産科婦人科学会学術講演会
    • Place of Presentation
      神戸ポートピアホテル・神戸国際展示場(兵庫県)
    • Year and Date
      2012-04-13
    • Data Source
      KAKENHI-PROJECT-24390383
  • [Presentation] The preceding features before onset of gestational hypertension and preeclampsia in home blood pressure monitoring: the existence of the inflection point and the rapid increased speed of blood pressure2012

    • Author(s)
      Takako Ohmaru, Akinori Miki, Kayo Takahashi, Akihide Ohkuchi, Atsuo Itakura, Shigeki Matsubara, Mitsuaki Suzuki
    • Organizer
      XVIII International Society for the Study of Hypertension in Pregnancy (ISSHP) World Congress
    • Place of Presentation
      Geneva
    • Data Source
      KAKENHI-PROJECT-24592482
  • [Presentation] The screening with the combination of notch depth index of the uterine artery flow velocity waveforms and prehypertension hypertension at second trimester improved the sensitivity for the predicton of preeclampsia2007

    • Author(s)
      Ohkuchi A, et. al.
    • Organizer
      The 59th congress of Japan Society of Obstetrics and Gynecology
    • Place of Presentation
      Kyoto
    • Year and Date
      2007-04-16
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18591809
  • [Presentation] 妊娠中期子宮動脈血流速度波形notch depth index上昇あるいは妊娠中期高血圧前症/高血圧を用いたスリーニングは妊娠高血圧腎症発症予知の感度を上昇させる2007

    • Author(s)
      大口 昭英, 他
    • Organizer
      第59回日本産科婦人科学会学術講演会
    • Place of Presentation
      京都
    • Year and Date
      2007-04-16
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18591809
  • [Presentation] 妊娠中の自由行動下血圧指標はSmall for Gestational Ageに関連している.

    • Author(s)
      江口和男, 大丸貴子, 大口昭英, 平嶋周子, 高橋佳代, 鈴木寛正, 苅尾七臣, 松原茂樹, 鈴木光明
    • Organizer
      第37回日本高血圧学会総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-10-17 – 2014-10-19
    • Data Source
      KAKENHI-PROJECT-24592482
  • [Presentation] Decreased circulating levels of galectin-1 in the second trimester as an independent risk factor for not only preeclampsia but also gestational hypertension.

    • Author(s)
      Ohkuchi A, Hirashima C, Nagayama S, Suzuki H, Takahashi K, Matsubara S, Suzuki M.
    • Organizer
      XIX International society for the study of hypertension in pregnancy (ISSHP) World Congress
    • Place of Presentation
      Hilton &#8211; New Orleans Riverside
    • Year and Date
      2014-10-26 – 2014-10-29
    • Data Source
      KAKENHI-PROJECT-24592482
  • 1.  TAKIZAWA Toshihiro (90271220)
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  • 2.  Takahashi Hironori (80544303)
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  • 5.  MATSUBARA Shigeki (20209597)
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  • 11.  WATANABE Takashi (90265265)
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  • 12.  石田 洋一 (70772143)
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  • 13.  大倉 定之 (10731036)
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  • 14.  河野 由美 (50243390)
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  • 17.  永山 志穂 (80741694)
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  • 18.  野口 隼矢 (30879698)
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  • 19.  野平 知良 (30276935)
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  • 20.  成瀬 勝彦 (70453165)
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  • 24.  EGUCHI Kazuo
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  • 25.  谷口 俊一郎
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  • 26.  斎藤 滋
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  • 27.  岩田 尚孝
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  • 28.  桑山 岳人
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