HAYASHI Yoshio 林良雄

Researcher Number	10322562
Other IDs
Affiliation (Current)	2025: 東京薬科大学, 生命科学部, 教授
Affiliation (based on the past Project Information) *help	2023 – 2024: 東京薬科大学, 生命科学部, 教授 2007 – 2022: Tokyo University of Pharmacy and Life Science, School of Pharmacy, Professor 2013: 東京薬科大学, 薬学部 2001 – 2006: 京都薬科大学, 薬学部, 助教授 2000: 京都薬科大学, 薬学部, 講師
Review Section/Research Field	Principal Investigator Drug development chemistry / Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related / Science and Engineering / Sections That Are Subject to Joint Review: Basic Section47010:Pharmaceutical chemistry and drug development sciences-related , Basic Section47050:Environmental and natural pharmaceutical resources-related / Basic Section 47050:Environmental and natural pharmaceutical resources-related / Drug development chemistry / 医薬分子機能学 / Science and Engineering Except Principal Investigator Pathobiological dentistry/Dental radiology / Drug development chemistry / 医薬分子機能学 / Biological Sciences
Keywords	Principal Investigator 薬学 / 創薬化学 / 抗がん剤 / ジケトピペラジン / フェニラヒスチン / 生体分子 / 創薬 / 有機化学 / ペプチド化学 / ケミカルバイオロジー … More / プロドラッグ / 有機合成化学 / 血管内皮細胞障害 / 癌 / ペプチドー薬物架橋体 / マイオスタチン / ペプチド / プロテアーゼ阻害剤 / チューブリン / 化学薬剤学 / 分子認識 / 合成化学 / 抗ウイルス剤 / ペプチド－薬物架橋体 / 固相ジスルフィドライゲーション / 有機合成 / ジスルフィド結合 / ペプチドー薬物複合体 / 中分子ペプチド / 固相ジスルフィドライゲーション / γ―チューブリン / 水溶性プロドラック / プリナブリン / γ-チューブリン / αヘリックス / ペプチド誘導体 / 構造活性相関 / 受容体選択性 / 阻害剤 / アゴニスト / 構造活性相関研究 / ニューロメジンU / Lactic polymer / Oligo arginine / Taxiods / Cancer / Organic Chemistry / Prodrug / Pharmaceutical Science / Chemical Pharmaceutics / 化学的メカニズム / 水溶性 / 乳酸ポリマー / オリゴアルギニン / タキソイド / Monodehydrodiketopiperazine / Anti-microtubule Agent / Racemization / Convenient Synthetic Method / Phenylahistin / Anticancer Agent / Bio-function-Mimicking Molecular Platform / Diketopiperazine / モノデヒドロジケトピペラジン / 抗チューブリン剤 / ラセミ化 / 簡便合成法 / フェニルヒスチン / 生体機能発現分子プラットフォーム / molecular design / medicinal chemistry / molecular function / diketopiperazine derivatives / total synthesis / anti-cancer drug / inhibition of tubulin polymerization / phenylahistin / 抗ガン剤 / チューブリン阻害剤 / 抗癌剤 / 分子設計 / 分子機能 / ジケトピペラジン誘導体 / 全合成 / チューブリン重合阻害 / システインプロテアーゼ / 固相合成化学 / 感染症 / ビオチニル化試薬 / 重症急性呼吸器症候群 / 医薬品化学 / ペプチド創薬 / システインプロテーアゼ阻害剤 / 固相ジスルフィド縮合法 / システインプロテアーゼ阻害剤 / 遺伝子疾患治療薬 / リードスルー薬 / 難治性疾患 / ネガマイシン / 遺伝子読み飛ばし / ネガマシン / 筋ジストロフィー / 遺伝病 / 抗がん剤癌 / 化学プローブ / チューブリン作用薬 / 医薬品開発 … More Except Principal Investigator ドラッグデザイン / アスパラギン酸プロテアーゼ / セクレターゼ / アルツハイマー病 / 酵素阻害剤 / HTLV-1 protease / adult T-cell leukemia / plasmepsin / β-secretase / Alzheimer's disease / aspartic protease / enzyme inhibitors / 難病治療薬 / 分子認識 / マラリア / HIVプロテアーゼ / HTLV-1プロテアーゼ / 成人T細胞白血病 / プラスメプシン / β-セクレターゼ / Anti-HIV Activity / Enzyme Inhibitor / Peptide Synthesis / HIV Protease Inhibitor / Substrate Transition State / AIDS Therapeutics / Molecular Recognition / HIV Protease / ペプチド合成 / プロドラック / 酵素・阻害剤複合体 / プロドラッグ / 薬剤耐性 / 抗ウイルス薬 / ペプチドミメティック / エイズ治療薬 / HIVプロテアーゼ阻害剤 / 口腔癌 / 小線源治療 / 腫瘍微小環境 / 放射線治療 / 分子イメージング / アミロイド産生 / 老化 Less

Development of innovative drug discovery based on SARS-CoV-2 3CL protease inhibitor YH-53Principal Investigator
- Principal Investigator
  
  林良雄
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
  Basic Section 47050:Environmental and natural pharmaceutical resources-related
  Sections That Are Subject to Joint Review: Basic Section47010:Pharmaceutical chemistry and drug development sciences-related , Basic Section47050:Environmental and natural pharmaceutical resources-related
- Research Institution
  Tokyo University of Pharmacy and Life Science
Synthesis and Medicinal Chemical Development of Mid-Sized Peptide Conjugate Based on the Chemistry of Solid-Phase Disulfide LigationPrincipal Investigator
- Principal Investigator
  
  Hayashi Yoshio
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  Tokyo University of Pharmacy and Life Science
Development of a ganma-tubulin targeting diketopiperazine and its study on chemical biologyPrincipal Investigator
- Principal Investigator
  
  Hayashi Yoshio
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Drug development chemistry
- Research Institution
  Tokyo University of Pharmacy and Life Science
Development of myostatin inhibitory peptides for the treatment of muscle wasting disorderPrincipal Investigator
- Principal Investigator
  
  林良雄
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for JSPS Fellows
- Research Field
  
  Drug development chemistry
- Research Institution
  Tokyo University of Pharmacy and Life Science
Studies on molecular functions of mid-size peptides derived from living system and their basic research for practical drug discoveryPrincipal Investigator
- Principal Investigator
  
  Yoshio Hayashi
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Tokyo University of Pharmacy and Life Science
天然由来ジペプチド様物質ネガマイシンを戦略分子とする創薬基盤研究Principal Investigator
- Principal Investigator
  
  林良雄
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Science and Engineering
- Research Institution
  Tokyo University of Pharmacy and Life Science
Development of brachytherapy for early stage oral cancer using I-125 seeds
- Principal Investigator
  
  Miura Masahiko
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathobiological dentistry/Dental radiology
- Research Institution
  Tokyo Medical and Dental University
Integrated medicinal chemistry research of intractable diseases based on peptidic small moleculesPrincipal Investigator
- Principal Investigator
  
  HAYASHI Yoshio
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Tokyo University of Pharmacy and Life Science
Visualization of oral cancer microenvironment using molecular imaging and its application to radiotherapy
- Principal Investigator
  
  MIURA Masahiko
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathobiological dentistry/Dental radiology
- Research Institution
  Tokyo Medical and Dental University
Study on Medicinal Chemistry of Reversible Cysteine Protease Inhibitors for the Treatment of Infectious DiseasesPrincipal Investigator
- Principal Investigator
  
  HAYASHI Yoshio
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Drug development chemistry
- Research Institution
  Tokyo University of Pharmacy and Life Science
Study on Medicinal Chemistry, Chemical Biology and Chemical Pharmaceutics of Anticancer Drug Based on the Microtubule Targeting AgentsPrincipal Investigator
- Principal Investigator
  
  HAYASHI Yoshio
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Tokyo University of Pharmacy and Life Science
化学療法による遺伝病克服への挑戦:デュシェンヌ型筋ジストロフィーの治療薬の開発Principal Investigator
- Principal Investigator
  
  林良雄
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Drug development chemistry
- Research Institution
  Tokyo University of Pharmacy and Life Science
腫瘍選択的血管内皮細胞障害物質フェニラヒスチンを戦略分子とする分子創薬基盤研究Principal Investigator
- Principal Investigator
  
  林良雄
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  Tokyo University of Pharmacy and Life Science
  Kyoto Pharmaceutical University
腫瘍選択的血管内皮細胞障害物質フェニラヒスチンを戦略分子とする分子創薬基盤研究Principal Investigator
- Principal Investigator
  
  林良雄
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  Kyoto Pharmaceutical University
Chemical Pharmaceutics Oriented Research on Medicinal ChemistryPrincipal Investigator
- Principal Investigator
  
  HAYAHI Yoshio
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Tokyo University of Pharmacy and Life Science
  Kyoto Pharmaceutical University
Design and development of therapeutic drugs for intractable diseases based on molecular recognition of aspartic proteases
- Principal Investigator
  
  KISO Yoshiaki
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Kyoto Pharmaceutical University
Development of Anticancer and Antiviral Agents Based on Diketopiperazine as a Bio-function-Mimicking Molecular PlatformPrincipal Investigator
- Principal Investigator
  
  HAYASHI Yoshio
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Kyoto Pharmaceutical University
アルツハイマー病克服をめざしたアミロイドセクレターゼ制御分子のデザインと合成
- Principal Investigator
  
  KISO Yoshiaki
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto Pharmaceutical University
Design of resistance-surmountable HIV protease inhibitors based on molecular recognition analysis of mutant protease
- Principal Investigator
  
  KISO Yoshiaki
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  医薬分子機能学
- Research Institution
  Kyoto Pharmaceutical University
Molecular Function of Naturally Occurring Anti-microtubule Agent Phenylahistin (Determination of Structural Components Necessary for the Anti-microtubule activity t and Molecular Design for Drugs)Principal Investigator
- Principal Investigator
  
  HAYASHI Yoshio
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  医薬分子機能学
- Research Institution
  Kyoto Pharmaceutical University

[Book] 次世代ペプチド医薬創製2014
- Author(s)
  林　良雄、山本剛史、小岩井勇児
- Total Pages
  140
- Publisher
  メディカルドゥ
- Data Source
  KAKENHI-PROJECT-23390029
[Book] ファルマシア（最前線）2014
- Author(s)
  田口晃弘、濱田圭佑、林　良雄
- Total Pages
  50
- Publisher
  日本薬学会
- Data Source
  KAKENHI-PROJECT-23390029
[Book] ファルマシア2014
- Author(s)
  田口晃弘、濵田圭佑、林　良雄
- Total Pages
  5
- Publisher
  日本薬学会
- Data Source
  KAKENHI-PUBLICLY-26102740
[Book] 遺伝子医学MOOK21号「最新ペプチド合成技術とその創薬研究への応用」2012
- Author(s)
  山崎有理、林良雄
- Total Pages
  7
- Publisher
  株式会社メディカルドゥ
- Data Source
  KAKENHI-PROJECT-23390029
[Journal Article] Inactivation of myostatin by photooxygenation using functionalized D-peptides2023
- Author(s)
  Hideyuki Okamoto, Shuko Amber Murano, Kaoru Ikekawa, Masahiro Katsuyama, Sho Konno, Akihiro Taguchi, Kentaro Takayama, Atsuhiko Taniguchi, and Yoshio Hayashi
- Journal Title
  
  RSC Med Chem
  
  Volume: 14 Issue: 2 Pages: 386-392
- DOI
  10.1039/d2md00425a
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03356, KAKENHI-PROJECT-22KJ2793
[Journal Article] Establishment of One-Pot Disulfide-Driven Cyclic Peptide Synthesis with a 3-Nitro-2-pyridinesulfenate2023
- Author(s)
  Shida, H., Taguchi, A., Konno, S., Takayama, K., Taniguchi, A., Hayashi, Y.
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 71 Issue: 6 Pages: 435-440
- DOI
  10.1248/cpb.c23-00087
- ISSN
  0009-2363, 1347-5223
- Year and Date
  2023-06-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K27305
[Journal Article] Increasing Skeletal Muscle Mass in Mice by Non-Invasive Intramuscular Delivery of Myostatin Inhibitory Peptide by Iontophoresis2023
- Author(s)
  Kohki Michiue, Kentaro Takayama, Atsuhiko Taniguchi, Yoshio Hayashi, and Kentaro Kogure
- Journal Title
  
  Pharmaceuticals
  
  Volume: 16 Issue: 3 Pages: 397-397
- DOI
  10.3390/ph16030397
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03356
[Journal Article] Influence of novel readthrough agents on myelin protein zero translation in the peripheral nervous system2022
- Author(s)
  Yoshinori Otani, Akihiro Taguchi , Keisuke Hamada, Yoshio Hayashi, Yoshihide Yamaguchi, Hiroko Baba
- Journal Title
  
  Neuropharmacology
  
  Volume: 211 Pages: 109059-109059
- DOI
  10.1016/j.neuropharm.2022.109059
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06889, KAKENHI-PROJECT-19H03356
[Journal Article] Chemical Synthesis of an HIV-1 Protease Analog with Some Amides in a Polypeptide Main Chain Replaced by Disulfide Bonds2022
- Author(s)
  Yan Cui, Akihiro Taguchi, Hayate Shida, Sho Konno, Kentaro Takayama＊, Atsuhiko Taniguchi, and Yoshio Hayashi
- Journal Title
  
  Bull Chem Soc Jpn
  
  Volume: 95 Issue: 8 Pages: 1156-1162
- DOI
  10.1246/bcsj.20220103
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03356
[Journal Article] Development of Myostatin Inhibitory d-Peptides to Enhance the Potency, Increasing Skeletal Muscle Mass in Mice2022
- Author(s)
  Takayama Kentaro、Hitachi Keisuke、Okamoto Hideyuki、Saitoh Mariko、Odagiri Miki、Ohfusa Rina、Shimada Takahiro、Taguchi Akihiro、Taniguchi Atsuhiko、Tsuchida Kunihiro、Hayashi Yoshio
- Journal Title
  
  ACS Medicinal Chemistry Letters
  
  Volume: 13 Issue: 3 Pages: 492-498
- DOI
  10.1021/acsmedchemlett.1c00705
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07001, KAKENHI-PROJECT-19H03356, KAKENHI-PROJECT-19H03427, KAKENHI-PROJECT-20K07315
[Journal Article] Combination Therapy with Anamorelin and a Myostatin Inhibitor is Advantageous for Cancer Cachexia in a Mouse Model2022
- Author(s)
  Kako Hanada, Kunpei Fukasawa, Hiroki Hinata, Shu Imai, Kentaro Takayama, Hideyo Hirai, Rina Ohfusa, Yoshio Hayashi, Fumiko Itoh
- Journal Title
  
  Cancer Sci
  
  Volume: 113 Issue: 10 Pages: 3547-3557
- DOI
  10.1111/cas.15491
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03356, KAKENHI-PROJECT-20K07430
[Journal Article] Structural Revision of Natural Cyclic Depsipeptide MA026 Established by Total Synthesis and Biosynthetic Gene Cluster Analysis2021
- Author(s)
  Uchiyama Chihiro、Fukuda Akane、Mukaiyama Minagi、Nakazawa Yoshiki、Kuramochi Yuka、Muguruma Kyohei、Arimoto Mitsue、Ninomiya Akihiro、Kako Koichiro、Katsuyama Yohei、Konno Sho、Taguchi Akihiro、Takayama Kentaro、Taniguchi Atsuhiko、Nagumo Yoko、Usui Takeo、Hayashi Yoshio
- Journal Title
  
  Angewandte Chemie International Edition
  
  Volume: 60 Issue: 16 Pages: 8792-8797
- DOI
  10.1002/anie.202015193
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07001, KAKENHI-PROJECT-19H02893, KAKENHI-PROJECT-19H03356, KAKENHI-PROJECT-17K01942
[Journal Article] Synthesis and biological evaluation of a monocyclic Fc-binding antibody-recruiting molecule for cancer immunotherapy2021
- Author(s)
  Sasaki Koichi、Muguruma Kyohei、Osawa Rento、Fukuda Akane、Taniguchi Atsuhiko、Kishimura Akihiro、Hayashi Yoshio、Mori Takeshi、Katayama Yoshiki
- Journal Title
  
  RSC Medicinal Chemistry
  
  Volume: 12 Issue: 3 Pages: 406-409
- DOI
  10.1039/d0md00337a
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07001, KAKENHI-PROJECT-19H03356, KAKENHI-PROJECT-21K19055
[Journal Article] “On‐Resin” Disulfide Peptide Synthesis with Methyl 3‐Nitro‐2‐pyridinesulfenate2021
- Author(s)
  Kobayashi Kiyotaka、Taguchi Akihiro、Cui Yan、Shida Hayate、Muguruma Kyohei、Takayama Kentaro、Taniguchi Atsuhiko、Hayashi Yoshio
- Journal Title
  
  European Journal of Organic Chemistry
  
  Volume: 2021 Issue: 6 Pages: 956-963
- DOI
  10.1002/ejoc.202001517
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07001, KAKENHI-PROJECT-19K16324, KAKENHI-PROJECT-19H03356
[Journal Article] Development of functionalized peptides for efficient inhibition of myostatin by selective photooxygenation2021
- Author(s)
  Okamoto Hideyuki、Taniguchi Atsuhiko、Usami Shoya、Katsuyama Masahiro、Konno Sho、Taguchi Akihiro、Takayama Kentaro、Hayashi Yoshio
- Journal Title
  
  Organic & Biomolecular Chemistry
  
  Volume: 19 Issue: 1 Pages: 199-207
- DOI
  10.1039/d0ob02042g
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07001, KAKENHI-PROJECT-19H03356
[Journal Article] Proposal for the binding mode of the 23-mer inhibitory peptide to myostatin2021
- Author(s)
  Asari Tomo、Ikeyama Hiroaki、Taguchi Akihiro、Taniguchi Atsuhiko、Hayashi Yoshio、Takayama Kentaro
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 40 Pages: 116181-116181
- DOI
  10.1016/j.bmc.2021.116181
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07001, KAKENHI-PROJECT-19H03356
[Journal Article] Development of a high‐affinity antibody‐binding peptide for site‐specific modification.2021
- Author(s)
  Muguruma, K., Osawa, R., Fukuda, A., Ishikawa, N., Fujita, K., Taguchi, A., Takayama, K., Taniguchi, A., Ito, Y., Hayashi, Y.
- Journal Title
  
  ChemMedChem
  
  Volume: 16 Issue: 11 Pages: 1-9
- DOI
  10.1002/cmdc.202000977
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03356
[Journal Article] Disulfide-driven cyclic peptide synthesis of human endothelin-2 with a solid-supported Npys-Cl2020
- Author(s)
  Akihiro Taguchi, Kiyotaka Kobayashi, Yan Cui, Kentaro Takayama, Atsuhiko Taniguchi, Yoshio Hayashi
- Journal Title
  
  J. Org. Chem.
  
  Volume: 85 Issue: 3 Pages: 1495-1503
- DOI
  10.1021/acs.joc.9b02362
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03356, KAKENHI-PROJECT-19K07001
[Journal Article] Use of solid-supported 4-fluorophenyl 3-nitro-2-pyridinesulfenate in the construction of disulfide-linked hybrid molecules2020
- Author(s)
  Cui Yan、Taguchi Akihiro、Kobayashi Kiyotaka、Shida Hayate、Takayama Kentaro、Taniguchi Atsuhiko、Hayashi Yoshio
- Journal Title
  
  Organic & Biomolecular Chemistry
  
  Volume: 18 Issue: 36 Pages: 7094-7097
- DOI
  10.1039/d0ob01370f
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07001, KAKENHI-PROJECT-19K16324, KAKENHI-PROJECT-19H03356
[Journal Article] New negamycin-based potent readthrough derivative effective against TGA-type nonsense mutations2019
- Author(s)
  Keisuke Hamada, Noriko Omura, Akihiro Taguchi, Alireza Baradaran-Heravi, Masaya Kotake, Misaki Arai, Kentaro Takayama, Atsuhiko Taniguchi, Michel Roberge, Yoshio Hayashi
- Journal Title
  
  ACS Med. Chem. Lett.
  
  Volume: 10 Issue: 10 Pages: 1450-1456
- DOI
  10.1021/acsmedchemlett.9b00273
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03356
[Journal Article] Design and synthesis of potent myostatin inhibitory cyclic peptides2019
- Author(s)
  Rentier Cedric、Takayama Kentaro、Saitoh Mariko、Nakamura Akari、Ikeyama Hiroaki、Taguchi Akihiro、Taniguchi Atsuhiko、Hayashi Yoshio
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 27 Issue: 7 Pages: 1437-1443
- DOI
  10.1016/j.bmc.2019.02.019
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04658, KAKENHI-PROJECT-19K07001
[Journal Article] Synthesis and structure-activity relationship studies of IgG-binding peptides focused on the C-terminal histidine residue2019
- Author(s)
  Kyohei Muguruma, Mayu Ito, Akane Fukuda, Satoshi Kishimoto, Akihiro Taguchi, Kentaro Takayama, Atsuhiko Taniguchi, Yuji Ito and Yoshio Hayashi
- Journal Title
  
  Med. Chem. Commun.
  
  Volume: 10 Issue: 10 Pages: 1789-1795
- DOI
  10.1039/c9md00294d
- Data Source
  KAKENHI-PROJECT-19H03356
[Journal Article] Kinetics-based structural requirements of human immunoglobulin G binding peptides2019
- Author(s)
  Kyohei Muguruma, Konomi Fujita, Akane Fukuda, Satoshi Kishimoto, Soichiro Sakamoto, Risako Arima, Mayu Ito, Mayu Kawasaki, Shogo Nakano, Sohei Ito, Kanade Shimizu, Akihiro Taguchi, Kentaro Takayama, Atsuhiko Taniguchi, Yuji Ito, Yoshio Hayashi
- Journal Title
  
  ACS Omega
  
  Volume: 4 Issue: 11 Pages: 14390-14397
- DOI
  10.1021/acsomega.9b01104
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03356, KAKENHI-PROJECT-18K14391
[Journal Article] Development of Potent Myostatin Inhibitory Peptides through Hydrophobic Residue-Directed Structural Modification2017
- Author(s)
  Takayama Kentaro、Rentier Cedric、Asari Tomo、Nakamura Akari、Saga Yusuke、Shimada Takahiro、Nirasawa Kei、Sasaki Eri、Muguruma Kyohei、Taguchi Akihiro、Taniguchi Atsuhiko、Negishi Yoichi、Hayashi Yoshio
- Journal Title
  
  ACS Medicinal Chemistry Letters
  
  Volume: 8 Issue: 7 Pages: 751-756
- DOI
  10.1021/acsmedchemlett.7b00168
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K13260, KAKENHI-PROJECT-15H04658, KAKENHI-PROJECT-16F16413
[Journal Article] Structural basis for the effective myostatin inhibition of the mouse myostatin prodomain-derived minimum peptide2017
- Author(s)
  Tomo Asari, Kentaro Takayama, Akari Nakamura, Takahiro Shimada, Akihiro Taguchi and Yoshio Hayashi
- Journal Title
  
  ACS Med. Chem. Lett.
  
  Volume: 8 Issue: 1 Pages: 113-117
- DOI
  10.1021/acsmedchemlett.6b00420
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H04658
[Journal Article] Click strategy using disodium salts of amino acids improves the water solubility of plinabulin and KPU-3002017
- Author(s)
  Fumika Yakushiji, Kyohei Muguruma, Yoshiki Hayashi, Takuya Shirasaka, Ryosuke Kawamata, Hironari Tanaka, Yushi Yoshiwaka, Akihiro Taguchi, Kentaro Takayama, Yoshio Hayashi
- Journal Title
  
  Bioorganic Medicinal Chemistry
  
  Volume: 25 Issue: 14 Pages: 3623-3630
- DOI
  10.1016/j.bmc.2017.04.024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K15145
[Journal Article] Neuromedin U suppresses glucose-stimulated insulin secretion in pancreatic β cells.2017
- Author(s)
  Zhang W, Sakoda H, Miura A, Shimizu K, Mori K, Miyazato M, Takayama K, Hayashi Y, Nakazato M.: Neuromedin U
- Journal Title
  
  Biochem Biophys Res Commun,
  
  Volume: 493 Issue: 1 Pages: 677-683
- DOI
  10.1016/j.bbrc.2017.08.132
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09761, KAKENHI-PROJECT-17K16051, KAKENHI-PROJECT-15H04658, KAKENHI-PROJECT-16H05333, KAKENHI-PROJECT-15K09445
[Journal Article] Discovery of a Human Neuromedin U Receptor 1-Selective Hexapeptide Agonist with Enhanced Serum Stability2017
- Author(s)
  Takayama Kentaro、Mori Kenji、Tanaka Akiko、Nomura Erina、Sohma Yuko、Mori Miwa、Taguchi Akihiro、Taniguchi Atsuhiko、Sakane Toshiyasu、Yamamoto Akira、Minamino Naoto、Miyazato Mikiya、Kangawa Kenji、Hayashi Yoshio
- Journal Title
  
  Journal of Medicinal Chemistry
  
  Volume: 60 Issue: 12 Pages: 5228-5234
- DOI
  10.1021/acs.jmedchem.7b00694
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04658, KAKENHI-PROJECT-15K09445
[Journal Article] Effect of N-terminal acylation on the activity of myostatin inhibitory peptides2016
- Author(s)
  Kentaro Takayama, Akari Nakamura, Cédric Rentier, Yusaku Mino, Tomo Asari, Yusuke Saga, Akihiro Taguchi, Fumika Yakushiji and Yoshio Hayashi
- Journal Title
  
  ChemMedChem
  
  Volume: 11 Issue: 8 Pages: 845-849
- DOI
  10.1002/cmdc.201500533
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H04658
[Journal Article] Identification of a degrading enzyme in human serum that hydrolyzes a C-terminal core sequence of neuromedin U2016
- Author(s)
  Kentaro Takayama, Akihiro Taguchi, Fumika Yakushiji, and Yoshio Hayashi
- Journal Title
  
  Biopolymers
  
  Volume: - Issue: 4 Pages: 440-445
- DOI
  10.1002/bip.22770
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H04658
[Journal Article] The Inhibitory Core of the Myostatin Prodomain: Its Interaction with Both Type I and II Membrane Receptors, and Potential to Treat Muscle Atrophy.2015
- Author(s)
  Ohsawa Y, Takayama K, Nishimatsu S, Okada T, Fujino M, Fukai Y, Murakami T, Hagiwara H, Itoh F, Tsuchida K, Hayashi Y, Sunada Y.
- Journal Title
  
  PLoS One
  
  Volume: 10 Issue: 7 Pages: e0133713-e0133713
- DOI
  10.1371/journal.pone.0133713
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K09330, KAKENHI-PROJECT-26461285, KAKENHI-PROJECT-15H04658
[Journal Article] Development of cyclic didehydrodipeptide-type novel anti-microtubule agents possessing 2-pyridyl and benzophenone structures2015
- Author(s)
  Yoshiki Hayashi
- Journal Title
  
  Peptide Science 2014, The Japanese Peptide Society (2015) in press
  
  Volume: 2014 Pages: 243-244
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390029
[Journal Article] KPU-300, a novel benzophenone－diketopiperazine－type anti-microtubule agent with a 2-pyridyl structure, is a potent radiosensitizer that synchronizes the cell cycle in early M phase.2015
- Author(s)
  Okuyama K, Kaida A, Hayashi Y, Hayashi Y, Harada K, Miura M
- Journal Title
  
  PLoS One
  
  Volume: 10 Issue: 12 Pages: e0145995-e0145995
- DOI
  10.1371/journal.pone.0145995
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26293399
[Journal Article] Structure－Activity Relationship Studies of 3-epi-Deoxynegamycin Derivatives as Potent Readthrough Drug Candidates2015
- Author(s)
  Keisuke Hamada, Akihiro Taguchi, Masaya Kotake, Suguru Aita, Saori Murakami, Kentaro Takayama, Fumika Yakushiji, Yoshio Hayashi
- Journal Title
  
  ACS Medicinal Chemistry Letters
  
  Volume: 6 Issue: 6 Pages: 689-694
- DOI
  10.1021/acsmedchemlett.5b00121
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-26102740
[Journal Article] Discovery of Natural Products Possessing Selective Eukaryotic Readthrough Activity: 3-epi-Deoxynegamycin and Its Leucine Adduct2014
- Author(s)
  Akihiro Taguchi, Keisuke Hamada, Masaya Kotake, Masataka Shiozuka, Hidemasa Nakaminami, Thanigaimalai Pillaiyar, Kentaro Takayama, Fumika Yakushiji, Norihisa Noguchi, Takeo Usui, Ryoichi Matsuda, Yoshio Hayashi
- Journal Title
  
  ChemMedChem
  
  Volume: 9 Issue: 10 Pages: 2233-2237
- DOI
  10.1002/cmdc.201402208
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25893258, KAKENHI-PUBLICLY-26102740
[Journal Article] Development of a New Benzophenone-diketopiperazine-type Potent Anti-microtubule Agent Possessing a 2-Pyridine Structure2014
- Author(s)
  Yoshiki Hayashi
- Journal Title
  
  ACS Med Chem Lett
  
  Volume: 5 Pages: 1094-1098
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-23390029
[Journal Article] Development of a new benzophenone-diketopiperazine-type potent antimicrotubule agent possessing a 2-pyridine structure.2014
- Author(s)
  Hayashi Y, Takeno H, Chinen T, Muguruma K, Okuyama K, Taguchi A, Takayama K, Yakushiji F, Miura M, Usui T, Hayashi Y.
- Journal Title
  
  ACS Med Chem Lett.
  
  Volume: 5 Issue: 10 Pages: 1094-1098
- DOI
  10.1021/ml5001883
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-12J01199, KAKENHI-PROJECT-25670796, KAKENHI-PROJECT-26293399
[Journal Article] Design and synthesis of new tripeptide-type SARS-CoV 3CL protease inhibitors containing an electrophilic arylketone moiety2013
- Author(s)
  S. Konno, P. Thanigaimalai, Shen-En Chen, Ernesto Freire, Y. Hayashi, 他9名
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 21 Issue: 2 Pages: 412-424
- DOI
  10.1016/j.bmc.2012.11.017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11F01104, KAKENHI-PROJECT-21249007, KAKENHI-PROJECT-23659059, KAKENHI-PROJECT-25460160
[Journal Article] Medicinal chemistry and chemical biology of diketopiperazine-type anti-microtubule and vascular disrupting agents2013
- Author(s)
  Yoshio Hayashi
- Journal Title
  
  Chem. Pharm. Bull
  
  Volume: 61 Pages: 889-901
- NAID
  130003360830
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390029
[Journal Article] Design, synthesis, and biological evaluation of novel dipeptide-type SARS-CoV 3CL protease inhibitors: Structure–activity relationship study2013
- Author(s)
  Pillaiyar Thanigaimalai
- Journal Title
  
  European Journal of Medicinal Chemistry
  
  Volume: in press Pages: 999-999
- DOI
  10.1016/j.ejmech.2013.05.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659059, KAKENHI-PROJECT-25460160
[Journal Article] Design, synthesis and evaluation of tripeptidommimetics with arylketone as inhibitors of SARS-CoV 3CL protease2012
- Author(s)
  Sho Konno, Yoshio Hayashi 他10名
- Journal Title
  
  Peptide Science 2011
  
  Volume: 2012 Pages: 151-154
- Data Source
  KAKENHI-PROJECT-23659059
[Journal Article] Negamycin Analogue with Readthrough-Promoting Activity as a Potential Drug Candidate for Duchenne Muscular Dystrophy2012
- Author(s)
  Akihiro Taguchi, Yoshio Hayashi, 他10人
- Journal Title
  
  ACS Med.Chem.Lett.
  
  Volume: 3 Pages: 118-122
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390029
[Journal Article] Development of a solidsupported biotinylation reagent for efficient biotin labeling of SH groups on small molecules2012
- Author(s)
  Kentarou Fukumoto, Kumi Adachi, Akihiro Kajiyama, Yuri Yamazaki, Fumika Yakushiji, Yoshio Hayashi
- Journal Title
  
  Tetrahedron Lett
  
  Volume: 53 Issue: 5 Pages: 535-538
- DOI
  10.1016/j.tetlet.2011.11.089
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659059, KAKENHI-PROJECT-23790142, KAKENHI-PROJECT-23790143
[Journal Article] Synthesis and Structure-Activity Relationship Study of Antimicrotubule Agents Phenylahistin Derivatives with a Didehydropiperazine-2,5-dione Structure2012
- Author(s)
  Y.Yamazaki
- Journal Title
  
  Journal of Medicinal Chemistry
  
  Volume: 55 Issue: 3 Pages: 1056-1071
- DOI
  10.1021/jm2009088
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-23102013, KAKENHI-PROJECT-23390029, KAKENHI-PROJECT-23790142, KAKENHI-PROJECT-23790143
[Journal Article] Unusual expression of red fluorescence at M phase induced by anti-microtubule agents in HeLa cells expressing the fluorescent ubiquitination-based cell cycle indicator (Fucci)2012
- Author(s)
  Asumi Honda-Uezono
- Journal Title
  
  Biochem. Biophys. Res. Commun
  
  Volume: 428 Issue: 2 Pages: 224-229
- DOI
  10.1016/j.bbrc.2012.10.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390029, KAKENHI-PROJECT-23390427
[Journal Article] Water-Soluble Prodrug of Antimicrotubule Agent Plinabulin : Effective strategy with Click Chemistry2011
- Author(s)
  Fumika Yakushiji, Yoshio Hayashi, 他4人
- Journal Title
  
  Chemistry-A European Journal
  
  Volume: 17 Issue: 45 Pages: 12587-12590
- DOI
  10.1002/chem.201102293
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390029, KAKENHI-PROJECT-23790142
[Journal Article] Development of [Ile40] HTLV-I protease inhibition assay using novel fluorogenic and chromogenic substrate2011
- Author(s)
  Henri-Obadja Kumada, Yoshio Hayashi Yoshiaki Kiso, 他4人
- Journal Title
  
  Journal Peptide Science
  
  Volume: 17 Pages: 569-575
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390029
[Journal Article] Tubulin Photoaffinity Labeling Study with a Plinabulin Chemical Probe Possessing a Biotin Tag at the Oxazole2011
- Author(s)
  Yuri Yamazaki, Yoshio Hayashi, 他5人
- Journal Title
  
  Bioorg.Med.Chem.
  
  Volume: 19 Pages: 595-602
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390036
[Journal Article] Tubulin photoaffinity labeling study with a plinabulin chemical probe possessing a bitin tag at the oxazole.2011
- Author(s)
  Yamazaki, Y., Kido, Y., Hidaka, K., Yasui, H., Kiso, Y., Yakushiji, F., Hayashi, Y.
- Journal Title
  
  Bioorg.Med.Chem. 19
  
  Pages: 595-602
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390036
[Journal Article] Tubulin photoaffinity labeling study with a plinabulin chemical probe possessing a bitin tag at the oxazole2011
- Author(s)
  Yamazaki, Y., Kido, Y., Hidaka, K., Yasui, H., Kiso, Y., Yakushiji, F., Hayashi, Y.
- Journal Title
  
  Bioorg. Med. Chem
  
  Volume: 19 Pages: 595-602
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390036
[Journal Article] 生物分子システムを基盤とする統合創薬科学2010
- Author(s)
  木曽良明, 林良雄, 相馬洋平, 日高興士
- Journal Title
  
  MEDCHEM NEWS
  
  Volume: 20 Pages: 2-8
- NAID
  130007944525
- Data Source
  KAKENHI-PROJECT-20390036
[Journal Article] Anti-microtubule "plinabulin" chemical probe KPU-244-B3 labeled both a-and b-tubulin2010
- Author(s)
  Yamazaki, Y., Sumikura, M., Hidaka, K., Yasui, H., Kiso, Y., Yakushiji, F., Hayashi, Y.
- Journal Title
  
  Bioorg. Med. Chem
  
  Volume: 18 Pages: 3169-3174
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390036
[Journal Article] Anti-microtubule "plinabulin" chemical probe KPU-244-B3 labeled both a-and b-tubulin.2010
- Author(s)
  Yamazaki, Y., Sumikura, M., Hidaka, K., Yasui, H., Kiso, Y., Yakushiji, F., Hayashi, Y.
- Journal Title
  
  Bioorg.Med.Chem. 18
  
  Pages: 3169-3174
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390036
[Journal Article] Total synthesis of (+)-negamycin and its 5-epi-derivative2010
- Author(s)
  Nishiguchi, S. ; Kiso, Y. ; Hayashi, Y. ; , 他7名
- Journal Title
  
  Tetrahedron 66
  
  Pages: 314-320
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20659017
[Journal Article] Anti-microtubule 'Plinabulin' Chemical Probe KPU-244-B3 Labeled Both α- and β-Tubulin2010
- Author(s)
  Yuri Yamazaki, Yoshio Hayashi, 他5人
- Journal Title
  
  Bioorg.Med.Chem.
  
  Volume: 18 Pages: 3169-3174
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390036
[Journal Article] Synthesis and Antimicrobial Activity of (+)-Negamycin Derivatives Focused on the Hydrazine Amide Moiety2010
- Author(s)
  Taguchi, A. ; Ina, M., Hayashi, Y. ; , 他4名
- Journal Title
  
  Peptide Science 2009 2009
  
  Pages: 317-318
- Data Source
  KAKENHI-PROJECT-20659017
[Journal Article] Acid catalyzed monodehydro-2, 5-diketopiperazine formation from N-α-ketoacyl amino acid amides.2009
- Author(s)
  Yamazaki, Y., Mori, Y., Oda, A., Okuno, Y., Kiso, Y., Hayashi, Y.
- Journal Title
  
  Tetrahedron 65
  
  Pages: 3688-3694
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390036
[Journal Article] Acid catalyzed mono-dehydro-2, 5-diketopiperazine formation from N-α-ketoacyl amino acid amides2009
- Author(s)
  Yamazaki, Y., Mori, Y., Oda, A., Okuno, Y., Kiso, Y., Hayashi, Y.
- Journal Title
  
  Tetra-hedron
  
  Volume: 65 Pages: 3688-3694
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390036
[Journal Article] Synthesis and structure-activity relationship study of cyclic dipeptide-based microtubule depolymerization agents with a benzophenone structure2009
- Author(s)
  Sumikura, M., Yamazaki, Y., Yoshida, T., Mori, Y., Yasui, H., Kiso, Y., Neuteboom, S., Potts, B., Lloyd, G.K., Hayashi, Y.
- Journal Title
  
  Peptide Science 2009 2009(in press)
  
  Pages: 315-316
- Data Source
  KAKENHI-PROJECT-20390036
[Journal Article] Efficient Total Synthesis of Dipeptidic Antibiotics (+)-Negamycin and Its Derivatives2009
- Author(s)
  Hayashi, Y. ; Taguchi, A. ; Regnier, T. ; Nishiguchi, S. ; Kiso, Y.
- Journal Title
  
  Peptides 2009
  
  Pages: 278-279
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20659017
[Journal Article] Acid catalyzed monodehydro-2,5-diketopiperazine formation toward natural product synthesis2009
- Author(s)
  Yamazaki, Y., Mori, Y., Oda, A., Kiso, Y., Hayashi, Y.
- Journal Title
  
  Peptides 2009
  
  Pages: 54-55
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390036
[Journal Article] Metabolism of phenylahistin enantiomers by cytochromes P450 : a possible explanation for their different cytotoxicity2008
- Author(s)
  Lionel Perrin, Yoshio Hayashi, Marcel Delaforge, 他5人
- Journal Title
  
  Drug Metabolism and Disposition 36
  
  Pages: 2381-2392
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390036
[Journal Article] Tubulin Photoaffinity Labeling by Biotin-Tagged Derivatives of Potent Diketopiperazine Anti-Microtubule Agents.2008
- Author(s)
  Yuri Yamazaki, Yoshio Hayashi, 他9人
- Journal Title
  
  ChemBioChem 9(18)
  
  Pages: 3074-3081
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390036
[Journal Article] Oligoarginine-based prodrugs with self-cleavable spacers for Caco-2 cell permeation.2008
- Author(s)
  Takayama, K., Suehisa, Y., Fujita, T., Nguyen, J-T., Futaki, S., Yamamoto, A., Kiso, Y., Hayashi, Y.
- Journal Title
  
  Chem.Pharm.Bull. 56
  
  Pages: 1515-1520
- NAID
  110006968050
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390036
[Journal Article] Development of novel water-soluble photocleavable protective group and its application for design of photoresponsive paclitaxel prodrugs2008
- Author(s)
  Noguchi, M., Skwarczynski, M., Prakash, H., Hirota, S., Kimura, T., Hayashi, Y., Kiso, Y
- Journal Title
  
  Bioorg. Med Chem 16
  
  Pages: 5795-5802
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590099
[Journal Article] Efficient total synthesis of(+)-negamycin, a potential chemotherapeutic agent for genetic diseases.2008
- Author(s)
  Yoshio Hayashi, Thomas Regnie, Shigenobu Nishiguchi, 他9人
- Journal Title
  
  Chemical Communications 2008(20)
  
  Pages: 2379-2381
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20659017
[Journal Article] Tubulin Photoaffinity Labeling by Biotin-Tagged Derivatives of Potent Diketopiperazine Anti-Microtubule Agents.2008
- Author(s)
  Yamazaki, Y., Kohno, K., Yasui, H., Kiso, Y., Akamatsu, M., Nicholson, B., Deyanat-Yazdi, G., Neuteboom, S., Potts, B., Lloyd, G.K., Hayashi, Y.
- Journal Title
  
  ChemBioChem 9
  
  Pages: 3074-3081
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390036
[Journal Article] Oligoarginine-based prodrugs with self-cleavable spacers for Caco-2 cell permeation.2008
- Author(s)
  Kentaro Takayama, Yoshio Hayashi, 他6人
- Journal Title
  
  Chemical Pharmaceutical Bulletin 56(11)
  
  Pages: 1515-1520
- NAID
  110006968050
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390036
[Journal Article] Synthesis of negamycin and its derivatives as potential therapeutic agents for Duchenne muscular dystrophy2008
- Author(s)
  Yoshio Hayashi, Shigenobu Nishiguchi, 他10人
- Journal Title
  
  Peptide Science2007 2007
  
  Pages: 163-164
- NAID
  10021906785
- Data Source
  KAKENHI-PROJECT-20659017
[Journal Article] Development of new photoresponsive paclitaxel prodrug2008
- Author(s)
  Noguchi, M., Skwarczynski, M., Prakash, H., Hirota, S., Kimura, T., Hayashi, Y., Kiso, Y
- Journal Title
  
  Peptide Science 2007, S. Aimoto and S. Ono (Eds.), The Japanese Peptide Society
  
  Pages: 493-496
- NAID
  10021907399
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590099
[Journal Article] Oligoarginine-based prodrugs with self-cleavable spacers for Caco-2 cell permeation2008
- Author(s)
  Takayama, K., Suehisa, Y., Fujita, T., Nguyen, J-T., Futaki, S., Yamamoto, A., Kiso, Y., Hayashi, Y.
- Journal Title
  
  Chem. Pharm. Bull
  
  Volume: 56 Pages: 1515-1520
- NAID
  110006968050
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390036
[Journal Article] Tubulin Photoaffinity Labeling by Biotin-Tagged Derivatives of Potent Diketopiperazine Anti-Microtubule Agents2008
- Author(s)
  Yamazaki, Y., Kohno, K., Yasui, H., Kiso, Y., Akamatsu, M., Nicholson, B., Deyanat-Yazdi, G., Neuteboom, S., Potts, B., Lloyd, G. K., Hayashi, Y.
- Journal Title
  
  Chem Bio Chem
  
  Volume: 9 Pages: 3074-3081
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390036
[Journal Article] Development of oligoarginine-drug conjugates linked to new peptidic self-cleavable spacers toward effective intestinal absorption2007
- Author(s)
  Hayashi, Y., Takayama, K., Suehisa, Y., Fujita, T., Nguyen, J-T., Futaki, S., Yamamoto, A., Kiso, Y
- Journal Title
  
  Bioorg. Med. Chem. Lett 17-18
  
  Pages: 5129-5132
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590099
[Journal Article] Phototaxel : Development of first Photoresponsive prodrug of Paclitaxel via Modification of Phenylisoserine moiety2007
- Author(s)
  Skwarczynski, M. ; Noguchi, M. ; Hirota, S. ; Sohma, Y. ; Kimura, T. ; Hayashi, Y. ; Kiso, Y
- Journal Title
  
  Peptide Science 2006, H. Ishida and H. Mihara (Eds.), The Japanese Peptide Society
  
  Pages: 251-252
- NAID
  10020529808
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590099
[Journal Article] Development of first photoactivated prodrug of paclitaxel via modification of phenylisoserine moiety2007
- Author(s)
  Skwarczynnski, M., Noguchi, M., Hirota, S., Shoma, Y., Kimura, T., Hayashi, Y., Kiso, Y
- Journal Title
  
  PEPTIDES 2006, Rolka, K., Rekowski, P., Silberring, J. (Eds.), Proceedings of the twenty-ninth European Peptide Symposium
  
  Pages: 214-215
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590099
[Journal Article] Design and synthesis of oligo(D-arginine)-fluorescein conjugates possessing novel self-cleavable spacers as a model for effective intestinal absorption2007
- Author(s)
  Hayashi, Y., Takayama, K., Suehisa, Y., Fujita, T., Yamamoto, A., Futaki, S., Kiso, Y
- Journal Title
  
  Peptide Science 2006, H. Ishida and H. Mihara (Eds.), The Japanese Peptide Society
  
  Pages: 116-116
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590099
[Journal Article] アビジンービオチンアフィニティー科学の先駆け2007
- Author(s)
  山崎有里, 林良雄, 木曽良明
- Journal Title
  
  蛋白質核酸酵素 52
  
  Pages: 1784-1785
- Data Source
  KAKENHI-PROJECT-18032081
[Journal Article] Development of oligoarginine-drug conjugates linked to new peptidic self-cleavable spacers toward effective intestinal absorption2007
- Author(s)
  Hayashi, Y., Takayama, K., 他6名
- Journal Title
  
  Bioorg. Med. Chem. Lett. 17
  
  Pages: 5129-5132
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590099
[Journal Article] Application of O-N intramolecular carbon-carbamate migration Migrationof protective groups in amino acids and water-soluble prodrug strategy2007
- Author(s)
  Skwarczynnski, M., Sohma, Y., Noguchi, M., Kimura, T., Hayashi, Y., Kiso, Y
- Journal Title
  
  PEPTIDES 2006, Rolka, K., Rekowski, P., Silberring, J. (Eds.), Proceedings of the twenty-ninth European Peptide Symposium
  
  Pages: 204-205
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590099
[Journal Article] Development of oligoarginine-drug conjugates linked to new peptidic self-cleavable spacers toward effective intestinal absorption2007
- Author(s)
  Hayashi, Y., Takayama, K., 他6名
- Journal Title
  
  Bioorg.Med.Chem.Lett. 17
  
  Pages: 5129-5132
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590099
[Journal Article] New aspects of potent anti-microtubule agents phenylahistin and tubulin photoaffinity labeling2007
- Author(s)
  Hayashi, Y., Takayama, K., 他5名
- Journal Title
  
  Peptide Science 2007
  
  Pages: 116-116
- NAID
  10020529384
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590099
[Journal Article] O-N intramolecular alkoxycarbonyl migration of typical protective groups in hydroxyamino acids2006
- Author(s)
  Skwarczynski, M., Sohma, Y., Noguchi, M.,Kimura, T., Hayashi, Y., Kiso, Y
- Journal Title
  
  J. Org. Chem 71-6
  
  Pages: 2542-2545
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590099
[Journal Article] 0-N Intramolecular Acyloxy Migration Reaction:from the Prodrug to the Migration of Protective Groups in Amino Acids2006
- Author(s)
  Skwarczynski, M., Hayashi, Y., Kiso, Y., 他5名
- Journal Title
  
  Peptide Science 2006
  
  Pages: 169-172
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590099
[Journal Article] Application of intramolecular carbonate-carbamate migration2006
- Author(s)
  M.Skwarczynski, Y.Hayashi, Y.Kiso他3名
- Journal Title
  
  Chemistry Today 24・6
  
  Pages: 30-32
- Data Source
  KAKENHI-PROJECT-18032081
[Journal Article] Application of mtramolecular carbonate-carbamate migration2006
- Author(s)
  Skwarczynski, M., Noguchi, M., Sohma, Y., Kimura, T., Hayashi, Y., Kiso, Y
- Journal Title
  
  Chemistry Today 24-6
  
  Pages: 30-32
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590099
[Journal Article] Paclitaxel Prodrugs : Toward Smarter Delivery of Anticancer Agents2006
- Author(s)
  Skwarczynski, M., Hayashi, Y., Kiso, Y.
- Journal Title
  
  J.Med.Chem. 49・25
  
  Pages: 7253-7269
- Data Source
  KAKENHI-PROJECT-17590099
[Journal Article] Synthesis of glutamic acid and glutamine peptides possessing a trifluoromethyl ketone group as SARS-CoV 3CL protease inhibitors2006
- Author(s)
  Sydnes, M., S., Hayashi, Y., Sharma, V. K., Hamada, T., Bacha, U., Barrila, J., Freire, E., Kiso, Y
- Journal Title
  
  Tetrahedron 62-36
  
  Pages: 8601-8609
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590099
[Journal Article] Synthesis of glutamic acid and glutamine peptides possessing a trifluoromethyl ketone group as SARS-CoV 3CL protease inhibitors2006
- Author(s)
  Sydnes, M.S., Hayashi, Y.他6人
- Journal Title
  
  Tetrahedron 62・36
  
  Pages: 8601-8609
- Data Source
  KAKENHI-PROJECT-17590099
[Journal Article] Paclitaxel Prodrugs : Toward Smarter Delivery of Anticancer Agents2006
- Author(s)
  Skwarczynski, M., Hayashi, Y., Kiso, Y
- Journal Title
  
  J. Med. Chem 49-25
  
  Pages: 7253-7269
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590099
[Journal Article] O-N Intramolecular Acyloxy Migration Reaction : from the Prodrug to the Migration of Protective Groups in Amino Acids2006
- Author(s)
  Skwarczynski, M., Shoma, Y., Noguchi, M., Kimura, M., Hayashi, Y., Hamada, Y., Kimura, T., Kiso, Y
- Journal Title
  
  Peptide Science 2005, T. Wakamiya (Ed.), The Japanese Peptide Society
  
  Pages: 169-172
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590099
[Journal Article] Synthesis ofglutamic acid and glutamine peptides possessing a trifluoromethyl ketone group as SARS-CoV 3CL rotease inhibitors2006
- Author(s)
  Sydnes, M.S., Hayashi, Y., 他6人
- Journal Title
  
  Tetrahedron 62・36
  
  Pages: 8601-8609
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590099
[Journal Article] Application of intramolecular carbonate-carbamate migration2006
- Author(s)
  Skwarczynski, M., Hayashi, Y., Kiso, Y., 他3名
- Journal Title
  
  Chemistry Today 24
  
  Pages: 30-32
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590099
[Journal Article] Uptake Mechanism of FITC-Oligoarginine conjugate in Hela cells2006
- Author(s)
  Y.Suehisa, Y.Hayashi他6名
- Journal Title
  
  Peptide Science 2006
  
  Pages: 366-366
- NAID
  10020530395
- Data Source
  KAKENHI-PROJECT-18032081
[Journal Article] Development of first photoresponsive prodrug of pachtaxel2006
- Author(s)
  Skwarczynski, M., Noguchi, M., Hirota, S., Sohma, Y., Kimura, T., Hayashi, Y., Kiso, Y
- Journal Title
  
  Bioorg. Med. Chem Lett 16-17
  
  Pages: 4492-4496
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590099
[Journal Article] Development of Wang Resin Supported Evans-type Oxazolidinone for Asymmetric Reaction2006
- Author(s)
  Tomoya Kotake, Yoshio Hayashi, 他3名
- Journal Title
  
  PEPTIDES 2006
  
  Pages: 96-97
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590099
[Journal Article] New aspect of potent anti-microtubule agents phenylahistin and tubulin photoaffinity labeling2006
- Author(s)
  Y.Hayashi他10名
- Journal Title
  
  Peptide Science 2006
  
  Pages: 159-159
- NAID
  10020529384
- Data Source
  KAKENHI-PROJECT-18032081
[Journal Article] O-N Intramolecular alkoxycarbonyl migration of typical protective groups in hydroxyamino acids2006
- Author(s)
  M. Skwarczynski, Y. Sohma, Y. Hayashi, 他4名
- Journal Title
  
  Journal of Organic Chemistry 71
  
  Pages: 2542-2545
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590099
[Journal Article] Desinn and synthesis of oligoarginine-fluorescein conjugate possessing novel self-cleavable spacers as a model for effective intestinal absorption2006
- Author(s)
  Y.Hayashi他6名
- Journal Title
  
  Peptide Science 2006
  
  Pages: 116-116
- Data Source
  KAKENHI-PROJECT-18032081
[Journal Article] Paclitaxel Prodrugs:Toward Smarter Delivery of Anticancer Agents2006
- Author(s)
  Skwarczynski, M., Hayashi, Y., Kiso, Y.
- Journal Title
  
  J.Med.Chem. 49・25
  
  Pages: 7253-7269
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590099
[Journal Article] Development of first photoresponsive prodrug of paclitaxel2006
- Author(s)
  Skwarczynski, M., Hayashi, Y., Kiso, Y.他4名
- Journal Title
  
  Bioorg.Med.Chem.Lett. 16・17
  
  Pages: 4492-4496
- Data Source
  KAKENHI-PROJECT-17590099
[Journal Article] "Click Peptide" Based on the "O-Acyl Isopeptide Method" : Control of A1-42 Production from a Photo-Triggered A1-42 Analogue2006
- Author(s)
  A.Taniguchi, Y.Sohma, M.Kimura, Y.Hayashi, 他6名
- Journal Title
  
  Journal of American Chemical Society 128・3
  
  Pages: 696-697
- Data Source
  KAKENHI-PROJECT-17035085
[Journal Article] O-N Intramolecular alkoxycarbonyl migration of typical protective groups in hydroxyamino acids2006
- Author(s)
  M.Skwarczynski, Y.Sohma, Y.Hayashi, 他4名
- Journal Title
  
  Journal of Organic Chemistry 71・6
  
  Pages: 2542-2545
- Data Source
  KAKENHI-PROJECT-17590099
[Journal Article] NPI-2358 is a tubulin-depolymerizing agent : in-vitro evidence for activity sa a tumor vascular-disrupting agent2006
- Author(s)
  B.Nicolson, G.K.Lloyd, Y.Hayashi, 他4名
- Journal Title
  
  Anti-Cancer Drugs 17・1
  
  Pages: 25-31
- Data Source
  KAKENHI-PROJECT-17035085
[Journal Article] Development of first photoresponsive prodrug of paclitaxel2006
- Author(s)
  Skwarczynski, M., Hayashi, Y., Kiso, Y., 他4名
- Journal Title
  
  Bioorg.Med.Chem.Lett. 16
  
  Pages: 4492-4496
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590099
[Journal Article] Design and Synthesis of a New Polymer-supported Evans-type Oxazolidinone : An Efficient Chiral Auxiliary in the Solid-phase Asymmetric Alkylation Reactions.2005
- Author(s)
  T.Kotake, Y.Hayashi, S.Rajesh, 他4名
- Journal Title
  
  Tetrahedron 61・15
  
  Pages: 3810-3833
- Data Source
  KAKENHI-PROJECT-15590102
[Journal Article] Conversion of polymer-bound dipeptide to Evans-type chiral auxiliary a new tool for efficient solid-phase asymmetric reactions2005
- Author(s)
  Kotake, T., Hayashi, Y., Takiguchi, Y., Kimura, T., Kiso, Y
- Journal Title
  
  Peptide Science 2004, Y. Shimohigashi (Ed.), The Japanese Peptide Society
  
  Pages: 629-632
- NAID
  10014460730
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590099
[Journal Article] Design and Synthesis of a New Polymer-supported Evans-type Oxazolidinone:An Efficient Chiral Auxiliary in the Solid-hase Asymmetric Alkylation Reactions2005
- Author(s)
  T. Kotake, Y. Hayashi, 他5名
- Journal Title
  
  Tetrahedron 61
  
  Pages: 3819-3833
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590099
[Journal Article] Effect of the Phenyl Ring Modification on the Antitumor Activity of Anti-Microtubule Agent Dehydrophenylahistin2005
- Author(s)
  Yoshio Hayashi et al.
- Journal Title
  
  Peptide Science 2004
  
  Pages: 405-406
- NAID
  10014460313
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590102
[Journal Article] Effect of the Phenyl Ring Modification on the Antitumor Activity of Anti-Microtubule Agent Dehydrophenylahistin.2005
- Author(s)
  Yoshio Hayashi
- Journal Title
  
  Peptide Science 2004
  
  Pages: 405-406
- NAID
  10014460313
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590102
[Journal Article] Development of Wang Resin Supported Evans-type Oxazolidinone for Asymmetric Reaction2005
- Author(s)
  Kotake, T., Hayashi, Y., Rajesh, S., Kimura, T., Kiso, Y
- Journal Title
  
  PEPTIDES, pp96-97 (2006), Proceedings of the 19th American Peptide Symposium, Sylvie E. Blondelle (Ed.) American Peptide Society
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590099
[Journal Article] The ‘O-acyl isopeptide method' for the synthesis of difficult sequence-containing peptides : application to the synthesis of Alzheimer's disease-related amyloid β-peptide (Aβ) 1-42,2005
- Author(s)
  Y.Sohma, Y.Hayashi, 他6名
- Journal Title
  
  Journal Peptide Science 11・8
  
  Pages: 441-451
- Data Source
  KAKENHI-PROJECT-17035085
[Journal Article] O-N Intramolecular acyl acyloxy migration reaction in the development of water-soluble prodrugs of taxoids2005
- Author(s)
  M. Skwarczynski, Y. Sohma, Y. Hayashi, 他5名
- Journal Title
  
  Peptide Science 2004
  
  Pages: 309-312
- NAID
  10014460093
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590099
[Journal Article] No auxiliary, no byproduct strategy for water-soluble prodrugs of taxoids : scope and limitation of O-N intramolelcular acyl and acyloxy migration reaction2005
- Author(s)
  M.Skwarczynski, Y.Sohma, Y.Hayashi, 他5名
- Journal Title
  
  Journal of Medicinal Chemistry 48・7
  
  Pages: 2655-2666
- Data Source
  KAKENHI-PROJECT-17590099
[Journal Article] Conversion ofpolymer-bound dipeptide to Evans-type chhal auxiliary:a new tool for efficient solid-hase asymmetric reactions2005
- Author(s)
  Tomoya Kotake, Yoshio Hayashi, 他3名
- Journal Title
  
  Peptide Science 2004
  
  Pages: 629-632
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590099
[Journal Article] No Auxiliary, No Byproduct Strategy for Water-soluble Prodrugs of Taxoids Scope and Limitation of O-N Intramolecular Acyl and Acyloxy Migration Reaction2005
- Author(s)
  Skwarczynski, M., Sohma, Y., Noguchi, M., Kimura, M., Hayashi, Y., Kimura, T., Kiso, Y
- Journal Title
  
  J Med Chem 48-7
  
  Pages: 2655-2666
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590099
[Journal Article] No Auxiliary, No Byproduct Strategy for Water-soluble Prodrugs of Taxoids : Scope and Limitation of O-N Intramolecular Acyl and Acyloxy Migration Reaction.2005
- Author(s)
  M.Skwarczynski, Y.Sohma, Y.Hayashi, 他4名
- Journal Title
  
  Journal of Medicinal Chemistry (in press)
- Data Source
  KAKENHI-PROJECT-15590102
[Journal Article] No auxiliary, no byproduct strategy for water-soluble prodrugs of taxoids:scope and limitation おf O-N intramolelcular acyl and acyloxy migration reaction2005
- Author(s)
  M.Skwarczynski, Y.Sohma, Y.Hayashi, 他5名
- Journal Title
  
  Journal of Medicinal Chemistry 48
  
  Pages: 2655-2666
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590099
[Journal Article] Conversion of polymer-bound dipeptide to Evans-type chiral auxiliary : a new tool for efficient solid-phase asymmetric reactions2005
- Author(s)
  Tomoya Kotake, Yoshio Hayashi, 他3名
- Journal Title
  
  Peptide Science 2004
  
  Pages: 629-632
- NAID
  10014460730
- Data Source
  KAKENHI-PROJECT-17590099
[Journal Article] Effect of the phenyl ring modification on the antitumor activity of anti-microtubule agent dehydrophenylahistin2005
- Author(s)
  Y.Hayashi, B.Nicholson, K.Tanaka, A.Oda, G.K.Lloyd, 他3名
- Journal Title
  
  Peptide Science 2004
  
  Pages: 405-406
- NAID
  10014460313
- Data Source
  KAKENHI-PROJECT-17035085
[Journal Article] O-N Intramolecular acyl amd acyloxy migration reaction in the development of water-soluble prodrugs of taxoids2005
- Author(s)
  M.Skwarczynski, Y.Sohma, Y.Hayashi, 他5名
- Journal Title
  
  Peptide Science 2004
  
  Pages: 309-312
- Data Source
  KAKENHI-PROJECT-17590099
[Journal Article] Design and Synthesis of a New Polymer-supported Evans-type Oxazolidinone : An Efficient Chiral Auxiliary in the Solid-phase Asymmetric Alkylation Reactions2005
- Author(s)
  Kotake, T., Hayashi, Y., Rajesh, S., Mukai, Y., Takiguchi, Y., Kimura, T., Kiso, Y
- Journal Title
  
  Tetrahedron 61-15
  
  Pages: 3819-3833
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590099
[Journal Article] O-N Intramolecular acyl amd acyloxy migration reaction in the development of water-soluble prodrugs of taxoids2005
- Author(s)
  Skwarczynski, M., Sohma, Y., Noguchi, M., Kimura, M., Hayashi, Y., Hamada, Y., Kimura, T., Kiso, Y
- Journal Title
  
  Peptide Science 2004, Y. Shimohigashi (Ed.), The Japanese Peptide Society
  
  Pages: 309-312
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590099
[Journal Article] Development of new water-soluble prodrugs based on intramolecular nucleophilic reactions in peptide chemistry2004
- Author(s)
  Yoshio Hayashi et al.
- Journal Title
  
  Peptide Science 2003
  
  Pages: 73-76
- NAID
  10012653884
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590102
[Journal Article] Design and Synthesis of a Novel Water-soluble Aβ1-42 Isopeptide : An Efficient Strategy for the Preparation of Alzhemeir's Disease-related Peptide, Aβ1-42, via O-N Intramolecular Acyl Migration Reaction.2004
- Author(s)
  Y.Sohma, M.Sasaki, Y.Hayashi, 他2名
- Journal Title
  
  Tetrahedron Letters 45・31
  
  Pages: 5965-5968
- Data Source
  KAKENHI-PROJECT-15590102
[Journal Article] A New Polymer-supported Evans'-Type Chiral Auxiliary Derived from α-Hydroxy-β-amino Acid, Phenylnorstatine : Synthesis and Application in Asymmetric Alkylation Reaction.2004
- Author(s)
  T.Kotake, S.Rajesh, Y.Hayashi, 他3名
- Journal Title
  
  Tetrahedron Letters 45・18
  
  Pages: 3651-3654
- Data Source
  KAKENHI-PROJECT-15590102
[Journal Article] Development of New Water-soluble Prodrugs Based on Intramolecular Nucleophilic Reactions in Peptide Chemistry.2004
- Author(s)
  Yoshio Hayashi
- Journal Title
  
  Peptide Science 2003
  
  Pages: 73-76
- NAID
  10012653884
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590102
[Journal Article] A Novel Approach of Water-Soluble Paclitaxel Prodrug with No Auxiliary and No By-product : Design and Synthesis of Isotaxel.2003
- Author(s)
  Yoshio Hayashi
- Journal Title
  
  Journal Medicinal Chemistry 46
  
  Pages: 3782-3784
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590102
[Journal Article] A Novel Approach of Water-Soluble Paclitaxel Prodrug with No Auxiliary and No By-product : Design and Synthesis of Isotaxel2003
- Author(s)
  Yoshio Hayashi et al.
- Journal Title
  
  Journal of Medicinal Chemistry 46(18)
  
  Pages: 3782-3784
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590102
[Patent] ネガマイシン誘導体2021
- Inventor(s)
  林良雄、田口晃弘ら
- Industrial Property Rights Holder
  東京薬科大学など
- Industrial Property Rights Type
  特許
- Filing Date
  2021
- Overseas
- Data Source
  KAKENHI-PROJECT-19H03356
[Patent] Peptide or pharmaceutically acceptable salts or prodrugs thereof2018
- Inventor(s)
  林　良雄、高山　健太郎、宮里　幹也、寒川　賢治、森　健二ら7名
- Industrial Property Rights Holder
  学校法人東京薬科大学、国立研究開発法人国立循環器病研究センター他
- Industrial Property Rights Type
  特許
- Filing Date
  2018
- Overseas
- Data Source
  KAKENHI-PROJECT-15H04658
[Patent] Peptide or pharmaceutically acceptable salts or prodrugs and applications thereof2018
- Inventor(s)
  林　良雄、高山　健太郎、宮里　幹也、寒川　賢治、森　健二
- Industrial Property Rights Holder
  学校法人東京薬科大学、国立研究開発法人国立循環器病研究センター
- Industrial Property Rights Type
  特許
- Filing Date
  2018
- Overseas
- Data Source
  KAKENHI-PROJECT-15H04658
[Patent] Peptide or pharmaceutically acceptable salts or prodrugs thereof2017
- Inventor(s)
  林　良雄、高山　健太郎、根岸　洋一
- Industrial Property Rights Holder
  学校法人東京薬科大学
- Industrial Property Rights Type
  特許
- Filing Date
  2017
- Overseas
- Data Source
  KAKENHI-PROJECT-15H04658
[Patent] ペプチド、その薬学的に許容される塩、またはそれらのプロドラッグ、およびそれらの用途2017
- Inventor(s)
  林良雄、高山健太郎、宮里幹也、寒川賢治、森健二
- Industrial Property Rights Holder
  林良雄、高山健太郎、宮里幹也、寒川賢治、森健二
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2017-008302
- Filing Date
  2017-01-20
- Data Source
  KAKENHI-PROJECT-15H04658
[Patent] ペプチドもしくはその薬学的に許容される塩、またはそれらのプロドラッグ2017
- Inventor(s)
  林良雄、高山健太郎、宮里幹也、寒川賢治、森健二、山本昌、坂根稔康
- Industrial Property Rights Holder
  林良雄、高山健太郎、宮里幹也、寒川賢治、森健二、山本昌、坂根稔康
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2017-008301
- Filing Date
  2017-01-20
- Data Source
  KAKENHI-PROJECT-15H04658
[Patent] ペプチドもしくはその薬学的に許容される塩、またはそれらのプロドラッグ2016
- Inventor(s)
  林良雄、高山健太郎、根岸洋一
- Industrial Property Rights Holder
  林良雄、高山健太郎、根岸洋一
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2016-158123
- Filing Date
  2016-08-10
- Data Source
  KAKENHI-PROJECT-15H04658
[Patent] マイオスタチン阻害ペプチド2014
- Inventor(s)
  林良雄他8名
- Industrial Property Rights Holder
  林良雄他8名
- Industrial Property Rights Type
  特許
- Filing Date
  2014-01-31
- Overseas
- Data Source
  KAKENHI-PROJECT-23390029
[Patent] 新規化合物、その製造方法及びその用途2013
- Inventor(s)
  林良雄他3名
- Industrial Property Rights Holder
  林良雄他3名
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2013-209166
- Filing Date
  2013-10-04
- Data Source
  KAKENHI-PROJECT-23390029
[Patent] 微小管脱重合剤2013
- Inventor(s)
  林良雄他4名
- Industrial Property Rights Holder
  林良雄他4名
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2013-159466
- Filing Date
  2013-07-31
- Data Source
  KAKENHI-PROJECT-23390029
[Patent] マイオスタチン阻害ペプチド2013
- Inventor(s)
  林良雄他8人
- Industrial Property Rights Holder
  林良雄他8人
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2013-017540
- Filing Date
  2013-01-31
- Data Source
  KAKENHI-PROJECT-23390029
[Patent] リードスルー活性を有する化合物2012
- Inventor(s)
  林良雄他４名
- Industrial Property Rights Holder
  林良雄他４名
- Industrial Property Rights Type
  特許
- Filing Date
  2012-11-30
- Overseas
- Data Source
  KAKENHI-PROJECT-23390029
[Patent] 終止コドンを読み飛ばす化合物2011
- Inventor(s)
  林良雄, 他5人
- Industrial Property Rights Holder
  東京薬科大学, 他1
- Industrial Property Number
  2011-263404
- Filing Date
  2011-12-02
- Data Source
  KAKENHI-PROJECT-23390029
[Patent] Preparation of dehydrophenylahistin analogs for treating vascular proliferatio2011
- Inventor(s)
  Yamazaki, Yuri; Hayashi, Yoshio
- Industrial Property Rights Holder
  Nereus Pharmaceuticals, Inc., USA
- Filing Date
  2011-07-14
- Overseas
- Data Source
  KAKENHI-PROJECT-23390029
[Patent] Dehydrophenylahistins And Analogs Thereof And The Synthesis Of Dehydrophenyla-histins And Analogs Thereof2010
- Inventor(s)
  Yoshio Hayashi, Michael A Palladino Jr, Jennifer Grodberg
- Industrial Property Rights Holder
  Nereus Pharmaceuticals
- Acquisition Date
  2010-03-09
- Overseas
- Data Source
  KAKENHI-PROJECT-20390036
[Patent] Synthesis Of Diketopiperazines2010
- Inventor(s)
  Yoshio Hayashi
- Industrial Property Rights Holder
  Nereus Pharmaceuticals
- Acquisition Date
  2010-06-08
- Data Source
  KAKENHI-PROJECT-20390036
[Patent] Dehydrophenylahistins And Analogs Thereof And The Synthesis Of Dehydrophenyla-histins And Analogs Thereof2010
- Inventor(s)
  Yoshio Hayashi, Michael A Palladino Jr, Jennifer Grodberg
- Industrial Property Rights Holder
  Nereus Pharmaceuticals
- Acquisition Date
  2010-03-09
- Data Source
  KAKENHI-PROJECT-20390036
[Patent] Synthesis Of Diketopiperazines2010
- Inventor(s)
  Yoshio Hayashi
- Industrial Property Rights Holder
  Nereus Pharmaceuticals
- Acquisition Date
  2010-06-08
- Overseas
- Data Source
  KAKENHI-PROJECT-20390036
[Patent] Analogs of dehydrophenylahistins and their therapeutic use and preparation2008
- Inventor(s)
  Michael A. Palladino, G. Kenneth Lloyd. Yoshio Hayashi
- Industrial Property Rights Holder
  Nereus Pharmaceuticals
- Filing Date
  2008-09-11
- Overseas
- Data Source
  KAKENHI-PROJECT-20390036
[Patent] Analogs of dehydrophenylahistins and their therapeutic use and preparation.2008
- Inventor(s)
  Michael A.Palladino, G.Kenneth Lloyd., Yoshio Hayashi
- Industrial Property Rights Holder
  Nereus Pharmacuticals
- Filing Date
  2008-09-11
- Data Source
  KAKENHI-PROJECT-20390036
[Patent] Preparation of dehydrophenylahistins and analogs for treat-ing vasculaz proliferarion2007
- Inventor(s)
  Palladino, M., Lloyd, G.K., Hayashi, Y.
- Industrial Property Rights Holder
  Nereus Pharmaceuticals
- Filing Date
  2007-04-05
- Overseas
- Data Source
  KAKENHI-PROJECT-18032081
[Patent] Preparation of dehydrophenylahistins and analogs for treat-ing vascular proliferation2007
- Inventor(s)
  Palladino, M., Lloyd, G.K., Hayashi, Y.
- Industrial Property Rights Holder
  Nereus Pharmaceuticals
- Acquisition Date
  2007-03-29
- Overseas
- Data Source
  KAKENHI-PROJECT-18032081
[Patent] 特許: Analogs of dehydrophenylahistins and their therapeutic use.2006
- Inventor(s)
  Y.Hayashi他2名
- Industrial Property Rights Holder
  Nereus Pharmaceu ticals, Inc
- Filing Date
  2006-09-20
- Data Source
  KAKENHI-PROJECT-18032081
[Patent] 特許:Synthesis of diketopiperazines by cyclization of a-keto acids.2006
- Inventor(s)
  Y.Hayashi
- Industrial Property Rights Holder
  Nereus Pharmaceu ticals, Inc.
- Filing Date
  2006-03-27
- Data Source
  KAKENHI-PROJECT-18032081
[Patent] Preparation of dehydrophenylahistins and analogs for treating vascular proliferation2005
- Inventor(s)
  M.A.Palladino, Y.Hayashi, 他2名
- Industrial Property Rights Holder
  Nereus Pharmaceuticals Inc.
- Filing Date
  2005-08-25
- Data Source
  KAKENHI-PROJECT-17035085
[Patent] Phenylahistin and phenylahistin analogs, a new class of antitumor compounds2004
- Inventor(s)
  Y.Hayashi, M.Palladino, J.Grodberg
- Industrial Property Rights Holder
  Nereus Pharmaceuticals, Inc.
- Filing Date
  2004-07-29
- Acquisition Date
  2005-02-10
- Data Source
  KAKENHI-PROJECT-15590102
[Patent] Phenylahistin and phenylahistin analogs, a new class of anti-tumor compounds2004
- Inventor(s)
  Y.Hayashi, M.Palladino, J.Grodberg
- Industrial Property Rights Holder
  Nereus Pharmaceuticals, Inc.
- Filing Date
  2004-07-29
- Acquisition Date
  2005-02-10
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590102
[Patent] Preparation of dehydrophenylahistins and analogs for treating cancer and fungal infection2003
- Inventor(s)
  Y.Hayashi, J.Grodberg, M.Palladino
- Industrial Property Rights Holder
  Nereus Pharmaceuticals, Inc.
- Filing Date
  2003-08-01
- Acquisition Date
  2004-11-25
- Data Source
  KAKENHI-PROJECT-15590102
[Patent] Preparation of dehydro-phenylahistins and analogs for treating cancer and fungal infection2003
- Inventor(s)
  Y.Hayashi, J.Grodberg, M.Palladino
- Industrial Property Rights Holder
  Nereus Pharmaceuticals, Inc.
- Filing Date
  2003-08-01
- Acquisition Date
  2004-11-25
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590102
[Presentation] トリプトファン残基を標的としたチオエーテル依存的スルフェニル化反応の開発2023
- Author(s)
  志田颯、田口晃弘、常田勇磨、崔岩、岸怜央、今野翔、谷口敦彦、林良雄
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-19H03356
[Presentation] SARS coronavirus 3CL protease inhibitors with an electrophilic aryl-ketone warhead2023
- Author(s)
  Yoshio Hayashi
- Organizer
  International Conference on Recent Advances in Materials Chemistry and Catalysis (RAMCC- 2023), Dibrugarh University, Assam, India
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27305
[Presentation] SARS coronavirus 3CL protease inhibitors with an electrophilic aryl-ketone warhead2023
- Author(s)
  Sho Konno, Yoshio Hayashi, et al
- Organizer
  Recent Advances in Materials Chemistry and Catalysis (RAMCC-2023)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03356
[Presentation] D-ペプチドと光酸素化触媒からなる生体適合型マイオスタチン不活化剤の開発2023
- Author(s)
  池川馨、岡本英之、村野周子アンバー、勝山雅大、今野翔、田口晃弘、高山健太郎、谷口敦彦、林良雄
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-19H03356
[Presentation] 筋ジストロフィー由来ナンセンス変異に対するネガマイシン誘導体のリードスルー効率2023
- Author(s)
  大村紀子、田口晃弘、濵田圭佑、今野翔、谷口敦彦、林良雄
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-19H03356
[Presentation] SARS Coronavirus 3CL Protease Inhibitors with an Electrophilic Aryl-ketone Warhead2023
- Author(s)
  Yoshio Hayashi
- Organizer
  17th Chinese International Peptide Symposium (CPS2023) Tianjin, P.R. China
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27305
[Presentation] SARS Coronavirus 3CL Protease Inhibitors with an Electrophilic Aryl-ketone Warhead2023
- Author(s)
  Yoshio Hayashi
- Organizer
  57th International Conference on Medicinal Chemistry (RICT2023), Lille, Haut-de-France, France
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27305
[Presentation] From Solid-phase Disulfide Ligation to Thioether-mediated Sulfenylation of Tryptophan2023
- Author(s)
  Yoshio Hayashi
- Organizer
  9th Modern Solid Phase Peptide Synthesis & Its Applications Symposium (Solid Phase 2023), Queensland, Australia
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27305
[Presentation] Development of SARS coronavirus 3CL protease inhibitors with an electrophilic aryl-ketone warhead2023
- Author(s)
  Yoshio Hayashi
- Organizer
  14th AFMC International Medicinal Chemistry Symposium (AIMECS2023), Seoul, Korea
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27305
[Presentation] がん抑制遺伝子 TP53 のナンセンス変異に着目したネガマイシン誘導体の生物活性評価2023
- Author(s)
  江間文香、大村紀子、田口晃弘、濵田圭佑、井上由佳理、今野翔、高山健太郎、谷口敦彦、林良雄
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-19H03356
[Presentation] Inhibition of Myostatin by Bioadaptative Peptide-photooxygenation Catalyst Conjugate2022
- Author(s)
  Hideyuki Okamoto, Shuko Amber Murano, Kaoru Ikekawa, Masahiro Katsuyama, Sho Konno, Akihiro Taguchi, Kentaro Takayama, Atsuhiko Taniguchi, Yoshio Hayashi
- Organizer
  第59回ペプチド討論会
- Data Source
  KAKENHI-PROJECT-19H03356
[Presentation] SARS-CoV-2 3CLプロテアーゼを標的とした高選択的Activity-based probeの開発2022
- Author(s)
  山内勇輝、吉岡成美、今野翔、田口晃弘、谷口敦彦、林良雄
- Organizer
  日本ケミカルバイオロジー学会第16回年会
- Data Source
  KAKENHI-PROJECT-19H03356
[Presentation] A New Synthetic Chemistry of Cyclic Peptides for the Development of Mid-sized Peptide Drugs2022
- Author(s)
  Akihiro Taguchi, Kiyotaka Kobayashi, Yan Cui, Hayate Shida, Chihiro Uchiyama, Akane Fukuda, Kyohei Muguruma, Sho Konno, Kentaro Takayama, Atsuhiko Taniguchi, Yoshio Hayashi
- Organizer
  Frontiers in Peptide Science and Drug Discovery (FPSDD) (Nanyang Technological University, Singapore)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03356
[Presentation] トリプトファンを標的とする選択的標識法の開発2022
- Author(s)
  常田勇磨、田口晃弘、志田颯、崔岩、今野翔、谷口敦彦、林良雄
- Organizer
  第39回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-19H03356
[Presentation] Thioether-mediated Sulfenylation to the Indole Ring of Tryptophan2022
- Author(s)
  Yuma Tokita, Akihiro Taguchi, Hayate Shida, Yan Cui, Sho Konno, Atsuhiko Taniguchi, Yoshio Hayashi
- Organizer
  第59回ペプチド討論会
- Data Source
  KAKENHI-PROJECT-19H03356
[Presentation] Development of Water-soluble Npys Derivative and Application of Efficient Synthesis of Cyclic Disulfide Peptide2022
- Author(s)
  Akihiro Taguchi, Moe Sakata, Sayaka Kuraishi, Sho Konno, Kentaro Takayama, Atsuhiko Taniguchi, Yoshio Hayashi
- Organizer
  36th European Peptide Symposium/12th International Peptide Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03356
[Presentation] SARS coronavirus 3CL protease inhibitors with an electrophilic aryl-ketone warhead2022
- Author(s)
  Sho Konno, Yoshio Hayashi, et al
- Organizer
  36th European Peptide Symposium/12th International Peptide Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03356
[Presentation] Readthrough Effect of a Nonsense Mutation in P53 Tumor Suppressor Gene by Negamycin Derivatives2022
- Author(s)
  Noriko Omura, Ayaka Ema, Akihiro Taguchi, Keisuke Hamada, Sho Konno, Kentaro Takayama, Atsuhiko Taniguchi, Yoshio Hayashi
- Organizer
  第59回ペプチド討論会
- Data Source
  KAKENHI-PROJECT-19H03356
[Presentation] 3-エピデオキシネガマイシンの分子空間固定が及ぼすリードスルー活性への影響2022
- Author(s)
  大村紀子、田口晃弘、濵田圭佑、桑原智希、渡邉瑞貴、中久木正則、今野翔、高山健太郎、谷口敦彦、乃村俊史、周東智、林良雄
- Organizer
  日本ケミカルバイオロジー学会第16回年会
- Data Source
  KAKENHI-PROJECT-19H03356
[Presentation] スルフェン酸フェニルエステルに基づく活性ジスルフィド形成と人工タンパク質合成への応用2022
- Author(s)
  志田颯、崔岩、田口晃弘、今野翔、高山健太郎、谷口敦彦、林良雄
- Organizer
  第48回反応と合成の進歩シンポジウム
- Data Source
  KAKENHI-PROJECT-19H03356
[Presentation] Methionine-mediated Sulfenylation of Tryptophan In Peptide2022
- Author(s)
  Hayate Shida, Akihiro Taguchi, Yan Cui, Yuma Tokita, Reo Kishi, Sho Konno, Atsuhiko Taniguchi, Yoshio Hayashi
- Organizer
  第59回ペプチド討論会
- Data Source
  KAKENHI-PROJECT-19H03356
[Presentation] アリールケトン型SARS-CoV-2 3CLプロテアーゼ阻害剤YH-53の効率的合成法の確立2022
- Author(s)
  山内勇輝、今野翔、藤末大貴、田口晃弘、谷口敦彦、林良雄
- Organizer
  第39回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-19H03356
[Presentation] アリールケトン型阻害剤を基盤としたSARS-CoV-2の3CLプロテアーゼに対する分解誘導剤の開発2022
- Author(s)
  坂東真規、今野翔、大村紀子、中村太成、田口晃弘、谷口敦彦、林良雄
- Organizer
  日本ケミカルバイオロジー学会第16回年会
- Data Source
  KAKENHI-PROJECT-19H03356
[Presentation] SARS-CoV-2 3CLプロテアーゼを標的とした高選択的活性基盤型プローブの創製2022
- Author(s)
  林良雄、山内勇輝、吉岡成美、田口晃弘、谷口敦彦、今野翔
- Organizer
  第27回日本病態プロテアーゼ学会
- Data Source
  KAKENHI-PROJECT-19H03356
[Presentation] 水溶性Npys誘導体のジスルフィド形成反応を利用した環状ペプチドの効率的合成法の開発2022
- Author(s)
  田口晃弘、坂田萌、倉石彩恵香、今野翔、高山健太郎、谷口敦彦、林良雄
- Organizer
  第48回反応と合成の進歩シンポジウム
- Data Source
  KAKENHI-PROJECT-19H03356
[Presentation] Effect of Conformational Restriction of 3-Epi-deoxynegamycin on Readthrough Activity2022
- Author(s)
  Noriko Omura, Akihiro Taguchi, Keisuke Hamada, Tomoki Kuwahara, Mizuki Watanabe, Masanori Nakakuki, Sho Konno, Kentaro Takayama, Atsuhiko Taniguchi, Toshifumi Nomura, Satoshi Shuto, Yoshio Hayashi
- Organizer
  36th European Peptide Symposium/12th International Peptide Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03356
[Presentation] SARS-CoV-2における活性型3CLプロテアーゼ検出法の開発2022
- Author(s)
  吉岡成美、山内勇輝、大村紀子、今野翔、田口晃弘、谷口敦彦、林良雄
- Organizer
  第39回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-19H03356
[Presentation] 光酸素化触媒をコンジュゲートした all-D 体マイオスタチン阻害剤の開発2022
- Author(s)
  池川馨、岡本英之、村野周子アンバー、勝山雅大、今野翔、田口晃弘、高山健太郎、谷口敦彦、林良雄
- Organizer
  第39回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-19H03356
[Presentation] Development of Peptide-photooxygenation Catalyst Conjugates for Myostatin Inactivation2022
- Author(s)
  Hideyuki Okamoto, Atsuhiko Taniguchi, Shoya Usami, Masahiro Katsuyama, Shuko-Amber Murano, Sho Konno, Akihiro Taguchi, Kentaro Takayama, Yoshio Hayashi
- Organizer
  36th European Peptide Symposium/12th International Peptide Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03356
[Presentation] 水溶性Npys誘導体を用いたジスルフィドペプチドの効率的合成法開発2021
- Author(s)
  坂田萌、田口晃弘、倉石彩恵香、今野翔、髙山健太郎、谷口敦彦、林良雄
- Organizer
  創薬懇話会2021 in 京都
- Data Source
  KAKENHI-PROJECT-19H03356
[Presentation] 水溶性Npys誘導体の機能評価：アドレノメジュリンのワンポット合成2021
- Author(s)
  坂田萌、田口晃弘、倉石彩恵香、今野翔、髙山健太郎、谷口敦彦、林良雄
- Organizer
  日本ケミカルバイオロジー学会第15回年会
- Data Source
  KAKENHI-PROJECT-19H03356
[Presentation] マイオスタチン阻害ペプチドの創製2021
- Author(s)
  林良雄、高山健太郎、淺利知、岡本英之、根岸洋一、常陸圭介、土田邦博、伊東史子、谷口敦彦
- Organizer
  第7回日本筋学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03356
[Presentation] Modular synthesis of disulfide cross-linked HIV-1 protease analogue using 4-fluorophenyl 3-nitro-2-pyridinesulfenate (Npys-OPh(pF))2021
- Author(s)
  Y. Cui, A. Taguchi, H. Shida, K. Kobayashi, S. Konno, K. Takayama, A. Taniguchi, Y. Hayashi
- Organizer
  第58回ペプチド討論会
- Data Source
  KAKENHI-PROJECT-19H03356
[Presentation] マイオスタチンを選択的に光酸素化する短鎖化ペプチドー触媒架橋体の開発2021
- Author(s)
  村野周子アンバー、岡本英之、勝山雅大、今野翔、田口晃弘、高山健太郎、谷口敦彦、林良雄
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-19H03356
[Presentation] 水溶性Npys誘導体を用いた環状ジスルフィドペプチドのワンポット合成2021
- Author(s)
  坂田萌、田口晃弘、倉石彩恵香、今野翔、高山健太郎、谷口敦彦、林良雄
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-19H03356
[Presentation] Development of solid supported 4-fluorophenyl 3-nitro-2-pyridinesulfenate for the efficient construction of disulfide-linked hybrid molecules2021
- Author(s)
  崔岩、田口晃弘、小林清孝、志田颯、今野翔、谷口敦彦、高山健太郎、林良雄
- Organizer
  創薬懇話会2021 in 京都
- Data Source
  KAKENHI-PROJECT-19H03356
[Presentation] One-pot Disulfide-driven Cyclic Peptide Synthesis of Oxytocin Using 4-Fluorophenyl 3-Nitro-2-pyridinesulfenate (Npys-OPh(pF))2021
- Author(s)
  H. Shida, A. Taguchi, K. Kobayashi, Y. Cui, S. Konno, K. Takayama, A. Taniguchi, Y. Hayashi
- Organizer
  第58回ペプチド討論会
- Data Source
  KAKENHI-PROJECT-19H03356
[Presentation] 固相Npys化反応を鍵とするジスルフィド駆動型環状ペプチド合成法の開発2021
- Author(s)
  志田颯、田口晃弘、小林清孝、崔岩、今野翔、髙山健太郎、谷口敦彦、林良雄
- Organizer
  第47回反応と合成の進歩シンポジウム
- Data Source
  KAKENHI-PROJECT-19H03356
[Presentation] Development of Conformationally Restricted Negamycin Derivatives for Potent Readthrough Activity (Excellent Poster Presentation Award)2021
- Author(s)
  N. Omura, A. Taguchi, K. Hamada, T. Kuwahara, M. Watanabe, M. Nakakuki, S. Konno, K. Takayama, A. Taniguchi, T. Nomura, S. Shuto, Y. Hayashi
- Organizer
  第58回ペプチド討論会
- Data Source
  KAKENHI-PROJECT-19H03356
[Presentation] Modular synthesis of HIV-1 protease analogue by disulfide ligation using 4-fluorophenyl 3-nitro-2-pyridinesulfenate (Npys-OPh(pF))2021
- Author(s)
  Y. Cui, A. Taguchi, H. Shida, K. Kobayashi, S. Konno, K. Takayama, A. Taniguchi, Y. Hayashi
- Organizer
  13th AFMC International Medicinal Chemistry Symposium (AIMECS2021)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03356
[Presentation] Development of peptide-photooxygenation catalyst conjugates that efficiently oxygenate myostatin2021
- Author(s)
  H. Okamoto, A. Taniguchi, S. Usami, M. Katsuyama, S. Konno, A. Taguchi, K. Takayama, Y. Hayashi
- Organizer
  13th AFMC International Medicinal Chemistry Symposium (AIMECS2021)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03356
[Presentation] ネガマイシン３位アミノ基誘導体の創製と各種遺伝性疾患に対するリードスルー効果の検討2021
- Author(s)
  大村紀子、濵田圭佑、田口晃弘、今野翔、高山健太郎、谷口敦彦、林良雄
- Organizer
  創薬懇話会2021 in 京都
- Data Source
  KAKENHI-PROJECT-19H03356
[Presentation] 標的選択的光酸素化を用いたマイオスタチンの効率的阻害2021
- Author(s)
  谷口敦彦、岡本英之、宇佐美翔哉、勝山雅大、今野翔、田口晃弘、高山健太郎、林良雄
- Organizer
  日本ケミカルバイオロジー学会第15回年会
- Data Source
  KAKENHI-PROJECT-19H03356
[Presentation] 部位特異的抗体修飾法に応用可能な高親和性抗体結合ペプチドの創製2021
- Author(s)
  大澤錬人、六車共平、福田茜、藤田好珠、石川直到、田口晃弘、高山健太郎、谷口敦彦、伊東祐二、林良雄
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-19H03356
[Presentation] Development of new one-pot synthetic method for cyclic disulfide peptides based on 3-nitro-2-pyridinesulfenates2021
- Author(s)
  H. Shida, A. Taguchi, K. Kobayashi, Y. Cui, S. Konno, K. Takayama, A. Taniguchi, Y. Hayashi
- Organizer
  13th AFMC International Medicinal Chemistry Symposium (AIMECS2021)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03356
[Presentation] Efficient Inhibition of Myostatin Activity by Functionalized Peptides with Photooxygenation Catalyst2021
- Author(s)
  H. Okamoto, A. Taniguchi, S. Usami, M. Katsuyama, S. Konno, A. Taguchi, K. Takayama, Y. Hayashi
- Organizer
  第58回ペプチド討論会
- Data Source
  KAKENHI-PROJECT-19H03356
[Presentation] ニトロピリジンスルフェン酸エステルを用いた環状ペプチド固相合成法の開発2021
- Author(s)
  志田颯、田口晃弘、小林清孝、崔岩、今野翔、髙山健太郎、谷口敦彦、林良雄
- Organizer
  創薬懇話会2021 in 京都
- Data Source
  KAKENHI-PROJECT-19H03356
[Presentation] 分子空間固定型ネガマイシンの合成とそのリードスルー活性評価2021
- Author(s)
  大村紀子、田口晃弘、濵田圭佑、桑原智希、渡邉瑞貴、中久木正則、今野翔、高山健太郎、谷口敦彦、乃村俊史、周東智、林良雄
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-19H03356
[Presentation] Structure-Activity Relationship Study Focusing on 3-epi-Deoxynegamycin for Readthrough Activity2021
- Author(s)
  N. Omura, A. Taguchi, K. Hamada, T. Kuwahara, M. Watanabe, M. Nakakuki, S. Konno, K. Takayama, A. Taniguchi, T. Nomura, S. Shuto, Y. Hayashi
- Organizer
  13th AFMC International Medicinal Chemistry Symposium (AIMECS2021)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03356
[Presentation] Development of One-pot Synthesis of Cyclic Disulfide Peptide Using Water-soluble Npys Derivative2021
- Author(s)
  M. Sakata, A. Taguchi, S. Kuraishi, S. Konno, K. Takayama, A. Taniguchi, Y. Hayashi
- Organizer
  第58回ペプチド討論会
- Data Source
  KAKENHI-PROJECT-19H03356
[Presentation] 高活性リードスルー化合物の獲得を目指したネガマイシン誘導体５位アミノ基の誘導化2021
- Author(s)
  澤田直志、大村紀子、濵田圭佑、今野翔、田口晃弘、高山健太郎、谷口敦彦、林良雄
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-19H03356
[Presentation] 光酸素化能を付与した機能化ペプチドによるマイオスタチンの活性阻害2021
- Author(s)
  岡本英之、谷口敦彦、宇佐美翔哉、勝山雅大、今野翔、田口晃弘、高山健太郎、林良雄
- Organizer
  創薬懇話会2021 in 京都
- Data Source
  KAKENHI-PROJECT-19H03356
[Presentation] MA026の構造訂正とTJ開口活性の作用機構解析2020
- Author(s)
  南雲陽子、向山海凪、内山千尋、福田茜、有本光江、山﨑洋平、加香孝一郎、勝山陽平、谷口敦彦、林良雄、臼井健郎
- Organizer
  第62回　天然有機化合物討論会
- Data Source
  KAKENHI-PROJECT-19H03356
[Presentation] Development of Solid-Supported 4-Fluorophenyl 3-Nitro-2-Pyridinesulfenate (Npys-OPh(pF)) as An Efficient Disulfide-Forming Agent2020
- Author(s)
  Y. Cui, A. Taguchi, K. Kobayashi, H. Shida, K. Takayama, A. Taniguchi, and Y. Hayashi
- Organizer
  第57回　ペプチド討論会
- Data Source
  KAKENHI-PROJECT-19H03356
[Presentation] Development of Solid Supported Npys-OPh(pF) Agent for Efficient Solid-Phase Disulfide Ligation2020
- Author(s)
  Y. Cui, A. Taguchi, K. Kobayashi, H. Shida, K. Takayama, A. Taniguchi, and Y. Hayashi
- Organizer
  The 16th Chinese International Peptide Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03356
[Presentation] 固相ワンポットジスルフィド駆動型環状ペプチド合成法の開発2020
- Author(s)
  志田颯、田口晃弘、小林清孝、崔岩、高山健太郎、谷口敦彦、林良雄
- Organizer
  日本薬学会　第140年会
- Data Source
  KAKENHI-PROJECT-19H03356
[Presentation] 固相法を基盤とした新規環状ジスルフィドペプチド合成法の開発2020
- Author(s)
  志田颯、田口晃弘、小林清孝、崔岩、髙山健太郎、谷口敦彦、林良雄
- Organizer
  第64回　日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-19H03356
[Presentation] Structure revision of cyclic depsipeptide MA026 and structure-activity relationship study based on tight junction open activity2019
- Author(s)
  内山千尋、福田茜、向山海凪、中澤佳輝、有本光江、加香考一郎、田口晃弘、高山健太郎、谷口敦彦、南雲陽子、臼井健郎、林良雄
- Organizer
  第56回　ペプチド討論会
- Data Source
  KAKENHI-PROJECT-19H03356
[Presentation] 生体分子におけるジスルフィド結合形成を指向した水溶性Npys誘導体の創製2019
- Author(s)
  田口晃弘、倉石彩恵香、小林清孝、崔　岩、高山健太郎、谷口敦彦、林良雄
- Organizer
  日本ケミカルバイオロジー学会　第14回年会
- Data Source
  KAKENHI-PROJECT-19H03356
[Presentation] STRUCTURE-ACTIVITY RELATIONSHIP STUDY OF AN ANTIBODY- BINDING PEPTIDE FOCUSED ON GLYCINE RESIDUE AT THE POSITION 92019
- Author(s)
  A. Fukuda, K. Muguruma, R. Osawa, S. Kishimoto, A. Taguchi, K.Takayama, A. Taniguchi, Y. Ito, and Y. Hayashi
- Organizer
  第56回　ペプチド討論会
- Data Source
  KAKENHI-PROJECT-19H03356
[Presentation] 生体分子へ適用可能な水溶性Npys型ジスルフィド形成試薬の創製2019
- Author(s)
  濵田佳穂、田口晃弘、倉石彩恵香、小林清孝、崔岩、高山健太郎、谷口敦彦、林良雄
- Organizer
  第37回　メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-19H03356
[Presentation] "ON-RESIN" disulfide peptide synthesis using methyl 3-nitro-2-pyridinesulfenate2019
- Author(s)
  K. Kobayashi, A. Taguchi, K. Muguruma, K. Takayama, A. Taniguchi, and Y. Hayashi
- Organizer
  26th American Peptide Symposium and 11th International Peptide Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03356
[Presentation] MA026の構造訂正及びタイトジャンクション開口能に基づいた構造活性相関研究2019
- Author(s)
  内山千尋、福田茜、向山海凪、中澤佳輝、有本光江、加香考一郎、田口晃弘、高山健太郎、谷口敦彦、南雲陽子、臼井健郎、林良雄
- Organizer
  第37回　メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-19H03356
[Presentation] Structure-antibody binding affinity relationship study of cyclic disulfide peptides2019
- Author(s)
  K. Muguruma, K. Fujita, A. Fukuda, S. Kishimoto, R. Arima, A. Taguchi, K. Takayama, A. Taniguchi, Y. Ito, and Y. Hayashi
- Organizer
  26th American Peptide Symposium and 11th International Peptide Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03356
[Presentation] 水溶性Npys 誘導体を基盤としたジスルフィド形成試薬の創製とその機能性評価2019
- Author(s)
  田口晃弘，倉石彩恵香，小林清孝，崔岩，高山健太郎，谷口敦彦，林良雄
- Organizer
  第45回　反応と合成の進歩シンポジウム
- Data Source
  KAKENHI-PROJECT-19H03356
[Presentation] ジスルフィド駆動型環状ペプチド合成法によるヒトエンドセリン-2の合成2019
- Author(s)
  志田颯、田口晃弘、小林清孝、崔岩、高山健太郎、谷口敦彦、林良雄
- Organizer
  第37回　メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-19H03356
[Presentation] 抗体-薬物複合体への応用をめざした微小管重合阻害剤Plinabulinのジスルフィド型プロドラッグ創製研究2019
- Author(s)
  佐藤菜那、福田茜、六車共平、黒田綾、遠藤京弥、田口晃弘、高山健太郎、谷口敦彦、伊東祐二、林良雄
- Organizer
  第37回　メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-19H03356
[Presentation] Npys-OMeを用いた固相ジスルフィド架橋法による環状ペプチドの合成展開(Synthesis of cyclic peptides by on-resin disulfide bond formation via Npys-OMe)2019
- Author(s)
  小林清孝、田口晃弘、崔岩、志田颯、濵田佳穂、高山健太郎、谷口敦彦、林良雄
- Organizer
  第37回　メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-19H03356
[Presentation] Development of 4-Fluorophenyl 3-Nitro-2-Pyridinesulfenate, Npys-OPh(pF) Resin as An Efficient Disulfide-Forming Reagent2019
- Author(s)
  崔岩、田口晃弘、小林清孝、志田颯、高山健太郎、谷口敦彦、林良雄
- Organizer
  第37回　メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-19H03356
[Presentation] NPYS化学を基盤とするペプチド合成化学から創薬までの研究展開2019
- Author(s)
  林良雄、田口晃弘、六車共平、Yan Cui、小林清孝
- Organizer
  第63回　日本薬学会　関東支部大会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03356
[Presentation] タイトジャンクション開口剤MA026の構造訂正及び構造活性相関研究2019
- Author(s)
  内山千尋、福田茜、向山海凪、中澤佳輝、有本光江、加香考一郎、田口晃弘、高山健太郎、谷口敦彦、南雲陽子、臼井健郎、林良雄
- Organizer
  第63回　日本薬学会　関東支部大会
- Data Source
  KAKENHI-PROJECT-19H03356
[Presentation] Structure-activity relationship study of an antibody-binding peptide for the preparation of antibody-drug conjugate2019
- Author(s)
  K. Muguruma, K. Fujita, A. Fukuda, S. Kishimoto, R. Arima, A. Taguchi, K. Takayama, A. Taniguchi, Y. Ito, and Y. Hayashi
- Organizer
  Antibody Engineering & Therapeutics 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03356
[Presentation] Development of solid-supported 4-fluorophenyl 3-nitro-2-pyridinesulfenate agent for efficient solid-phase disulfide ligation2019
- Author(s)
  崔岩、田口晃弘、小林清孝、志田颯、高山健太郎、谷口敦彦、林良雄
- Organizer
  第63回　日本薬学会　関東支部大会
- Data Source
  KAKENHI-PROJECT-19H03356
[Presentation] Synthesis and structure-activity relationship study of an antibody-binding peptide focused on the C-terminal histidine residue2019
- Author(s)
  M. Ito, K. Muguruma, A. Fukuda, S. Kishimoto, A. Taguchi, K. Takayama, A. Taniguchi, Y. Ito, and Y. Hayashi
- Organizer
  The 27th French-Jaanese Suymposium on Medicinal and Fine Chemistry
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03356
[Presentation] Development of water-soluble Npys-OMe derivatives for the disulfide bond formation of biomolecules2019
- Author(s)
  A. Taguchi, S. Kuraishi, K. Kobayashi, Y. Cui, K. Takayama, A. Taniguchi, and Y. Hayashi
- Organizer
  The 27th French-Jaanese Suymposium on Medicinal and Fine Chemistry
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03356
[Presentation] Structure-Activity Relationship Study of Human IgG Binding Peptide Focused on Glycine Residue at the Position 92019
- Author(s)
  A. Fukuda, K. Muguruma, R. Osawa, S. Kishimoto, A. Taguchi, K.Takayama, A. Taniguchi, Y. Ito, and Y. Hayashi
- Organizer
  第37回　メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-19H03356
[Presentation] development of leucyl-3-epi-deoxynegamycin derivative with a potent readthrough activity2019
- Author(s)
  大村紀子、濵田圭佑、田口晃弘、嶋野慶樹、澤田直志、高山健太郎、谷口敦彦、林良雄
- Organizer
  第56回　ペプチド討論会
- Data Source
  KAKENHI-PROJECT-19H03356
[Presentation] A new scenario for disulfide peptide synthesis based on 3-nitro-2-pyridinesulfenates2019
- Author(s)
  Y. Hayashi, A. Taguchi
- Organizer
  The 7th Modern Solid Phase Peptide Synthesis & Its Applications Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03356
[Presentation] SAR study of negamycin derivative focused on the 3-amino position for potent readthrough activity2019
- Author(s)
  N. Omura, K. Hamada, A. Taguchi, M. Arai, K. Shimano, K. Takayama, A. Taniguchi, and Y. Hayashi
- Organizer
  26th American Peptide Symposium and 11th International Peptide Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03356
[Presentation] Structure revision and structure-activity relationship as TJ opener of MA0262019
- Author(s)
  C. Uchiyama, A. Fukuda, M. Mukaiyama, D. Nakazawa, M. Arimoto, K. Kako, A. Taguchi, K. Takayama, A. Taniguchi, Y. Nagumo, T. Usui, and Y. Hayashi
- Organizer
  The 7th Modern Solid Phase Peptide Synthesis & Its Applications Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03356
[Presentation] MA026の構造訂正とTJ開口活性に関する構造活性相関検討2019
- Author(s)
  向山海凪、山﨑洋平、内山千尋、有本光江、加香考一郎、林良雄、南雲陽子、臼井健郎
- Organizer
  日本ケミカルバイオロジー学会　第14回年会
- Data Source
  KAKENHI-PROJECT-19H03356
[Presentation] 高リードスルー活性を有するネガマイシン誘導体TCP-1109の創製とその活性評価2019
- Author(s)
  嶋野慶樹、濵田圭佑、大村紀子、田口晃弘、澤田直志、高山健太郎、谷口敦彦、林良雄
- Organizer
  第37回　メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-19H03356
[Presentation] 小型化マイオスタチン阻害ペプチドの発見と高活性誘導体の創製2018
- Author(s)
  六本木　佳美、高山　健太郎、齊藤　まりこ、中村　明里、嶋田　嵩大、田口　晃弘、谷口　敦彦、根岸　洋一、林　良雄
- Organizer
  創薬懇話会2017 in 志賀島
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] Structural requirements of mouse myostatin prodomain-derived small peptide for effective myostatin inhibition2018
- Author(s)
  K. Takayama, T. Asari, M. Saitoh, Y. Roppongi, A. Nakamura, A. T. Shimada, Taguchi, A. Taniguchi, Y. Negishi and Y. Hayashi
- Organizer
  8th Peptide Engineering Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] Structure Activity Relationship Study for Obtaining Human Neuromedin U Receptor Selective Hexapeptide Agonists2018
- Author(s)
  K. Takayama, K. Mori, E. Nomura, Y. Sohma, A. Tanaka, A. Taguchi, A. Taniguchi, T. Sakane, A. Yamamoto, N. Minamino, M. Miyazato, K. Kangawa, and Y. Hayashi
- Organizer
  XXII International Conference on Organic Synthesis; 22-ICOS
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] Structural derivatization for the effective myostatin inhibition of myostatin prodomain-derived peptide derivatives2018
- Author(s)
  K. Takayama, T. Asari, M. Saitoh, Y. Roppongi, A. Nakamura, A. Taguchi, A. Taniguchi, Y. Negishi and Y. Hayashi
- Organizer
  11th Japanese-French Workshop “New insights in personalized medicine for neuromuscular diseases: From Basic to Applied Myology”
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] Structural requirements for the effective myostatin inhibition of myostatin prodomain-derived peptide derivatives2018
- Author(s)
  K. Takayama, T. Asari, M. Saitoh, Y. Roppongi, A. Nakamura, A. Taguchi, A. Taniguchi and Y. Hayashi
- Organizer
  256th American Chemical Society National Meeting & Exposition
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] ヒト２型ニューロメジンU受容体選択的アゴニストの創製と抗肥満効果2018
- Author(s)
  高山　健太郎，森　健二，田中　晶子，石兼　真，田口　晃弘，谷口　敦彦，坂根　稔康，山本　昌，南野　直人，宮里　幹也，寒川　賢治，林　良雄
- Organizer
  第91回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] マイオスタチン阻害ペプチドの小型化と構造活性相関研究2018
- Author(s)
  高山　健太郎、淺利　知、齋藤　まりこ、六本木　佳美、中村　明里、佐賀　裕介、嶋田　嵩大、池山　弘晃、田口　晃弘、谷口　敦彦、根岸　洋一、林　良雄
- Organizer
  日本筋学会第4回学術集会
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] 網羅的構造活性相関研究によるマウス由来マイオスタチン阻害ペプチドの高活性化2018
- Author(s)
  高山　健太郎，淺利　知，齋藤　まりこ，六本木　佳美，中村　明里，嶋田　嵩大，池山　弘晃，田口　晃弘，谷口　敦彦，根岸　洋一，林　良雄
- Organizer
  第36回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] 小型化マイオスタチン阻害ペプチドの発見と高活性化2018
- Author(s)
  齊藤　まりこ、高山　健太郎、C. Rentier、中村　明里、嶋田　嵩大、六本木　佳美、田口　晃弘、谷口　敦彦、根岸　洋一、林良雄
- Organizer
  日本薬学会第 138 年会
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] Discovery of Selective Hexapeptidic Agonists to Human NMUR1 and NMUR22018
- Author(s)
  K. Takayama, K. Mori, A. Tanaka, Y. Sohma, E. Nomura, A. Taguchi, A. Taniguchi, T. Sakane, A. Yamamoto, N. Minamino, M. Miyazato, K. Kangawa, Y. Hayashi
- Organizer
  54th International Conference on Medicinal Chemistry (RICT2018)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] Structure-Activity Relationship Study of Anti-microtubule Agent based on KPU-300 Structur2017
- Author(s)
  R. Kuboki, Y. Hayashi, C. Sakuma, M. Kobayashi, T. Chinen, A. Taguchi, K. Takayama, A. Taniguchi, T. Usui, Y. Hayashi
- Organizer
  21st Korean Peptide Protein Society Symposium(21st KPPS)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15145
[Presentation] ヒトニューロメジンU受容体の各サブタイプに選択的なペプチドアゴニストの創製2017
- Author(s)
  高山　健太郎，森　健二，武田　康嗣，相馬　悠子，野村　恵梨奈，田口　晃弘，谷口　敦彦，南野　直人，宮里　幹也，寒川　賢治，林　良雄
- Organizer
  第14回GPCR研究会
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] DISCOVERY OF SELECTIVE HEXAPEPTIDE AGONISTS TOWARD HUMAN NMUR12017
- Author(s)
  K. Takayama, K. Mori, E. Nomura, Y. Sohma, A. Tanaka, A. Taguchi, A. Taniguchi, T. Sakane, A. Yamamoto, N. Minamino, M. Miyazato, K. Kangawa, and Y. Hayashi
- Organizer
  第 54 回ペプチド討論会
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] 微小管重合阻害剤KPU-300を基盤とした構造活性相関研究2017
- Author(s)
  林良樹，久保木里衣，佐久間千尋，中澤大輝，六車共平，知念拓実，田口晃弘，高山健太郎，薬師寺文華，谷口敦彦，臼井健郎，林良雄
- Organizer
  第35回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-16K15145
[Presentation] Transnasal delivery of the peptide to the brain2017
- Author(s)
  A. Tanaka, C. Maeda, M. Amano, K. Takayama, Y. Hayashi, D. Inoue, T. Furubayashi, K. Kusamori, H. Katsumi, T. Sakane, A. Yamamoto
- Organizer
  6th Pharmaceutical Sciences World Congress 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] マイオスタチン阻害ペプチドの活性強化を目指した網羅的構造活性相関研究2017
- Author(s)
  高山　健太郎、池山　弘晃、C. Rentier、中村　明里、佐賀　裕介、嶋田　嵩大、齋藤　まりこ、田口　晃弘、谷口　敦彦、根岸　洋一、林　良雄
- Organizer
  第61回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] Structure-Activity Relationship Study of Anti-Microtubule Agent KPU-300 and Improvement of Its Solubility2017
- Author(s)
  Y. Hayashi, R. Kuboki, C. Sakuma, T. Chinen, A. Taguchi, K. Takayama, A. Taniguchi, T. Usui, Y. Hayashi
- Organizer
  The EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry (EFMC-ASMC’17)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15145
[Presentation] Discovery of Selective Hexapeptide Agonists to Human NMUR1 and NMUR22017
- Author(s)
  K. Takayama, K. Mori, A. Tanaka, A. Taguchi, A. Taniguchi, T. Sakane, A. Yamamoto, N. Minamino, M. Miyazato, K. Kangawa, and Y. Hayashi
- Organizer
  12th Annual Peptide Therapeutics Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] マイオスタチン阻害ペプチドの活性強化を指向した構造活性相関研究2017
- Author(s)
  六本木　佳美、高山　健太郎、C. Rentier、中村　明里、佐賀　裕介、嶋田　嵩大、齋藤　まりこ、田口　晃弘、谷口　敦彦、根岸　洋一、林　良雄
- Organizer
  日本ケミカルバイオロジー学会第１２回年会
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] Mouse Myostatin Prodomain-derived Inhibitory Peptides for Treatment of Muscle Atrophic Disorders2017
- Author(s)
  C. Rentier, M. Saitoh, A. Nakamura, T. Shimada, S. Sashida, K. Takayama, Y. Negishi and Y. Hayashi
- Organizer
  25th American Peptide Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] KPU-300を基盤とした微小管重合阻害剤の構造活性相関研究2017
- Author(s)
  久保木　里衣、林　良樹、中澤　大樹、知念　拓実、田口　晃弘、谷口　敦彦、高山　健太郎、臼井　健郎、林　良雄
- Organizer
  日本薬学会第 137 年会
- Place of Presentation
  東北大学川内キャンパス、仙台
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-16K15145
[Presentation] Mouse Myostatin Prodomain-derived Inhibitory Peptides for Treatment of Muscle Atrophic Disorders2017
- Author(s)
  C. Rentier, M. Saitoh, A. Nakamura, T. Shimada, S. Sashida, K. Takayama, Y. Negishi and Y. Hayashi
- Organizer
  25th American Peptide Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16F16413
[Presentation] マイオスタチン阻害ペプチドの活性強化を目指した構造活性相関研究2017
- Author(s)
  高山健太郎、C. Rentier、淺利知、中村明里、佐賀裕介、嶋田嵩大、齋藤まりこ、六本木佳美、田口晃弘、谷口敦彦、根岸洋一、林良雄
- Organizer
  日本筋学会第3回学術集会
- Data Source
  KAKENHI-PROJECT-16F16413
[Presentation] ヒトニューロメジンU受容体の各サブタイプに選択的なヘキサペプチドアゴニストの創製2017
- Author(s)
  高山　健太郎，森　健二，武田　康嗣，相馬　悠子，野村　恵梨奈，田口　晃弘，谷口　敦彦，南野　直人，宮里　幹也，寒川　賢治，林　良雄
- Organizer
  第90回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] Solid-phase assisted synthesis of hydrophobic plinabulin-hydrophilic peptide conjugate2017
- Author(s)
  T. Shirasaka, K. Muguruma D. Akiyama, A. Taguchi, K. Takayama, A. Taniguchi, Y. Hayashi
- Organizer
  21st Korean Peptide Protein Society Symposium(21st KPPS)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15145
[Presentation] ヒト１型ニューロメジンU受容体に対する選択的ペプチドアゴニストの創製2017
- Author(s)
  野村　恵梨奈、高山　健太郎、森　健二、相馬　悠子、田口　晃弘、谷口　敦彦、南野　直人、宮里　幹也、寒川　賢治、林　良雄
- Organizer
  日本薬学会第 137 年会
- Place of Presentation
  宮城県仙台市、仙台国際センターおよび東北大学川内キャンパス
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] ヒトNMU受容体の各サブタイプに選択的なヘキサペプチドアゴニストの創製2017
- Author(s)
  高山　健太郎，森　健二，武田　康嗣，相馬　悠子，野村　恵梨奈，田口　晃弘，谷口　敦彦，南野　直人，宮里　幹也，寒川　賢治，林　良雄
- Organizer
  日本ケミカルバイオロジー学会第１２回年会
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] 固相担持型ジスルフィド化試薬を応用したPlinabulinプロドラッグの創製研究2017
- Author(s)
  白坂　拓也、六車　共平、秋山　大地、田口　晃弘、高山　健太郎、谷口　敦彦、林　良雄
- Organizer
  創薬懇話会2017 in 加賀
- Data Source
  KAKENHI-PROJECT-16K15145
[Presentation] Discovery of Selective Hexapeptide Agonists Toward Human NMUR1 and NMUR22017
- Author(s)
  K. Takayama, K. Mori, K. Taketa, Y. Sohma, E. Nomura, A. Tanaka, A. Taguchi, A. Taniguchi, T. Sakane, A. Yamamoto, N. Minamino, M. Miyazato, K. Kangawa, and Y. Hayashi
- Organizer
  The EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry (EFMC-ASMC’17)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] マイオスタチン阻害ペプチドの活性強化を目指した構造活性相関研究2017
- Author(s)
  高山　健太郎、C. Rentier、淺利　知、中村　明里、佐賀　裕介、嶋田　嵩大、齋藤　まりこ、六本木　佳美、田口　晃弘、谷口　敦彦、根岸　洋一、林　良雄
- Organizer
  日本筋学会第3回学術集会
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] ジケトピペラジン型微小管重合阻害剤KPU-300の構造活性相関研究2017
- Author(s)
  久保木　里衣、林　良樹、佐久間　千尋、中澤　大輝、知念　拓実、田口　晃弘、高山　健太郎、谷口　敦彦、臼井　健郎、林　良雄
- Organizer
  創薬懇話会2017 in 加賀
- Data Source
  KAKENHI-PROJECT-16K15145
[Presentation] DESIGN AND SYNTHESIS OF POTENT MYOSTATIN INHIBITORY PEPTIDES2017
- Author(s)
  C. Rentier, K. Takayama, A. Nakamura, M. Saitoh, S. Sashida, Y. Negishi and Y. Hayashi
- Organizer
  第 54 回ペプチド討論会
- Data Source
  KAKENHI-PROJECT-16F16413
[Presentation] マイオスタチン阻害ペプチドの活性強化を指向した構造活性相関研究2017
- Author(s)
  六本木佳美、高山健太郎、C. Rentier、中村明里、佐賀裕介、嶋田嵩大、齋藤まりこ、田口晃弘、谷口敦彦、根岸洋一、林良雄
- Organizer
  日本ケミカルバイオロジー学会第１２回年会
- Data Source
  KAKENHI-PROJECT-16F16413
[Presentation] Optimization of myostatin inhibiting peptides incorporating multiple modifications for the improvement of inhibitory activity2016
- Author(s)
  Rentier, C., Nakamura, A., Takayama, K., Saga, Y., Shimada, T., Sashida, S., Taguchi, A., Negishi Y. and Hayashi, Y.
- Organizer
  第 53 回ペプチド討論会
- Place of Presentation
  京都テルサ、京都
- Year and Date
  2016-10-26
- Data Source
  KAKENHI-PROJECT-16F16413
[Presentation] マウス由来最小マイオスタチン機能阻害ペプチドN末端部の構造活性相関2016
- Author(s)
  高山　健太郎、中村　明里、レンティール　セドリック、佐賀　裕介、嶋田　嵩大、田口　晃弘、根岸　洋一、林　良雄
- Organizer
  第二回日本筋学会学術集会
- Place of Presentation
  東京都小平市、国立研究開発法人国立精神・神経医療研究センター
- Year and Date
  2016-08-05
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] マイオスタチン阻害ペプチドのN末端トリプトファン残基に着目した構造活性相関研究2016
- Author(s)
  佐賀　裕介，高山　健太郎，三野　友作，中村　明里，淺利　知，田口　晃弘，薬師寺　文華，林　良雄
- Organizer
  日本薬学会第 136 年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] マイオスタチン阻害ペプチドの二次構造に着目した構造活性相関研究2016
- Author(s)
  嶋田　嵩大、高山　健太郎、三野　友作、中村　明里、淺利　知、佐賀　裕介、齊藤　まりこ、六本木　佳美、田口　晃弘、林　良雄
- Organizer
  第 60 回日本薬学会関東支部大会
- Place of Presentation
  東京都文京区、東京大学大学院薬学系研究科山上会館
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] Discovery of mouse-derived human myostatin-inhibitory peptides and its N-terminal acylation2016
- Author(s)
  Kentaro Takayama, Akari Nakamura, Yusaku Mino, Tomo Asari, Yusuke Saga, Akihiro Taguchi, and Yoshio Hayashi
- Organizer
  The XXIV EFMC International Symposium on Medicinal Chemistry (EFMC-ISMC 2016)
- Place of Presentation
  Manchester Central Convention Complex, Manchester, UK
- Year and Date
  2016-08-28
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] Discovery of human NMUR2 selective hexapeptidic agonists2016
- Author(s)
  Koji Taketa, Kentaro Takayama, Kenji Mori, Yuko Sohma, Akihiro Taguchi, Naoto Minamino, Mikiya Miyazato, Kenji Kangawa, Yoshio Hayashi
- Organizer
  252nd American Chemical Society National Meeting & Exposition
- Place of Presentation
  Philadelphia Convention Center, Philadelphia, PA, USA
- Year and Date
  2016-08-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] Structural basis for the effective myostatin inhibitory activity of the minimum peptide derived from mouse myostatin prodomain2016
- Author(s)
  Kentaro Takayama, Tomo Asari, Akari Nakamura, Yusuke Saga, Takahiro Shimada, Akihiro Taguchi, Yoshio Hayashi
- Organizer
  第 53 回ペプチド討論会
- Place of Presentation
  京都府京都市、京都テルサ
- Year and Date
  2016-10-26
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] ヒトNMUR2選択的に作用するヘキサペプチドアゴニストの創製2016
- Author(s)
  武田　康嗣、高山　健太郎、相馬　悠子、森　健二、田口　晃弘、南野　直人、宮里　幹也、寒川　賢治、林　良雄
- Organizer
  創薬懇話会2016 in 蓼科
- Place of Presentation
  長野県茅野市、エクシブ蓼科
- Year and Date
  2016-06-30
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] Structural basis for the effective myostatin inhibitory activity of the minimum peptide originated from mouse myostatin prodomain2016
- Author(s)
  Kentaro Takayama, Tomo Asari, Akari Nakamura, Yusuke Saga, Takahiro Shimada, Akihiro Taguchi, and Yoshio Hayashi
- Organizer
  2016 ASCB Annual Meeting
- Place of Presentation
  Moscone Center, San Francisco, CA, USA
- Year and Date
  2016-12-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] マウス由来最小マイオスタチン阻害ペプチドを基盤とする網羅的構造活性相関研究2016
- Author(s)
  高山　健太郎、淺利　知、中村　明里、佐賀　裕介、嶋田　嵩大、田口　晃弘、林　良雄
- Organizer
  第34回メディシナルケミストリーシンポジウム
- Place of Presentation
  茨城県つくば市、つくば国際会議場
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] マウス由来マイオスタチン機能阻害ペプチドの発見と構造活性相関2016
- Author(s)
  高山　健太郎、中村　明里、レンティール　セドリック、佐賀　裕介、嶋田　嵩大、田口　晃弘、林　良雄
- Organizer
  日本ケミカルバイオロジー学会第１１回年会
- Place of Presentation
  京都府京都市、京都テルサ
- Year and Date
  2016-06-15
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] Discovery of hexapeptide agonists toward human NMUR1 and NMUR2 and their metabolism in serum2016
- Author(s)
  Kentaro Takayama, Kenji Mori, Koji Taketa, Yuko Sohma, Akihiro Taguchi, Fumika Yakushiji, Naoto Minamino, Mikiya Miyazato, Kenji Kangawa, Yoshio Hayashi
- Organizer
  The 8th Takeda Science Foundation Symposium on PharmaSciences
- Place of Presentation
  Osaka, Japan
- Year and Date
  2016-01-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] マイオスタチン阻害ペプチドのN末端Trp残基に着目した構造活性相関研究2016
- Author(s)
  中村　明里、高山　健太郎、佐賀　裕介、嶋田　嵩大、田口　晃弘、林　良雄
- Organizer
  創薬懇話会2016 in 蓼科
- Place of Presentation
  長野県茅野市、エクシブ蓼科
- Year and Date
  2016-06-30
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] Transnasal delivery of peptide agonist specific to neuromedin U receptor 2 to the brain for the treatment of obesity2016
- Author(s)
  A. Tanaka, Y. Takemura, D. Inoue, T. Furubayashi, K. Taketa, K. Takayama, Y. Hayashi, K. Kusamori, H. Katsumi, T. Sakane, A. Yamamoto
- Organizer
  2016 Annual Meeting and Exposition of Controlled Release Society
- Place of Presentation
  Washington State Convention Center, Seattle, WA, USA
- Year and Date
  2016-07-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] 鼻腔内投与による生理活性ペプチドCPN-116の脳内送達2016
- Author(s)
  竹村　有希、田中　晶子、武田　康嗣、高山　健太郎、井上　大輔、古林　呂之、草森　浩輔、勝見　英正、坂根　稔康、林　良雄、山本　昌
- Organizer
  第32会DDS学会学術集会
- Place of Presentation
  静岡県静岡市、静岡県コンベンションセンター
- Year and Date
  2016-06-30
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] ジケトピペラジン型有糸分裂阻害剤KPU-300の構造活性相関研究2016
- Author(s)
  林　良樹、六車　共平、臼井　健郎、林　良雄
- Organizer
  第20回日本がん分子標的治療学会学術集会
- Place of Presentation
  別府国際コンベンションセンター、大分
- Year and Date
  2016-05-30
- Data Source
  KAKENHI-PROJECT-16K15145
[Presentation] Optimization of myostatin inhibiting peptides incorporating multiple modifications for the improvement of inhibitory activity2016
- Author(s)
  Cedric Rentier, Akari Nakamura, Kentaro Takayama, Yusuke Saga, Takahiro Shimada, Sanae Sashida, Akihiro Taguchi, Yoichi Negishi, Yoshio Hayashi
- Organizer
  第 53 回ペプチド討論会
- Place of Presentation
  京都府京都市、京都テルサ
- Year and Date
  2016-10-26
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] Structure-Activity Relationship Studies Focused on 3-Amino Moiety of Negamycin Derivatives for Potent Readthrough Activity2015
- Author(s)
  Akihiro Taguchi, Keisuke Hamada, Masaya Kotake, Suguru Aita, Saori Murakami, Kentaro Takayama, Fumika Yakushiji, Yoshio Hayashi
- Organizer
  Frontiers in Medicinal Chemistry 2015
- Place of Presentation
  Belgium
- Year and Date
  2015-09-14
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-26102740
[Presentation] ヒト１型ニューロメジンU 受容体に対する高活性ヘキサペプチドアゴニストの創製と血清中代謝解析2015
- Author(s)
  高山　健太郎、森　健二、相馬　悠子、武田　康嗣、田口　晃弘、薬師寺　文華、南野　直人、宮里　幹也、寒川　賢治、林　良雄
- Organizer
  第33回メディシナルケミストリーシンポジウム
- Place of Presentation
  千葉
- Year and Date
  2015-11-25
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] Medicinal Chemistry of Mid-sized Peptide Molecules toward the Treatment of Cancer, Muscle Disease and Obesity2015
- Author(s)
  Yoshio Hayashi
- Organizer
  IUPAC-2015
- Place of Presentation
  Busan, South Korea
- Year and Date
  2015-08-06
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] Discovery of hexapeptide agonists to human NMUR1 and NMUR22015
- Author(s)
  Kentaro Takayama, Kenji Mori, Koji Taketa, Yuko Sohma, Akihiro Taguchi, Fumika Yakushiji, Naoto Minamino, Mikiya Miyazato, Kenji Kangawa, Yoshio Hayashi
- Organizer
  Frontiers in Medicinal Chemistry 2015
- Place of Presentation
  Antwerp, Belgium
- Year and Date
  2015-09-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] Structure-activity relationship study of N-terminal Trp residue in prodomain-derived myostatin inhibitory peptide2015
- Author(s)
  Akari Nakamura, Kentaro Takayama, Yusaku Mino, Tomo Asari, Yusuke Saga, Akihiro Taguchi, Fumika Yakushiji, Yoshio Hayashi
- Organizer
  The 7th International Peptide Sympodium
- Place of Presentation
  Matrix Biopolis, Singapore
- Year and Date
  2015-12-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] ニューロメジンU受容体1型及び2型に対する選択的ヘキサペプチドアゴニストの創製2015
- Author(s)
  高山　健太郎、森　健二、武田　康嗣、相馬　悠子、田口　晃弘、薬師寺　文華、南野　直人、宮里　幹也、寒川　賢治、林　良雄
- Organizer
  第 12 回 GPCR 研究会
- Place of Presentation
  東京
- Year and Date
  2015-05-15
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] マイオスタチン阻害ペプチドのN末端アシル化と構造活性相関2015
- Author(s)
  中村　明里，高山　健太郎，三野　友作，淺利　知，佐賀　裕介，田口　晃弘，薬師寺　文華，林　良雄
- Organizer
  第33回メディシナルケミストリーシンポジウム
- Place of Presentation
  千葉
- Year and Date
  2015-11-25
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] 3位アミノ基部に着目した新規ネガマイシン誘導体の合成とそのリードスルー活性評価2015
- Author(s)
  濵田圭佑、田口晃弘、小竹優也、生澤俊太郎、会田　俊、高山健太郎、薬師寺文華、臼井健郎、林　良雄
- Organizer
  創薬懇話会2015 in Tokushima
- Place of Presentation
  徳島
- Year and Date
  2015-07-02
- Data Source
  KAKENHI-PUBLICLY-26102740
[Presentation] Discovery of hexapeptide agonists to human neuromedin U receptors 1 and 22015
- Author(s)
  Kentaro Takayama, Koji Taketa, Yuko Sohma, Akihiro Taguchi, Fumika Yakushiji, Yoshio Hayashi
- Organizer
  10th AFMC International Medicinal Chemistry Symposium (AIMECS15)
- Place of Presentation
  Jeju, South Korea
- Year and Date
  2015-10-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] ネガマイシン誘導体3位アミノ基部の修飾による高活性リードスルー化合物の創製2015
- Author(s)
  林　良雄
- Organizer
  新学術領域研究「天然物ケミカルバイオロジー～分子標的と活性制御～」第8回公開シンポジウム
- Place of Presentation
  仙台
- Year and Date
  2015-06-08
- Data Source
  KAKENHI-PUBLICLY-26102740
[Presentation] Development of (+)-Negamycin Derivatives at the C-Terminal Part as Potent Readthrough Drug Candidates2015
- Author(s)
  濵田圭佑、田口晃弘、小竹優也、会田　俊、村上沙織、高山健太郎、薬師寺文華、林　良雄
- Organizer
  第52回ペプチド討論会
- Place of Presentation
  平塚
- Year and Date
  2015-11-16
- Data Source
  KAKENHI-PUBLICLY-26102740
[Presentation] Medicinal Chemistry of Peptidic Compounds for the Treatment of Muscular Diseases2015
- Author(s)
  Kentaro Takayama, Akihiro Taguchi, Keisuke Hamada, Fumika Yakushiji, Yoshio Hayashi
- Organizer
  24th American Peptide Symposium
- Place of Presentation
  Orlando, USA
- Year and Date
  2015-06-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] Brachytherapy using Au-198 grains for oral or oropharyngeal carcinomas in patients with past histories of cancer treatments in those regions.2015
- Author(s)
  吉村亮一、三浦雅彦、渡邊裕、林敬二、中川恵子、戸田一真、戒田篤志、桑原博文、渋谷均
- Organizer
  日本放射線腫瘍学会第28回学術大会
- Place of Presentation
  ベイシア文化ホール（　群馬県、前橋市）
- Year and Date
  2015-11-19
- Data Source
  KAKENHI-PROJECT-26293399
[Presentation] 口腔癌に対するTS-1を用いた導入化学療法併用低線量率小腺源治療の安全性について2015
- Author(s)
  吉村亮一、三浦雅彦、中川恵子、渡邊裕、戒田篤志、後藤達明、桑原宏文、長野拓也、林啓二、戸田一真
- Organizer
  日本放射線腫瘍学会第17回小腺源治療部会
- Place of Presentation
  大宮ソニックシティービル（　埼玉県、さいたま市）
- Year and Date
  2015-06-26
- Data Source
  KAKENHI-PROJECT-26293399
[Presentation] ヒトNMU受容体を強力に活性化するヘキサペプチドアゴニストの創製と血清中代謝解析2015
- Author(s)
  相馬　悠子、高山　健太郎、森　健二、武田　康嗣、田口　晃弘，薬師寺　文華，南野　直人，宮里　幹也，寒川　賢治，林　良雄
- Organizer
  第52回ペプチド討論会
- Place of Presentation
  平塚、神奈川
- Year and Date
  2015-11-16
- Data Source
  KAKENHI-PROJECT-15H04658
[Presentation] ピリジンおよびベンゾフェノン構造を有する環状ジデヒドロジペプチド型新規微小管脱重合剤の創製2014
- Author(s)
  林　良樹
- Organizer
  第 51 回ペプチド討論会
- Place of Presentation
  徳島
- Year and Date
  2014-10-22
- Data Source
  KAKENHI-PROJECT-23390029
[Presentation] Development of Didehydrocyclic Dipeptide-type Anti-Microtubule Agents with a 2-Pyridine Ring2014
- Author(s)
  Yoshiki Hayashi
- Organizer
  33rd European Peptide Symposium
- Place of Presentation
  Sofia, Bulgaria
- Year and Date
  2014-08-31
- Data Source
  KAKENHI-PROJECT-23390029
[Presentation] エステル型ネガマイシン誘導体の合成とそのリードスルー活性評価2014
- Author(s)
  会田　俊、濵田圭佑、小竹優也、生澤俊太郎、塩塚政孝、野々村禎昭、田口晃弘、高山健太郎、薬師寺文華、臼井健郎、松田良一、林　良雄
- Organizer
  第58回日本薬学会関東支部大会
- Place of Presentation
  東京
- Year and Date
  2014-10-04
- Data Source
  KAKENHI-PUBLICLY-26102740
[Presentation] 2-ピリジル環を有する新規ベンゾフェノン–ジケトピペラジン型微小管重合阻害剤の創製2014
- Author(s)
  林　良樹
- Organizer
  創薬懇話会2014
- Place of Presentation
  岐阜
- Year and Date
  2014-07-10
- Data Source
  KAKENHI-PROJECT-23390029
[Presentation] 微小管を標的とした新規ジケトピペラジン型有糸分裂阻害剤の創製2014
- Author(s)
  林　良樹
- Organizer
  第18回日本がん分子標的治療学会学術集会
- Place of Presentation
  仙台
- Year and Date
  2014-06-25
- Data Source
  KAKENHI-PROJECT-23390029
[Presentation] トリペプチド型SARSコロナウイルス3CLプロテアーゼ阻害剤の開発-P4部位における構造活性相関研究-2012
- Author(s)
  山本剛史、林良雄, 他10名
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Year and Date
  2012-03-29
- Data Source
  KAKENHI-PROJECT-23390029
[Presentation] SH基選択的固相担持型ビオチニル化試薬の合成と低分子化合物の効率的ビオチン標識2012
- Author(s)
  足立　久美、林　良雄他４名
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23659059
[Presentation] クリックケミストリーを用いたチューブリン重合阻害剤Plinabulinの水溶性プロドラッグ合成研究2012
- Author(s)
  田中達也、林良雄, 他4名
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Year and Date
  2012-03-29
- Data Source
  KAKENHI-PROJECT-23390029
[Presentation] ベンゾフェノン構造を有するジケトピペラジン型微小管作用薬の構造活性相関研究2012
- Author(s)
  山崎有理, 林良雄, 他8名
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Year and Date
  2012-03-31
- Data Source
  KAKENHI-PROJECT-23390029
[Presentation] トリペプチド型SARS コロナウイルス 3CL プロテアーゼ阻害剤の開発－ P4 部位における構造活性相関研究－2012
- Author(s)
  山本　剛史、林　良雄他１０名
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23659059
[Presentation] Plinabulinの水溶性プロドラッグ合成研究:水溶性置換基の寄与について2012
- Author(s)
  六車共平、林良雄, 他3名
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Year and Date
  2012-03-30
- Data Source
  KAKENHI-PROJECT-23390029
[Presentation] 微小管作用薬Plinabulinの光親和性ビオチン化プローブの開発とそれらを利用した結合様式解析2012
- Author(s)
  山崎有理、林良雄, 他6名
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Year and Date
  2012-03-31
- Data Source
  KAKENHI-PROJECT-23390029
[Presentation] Synthesis and Structure Activity Relationship Study of Didehydro-derivatives of a Natural Diketopiperazine Tryprostatin2011
- Author(s)
  Yuki Shinozaki, Yoshio Hayashi, 他4人
- Organizer
  22nd American Peptide Symposium
- Place of Presentation
  San Diego, USA
- Year and Date
  2011-06-29
- Data Source
  KAKENHI-PROJECT-23390029
[Presentation] SARS-コロナウイルス3CLプロテアーゼ阻害剤のP4位における構造活性相関2011
- Author(s)
  仲田聖彦、林良雄, 他8名
- Organizer
  第16回日本病態プロテアーゼ学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2011-08-26
- Data Source
  KAKENHI-PROJECT-23390029
[Presentation] Synthesis and Biological Evaluation of Didehydro-type Tryprostatin B Derivatives2011
- Author(s)
  Yuki Shinozaki, Yoshio Hayash, 他4人
- Organizer
  8th AFMC International Medicinal Chemistry Symposium
- Place of Presentation
  東京
- Year and Date
  2011-12-01
- Data Source
  KAKENHI-PROJECT-23390029
[Presentation] Development of readthough peptides from dipeptidic antibiotics (+)-negamycin for Duchenne muscular dystrophy chemotherapy2011
- Author(s)
  Yoshio Hayashi, 他9人
- Organizer
  22nd American Peptide Symposium
- Place of Presentation
  San Diego, USA
- Year and Date
  2011-06-29
- Data Source
  KAKENHI-PROJECT-23390029
[Presentation] 微小管作用薬Plinabulinのケミカルプローブの開発とそれらを利用した結合様式解析2011
- Author(s)
  山崎有理、林良雄, 他6人
- Organizer
  日本ケミカルバイオロジー学会第6回年会
- Place of Presentation
  東京
- Year and Date
  2011-05-24
- Data Source
  KAKENHI-PROJECT-23390029
[Presentation] 天然由来ペプチド様小分子に基づく難病治療薬の創製研究2011
- Author(s)
  林良雄
- Organizer
  CBI学会第318回研究講演会
- Place of Presentation
  東京
- Year and Date
  2011-07-05
- Data Source
  KAKENHI-PROJECT-23390029
[Presentation] Medicinal chemistry of small peptidic natural products against intractable diseases2011
- Author(s)
  林良雄
- Organizer
  The East Japan Scripps Biomedical Forum 2011
- Place of Presentation
  東京
- Year and Date
  2011-12-03
- Data Source
  KAKENHI-PROJECT-23390029
[Presentation] ジケトピペラジン型微小管重合阻害剤Plinabulinの水溶性プロドラッグ開発研究2011
- Author(s)
  薬師寺文華、山崎有理、林良雄
- Organizer
  第15回日本がん分子標的治療学会学術集会
- Place of Presentation
  東京
- Year and Date
  2011-06-23
- Data Source
  KAKENHI-PROJECT-23390029
[Presentation] Development of SARS Coronavirus 3CL Protease Inhibitors with an Electrophilic Aryl Ketone Structure2011
- Author(s)
  Sho Konno, Yoshio Hayashi, 他10人
- Organizer
  8th AFMC International Medicinal Chemistry Symposium
- Place of Presentation
  東京
- Year and Date
  2011-12-01
- Data Source
  KAKENHI-PROJECT-23390029
[Presentation] "Plinabulin" a Vascular Targeting Anti-cancer Agent Derived from Natural Diketopiperazine "Phenylahistin/Halimide2011
- Author(s)
  Yoshio Hayashi
- Organizer
  BIT'S 1st Annual World Congress of Marine Biotechnology
- Place of Presentation
  Dalian, China
- Year and Date
  2011-04-28
- Data Source
  KAKENHI-PROJECT-23390029
[Presentation] Development of biotin-tagged plinabulin chemical probes towards the elucidation of binding mechanism of a diketopiperazine based anti-microtubule agent2011
- Author(s)
  Yuri Yamazaki, Yoshio Hayashi, 他6人
- Organizer
  22nd American Peptide Symposium
- Place of Presentation
  San Diego, USA
- Year and Date
  2011-06-29
- Data Source
  KAKENHI-PROJECT-23390029
[Presentation] Development of SARS Coronavirus 3CL Protease Inhibitors with an Electrophilic Aryl Ketone Structure2011
- Author(s)
  Sho Konno, Yoshio Hayashi 他１０人
- Organizer
  8th AFMC International Medicinal Chemistry Symposium
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23659059
[Presentation] DESIGN, SYNTHESIS, AND EVALUATION OF TRIPEPTIDEMIMETICS WITH ARYLKETONE AS INHIBITORS OF SARS-COV 3CL PROTEASE2011
- Author(s)
  Sho Konno, Yoshio Hayashi 他11名
- Organizer
  第48回ペプチド討論会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23659059
[Presentation] SARS-コロナウイルス３CLプロテアーゼ阻害剤のP４位における構造活性相関2011
- Author(s)
  仲田　聖彦、林　良雄他８名
- Organizer
  第16回日本病態プロテアーゼ学会学術集会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-23659059
[Presentation] 固相担持型SH基選択的ビオチン標識試薬の合成と低分子化合物への効率的ビオチン標識2011
- Author(s)
  福元　謙太郎、林　良雄他４人
- Organizer
  日本ケミカルバイオロジー学会第6回年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23659059
[Presentation] デュシェンヌ型ジストロフィー治療薬を目指した高リードスルー活性を有するネガマイシン誘導体研究2011
- Author(s)
  田口晃弘、林良雄, 他4名
- Organizer
  第48回ペプチド討論会
- Place of Presentation
  札幌
- Year and Date
  2011-09-27
- Data Source
  KAKENHI-PROJECT-23390029
[Presentation] Development of Readthrough Peptidemimetics from Dipeptidic Antibiotics (+)-Negamycin for Duchenne Muscular Dystrophy Chemotherapy2011
- Author(s)
  Akihiro Taguchi, Yoshio Hayashi, 他7人
- Organizer
  8th AFMC International Medicinal Chemistry Symposium
- Place of Presentation
  東京
- Year and Date
  2011-12-01
- Data Source
  KAKENHI-PROJECT-23390029
[Presentation] ジケトピペラジン型微小管重合阻害剤'Plinabulin'の水溶性プロドラッグ合成研究2011
- Author(s)
  薬師寺文華, 林良雄, 他4名
- Organizer
  第31回反応と合成の進歩シンポジウム
- Place of Presentation
  徳島
- Year and Date
  2011-11-08
- Data Source
  KAKENHI-PROJECT-23390029
[Presentation] Medicinal chemistry of small peptidic natural products against intractable diseases2011
- Author(s)
  Yoshio Hayashi, Fumika Yakushiji, 他4人
- Organizer
  8th AFMC International Medicinal Chemistry Symposium
- Place of Presentation
  東京
- Year and Date
  2011-12-02
- Data Source
  KAKENHI-PROJECT-23390029
[Presentation] A new solid-support SH specific biotinylation reagent for the efficient biotin-labeling of small molecules2011
- Author(s)
  Yoshio Hayashi, Fumika Yakushiji 他４人
- Organizer
  22nd American Peptide Symposium
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-23659059
[Presentation] DESIGN, SYNTHESIS, AND EVALUATION OF TRIPEPTIDEMIMETICS WITH ARYLKETONE AS INHIBITORS OF SARS-COV 3CL PROTEASE2011
- Author(s)
  Sho Konno, Yoshio Hayashi, 他11名
- Organizer
  第48回ペプチド討論会
- Place of Presentation
  札幌
- Year and Date
  2011-09-28
- Data Source
  KAKENHI-PROJECT-23390029
[Presentation] Water-soluble Prodrug of Anti-microtubule Agent 'Plinabulin' : Unique Monolactim System with Click Chemistry with Click Chemistry2011
- Author(s)
  Fumika Yakushiji, Yoshio Hayashi, 他4人
- Organizer
  8th AFMC International Medicinal Chemistry Symposium
- Place of Presentation
  東京
- Year and Date
  2011-12-01
- Data Source
  KAKENHI-PROJECT-23390029
[Presentation] 分子平面性を強化したTryprostatin誘導体の合成研究2010
- Author(s)
  篠崎雄希、山本美彦、嶽野遥、山崎有理、薬師寺文華、林良雄
- Organizer
  第54回日本薬学会関東支部大会
- Place of Presentation
  東京
- Year and Date
  2010-10-02
- Data Source
  KAKENHI-PROJECT-20390036
[Presentation] ジケトピペラジン型微小管作用薬Plinabulinを基盤としたケミカルプローブの開発2010
- Author(s)
  山崎有理、角倉真紀子、河野享子、日高興士、安井裕之、木曽良明、薬師寺文華、林良雄
- Organizer
  日本ケミカルバイオロジー学会第5回年会
- Place of Presentation
  東京
- Year and Date
  2010-05-18
- Data Source
  KAKENHI-PROJECT-20390036
[Presentation] "Plinabulin" a diketopiperazine-type vascular targeting anti-cancer agent based on microtubule depolymerization activity2010
- Author(s)
  Hayashi, Y., Yamazaki, Y., Sumikura, M., Yoshida, T., Mori, Y., Yasui, H., Kohno, K., Kiso, Y., Neuteboom, S., Potts, B., Lloyd, G.K.
- Organizer
  ACS Spring 2010 National Meeting & Exposition
- Place of Presentation
  San Francisco, USA
- Year and Date
  2010-03-21
- Data Source
  KAKENHI-PROJECT-20390036
[Presentation] Plinabulinケミカルプローブの開発とプローブの機能評価2010
- Author(s)
  林良雄、山崎有理
- Organizer
  第14回日本がん分子標的治療学会学術集会
- Place of Presentation
  東京
- Year and Date
  2010-07-06
- Data Source
  KAKENHI-PROJECT-20390036
[Presentation] 微小管作用薬Plinabulinの作用様式解明を目指したケミカルプローブの開発2010
- Author(s)
  山崎有理、城戸結衣、日高輿士、安井裕之、木曽良明、薬師寺文華、林良雄
- Organizer
  第29回メディシナルケミストリーシンポジウム
- Place of Presentation
  京都
- Year and Date
  2010-11-17
- Data Source
  KAKENHI-PROJECT-20390036
[Presentation] Efficient total synthesis of dipeptidic antibiotics (+)-negamycin and its derivatives for development of duchenne muscular dystrophy chemotherapy2010
- Author(s)
  Yoshio Hayashi
- Organizer
  13th Akabori Conference Japanese-German Symposium on Peptide Science
- Place of Presentation
  Leipzig, Germany
- Year and Date
  2010-09-11
- Data Source
  KAKENHI-PROJECT-20390036
[Presentation] 微小管重合阻害剤Plinabulinにおける水溶性プロドラッグの創製2010
- Author(s)
  薬師寺文華、岡本玲子、山崎有理、林良雄
- Organizer
  第29回メディシナルケミストリーシンポジウム
- Place of Presentation
  京都
- Year and Date
  2010-11-17
- Data Source
  KAKENHI-PROJECT-20390036
[Presentation] 新生血管を障害するチューブリン重合阻害剤の創製2010
- Author(s)
  林良雄
- Organizer
  日本放射線腫瘍学会第23回学術大会
- Place of Presentation
  千葉
- Year and Date
  2010-11-18
- Data Source
  KAKENHI-PROJECT-20390036
[Presentation] 新生血管内皮細胞を障害するジケトピペラジン型微小管脱重合剤の創製2010
- Author(s)
  林良雄、山崎有理
- Organizer
  第14回日本がん分子標的治療学会学術集会
- Place of Presentation
  東京
- Year and Date
  2010-07-06
- Data Source
  KAKENHI-PROJECT-20390036
[Presentation] Plinabulin a diketopiperazine-type vascular targeting anti-cancer agent based on microtubule depolymerization activity2010
- Author(s)
  Yoshio Hayashi
- Organizer
  ACS Spring 2010 National Meeting & Exposition
- Place of Presentation
  San Francisco, USA
- Year and Date
  2010-03-22
- Data Source
  KAKENHI-PROJECT-20390036
[Presentation] 酸触媒環化反応を用いたモノデヒドロ-2,5-ジケトピペラジン化合物の合成研究2010
- Author(s)
  山崎有理、森雄樹、小田暁子、奥野友香、木曽良明、林良雄
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Year and Date
  2010-03-28
- Data Source
  KAKENHI-PROJECT-20390036
[Presentation] Plinabulin a diketopiperazine .type vascular targeting anti-cancer agent based on microtubule depolymerization activity2010
- Author(s)
  Yoshio Hayashi
- Organizer
  ACS Spring 2010 National Meeting & Exposition
- Place of Presentation
  San Francisco, USA(招待後援)
- Year and Date
  2010-03-22
- Data Source
  KAKENHI-PROJECT-20390036
[Presentation] Synthesis of (+)-Negamycin and Derivatives2009
- Author(s)
  Yakushiji, F., Nishiguchi, S., Sydnes, M.O., Taguchi, A., Regnier, T., Kajimoto, T., Node, M., Kiso, Y., Yamazaki, Y., Hayashi, Y.
- Organizer
  3rd Asia-Pacific International Peptide Symposium / 13th Korean Peptide and Protein Symposium : "Peptides at Cutting Edge"
- Place of Presentation
  Jeju Island, Korea
- Year and Date
  2009-11-08
- Data Source
  KAKENHI-PROJECT-20659017
[Presentation] Synthesis and structure-activity relationship study of cyclic dipeptide-based microtubule depolymerization agents with a benzophenone structure2009
- Author(s)
  Sumikura, M., Yamazaki, Y., Yoshida, T., Mori, Y., Yasui, H., Kiso, Y., Neuteboom, S., Potts, B., Lloyd, G.K., Hayashi, Y.
- Organizer
  46th Japanese Peptide Symposium
- Place of Presentation
  Kitakyushu, Japan
- Year and Date
  2009-11-04
- Data Source
  KAKENHI-PROJECT-20390036
[Presentation] Efficient Total Synthesis of (+)-Negamycin and Its Derivatives as Potential Chem otherapeutic Agents for Genetic Disease2009
- Author(s)
  Taguchi, A., Nishiguchi, S., Regnier, T., Sydnes, M.O., Ozeki, M., Node, M., Kiso, Y., Hayashi, Y.
- Organizer
  7th AFMC International Medicinal Chemistry Congress
- Place of Presentation
  Cairns, Australia
- Year and Date
  2009-08-23
- Data Source
  KAKENHI-PROJECT-20659017
[Presentation] ジケトピペラジン型光応答性プローブの開発とチューブリン認識能評価2009
- Author(s)
  山崎有理, 林良雄, 他9人
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Year and Date
  2009-03-26
- Data Source
  KAKENHI-PROJECT-20390036
[Presentation] Efficient total synthesis of dipeptidic antibiotics (+)-negamycin and its derivatives.2009
- Author(s)
  Hayashi, Y., Taguchi, A., Regnier, T., Nishiguchi, S., Kiso, Y.
- Organizer
  21st American Peptide Symposium
- Place of Presentation
  Bloomington, IN, USA
- Year and Date
  2009-06-07
- Data Source
  KAKENHI-PROJECT-20659017
[Presentation] ベンゾフェノン構造を有するジケトピペラジン型微小管脱重合剤の開発2009
- Author(s)
  角倉真紀子、山崎有理、吉田智子、森雄樹、安井裕之、木曽良明、Saskia Neuteboom, Barbara Potts, G.Kenneth Lloyd, 林良雄
- Organizer
  第28回メディシナルケミストリーシンポジウム
- Place of Presentation
  東京
- Year and Date
  2009-11-25
- Data Source
  KAKENHI-PROJECT-20390036
[Presentation] Synthesis and Antimicrobial Activity of (+)-Negamycin Derivatives Focused on the Hydrazine Amide Moiety2009
- Author(s)
  Taguchi, A., Ina, M., Yamazaki, Y., Yakushiji, F., Takahashi, Y., Kiso, Y., Hayashi, Y.
- Organizer
  46th Japanese Peptide Symposium
- Place of Presentation
  北九州
- Year and Date
  2009-11-04
- Data Source
  KAKENHI-PROJECT-20659017
[Presentation] ペプチドを基盤とする統合創薬研究2009
- Author(s)
  林良雄
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Year and Date
  2009-03-27
- Data Source
  KAKENHI-PROJECT-20390036
[Presentation] Acid catalyzed monodehydro-2,5-diketopiperazine formation toward natural product synthesis2009
- Author(s)
  Yamazaki, Y., Mori, Y., Oda, A., Kiso, Y., Hayashi, Y.
- Organizer
  21st American Peptide Symposium
- Place of Presentation
  Bloomington, IN, USA
- Year and Date
  2009-06-07
- Data Source
  KAKENHI-PROJECT-20390036
[Presentation] Cyclic dipeptide-based microtubule depolymerization agents as vascular targeting anti-cancer drugs2009
- Author(s)
  Y.Hayashi
- Organizer
  7th AFMC International Medicinal Chemistry Congress
- Place of Presentation
  Cairns, Australia(口頭発表)
- Year and Date
  2009-08-27
- Data Source
  KAKENHI-PROJECT-20390036
[Presentation] Cyclic dipeptide-based microtu-bule depolymerization agents as vascular targeting anti-cancer drugs2009
- Author(s)
  Y. Hayashi
- Organizer
  7th AFMC Inter-national Medicinal Chemistry Congress
- Place of Presentation
  Cairns, Australia
- Year and Date
  2009-08-27
- Data Source
  KAKENHI-PROJECT-20390036
[Presentation] Plinabulin a cyclic dipeptide-based vascular targeting anti-cancer agent based on microtubule depolymerization activity2009
- Author(s)
  Yoshio Hayashi
- Organizer
  3rd Asia-Pacific International Peptide Symposium/13th Korean Peptide and Protein Symposium : "Peptides at Cutting Edge"
- Place of Presentation
  Jeju Island, Korea(口頭発表)
- Year and Date
  2009-11-09
- Data Source
  KAKENHI-PROJECT-20390036
[Presentation] (+)-ネガマイシンの効率的な全合成研究2009
- Author(s)
  田口晃弘, 林良雄, 他6名
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Year and Date
  2009-03-27
- Data Source
  KAKENHI-PROJECT-20659017
[Presentation] Plinabulin a cyclic dipeptide-based vascular targeting anti-cancer agent based on microtubule depolymerization activity2009
- Author(s)
  Yoshio Hayashi
- Organizer
  3rd Asia-Pacific International Peptide Symposium/13th Korean Peptide and Protein Symposium :"Peptides at Cutting Edge"
- Place of Presentation
  Jeju Island, Korea
- Year and Date
  2009-11-09
- Data Source
  KAKENHI-PROJECT-20390036
[Presentation] "Plinabulin" a cyclic dipeptide-based vascular targeting anti-cancer agent based on microtubule depolymerization activity2009
- Author(s)
  Hayashi, Y., Yamazaki, Y., Sumikura, M., Yoshida, T., Mori, Y., Yasui, H., Kohno, K., Kiso, Y., Neuteboom, S., Potts, B., Lloyd, G.K.
- Organizer
  3rd Asia-Pacific International Peptide Symposium / 13th Korean Peptide and Protein Symposium
- Place of Presentation
  Jeju Island, Korea
- Year and Date
  2009-11-08
- Data Source
  KAKENHI-PROJECT-20390036
[Presentation] Cyclic dipeptide-based microtubule depolymerization agents as vascular targeting anti-cancer drugs2009
- Author(s)
  Yamazaki, Y., Sumikura, M., Yoshida, T., Mori, Y., Yasui, H., Kohno, K., Kiso, Y., Deyanat-Yazdi, G., Neuteboom, S., Potts, B., Lloyd, G.K., Hayashi, Y.
- Organizer
  7th AFMC International Medicinal Chemistry Congress
- Place of Presentation
  Cairns, Australia
- Year and Date
  2009-08-23
- Data Source
  KAKENHI-PROJECT-20390036
[Presentation] 小分子ペプチドを基盤とする創薬科学研究2008
- Author(s)
  林良雄
- Organizer
  第10回創薬ビジョンシンポジウム
- Place of Presentation
  東京
- Year and Date
  2008-11-27
- Data Source
  KAKENHI-PROJECT-20390036
[Presentation] (+)-ネガマイシンおよびその誘導体の効率的合成2008
- Author(s)
  田口晃弘, 林良雄, 他5人
- Organizer
  第45回ペプチド討論会
- Place of Presentation
  東京
- Year and Date
  2008-10-30
- Data Source
  KAKENHI-PROJECT-20659017
[Presentation] 新規水溶性光保護基の開発とPaclitaxelへの応用2008
- Author(s)
  野口真代, 林良雄, 他5名
- Organizer
  第34回反応と合成の進歩シンポジウム
- Place of Presentation
  京都
- Year and Date
  2008-11-04
- Data Source
  KAKENHI-PROJECT-20390036
[Presentation] Synthesis of biotin-tagged photoaffinity probes for diketopiperazine-basedanti-microtubule agents.2008
- Author(s)
  Yuri Yamazaki, Yoshio Hayashi, 他9名
- Organizer
  International Symposium on Integrated Medicinal Science
- Place of Presentation
  Kyoto
- Year and Date
  2008-12-13
- Data Source
  KAKENHI-PROJECT-20390036
[Presentation] 小分子ペプチドを基盤とする創薬科学研究2008
- Author(s)
  林良雄
- Organizer
  第10回創薬ビジョンシンポジウム
- Place of Presentation
  東京
- Year and Date
  2008-11-27
- Data Source
  KAKENHI-PROJECT-20659017
[Presentation] ネガマイシンの全合成研究-Duchenne型筋ジストロフィー治療薬開発をめざして-2008
- Author(s)
  林良雄, 田口晃弘, 他9名
- Organizer
  第34回反応と合成の進歩シンポジウム
- Place of Presentation
  京都
- Year and Date
  2008-11-05
- Data Source
  KAKENHI-PROJECT-20659017
[Presentation] A new microtubule targeting agent as a vascular targeting anti-cancer drug2008
- Author(s)
  Yoshio Hayashi
- Organizer
  12th Akabori Conference : German-Japanese Symposium on Peptide Science
- Place of Presentation
  Kyoto
- Year and Date
  2008-05-16
- Data Source
  KAKENHI-PROJECT-20390036
[Presentation] 酸触媒を用いるモノデヒドロ-2, 5-ジケトピペラジン類の合成研究2008
- Author(s)
  山崎有理, 林良雄, 他5名
- Organizer
  第34回反応と合成の進歩シンポジウム
- Place of Presentation
  京都
- Year and Date
  2008-11-05
- Data Source
  KAKENHI-PROJECT-20390036
[Presentation] 小分子ペプチドを基盤とした難病治療薬の創製研究2008
- Author(s)
  林良雄, 他6人
- Organizer
  第45回ペプチド討論会
- Place of Presentation
  東京
- Year and Date
  2008-10-31
- Data Source
  KAKENHI-PROJECT-20390036
[Presentation] 小分子ペプチドを基盤とする難病克服をめざした創薬研究2008
- Author(s)
  林良雄
- Organizer
  日本化学会第2回関東支部大会
- Place of Presentation
  群馬
- Year and Date
  2008-09-19
- Data Source
  KAKENHI-PROJECT-20390036
[Presentation] A new microtubule targeting agent as a vascular targeting anti-cancer drug2008
- Author(s)
  Yoshio Hayashi
- Organizer
  12th Akabori Conference : German-Japanese Symposium on Peptide Science
- Place of Presentation
  Kyoto(口頭発表)
- Year and Date
  2008-05-16
- Data Source
  KAKENHI-PROJECT-20390036
[Presentation] Development of biotin-tagged cyclicdipeptied based anti-microtubuleagents and tubulin photoaffinity labeling2008
- Author(s)
  Yuri Yamazaki, Yoshio Hayashi, 他6人
- Organizer
  32nd European Peptide Symposium (30EPS)
- Place of Presentation
  Helsinki, Finland
- Year and Date
  2008-08-31
- Data Source
  KAKENHI-PROJECT-20390036
[Presentation] 天然物合成を目指したモノデヒドロ環状ジペプチドの合成研究2008
- Author(s)
  森雄樹, 林良雄, 他5人
- Organizer
  第45回ペプチド討論会
- Place of Presentation
  東京
- Year and Date
  2008-10-29
- Data Source
  KAKENHI-PROJECT-20390036
[Presentation] ジケトピペラジン型微小管作用薬を基盤としたビオチン導入型光応答性分子プローブの開発2008
- Author(s)
  山崎有理, 林良雄, 他6人
- Organizer
  第45回ペプチド討論会
- Place of Presentation
  東京
- Year and Date
  2008-10-29
- Data Source
  KAKENHI-PROJECT-20390036
[Presentation] ジケトピペラジン型Vascular Disrupting Agent NPI-2358 誘導体の合成と構造活性相関2008
- Author(s)
  森雄樹, 林良雄, 他8人
- Organizer
  第27回メディシナルケミストリーシンポジウム
- Place of Presentation
  京都
- Year and Date
  2008-11-27
- Data Source
  KAKENHI-PROJECT-20390036
[Presentation] 分子内転位反応を用いたプロドラッグの合成戦略と新規抗がん剤の創製2008
- Author(s)
  林良雄
- Organizer
  第24回日本DDS学会
- Place of Presentation
  東京
- Year and Date
  2008-06-29
- Data Source
  KAKENHI-PROJECT-20390036
[Presentation] Efficient total synthesis of(+)-negamycin, a potential chemotherapeutic agent for genetic diseases.2008
- Author(s)
  Yoshio Hayashi, Thomas. Regnier, Shigenobu Nishiguchi, 他9人
- Organizer
  IUPAC/ICOS-17 : 17th International Conference on Organic Synthesi
- Place of Presentation
  Daejeon, Korea
- Year and Date
  2008-06-22
- Data Source
  KAKENHI-PROJECT-20659017
[Presentation] Synthesis of(+)-Negamycin as a potential drug lead against duchennemuscular dystrophy2008
- Author(s)
  Yoshio Hayashi, Thomas Regnier, 他6名
- Organizer
  International Symposium on Integrated Medicinal Science
- Place of Presentation
  京都
- Year and Date
  2008-12-13
- Data Source
  KAKENHI-PROJECT-20659017
[Presentation] 可視光線により腫瘍部位特異的にパクリタキセルを再生するプロドラッグの開発2007
- Author(s)
  野口真代, 林良雄
- Organizer
  第11回がん分子標的治療研究会総会POP研究
- Place of Presentation
  大阪
- Year and Date
  2007-07-05
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590099
[Presentation] Development of new photoresponsive paclitaxel prodrug2007
- Author(s)
  Noguchi, M., Hayashi, Y., 他5名
- Organizer
  44th Japanese Peptide Symposium
- Place of Presentation
  Toyama
- Year and Date
  2007-11-08
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590099
[Presentation] Synthesis of Polylactides with Side Chain Functionality : Ring-Opening Polymerization of a Homobislactone Prepared from Lysine2007
- Author(s)
  Kodera, H., Kiso, Y., Hayashi, Y., Nishishita, N., Hirano, Y
- Organizer
  20th American Peptide Symposium Peptides for Youth
- Place of Presentation
  Montreal, Canada
- Year and Date
  2007-07-26
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590099
[Presentation] 腫瘍部位特異的に再生可能なpaclitaxelの光応答性プロドラッグphototaxelの開発2007
- Author(s)
  野口真代, 林良雄, 他5名
- Organizer
  難病克服をめざした創薬科学合同研究成果発表会
- Place of Presentation
  京都
- Year and Date
  2007-01-26
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590099
[Presentation] Synthesis of Polylactides with Side Chain Functionality:Ring-Opening Polymerization of a Homobislactone Prepared from Lysine2007
- Author(s)
  Kodera, H., Hayashi, Y., 他3名
- Organizer
  20th American Peptide Symposium
- Place of Presentation
  Monreal,Canada
- Year and Date
  2007-06-26
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590099
[Presentation] 微小管作用に基づくジケトピペラジン型Vascular Disrupting Agentの創製2007
- Author(s)
  林良雄、山崎有理
- Organizer
  第11回がん分子標的治療研究会総会
- Place of Presentation
  大阪
- Year and Date
  2007-07-06
- Data Source
  KAKENHI-PROJECT-18032081
[Presentation] A new aspect of microtubule targeting agents as anti-cancer drugs.2007
- Author(s)
  Y. Hayashi, Y. Yamazaki 他3名
- Organizer
  The 6th International Symposium on Frontiers in Protein Chemistry and Biotechnology
- Place of Presentation
  Changchun, China
- Year and Date
  2007-08-21
- Data Source
  KAKENHI-PROJECT-18032081
[Presentation] 0-N Intramolecular Acyl and Alkoxycarbonyl Migration Reactions:From the Prodrug Strategv to the Migration of Protective Groups in Amino Acids2007
- Author(s)
  Skwarczynski, M., Hayashi, Y., 他4名
- Organizer
  First Indian Peptide Symposium
- Place of Presentation
  Hyderabad,India
- Year and Date
  2007-02-22
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590099
[Presentation] Application of Intramolecular Migration Reaction in Peptide Chemistry to Chemical Biology, Chemical Pharmaceutics and Medicinal Chemistry2007
- Author(s)
  Y. Hayashi, Y. Yamazaki, M. S kwarczynski, 他7名
- Organizer
  20th American Peptide Symposium
- Place of Presentation
  Montreal, Canada
- Year and Date
  2007-07-26
- Data Source
  KAKENHI-PROJECT-17590099
[Presentation] 側鎖にアミノ基を有するhomobislactoneを原料とするカチオン型乳酸ポリマーの合成2007
- Author(s)
  林良雄, 小寺宏実, 他3名
- Organizer
  日本薬学会第127年会
- Place of Presentation
  富山
- Year and Date
  2007-03-28
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590099
[Presentation] 微小管を標的とする新規Vascular Disrupting Agentの作用機序研究-光標識プローブの開発とその利用-2007
- Author(s)
  林良雄、山崎有理、他7名
- Organizer
  日本ケミカルバイオロジー研究会第2回年会
- Place of Presentation
  京都
- Year and Date
  2007-05-09
- Data Source
  KAKENHI-PROJECT-18032081
[Presentation] Application of O-N intramolecular alkoxycarbonyl migration reaction:from prodrug strategy to migration of protective groups2007
- Author(s)
  Skwarczynski, M., Hayashi, Y., 他4名
- Organizer
  難病克服をめざした創薬科学合同研究成果発表会
- Place of Presentation
  京都
- Year and Date
  2007-01-26
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590099
[Presentation] Photo-triggered targeting prodrug of paclitaxel2007
- Author(s)
  Skwarczynski, M., Hayashi, Y., 他5名
- Organizer
  2nd European Conference on Chemistry for Life Sciences
- Place of Presentation
  Wroclaw,Poland
- Year and Date
  2007-09-06
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590099
[Presentation] Application of Intramolecular Migration Reaction in Peptide Chemistry to Chemical Biology, Chemical Pharmaceutics and Medicinal Chemistry.2007
- Author(s)
  Y. Hayashi, Y. Yamazaki 他8名
- Organizer
  20th American Peptide Symposium
- Place of Presentation
  Montreal, Canada
- Year and Date
  2007-06-27
- Data Source
  KAKENHI-PROJECT-18032081
[Presentation] 腫瘍部位特異的に再生可能なpaclitaxelの光応答性プロドラッグphototaxelの開発2007
- Author(s)
  野口真代, 林良雄, 他5名
- Organizer
  第26回メディシナルケミストリーシンポジウム
- Place of Presentation
  相模大野
- Year and Date
  2007-11-29
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590099
[Presentation] Synthesis of Polylactides with Side Chain Functionality: Ring-Opening Polymerization of a Homobislactone Prepared from Lysine2007
- Author(s)
  Kodera, H., Kiso, Y., Hayashi, Y., 他2名
- Organizer
  20th American Peptide Symposium
- Place of Presentation
  Montreal, Canada
- Year and Date
  2007-07-26
- Data Source
  KAKENHI-PROJECT-17590099
[Presentation] Synthesis of Polylactides with Side Chain Functionality: Ring-〇pening Polymerization of a Homobislactone Prepared from Lysine2007
- Author(s)
  H. Kodera, Y. Kiso, Y. Hayashi 他2名
- Organizer
  20th American Peptide Symposium
- Place of Presentation
  Montreal, Canada
- Year and Date
  2007-06-29
- Data Source
  KAKENHI-PROJECT-18032081
[Presentation] New approaches of microtubule targeting agents as anti-cancer drugs.2007
- Author(s)
  Y. Hayashi, Y. Yamazaki 他3名
- Organizer
  The 4th Takeda Science Foundation Symposium on Pharma Sciences
- Place of Presentation
  東京
- Year and Date
  2007-12-03
- Data Source
  KAKENHI-PROJECT-18032081
[Presentation] Photo-triggered targeting prodrug of paclitaxel2007
- Author(s)
  Skwarczynski, M., Noguchi, M., Hirota, S., Sohma, Y., Kimura, T., Hayashi, Y., Kiso, Y
- Organizer
  2nd European Conference on Chemistry for Life Sciences
- Place of Presentation
  Wroclaw, Poland
- Year and Date
  2007-09-06
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590099
[Presentation] O-N Intramolecular Acyl and Alkoxycarbonyl Migration Reactions From the Prodrug Strategy to the Migration of Protective Groups in Amino Acids2007
- Author(s)
  Skwarczynski, M., Noguchi, M., Sohma, Y., Kimura, T., Hayashi, Y., Kiso, Y
- Organizer
  First Indian Peptide Symposium
- Place of Presentation
  Hyderabad, India
- Year and Date
  2007-02-22
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590099
[Presentation] 腫瘍特異性を指向したpaclitaxelの光応答性プロドラッグphototaxelの開発2006
- Author(s)
  Skwarczynski, M., Hayashi, Y., 他5名
- Organizer
  第25回メディシナルケミストリーシンポジウム
- Place of Presentation
  名古屋
- Year and Date
  2006-11-28
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590099
[Presentation] Intramolecular Nucleophilic Reactions in Peptide Chemistry;Application to Peptide Synthesis and Medicinal Chemistry2006
- Author(s)
  Hayashi, Y., Sohma, Y., 他3名
- Organizer
  The 11th Akabori Conference(Japanses-German Symposium on Peptide Science)
- Place of Presentation
  Kloster Banz,Germany
- Year and Date
  2006-09-12
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590099
[Presentation] Toward Smarter Delivery of Paclitaxel : Application of O-N Intramolecular Acyl and Alkoxycarbonyl Migrations2006
- Author(s)
  Skwarczynski, M., Noguchi, M., Sohma, Y., Hirota, S., Kimura, T., Hayashi, Y., Kiso, Y
- Organizer
  2nd International Symposium on Biomolecules and Related Compounds
- Place of Presentation
  Kyoto
- Year and Date
  2006-11-10
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590099
[Presentation] Phototaxel:Development of first Photoresponsive Prodrug of Paclitaxel via Modification of Phenylisoserine Moiety2006
- Author(s)
  Skwarczynski, M., Hayashi, Y., 他5名
- Organizer
  International Conference of 43rd Japanese Peptide Symposium and (四)th Peptide Engineering Meeting
- Place of Presentation
  Yokohama
- Year and Date
  2006-11-06
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590099
[Presentation] Oligoarginine prodrugs bearing self-cleavable peptide spacers for effective intestinal absorption2006
- Author(s)
  Hayashi, Y., Takayama, 他5名
- Organizer
  2nd International Symposium on Biomolecules and Related Compounds
- Place of Presentation
  Kyoto
- Year and Date
  2006-11-10
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590099
[Presentation] Development of resin supported Evans-type chiral auxiliary for solid-phase asymmetric reaction2006
- Author(s)
  Hayashi, Y., Kotake, T., Nishiguchi, S., Rajesh, S., Kimura, T., Kiso, Y
- Organizer
  ICOB-5 & ISCNP-25 IUPAC International Conference on Biodiversity and Natural Products
- Place of Presentation
  Kyoto, Japan
- Year and Date
  2006-07-26
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590099
[Presentation] New approaches of microtubule targeting agents as anti-cancer drugs.International Symposium on Chemistry2006
- Author(s)
  Hayashi, Y., Skwarczynski, M., 他2名
- Organizer
  International Symposium on Chemistry, Biology & Medicine
- Place of Presentation
  Cyprus
- Year and Date
  2006-05-30
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590099
[Presentation] Development of first photoactivated prodrug of paclitaxel via modification of phenylisoserine moiety2006
- Author(s)
  Hayashi, Y., Skwarczynski, M., 他5名
- Organizer
  29th European Peptide Symposium
- Place of Presentation
  Gdansk,Poland
- Year and Date
  2006-09-04
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590099
[Presentation] O-N intramolecular acyl and alkoxycarbonyl migrations:toward smarter delivery of paclitaxel2006
- Author(s)
  Skwarczynski, M., Hayashi, Y., 他5名
- Organizer
  Integrated Center of Excellence for Medicinal Chemistry of Neuropeptides"From Endogenous systems to Medicines
- Place of Presentation
  Warsaw,Poland
- Year and Date
  2006-09-09
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590099
[Presentation] Toward Smarter Delivery of Paclitaxel:Application of O-N Intrmolecular Acyl and Alkoxycarbonyl Migrations2006
- Author(s)
  Skwarczynski, M., Hayashi, Y., 他5名
- Organizer
  2nd International symposium on Biomolecules and Related Compounds
- Place of Presentation
  Kyoto
- Year and Date
  2006-11-11
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590099
[Presentation] Chemical Phamlaceuticsを志向した創薬化学2006
- Author(s)
  林良雄
- Organizer
  日本薬学会第126年会シンポジウム
- Place of Presentation
  仙台
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590099
[Presentation] Synthesis of tnfluoromethyl ketone-containing glutamic acid and glutamine peptides as severe acute respiratory syndrome coronavirus 3CL protease inhibitors2006
- Author(s)
  Sydnes, M.O., Hayashi, Y., Sharma, V.K., Hamada, T., Bacha, U., Barrila, J., Freire, E., Kiso, Y
- Organizer
  29th European Peptide Symposium
- Place of Presentation
  Gdansk, Poland
- Year and Date
  2006-09-05
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590099
[Presentation] フェニルイソセリン基の修飾によるpaclitaxelの光応答性プロドラッグの開発2006
- Author(s)
  Skwarczynski, M., Hayashi, Y., 他5名
- Organizer
  第32回反応と合成の進歩シンポジウム
- Place of Presentation
  広島
- Year and Date
  2006-12-04
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590099
[Presentation] O-N Intramolecular carbonate-carbamate migration:Application to no byproduct strategy in water-soluble prodrugs of taxoids and migration of protective groups in amino acids2006
- Author(s)
  M.Skwarczynski, Y.Hayashi, 他4名
- Organizer
  Joint International Symposium on Integrated Medicinal Science for Drug Discovery
- Place of Presentation
  Kyoto
- Year and Date
  2006-03-06
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590099
[Presentation] Development of resin supported Evans-type chiral auxiliary for solid-phase asymmetric reaction2006
- Author(s)
  Y.Hayashi, T.Kotake, 他4名
- Organizer
  ICOB-5&ISCNP-25 IUPAC International Conference on Biodiversity and Natural Products
- Place of Presentation
  Kyoto,Japan
- Year and Date
  2006-07-26
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590099
[Presentation] O-N Intramolecular carbonate-carbamate migration : from water-soluble taxoid prodrugs to migration of protective groups2006
- Author(s)
  Skwarczynski, M., Sohma, Y., Noguchi, M., Hayashi, Y., Kimura, T., Kiso Y
- Organizer
  7th Tetrahedron Symposium : Challenges in Organic Chemistry
- Place of Presentation
  Kyoto, Japan
- Year and Date
  2006-05-25
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590099
[Presentation] アルツハイマー病・がんを標的としたペプチド基盤生物有機化学研究2006
- Author(s)
  林良雄
- Organizer
  大阪大学蛋白質研究所セミナー
- Place of Presentation
  吹田
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590099
[Presentation] O-N Intramolecular carbonate-carbamate migration: from water-soluble taxoid prodrugs to migration of migration of protective groups2006
- Author(s)
  M.Skwarczynski, Y.Hayashi, 他4名
- Organizer
  7th Tetrahedron Symposium:
- Place of Presentation
  Kyoto,Japan
- Year and Date
  2006-05-25
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590099
[Presentation] Synthesis of trifluoromethyl ketone-containing glutamic acid and glutamine peptides as severe acute respiratory syndrome coronavirus 3CL protease inhibitors2006
- Author(s)
  Sydnes, M.S., Hayashi, Y., 他4人
- Organizer
  29th European Peptide Symposium
- Place of Presentation
  Gdansk,Poland
- Year and Date
  2006-09-05
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590099
[Presentation] New approaches of microtubule targeting agents as anti-cancer drugs.2006
- Author(s)
  Hayashi, Y., Skwarczynski, M., Kiso, Y., Lloyd, G.K
- Organizer
  International Symposium on Chemistry, Biology & Medicine
- Place of Presentation
  Cyprus
- Year and Date
  2006-05-30
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590099
[Presentation] Phototaxel : Development of first Photoresponsive Prodrug of Paclitaxel via Modification of Phenylisoserine Moiety2006
- Author(s)
  Skwarczynski, M., Noguchi, M., Hirota, S., Sohma, Y., Kimura, T., Hayashi, Y., Kiso, Y
- Organizer
  International Conference of 43rd Japanese Peptide Symposium and 4th Peptide Engineering Meeting
- Place of Presentation
  Yokohama
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590099
[Presentation] Development of phototaxel : first photosensitive prodrug of paclitaxel2006
- Author(s)
  Skwarczynski, M., Noguchi, M., Hirota, S., Sohma, Y., Kimura, T., Hayashi, Y., Kiso, Y
- Organizer
  2nd International Symposium on Biomolecules and Related Compounds
- Place of Presentation
  Kyoto
- Year and Date
  2006-11-11
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590099
[Presentation] O-N intramolecular acyl and alkoxycarbonyl migrations toward smarter delivery of paclitaxel2006
- Author(s)
  Slcwarczynski, M., Noguchi, M., Sohma, Y., Hirota, S., Kimura, T., Hayashi, Y., Kiso Y
- Organizer
  Integrated Center Of Excellence For Medicinal Chemistry Of Neuropeptides "From Endogenous Systems to Medicines
- Place of Presentation
  Warsaw, Poland
- Year and Date
  2006-09-09
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590099
[Presentation] Development of first photoactivated prodrug of paclitaxel via modification of phenylisoserine moiety2006
- Author(s)
  Skwarczynslu, M., Noguchi, M., Hirota, S., Sohma, Y., Kimura, T., Hayashi, Y., Kiso, Y
- Organizer
  29th European Peptide Symposium
- Place of Presentation
  Gdansk, Poland
- Year and Date
  2006-09-04
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590099
[Presentation] Lysから誘導したhomobislactonc体響とするカチオン型乳酸ポリマーの合成2006
- Author(s)
  林良雄, 小寺宏実, 他2名
- Organizer
  第56回日本薬学会近畿支部総会・大会
- Place of Presentation
  京都
- Year and Date
  2006-10-20
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590099
[Presentation] Synthesis of peptides possessing a trifluoromethyl ketone moiety as inhibitors for severeacute respiratory syndrome coronavirus2006
- Author(s)
  Sydnes, M.S, , Hayashi, Y., 他4人
- Organizer
  7th Tetrahedron Symposium:
- Place of Presentation
  Kyoto,Japan
- Year and Date
  2006-05-25
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590099
[Presentation] O-N Intramolecular carbonate-carbamate migration : Application to no byproduct strategy in water-soluble prodrugs of taxoids and migration of protective groups in amino acids2006
- Author(s)
  Skwarczynslu, M., Sohma, Y., Noguchi, M., Kimura, M., Hayashi, Y., Kiso, Y
- Organizer
  Joint International Symposium on Integrated Medicinal Science for Drug Discovery-Tradition to Structural Biology/Medicinal Science Research on Difficult Diseases
- Place of Presentation
  Kyoto
- Year and Date
  2006-03-06
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590099
[Presentation] Synthesis of peptides possessing a trifluoromethyl ketone moiety as inhibitors for severe acute respiratory syndrome coronavirus2006
- Author(s)
  Sydnes, M, O, Hayashi, Y, Sharma, V, K, Barrila, J, Freire, E, Kiso, Y
- Organizer
  7th, Tetrahedron Symposium : Challenges in Organic Chemistry
- Place of Presentation
  Kyoto, Japan
- Year and Date
  2006-05-25
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590099
[Presentation] Intramolecular Nucleophilic Reactions in Peptide Chemistry ; Application to Peptide Synthesis and Medicinal Chemistry2006
- Author(s)
  Hayashi, Y., Sohma, Y., Taniguchi, A., Skwarczynski, M., Kiso, Y
- Organizer
  The 11th Akabon Conference (Japanese-German Symposium on Peptide Science)
- Place of Presentation
  Kloster Banz, Germany
- Year and Date
  2006-09-12
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590099
[Presentation] Development of Wang resin supported Evans-type oxazolidinone for asymmetric reaction2005
- Author(s)
  Y.Hayashi, T.Kotake, 他3名
- Organizer
  International Symposium:New Developments in Synthetic Organic Chemistry of Natural Products and Medicines
- Place of Presentation
  Kyoto,Japan
- Year and Date
  2005-09-17
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590099
[Presentation] No by-product strategy in water-soluble taxoid prodrugs : O-N intramolecular acyloxy migration reaction2005
- Author(s)
  Skwarczynslu, M., Sohma, Y., Noguchi, Y., Kimura, M., Hayashi, Y., Hamada, Y., Kimura, T., Kiso, T
- Organizer
  International Symposium : New Developments in Synthetic Organic Chemistry of Natural Products and Medicines
- Place of Presentation
  Kyoto, Japan
- Year and Date
  2005-09-17
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590099
[Presentation] O-N intramolecular acyloxy migration reaction:from the prodrug strategy to the migration of protective groups in amino acids2005
- Author(s)
  M.Skwarczynski, Y.Hayashi, 他6名
- Organizer
  42nd Japanese Peptide Symposium
- Place of Presentation
  Toyonaka,Japan
- Year and Date
  2005-10-28
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590099
[Presentation] No by-product strategy:Application of O-N intramolecular acyl and acyloxy migration to water-soluble taxoid prodrugs2005
- Author(s)
  M.Skwarczynski, Y.Hayashi, 他6名
- Organizer
  2005 international Chemical Congress of Pacific Basin Societies(Pacifichem 2005)
- Place of Presentation
  Honolulu,USA
- Year and Date
  2005-12-17
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590099
[Presentation] Development of Wang resin supported Evans-type oxazolidinone for asymmetric reaction2005
- Author(s)
  Hayashi, Y., Kotake, T., Rajesh, S., Kimura, T., Kiso, Y
- Organizer
  International Symposium : New Developments in Synthetic Organic Chemistry of Natural Products and Medicines
- Place of Presentation
  Kyoto, Japan
- Year and Date
  2005-09-17
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590099
[Presentation] Development of Wang resin supported Evans-type oxazolidinone for asymmetric reaction2005
- Author(s)
  Kotake, T., Hayashi, Y., Rajesh, S., Kimura, T., Kiso, Y
- Organizer
  19th American Peptide Symposium : Understanding Biology Using Peptides
- Place of Presentation
  San Diego, U.S.A
- Year and Date
  2005-06-20
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590099
[Presentation] No by-product strategy in water-soluble taxoid prodrugs:0-N intramolecular acyloxymigration reaction.Intemational Symposium:New Developments in Synthetic Organic ChemistIy ofNatural Products and Medicines2005
- Author(s)
  M.Skwarczynski, Y.Hayashi, 他6名
- Organizer
  Intemational Symposium:New Developments in Synthetic Organic Chemistry of Natural Products and Medicines
- Place of Presentation
  Kyoto,Japan
- Year and Date
  2005-09-17
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590099
[Presentation] α-ヒドロキシ-β-アミノ酸を利用した固相Evans不斉補助基の開発2005
- Author(s)
  林良雄, 小竹智也, 他4名
- Organizer
  第31回反応と合成の進歩シンポジウム
- Place of Presentation
  神戸
- Year and Date
  2005-11-07
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590099
[Presentation] No by-product strategy : Application of O-N intramolecular acyl and acyloxy migration to water-soluble taxoid prodnigs2005
- Author(s)
  Skwarczynski, M., Sohma, Y., Noguchi, M., Kimura, M., Hayashi, Y., Hamada, Y., Kimura, T., Kiso, Y
- Organizer
  international Chemical Congress of Pacific Basin Societies (Pacifichem 2005)
- Place of Presentation
  Honolulu, U.S.A.
- Year and Date
  2005-12-17
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590099
[Presentation] O-N intramolecular acyloxy migration reaction from the prodrug strategy to the migration of protective groups in amino acids2005
- Author(s)
  Skwarczynski, M., Sohma, Y., Noguchi, M., Kimura, M., Hayashi, Y., Hamada, Y., Kimura, T., Kiso, Y
- Organizer
  42nd Japanese Peptide Symposium
- Place of Presentation
  Toyonaka, Japan
- Year and Date
  2005-10-28
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590099
[Presentation] Development of Wang resin supported Evans-type oxazolidinone for asymmetric reactlon2005
- Author(s)
  T.Kotake, Y.Hayashi, 他3名
- Organizer
  19th American Peptide Symposium
- Place of Presentation
  San Diego,U.S.A.
- Year and Date
  2005-06-20
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590099
[Presentation] 0-N分子内アシロキシ転位反応に基づいた新規水溶性taxoidプロドラッグ:isotaxoidsのデザインと合成2005
- Author(s)
  Skwarczynski, M., 林良雄, 他6名
- Organizer
  第31回反応と合成の進歩シンポジウム
- Place of Presentation
  神戸
- Year and Date
  2005-11-08
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590099
[Presentation] Development of New Diketopiperazine-Type Anti-Microtubule Agents with a 2-Pyridylmethylidene Structure
- Author(s)
  Yoshiki Hayashi
- Organizer
  2nd Annual Conference - ICBS 2013
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-23390029
[Presentation] Peptide Therapeutics for the Treatment of Muscular Diseases
- Author(s)
  Yoshio Hayashi
- Organizer
  9th AFMC International Medicinal Chemistry Symposium
- Place of Presentation
  Taipei, Taiwan
- Data Source
  KAKENHI-PROJECT-23390029
[Presentation] リードスルー作用を有するネガマイシン誘導体のC末端部位における構造活性相関研究
- Author(s)
  田口晃弘、濵田圭佑、小竹優也、塩塚政孝、会田　俊、生澤俊太郎、村上沙織、鈴木奈々、高山健太郎、薬師寺文華、野々村禎昭、臼井健郎、松田良一、林　良雄
- Organizer
  第32回メディシナルケミストリーシンポジウム
- Place of Presentation
  神戸
- Year and Date
  2014-11-26 – 2014-11-28
- Data Source
  KAKENHI-PUBLICLY-26102740
[Presentation] Structure Activity Relationship Study of (+)-Negamycin for Readthrough Activity at Duchenne Muscular Dystrophy
- Author(s)
  Akihiro Taguchi, Keisuke Hamada, Masaya Kotake, Masataka Shiozuka, Kentaro Takayama, Fumika Yakushiji, Takeo Usui, Ryoichi Matsuda, Yoshio Hayashi
- Organizer
  33rd European Peptide Symposium
- Place of Presentation
  Sofia, Bulgaria
- Year and Date
  2014-08-31 – 2014-09-05
- Data Source
  KAKENHI-PUBLICLY-26102740
[Presentation] ジペプチド型 SARS-CoV 3CL プロテアーゼ阻害剤の創製研究
- Author(s)
  林　良雄
- Organizer
  第31回メディシナルケミストリーシンポジウム
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-23390029
[Presentation] Development of a series of diketopiperazine vascular targeting anticancer agents based on microtubule depolymerization activity
- Author(s)
  Yoshio Hayashi
- Organizer
  32th European Peptide Symposium
- Place of Presentation
  Athens, Greece
- Invited
- Data Source
  KAKENHI-PROJECT-23390029
[Presentation] Medicinal Chemistry of Small Peptidic Natural Products against Genetic Diseases
- Author(s)
  Yoshio Hayashi
- Organizer
  14th Akabori Conference
- Place of Presentation
  Niseko
- Invited
- Data Source
  KAKENHI-PROJECT-23390029
[Presentation] Medicinal Chemistry of Peptidic Compounds for the Treatment of Muscular Diseases
- Author(s)
  Yoshio Hayashi
- Organizer
  10th Australian Peptide Conference
- Place of Presentation
  Penang, Malaysia
- Invited
- Data Source
  KAKENHI-PROJECT-23390029
[Presentation] Medicinal Chemistry of Small Peptidic Natural Products against Intractable Diseases
- Author(s)
  YoshioHayashi
- Organizer
  International Conference on "Chemistry-Frontiers & Challenges"
- Place of Presentation
  Tamil Nadu,India
- Invited
- Data Source
  KAKENHI-PROJECT-23390029
[Presentation] Structure activity relationship study of (+)- negamycin derivatives at the C-terminal part as a readthrough drug
- Author(s)
  Keisuke Hamada, Akihiro Taguchi, Masaya Kotake, Suguru Aita, Shuntaro Ikezawa, Masataka Shiozuka, Yoshiaki Nonomura, Kentaro Takayama, Fumika Yakushiji, Takeo Usui, Ryoichi Matsuda, Yoshio Hayashi
- Organizer
  18th Korean Peptide Protein Symposium
- Place of Presentation
  Busan, South Korea
- Year and Date
  2014-07-07 – 2014-07-08
- Data Source
  KAKENHI-PUBLICLY-26102740
[Presentation] ピリジン環とベンゾフェノン構造を有する新規ジケトピペラジン型微小管重合阻害剤の創製
- Author(s)
  林　良樹
- Organizer
  第31回メディシナルケミストリーシンポジウム
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-23390029
[Presentation] Medicinal Chemistry of Small Peptidic Natural Products against Genetic Diseases
- Author(s)
  Yoshio Hayashi
- Organizer
  The 1st International Symposium on Chemical Biology of Natural Products: Target ID and Regulation of Bioactivity
- Place of Presentation
  Kyoto
- Invited
- Data Source
  KAKENHI-PROJECT-23390029
[Presentation] 天然由来ペプチド様小分子に基づく難病治療薬の創製研究
- Author(s)
  林　良雄
- Organizer
  BIO tech 2012 アカデミックフォーラム
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23390029
[Presentation] ネガマイシン誘導体におけるC末端部修飾とリードスルー活性への効果
- Author(s)
  濵田圭佑、田口晃弘、小竹優也、生澤俊太郎、会田　俊、塩塚政孝、野々村禎昭、高山健太郎、薬師寺文華、臼井健郎、松田良一、林　良雄
- Organizer
  創薬懇話会2014
- Place of Presentation
  岐阜
- Year and Date
  2014-07-10 – 2014-07-11
- Data Source
  KAKENHI-PUBLICLY-26102740

1. KISO Yoshiaki (40089107)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
2. KIMURA Tooru (70204980)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. YAMAZAKI Yuri (70459725)

# of Collaborated Projects: 3 results

# of Collaborated Products: 39 results
4. MIURA Masahiko (10272600)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
5. YAMAZAKI Toshimasa (40360458)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. YAMAGUCHI Akira (00142430)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 吉村亮一 (40302864)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. 戒田篤志 (40632097)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
9. 岡本裕之 (90595729)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 高山健太郎 (70611482)

# of Collaborated Projects: 1 results

# of Collaborated Products: 51 results
11. 田口晃弘 (40707311)

# of Collaborated Projects: 1 results

# of Collaborated Products: 80 results
12. 谷口敦彦 (30790125)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
13. 神谷亘 (60551421)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 今野翔 (70882190)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. KANGAWA Kenji

# of Collaborated Projects: 1 results

# of Collaborated Products: 18 results
16. MIYAZATO Mikiya

# of Collaborated Projects: 1 results

# of Collaborated Products: 18 results
17. MORI Kenji

# of Collaborated Projects: 1 results

# of Collaborated Products: 21 results
18. MINAMINO Naoto

# of Collaborated Projects: 1 results

# of Collaborated Products: 18 results
19. YAMAMOTO Akira

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
20. SAKANE Toshiyasu

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
21. TANAKA Akiko

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
22. NEGISHI Yoichi

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results
23. RENTIER CEDRIC

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
24. 山口宜秀

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 迫田秀之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. 大沢裕

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. 村上龍文

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. 砂田芳秀

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. 西松伸一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
30. 藤野雅広

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HAYASHI Yoshio 林 良雄

Research Projects

Research Products

Co-Researchers

Development of innovative drug discovery based on SARS-CoV-2 3CL protease inhibitor YH-53Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Synthesis and Medicinal Chemical Development of Mid-Sized Peptide Conjugate Based on the Chemistry of Solid-Phase Disulfide LigationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a ganma-tubulin targeting diketopiperazine and its study on chemical biologyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of myostatin inhibitory peptides for the treatment of muscle wasting disorderPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies on molecular functions of mid-size peptides derived from living system and their basic research for practical drug discoveryPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

天然由来ジペプチド様物質ネガマイシンを戦略分子とする創薬基盤研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of brachytherapy for early stage oral cancer using I-125 seeds

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Integrated medicinal chemistry research of intractable diseases based on peptidic small moleculesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Visualization of oral cancer microenvironment using molecular imaging and its application to radiotherapy

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study on Medicinal Chemistry of Reversible Cysteine Protease Inhibitors for the Treatment of Infectious DiseasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study on Medicinal Chemistry, Chemical Biology and Chemical Pharmaceutics of Anticancer Drug Based on the Microtubule Targeting AgentsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

化学療法による遺伝病克服への挑戦:デュシェンヌ型筋ジストロフィーの治療薬の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

腫瘍選択的血管内皮細胞障害物質フェニラヒスチンを戦略分子とする分子創薬基盤研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

HAYASHI Yoshio 林良雄