HIROAKI HIDEKAZU 廣明秀一

… Alternative Names

HIROAKI Hidekazu 廣明秀一

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Researcher Number	10336589
Other IDs
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Affiliation (Current)	2025: 名古屋大学, 創薬科学研究科, 教授
Affiliation (based on the past Project Information) *help	2024: 名古屋大学, 創薬科学研究科, 教授 2012 – 2019: 名古屋大学, 創薬科学研究科, 教授 2014 – 2016: 名古屋大学, その他の研究科, 教授 2011: 名古屋大学, 理学研究科, 教授 2010: 神戸大学, 医学研究科, 特命教授 … More 2009 – 2010: 神戸大学, 大学院・医学研究科, 特命教授 2008: Kobe University, 医学研究科, 特命教授 2007: Kobe University, 大学院・医学系研究科, 教授 2005: Yokohama City University, International Graduate School of Arts and Sciences, Ph.D., Associated Professor, 大学院・国際総合科学研究科, 準教授 2004: 横浜市立大学, 大学院・統合理学研究科, 助教授 2002 – 2004: 横浜市立大学, 大学院・総合理学研究科, 助教授 Less
Review Section/Research Field	Principal Investigator Biophysics / Structural biochemistry / Sections That Are Subject to Joint Review: Basic Section47010:Pharmaceutical chemistry and drug development sciences-related , Basic Section47050:Environmental and natural pharmaceutical resources-related / Basic Section 47050:Environmental and natural pharmaceutical resources-related / Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related / Molecular biology Except Principal Investigator Pathological medical chemistry / Structural biochemistry / Physical pharmacy / Biological Sciences / Biological Sciences
Keywords	Principal Investigator 細胞骨格 / 天然変性タンパク質 / PDZドメイン / 凍結保護 / MITドメイン / MIT domain / ドメイン解剖学 / エンドソーム / 短寿命タンパク質複合体 / インタラクトーム … More / 細胞内タンパク質近接アッセイ / タンパク質タンパク質相互作用阻害剤 / 選択的水和 / 分子クラウディング / 生体分子 / タンパク質 / アミロイド繊維形成 / 凝集抑制 / 温度依存性 / アミド水素 / 化学シフト / アミロイド線維 / 朝倉・大沢理論 / 高分子クラウディング / 分子夾雑 / 分子シールド効果 / 中分子創薬 / タンパク質間相互作用阻害剤 / アクチン / 細胞間接着装置 / 細胞骨格制御 / LIMキナーゼ / インシリコスクリーニング / NMRスクリーニング / タンパク質間相互作用 / DVL阻害剤 / 細胞形態変化 / トリプルネガティブ乳がん / Dishevelled阻害剤 / Wntシグナル伝達系 / タイトジャンクション / バリア強化剤 / 医薬品吸収促進剤 / グリチルリチン / フラボノイド / アントラニル酸 / ケミカルバイオロジー / タンパク質間相互作用阻害薬 / sequence identity / cell skeleton / tubulin / late endosome / protein domain anatomy / Nuclear magnetic resonance (NMR) / functional protein domains / X線結晶構造解析 / ペルオキシソーム / ポリユビキチン / プロテアソーム / 配列相同性 / チューブリン / 後期エンドソーム / 核磁気共鳴法(NMR) / 機能性タンパク質ドメイン / 国内優先権に基づく出願 / 医療応用 / 原著論文発表 / 再生・細胞医療 / 凍結保護剤 / バイオ医薬品安定化剤 / 国際特許出願 / 国内優先権による出願 / 医薬品添加剤 / 分子盾効果 / コールドチェイン / バイオ医薬品添加剤 / ヒストンフォールド / タウタンパク質 / ドミナントネガティブ変異体 / ESCRT-III複合体 / 微小管切断酵素 / AAAドメイン / マルチドメイン蛋白質 / 膜骨格 / 膜輸送 / AAA-ATPase / ATPase / マルチドメインタンパク質 / 分子認識及び相互作用 / タンパク質導入ドメイン / ランタニド結合タグ / マクロピノソーム / 細胞内小胞輸送 / バイオイメージング / タンパク質の巻き戻し / 人工シャペロン / PHドメイン / PXドメイン / 脂質結合ドメイン / PRESAT-vector / SH3 domain / PX domain / ホスファチジン酸 / ホスホリパーゼD … More Except Principal Investigator 脳神経疾患 / ナトリウムポンプ / 神経変性疾患 / 神経細胞死 / データベース / 立体構造 / NMR / モデリング / ホモロジーモデリング / ＮＭＲ / 自動解析 / 核磁気共鳴法 / 異常凝集体 / ペプチド創薬 / タンパク質ータンパク質相互作用 / アルツハイマー病 / 構造解析 / 蛋白質 / シグナル伝達 / 新規創薬ターゲット / 核酸医薬 / ヌクレオリン / 変性とフォールディング / 構造・機能予測 / バイオインフォマティクス / ユビキチン / ペロキシソーム / 細胞内輸送 / 生理活性ペプチド / G蛋白質共役受容体 / SUMO / 小胞輸送 / 膜蛋白質 / インターロイキン / X線結晶構造解析法 / 膜受容体 / 免疫 / 膜たんぱく質 / 結晶構造解析 Less

PDZ足場タンパク質の機能に介入する阻害剤ライブラリの構築と創薬応用Principal Investigator
- Principal Investigator
  
  廣明秀一
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
  Basic Section 47050:Environmental and natural pharmaceutical resources-related
  Sections That Are Subject to Joint Review: Basic Section47010:Pharmaceutical chemistry and drug development sciences-related , Basic Section47050:Environmental and natural pharmaceutical resources-related
- Research Institution
  Nagoya University
Propagation of Alzheimer's disease neuronal cell death by intracellular formation and secretion of abnormal aggregates
- Principal Investigator
  
  HOSHI Minako
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Foundation for Biomedical Research and Innovation at Kobe
Application of molecular shielding effect of intrinsically disordered proteins towards development of protein stabilizersPrincipal Investigator
- Principal Investigator
  
  HIROAKI Hidekazu
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Biophysics
- Research Institution
  Nagoya University
Dynamic mechanisms of regurating cell-cell junction and cell shape of epithelial cells unravelled by protein structure informationPrincipal Investigator
- Principal Investigator
  
  HIROAKI Hidekazu
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  Nagoya University
Development of NMR drug discovery pipeline using database
- Principal Investigator
  
  Kobayashi Naohiro
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  Osaka University
Elucidation of a neurodegenerative mechanism induced by a new Alzheimer's disease drug target and its inhibition
- Principal Investigator
  
  Hoshi Minako
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Foundation for Biomedical Research and Innovation
Medicinal application of intrinsically disordered proteins of unknown functionPrincipal Investigator
- Principal Investigator
  
  HIROAKI Hidekazu
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Biophysics
- Research Institution
  Nagoya University
ヌクレオリンによる核酸医薬のガン細胞特異的シャトル機構の解明
- Principal Investigator
  
  藤原芳江
- Project Period (FY)
  2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Osaka University
Synthetic and Structural Biology Approach for Understanding Mechanism of AAA-ATPasePrincipal Investigator
- Principal Investigator
  
  HIROAKI Hidekazu
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  Nagoya University
  Kobe University
Development and application of a database of intrinsic protein disorder
- Principal Investigator
  
  OTA Motonori
- Project Period (FY)
  2009 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Nagoya University
ランタニド結合配列を用いたエンドソーム・マクロピノソームの可視化Principal Investigator
- Principal Investigator
  
  廣明秀一
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Biophysics
- Research Institution
  Kobe University
Molecular basis of the adaptor domains from AAA-ATPases for locating organelles.Principal Investigator
- Principal Investigator
  
  HIROAKI Hidekazu
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biophysics
- Research Institution
  Yokohama City University
Structural study of signal transduction by membrane receptors through protein-protein interactions
- Principal Investigator
  
  SHIRAKAWA Masahiro
- Project Period (FY)
  2003 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
  Yokohama City University
ヒトホスホリパーゼDのドメイン解剖学による細胞シグナル伝達機構の研究Principal Investigator
- Principal Investigator
  
  廣明秀一
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Molecular biology
- Research Institution
  Yokohama City University

[Book] Chapter 21: Protein-ligand interactions studied by NMR, in “Experimental Approaches of NMR Spectroscopy ‐ Methodology and Application to Life Science and Materials Science”2018
- Author(s)
  Hiroaki Hidekazu、Daisuke Kohda
- Total Pages
  20
- Publisher
  Springer
- ISBN
  9789811059650
- Data Source
  KAKENHI-PROJECT-16K14707
[Book] In silico創薬におけるスクリーニングの高速化・効率化技術　第一章　第７節NMRによるin-silicoスクリーニング計算結果の検証2018
- Author(s)
  廣明秀一
- Total Pages
  30
- Publisher
  技術情報協会
- ISBN
  9784861046889
- Data Source
  KAKENHI-PROJECT-15H04337
[Book] Protein-Ligand Interactions Studied by NMR　（Experimental Approaches of NMR Spectroscopy ‐ Methodology and Application to Life Science and Materials Science）2017
- Author(s)
  Hiroaki Hidekazu、Kohda Daisuke
- Total Pages
  21
- Publisher
  Springer
- ISBN
  9789811059650
- Data Source
  KAKENHI-PROJECT-15H04337
[Book] Special Periodical Reports; Nuclear Magnetic Resonance Volume 452016
- Author(s)
  Hiroaki, H
- Total Pages
  22
- Publisher
  Royal Society of Chemistry
- Data Source
  KAKENHI-PROJECT-26650048
[Book] タンパク質の立体構造入門2010
- Author(s)
  太田元規, 廣明秀一, ら
- Total Pages
  182
- Publisher
  講談社
- Data Source
  KAKENHI-PLANNED-21113007
[Book] タンパク質の立体構造入門 (藤博幸編)2010
- Author(s)
  太田元規,廣明秀一, 他
- Total Pages
  182
- Publisher
  講談社
- Data Source
  KAKENHI-PLANNED-21113007
[Journal Article] Discovery of potent Dishevelled inhibitors using optimized virtual screening with NMR-based docking performance index.2018
- Author(s)
  Kiminori Hori, Kasumi Ajioka, Natsuko Goda, Asako Shido, Motoyuki Ito, Takeshi Tenno, and Hidekazu Hiroaki
- Journal Title
  
  Frontiers in Pharmacology
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04337
[Journal Article] Discovery of Cryoprotective Activity in Human Genome-Derived Intrinsically Disordered Proteins2018
- Author(s)
  Matsuo Naoki、Goda Natsuko、Shimizu Kana、Fukuchi Satoshi、Ota Motonori、Hiroaki Hidekazu
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 19 Issue: 2 Pages: 401-401
- DOI
  10.3390/ijms19020401
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K14707
[Journal Article] Common molecular pathogenesis of disease-related intrinsically disordered proteins revealed by NMR analysis2017
- Author(s)
  Shigemitsu Yoshiki、Hiroaki Hidekazu
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: 163 Issue: 1 Pages: 11-18
- DOI
  10.1093/jb/mvx056
- NAID
  40021457337
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K14707
[Journal Article] Common molecular pathogenesis of disease-related intrinsically disordered proteins revealed by NMR analysis2017
- Author(s)
  Y. Shigemitsu & H. Hiroaki.
- Journal Title
  
  J Biochemistry
  
  Volume: 印刷中
- NAID
  40021457337
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16K14707
[Journal Article] Nuclear magnetic resonance evidence for the dimer formation of beta amyloid peptide 1-42 in 1,1,1,3,3,3-hexafluoro-2-propanol.2016
- Author(s)
  Yoshiki Shigemitsu, Naoko Iwaya, Natsuko Goda, Mizuki Matsuzaki, Takeshi Tenno, Akihiro Narita, Minako Hoshi, Hidekazu Hiroaki
- Journal Title
  
  Analytical Biochemistry
  
  Volume: 498 Pages: 59-67
- DOI
  10.1016/j.ab.2015.12.021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-13J09612, KAKENHI-PROJECT-26650048, KAKENHI-PROJECT-26251017
[Journal Article] Application of NMR in Drug Discovery, (invited review)2016
- Author(s)
  Hidekazu Hiroaki
- Journal Title
  
  Special Periodical Reports; Nuclear Magnetic Resonance Volume 45 (Royal Society of Chemistry)
  
  Volume: 45 Pages: 217-239
- DOI
  10.1039/9781782624103-00217
- ISBN
  9781782620532
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04337
[Journal Article] Nuclear magnetic resonance evidence for the dimer formation of beta amyloid peptide 1-42 in 1,1,1,3,3,3-hexafluoro-2-propanol2016
- Author(s)
  Shigemitsu, Y., Iwaya, N., Goda, N., Matsuzaki, M., Tenno, T., Narita, A., Hoshi, M., 　　*Hiroaki, H.
- Journal Title
  
  Analytical Biochemistry
  
  Volume: 498 Pages: 59-67
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293075
[Journal Article] 用語解説「天然変性蛋白質」2015
- Author(s)
  廣明秀一
- Journal Title
  
  再生医療（日本再生医療学会雑誌）
  
  Volume: 14 Pages: 52-53
- Data Source
  KAKENHI-PROJECT-15H04337
[Journal Article] An optimized Npro-based method for the expression and purification of intrinsically disordered proteins for an NMR study.2015
- Author(s)
  Goda, N., Matsuo, N., Tenno, T., Ishino, S., Ishino, Y., Fukuchi, S., Ota, M., and Hiroaki, H
- Journal Title
  
  Intrinsically Disordere Proteins
  
  Volume: 3 Issue: 1 Pages: 1-6
- DOI
  10.1080/21690707.2015.1011004
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26650048
[Journal Article] 用語解説：天然変性タンパク質2015
- Author(s)
  廣明秀一
- Journal Title
  
  日本再生医療学会雑誌-再生医療
  
  Volume: 13 Pages: 52-53
- Data Source
  KAKENHI-PROJECT-26650048
[Journal Article] Crystal structure of afadin PDZ domain-nectin-3 complex shows the structural plasticity of the ligand-binding site.2015
- Author(s)
  Fujiwara Y, Goda N, Tamashiro T, Narita H, Satomura K, Tenno T, Nakagawa A, Oda M, Suzuki M, Sakisaka T, Takai Y, Hiroaki H.
- Journal Title
  
  Protein Sci.
  
  Volume: 24 Issue: 3 Pages: 376-385
- DOI
  10.1002/pro.2628
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21227005, KAKENHI-PROJECT-25293071, KAKENHI-PLANNED-26114007, KAKENHI-PUBLICLY-26117513, KAKENHI-PROJECT-26251013, KAKENHI-PROJECT-26440028, KAKENHI-PROJECT-15H04337
[Journal Article] 用語解説：天然変性タンパク質2015
- Author(s)
  廣明秀一
- Journal Title
  
  日本再生入用学会雑誌-再生医療
  
  Volume: 13
- Data Source
  KAKENHI-PROJECT-26650048
[Journal Article] A Method for Systematic Assessment of Intrinsically Disordered Protein Regions by NMR2015
- Author(s)
  Goda, N., Shimizu, K., Kuwahara, Y., Tenno, T., Noguchi,T., Ikegami, T., Ota, M., and Hiroaki, H
- Journal Title
  
  Intternational Journal of Molecular Sciences
  
  Volume: 16 Issue: 7 Pages: 15743-15760
- DOI
  10.3390/ijms160715743
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26650048
[Journal Article] IDEAL in 2014 illustrates interaction networks composed of intrinsically disordered proteins and their binding partners2014
- Author(s)
  Fukuchi, S., Amemiya, T., Sakamoto, S., Nobe, Y., Hosoda, K., Kado, Y., Murakami, S.D., Koike, R., Hiroaki, H., and Ota, M.
- Journal Title
  
  Nucleic Acids Res.
  
  Volume: 42 Issue: D1 Pages: D320-D325
- DOI
  10.1093/nar/gkt1010
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-21113001, KAKENHI-PLANNED-21113007
[Journal Article] Multiple Interactions of the Intrinsically Disordered Region between the N-terminal Helicase and C-terminal Nuclease Domains2014
- Author(s)
  S. Ishino, T. Yamagami, M. Kitamura, N. Kodera, T. Mori, S. Sugiyama, T. Ando, N. Goda, T. Tenno, H. Hiroaki, and Y. Ishino
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 289 Issue: 31 Pages: 21627-21639
- DOI
  10.1074/jbc.m114.554998
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24227005, KAKENHI-PROJECT-24770149, KAKENHI-PROJECT-26242075, KAKENHI-PROJECT-26650048
[Journal Article] MIT domain of Vps4 is a Ca^<2+>-dependent phosphoinositide-binding domain2013
- Author(s)
  Naoko Iwaya, Hirotoshi Takasu, Natsuko Goda, Masahiro Shirakawa, Toshiki Tanaka, Daizo Hamada, Hidekazu Hiroaki
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: 153巻 Issue: 5 Pages: 473-481
- DOI
  10.1093/jb/mvt012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-13J09612, KAKENHI-PLANNED-21113007, KAKENHI-PROJECT-22570118, KAKENHI-PROJECT-23570193
[Journal Article] MIT domain of Vps4 is a Ca^2+-dependent phosphoinositide-binding domain.2013
- Author(s)
  Iwaya, N., Takasu, H., Goda, N., Shirakawa, M., Tanaka, T., Hamada, D., and Hiroaki, H*.
- Journal Title
  
  J. Biochem.
  
  Volume: 153(5) Pages: 473-481
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570118
[Journal Article] Recent applications of isotopic labeling for protein NMR in drug discovery. invited review2013
- Author(s)
  Hiroaki, H* (Hiroaki, H.)
- Journal Title
  
  Expert Opinion on Drug Discovery
  
  Volume: 8 Issue: 5 Pages: 523-536
- DOI
  10.1517/17460441.2013.779665
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570118
[Journal Article] An assignment of intrinsically disordered regions of proteins based on NMR structures.2013
- Author(s)
  Ota, M*., Koike, R., Amemiya, T., Tenno, T., Romero, P.R., Hiroaki, H., Dunker, A.K., and Fukuchi, S.
- Journal Title
  
  J Structural Biol
  
  Volume: 181 Pages: 29-36
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570118
[Journal Article] An assignment of intrinsically disordered regions of proteins based on NMR structures2013
- Author(s)
  M.Ota, H.Hiroaki, S.Fukuchi, et al.
- Journal Title
  
  J. Struct. Biol.
  
  Volume: 181巻 Issue: 1 Pages: 29-36
- DOI
  10.1016/j.jsb.2012.10.017
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21113007
[Journal Article] IDEAL - Intrinsically Disordered proteins with Extensive Annotations and Literature.2012
- Author(s)
  Fukuchi, S*., Sakamoto, S., Nobe, Y., Murakami, D. S., Amemiya, T., Hosoda, K., Koike, R. Hiroaki, H., and Ota, M*.
- Journal Title
  
  Nucleic Acids Research (database issue)
  
  Volume: 40 (1)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570118
[Journal Article] IDEAL : intrinsically disordered proteins with extensive annotations and literature2012
- Author(s)
  S.Fukuchi.H.Hiroaki, M.Ota, et al.
- Journal Title
  
  Nucleic Acids Res.
  
  Volume: 40巻 Issue: D1 Pages: D507-D511
- DOI
  10.1093/nar/gkr884
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21113007, KAKENHI-PROJECT-22570118
[Journal Article] Effect of Ca^2+ on microtubule severing enzyme katanin p60; insight into the substrate dependent activation mechanism.2012
- Author(s)
  Iwaya, N., Akiyama, K., Goda, N., Tenno, T., Fujiwara, Y., Hamada, D., Ikura, T., Shirakawa, M., and Hiroaki, H*.
- Journal Title
  
  FEBS J
  
  Volume: 279 Pages: 1339-1352
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570118
[Journal Article] Effect of Ca^<2+> on microtubule severing enzyme katanin p60 ; insight into the substrate dependent activation mechanism2012
- Author(s)
  N.Iwaya, et al
- Journal Title
  
  FEBS J.
  
  Volume: 279 Issue: 7 Pages: 1339-1352
- DOI
  10.1111/j.1742-4658.2012.08528.x
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21113007, KAKENHI-PLANNED-21121006, KAKENHI-PROJECT-22570118, KAKENHI-PUBLICLY-23107721, KAKENHI-PROJECT-23570193
[Journal Article] Structure and function of the N-terminal nucleolin binding domain of nuclear Valocin containing protein like 2 (NVL2) harboring a nucleolar localization signal2011
- Author(s)
  Y.Fujiwara, et al
- Journal Title
  
  J Biol Chem
  
  Volume: 286 Issue: 24 Pages: 21732-21741
- DOI
  10.1074/jbc.m110.174680
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21113007, KAKENHI-PLANNED-21121006, KAKENHI-PROJECT-22570118, KAKENHI-PROJECT-23590042
[Journal Article] A Simplified Recipe for Assigning Amide NMR Signals Using Combinatorial 14N Amino Acid Inverse-Labeling.2011
- Author(s)
  Hiroaki, H*., Umetsu, Y., Hoshi, M., Nabeshima, Y. and Kohda, D.
- Journal Title
  
  J Structural Functional Genomics
  
  Volume: 12 (3) Pages: 167-174
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570118
[Journal Article] A Simplified Recipe for Assigning Amide NMR Signals Using Combinatorial 14N Amino Acid Inverse-Labeling2011
- Author(s)
  H.Hiroaki, et al.
- Journal Title
  
  J Structural Functional Genomics.
  
  Volume: 12巻 Issue: 3 Pages: 167-174
- DOI
  10.1007/s10969-011-9116-0
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21113007, KAKENHI-PROJECT-22570118
[Journal Article] Structure and function of the N-terminal nucleolin binding domain of nuclear Valocin containing protein like 2 (NVL2) harboring a nucleolar localization signal2011
- Author(s)
  Fujiwara, Y., Fujiwara, K., Goda, N., Iwaya, N., Tenno, T., Shirakawa, M., Hiroaki, H*.
- Journal Title
  
  J Biol Chem
  
  Volume: 286 (24) Pages: 21732-21741
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570118
[Journal Article] Crystal structure of a PFU-PUL domain pair of Saccharomyces cerevisiae Doa1/Ufd3.2010
- Author(s)
  Nishimasu, R., Komori, H., Higuchi, Y., Nishimasu, H., Hiroaki, H.
- Journal Title
  
  Kobe Journal of Medical Sciences
  
  Volume: 56
- NAID
  110009824994
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570118
[Journal Article] SAHG, a comprehensive database of predicted structures of all human proteins.2010
- Author(s)
  Motono, C., Hiroaki, H., Ota, M, 他
- Journal Title
  
  Nucleic Acids Research
  
  Volume: 39 (suppl 1)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570118
[Journal Article] Structure and mutagenesis studies of the C-terminal region of licensing factor Cdt1 enable the identification of key residues for binding to replicative helicase Mcm proteins.2010
- Author(s)
  Jee, J., Mizuno, T., Kamada, K., Tochio, H., Chiba, Y., Yanagi, K., Yasuda, G., Hiroaki, H., Hanaoka, F., and Shirakawa, M.
- Journal Title
  
  J Biol Chem
  
  Volume: 285 Pages: 15931-15940
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570118
[Journal Article] A common substrate recognition mode conserved between katanin p60 and VPS4 governs microtubule severing and membrane skeleton reorganization.2010
- Author(s)
  Iwaya, N., Kuwahara, Y., Fujiwara, Y., Goda, N., Tenno, T., Hiroaki, H., 他
- Journal Title
  
  Jounrnal of Biologicl Chemistry
  
  Volume: 285 Pages: 16822-16829
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570118
[Journal Article] Structure and mutagenesis studies of the C-terminal region of licensing factor Cdt1 enable the identification of key residues for binding to replicative helicase Mcm proteins.2010
- Author(s)
  Jee, J., Hiroaki, H., Hanaoka, F., Shirakawa, M, 他
- Journal Title
  
  Jounrnal of Biologicl Chemistry
  
  Volume: 285 Pages: 15931-15940
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570118
[Journal Article] SAHG, a comprehensive database of predicted structures of all human proteins.2010
- Author(s)
  Motono, C., Nakata, J., Koike, R., Shimizu, K., Shirota, M., Amemiya, T., Tomii, K., Nagano, N., Sakaya, N., Misoo, K., Sato, M., Kidera, A., Hiroaki, H., Shirai, T., Kinoshita, K., Noguchi, T., and Ota, M.
- Journal Title
  
  Nucleic Acids Res
  
  Volume: 39(suppl 1)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570118
[Journal Article] A common substrate recognition mode conserved between katanin p60 and VPS4 governs microtubule severing and membrane skeleton reorganization.2010
- Author(s)
  Iwaya, N., Kuwahara, Y., Fujiwara, Y., Goda, N., Tenno, T., Akiyama, K., Mase, S., Tochio, H., Ikegami, T., Shirakawa, M., and Hiroaki, H*.
- Journal Title
  
  J Biol Chem
  
  Volume: 285 Pages: 16822-16829
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570118
[Journal Article] High-resolution multi-dimensional NMR spectroscopy of proteins in human cells2009
- Author(s)
  Inomata, R., Ohno, A., Tochio, H. Isogai, S., Tenno, T., Maltase, I., Takeuchi, T., Futaki, S., Ito, Y., Hiroaki, H, and Shirakawa
- Journal Title
  
  Nature 458
  
  Pages: 106-109
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15083102
[Journal Article] High-resolution multi-dimensional NMR spectroscopy of proteins in human cells.2009
- Author(s)
  Inomata, K., Ohno, A., Tochio, H., Isogai, S., Tenno, T., Nakase, I., Takeuchi, T., Futaki, S., Ito, Y., Hiroaki, H, and Shirakawa, M.
- Journal Title
  
  Nature 458
  
  Pages: 106-109
- Data Source
  KAKENHI-PROJECT-15083102
[Journal Article] Kinetic and Thermodynamic evidence for flipping of amethyl-CpG binding domain on methylated DNA.2008
- Author(s)
  Inomata, K., Ohki, I., Tochio, H., Fujiwara, K., Hiroaki, H., Shirakawa, M.
- Journal Title
  
  Biochemistry 47
  
  Pages: 3216-3271
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15083102
[Journal Article] The solution structure .of the C-terminal domain of NfeD reveals a novel membrane-anchored OB-fold2008
- Author(s)
  Kuwahara, Y., Ohno, A., Morii, T., Yokoyama, H., Matsui, I., Tochio, H., Shirakawa, M., and Hiroaki, H.
- Journal Title
  
  Protein Science 17
  
  Pages: 1915-1924
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15083102
[Journal Article] Intracellular protein delivery activity of peptides derived from insulin-like growth factor binding proteins 3 and 52008
- Author(s)
  Goda, Tenno, T., Inomata, K., Shirakawa, M., Tanaka, T., Hiroaki, H.
- Journal Title
  
  Experimental Cell Research 314
  
  Pages: 2352-2361
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15083102
[Journal Article] The solution structure of the C-terminal domain of NfeD reveals a novel membrane-anchored OB-fold.2008
- Author(s)
  Kuwahara, Y., Ohno, A., Morii, T., Yokoyama, H., Matsui, I., Tochio, H., Shirakawa, M., and Hiroaki, H.
- Journal Title
  
  Protein Science 17
  
  Pages: 1915-1924
- Data Source
  KAKENHI-PROJECT-15083102
[Journal Article] 進むGPCRの立体構造解析…展望と課題2008
- Author(s)
  天野剛志・廣明秀一
- Journal Title
  
  蛋白質核酸酵素 53
  
  Pages: 256-264
- Data Source
  KAKENHI-PROJECT-19657048
[Journal Article] Kinetic and Thermodynamic evidence for flipping of a methyl-CpG binding domain on methylated DNA.2008
- Author(s)
  Inomata, K., Ohki, I., Tochio, H., Fujiwara, K., Hiroaki, H., Shirakawa, M.
- Journal Title
  
  Biochemistry 47
  
  Pages: 3266-3271
- Data Source
  KAKENHI-PROJECT-15083102
[Journal Article] Intracellular protein delivery activity of peptides derived from insulin-like growth factor binding proteins 3 and 5.2008
- Author(s)
  Goda, N., Tenno, T., Inomata, K., Shirakawa, M., Tanaka, T., Hiroaki, H.
- Journal Title
  
  Experimental Cell Research 314
  
  Pages: 2352-2361
- Data Source
  KAKENHI-PROJECT-15083102
[Journal Article] LBT/PTD dual tagged vector for purification, cellular protein delivery and visualization in living cells.2007
- Author(s)
  Goda, N., Tenno, T., Inomata, K., Iwaya, N., Sasaki, Y., Shirakawa, M., Hiroaki, H.
- Journal Title
  
  Biochemica et Biophysica Acta 1773
  
  Pages: 141-146
- Data Source
  KAKENHI-PROJECT-15083102
[Journal Article] LBT/PTD dual tagged vector for purification, intrtacellular protein delivery and visualization in living cells. BBA-Mol Cell Res 1773 141-146.(2007).2007
- Author(s)
  合田名都子、天野剛志、猪股浩介、佐々木慶之、白川昌宏、廣明秀一
- Journal Title
  
  Biochimica et Biophysica Acta-Molecular Cell Research 1773
  
  Pages: 141-146
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19657048
[Journal Article] Fluoroscopic assessment of protein leakage during Xenopusoocytes in-cell NMR experiment by co-injected EGFP.2007
- Author(s)
  Sakai, T., Tochio, H., Inomata, K., Sasaki, Y., Tenno, T., Tanaka, T., Kokubo, T., Hiroaki, H., Shirakawa, M.
- Journal Title
  
  Analytical Biochemistry 371
  
  Pages: 247-249
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15083102
[Journal Article] Fluoroscopic assessment of protein leakage during Xenopus oocytes in-cell NMR experiment by co-injected EGFP.2007
- Author(s)
  Sakai, T., Tochio, H., Inomata, K., Sasaki, Y., Tenno, T., Tanaka, T., Kokubo, T., Hiroaki, H., Shirakawa, M.
- Journal Title
  
  Analytical Biochemistry 371
  
  Pages: 247-249
- Data Source
  KAKENHI-PROJECT-15083102
[Journal Article] Fine-tuning of protein domain boundary by minimizing potential coiled coil regions.2007
- Author(s)
  Iwaya, N., Goda, N., Unzai, S., Fujiwara, K., Tanaka, T., Tomii, K., Tochio, H., Shirakawa, M., Hiroaki, H.
- Journal Title
  
  Journal of biomolecular NMR 37
  
  Pages: 53-63
- Data Source
  KAKENHI-PROJECT-15083102
[Journal Article] Fine-tuning of protein domain boundary by minimizing potential coiled coil regions.2007
- Author(s)
  Iwaya, N., Goda, N., Unzai, S., Fujiwara, K., Tanaka, T., Tomii, K., Tochio, H., Shirakawa, M. and Hiroaki, H.
- Journal Title
  
  Journal of biomolecular NMR 37
  
  Pages: 53-63
- Data Source
  KAKENHI-PROJECT-15083102
[Journal Article] Crystal structure of SUMO-3-modified thymine-DNA glycosylase.2006
- Author(s)
  Baba, D., Maita; N., Jee, J.-G., Uchimura, Y., Saitoh, H., Sugasawa, K., Hanaoka, F., Tochio, H., Hiroaki, H, Shirakawa, M.
- Journal Title
  
  Journal of Molecular Biology 359
  
  Pages: 137-147
- Data Source
  KAKENHI-PROJECT-15083102
[Journal Article] In-Cell NMR Spectroscopy of Proteins inside Xenopus laevis Oocytes.2006
- Author(s)
  Sakai, T., Tochio, H., Tenno, T., Ito, Y., Kokubo, T., Hiroaki, H., Shirakawa, M.
- Journal Title
  
  Journal of biomolecular NMR 36
  
  Pages: 179-188
- Data Source
  KAKENHI-PROJECT-15083102
[Journal Article] In-Cell NMR Spectroscopy of Proteins inside Xenopus laevis Oocytes.2006
- Author(s)
  Sakai, T., Tochio, H., Tenno, T., Ito, Y., Kokubo, T., Hiroaki, H. and Shirakawa, M.
- Journal Title
  
  Journal of biomolecular NMR 36
  
  Pages: 179-188
- Data Source
  KAKENHI-PROJECT-15083102
[Journal Article] ペルオキシソーム因子PEX1 ATPaseのN末端ドメインの立体構造が示したAAA ATPase間の進化的類縁関係2006
- Author(s)
  廣明秀一, 塩澤久美子, 富井健太郎
- Journal Title
  
  生物物理 46(3)
  
  Pages: 159-163
- NAID
  110004750171
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16570136
[Journal Article] The Structure of N-terminal Domain from PEX1 Reveals Its Evolutionary Relationship to Type II AAA-ATPases2006
- Author(s)
  Shiozawa, K., Tomii, K., Hiroaki, H^*
- Journal Title
  
  SEIBUTSUBUTSURI (Biophysics, Jpn.Ed.) 46
  
  Pages: 159-163
- NAID
  110004750171
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16570136
[Journal Article] ペルオキシソーム因子PEX1 ATPaseのN末端ドメインの立体構造が示したAAA ATPase間の進化的類縁関係2006
- Author(s)
  廣明秀一, 塩澤久美子, 富井健太郎
- Journal Title
  
  生物物理 46(3)(印刷中)
- NAID
  110004750171
- Data Source
  KAKENHI-PROJECT-16570136
[Journal Article] Crystal Structure of thymine DNA glycosylase conjugated to SUMO-12005
- Author(s)
  Baba, D., Maita, N., Jee, J.-G., Uchimura Y.Saitoh H., Sugasawa, K., Hanaoka, F..Tochio, H., Hiroaki, H., Shirakawa, M.
- Journal Title
  
  Nature 435
  
  Pages: 979-982
- Data Source
  KAKENHI-PROJECT-15083102
[Journal Article] Crystal Structure of thymine DNA glycosylase conjugated to SUMO-1.2005
- Author(s)
  Baba, D., Maita, N., Jee, J.-G., Uchimura, Y., Saitoh, H., Sugasawa, K., Hanaoka, F., Tochio, H., Hiroaki, H., Shirakawa, M.
- Journal Title
  
  Nature 435
  
  Pages: 979-982
- Data Source
  KAKENHI-PROJECT-15083102
[Journal Article] Continuous Designed Cation-pi Interactions Increase the Thermal Stability of an α-Helical Coiled-coil.2005
- Author(s)
  Sakurai, Y., Mizuno, T., Hiroaki, H., Gohda, K., Oku, J.I., Tanaka, T^*.
- Journal Title
  
  Angewandte Chem Int Ed. 44
  
  Pages: 6180-6183
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16570136
[Journal Article] Structure of the UBA domain of Dsk2p in complex with Ubiquitin : Molecular Determinants for Ubiquitin Recognition.2005
- Author(s)
  Ohno, A., Jee, J., Fujiwara, K., Tenno, T., Goda, N., Tochio, H., Kobayashi, H., Hiroaki, H..Shirakawa, M^*.
- Journal Title
  
  Structure 13
  
  Pages: 1-12
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16570136
[Journal Article] Structural characterization of the MIT domain from human Vps4b.2005
- Author(s)
  Takasu, H., Jee, J. G., Ohno, A., Goda, N., Fujiwara, K., Tochio, H., Shirakawa, M., and Hiroaki, H.
- Journal Title
  
  Biochemical and Biophysical Research Communications 334
  
  Pages: 460-465
- Data Source
  KAKENHI-PROJECT-15083102
[Journal Article] Structural characterization of the MIT domain from human Vps4b.2005
- Author(s)
  Takasu, H., Jee, J.G., Ohno, A., Goda, N., Fujiwara, K., Tochio, H., Shirakawa, M., Hiroaki, H^*
- Journal Title
  
  Biochemistry Biophysics Research Communnication 334
  
  Pages: 460-465
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16570136
[Journal Article] Structural characterization of the MIT domain from human Vps4b.2005
- Author(s)
  Takasu, H., Jee, J.G., Ohno, A., Goda, N., Fujiwara, K., Tochio, H., Shirakawa, M., Hiroaki H^*.
- Journal Title
  
  Biochem Biophys Res Commun. 334
  
  Pages: 460-465
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16570136
[Journal Article] Structure of the UBA domain of Dsk2p in complex with Ubiquitin : Molecular Determinants for Ubiquitin Recognition.2005
- Author(s)
  Ohno, A., Jee, J., Fujiwara, K., Tenno, T., Goda, N., Tochio, H., Kobayashi, H., Hiroaki, H., Shirakawa, M^*
- Journal Title
  
  Structure 13
  
  Pages: 1-12
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16570136
[Journal Article] Continuous Designed Cation-pi Interactions Increase the Thermal Stability of an α-Helical Coiled-coil.2005
- Author(s)
  Sakurai, Y., Mizuno, T., Hiroaki, H., Gohda, K., Oku, J.I., Tanaka, T^*.
- Journal Title
  
  Angewandte Chemie International Edition 44
  
  Pages: 6180-6183
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16570136
[Journal Article] Structure of the UBA domain of Dsk2p in complex with Ubiquitin : Molecular Determinants for Ubiquitin Recognition2005
- Author(s)
  Ohno, A., Jee J-G, Fujiwara, K., Tenno, T., Goda, N., Tochio, H., Kobayashi, H., Hiroaki, H., Shirakawa, M.
- Journal Title
  
  Structure 13
  
  Pages: 521-532
- Data Source
  KAKENHI-PROJECT-15083102
[Journal Article] Continuous Designed Cation-pi Interactions Increase the Thermal Stability of an α-Helical Coiled-coil.2005
- Author(s)
  Sakurai, Y., Mizuno, T., Hiroaki, H., Gohda, K., Oku, J.I., Tanaka, T^*.
- Journal Title
  
  Angewandte Chem Int Ed 44
  
  Pages: 6180-6183
- Data Source
  KAKENHI-PROJECT-16570136
[Journal Article] Structural characterization of the MIT domain from human Vps4b.2005
- Author(s)
  Takasu, H., Jee, J.G., Ohno, A., Goda, N., Fujiwara, K., Tochio, H., Shirakawa, M., Hiroaki, H^*
- Journal Title
  
  Biochem Biophys Res Commun 334
  
  Pages: 460-465
- Data Source
  KAKENHI-PROJECT-16570136
[Journal Article] Optimization of size complementary of the aromatic side chain in the hydrophobic core of the designed coiled-coil.2005
- Author(s)
  Sakurai, Y., Mizuno, T., Hiroaki H., Oku, J.I., Tanaka, T^*
- Journal Title
  
  J Pept Res 66
  
  Pages: 387-394
- Data Source
  KAKENHI-PROJECT-16570136
[Journal Article] Structural characterization of the MIT domain from human Vps4b.2005
- Author(s)
  Takasu, H., Jee, J.G., Ohno, A., Goda, N., Fujiwara, K., Tochio, H., Shirakawa, M., Hiroaki, H.
- Journal Title
  
  Biochemical and Biophysical Research Communications 334
  
  Pages: 460-465
- Data Source
  KAKENHI-PROJECT-15083102
[Journal Article] Structural basis for distinct roles of Lys63- and Lys48-linked polyubiquitin chains.2004
- Author(s)
  Tenno, T., Fujiwara, K., Tochio, H., Iwai, K., Morita, E.H., Hayashi, H., Murata, S., Hiroaki, H., Sato, M., Tanaka, K., Shirakawa, M^*.
- Journal Title
  
  Genes to Cells 9
  
  Pages: 865-875
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16570136
[Journal Article] Structural basis for distinctroles of Lys63- and Lys48-linked polyubiquitin chains.2004
- Author(s)
  Tenno, T., Fujiwara, K., Tochio, H., Iwai, K., Morita, E.H., Hayashi, H., Murata, S., Hiroaki, H., Sato, M., Tanaka, K., Shirakawa, M.
- Journal Title
  
  Genes to Cells 9
  
  Pages: 865-875
- Data Source
  KAKENHI-PROJECT-15083102
[Journal Article] Structure of the N-terminal domain of PEX1 AAA-ATPase : characterization of a putative adaptor-binding domain.2004
- Author(s)
  Shiozawa, K., Maita, N., Tomii, K., Seto, A., Goda, N., Tochio, H., Akiyama, Y., Shimizu, T., Shirakawa, M., Hiroaki, H^*.
- Journal Title
  
  J Biol Chem. 279
  
  Pages: 50060-50068
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16570136
[Journal Article] Structural basis for distinct roles of Lys63- and Lys48-linked polyubiquitin chains.2004
- Author(s)
  Tenno T, Fujiwara K, Tochio H, Iwai K, Morita EH, Hayashi H, Murata S, Hiroaki H, Sato M, Tanaka K, Shirakawa M.
- Journal Title
  
  Genes Cells. 9(10)
  
  Pages: 865-875
- Data Source
  KAKENHI-PROJECT-16570136
[Journal Article] Structural basis for distinct roles of Lys63- and Lys48-linked polyubiquitin chains.2004
- Author(s)
  Tenno T, Fujiwara K, Tochio H, Iwai K, Morita EH, Hayashi H, Murata S, Hiroaki H, Sato M, Tanaka K, Shirakawa M.
- Journal Title
  
  Genes to Cells. 9(10)
  
  Pages: 865-875
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16570136
[Journal Article] Crystallographic characterization of the N-terminal domain of PEX12004
- Author(s)
  Shiozawa, K., Maita, N., Tomii, K., Seto, A., Goda, N., Akiyama, Y., Shimizu, T., Shirakawa, M., Hiroaki, H.
- Journal Title
  
  Acta Crystallography D Biological Crystallography 60
  
  Pages: 2098-2099
- Data Source
  KAKENHI-PROJECT-15083102
[Journal Article] A vector suited to high-throughput expression of isotopically-labeled peptides.2004
- Author(s)
  Tenno, T., Goda, N., Tateishi, Y., Tochio, H., Mishima, M., Hayashi, H., Shirakawa, M., Hiroaki, H^*.
- Journal Title
  
  Protein Eng Design Sel. 17
  
  Pages: 305-304
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16570136
[Journal Article] Crystallographic characterization of the N-terminal domain of PEX1.2004
- Author(s)
  Shiozawa K, Maita N, Tomii K, Seto A, Goda N, Akiyama Y, Shimizu T, Shirakawa M, Hiroaki H.
- Journal Title
  
  Acta Crystallogr D Biol Crystallogr. 60(11)
  
  Pages: 2098-2099
- Data Source
  KAKENHI-PROJECT-16570136
[Journal Article] Structure of the N-terminal domain of PEX1 AAA-ATPase. Characterization of a putative adaptor-binding domain.2004
- Author(s)
  Shiozawa K, Maita N, Tomii K, Seto A, Goda N, Akiyama Y, Shimizu T, Shirakawa M, Hiroaki H.
- Journal Title
  
  J Biol Chem. 279(48)
  
  Pages: 50060-50068
- Data Source
  KAKENHI-PROJECT-16570136
[Journal Article] High-throughput construction method for expression vector of peptides for NMR study suited for isotopic labeling.2004
- Author(s)
  Tenno T, Goda N, Tateishi Y, Tochio H, Mishima M, Hayashi H, Shirakawa M, Hiroaki H.
- Journal Title
  
  Protein Engineering Design and Selection. 17(4)
  
  Pages: 305-314
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16570136
[Journal Article] High-throughput construction method for expression vector of peptides for NMR study suited for isotopic labeling.2004
- Author(s)
  Tenno T, Goda N, Tateishi Y, Tochio H, Mishima M, Hayashi H, Shirakawa M, Hiroaki H.
- Journal Title
  
  Protein Eng Des Sel. 17(4)
  
  Pages: 305-314
- Data Source
  KAKENHI-PROJECT-16570136
[Journal Article] Structure of the N-terminal domain of PEX1 AAA-ATPase : characterization of a putative adaptor-binding domain2004
- Author(s)
  Shiozawa, K.Maita, N., Tomii, K, Seto, A., Goda, N., Akiyama, Y., Shimizu, T., Shirakawa, M., Hiroaki, H.
- Journal Title
  
  Journal of Biological Chemistry 279
  
  Pages: 50060-50068
- Data Source
  KAKENHI-PROJECT-15083102
[Journal Article] Crystallographic characterization of the N-terminal domain of PEX1.2004
- Author(s)
  Shiozawa K, Maita N, Tomii K, Seto A, Goda N, Akiyama Y, Shimizu T, Shirakawa M, Hiroaki H.
- Journal Title
  
  Acta Crystallography D, Biological Crystallography. 60(11)
  
  Pages: 2098-2099
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16570136
[Journal Article] Crystallographic characterization of the N-terminal domain of PEX1.2004
- Author(s)
  Shiozawa, K., Maita, N., Tomii, K., Seto, A., Goda, N., Tochio, H., Akiyama, Y., Shimizu, T., Shirakawa, M., Hiroaki, H^*.
- Journal Title
  
  Acta Crystallogr D Biol Crystallogr. 60
  
  Pages: 2098-2099
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16570136
[Journal Article] Structure of the N-terminal domain of PEX1 AAA-ATPase. Characterization of a putative adaptor-binding domain.2004
- Author(s)
  Shiozawa K, Maita N, Tomii K, Seto A, Goda N, Akiyama Y, Shimizu T, Shirakawa M, Hiroaki H.
- Journal Title
  
  Journal of Biological Chemistry. 279(48)
  
  Pages: 50060-50068
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16570136
[Journal Article] High-throughput expression vector of isotopically labeled peptides for use in NMR studies2004
- Author(s)
  Tenno, T., Goda, N., Tateishi, Y., Tochio, H., Mishima, M., Shirakawa, M., Hiroaki, H.
- Journal Title
  
  Protein Engineering, Design & Selection 17
  
  Pages: 305-314
- Data Source
  KAKENHI-PROJECT-15083102
[Journal Article] Structural basis for the multiple interactions of the MyD88 TIR domain in TLR4 signaling.
- Author(s)
  Ohnishi, H., Tochio, H., Kato, Z., Orii, K., Li, A., Kimura, T., Hiroaki,H., Kondo, N., and Shirakawa, M.
- Journal Title
  
  Proceedings of the National Academy of Science (in press)
- Data Source
  KAKENHI-PROJECT-15083102
[Journal Article] Structure of the UBA domain of Dsk2p in complex with Ubiquitin : Molecular Determinants for Ubiquitin Recognition
- Author(s)
  Ohno, A., Jee, J-G, Fujiwara, K., Tenno, T., Goda, N., Tochio, H., Kobayashi, H., Hiroaki, H., Shirakawa, M.
- Journal Title
  
  Structure (印刷中)
- Data Source
  KAKENHI-PROJECT-15083102
[Journal Article] Recent applications of isotopic labeling for protein NMR in drug discovery
- Author(s)
  Hiroaki, H*.
- Journal Title
  
  Expert Opinion on Drug Discovery
  
  Volume: 8(5) Pages: 523-536
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570118
[Patent] 特許2017
- Inventor(s)
  廣明秀一、天野剛志、進藤麻子、高岸麻紀、堀公則
- Industrial Property Rights Holder
  名古屋大学
- Industrial Property Rights Type
  特許
- Filing Date
  2017
- Data Source
  KAKENHI-PROJECT-15H04337
[Patent] タイトジャンクションの緩和剤、該緩和剤を含む薬剤吸収補助剤、及び該緩和剤を含む医薬組成物2016
- Inventor(s)
  廣明秀一　天野剛志　野田翔太
- Industrial Property Rights Holder
  名古屋大学
- Industrial Property Rights Type
  特許
- Filing Date
  2016-05-24
- Overseas
- Data Source
  KAKENHI-PROJECT-15H04337
[Patent] タイトジャンクション形成制御剤及び該制御剤を含む医薬組成物2015
- Inventor(s)
  廣明秀一　天野剛志　中倉由香子　野田翔太
- Industrial Property Rights Holder
  名古屋大学
- Industrial Property Rights Type
  特許
- Filing Date
  2015-07-22
- Overseas
- Data Source
  KAKENHI-PROJECT-15H04337
[Patent] タンパク質凍結保存用保護剤2015
- Inventor(s)
  廣明秀一　天野名都子　松尾直紀　太田元規　福地佐斗志　岩村佳奈
- Industrial Property Rights Holder
  国立大学法人名古屋大学他
- Industrial Property Rights Type
  特許
- Filing Date
  2015-01-06
- Overseas
- Data Source
  KAKENHI-PROJECT-26650048
[Patent] タイトジャンクションの緩和剤、該緩和剤を含む薬剤吸収補助剤、及び該緩和剤を含む医薬組成物2015
- Inventor(s)
  廣明秀一　天野剛志　野田翔太
- Industrial Property Rights Holder
  名古屋大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2015-106881
- Filing Date
  2015-05-26
- Data Source
  KAKENHI-PROJECT-15H04337
[Patent] タンパク質凍結保存用保護剤2014
- Inventor(s)
  廣明秀一ら
- Industrial Property Rights Holder
  廣明秀一ら
- Industrial Property Rights Type
  特許
- Filing Date
  2014-02-24
- Data Source
  KAKENHI-PLANNED-21113007
[Patent] タンパク質凍結保存用保護剤2014
- Inventor(s)
  廣明秀一,太田元規,福地佐斗志, 他
- Industrial Property Rights Holder
  廣明秀一,太田元規,福地佐斗志, 他
- Industrial Property Rights Type
  特許
- Filing Date
  2014-02-24
- Data Source
  KAKENHI-PLANNED-21113007
[Patent] ヒトVps4bのMITドメインと二価または三価の金属イオン複合体の構造的特徴およびヒトVps4bのMITドメインによるホスファチジルイノシトールリン酸認識機構2004
- Inventor(s)
  白川昌宏, 廣明秀一, 高須博敏
- Industrial Property Rights Holder
  横浜市立大学
- Industrial Property Number
  2004-350635
- Filing Date
  2004-12-03
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16570136
[Presentation] NMR法を活用したWntシグナル阻害剤の探索2018
- Author(s)
  堀公法、　味岡果澄、　合田名都子、　天野剛志、　廣明秀一
- Organizer
  2017年度生物物理学会中部支部講演会
- Data Source
  KAKENHI-PROJECT-15H04337
[Presentation] タイトジャンクションを制御する植物由来成分の発見2018
- Author(s)
  久田美咲、野田翔太、天野剛志、廣明秀一
- Organizer
  2017年度生物物理学会中部支部講演会
- Data Source
  KAKENHI-PROJECT-15H04337
[Presentation] グリチルリチンと ZO1 タンパク質 PDZ ドメインの直接相互作用の NMR による観測2018
- Author(s)
  久田美咲、野田翔太、天野剛志、廣明秀一
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-15H04337
[Presentation] PDZドメイン結合化合物による上皮細胞の透過性の制御2017
- Author(s)
  天野剛志、野田翔太、中倉由香子、合田名都子、廣明秀一
- Organizer
  第17回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-15H04337
[Presentation] PDZドメイン結合化合物によるタイトジャンクション透過性の制御2017
- Author(s)
  天野剛志、野田翔太、中倉由香子、合田名都子、廣明秀一
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-15H04337
[Presentation] インシリコスクリーニングとNMRを組合わせた新規Dvl阻害剤の探索2017
- Author(s)
  味岡果澄、岡崎寛貴、三上翔平、矢藤まり、近藤優衣、伊藤素行、合田名都子、天野剛志、廣明秀一
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台（国際センター）
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-15H04337
[Presentation] NMRドッキング性能指標を活用したDvl PDZドメイン阻害剤のバーチャルスクリーニング2017
- Author(s)
  味岡果澄、堀公法、岡崎寛貴、三上翔平、伊藤素行、合田名都子、天野剛志、廣明秀一
- Organizer
  第17回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-15H04337
[Presentation] フラボノイドとタイトジャンクション制御タンパク質の直接相互作用2017
- Author(s)
  久田美咲、野田翔太、天野剛志、廣明秀一
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-15H04337
[Presentation] タイトジャンクションのクローディン量を制御する低分子化合物による吸収促進効果2017
- Author(s)
  天野剛志、野田翔太、中倉由香子、合田名都子、廣明秀一
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台（国際センター）
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-15H04337
[Presentation] ヒトタンパク質由来天然変性ペプチドが示す凍結保護作用2017
- Author(s)
  合田名都子、松尾直紀、廣明秀一
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-16K14707
[Presentation] アミロイド線維形成を阻害するアシル化キナ酸類の合成2017
- Author(s)
  石原健広、渡邊紀之、山田智美、尾山公一、重光佳基、天野名都子、廣明秀一、近藤忠雄、吉田久美
- Organizer
  日本農芸化学会2017年度大会
- Place of Presentation
  京都（ウェスティン都ホテル）
- Year and Date
  2017-03-17
- Data Source
  KAKENHI-PROJECT-16K14707
[Presentation] 新規モダリティの医薬品吸収補助剤の基盤技術2017
- Author(s)
  廣明秀一
- Organizer
  BIOTECH2017・アカデミックフォーラム
- Data Source
  KAKENHI-PROJECT-15H04337
[Presentation] アクチン骨格制御分子LIMキナーゼ2のPDZドメインのNMR解析2017
- Author(s)
  堀公法、天野剛志、重光佳基、合田名都子、野田翔太、廣明秀一
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台（国際センター）
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-15H04337
[Presentation] NMR滴定実験とタンパク質間相互作用阻害剤開発から見えてきたこと2017
- Author(s)
  廣明秀一
- Organizer
  第18回若手NMR研究会
- Data Source
  KAKENHI-PROJECT-15H04337
[Presentation] Wntシグナル伝達因子DishevelledのPDZドメインを標的とした阻害剤の探索と分子デザイン2017
- Author(s)
  堀公法、味岡果澄、合田名都子、天野剛志、高岸麻紀、進藤麻子、廣明秀一
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-15H04337
[Presentation] Discovery of potent Dishevelled inhibitors using virtual screening optimized with NMR-based docking performance index.2017
- Author(s)
  堀公法、味岡果澄、合田名都子、天野剛志、高岸麻紀、進藤麻子、廣明秀一
- Organizer
  Wnt研究会2017＠KOBE
- Data Source
  KAKENHI-PROJECT-15H04337
[Presentation] NMR滴定実験と化学シフト摂動実験を再考する2017
- Author(s)
  廣明秀一
- Organizer
  平成29年度日本分光学会NMR部会講習会
- Data Source
  KAKENHI-PROJECT-15H04337
[Presentation] ヒトタンパク質由来天然変性ペプチドを用いた細胞凍結保存2017
- Author(s)
  合田名都子、松尾直紀、廣明秀一
- Organizer
  第17回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-16K14707
[Presentation] PDZドメイン結合化合物によるタイトジャンクションの制御福岡2016/6/7-92016
- Author(s)
  天野剛志,　野田翔太, 中倉由佳子, 合田名都子, 廣明秀一
- Organizer
  第16回日本蛋白質科学会年会
- Place of Presentation
  福岡（国際会議場）
- Year and Date
  2016-06-07
- Data Source
  KAKENHI-PROJECT-15H04337
[Presentation] PDZドメイン阻害剤を利用したタイトジャンクションの制御横浜2016/11/30-12/22016
- Author(s)
  天野剛志、野田翔太、味岡果澄、中倉由香子、合田名都子、廣明秀一
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  横浜（パシフィコ横浜）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-15H04337
[Presentation] PDZドメイン阻害薬によるタイトジャンクション開閉の両方向制御2016
- Author(s)
  天野剛志、三上翔平、野田翔太、中倉由香子、矢藤まり、合田名都子、伊藤素行、廣明秀一
- Organizer
  日本ケミカルバイオロジー学会第11回年会
- Place of Presentation
  京都（京都テルサ）
- Year and Date
  2016-06-15
- Data Source
  KAKENHI-PROJECT-15H04337
[Presentation] タイトジャンクションを制御する低分子化合物の探索と応用2016
- Author(s)
  廣明秀一
- Organizer
  第２回メディカルメッセ（【同時開催】中部地区医療・バイオ系シーズ発表会）
- Place of Presentation
  名古屋市・吹上ホール
- Year and Date
  2016-02-03
- Data Source
  KAKENHI-PROJECT-15H04337
[Presentation] Discovery and pharmacological characterization of tight-junction modulating PDZ domain inhibitors2016
- Author(s)
  廣明秀一
- Organizer
  The 5th International Symposium on Drug Discovery and Design by NMR
- Place of Presentation
  横浜（理化学研究所横浜研究所）
- Year and Date
  2016-08-29
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04337
[Presentation] 低分子化合物によるタイトジャンクションの制御2016
- Author(s)
  天野剛志, 野田翔太, 中倉由香子, 合田名都子,廣明秀一
- Organizer
  第136回日本薬学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-15H04337
[Presentation] 高分子クラウダーとしての天然変性タンパク質とその応用2016
- Author(s)
  松尾直樹、岡崎寛貴、天野剛志、合田名都子、清水佳奈、福地佐斗志、太田元規、廣明秀一
- Organizer
  第16回日本蛋白質科学会年会
- Place of Presentation
  福岡（コンベンションセンター）
- Year and Date
  2016-06-07
- Data Source
  KAKENHI-PROJECT-16K14707
[Presentation] Dimer formation of amyloid beta peptides in 1,1,1,3,3,3-hexafluoro-2-propanol2016
- Author(s)
  重光佳基・岩谷奈央子・合田名都子・松崎瑞季・天野剛志・成田哲博・星美奈子・廣明秀一
- Organizer
  The 27th International Conference on Magnetic Resonance in Biological Systems
- Place of Presentation
  京都（国際会館）
- Year and Date
  2016-08-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K14707
[Presentation] Screening of small compounds for the modulation of tight junction2016
- Author(s)
  天野剛志、中倉由香子、野田翔太、合田名都子、廣明秀一
- Organizer
  The 27th International Conference on Magnetic Resonance in Biological Systems
- Place of Presentation
  京都（京都国際会館）
- Year and Date
  2016-08-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04337
[Presentation] 医療応用を志向したタンパク質・細胞の凍結保護剤2016
- Author(s)
  廣明秀一
- Organizer
  第２回メディカルメッセ（中部地区医療・バイオ系シーズ発表会）
- Place of Presentation
  愛知県名古屋市
- Year and Date
  2016-02-03
- Data Source
  KAKENHI-PROJECT-26650048
[Presentation] 細胞間密着結合の制御に関わるZO-1, LNX-1のPDZドメインとクローディンとの相互作用解析2016
- Author(s)
  合田（天野）名都子、中倉由香子、秋吉由佳里、天野剛志、廣明秀一
- Organizer
  第16回日本蛋白質科学会年会
- Place of Presentation
  福岡（国際会議場）
- Year and Date
  2016-06-07
- Data Source
  KAKENHI-PROJECT-15H04337
[Presentation] 低分子化合物を用いたタイトジャンクションの制御による薬物送達制御2016
- Author(s)
  廣明秀一
- Organizer
  BIOTECH　2016　（アカデミックフォーラム）
- Place of Presentation
  東京ビッグサイト
- Year and Date
  2016-05-11
- Data Source
  KAKENHI-PROJECT-15H04337
[Presentation] 化学シフト温度依存性に着目した天然変性タンパク質領域の同定法2016
- Author(s)
  岡崎寛貴、松尾直紀、天野剛志、廣明秀一
- Organizer
  201５年度生物物物理学会中部地区講演会
- Place of Presentation
  愛知県岡崎市
- Year and Date
  2016-02-29
- Data Source
  KAKENHI-PROJECT-26650048
[Presentation] 1HN Amide Temperature Coefficients: Yet Another NMR Method To Assess Intrinsically Disordered Protein Regiions2016
- Author(s)
  岡崎寛貴、松尾直紀、天野剛志、合田名都子、福地佐斗志、太田元則、廣明秀一
- Organizer
  The 27th International Conference on Magnetic Resonance in Biological Systems
- Place of Presentation
  京都（国際会館）
- Year and Date
  2016-08-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K14707
[Presentation] HFIP中におけるβアミロイド(1-42)ペプチドの二量体形成2016
- Author(s)
  重光佳基、岩谷奈央子、天野剛志、合田名都子、松崎瑞季、成田哲博、星美奈子、廣明秀一
- Organizer
  201５年度生物物物理学会中部地区講演会
- Place of Presentation
  愛知県岡崎市
- Year and Date
  2016-02-29
- Data Source
  KAKENHI-PROJECT-26650048
[Presentation] タイトジャンクションの形成制御に関わるZO-1、LNX-1 PDZドメインのクローディンとの相互作用解析2015
- Author(s)
  天野-合田名都子、中倉由香子、秋吉由佳里、天野剛志、廣明秀一
- Organizer
  BMB2015・第38回日本分子生物学会・第88回日本生化学会合同大会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15H04337
[Presentation] PDZドメインをターゲットとしたタイトジャンクション制御化合物の探索2015
- Author(s)
  野田翔太、天野剛志、中倉由香子、合田名都子、廣明秀一
- Organizer
  第15回日本蛋白質科学会年会
- Place of Presentation
  徳島あわぎんホール
- Year and Date
  2015-06-24
- Data Source
  KAKENHI-PROJECT-15H04337
[Presentation] Cryoprotective Activity in Human Genome-derived Intrinsically Disordered Proteins and Their Pharmaceutical Applications2015
- Author(s)
  H. Hiroaki*
- Organizer
  2015 The 5th NU-TECH ROUND TABLE
- Place of Presentation
  Raleigh, NC, USA
- Year and Date
  2015-11-04
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26650048
[Presentation] ARHGEF11を介したZO-1 ZU5ドメインによるRhoAシグナル調節機構の解析2015
- Author(s)
  石原将、天野剛志、谷口諒、廣明秀一
- Organizer
  BMB2015・第38回日本分子生物学会・第88回日本生化学会合同大会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15H04337
[Presentation] "LNX-PDZ domain結合化合物NPL3007はタイト結合機能や細胞移動に影響を与える"2015
- Author(s)
  三上翔平、矢藤まり、野田翔太、廣明秀一、伊藤素行
- Organizer
  BMB2015・第38回日本分子生物学会・第88回日本生化学会合同大会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15H04337
[Presentation] "Use of principal component analysis of 1H-15N NMR spectra of amyloid- (1–42) peptide for characterization of fibril formation inhibitors. "2015
- Author(s)
  H. Hiroaki*, N. Iwaya, M. Matsuzaki, Y. Shigemitsu, N. Goda, Y. Abe, M. Hoshi, A. Narita
- Organizer
  PACIFICHEM 2015
- Place of Presentation
  Honolulu, Hawaii, USA
- Year and Date
  2015-12-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26650048
[Presentation] 天然変性タンパク質に見出されたタンパク質に対する凍結保護活性の研究2015
- Author(s)
  松尾直紀、合田名都子、清水佳奈、福地佐斗志、太田元規、廣明秀一
- Organizer
  2014年度⽣物物物理学会中部⽀部講演会
- Place of Presentation
  岡崎カンファレンスホール（岡崎市）
- Year and Date
  2015-03-10
- Data Source
  KAKENHI-PROJECT-26650048
[Presentation] NMRデータベースBioMagResBankの統合的拡張と公開2015
- Author(s)
  小林直宏、横地政史、岩田武史、本野千恵、廣明秀一、児嶋長次郎、藤原敏道
- Organizer
  第54回NMR討論会
- Place of Presentation
  千葉工業大学, 千葉県習志野市
- Year and Date
  2015-11-06
- Data Source
  KAKENHI-PROJECT-15K06970
[Presentation] ARHGEF11を介したZO-1 ZU5ドメインによるRhoAシグナル調節機構の解析2015
- Author(s)
  石原将、天野剛志、谷口諒、廣明秀一
- Organizer
  第61回日本薬学会東海支部大会
- Place of Presentation
  名古屋市立大学田辺通キャンパス
- Data Source
  KAKENHI-PROJECT-15H04337
[Presentation] 低分子化合物を使ったタイトジャンクションの調節2015
- Author(s)
  天野剛志、野田翔太、中倉由香子、合田名都子、廣明秀一
- Organizer
  BMB2015・第38回日本分子生物学会・第88回日本生化学会合同大会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15H04337
[Presentation] 医療応用を志向したタンパク質の凍結・凍結乾燥保護剤2014
- Author(s)
  廣明秀一
- Organizer
  新技術説明会-中部地区医療・バイオ系シーズ発表会2014
- Place of Presentation
  ウィンクあいち（名古屋市）
- Year and Date
  2014-12-10
- Data Source
  KAKENHI-PROJECT-26650048
[Presentation] タイトジャンクション抑制因子LNX1p80によるJAM4とクローディン分子認識機構2014
- Author(s)
  廣明秀一ら
- Organizer
  日本薬学会第134回年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PLANNED-21113007
[Presentation] I型AAA-ATPaseのN末端ドメインに存在するCa2+結合部位の機能比較2013
- Author(s)
  岩谷奈央子、合田名都子、高須博敏、白川昌宏、田中俊樹、濵田大三、廣明秀一 (廣明)
- Organizer
  日本薬学会第133年会
- Place of Presentation
  パシフィコ横浜(横浜市）
- Data Source
  KAKENHI-PROJECT-22570118
[Presentation] IDEAL: the collection and visualization of knowledge regarding intrinsically disordered proteins verified by experiments2013
- Author(s)
  雨宮崇之、坂本盛宇、野辺由紀子、村上聖子、嘉戸裕美子、細田和男、小池亮太郎、廣明秀一、太田元規、福地佐斗志
- Organizer
  The 2nd Internatiional Symposium on Intrinsically Disordered Proteins
- Place of Presentation
  理化学研究所横浜研究所
- Year and Date
  2013-01-23
- Data Source
  KAKENHI-PROJECT-22570118
[Presentation] I型AAA-ATPaseのN末端ドメインに存在するCa^2+結合部位の機能比較2013
- Author(s)
  岩谷奈央子、合田名都子、高須博敏、白川昌宏、田中俊樹、〓田大三、廣明秀一
- Organizer
  日本薬学会第133年会
- Place of Presentation
  パシフィコ横浜(横浜市)
- Year and Date
  2013-03-28
- Data Source
  KAKENHI-PROJECT-22570118
[Presentation] 天然変性タンパク質データベースIDEAL の機能拡張 ―PPI ネットワーク2013
- Author(s)
  T.Amemiya, H.Hiroaki, M.Ota & S.Fukuchi, et al.
- Organizer
  第51回日本生物物理学会
- Place of Presentation
  京都
- Year and Date
  2013-10-28
- Data Source
  KAKENHI-PLANNED-21113007
[Presentation] A hypothesis of membrane skeleton: Do SPFH-domain proteins form memrbane scaffolding fibers?2013
- Author(s)
  廣明秀一
- Organizer
  Nagoya Symposium Frontiers in Structural Physiology
- Place of Presentation
  名古屋大学豊田講堂
- Year and Date
  2013-01-22
- Data Source
  KAKENHI-PLANNED-21113007
[Presentation] IDEAL: the collection and visualization of knowledge regarding intrinsically disordered proteins verified by experiments2013
- Author(s)
  雨宮崇之、坂本盛宇、野辺由紀子、村上聖子、嘉戸裕美子、細田和男、小池亮太郎、廣明秀一、太田元規、福地佐斗志 (福地)
- Organizer
  The 2nd Internatiional Symposium on Intrinsically Disordered Proteins
- Place of Presentation
  理化学研究所横浜研究所(横浜市）
- Data Source
  KAKENHI-PROJECT-22570118
[Presentation] The IDEAL database, Intrinsically disordered proteins with extensive annotations and literature2012
- Author(s)
  S.Fukuchi, H.Hiroaki, M.Ota, et al.
- Organizer
  The Gordon Research Conference of Intrinsically Disordered Proteins
- Place of Presentation
  Mount Snow Resort (USA)
- Year and Date
  2012-07-10
- Data Source
  KAKENHI-PLANNED-21113007
[Presentation] 天然変性タンパク質データベースIDEALの開発2012
- Author(s)
  雨宮崇之、坂本盛宇、野辺由紀子、村上聖子、細田和男、小池亮太郎、廣明秀一、太田元規、福地佐斗志
- Organizer
  第12回日本蛋白質科学会年会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2012-06-22
- Data Source
  KAKENHI-PROJECT-22570118
[Presentation] 微小管切断酵素p60-kataninに対するCa2+の効果2012
- Author(s)
  岩谷奈央子、合田名都子、天野剛志、藤原芳江、濵田大三、伊倉貞吉、白川昌宏、廣明秀一(岩谷）
- Organizer
  第12回日本蛋白質科学会年会
- Place of Presentation
  名古屋国際会議場（名古屋市）
- Data Source
  KAKENHI-PROJECT-22570118
[Presentation] 創薬標的としてのAAA-ATPaseとNMR構造生物学2012
- Author(s)
  廣明秀一
- Organizer
  第一回岐阜構造生物学・医学・論理的創薬研究会シンポジウム:構造生物学・医学・論理的創薬の拠点構築を目指して
- Place of Presentation
  岐阜大学医学部多目的室(岐阜市)
- Year and Date
  2012-03-23
- Data Source
  KAKENHI-PROJECT-22570118
[Presentation] 天然変性タンパク質データベースIDEALの開発2012
- Author(s)
  雨宮崇之、坂本盛宇、野辺由紀子、村上聖子、細田和男、小池亮太郎、廣明秀一、太田元規、福地佐斗志 (福地)
- Organizer
  第12回日本蛋白質科学会年会
- Place of Presentation
  名古屋国際会議場（名古屋市）
- Data Source
  KAKENHI-PROJECT-22570118
[Presentation] 創薬標的としてのAAA-ATPaseとNMR構造生物学2012
- Author(s)
  廣明秀一
- Organizer
  第一回岐阜構造生物学・医学・論理的創薬研究会
- Place of Presentation
  岐阜大(招待講演)
- Year and Date
  2012-03-23
- Data Source
  KAKENHI-PLANNED-21113007
[Presentation] 創薬標的としてのAAA-ATPaseとNMR構造生物学2012
- Author(s)
  廣明秀一
- Organizer
  第一回岐阜構造生物学・医学・論理的創薬研究会シンポジウム:構造生物学・医学・論理的創薬の拠点構築を目指して
- Place of Presentation
  岐阜大学医学部(岐阜市)
- Year and Date
  2012-03-23
- Data Source
  KAKENHI-PROJECT-22570118
[Presentation] 微小管切断酵素p60-kataninに対するCa^2+の効果2012
- Author(s)
  岩谷奈央子、合田名都子、天野剛志、藤原芳江、〓田大三、伊倉貞吉、白川昌宏、廣明秀一
- Organizer
  第12回日本蛋白質科学会年会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2012-06-22
- Data Source
  KAKENHI-PROJECT-22570118
[Presentation] NMRの原理1D/2D-NMR2011
- Author(s)
  廣明秀一
- Organizer
  2011年日本分光学会NMR講習会
- Place of Presentation
  東京大学(招待講演)
- Year and Date
  2011-07-20
- Data Source
  KAKENHI-PLANNED-21113007
[Presentation] Structure and Function of the Two N-Terminal Domains of AAA-ATPases, p60 Katanin and Nuclear Valosin Containing Protein Like 2 (NVL2)2011
- Author(s)
  廣明秀一
- Organizer
  9th International Conference on AAA proteins
- Place of Presentation
  熊本市国際交流センター(熊本市)
- Year and Date
  2011-11-06
- Data Source
  KAKENHI-PROJECT-22570118
[Presentation] Structure and Function of the Two N-Terminal Domains of AAA-ATPases, p60 Katanin and Nuclear Valosin Containing Protein Like 2 (NVL2)、9th International Conference on AAA proteins2011
- Author(s)
  廣明秀一
- Organizer
  国際AAA会議
- Place of Presentation
  熊本市国際交流センター
- Year and Date
  2011-11-06
- Data Source
  KAKENHI-PLANNED-21113007
[Presentation] Contribution of NMR studies to constructing SAHG, a database of predicted protein structures from human genome2011
- Author(s)
  廣明秀一, ら
- Organizer
  第50回記念NMR討論会国際シンポジウム
- Place of Presentation
  横浜大桟橋ホール
- Year and Date
  2011-11-15
- Data Source
  KAKENHI-PLANNED-21113007
[Presentation] 核小体に局在するAAA ATPase, NVL2のN末端ドメインの解析2011
- Author(s)
  藤原芳江、合田名都子*、岩谷奈央子*、天野剛志*、白川昌宏、廣明秀一
- Organizer
  第34回日本分子生物学学会年会
- Place of Presentation
  パシフィコ横浜(横浜市)
- Year and Date
  2011-12-13
- Data Source
  KAKENHI-PROJECT-22570118
[Presentation] A hypothesis of membrane skeleton : Are SPFH-domain proteins membrane scaffolding proteins?2011
- Author(s)
  廣明秀一
- Organizer
  Kobe University-University of Washington Joint Symposium
- Place of Presentation
  神戸・ポートピアホテル(招待講演)
- Year and Date
  2011-12-13
- Data Source
  KAKENHI-PLANNED-21113007
[Presentation] 核小体に局在するAAAATPase,NVL2のN末端ドメインの解析2011
- Author(s)
  藤原芳江、合田名都子、岩谷奈央子、天野剛志、白川昌宏、廣明秀
- Organizer
  第34回日本分子生物学学会年会
- Place of Presentation
  パシフィコ横浜(横浜市)
- Year and Date
  2011-12-13
- Data Source
  KAKENHI-PROJECT-22570118
[Presentation] タンパク質^1H-^<15>N二次元NMRの徹底理解2011
- Author(s)
  廣明秀一
- Organizer
  第12回若手NMR研究会
- Place of Presentation
  琵琶湖リゾートクラブ(招待講演)
- Year and Date
  2011-06-23
- Data Source
  KAKENHI-PLANNED-21113007
[Presentation] NMRを利用した創薬支援研究の現状と未来--"偶発的"なタンパク質・薬剤相互作用の構造生物学2011
- Author(s)
  廣明秀一
- Organizer
  2011 名大サマーセミナー
- Place of Presentation
  名古屋大学(招待講演)
- Year and Date
  2011-09-03
- Data Source
  KAKENHI-PLANNED-21113007
[Presentation] Contribution of NMR studies to constructing SAHG, a database of predicted protein structures from human genome2011
- Author(s)
  廣明秀一、合田(天野)名都子*、天野剛志、本野千恵子、富井健太郎、清水佳奈、木下賢吾、太田元規
- Organizer
  ISNMR2011-第50回記念NMR討論会国際シンポジウム
- Place of Presentation
  横浜大桟橋ホール(横浜市)
- Year and Date
  2011-11-15
- Data Source
  KAKENHI-PROJECT-22570118
[Presentation] MR Analysis of the Toxic Ab□High Molecular Weight Oligomer2011
- Author(s)
  廣明秀一
- Organizer
  先端医療センターアルツハイマー病ミニワークショップ
- Place of Presentation
  神戸臨床情報センター(招待講演)
- Year and Date
  2011-09-22
- Data Source
  KAKENHI-PLANNED-21113007
[Presentation] 核小体に局在するAAA ATPase, NVL2のN末端ドメインの解析2011
- Author(s)
  藤原芳江、合田名都子、岩谷奈央子, 天野剛志、白川昌宏、廣明秀一
- Organizer
  日本分子生物学会
- Place of Presentation
  パシフィコ横浜(神奈川県)
- Year and Date
  2011-12-14
- Data Source
  KAKENHI-PROJECT-23590042
[Presentation] SOFAST-HMQC/BEST-HNCAの理解と蛋白質NMRのケミカルバイオロジーへの応用2010
- Author(s)
  廣明秀一
- Organizer
  平成22年度分光学会NMR分光部会シンポジウム
- Place of Presentation
  東大
- Year and Date
  2010-09-09
- Data Source
  KAKENHI-PLANNED-21113007
[Presentation] RESAT-vector を用いた天然変性タンハク質配列の網羅的検証系の確立2010
- Author(s)
  合田(天野)名都子,太田元規,廣明秀一, 他
- Organizer
  第10回蛋白質科学会
- Place of Presentation
  札幌
- Year and Date
  2010-06-16
- Data Source
  KAKENHI-PLANNED-21113007
[Presentation] NVL2のN末端にある新規ヌクレオリン結合ドメインの構造と機能2010
- Author(s)
  藤原芳江, 藤原健一郎, 合田名都子, 岩谷奈央子, 天野剛志, 廣明秀一
- Organizer
  第49回NMR討論会
- Year and Date
  2010-11-16
- Data Source
  KAKENHI-PROJECT-22570118
[Presentation] A method for high-throughput construction of bacterial protein expression vector and its application for cell biology.2008
- Author(s)
  廣明秀一
- Organizer
  米国蛋白質科学会第22回年会
- Place of Presentation
  サンディエゴ(アメリカ)
- Year and Date
  2008-07-22
- Data Source
  KAKENHI-PROJECT-19657048
[Presentation] エンドソーム膜出芽と微小管切断に関わる分子に共通するドメイン構成2007
- Author(s)
  廣明秀一
- Organizer
  第30回分子生物学会・生化学会合同年会(BMB2007)
- Place of Presentation
  パシフィコ横浜、横浜
- Data Source
  KAKENHI-PROJECT-19657048
[Presentation] 新規蛍光標識タグLBTの利用と細胞膜透過ペプチドの探索2007
- Author(s)
  廣明秀一
- Organizer
  第3回神戸大学医学シーズフォーラム
- Place of Presentation
  神戸大学神緑会館、神戸
- Year and Date
  2007-11-15
- Data Source
  KAKENHI-PROJECT-19657048
[Presentation] 新規ペプチドタグを用いた細胞へのタンパク質導入と検出法2007
- Author(s)
  合田(天野)名郁子、天野剛志、猪股晃介、白川昌宏、田中俊樹、廣明秀一
- Organizer
  第30回分子生物学会・生化学会合同年会(BMB2007)
- Place of Presentation
  パシフィコ横浜、横浜
- Data Source
  KAKENHI-PROJECT-19657048
[Presentation] 天然変性タンパク質がもつ凍結保護作用の発見
- Author(s)
  松尾直紀、合田名都子、清水佳奈、福地佐斗志、太田元規、廣明秀一
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（横浜市）
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-26650048
[Presentation] 天然変性タンパク質に広く認められた凍結保護作用の評価
- Author(s)
  松尾直紀、合田名都子、清水佳奈、福地佐斗志、太田元規、廣明秀一
- Organizer
  第14回日本蛋白質科学会年会
- Place of Presentation
  ワークピア横浜（横浜市）
- Year and Date
  2014-06-25 – 2014-06-27
- Data Source
  KAKENHI-PROJECT-26650048
[Presentation] ヒトゲノム配列に含まれる天然変性タンパク質の医療応用
- Author(s)
  松尾直紀、合田名都子、清水佳奈、福地佐斗志、太田元規、廣明秀一
- Organizer
  第135回日本薬学会年会
- Place of Presentation
  神戸学院大学（神戸市）
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-26650048

1. TENNO Takeshi (70381663)

# of Collaborated Projects: 2 results

# of Collaborated Products: 35 results
2. FUJIWARA Yoshie (90423095)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
3. Hoshi Minako (30374010)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
4. TENNO Natsuko

# of Collaborated Projects: 2 results

# of Collaborated Products: 28 results
5. SHIRAKAWA Masahiro (00202119)

# of Collaborated Projects: 1 results

# of Collaborated Products: 27 results
6. OTA Motonori (40290895)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
7. FUKUCHI Satoshi (70360336)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
8. FURUSE Mikio (90281089)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. IKURA Teikichi (50251393)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. HAMADA Daizo (60372132)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. Kobayashi Naohiro (80272160)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. MOTONO Chie (80415752)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
13. 朽尾豪人 (70336593)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 大西隆之 (30418959)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 垣尾翔大 (10789085)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 笹原智也 (30735345)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 久保厚子 (70647792)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 児嶋長次郎 (50333563)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
19. NODA Shota

# of Collaborated Projects: 1 results

# of Collaborated Products: 15 results
20. HORI Kiminori

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
21. KODERA Noriyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 杤尾豪人

# of Collaborated Projects: 0 results

# of Collaborated Products: 22 results
23. 高井義美

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 安藤敏夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HIROAKI HIDEKAZU 廣明 秀一

HIROAKI Hidekazu 廣明 秀一

Research Projects

Research Products

Co-Researchers

PDZ足場タンパク質の機能に介入する阻害剤ライブラリの構築と創薬応用Principal Investigator

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Review Section

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Propagation of Alzheimer's disease neuronal cell death by intracellular formation and secretion of abnormal aggregates

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Application of molecular shielding effect of intrinsically disordered proteins towards development of protein stabilizersPrincipal Investigator

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Dynamic mechanisms of regurating cell-cell junction and cell shape of epithelial cells unravelled by protein structure informationPrincipal Investigator

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Development of NMR drug discovery pipeline using database

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Elucidation of a neurodegenerative mechanism induced by a new Alzheimer's disease drug target and its inhibition

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Medicinal application of intrinsically disordered proteins of unknown functionPrincipal Investigator

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ヌクレオリンによる核酸医薬のガン細胞特異的シャトル機構の解明

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Synthetic and Structural Biology Approach for Understanding Mechanism of AAA-ATPasePrincipal Investigator

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Development and application of a database of intrinsic protein disorder

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Review Section

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ランタニド結合配列を用いたエンドソーム・マクロピノソームの可視化Principal Investigator

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Molecular basis of the adaptor domains from AAA-ATPases for locating organelles.Principal Investigator

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Structural study of signal transduction by membrane receptors through protein-protein interactions

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HIROAKI HIDEKAZU 廣明秀一

HIROAKI Hidekazu 廣明秀一

[Book] In silico創薬におけるスクリーニングの高速化・効率化技術　第一章　第７節NMRによるin-silicoスクリーニング計算結果の検証2018

[Book] Protein-Ligand Interactions Studied by NMR　（Experimental Approaches of NMR Spectroscopy ‐ Methodology and Application to Life Science and Materials Science）2017