Funamoto Satoru 舟本聡

… Alternative Names

舟本聡フナモトサトル

FUNAMOTO Satoru 舟本聡

Less

Researcher Number	10345043
Other IDs
Affiliation (Current)	2025: 同志社大学, 生命医科学部, 教授
Affiliation (based on the past Project Information) *help	2023: 同志社大学, 生命医科学部, 教授 2022: 同志社大学, 生命医科学部, 准教授 2016 – 2018: 同志社大学, 生命医科学部, 准教授 2009: 生命医科学部, 准教授 2008 – 2009: Doshisha University, 生命医科学部, 准教授 … More 2007: Doshisha University, 生命医科学部・設置準備室, 准教授 2006: 東京大学, 大学院医学系研究科, 助手 2002 – 2005: 東京大学, 大学院・医学系研究科, 助手 2004: University of Tokyo, Graduate School of Medicine, Instructor, 大学院医学系研究科, 助手 Less
Review Section/Research Field	Principal Investigator Nerve anatomy/Neuropathology / Basic Section 46020:Anatomy and histopathology of nervous system-related / Nerve anatomy/Neuropathology Except Principal Investigator Biological Sciences
Keywords	Principal Investigator アルツハイマー病 / アミロイドβ / 脳神経疾患 / プレセニリン / ガンマセクレターゼ / アルツハイマー / 神経変性疾患 / クリアランス / 大脳皮質 / 小脳 … More / リンパ節 / 糖鎖 / γセクレターゼ / 基質選択性 / 糖鎖修飾 / セクレターゼ / アミロイド / ガンマセクレター / Ass / PIP2 / Aβ / ホスフォイノシチド / アミロイドβタンパク質 / アミロイドベータ / APP / イプシロン切断 / ガンマ切断 / アミロイドベータタンパク質 … More Except Principal Investigator アルツハイマー病 / Neuronal death / Neurofibrillary tangles / Tau / Alzheimer's disease / 神経細胞死 / 神経原線維変化 / タウ蛋白 / アミロイドβタンパク質 / 酵素 / タンパク質 / 認知症 / 脳・神経 / 脳神経疾患 / αヘリックス / 1型膜タンパク質 / APP / 膜内分解 / Aβ産生 / アミロイドβタンパク / トリペプチド仮説 / ε切断 / γ切断 / γセクレターゼ / Alzheimer disease Less

Understanding of A potential defense mechanism against amyloid deposition in cerebellumPrincipal Investigator
- Principal Investigator
  
  舟本聡
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 46020:Anatomy and histopathology of nervous system-related
- Research Institution
  Doshisha University
Identification of glycosylation site involving into substrate preference of gamma-secretasePrincipal Investigator
- Principal Investigator
  
  Funamoto Satoru
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Doshisha University
Regulation of gamma-secretase activityPrincipal Investigator
- Principal Investigator
  
  FUNAMOTO Satoru
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Doshisha University
Characterization of the enzymatic properties of γ-secretase
- Principal Investigator
  
  IHARA Yasuo
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Doshisha University
  The University of Tokyo
アミロイド前駆体タンパク質のガンマ切断部位を制御する因子の探索Principal Investigator
- Principal Investigator
  
  舟本聡
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  The University of Tokyo
ガンマセクレターゼの同定とアミロイドベータタンパク質Aβ42の産生機序Principal Investigator
- Principal Investigator
  
  舟本聡
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  The University of Tokyo
Hyperphosphorylation and aggregation of tau protein, and neuronal death
- Principal Investigator
  
  IHARA Yasuo
- Project Period (FY)
  2000 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  University of Tokyo

All 2023 2019 2018 2017 2009 2008 2007 2006 2004 Other

All Journal Article Presentation Book

[Book] Cell Motility : From Molecules to Organisms2004
- Author(s)
  Satoru Funamoto
- Total Pages
  342
- Publisher
  John Wiley & Sons, Ltd
- Data Source
  KAKENHI-PROJECT-15700271
[Journal Article] 抗アミロイド療法としてのAPP特異的切断抑制に関する研究2023
- Author(s)
  舟本　聡
- Journal Title
  
  Dementia Japan
  
  Volume: 37 Pages: 421-428
- Data Source
  KAKENHI-PROJECT-22K06466
[Journal Article] The senile plaque: Morphological differences in APP knock‐in mice brains by fixatives2023
- Author(s)
  Yoshimura Rikuya、Miyasaka Tomohiro、Funamoto Satoru、Saito Takashi、Saido Takaomi C.、Ikegawa Masaya、Kakuda Nobuto
- Journal Title
  
  Brain and Behavior
  
  Volume: 13 Issue: 4 Pages: 1-4
- DOI
  10.1002/brb3.2953
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06466, KAKENHI-PROJECT-23K24207
[Journal Article] Pleckstrin homology domain of p210 BCR-ABL interacts with cardiolipin to regulate its mitochondrial translocation and subsequent mitophagy2018
- Author(s)
  Shimasaki K, Watanabe-Takahashi M, Umeda M, Funamoto S, Saito Y, Noguchi N, Kumagai K, Hanada K, Tsukahara F, Maru Y, Shibata N, Naito M, Nishikawa K.
- Journal Title
  
  Genes to Cells
  
  Volume: 23 Issue: 1 Pages: 22-34
- DOI
  10.1111/gtc.12544
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K07044, KAKENHI-PLANNED-15H05930, KAKENHI-PROJECT-17H03805, KAKENHI-PROJECT-15K08480, KAKENHI-ORGANIZER-17H06413, KAKENHI-PROJECT-17H03821
[Journal Article] Glycosylation status of nicastrin influences catalytic activity and substrate preference of γ-secretase.2018
- Author(s)
  Moniruzzaman M, Ishihara S, Nobuhara M, Higashide H, Funamoto S.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 502 Issue: 1 Pages: 98-103
- DOI
  10.1016/j.bbrc.2018.05.126
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07044
[Journal Article] Alanine substitutions in the GXXXG motif alter C99 cleavage by γ-secretase but not its dimerization2017
- Author(s)
  Hidekazu Higashide, Seiko Ishihara, Mika Nobuhara, Yasuo Ihara, Satoru Funamoto
- Journal Title
  
  Journal of Neurochemistry
  
  Volume: 140 Issue: 6 Pages: 955-962
- DOI
  10.1111/jnc.13942
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16K07044
[Journal Article] γ-Secretase: Successive tri- and tetrapeptide release from the transmembrane domain of sCTF.2009
- Author(s)
  Takami M, Nagashima Y, Sano Y, Ishihara S, Morishima-Kawashima M, Funamoto S, Ihara Y
- Journal Title
  
  J Neurosci 29
  
  Pages: 13042-52
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17025008
[Journal Article] γ-Secretase: Successive tripeptide and tetrapeptide release from the transmembrane domain of (R)-carboxyl terminal fragment.2009
- Author(s)
  Mako Takami, Yu Nagashima, Yoshihisa Sano, Seiko Ishihara, Maho Morishima-Kawashima, Satoru Funamoto, Yasuo Ihara
- Journal Title
  
  J. Neurosci. 29
  
  Pages: 13042-13052
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19680019
[Journal Article] Enzymatic characteristics of I213T mutant presenilin-1/gamma-secretase in cell models and knock-in mouse brains: familial Alzheimer disease-linked mutation impairs gamma-site cleavage of amyloid precursor protein C-terminal fragment beta.2008
- Author(s)
  Shimojo M, Sahara N, Mizoroki T, Funamoto S, Morishima-Kawashima M, Kudo T, Takeda M, Ihara Y, Ichinose H, Takashima A
- Journal Title
  
  J Biol Chem 283
  
  Pages: 16488-96
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17025008
[Journal Article] Phosphoinositides suppressγ-secretase in both the detergent-soluble and insoluble states.2008
- Author(s)
  Satoko Osawa, Satoru Funamoto (corresponding author), Mika Nobuhara, Satoko Wada-Kakuda, Masafumi Shimojo, Sosuke Yagishita, Yasuo Ihara
- Journal Title
  
  J. Biol. Chem. 283
  
  Pages: 19283-19292
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19680019
[Journal Article] Enzymatic Characteristics of I213T Mutant Presenilin-1/γ-Secretase in Cell Models and Knock-in Mouse Brains FAMILIAL ALZHEIMER DISEASE-LINKED MUTATION IMPAIRSγ-SITE CLEAVAGE OF AMYLOID PRECURSOR PROTEIN C-TERMINAL FRAGMENTβ.2008
- Author(s)
  Masafumi Shimojo, Naruhiko Sahara, Tatsuya Mizoroki, Satoru Funamoto, Maho Morishima -Kawashima, Takashi Kudo, Masatoshi Takeda, Yasuo Ihara, Hiroshi Ichinose, Akihiko Takashima.
- Journal Title
  
  J. Biol Chem. 283
  
  Pages: 16488-16496
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19680019
[Journal Article] Phosphoinositides suppress gamma-secretase in both the detergent-soluble and -insoluble states.2008
- Author(s)
  Osawa S, Funamoto S, Nobuhara M, Wada-Kakuda S, Shimojo M, Yagishita S, Ihara Y
- Journal Title
  
  J Biol Chem 283
  
  Pages: 19283-92
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17025008
[Journal Article] Equimolar production of Aβ and AICD by γ-secretase2007
- Author(s)
  Satoru Funamoto et al.
- Journal Title
  
  Proceedings of the 10th International Conference on Alzheimer's Disease and Related Disorders (印刷中)
- Data Source
  KAKENHI-PROJECT-17700330
[Journal Article] Active gamma-secretase complexes contain only one of each component.2007
- Author(s)
  Toru Sato, Thekla S. Diehl, Saravanakumar Narayanan, Satoru Funamoto, Yasuo Ihara, Bart De Strooper, Harald Steiner, Christian Haass, Michael S. Wolfe.
- Journal Title
  
  J. Biol Chem. 282
  
  Pages: 33985-33993
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19680019
[Journal Article] Active gamma -secretase complexes contain only one of each component2007
- Author(s)
  Sato T, Diehl TS, Narayanan S, Funamoto S, Ihara Y, De Strooper B, Steiner H, Haass C, Wolfe MS
- Journal Title
  
  J Biol Chem 282
  
  Pages: 33985-33993
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17025008
[Journal Article] Equimolar production of amyloid β-protein and APP intracellular domain from-carboxyl terminal fragment by γ-secretase.2006
- Author(s)
  Kakuda N, Funamoto S, Yagishita S, Takami M, Osawa S, Dohmae N, Ihara Y
- Journal Title
  
  Journal of Biological Chemistry 281
  
  Pages: 14776-14786
- Data Source
  KAKENHI-PROJECT-17025008
[Journal Article] Equimolar production of amyloid s-protein and APP intracellular domain from s-carboxyl terminal fragment by γ-secretase.2006
- Author(s)
  Kakuda N, Funamoto S, Yagishita S, Takami M, Osawa S, Dohmae N, Ihara Y
- Journal Title
  
  J Biol Chem 281
  
  Pages: 14776-14786
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17025008
[Journal Article] Truncated carboxyl terminal fragments of β-amyloid precursor protein are processed to amyloid Β-proteins 40 and 42.2004
- Author(s)
  Funamoto S, Morishima-Kawashima M, Tanimura Y, Hirotani N, Saido TC, Ihara Y
- Journal Title
  
  Biochemistry 43
  
  Pages: 13532-13540
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12210005
[Journal Article] Truncated carboxyl terminal fragments of β-amyloid precursor protein are processed to amyloid β-proteins 40 and 42.2004
- Author(s)
  Funamoto S, et al.
- Journal Title
  
  Biochemistry 43
  
  Pages: 13532-13540
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12210005
[Journal Article] Truncated carboxyl terminal fragments of β-amyloid precursor protein are processed to amyloid β-proteins 40 and 42.2004
- Author(s)
  Funamoto S, et al.
- Journal Title
  
  Biochemistry 43・42
  
  Pages: 13532-13540
- Data Source
  KAKENHI-PROJECT-12210005
[Journal Article] Truncated carboxyl terminal fragments of β-amyloid precursor protein are processed to amyloid β-proteins 40 and 422004
- Author(s)
  Satoru Funamoto
- Journal Title
  
  Biochemistry 43・42
  
  Pages: 13532-13540
- Data Source
  KAKENHI-PROJECT-15700271
[Presentation] Effect of Nicastrin Glycosylation on Enzymatic Activity and Substrate Preference of gamma-Secretase2023
- Author(s)
  FUNAMOTO Satoru
- Organizer
  ADPD2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06466
[Presentation] 抗アミロイド療法としてのAPP特異的切断抑制2023
- Author(s)
  舟本　聡
- Organizer
  第42回日本認知症学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-22K06466
[Presentation] GYCOSYTATION STATUS OF NICASTRIN INCLUENCES ENZYMATIC ACTIVITY AND SUBSTRATE PREFERENCE OF GAMMA-SECRETASE2019
- Author(s)
  Satoru Funamoto
- Organizer
  ADPD2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07044
[Presentation] Glycosylation deficiency of nicastrin induces cleavage defect of g-secretase2018
- Author(s)
  モニルッザマン　モハマド、石原聖子、延原美香、舟本　聡
- Organizer
  日本認知症学会
- Data Source
  KAKENHI-PROJECT-16K07044
[Presentation] Modulation of Amyloid beta by Tetraspanin 72017
- Author(s)
  Mohammad Moniruzzaman, Mika Nobuhara, Seiko Ishihara, Satoru Funamoto
- Organizer
  ConBio2017（日本分子生物学会）
- Data Source
  KAKENHI-PROJECT-16K07044
[Presentation] Alanine substitutions in the GXXXG motif alter C99 cleavage by gamma-secretase but not its dimerization2017
- Author(s)
  Hidekazu Higashide, Yasuo Ihara, Satoru Funamoto
- Organizer
  The 13th international Conference on Alzheimer's disease and Parkinson's disease
- Place of Presentation
  ウィーン、オーストリア
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07044
[Presentation] アミロイドβタンパク質産生機序 -トリペプチド仮説の検証-2009
- Author(s)
  舟本聡
- Organizer
  第82回日本生化学会大会シンポジウム
- Place of Presentation
  神戸ポートアイランド(兵庫県)
- Year and Date
  2009-10-23
- Data Source
  KAKENHI-PROJECT-19680019
[Presentation] アミロイドβタンパク質産生機序-トリペプチド仮説の検証-2009
- Author(s)
  舟本聡
- Organizer
  第82回日本生化学会大会シンポジウム
- Place of Presentation
  神戸市、兵庫県、日本
- Year and Date
  2009-10-23
- Data Source
  KAKENHI-PROJECT-19680019
[Presentation] APP cleavage by g-secretase: To test the tripeptide hypothesis using LC-MS/MS2008
- Author(s)
  Takami M, Sano Y, Funamoto S, Tsuji S, Morishima M, Ihara Y
- Organizer
  ICAD
- Place of Presentation
  Chicago
- Data Source
  KAKENHI-PROJECT-17025008
[Presentation] γセクレターゼ活性におけるホスフォイノシチドの影響2007
- Author(s)
  舟本聡
- Organizer
  第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
- Place of Presentation
  横浜市、神奈川、日本
- Data Source
  KAKENHI-PROJECT-19680019
[Presentation] Effects of phosphoinositides onγ-secretase activity in detergent soluble/insoluble states2007
- Author(s)
  舟本聡
- Organizer
  Society for Neuroscience meeting 2007
- Place of Presentation
  San Diego, CA USA
- Data Source
  KAKENHI-PROJECT-19680019
[Presentation] Effects of phosphoinositides onγ-secretase activity in detergent soluble/insoluble states2007
- Author(s)
  舟本聡
- Organizer
  第26回日本認知症学会学術集会
- Place of Presentation
  大阪市、大阪、日本
- Data Source
  KAKENHI-PROJECT-19680019
[Presentation] Genetic association of dynamin-binding protein gene with late-onset Alzheimer's disease
- Author(s)
  Kuwano R, Miyashita A, Arai H, Asada T, Imagawa M, Shoji M, Higuchi S, Urakami K, Kakita A, Takahashi H, Tsukie T, Funamoto S, Toyabe S, Akazawa K, Kanazawa I, Ihara Y
- Place of Presentation
  Hiroshima
- Data Source
  KAKENHI-PROJECT-17025008

1. IHARA Yasuo (60114386)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
2. MORISHIMA Maho (50204722)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
3. MIYASAKA Tomohiro (90342857)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. ITO Mamoru (00176364)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. FUJITA Shinobu (30092323)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 元永耕三 (20345044)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 山崎恒夫 (80200658)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 小山文隆 (40194641)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 岡澤均 (50261996)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. Moniruzzaman Mohammad

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results

Funamoto Satoru 舟本 聡

舟本 聡 フナモト サトル

FUNAMOTO Satoru 舟本 聡

Research Projects

Research Products

Co-Researchers

Understanding of A potential defense mechanism against amyloid deposition in cerebellumPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of glycosylation site involving into substrate preference of gamma-secretasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regulation of gamma-secretase activityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Characterization of the enzymatic properties of γ-secretase

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

アミロイド前駆体タンパク質のガンマ切断部位を制御する因子の探索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ガンマセクレターゼの同定とアミロイドベータタンパク質Aβ42の産生機序Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Hyperphosphorylation and aggregation of tau protein, and neuronal death

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Book] Cell Motility : From Molecules to Organisms2004

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] 抗アミロイド療法としてのAPP特異的切断抑制に関する研究2023

Author(s)

Journal Title

Data Source

[Journal Article] The senile plaque: Morphological differences in APP knock‐in mice brains by fixatives2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Pleckstrin homology domain of p210 BCR-ABL interacts with cardiolipin to regulate its mitochondrial translocation and subsequent mitophagy2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Glycosylation status of nicastrin influences catalytic activity and substrate preference of γ-secretase.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Alanine substitutions in the GXXXG motif alter C99 cleavage by γ-secretase but not its dimerization2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] γ-Secretase: Successive tri- and tetrapeptide release from the transmembrane domain of sCTF.2009

Author(s)

Journal Title

Funamoto Satoru 舟本聡

舟本聡フナモトサトル

FUNAMOTO Satoru 舟本聡