Iesaki Takafumi 家崎貴文

… Alternative Names

IESAKI Takafumi 家崎貴文

家崎貴文イエサキタカフミ

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Researcher Number	10348956
Other IDs
Affiliation (Current)	2025: 順天堂大学, 保健医療学部, 先任准教授
Affiliation (based on the past Project Information) *help	2019 – 2023: 順天堂大学, 保健医療学部, 先任准教授 2016 – 2018: 順天堂大学, 医学部, 先任准教授 2012 – 2015: 順天堂大学, 医学部, 准教授 2006: 順天堂大学, 医学部, 講師 2005: 順天堂大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Basic Section 38050:Food sciences-related / Eating habits / Integrated Nutrition Science Except Principal Investigator Basic Section 38050:Food sciences-related / Eating habits / Integrated Nutrition Science / Biological Sciences
Keywords	Principal Investigator 血管トーヌス / 高血圧 / マグネシウム欠乏 / 脚気 / ビタミンB1欠乏 / 高血圧症 / マグネシウム欠乏症 / 心不全 / 血管平滑筋 / 血管収縮 … More / 虚血-再灌流障害 / 一酸化窒素合成酵素 / フコイダン / 血管弛緩反応 / 一酸化窒素 / 血管内皮細胞 … More Except Principal Investigator 心機能 / 脚気衝心 / 脚気 / 突然死 / マグネシウム欠乏 / マグネシウム補充 / ミトコンドリア / 低マグネシウム血症 / ビタミンＢ１欠乏 / 心不全 / ビタミンB1欠乏 / 低栄養 / ミトコンドリア透過性遷移孔 / Mg補充 / 心エコー / 血管平滑筋収縮機能 / Ca2+感受性 / 貧血 / TRPM7チャネル / ミトコンドリア透過性遷移孔(mPTP) / 心筋保護 / 虚血再灌流障害 / 心血管機能不全 / 細胞外マトリックス / 平滑筋 / 筋収縮 / カルシウムシグナル / 棟鎖 / マウスモデル / カルシウム / ミオトニア / パールカン / ヘパラン硫酸プロテオグリカン Less

ビタミンB1欠乏時における血管の反応性の変化はマグネシウム欠乏とどう関連するかPrincipal Investigator
- Principal Investigator
  
  家崎貴文
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38050:Food sciences-related
- Research Institution
  Juntendo University
Is the cardiac sudden death by chronic magnesium deficiency associated with beriberi heart failure? Varidation from undernutrition.
- Principal Investigator
  
  渡邉マキノ
- Project Period (FY)
  2019 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38050:Food sciences-related
- Research Institution
  Juntendo University
Elucidation of physiological mechanism(s) of magnesium deficiency-induced hypertensionPrincipal Investigator
- Principal Investigator
  
  IESAKI TAKAFUMI
- Project Period (FY)
  2017 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Eating habits
- Research Institution
  Juntendo University
Investigation of cause of sudden death associated with hypomagnesemia and examination of usefulness of magnesium replacement therapy
- Principal Investigator
  
  Watanabe Makino
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Eating habits
- Research Institution
  Juntendo University
Investigation of the mechanism of nitric oxide production by an extract of brown marine algae and its usefulness as a functional foodPrincipal Investigator
- Principal Investigator
  
  Iesaki Takafumi
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Integrated Nutrition Science
- Research Institution
  Juntendo University
Is the cardiovascular dysfunction with hypomagnesemia improved by magnesium supplemental treatment?
- Principal Investigator
  
  WATANABE Makino
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Integrated Nutrition Science
- Research Institution
  Juntendo University
ヘパラン硫酸プロテオグリカン、パールカンによる筋収縮シグナル制御の研究
- Principal Investigator
  
  平澤恵理
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Juntendo University

All 2022 2021 2019 2018 2017 2016 2015 2014 2013 2006 Other

All Journal Article Presentation

[Journal Article] Chronic magnesium deficiency causes reversible mitochondrial permeability transition pore opening and impairs hypoxia tolerance in the rat heart2022
- Author(s)
  Watanabe Makino、Nakamura Kyoko、Kato Megumi、Okada Takao、Iesaki Takafumi
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 148 Issue: 2 Pages: 238-247
- DOI
  10.1016/j.jphs.2021.12.002
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K05933, KAKENHI-PROJECT-17K00879
[Journal Article] Increased Risk of Aortic Dissection with Perlecan Deficiency2021
- Author(s)
  Nonaka Risa、Iesaki Takafumi、Kerever Aurelien、Arikawa-Hirasawa Eri
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 1 Pages: 315-315
- DOI
  10.3390/ijms23010315
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08089, KAKENHI-PROJECT-22K07543, KAKENHI-PROJECT-17K00879
[Journal Article] 低酸素下における心筋細胞内マグネシウムの維持機構2013
- Author(s)
  華藤恵美、中村京子、家崎貴文、岡田隆夫、代田浩之、渡邉マキノ
- Journal Title
  
  順天堂醫事雑誌
  
  Volume: 59 Pages: 260-266
- NAID
  130004712327
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24614015
[Journal Article] Acarbose, an α-glucosidase inhibitor, improves endothelial dysfunction in Goto-Kakizaki rats exhibiting repetitive blood glucose fluctuation.2006
- Author(s)
  Azuma K, Toyofuku Y, Iesaki T, Otsuka A, Tanaka A, Mita T, Hirose T, Tanaka Y, Daida H, Kawamori R, Watada H
- Journal Title
  
  Biochemical and Biophysical Research Communications 345(2)
  
  Pages: 688-693
- Data Source
  KAKENHI-PROJECT-17046019
[Journal Article] Temporal hyperglycemia provokes monocyte adhesion to endothelial cells in rat thoracic aorta2006
- Author(s)
  Otsuka A, Azuma K, Iesaki T, Sato F, Hirose T, Shimizu T, Tanaka Y, Daida H, Kawamori R, Watada, H
- Journal Title
  
  Diabetologia. 48(12)
- Data Source
  KAKENHI-PROJECT-17046019
[Presentation] Elevation of Diastolic Blood Pressure and Reduction of Vascular Contraction in Magnesium Deficient Rat Model.2019
- Author(s)
  Takafumi Iesaki
- Organizer
  29th European Meeting on Hypertension and Cardiovascular Protection
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K00879
[Presentation] Elevation of Diastolic Blood Pressure and Reduction of Vascular Contraction in Magnesium Deficient Rat Model.2019
- Author(s)
  Takafumi Iesaki, Makino Watanabe
- Organizer
  29th European Meeting on Hypertension and Cardiovascular Protection
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K05933
[Presentation] Magnesium Deficiency Attenuates Vascular Smooth Muscle Contraction in Rat Aorta2018
- Author(s)
  家崎　貴文
- Organizer
  Ｅｘｏｅｒｉｍｅｎｔａｌ　Ｂｉｏｌｏｇｙ　２０１８
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K00879
[Presentation] Functional evaluation of myocardium mitochondria in magnesium deficient rat2018
- Author(s)
  Yuya Ohe, Yuuki Yachida, Ryota Hashimoto, Kyoko Nakamura, Takafumi Iesaki, Makino Watanabe
- Organizer
  第95回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-15K00846
[Presentation] Magnesium Deficiency Attenuates Vascular Smooth Muscle Contraction in Rat Aorta2018
- Author(s)
  家崎　貴文
- Organizer
  experimental Biology 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K00879
[Presentation] Magnesium Deficiency Attenuates Vascular Smooth Muscle Contraction in Rat Aorta2018
- Author(s)
  Takafumi Iesaki, Ryo Kakigi, Makino Watanabe
- Organizer
  Experimental Biology 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K00846
[Presentation] マグネシウム欠乏ラットにおける血管平滑筋収縮の抑制の機序2017
- Author(s)
  宮内翼、竹田安里彩、渡邉マキノ、岡田隆夫、家崎貴文
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎
- Year and Date
  2017-03-15
- Data Source
  KAKENHI-PROJECT-15K00846
[Presentation] Magnesium deficiency inhibits both voltage-gated and receptor-operated vascular smooth muscle contraction.2016
- Author(s)
  Yuki Iwamoto, Shigetaka Fukuda, Shinya Fujioka, Makino Watanabe, Takao Okada, Takafumi Iesaki
- Organizer
  第93回日本生理学会大会
- Place of Presentation
  札幌コンベンションセンター
- Year and Date
  2016-03-23
- Data Source
  KAKENHI-PROJECT-15K00846
[Presentation] 慢性Mg欠乏ラット心臓における低酸素耐性の低下とMg補充効果の検討2015
- Author(s)
  渡邉マキノ、柿木亮、中村京子、華藤恵美、家崎貴文、岡田隆夫
- Organizer
  第25回日本病態生理学会
- Place of Presentation
  愛媛大学城北キャンパス
- Year and Date
  2015-08-01
- Data Source
  KAKENHI-PROJECT-15K00846
[Presentation] Mechanisms of cardioprotective effects of high concentration of magnesium on hypoxia/reoxygenation injury in chronic magnesium deficient rat heart are differ from normal rat heart2014
- Author(s)
  Makino Watanabe, Kyoko Nakamura, Megumi Kato, Ryo Kakigi, Takafumi Iesaki, Takao Okada
- Organizer
  Experimental Biology 2014
- Place of Presentation
  San Diego Convention Center
- Data Source
  KAKENHI-PROJECT-24614015
[Presentation] Mechanisms of cardioprotective effects of high concentration of magnesium on hypoxia/reoxygenation injury in chronic magnesium deficient rat heart are differ from normal rat heart2014
- Author(s)
  Makino Watanabe, Ryo Kakigi, Takafumi Iesaki, Takao Okada
- Organizer
  第91回日本生理学会大会
- Place of Presentation
  鹿児島大学郡元キャンパス
- Data Source
  KAKENHI-PROJECT-24614015
[Presentation] Magnesium Influx Pathway in Cardiomyocytes Under Hypoxic Condition2013
- Author(s)
  Megumi Kato, Kyoko Nakamura, Takafumi Iesaki, Takao Okada, Hiroyuki Daida, Makino Watanabe
- Organizer
  第90回日本生理学会大会
- Place of Presentation
  タワーホール船堀（東京）
- Data Source
  KAKENHI-PROJECT-24614015
[Presentation] Fucoidan, a ligand of scavenger receptor type A, causes vascular relaxation through a nitric oxide/cGMP-mediated pathway in rat aorta.
- Author(s)
  Takafumi Iesaki
- Organizer
  82nd European Atherosclerosis Society (EAS) Congress
- Place of Presentation
  Madrid, Spain
- Year and Date
  2014-05-31 – 2014-06-03
- Data Source
  KAKENHI-PROJECT-25504014
[Presentation] Mechanisms of cardioprotective effects of high magnesium on hypoxia/reoxygenation injury in chronic magnesium deficient rat heart are differ from normal rat heart
- Author(s)
  Makino Watanabe, Kyoko Nakamura, Megumi Kato, Ryo Kakigi, Takafumi Iesaki, Takao Okada
- Organizer
  Experimental Biology 2014
- Place of Presentation
  San Diego Convention Center
- Year and Date
  2014-04-26 – 2014-04-30
- Data Source
  KAKENHI-PROJECT-24614015

1. WATANABE Makino (00255655)

# of Collaborated Projects: 6 results

# of Collaborated Products: 12 results
2. Kakigi Ryo (70614931)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 中村京子 (90578858)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
4. Hashimoto Ryota (60433786)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 平澤恵理 (50245718)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 村山尚 (10230012)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 野中里紗 (90614248)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. ケレベールオーレリアン

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Iesaki Takafumi 家崎 貴文

IESAKI Takafumi 家崎 貴文

家崎 貴文 イエサキ タカフミ

Research Projects

Research Products

Co-Researchers

ビタミンB1欠乏時における血管の反応性の変化はマグネシウム欠乏とどう関連するかPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Is the cardiac sudden death by chronic magnesium deficiency associated with beriberi heart failure? Varidation from undernutrition.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of physiological mechanism(s) of magnesium deficiency-induced hypertensionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation of cause of sudden death associated with hypomagnesemia and examination of usefulness of magnesium replacement therapy

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation of the mechanism of nitric oxide production by an extract of brown marine algae and its usefulness as a functional foodPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Is the cardiovascular dysfunction with hypomagnesemia improved by magnesium supplemental treatment?

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ヘパラン硫酸プロテオグリカン、パールカンによる筋収縮シグナル制御の研究

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Chronic magnesium deficiency causes reversible mitochondrial permeability transition pore opening and impairs hypoxia tolerance in the rat heart2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Increased Risk of Aortic Dissection with Perlecan Deficiency2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 低酸素下における心筋細胞内マグネシウムの維持機構2013

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Acarbose, an α-glucosidase inhibitor, improves endothelial dysfunction in Goto-Kakizaki rats exhibiting repetitive blood glucose fluctuation.2006

Author(s)

Journal Title

Data Source

[Journal Article] Temporal hyperglycemia provokes monocyte adhesion to endothelial cells in rat thoracic aorta2006

Author(s)

Journal Title

Data Source

[Presentation] Elevation of Diastolic Blood Pressure and Reduction of Vascular Contraction in Magnesium Deficient Rat Model.2019

Author(s)

Organizer

Data Source

[Presentation] Elevation of Diastolic Blood Pressure and Reduction of Vascular Contraction in Magnesium Deficient Rat Model.2019

Author(s)

Organizer

Data Source

[Presentation] Magnesium Deficiency Attenuates Vascular Smooth Muscle Contraction in Rat Aorta2018

Iesaki Takafumi 家崎貴文

IESAKI Takafumi 家崎貴文

家崎貴文イエサキタカフミ