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Iesaki Takafumi  家崎 貴文

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IESAKI Takafumi  家崎 貴文

家崎 貴文  イエサキ タカフミ

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Researcher Number 10348956
Other IDs
Affiliation (Current) 2025: 順天堂大学, 保健医療学部, 先任准教授
Affiliation (based on the past Project Information) *help 2019 – 2023: 順天堂大学, 保健医療学部, 先任准教授
2016 – 2018: 順天堂大学, 医学部, 先任准教授
2012 – 2015: 順天堂大学, 医学部, 准教授
2006: 順天堂大学, 医学部, 講師
2005: 順天堂大学, 医学部, 助手
Review Section/Research Field
Principal Investigator
Basic Section 38050:Food sciences-related / Eating habits / Integrated Nutrition Science
Except Principal Investigator
Basic Section 38050:Food sciences-related / Eating habits / Integrated Nutrition Science / Biological Sciences
Keywords
Principal Investigator
血管トーヌス / 高血圧 / マグネシウム欠乏 / 脚気 / ビタミンB1欠乏 / 高血圧症 / マグネシウム欠乏症 / 心不全 / 血管平滑筋 / 血管収縮 … More / 虚血-再灌流障害 / 一酸化窒素合成酵素 / フコイダン / 血管弛緩反応 / 一酸化窒素 / 血管内皮細胞 … More
Except Principal Investigator
心機能 / 脚気衝心 / 脚気 / 突然死 / マグネシウム欠乏 / マグネシウム補充 / ミトコンドリア / 低マグネシウム血症 / ビタミンB1欠乏 / 心不全 / ビタミンB1欠乏 / 低栄養 / ミトコンドリア透過性遷移孔 / Mg補充 / 心エコー / 血管平滑筋収縮機能 / Ca2+感受性 / 貧血 / TRPM7チャネル / ミトコンドリア透過性遷移孔(mPTP) / 心筋保護 / 虚血再灌流障害 / 心血管機能不全 / 細胞外マトリックス / 平滑筋 / 筋収縮 / カルシウムシグナル / 棟鎖 / マウスモデル / カルシウム / ミオトニア / パールカン / ヘパラン硫酸プロテオグリカン Less
  • Research Projects

    (7 results)
  • Research Products

    (19 results)
  • Co-Researchers

    (8 People)
  •  ビタミンB1欠乏時における血管の反応性の変化はマグネシウム欠乏とどう関連するかPrincipal Investigator

    • Principal Investigator
      家崎 貴文
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 38050:Food sciences-related
    • Research Institution
      Juntendo University
  •  Is the cardiac sudden death by chronic magnesium deficiency associated with beriberi heart failure? Varidation from undernutrition.

    • Principal Investigator
      渡邉 マキノ
    • Project Period (FY)
      2019 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 38050:Food sciences-related
    • Research Institution
      Juntendo University
  •  Elucidation of physiological mechanism(s) of magnesium deficiency-induced hypertensionPrincipal Investigator

    • Principal Investigator
      IESAKI TAKAFUMI
    • Project Period (FY)
      2017 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Eating habits
    • Research Institution
      Juntendo University
  •  Investigation of cause of sudden death associated with hypomagnesemia and examination of usefulness of magnesium replacement therapy

    • Principal Investigator
      Watanabe Makino
    • Project Period (FY)
      2015 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Eating habits
    • Research Institution
      Juntendo University
  •  Investigation of the mechanism of nitric oxide production by an extract of brown marine algae and its usefulness as a functional foodPrincipal Investigator

    • Principal Investigator
      Iesaki Takafumi
    • Project Period (FY)
      2013 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Integrated Nutrition Science
    • Research Institution
      Juntendo University
  •  Is the cardiovascular dysfunction with hypomagnesemia improved by magnesium supplemental treatment?

    • Principal Investigator
      WATANABE Makino
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Integrated Nutrition Science
    • Research Institution
      Juntendo University
  •  ヘパラン硫酸プロテオグリカン、パールカンによる筋収縮シグナル制御の研究

    • Principal Investigator
      平澤 恵理
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Juntendo University

All 2022 2021 2019 2018 2017 2016 2015 2014 2013 2006 Other

All Journal Article Presentation

  • [Journal Article] Chronic magnesium deficiency causes reversible mitochondrial permeability transition pore opening and impairs hypoxia tolerance in the rat heart2022

    • Author(s)
      Watanabe Makino、Nakamura Kyoko、Kato Megumi、Okada Takao、Iesaki Takafumi
    • Journal Title

      Journal of Pharmacological Sciences

      Volume: 148 Issue: 2 Pages: 238-247

    • DOI

      10.1016/j.jphs.2021.12.002

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K05933, KAKENHI-PROJECT-17K00879
  • [Journal Article] Increased Risk of Aortic Dissection with Perlecan Deficiency2021

    • Author(s)
      Nonaka Risa、Iesaki Takafumi、Kerever Aurelien、Arikawa-Hirasawa Eri
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 23 Issue: 1 Pages: 315-315

    • DOI

      10.3390/ijms23010315

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K08089, KAKENHI-PROJECT-22K07543, KAKENHI-PROJECT-17K00879
  • [Journal Article] 低酸素下における心筋細胞内マグネシウムの維持機構2013

    • Author(s)
      華藤恵美、中村京子、家崎貴文、岡田隆夫、代田浩之、渡邉マキノ
    • Journal Title

      順天堂醫事雑誌

      Volume: 59 Pages: 260-266

    • NAID

      130004712327

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24614015
  • [Journal Article] Acarbose, an α-glucosidase inhibitor, improves endothelial dysfunction in Goto-Kakizaki rats exhibiting repetitive blood glucose fluctuation.2006

    • Author(s)
      Azuma K, Toyofuku Y, Iesaki T, Otsuka A, Tanaka A, Mita T, Hirose T, Tanaka Y, Daida H, Kawamori R, Watada H
    • Journal Title

      Biochemical and Biophysical Research Communications 345(2)

      Pages: 688-693

    • Data Source
      KAKENHI-PROJECT-17046019
  • [Journal Article] Temporal hyperglycemia provokes monocyte adhesion to endothelial cells in rat thoracic aorta2006

    • Author(s)
      Otsuka A, Azuma K, Iesaki T, Sato F, Hirose T, Shimizu T, Tanaka Y, Daida H, Kawamori R, Watada, H
    • Journal Title

      Diabetologia. 48(12)

    • Data Source
      KAKENHI-PROJECT-17046019
  • [Presentation] Elevation of Diastolic Blood Pressure and Reduction of Vascular Contraction in Magnesium Deficient Rat Model.2019

    • Author(s)
      Takafumi Iesaki
    • Organizer
      29th European Meeting on Hypertension and Cardiovascular Protection
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K00879
  • [Presentation] Elevation of Diastolic Blood Pressure and Reduction of Vascular Contraction in Magnesium Deficient Rat Model.2019

    • Author(s)
      Takafumi Iesaki, Makino Watanabe
    • Organizer
      29th European Meeting on Hypertension and Cardiovascular Protection
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K05933
  • [Presentation] Magnesium Deficiency Attenuates Vascular Smooth Muscle Contraction in Rat Aorta2018

    • Author(s)
      家崎 貴文
    • Organizer
      Exoerimental Biology 2018
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K00879
  • [Presentation] Functional evaluation of myocardium mitochondria in magnesium deficient rat2018

    • Author(s)
      Yuya Ohe, Yuuki Yachida, Ryota Hashimoto, Kyoko Nakamura, Takafumi Iesaki, Makino Watanabe
    • Organizer
      第95回日本生理学会大会
    • Data Source
      KAKENHI-PROJECT-15K00846
  • [Presentation] Magnesium Deficiency Attenuates Vascular Smooth Muscle Contraction in Rat Aorta2018

    • Author(s)
      家崎 貴文
    • Organizer
      experimental Biology 2018
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K00879
  • [Presentation] Magnesium Deficiency Attenuates Vascular Smooth Muscle Contraction in Rat Aorta2018

    • Author(s)
      Takafumi Iesaki, Ryo Kakigi, Makino Watanabe
    • Organizer
      Experimental Biology 2018
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K00846
  • [Presentation] マグネシウム欠乏ラットにおける血管平滑筋収縮の抑制の機序2017

    • Author(s)
      宮内翼、竹田安里彩、渡邉マキノ、岡田隆夫、家崎貴文
    • Organizer
      第90回日本薬理学会年会
    • Place of Presentation
      長崎
    • Year and Date
      2017-03-15
    • Data Source
      KAKENHI-PROJECT-15K00846
  • [Presentation] Magnesium deficiency inhibits both voltage-gated and receptor-operated vascular smooth muscle contraction.2016

    • Author(s)
      Yuki Iwamoto, Shigetaka Fukuda, Shinya Fujioka, Makino Watanabe, Takao Okada, Takafumi Iesaki
    • Organizer
      第93回日本生理学会大会
    • Place of Presentation
      札幌コンベンションセンター
    • Year and Date
      2016-03-23
    • Data Source
      KAKENHI-PROJECT-15K00846
  • [Presentation] 慢性Mg欠乏ラット心臓における低酸素耐性の低下とMg補充効果の検討2015

    • Author(s)
      渡邉マキノ、柿木亮、中村京子、華藤恵美、家崎貴文、岡田隆夫
    • Organizer
      第25回日本病態生理学会
    • Place of Presentation
      愛媛大学城北キャンパス
    • Year and Date
      2015-08-01
    • Data Source
      KAKENHI-PROJECT-15K00846
  • [Presentation] Mechanisms of cardioprotective effects of high concentration of magnesium on hypoxia/reoxygenation injury in chronic magnesium deficient rat heart are differ from normal rat heart2014

    • Author(s)
      Makino Watanabe, Kyoko Nakamura, Megumi Kato, Ryo Kakigi, Takafumi Iesaki, Takao Okada
    • Organizer
      Experimental Biology 2014
    • Place of Presentation
      San Diego Convention Center
    • Data Source
      KAKENHI-PROJECT-24614015
  • [Presentation] Mechanisms of cardioprotective effects of high concentration of magnesium on hypoxia/reoxygenation injury in chronic magnesium deficient rat heart are differ from normal rat heart2014

    • Author(s)
      Makino Watanabe, Ryo Kakigi, Takafumi Iesaki, Takao Okada
    • Organizer
      第91回日本生理学会大会
    • Place of Presentation
      鹿児島大学郡元キャンパス
    • Data Source
      KAKENHI-PROJECT-24614015
  • [Presentation] Magnesium Influx Pathway in Cardiomyocytes Under Hypoxic Condition2013

    • Author(s)
      Megumi Kato, Kyoko Nakamura, Takafumi Iesaki, Takao Okada, Hiroyuki Daida, Makino Watanabe
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      タワーホール船堀(東京)
    • Data Source
      KAKENHI-PROJECT-24614015
  • [Presentation] Fucoidan, a ligand of scavenger receptor type A, causes vascular relaxation through a nitric oxide/cGMP-mediated pathway in rat aorta.

    • Author(s)
      Takafumi Iesaki
    • Organizer
      82nd European Atherosclerosis Society (EAS) Congress
    • Place of Presentation
      Madrid, Spain
    • Year and Date
      2014-05-31 – 2014-06-03
    • Data Source
      KAKENHI-PROJECT-25504014
  • [Presentation] Mechanisms of cardioprotective effects of high magnesium on hypoxia/reoxygenation injury in chronic magnesium deficient rat heart are differ from normal rat heart

    • Author(s)
      Makino Watanabe, Kyoko Nakamura, Megumi Kato, Ryo Kakigi, Takafumi Iesaki, Takao Okada
    • Organizer
      Experimental Biology 2014
    • Place of Presentation
      San Diego Convention Center
    • Year and Date
      2014-04-26 – 2014-04-30
    • Data Source
      KAKENHI-PROJECT-24614015
  • 1.  WATANABE Makino (00255655)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 12 results
  • 2.  Kakigi Ryo (70614931)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 3.  中村 京子 (90578858)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 3 results
  • 4.  Hashimoto Ryota (60433786)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  平澤 恵理 (50245718)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  村山 尚 (10230012)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  野中 里紗 (90614248)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  ケレベール オーレリアン
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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