Kubota Yoshitaka 窪田吉孝

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KUBOTA Yoshitaka 窪田吉孝

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Researcher Number	10375735
Other IDs
Affiliation (Current)	2025: 千葉大学, 大学院医学研究院, 准教授
Affiliation (based on the past Project Information) *help	2020 – 2024: 千葉大学, 大学院医学研究院, 准教授 2017 – 2019: 千葉大学, 大学院医学研究院, 講師 2014 – 2016: 千葉大学, 医学部附属病院, 講師 2011 – 2013: 千葉大学, 医学部附属病院, 助教
Review Section/Research Field	Principal Investigator Basic Section 56070:Plastic and reconstructive surgery-related / Plastic surgery / Metabolomics Except Principal Investigator Basic Section 56070:Plastic and reconstructive surgery-related / Plastic surgery / Basic Section 55010:General surgery and pediatric surgery-related / Metabolomics
Keywords	Principal Investigator 脂肪移植 / エピジェネティクス / 皮下脂肪 / 脂肪細胞 / DNAメチル化 / 機械学習 / 大量データ / シングルセル解析 / 体性幹細胞 / 多分化能 … More / ヒストン修飾 / マシーンラーニング / メタボリックシンドローム / メチル化 / 皮下脂肪組織 / 細胞分化 / 脂肪組織 / アクアポリン / 移植学 / 組織培養 … More Except Principal Investigator 脂肪細胞 / 脂肪移植 / エピジェネティクス / 移植 / ex vivo遺伝子治療 / 脂肪 / 機械学習 / 骨延長 / 仮骨延長 / 骨延長術 / 脂肪組織 / 脂肪幹細胞 / 細胞障害ストレス / 過剰発現 / 老化 / HIVEP3 / WNTシグナル / 頭蓋顎顔面変形症 / シングルセル解析 / アンチエイジング / 分化 / 一細胞解析 / 創傷 / ex vivo 遺伝子治療 / 生着率向上 / 天井培養法 / 移植床 / 組織拡張器 / 遊離脂肪移植 / 組織内圧 / 脂肪組織由来幹細胞 / メカノトランスダクション / 陰圧閉鎖療法 / 前脂肪細胞 / 遺伝子治療 / 抗体療法 / 乳癌 / 再生医療 / 骨新生 / 加工 / 輸送 / 前駆脂肪細胞 / チタン / 顔面骨 / 生体反応 / 光触媒 / 骨再生 / 遺伝子 / DNAメチル化 / 細胞分化 / 細胞移植 / BDNF / アルツハイマー病 / アミロイドβ / アルツハイマー / ネプリライシン / アルツハイマー認知症 Less

年代別によるヒト脂肪細胞の違いと、ヒト脂肪細胞への遺伝子導入に関する研究
- Principal Investigator
  
  山田香穂子
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56070:Plastic and reconstructive surgery-related
- Research Institution
  Chiba University
Development of adipocytes for gene therapy that avoids cellular stress due to overexpression of therapeutic proteins
- Principal Investigator
  
  黒田正幸
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56070:Plastic and reconstructive surgery-related
- Research Institution
  Chiba University
冷却刺激誘導ベージュ(beige)脂肪細胞を用いた新しい脂肪移植法の確立
- Principal Investigator
  
  三川信之
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56070:Plastic and reconstructive surgery-related
- Research Institution
  Chiba University
転写因子Hivep3による骨芽細胞制御機構と頭蓋顎顔面変形症への関与
- Principal Investigator
  
  新井美波
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56070:Plastic and reconstructive surgery-related
- Research Institution
  Chiba University
Development of Innovative Fat Transplantation Based on Single Cell Analysis and Computational Biology of Subcutaneous Adipose Tissue-Derived CellsPrincipal Investigator
- Principal Investigator
  
  窪田吉孝
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56070:Plastic and reconstructive surgery-related
- Research Institution
  Chiba University
Study on improvement of transplantation efficiency of adipocyte gene therapy product by approach from engrafted cells after transplantation
- Principal Investigator
  
  Kuroda Masayuki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56070:Plastic and reconstructive surgery-related
- Research Institution
  Chiba University
Fundamental Research for the Development of Innovative Fat Transplantation Therapies Using Epigenetic Editing Techniques
- Principal Investigator
  
  Mitsukawa Nobuyuki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56070:Plastic and reconstructive surgery-related
- Research Institution
  Chiba University
Establishment of epignenetic genome-edited adipocyte for multiple purposesPrincipal Investigator
- Principal Investigator
  
  窪田吉孝
- Project Period (FY)
  2019 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56070:Plastic and reconstructive surgery-related
- Research Institution
  Chiba University
Exploration of the optimal tissue internal pressure and the preparation methods of the environment in transplant bed tissue in free fat injection.
- Principal Investigator
  
  KURIYAMA MOTONE
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56070:Plastic and reconstructive surgery-related
- Research Institution
  Southen Tohoku Research Institute for Neuroscience
Antibody therapy using gene-transduced adipocytes for breast cancer
- Principal Investigator
  
  Fujimoto Hiroshi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Chiba University
Establishment of transport / transplant formulation based on gene expression transition analysis in culture process of cultured preadipocytes
- Principal Investigator
  
  Kuroda Masayuki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Plastic surgery
- Research Institution
  Chiba University
Epigenetics of osteogenesis related genes in adipocyte for cell transplantaion in distraction osteogenesis
- Principal Investigator
  
  Mitsukawa Nobuyuki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Plastic surgery
- Research Institution
  Chiba University
Cellular functional diffrences of adipocytes between superfical and deep subcutaneous fat layerPrincipal Investigator
- Principal Investigator
  
  KUBOTA YOSHITAKA
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Plastic surgery
- Research Institution
  Chiba University
Accleration of osteogenesis in distraction osteogenesis with gene transfected cells
- Principal Investigator
  
  MITSUKAWA NOBUYUKI
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Plastic surgery
- Research Institution
  Chiba University
Photocatalysis in the body with the electromagnetic wave in passivity film (TiO2) of osteosynthesis materials made by titanium
- Principal Investigator
  
  SATO Kaneshige
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Plastic surgery
- Research Institution
  Chiba University
Elucidation of restoration mechanisms in Alzheimer diseases by mobilized stem cells through activation of adipose tissue
- Principal Investigator
  
  KURODA Masayuki
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Chiba University
Difference of adipocyte function between superficial and deep subcutaneous fat tissuePrincipal Investigator
- Principal Investigator
  
  KUBOTA Yoshitaka
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Metabolomics
- Research Institution
  Chiba University
The role of aquaporin in the mechanism of adipocyte graft survivalPrincipal Investigator
- Principal Investigator
  
  KUBOTA Yoshitaka
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Plastic surgery
- Research Institution
  Chiba University

All 2024 2023 2022 2020 2018 2015 2013 2012 2011 Other

All Journal Article Presentation

[Journal Article] Ex vivo dual gene therapy using human adipocytes secreting anti-HER2 antibody on HER2-positive xenograft tumor models2023
- Author(s)
  Teranaka Ryotaro、Fujimoto Hiroshi、Masuda Takahito、Kuroda Masayuki、Aoyagi Yasuyuki、Nagashima Takeshi、Takada Mamoru、Sakakibara Junta、Yamada Hideyuki、Yamamoto Hiroto、Kubota Yoshitaka、Ohtsuka Masayuki
- Journal Title
  
  Breast Cancer
  
  Volume: 30 Issue: 6 Pages: 1018-1027
- DOI
  10.1007/s12282-023-01497-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08638, KAKENHI-PROJECT-23K27756
[Journal Article] LCAT-trial-24 weeks: Protocol for a clinical study to evaluate the safety of regenerative medicine and gene therapy by the autologous transplantation of human lecithin:cholesterol acyltransferase gene-transduced human pre-adipocytes2022
- Author(s)
  Kuroda Masayuki、Hori Makoto、Maezawa Yoshiro、Kubota Yoshitaka、Mitsukawa Nobuyuki、Shiko Yuki、Ozawa Yoshihito、Kawasaki Yohei、Saito Yasushi、Hanaoka Hideki、Yokote Koutaro
- Journal Title
  
  Contemporary Clinical Trials Communications
  
  Volume: 28 Pages: 100946-100946
- DOI
  10.1016/j.conctc.2022.100946
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03572, KAKENHI-PROJECT-20K09859
[Journal Article] First-in-human autologous implantation of genetically modified adipocytes expressing LCAT for the treatment of familial LCAT deficiency2022
- Author(s)
  Aso Masayuki、Yamamoto Tokuo T.、Kuroda Masayuki、Wada Jun、Kubota Yoshitaka、Ishikawa Ko、Maezawa Yoshiro、
- Journal Title
  
  Heliyon
  
  Volume: 8 Issue: 11 Pages: e11271-e11271
- DOI
  10.1016/j.heliyon.2022.e11271
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03572, KAKENHI-PROJECT-20K09859
[Journal Article] Anti-HER2 antibody therapy using gene-transduced adipocytes for HER2-positive breast cancer2020
- Author(s)
  Takahito Masuda, Hiroshi Fujimoto, Ryotaro Teranaka, Masayuki Kuroda, Yasuyuki, Aoyagi, Takeshi Nagashima, Takafumi Sangai, Mamoru Takada, Ayako, Nakagawa, Yoshitaka Kubota, Koutaro Yokote, Masayuki Ohtsuka
- Journal Title
  
  Breast Cancer Research and Treatment
  
  Volume: 180 Issue: 3 Pages: 625-634
- DOI
  10.1007/s10549-020-05581-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08588
[Presentation] LCAT-GMACによる家族性LCAT欠損症を対象としたex vivo遺伝子治療のfirst in human試験2024
- Author(s)
  黒田正幸、前澤善朗、和田淳、窪田吉孝、三川信之、山本徳男、麻生雅是、花岡英紀、齋藤康、横手幸太郎
- Organizer
  第23回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-23K27756
[Presentation] One and Done Gene and Cell Therapy for Familial LCAT Deficiency Using LCAT Gene Transduced Human Adipocytes.2023
- Author(s)
  Aso M, Yamamoto TT, Kuroda M, Wada J, Kubota Y, Ishikawa K, Maezawa Y, Teramoto N, Tawada A, Asada S, Aoyagi Y, Kirinashizawa M, Onitake A, Matsuura Y, Yasunaga K, Konno S, Nishino K, Yamamoto M, Miyoshi J, Kobayashi N, Tanio M, Ikeuchi T, Igari H, Mitsukawa N, Hanaoka H, Yokote K, Saito Y.
- Organizer
  The American Society of Gene & Cell Therapy (ASGCT), 26th Annual Meeting.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27756
[Presentation] Sustained LCAT replacement in patient with familial LCAT deficiency in clinical trial of ex vivo gene/cell therapy using autologous preadipocytes.2023
- Author(s)
  Kuroda M, Aso M, Yamamoto TT, Wada J, Ishikawa K, Maezawa Y, Teramoto N, Kubota Y, Tawada A, Aoyagi Y, Asada S, Kirinashizawa M, Onitake A, Matsuura Y, Yasunaga K, Konno S, Nishino K, Yamamoto M, Miyoshi J, Kobayashi N, Tanio M, Ikeuchi T, Igari H, Mitsukawa N, Hanaoka H, Saito Y, Yokote K.
- Organizer
  ESGCT 30TH ANNUAL CONGRESS
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27756
[Presentation] 家族性LCAT欠損症を対象としたex vivo脂肪細胞遺伝子治療のfirst in human試験2023
- Author(s)
  黒田正幸、石川耕、前澤善朗、和田淳、窪田吉孝、三川信之、太和田彩子、山本徳男、麻生雅是、花岡英紀、齋藤康、横手幸太郎
- Organizer
  第29回日本遺伝子細胞治療学会学術集会
- Data Source
  KAKENHI-PROJECT-23K27756
[Presentation] 家族性LCAT欠損症を対象としたLCAT遺伝子導入脂肪細胞（LCAT-GMAC）による治療2020
- Author(s)
  黒田正幸、石川耕、前澤善朗、三川信之、窪田吉孝、青栁靖之、浅田咲世、鬼武彰宣、切無澤美香、和田淳、山本徳男、花岡英紀、麻生雅是、齋藤康、横手幸太郎.
- Organizer
  第52回日本動脈硬化学会総会・学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-17K11530
[Presentation] LCAT遺伝子導入脂肪細胞（LCAT-GMAC）による家族性LCAT欠損症の治療2020
- Author(s)
  黒田正幸、石川耕、前澤善朗、三川信之、窪田吉孝、青栁靖之、浅田咲世、鬼武彰宣、切無澤美香、和田淳、山本　徳男、花岡英紀、麻生雅是、齋藤康、横手幸太郎
- Organizer
  第52回日本動脈硬化学会総会・学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-20K09859
[Presentation] First in human clinical trial of treatment of familial LCAT deficiency syndrome by self-transplantation of therapeutic-enzyme secreting adipocytes.2018
- Author(s)
  Kuroda M, Ishikawa K, Kubota Y, Mitsukawa N, Tawada A, Aoyagi Y, Asada S, Yamamoto T, Konno S, Tanaka S, Tanio M, Aso M, Saito Y, Wada J. Yokote K.
- Organizer
  25th TERMIS (Tissue Engineering and Regenerative Medicine International Society) World Congress.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11530
[Presentation] チタン製骨接合材料の不導体における電磁波による生体内光触媒作用2015
- Author(s)
  吉良智恵　窪田吉孝　佐藤兼重
- Organizer
  第58回日本形成外科学会総会
- Place of Presentation
  京都府京都市ウェスティン都ホテル
- Year and Date
  2015-04-08
- Data Source
  KAKENHI-PROJECT-26670770
[Presentation] Ex vivo遺伝子導入した脂肪細胞移植による難治性・希少疾患治療の展望2013
- Author(s)
  窪田吉孝
- Organizer
  第22回日本形成外科学会基礎学術集会
- Place of Presentation
  新潟
- Data Source
  KAKENHI-PROJECT-25870138
[Presentation] The role of aquaporin under hypoxic condition in early stage of adipocyte transplantation2012
- Author(s)
  Yoshitaka Kubota
- Organizer
  4th Congress of the World Union of Wound Healing Society
- Place of Presentation
  Yokohama , Japan
- Data Source
  KAKENHI-PROJECT-23792036
[Presentation] The role of aquaporin under hypoxic condition in early stage of adipocyte transplantation2012
- Author(s)
  Yoshitaka Kubota
- Organizer
  4^<th> Congress of the World Union ofWound
- Place of Presentation
  Yokohama, Japan
- Data Source
  KAKENHI-PROJECT-23792036
[Presentation] 皮下組織浅層・深層の機能的差異の解析研究2012
- Author(s)
  窪田吉孝、三川信之、小坂健太朗、安達直樹、秋田新介、力久直昭、黒田正幸、武城英明、佐藤兼重
- Organizer
  第21回日本形成外科学会基礎学術集会
- Place of Presentation
  福島
- Data Source
  KAKENHI-PROJECT-23792036
[Presentation] 移植脂肪細胞の生着の機序とその修飾法の探求2011
- Author(s)
  窪田吉孝
- Organizer
  第20回日本形成外科学会基礎学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23792036
[Presentation] 皮下脂肪組織由来細胞の部位特異的機能差とエピジェネティクス解析
- Author(s)
  窪田吉孝
- Organizer
  第23回日本形成外科学会基礎学術集会
- Place of Presentation
  長野県松本市　キッセイ文化ホール
- Year and Date
  2014-10-09 – 2014-10-10
- Data Source
  KAKENHI-PROJECT-25870138

1. MITSUKAWA NOBUYUKI (40595196)

# of Collaborated Projects: 10 results

# of Collaborated Products: 0 results
2. KURODA Masayuki (00253005)

# of Collaborated Projects: 9 results

# of Collaborated Products: 8 results
3. 田中知明 (50447299)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. SATO Kaneshige (50138442)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
5. 新井美波 (70790260)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. BUJO Hideaki (80291300)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. Fujimoto Hiroshi (60456027)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. KURIYAMA MOTONE (40457388)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 秋田新介 (00436403)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 三階貴史 (00375685)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. 長嶋健 (60292710)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
12. 大塚将之 (90334185)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
13. 山田香穂子 (50993838)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 吉岡和香子 (30870802)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 前澤善朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
16. 榊原淳太

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 高田護

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kubota Yoshitaka 窪田 吉孝

KUBOTA Yoshitaka 窪田 吉孝

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Development of Innovative Fat Transplantation Based on Single Cell Analysis and Computational Biology of Subcutaneous Adipose Tissue-Derived CellsPrincipal Investigator

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Establishment of epignenetic genome-edited adipocyte for multiple purposesPrincipal Investigator

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Cellular functional diffrences of adipocytes between superfical and deep subcutaneous fat layerPrincipal Investigator

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Kubota Yoshitaka 窪田吉孝

KUBOTA Yoshitaka 窪田吉孝