Nagashima Takeshi 長嶋健

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NAGASHIMA Takeshi 長嶋健

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Researcher Number	60292710
Other IDs
Affiliation (Current)	2025: 千葉大学, 医学部附属病院, 准教授
Affiliation (based on the past Project Information) *help	2013 – 2023: 千葉大学, 医学部附属病院, 准教授 2014: 千葉大学医学部附属病院, 臓器制御外科学, 准教授 2011 – 2012: 千葉大学, 医学部附属病院, 講師 2010: 千葉大学, 医学部附属病院, 助教
Review Section/Research Field	Except Principal Investigator General surgery / Basic Section 55010:General surgery and pediatric surgery-related / Biological pharmacy
Keywords	Except Principal Investigator 乳癌 / 乳腺外科学 / 拡張現実 / 手術支援 / estrogen signal / endocrine therapy / animal model / breast cancer / エストロゲン抵抗性 / Luminal type … More / 新規抗がん剤 / 有害事象 / 増殖抑制効果 / 抗腫瘍効果 / 染色体不安定性 / 創薬 / 小分子 / 動物モデル / 抗がん剤 / ストレスキナーゼ / 微小管重合 / 細胞分裂 / 小分子医薬 / 微小管阻害剤 / 前脂肪細胞 / 遺伝子治療 / 抗体療法 / バイオマーカ― / 非浸潤性乳癌 / 脂肪細胞 / 癌間質相互作用 / テネイシンC / 化学療法抵抗性 / ニッチ / 治療抵抗性 / 細胞外マトリックス / トランスポーター / 分子生物学的研究 / エストロゲン受容体 / 乳がん / エストロゲン前駆体 / 有機アニオン輸送ポリペプチド / ｾﾝﾁﾈﾙﾘﾝﾊﾟ節 / 細胞間マトリックス / プロテオミクス / Tenascin C / ALDH1 / 環境移植 / シナプス / 癌幹細胞ニッチ / ホスト環境 / 転移性乳癌 Less

拡張現実と疑似体位画像生成技術を応用した乳癌術前・術中支援システムの開発
- Principal Investigator
  
  藤本浩司
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Chiba University
in vivoエストロゲン非依存性乳癌細胞株による内分泌療法抵抗性機序の解析研究
- Principal Investigator
  
  山田英幸
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Chiba University
Novel Therapeutic Strategies for Refractory Breast Cancer by Antioxidants with Dual Functions
- Principal Investigator
  
  Takada Mamoru
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Chiba University
Antibody therapy using gene-transduced adipocytes for breast cancer
- Principal Investigator
  
  Fujimoto Hiroshi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Chiba University
Comprehensive gene and protein analysis of ductal carcinoma in situ for novel prognostic biomarkers
- Principal Investigator
  
  Sangai Takafumi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Chiba University
Correlation of Extra cellular matrix as niche to chemo-resistance in breast cancer patients
- Principal Investigator
  
  SAKAKIBARA Masahiro
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Chiba University
Characterization of cancer-associated adipocytes and evaluation of its role in breast cancer
- Principal Investigator
  
  FUJIMOTO Hiroshi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Saitama Medical University
  Chiba University
腫瘍免疫応答を用いた腋窩リンパ節転移陽性乳癌の腋窩ステージング
- Principal Investigator
  
  鈴木ティベリュウ浩志
- Project Period (FY)
  2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Chiba University
Impact of transporters for uptake of estrogen precursors on progression of breast cancer cells
- Principal Investigator
  
  JUN Matsumoto
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Biological pharmacy
- Research Institution
  International University of Health and Welfare
The responsiveness of ALDH1-positive cells to chemotherapy in metastatic lesions and its prognostic significance in patients with breast cancer
- Principal Investigator
  
  SAKAKIBARA Masahiro
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Chiba University

All 2023 2021 2020 2016 2015 2012 Other

All Journal Article Presentation

[Journal Article] Ex vivo dual gene therapy using human adipocytes secreting anti-HER2 antibody on HER2-positive xenograft tumor models2023
- Author(s)
  Teranaka Ryotaro、Fujimoto Hiroshi、Masuda Takahito、Kuroda Masayuki、Aoyagi Yasuyuki、Nagashima Takeshi、Takada Mamoru、Sakakibara Junta、Yamada Hideyuki、Yamamoto Hiroto、Kubota Yoshitaka、Ohtsuka Masayuki
- Journal Title
  
  Breast Cancer
  
  Volume: 30 Issue: 6 Pages: 1018-1027
- DOI
  10.1007/s12282-023-01497-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08638, KAKENHI-PROJECT-23K27756
[Journal Article] A review of MRI (CT)/US fusion imaging in treatment of breast cancer2023
- Author(s)
  Sakakibara Junta、Nagashima Takeshi、Fujimoto Hiroshi、Takada Mamoru、Ohtsuka Masayuki
- Journal Title
  
  Journal of Medical Ultrasonics
  
  Volume: 50 Issue: 3 Pages: 367-373
- DOI
  10.1007/s10396-023-01316-9
- Data Source
  KAKENHI-PROJECT-21K08638
[Journal Article] Less necessity of adjuvant S‐1 treatment in <scp>non‐monarchE</scp>‐eligible patients2023
- Author(s)
  Yu Muhan、Takada Mamoru、Yamada Hideyuki、Fujimoto Hiroshi、Sakakibara Junta、Yamamoto Hiroto、Nagashima Takeshi、Ohtsuka Masayuki
- Journal Title
  
  Cancer Medicine
  
  Volume: 12 Issue: 12 Pages: 13193-13203
- DOI
  10.1002/cam4.6006
- Data Source
  KAKENHI-PROJECT-21K08638
[Journal Article] Practical approach to prevent COVID-19 infection at breast cancer screening2021
- Author(s)
  Takada Mamoru、Tanaka Gaku、Hashimoto Hideyuki、Hirai Yasuyuki、Fukushima Taichi、Nagashima Takeshi、Otsuka Masayuki、Imazeki Fumio
- Journal Title
  
  Breast Cancer
  
  Volume: 28 Issue: 4 Pages: 969-976
- DOI
  10.1007/s12282-021-01235-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16824, KAKENHI-PROJECT-21K08638
[Journal Article] Anti-HER2 antibody therapy using gene-transduced adipocytes for HER2-positive breast cancer2020
- Author(s)
  Takahito Masuda, Hiroshi Fujimoto, Ryotaro Teranaka, Masayuki Kuroda, Yasuyuki, Aoyagi, Takeshi Nagashima, Takafumi Sangai, Mamoru Takada, Ayako, Nakagawa, Yoshitaka Kubota, Koutaro Yokote, Masayuki Ohtsuka
- Journal Title
  
  Breast Cancer Research and Treatment
  
  Volume: 180 Issue: 3 Pages: 625-634
- DOI
  10.1007/s10549-020-05581-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08588
[Journal Article] Organic anion transporting polypeptide 2B1 expression correlates with uptake of estrone-3-sulfate and cell proliferation in estrogen receptor-positive breast cancer cells2015
- Author(s)
  Jun Matsumoto, Noritaka Ariyoshi, Masahiro Sakakibara, Takeo Nakanishi, Yoshiyuki Okubo, Nobumitsu Shiina, Kaoru Fujisaki, Takeshi Nagashima, Yukio Nakatani, Ikumi Tamai, Harumi Yamada, Hiroshi Takeda and Itsuko Ishii
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 30 Issue: 2 Pages: 133-141
- DOI
  10.1016/j.dmpk.2014.10.005
- NAID
  210000170465
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25893224
[Journal Article] Cancer-mediated adipose reversion promotes cancer cell migration via IL-6 and MCP-12015
- Author(s)
  Kaoru Fujisaki,Hiroshi Fujimoto, Takafumi Sangai, Takeshi Nagashima, Masahiro Sakakibara, Nobumitsu Shiina, Masayuki Kuroda, Yasuyuki Aoyagi, Masaru Miyazaki
- Journal Title
  
  Breast Cancer Research and Treatment
  
  Volume: 150 Issue: 2 Pages: 255-263
- DOI
  10.1007/s10549-015-3318-2
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26461942
[Journal Article] ALDH1-positive cells in axillary lymph node metastases after chemotherapy as a prognostic factor in patients with node-positive breast cancer2012
- Author(s)
  Masahiro Sakakibara, Toshihiko Fujimori, Tetsutaro Miyoshi, Takeshi Nagashima, Hiroshi Fujimoto, Hiroshi Tiberu Suzuki, Yohsuke Ohki, Koya Fushimi, Jissei Yokomizo, Yukio Nakatani and Masaru Miyazaki
- Journal Title
  
  Cancer
  
  Volume: 118(16) Pages: 3899-910
- Data Source
  KAKENHI-PROJECT-22591423
[Presentation] タブレット端末を用いた拡張現実(AR)による乳癌手術支援システム2023
- Author(s)
  藤本浩司, 長嶋健, 高田護, 榊原淳太, 山田英幸, 山本寛人, 粕谷雅晴, 佐久間結, 年光亜水, 中口俊哉, 黒田嘉宏, 那須克宏, 大塚将之
- Organizer
  日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-23K08084
[Presentation] Discovery of CMPD1 as a tumor-specific cytotoxic microtubule inhibitor2023
- Author(s)
  Mamoru Takada, Yu-Chia Chen, Wang Junchiao, Hideyuki Yamada, Muhan Yu, Junta Sakakibara, Hiroshi Fujimoto, Takeshi Nagashima, Masayuki Ohtsuka, Ozge Ali, Most S. Parvin, Motoki Takaku, Aussie Suzuki
- Organizer
  ESMO Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08638
[Presentation] Discovery of CMPD1 as a tumor-specific cytotoxic microtubule inhibitor2023
- Author(s)
  高田　護、Aussie Suzuki, 長嶋健、藤本　浩司、榊原　淳太、山田英幸、山本　寛人、粕谷雅晴、大塚　将之
- Organizer
  日本乳癌学会
- Data Source
  KAKENHI-PROJECT-21K08638
[Presentation] Selective and Effective Targeting of Triple-Negative Breast Cancer by CMPD1: Inhibition of MAP kinase-activated protein kinase 2 and Microtubule Dynamics2023
- Author(s)
  Mamoru Takada, Yu-Chia Chen, Wang Junchiao, Hideyuki Yamada, Muhan Yu, Junta Sakakibara, Hiroshi Fujimoto, Takeshi Nagashima, Masayuki Ohtsuka, Ozge Ali, Most S. Parvin, Motoki Takaku, Aussie Suzuki
- Organizer
  SABCS
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08638
[Presentation] cancer-associated adipocyte (CAA)の特徴と癌進展に果たす役割2016
- Author(s)
  藤本浩司、藤咲薫、三階貴史、長嶋健、榊原雅裕、矢形寛、宮崎勝
- Organizer
  第24回日本乳癌学会学術総会
- Place of Presentation
  東京
- Year and Date
  2016-06-16
- Data Source
  KAKENHI-PROJECT-26461942
[Presentation] Impact of OATP2B1 expression on cell proliferation in ER-positive breast cancer.
- Author(s)
  Jun Matsumoto, Noritaka Ariyoshi, Masahiro Sakakibara, Takeo Nakanishi, Ikumi Tamai, Takeshi Nagashima and Itsuko Ishii.
- Organizer
  10th International ISSX Meeting
- Place of Presentation
  Toronto, Canada
- Data Source
  KAKENHI-PROJECT-25893224
[Presentation] Uptake of an Estrogen Precursor in Estrogen Receptor-Positive Breast Cancer Cells: Focusing on Organic Anion Transporting Polypeptide 2B1
- Author(s)
  Jun Matsumoto, Noritaka Ariyoshi, Masahiro Sakakibara, Takeo Nakanishi, Yoshiyuki Okubo, Nobumitsu Shiina, Kaoru Fujisaki, Yukio Nakatani, Ikumi Tamai, Takeshi Nagashima, Harumi Yamada, Hiroshi Takeda and Itsuko Ishii
- Organizer
  World congress on Pharmacology
- Place of Presentation
  Brisbane, Australia
- Year and Date
  2015-07-20 – 2015-07-22
- Data Source
  KAKENHI-PROJECT-25893224

1. FUJIMOTO Hiroshi (60456027)

# of Collaborated Projects: 7 results

# of Collaborated Products: 10 results
2. SAKAKIBARA Masahiro (70375632)

# of Collaborated Projects: 6 results

# of Collaborated Products: 6 results
3. MIYAZAKI Masaru (70166156)

# of Collaborated Projects: 5 results

# of Collaborated Products: 3 results
4. Sangai Takafumi (00375685)

# of Collaborated Projects: 5 results

# of Collaborated Products: 3 results
5. 大塚将之 (90334185)

# of Collaborated Projects: 4 results

# of Collaborated Products: 8 results
6. Takada Mamoru (90800392)

# of Collaborated Projects: 3 results

# of Collaborated Products: 8 results
7. 榊原淳太 (20896427)

# of Collaborated Projects: 3 results

# of Collaborated Products: 7 results
8. JUN Matsumoto (60709012)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
9. ISHII Itsuko (00202929)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
10. ARIYOSHI Noritaka (00243957)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
11. TAMAI Ikumi (20155237)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
12. NAKANISHI Takeo (30541742)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
13. 鈴木ティベリュウ浩志 (30456032)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 羽山晶子 (80758251)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 岩瀬俊明 (90738254)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 黒田正幸 (00253005)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
17. 窪田吉孝 (10375735)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
18. 山田英幸 (30925102)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 中口俊哉 (20361412)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
20. 黒田嘉宏 (30402837)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
21. Sato Mamoru

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Nagashima Takeshi 長嶋 健

NAGASHIMA Takeshi 長嶋 健

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[Journal Article] Ex vivo dual gene therapy using human adipocytes secreting anti-HER2 antibody on HER2-positive xenograft tumor models2023

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[Journal Article] A review of MRI (CT)/US fusion imaging in treatment of breast cancer2023

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[Journal Article] Less necessity of adjuvant S‐1 treatment in <scp>non‐monarchE</scp>‐eligible patients2023

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[Journal Article] Practical approach to prevent COVID-19 infection at breast cancer screening2021

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[Journal Article] Anti-HER2 antibody therapy using gene-transduced adipocytes for HER2-positive breast cancer2020

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Nagashima Takeshi 長嶋健

NAGASHIMA Takeshi 長嶋健