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Kohno Daisuke  河野 大輔

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KOHNO Daisuke  河野 大輔

河野 大輔  コウノ ダイスケ

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Researcher Number 10382904
Other IDs
External Links
Affiliation (Current) 2025: 群馬大学, 生体調節研究所, 助教
Affiliation (based on the past Project Information) *help 2018 – 2025: 群馬大学, 生体調節研究所, 助教
2013 – 2017: 群馬大学, 先端科学研究指導者育成ユニット, 助教
2006: 自治医科大学, 医学部, 研究生
Review Section/Research Field
Principal Investigator
Basic Section 59040:Nutrition science and health science-related / Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields / Environmental physiology(including physical medicine and nutritional physiology) / General physiology / Biological Sciences
Except Principal Investigator
General physiology
Keywords
Principal Investigator
視床下部 / 肥満 / DNAメチル化 / チロシン水酸化酵素 / FTO / 過食 / エピジェネティクス / エピトランスクリプトーム / エピゲノム / エピゲノム編集 … More / DNAメチル化修飾 / N6-メチルアデノシン / m6A / TET1 / DNMT3a / 摂食代謝中枢 / 弓状核 / AgRP / NPY / Dnmt3a … More
Except Principal Investigator
CRH / BDNF / NPY / leptin / ghrelin / urocortin / glucose / feeding / 室傍核 / レぷちん / Ca^<2+> / NPYニューロン / 弓状核 / レプチン / グレリン / ウロコルチン / グルコース / 摂食 Less
  • Research Projects

    (9 results)
  • Research Products

    (22 results)
  • Co-Researchers

    (8 People)
  •  視床下部のエピジェネティック修飾を起点とした肥満発症機構の解明Principal Investigator

    • Principal Investigator
      河野 大輔
    • Project Period (FY)
      2025 – 2029
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 59040:Nutrition science and health science-related
    • Research Institution
      Gunma University
  •  過食を誘導する新規神経回路の同定Principal Investigator

    • Principal Investigator
      河野 大輔
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
    • Research Institution
      Gunma University
  •  The role of epigenome and epitranscriptome in the development of obesityPrincipal Investigator

    • Principal Investigator
      河野 大輔
    • Project Period (FY)
      2021 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 59040:Nutrition science and health science-related
    • Research Institution
      Gunma University
  •  Targeting DNA methylation for the treatment of obesityPrincipal Investigator

    • Principal Investigator
      Kohno Daisuke
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
    • Research Institution
      Gunma University
  •  Role of N6-methyladenosine in the control of body weightPrincipal Investigator

    • Principal Investigator
      Kohno Daisuke
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Environmental physiology(including physical medicine and nutritional physiology)
    • Research Institution
      Gunma University
  •  DNA methylation and demethylation in the hypothalamic feeding centerPrincipal Investigator

    • Principal Investigator
      Kohno Daisuke
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      General physiology
    • Research Institution
      Gunma University
  •  視床下部弓状核ニューロンのDNAメチル化を介した摂食・代謝調節と肥満Principal Investigator

    • Principal Investigator
      河野 大輔
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      Gunma University
  •  Role of FTO in energy homeostasisPrincipal Investigator

    • Principal Investigator
      KOHNO Daisuke
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Environmental physiology(including physical medicine and nutritional physiology)
    • Research Institution
      Gunma University
  •  Inputs and outputs of NPY and BDNF neurons in the hypothalamus and their implication in feeding and metabolic regulation

    • Principal Investigator
      YADA Toshihiko
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General physiology
    • Research Institution
      Jichi Medical University

All 2024 2023 2022 2019 2018 2008 2007 2006

All Journal Article Presentation Book

  • [Book] 肥満研究:グレリン, レプチンの弓状核NPYニューロンに対する直接作用, シグナル伝達と相互作用2007

    • Author(s)
      河野 大輔
    • Publisher
      日本肥満学会
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18390065
  • [Book] 視床下部による代謝シグナルの受容と摂食調節機構.In メタボリックシンドローム-病因解明と予防・治療の最新戦略-2006

    • Author(s)
      河野大輔
    • Publisher
      日本臨床 第64巻 増刊号9
    • Data Source
      KAKENHI-PROJECT-18390065
  • [Book] 日本臨床増刊号:視床下部による代謝シグナルの受容と摂食調節機構.Inメタボリックシンドローム-病因解明と予防、治療の最新戦略2006

    • Author(s)
      河野 大輔
    • Publisher
      日本臨床64(9)
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18390065
  • [Journal Article] DNA Methylation in the Hypothalamic Feeding Center and Obesity2023

    • Author(s)
      Yoshikawa Chiharu、Ariyani Winda、Kohno Daisuke
    • Journal Title

      Journal of Obesity &amp; Metabolic Syndrome

      Volume: 32 Issue: 4 Pages: 303-311

    • DOI

      10.7570/jomes23073

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23K21617
  • [Journal Article] Ghrelin raises [Ca^<2+>]i via AMPK in hypothalamic arcuate nucleus NPY neurons2008

    • Author(s)
      Kohno D
    • Journal Title

      Biochem Biophys Res Commun 366

      Pages: 388-392

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390065
  • [Journal Article] Ghrelin raises [Ca^<2+>] via AMPK in hypothalamic arcuate nucleus NPY neurons.2008

    • Author(s)
      Kohno, D
    • Journal Title

      Biochem Biophys Res Commun 366

      Pages: 388-392

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390065
  • [Journal Article] Nesfatin-1 neurons in paraventricular and supraoptic nuclei of the rat hypothalamus coexpress oxytocin and vasopressin and are activated by refeeding.2008

    • Author(s)
      Kohno, D
    • Journal Title

      Endocrinology 149

      Pages: 1295-1301

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390065
  • [Journal Article] Nesfatin-1 neurons in paraventricular and supraoptic nuclei of the rat hypothalamus coexpress oxytocin and vasopressin and are activated by refeeding2008

    • Author(s)
      Kohno D
    • Journal Title

      Endocrinology 149

      Pages: 1295-1301

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390065
  • [Journal Article] Nesfatin-1 neurons in paraventricular and supraoptic nuclei of the rat hypothalam us coexpress oxytocin and vasopressin and are activated by refeeding.2008

    • Author(s)
      Kohno D
    • Journal Title

      Endocrinology 149

      Pages: 1295-1301

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390065
  • [Journal Article] Leptin suppresses ghrelin-induced activation of neuropeptide Y neurons in the arcuate nucleus via phosphatidylinositol 3-kinase- and phosphodiesterase 3-mediated pathway2007

    • Author(s)
      Kohno D
    • Journal Title

      Endocrinology 148

      Pages: 2251-2263

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390065
  • [Journal Article] Leptin suppresses ghrelin-induced activation of neuropeptide Y neurons in the arcuate nucleus via phosphatidylinositol 3-kinase- and phosphodiesterase 3-mediated pathway.2007

    • Author(s)
      Kohno, D
    • Journal Title

      Endocrinology 148

      Pages: 2251-2263

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390065
  • [Journal Article] Direct effects, signaling and interaction of ghrelin and leptin in NPY neurons of arcuate nucleus2007

    • Author(s)
      Kohno, D
    • Journal Title

      Obesity Research

      Pages: 215-219

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390065
  • [Journal Article] Hypothalamic nuclei sense metabolic signals and regulate feeding.2006

    • Author(s)
      Kohno, D
    • Journal Title

      Nippon Rinsho

      Pages: 91-97

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390065
  • [Presentation] AgRPニューロンのFTOによるm6A修飾の脱メチル化を介した体重調節機構2024

    • Author(s)
      河野大輔
    • Organizer
      第101回日本生理学会大会
    • Data Source
      KAKENHI-PROJECT-23K21617
  • [Presentation] AgRP ニューロンの FTO による体重制御機構2023

    • Author(s)
      河野大輔、川端麗香、須山成朝、大橋一登、Winda Ariyani、橋本博美、吉川千遥、松居翔、矢田俊彦、佐々木努、北村忠弘
    • Organizer
      第44回日本肥満学会
    • Data Source
      KAKENHI-PROJECT-23K21617
  • [Presentation] 視床下部室傍核ドーパミンニューロンの摂食行動における役割2022

    • Author(s)
      河野 大輔、アリヤニウィンダ、常岡 明加、吉川 千遥、一瀬 宏、北村 忠弘
    • Organizer
      第43回日本肥満学会
    • Data Source
      KAKENHI-PROJECT-23K21617
  • [Presentation] 視床下部のFTOによる体重調節機2019

    • Author(s)
      河野 大輔、川端 麗香、西山 正彦、佐々木 努、北村 忠弘
    • Organizer
      第40回日本肥満学会
    • Data Source
      KAKENHI-PROJECT-17K08566
  • [Presentation] 視床下部のFTOによるm6A修飾を介した体重調節機構2018

    • Author(s)
      河野 大輔
    • Organizer
      第39回日本肥満学会
    • Data Source
      KAKENHI-PROJECT-17K08566
  • [Presentation] FTOによるm6A修飾の制御と体重調節2018

    • Author(s)
      河野大輔
    • Organizer
      第12回日本エピジェネティクス研究会年会
    • Data Source
      KAKENHI-PROJECT-17K08566
  • [Presentation] 視床下部におけるFTOとm6A修飾の役割2018

    • Author(s)
      河野 大輔
    • Organizer
      第7回日本DOHaD学会学術集会
    • Data Source
      KAKENHI-PROJECT-17K08566
  • [Presentation] Ghrelin and leptin reciprocally regulate NPY neurons in the arcuate nucleus2006

    • Author(s)
      Kohno, D
    • Organizer
      The 16th International Symposium on Regulatory Peptides(REGPEP 06)
    • Place of Presentation
      Hakone, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390065
  • [Presentation] Ghrelin and leptin reciprocally regulate NPY neurons in the arcuate nucleus2006

    • Author(s)
      Kohno D
    • Organizer
      The 16th Intemational Symposium on Regulatory Peptides (REGPEP 06)
    • Place of Presentation
      Hakone,Japan
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18390065
  • 1.  YADA Toshihiko (60166527)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 2.  NAKATA Masanori (10305120)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  DEZAKI Katsuya (90337329)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  FUJIWARA Ken (00382945)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  TORIYA Masako (90420819)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  MAEJIMA Yuko (40438669)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  畑田 出穂 (50212147)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  川端 麗香 (90721928)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results

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