Kohno Daisuke 河野大輔

… Alternative Names

KOHNO Daisuke 河野大輔

河野大輔コウノダイスケ

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Researcher Number	10382904
Other IDs
External Links
Affiliation (Current)	2025: 群馬大学, 生体調節研究所, 助教
Affiliation (based on the past Project Information) *help	2018 – 2025: 群馬大学, 生体調節研究所, 助教 2013 – 2017: 群馬大学, 先端科学研究指導者育成ユニット, 助教 2006: 自治医科大学, 医学部, 研究生
Review Section/Research Field	Principal Investigator Basic Section 59040:Nutrition science and health science-related / Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields / Environmental physiology(including physical medicine and nutritional physiology) / General physiology / Biological Sciences Except Principal Investigator General physiology
Keywords	Principal Investigator 視床下部 / 肥満 / DNAメチル化 / チロシン水酸化酵素 / FTO / 過食 / エピジェネティクス / エピトランスクリプトーム / エピゲノム / エピゲノム編集 … More / DNAメチル化修飾 / N6-メチルアデノシン / m6A / TET1 / DNMT3a / 摂食代謝中枢 / 弓状核 / AgRP / NPY / Dnmt3a … More Except Principal Investigator CRH / BDNF / NPY / leptin / ghrelin / urocortin / glucose / feeding / 室傍核 / レぷちん / Ca^<2+> / NPYニューロン / 弓状核 / レプチン / グレリン / ウロコルチン / グルコース / 摂食 Less

視床下部のエピジェネティック修飾を起点とした肥満発症機構の解明Principal Investigator
- Principal Investigator
  
  河野大輔
- Project Period (FY)
  2025 – 2029
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Gunma University
過食を誘導する新規神経回路の同定Principal Investigator
- Principal Investigator
  
  河野大輔
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
- Research Institution
  Gunma University
The role of epigenome and epitranscriptome in the development of obesityPrincipal Investigator
- Principal Investigator
  
  河野大輔
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Gunma University
Targeting DNA methylation for the treatment of obesityPrincipal Investigator
- Principal Investigator
  
  Kohno Daisuke
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
- Research Institution
  Gunma University
Role of N6-methyladenosine in the control of body weightPrincipal Investigator
- Principal Investigator
  
  Kohno Daisuke
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Environmental physiology(including physical medicine and nutritional physiology)
- Research Institution
  Gunma University
DNA methylation and demethylation in the hypothalamic feeding centerPrincipal Investigator
- Principal Investigator
  
  Kohno Daisuke
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General physiology
- Research Institution
  Gunma University
視床下部弓状核ニューロンのDNAメチル化を介した摂食・代謝調節と肥満Principal Investigator
- Principal Investigator
  
  河野大輔
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Gunma University
Role of FTO in energy homeostasisPrincipal Investigator
- Principal Investigator
  
  KOHNO Daisuke
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Environmental physiology(including physical medicine and nutritional physiology)
- Research Institution
  Gunma University
Inputs and outputs of NPY and BDNF neurons in the hypothalamus and their implication in feeding and metabolic regulation
- Principal Investigator
  
  YADA Toshihiko
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General physiology
- Research Institution
  Jichi Medical University

All 2024 2023 2022 2019 2018 2008 2007 2006

All Journal Article Presentation Book

[Book] 肥満研究:グレリン, レプチンの弓状核NPYニューロンに対する直接作用, シグナル伝達と相互作用2007
- Author(s)
  河野大輔
- Publisher
  日本肥満学会
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18390065
[Book] 視床下部による代謝シグナルの受容と摂食調節機構.In メタボリックシンドローム-病因解明と予防・治療の最新戦略-2006
- Author(s)
  河野大輔
- Publisher
  日本臨床第64巻増刊号9
- Data Source
  KAKENHI-PROJECT-18390065
[Book] 日本臨床増刊号:視床下部による代謝シグナルの受容と摂食調節機構.Inメタボリックシンドローム-病因解明と予防、治療の最新戦略2006
- Author(s)
  河野大輔
- Publisher
  日本臨床64(9)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18390065
[Journal Article] DNA Methylation in the Hypothalamic Feeding Center and Obesity2023
- Author(s)
  Yoshikawa Chiharu、Ariyani Winda、Kohno Daisuke
- Journal Title
  
  Journal of Obesity & Metabolic Syndrome
  
  Volume: 32 Issue: 4 Pages: 303-311
- DOI
  10.7570/jomes23073
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K21617
[Journal Article] Ghrelin raises [Ca^<2+>]i via AMPK in hypothalamic arcuate nucleus NPY neurons2008
- Author(s)
  Kohno D
- Journal Title
  
  Biochem Biophys Res Commun 366
  
  Pages: 388-392
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390065
[Journal Article] Ghrelin raises [Ca^<2+>] via AMPK in hypothalamic arcuate nucleus NPY neurons.2008
- Author(s)
  Kohno, D
- Journal Title
  
  Biochem Biophys Res Commun 366
  
  Pages: 388-392
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390065
[Journal Article] Nesfatin-1 neurons in paraventricular and supraoptic nuclei of the rat hypothalamus coexpress oxytocin and vasopressin and are activated by refeeding.2008
- Author(s)
  Kohno, D
- Journal Title
  
  Endocrinology 149
  
  Pages: 1295-1301
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390065
[Journal Article] Nesfatin-1 neurons in paraventricular and supraoptic nuclei of the rat hypothalamus coexpress oxytocin and vasopressin and are activated by refeeding2008
- Author(s)
  Kohno D
- Journal Title
  
  Endocrinology 149
  
  Pages: 1295-1301
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390065
[Journal Article] Nesfatin-1 neurons in paraventricular and supraoptic nuclei of the rat hypothalam us coexpress oxytocin and vasopressin and are activated by refeeding.2008
- Author(s)
  Kohno D
- Journal Title
  
  Endocrinology 149
  
  Pages: 1295-1301
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390065
[Journal Article] Leptin suppresses ghrelin-induced activation of neuropeptide Y neurons in the arcuate nucleus via phosphatidylinositol 3-kinase- and phosphodiesterase 3-mediated pathway2007
- Author(s)
  Kohno D
- Journal Title
  
  Endocrinology 148
  
  Pages: 2251-2263
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390065
[Journal Article] Leptin suppresses ghrelin-induced activation of neuropeptide Y neurons in the arcuate nucleus via phosphatidylinositol 3-kinase- and phosphodiesterase 3-mediated pathway.2007
- Author(s)
  Kohno, D
- Journal Title
  
  Endocrinology 148
  
  Pages: 2251-2263
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390065
[Journal Article] Direct effects, signaling and interaction of ghrelin and leptin in NPY neurons of arcuate nucleus2007
- Author(s)
  Kohno, D
- Journal Title
  
  Obesity Research
  
  Pages: 215-219
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390065
[Journal Article] Hypothalamic nuclei sense metabolic signals and regulate feeding.2006
- Author(s)
  Kohno, D
- Journal Title
  
  Nippon Rinsho
  
  Pages: 91-97
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390065
[Presentation] AgRPニューロンのFTOによるm6A修飾の脱メチル化を介した体重調節機構2024
- Author(s)
  河野大輔
- Organizer
  第101回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-23K21617
[Presentation] AgRP ニューロンの FTO による体重制御機構2023
- Author(s)
  河野大輔、川端麗香、須山成朝、大橋一登、Winda Ariyani、橋本博美、吉川千遥、松居翔、矢田俊彦、佐々木努、北村忠弘
- Organizer
  第44回日本肥満学会
- Data Source
  KAKENHI-PROJECT-23K21617
[Presentation] 視床下部室傍核ドーパミンニューロンの摂食行動における役割2022
- Author(s)
  河野大輔、アリヤニウィンダ、常岡明加、吉川千遥、一瀬宏、北村忠弘
- Organizer
  第43回日本肥満学会
- Data Source
  KAKENHI-PROJECT-23K21617
[Presentation] 視床下部のFTOによる体重調節機2019
- Author(s)
  河野大輔、川端麗香、西山正彦、佐々木努、北村忠弘
- Organizer
  第40回日本肥満学会
- Data Source
  KAKENHI-PROJECT-17K08566
[Presentation] 視床下部のFTOによるm6A修飾を介した体重調節機構2018
- Author(s)
  河野大輔
- Organizer
  第39回日本肥満学会
- Data Source
  KAKENHI-PROJECT-17K08566
[Presentation] FTOによるm6A修飾の制御と体重調節2018
- Author(s)
  河野大輔
- Organizer
  第12回日本エピジェネティクス研究会年会
- Data Source
  KAKENHI-PROJECT-17K08566
[Presentation] 視床下部におけるFTOとm6A修飾の役割2018
- Author(s)
  河野大輔
- Organizer
  第7回日本DOHaD学会学術集会
- Data Source
  KAKENHI-PROJECT-17K08566
[Presentation] Ghrelin and leptin reciprocally regulate NPY neurons in the arcuate nucleus2006
- Author(s)
  Kohno, D
- Organizer
  The 16th International Symposium on Regulatory Peptides(REGPEP 06)
- Place of Presentation
  Hakone, Japan
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390065
[Presentation] Ghrelin and leptin reciprocally regulate NPY neurons in the arcuate nucleus2006
- Author(s)
  Kohno D
- Organizer
  The 16th Intemational Symposium on Regulatory Peptides (REGPEP 06)
- Place of Presentation
  Hakone,Japan
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18390065

1. YADA Toshihiko (60166527)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. NAKATA Masanori (10305120)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. DEZAKI Katsuya (90337329)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. FUJIWARA Ken (00382945)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. TORIYA Masako (90420819)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. MAEJIMA Yuko (40438669)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 畑田出穂 (50212147)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 川端麗香 (90721928)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results

Kohno Daisuke 河野 大輔

KOHNO Daisuke 河野 大輔

河野 大輔 コウノ ダイスケ

Research Projects

Research Products

Co-Researchers

視床下部のエピジェネティック修飾を起点とした肥満発症機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

過食を誘導する新規神経回路の同定Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The role of epigenome and epitranscriptome in the development of obesityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Targeting DNA methylation for the treatment of obesityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Role of N6-methyladenosine in the control of body weightPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

DNA methylation and demethylation in the hypothalamic feeding centerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

視床下部弓状核ニューロンのDNAメチル化を介した摂食・代謝調節と肥満Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Role of FTO in energy homeostasisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Inputs and outputs of NPY and BDNF neurons in the hypothalamus and their implication in feeding and metabolic regulation

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 肥満研究:グレリン, レプチンの弓状核NPYニューロンに対する直接作用, シグナル伝達と相互作用2007

Author(s)

Publisher

Description

Data Source

[Book] 視床下部による代謝シグナルの受容と摂食調節機構.In メタボリックシンドローム-病因解明と予防・治療の最新戦略-2006

Author(s)

Publisher

Data Source

[Book] 日本臨床増刊号:視床下部による代謝シグナルの受容と摂食調節機構.Inメタボリックシンドローム-病因解明と予防、治療の最新戦略2006

Author(s)

Publisher

Description

Data Source

[Journal Article] DNA Methylation in the Hypothalamic Feeding Center and Obesity2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Ghrelin raises [Ca^<2+>]i via AMPK in hypothalamic arcuate nucleus NPY neurons2008

Kohno Daisuke 河野大輔

KOHNO Daisuke 河野大輔

河野大輔コウノダイスケ