Ito Genta 伊藤弦太

… Alternative Names

ITO Genta 伊藤弦太

伊藤弦太イトウゲンタ

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Researcher Number	10431892
Other IDs	https://orcid.org/0000-0001-6370-1099
Affiliation (Current)	2024: 帝京大学, 薬学部, 講師
Affiliation (based on the past Project Information) *help	2021 – 2023: 帝京大学, 薬学部, 講師 2018 – 2022: 東京大学, 大学院薬学系研究科(薬学部), 特任講師 2017: 東京大学, 大学院薬学系研究科, 特任講師 2014: 東京大学, 大学院医学系研究科, 助教 2013: 東京大学, 医学(系)研究科(研究員), 助教 … More 2012 – 2013: 東京大学, 医学(系)研究科(研究院), 助教 2010 – 2011: 東京大学, 大学院・医学系研究科, 助教 2007: The University of Tokyo, 大学院・薬学系研究科, 助教 2006: 東京大学, 大学院薬学系研究科, 助手 Less
Review Section/Research Field	Principal Investigator Biological pharmacy / Basic Section 47030:Pharmaceutical hygiene and biochemistry-related Except Principal Investigator Medium-sized Section 47:Pharmaceutical sciences and related fields / Biological Sciences
Keywords	Principal Investigator パーキンソン病 / LRRK2 / キナーゼ / 小胞輸送 / リン酸化 / リソソーム / Rab / ＬＲＲＫ２ / TurboID / ゲラニルゲラニル化 … More / Rab29 / Rab12 / Ｒａｂ / GTPase / 細胞内局在 / GTP結合蛋白質 / GTP結合タンパク質 … More Except Principal Investigator ストレス応答 / グリア細胞 / 神経変性 / 認知症 / マイクロダイアリシス / βアミロイド / アルツハイマー / 神経活動 / アミロイド / 光遺伝学 / シナプス / アミロイドβペプチド / アルツハイマー病 Less

パーキンソン病発症におけるLRRK2異常活性化メカニズムとその病的意義の解明Principal Investigator
- Principal Investigator
  
  伊藤弦太
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Teikyo University
Elucidation of Cellular Pathogenesis as a Key Mechanism for Neurodegenerative Processes in the Pathogenesis of Dementia
- Principal Investigator
  
  Tomita Taisuke
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  The University of Tokyo
Elucidation of the molecular pathogenesis of Parkinson disease by uncovering the LRRK2-Rab pathwayPrincipal Investigator
- Principal Investigator
  
  Ito Genta
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  The University of Tokyo
Membrane localization of LRRK2, a causative gene for familial Parkinson'sPrincipal Investigator
- Principal Investigator
  
  ITO Genta
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  The University of Tokyo
Elucidation of the molecular pathology of Alzheimer's disease focusing on the synapses toward therapies
- Principal Investigator
  
  IWATSUBO Takeshi
- Project Period (FY)
  2010 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Characterization of pathophysiological substrates of LRRK2, a causative gene product for familial Parkinson's diseasePrincipal Investigator
- Principal Investigator
  
  ITO Genta
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  The University of Tokyo
家族性パーキンソン病責任遺伝子産物LRRK2の機能解析Principal Investigator
- Principal Investigator
  
  伊藤弦太
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (Start-up)
- Research Field
  
  Biological pharmacy
- Research Institution
  The University of Tokyo

All 2023 2022 2021 2020 2019 2018 2017 2015 2012 2011 2010 2007

All Journal Article Presentation Patent

[Journal Article] LRRK2-mediated phosphorylation and thermal stability of Rab12 areregulated by bound nucleotides2023
- Author(s)
  Genta Ito, Taisuke Tomita and Naoko Utsunomiya-Tate
- Journal Title
  
  Biochem.Biophys.Res. Commun.
  
  Volume: 667 Pages: 43-49
- DOI
  10.1016/j.bbrc.2023.05.048
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06498, KAKENHI-PROJECT-21K06558, KAKENHI-PROJECT-23H00394
[Journal Article] Pathogenic <scp>LRRK2</scp> compromises the subcellular distribution of lysosomes in a <scp>Rab12‐RILPL1</scp> ‐dependent manner2023
- Author(s)
  Ito Kyohei、Araki Miho、Katai Yuta、Nishimura Yuki、Imotani Sota、Inoue Haruki、Ito Genta、Tomita Taisuke
- Journal Title
  
  The FASEB Journal
  
  Volume: 37 Issue: 5
- DOI
  10.1096/fj.202200780rr
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H01015, KAKENHI-PROJECT-21K06558, KAKENHI-PROJECT-23KJ0613, KAKENHI-PROJECT-23H00394
[Journal Article] Site-specific amino acid D-isomerization of Tau R2 and R3 peptides changes the fibril morphology, resulting in attenuation of Tau aggregation inhibitor potency.2023
- Author(s)
  Murata T., Ito, G. and Utsunomiya-Tate, N.
- Journal Title
  
  Biochem. Biophys, Res. Commun.
  
  Volume: 654 Pages: 18-25
- DOI
  10.1016/j.bbrc.2023.02.073
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06498, KAKENHI-PROJECT-21K06558
[Journal Article] INPP5D modulates TREM2 loss-of-function phenotypes in a β-amyloidosis mouse model2023
- Author(s)
  Iguchi Akihiro、Takatori Sho、Kimura Shingo、Muneto Hiroki、Wang Kai、Etani Hayato、Ito Genta、Sato Haruaki、Hori Yukiko、Sasaki Junko、Saito Takashi、Saido Takaomi C.、Ikezu Tsuneya、Takai Toshiyuki、Sasaki Takehiko、Tomita Taisuke
- Journal Title
  
  iScience
  
  Volume: 26 Issue: 4 Pages: 106375-106375
- DOI
  10.1016/j.isci.2023.106375
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06558, KAKENHI-PROJECT-22K07344, KAKENHI-PROJECT-19H01015, KAKENHI-PROJECT-21H02680, KAKENHI-PROJECT-21J13397, KAKENHI-PROJECT-22KJ0968, KAKENHI-ORGANIZER-22H05035, KAKENHI-PLANNED-22H05036, KAKENHI-PROJECT-23H00394, KAKENHI-PROJECT-23K27319
[Journal Article] ADAMTS4 is involved in the production of the Alzheimer disease amyloid biomarker APP669-7112023
- Author(s)
  Matsuzaki Masaya、Yokoyama Miyabishara、Yoshizawa Yota、Kaneko Naoki、Naito Hiroki、Kobayashi Honoka、Korenaga Akihito、Sekiya Sadanori、Ikemura Kentaro、Opoku Gabriel、Hirohata Satoshi、Iwamoto Shinichi、Tanaka Koichi、Tomita Taisuke
- Journal Title
  
  Molecular Psychiatry
  
  Volume: - Issue: 4 Pages: 1-11
- DOI
  10.1038/s41380-023-01946-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H01015, KAKENHI-PROJECT-22J14778, KAKENHI-PROJECT-20H00548, KAKENHI-PROJECT-23H00394
[Journal Article] Overview of the Impact of Pathogenic LKKR2 Mutation Parkinson's Disease2023
- Author(s)
  Ito.G. and Utsunomiya-Tate N.
- Journal Title
  
  Biomolecules
  
  Volume: 13 Issue: 5 Pages: 845-845
- DOI
  10.3390/biom13050845
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06498, KAKENHI-PROJECT-21K06558
[Journal Article] Lipid flippase dysfunction as a therapeutic target for endosomal anomalies in Alzheimer’s disease2022
- Author(s)
  Kaneshiro Nanaka、Komai Masato、Imaoka Ryosuke、Ikeda Atsuya、Kamikubo Yuji、Saito Takashi、Saido Takaomi C.、Tomita Taisuke、Hashimoto Tadafumi、Iwatsubo Takeshi、Sakurai Takashi、Uehara Takashi、Takasugi Nobumasa
- Journal Title
  
  iScience
  
  Volume: 25 Issue: 3 Pages: 103869-103869
- DOI
  10.1016/j.isci.2022.103869
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H01015, KAKENHI-PROJECT-21H02815, KAKENHI-PROJECT-19J22442, KAKENHI-PROJECT-20K07014, KAKENHI-PROJECT-20K07765, KAKENHI-PROJECT-21K07270
[Journal Article] The atypical Rab GTPase associated with Parkinson’s disease, Rab29, is localized to membranes2022
- Author(s)
  Nagai-Ito Yuki、Xu Lejia、Ito Kyohei、Kajihara Yotaro、Ito Genta、Tomita Taisuke
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 298 Issue: 10 Pages: 102499-102499
- DOI
  10.1016/j.jbc.2022.102499
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06558, KAKENHI-PROJECT-19H01015
[Journal Article] BORCS6 is involved in the enlargement of lung lamellar bodies in Lrrk2 knockout mice2021
- Author(s)
  Miho Araki, Kyohei Ito, Sho Takatori, Genta Ito, Taisuke Tomita
- Journal Title
  
  Human Molecular Genetics
  
  Volume: 30(17) Issue: 17 Pages: 1618-1631
- DOI
  10.1093/hmg/ddab146
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07080, KAKENHI-PROJECT-19H01015, KAKENHI-PROJECT-21K06558
[Journal Article] The Regulation of Rab GTPases by Phosphorylation2021
- Author(s)
  Xu Lejia、Nagai Yuki、Kajihara Yotaro、Ito Genta、Tomita Taisuke
- Journal Title
  
  Biomolecules
  
  Volume: 11 Issue: 9 Pages: 1340-1340
- DOI
  10.3390/biom11091340
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H01015, KAKENHI-PROJECT-21K06558
[Journal Article] Detection of Substrate Phosphorylation of in Tissues and Cultured Cells2021
- Author(s)
  Ito Kyohei、Xu Lejia、Ito Genta、Tomita Taisuke
- Journal Title
  
  Methods Mol Biol
  
  Volume: 1 Pages: 53-61
- DOI
  10.1007/978-1-0716-1495-2_6
- ISBN
  9781071614945, 9781071614952
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H01015, KAKENHI-PROJECT-21K06558
[Journal Article] Suppression of amyloid‐β secretion from neurons by cis‐9,trans‐11‐octadecadienoic acid, an isomer of conjugated linoleic acid2021
- Author(s)
  Hata Saori、Kano Kuniyuki、Kikuchi Kazunori、Kinoshita Shoichi、Sobu Yuriko、Saito Haruka、Saito Takashi、Saido Takaomi C.、Sano Yoshitake、Taru Hidenori、Aoki Junken、Komano Hiroto、Tomita Taisuke、Natori Shunji、Suzuki Toshiharu
- Journal Title
  
  Journal of Neurochemistry
  
  Volume: 159 Issue: 3 Pages: 603-617
- DOI
  10.1111/jnc.15490
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H01015
[Journal Article] Human tauopathy-derived tau strains determine the substrates recruited for templated amplification2021
- Author(s)
  Tarutani Airi、Miyata Haruka、Nonaka Takashi、Hasegawa Kazuko、Yoshida Mari、Saito Yuko、Murayama Shigeo、Robinson Andrew C、Mann David M A、Tomita Taisuke、Hasegawa Masato
- Journal Title
  
  Brain
  
  Volume: - Issue: 8 Pages: 2333-2348
- DOI
  10.1093/brain/awab091
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16482, KAKENHI-PROJECT-19H01015, KAKENHI-PROJECT-16H06277
[Journal Article] Physiological and pathological functions of LRRK2: implications from substrate proteins2018
- Author(s)
  Araki Miho、Ito Genta、Tomita Taisuke
- Journal Title
  
  Neuronal Signaling
  
  Volume: 2 Issue: 4
- DOI
  10.1042/ns20180005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08265, KAKENHI-PROJECT-15H02492
[Journal Article] Interrogating Parkinson's disease LRRK2 kinase pathway activity by assessing Rab10 phosphorylation in human neutrophils2018
- Author(s)
  Ying Fan, Andrew J.M. Howden, Adil R. Sarhan, Pawel Lis, Genta Ito, Terina N. Martinez, Kathrin Brockmann, Thomas Gasser, Dario R. Alessi, Esther M. Sammler
- Journal Title
  
  Biochemical Journal
  
  Volume: 475 Issue: 1 Pages: 23-44
- DOI
  10.1042/bcj20170803
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08265
[Journal Article] LRRK2 and its substrate Rab GTPases are sequentially targeted onto stressed lysosomes and maintain their homeostasis2018
- Author(s)
  Eguchi Tomoya、Kuwahara Tomoki、Sakurai Maria、Komori Tadayuki、Fujimoto Tetta、Ito Genta、Yoshimura Shin-ichiro、Harada Akihiro、Fukuda Mitsunori、Koike Masato、Iwatsubo Takeshi
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 115 Issue: 39
- DOI
  10.1073/pnas.1812196115
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08265, KAKENHI-PROJECT-17K08522, KAKENHI-PUBLICLY-17H05682, KAKENHI-PLANNED-17H06422, KAKENHI-PROJECT-18H02594, KAKENHI-PROJECT-16K07039, KAKENHI-PROJECT-16H06280
[Journal Article] Rab10 Phosphorylation Detection by LRRK2 Activity Using SDS-PAGE with a Phosphate-binding Tag2017
- Author(s)
  Genta Ito, Taisuke Tomita
- Journal Title
  
  Journal of Visualized Experiments
  
  Volume: － Issue: 130
- DOI
  10.3791/56688
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08265, KAKENHI-PROJECT-15H02492
[Journal Article] Chronic optogenetic activation augments Aβ pathology in a mouse model of Alzheimer disease2015
- Author(s)
  Kaoru Yamamoto, Zen-ichi Tanei, Tadafumi Hashimoto, Tomoko Wakabayashi, Hiroyuki Okuno, Yasushi Naka, Ofer Yizhar, Lief E. Fenno, Masashi Fukayama, Haruhiko Bito, John R. Cirrito, David M. Holtzman, Karl Deisseroth, Takeshi Iwatsubo
- Journal Title
  
  Cell reports
  
  Volume: 11 Issue: 6 Pages: 859-865
- DOI
  10.1016/j.celrep.2015.04.017
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-22110003, KAKENHI-PROJECT-221S0003, KAKENHI-PROJECT-15K08297, KAKENHI-PROJECT-15H02358
[Journal Article] Re-examination of the dimerization state of leucine-rich repeat kinase 2 : predominance of the monomeric form2012
- Author(s)
  Ito G, Iwatsubo T.
- Journal Title
  
  Biochemical Journal
  
  Volume: 441巻 Issue: 3 Pages: 987-994
- DOI
  10.1042/bj20111215
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790058, KAKENHI-PROJECT-24790068
[Journal Article] Phosphorylation of α-synuclein protein at Ser-129 reduces neuronal dysfunction by lowering its membrane binding property in Caenorhabditis elegans2012
- Author(s)
  Kuwahara T, Tonegawa R, Ito G, Mitani S, Iwatsubo T
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 287 Issue: 10 Pages: 7098-7109
- DOI
  10.1074/jbc.m111.237131
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22110003, KAKENHI-PROJECT-22790058, KAKENHI-PROJECT-24790068
[Journal Article] GTP binding is essential to the protein kinase activity of LRRK2, a causative gene product for familial Parkinson's disease2007
- Author(s)
  Genta Ito
- Journal Title
  
  Biochemistry 46(5)
  
  Pages: 1380-1388
- Data Source
  KAKENHI-PROJECT-18890053
[Patent] 自閉症発症機構に関連する接着分子2019
- Inventor(s)
  富田泰輔、伊藤弦太、高鳥翔、長友亮太、吉田文明
- Industrial Property Rights Holder
  富田泰輔、伊藤弦太、高鳥翔、長友亮太、吉田文明
- Industrial Property Rights Type
  特許
- Filing Date
  2019
- Overseas
- Data Source
  KAKENHI-PROJECT-17K08265
[Presentation] Regulation of intracellular lysosomal positioning by LRRK22023
- Author(s)
  Kyohei Ito, Miho Araki, Yuta Katai, Yuki Nishimura, Sota Imotani, Haruki Inoue, Genta Ito, Taisuke Tomita
- Organizer
  Neuroscience 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06558
[Presentation] パーキンソン病関連タンパク質Rab3Aの二次構造と熱安定性の解析2023
- Author(s)
  伊藤弦太、富田泰輔、楯直子
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-21K06558
[Presentation] パーキンソン病関連タンパク質Rab12の二次構造とLRRK2によるリン酸化に関する解析2023
- Author(s)
  伊藤弦太、中村亮、楯直子
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-21K06558
[Presentation] Comprehensive identification of proximal proteins and functional analysis of Rab292023
- Author(s)
  Lejia Xu, Genta Ito, Taisuke Tomita
- Organizer
  Neuroscience 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06558
[Presentation] パーキンソン病原因キナーゼLRRK2によるリソソーム局在制御機構の解明2023
- Author(s)
  伊藤弦太、伊藤恭平、荒木美保、片井悠太、西村佑紀、芋谷颯太、井上晴幾、楯直子、富田泰輔
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K06558
[Presentation] Rab12のヌクレオチド結合状態がLRRK2によるリン酸化と二次構造に与える影響2023
- Author(s)
  伊藤弦太、富田泰輔、楯直子
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21K06558
[Presentation] パーキンソン病リスク遺伝子Rab29近傍タンパク質の網羅的同定と機能解析2022
- Author(s)
  徐楽佳、伊藤弦太、富田泰輔
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21K06558
[Presentation] プロテアーゼを利用したRab29ヌクレオチド結合状態解析系の確立2022
- Author(s)
  梶原陽太郎、伊藤弦太、富田泰輔
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] パーキンソン病リスク遺伝子Rab29近傍タンパク質の網羅的同定と機能解析2022
- Author(s)
  徐楽佳、伊藤弦太、富田泰輔
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] ADAMTS4 as an enzyme cleaving at APP669 site.2022
- Author(s)
  Naoki Kaneko, Miyabishara Yokoyama, Masaya Matsuzaki, Kentaro Ikemura, Gabriel Opoku, Akihito Korenaga, Sadanori Sekiya, Shinichi Iwamoto, Satoshi Hirohata, Koichi Tanaka, Taisuke Tomita
- Organizer
  AAIC2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] プロテアーゼを利用したRab29ヌクレオチド結合状態解析系の確立2022
- Author(s)
  梶原陽太郎、伊藤弦太、富田泰輔
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21K06558
[Presentation] Pathological roles of microglial gene INPP5D in a mouse model of Alzheimer disease.2022
- Author(s)
  Sho Takatori, Akihiro Iguchi, Shingo Kimura, Hiroki Muneto, Kai Wang, Hayato Etani, Yukiko Hori, Junko Sasaki, Takashi Saito, Takaomi C Saido, Tsuneya Ikezu, Toshiyuki Takai, Takehiko Sasaki, Taisuke Tomita
- Organizer
  ISMND2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] パーキンソン病原因遺伝子LRRK2が引き起こすリソソーム局在変化2022
- Author(s)
  伊藤恭平、荒木美保、片井悠太、西村佑紀、井上晴幾、伊藤弦太、富田泰輔
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] Analysis of the secondary structure of Rab12, a protein implicated in the pathogenesis of Parkinson’s disease2022
- Author(s)
  伊藤弦太、中村亮、楯直子
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21K06558
[Presentation] INPP5D modulates TREM2 loss-of-function phenotypes in a mouse model of Alzheimer disease.2022
- Author(s)
  Akihiro Iguchi, Sho Takatori, Shingo Kimura, Yukiko Hori, Junko Sasaki, Takashi Saito, Takaomi C Saido, Tsuneya Ikezu, Toshiyuki Takai, Takehiko Sasaki, Taisuke Tomita
- Organizer
  CINF2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] LRRK2によるリソソームの細胞内局在制御2022
- Author(s)
  伊藤弦太、伊藤恭平、片井悠太、西村佑紀、井上晴幾、富田泰輔
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] パーキンソン病原因遺伝子LRRK2が引き起こすリソソーム局在変化2022
- Author(s)
  伊藤恭平、荒木美保、片井悠太、西村佑紀、井上晴幾、伊藤弦太、富田泰輔
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21K06558
[Presentation] LRRK2によるリソソームの細胞内局在制御2021
- Author(s)
  伊藤弦太、伊藤恭平、荒木美保、片井悠太、西村佑紀、井上晴幾、富田泰輔
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-21K06558
[Presentation] INPP5D haplodeficiency rescued TREM2-loss-of-function phenotype of microglia in Alzheimer disease model mice.2021
- Author(s)
  Akihiro Iguchi, Sho Takatori, Shingo Kimura, Yukiko Hori, Junko Sasaki, Takashi Saito, Sakaomi C. Saido, Tsuneya Ikezu, Toshiyuki Takai, Takehiko Sasaki, Taisuke Tomita
- Organizer
  New Horizons in Alzheimer's Disease (Hybrid edition)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] 自閉症モデルマウスにおけるシナプス形成異常関連分子Lingo2の代謝機構解析2021
- Author(s)
  熊詩若、吉田文明、伊藤弦太、高鳥翔、富田泰輔
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] LRRK2によるリソソーム局在化制御と生物学的意義2021
- Author(s)
  伊藤弦太
- Organizer
  第40回日本認知症学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-21K06558
[Presentation] ADAMTS4 cleaves APP at 669 site to produce APP669-711, a plasma biomarker for amyloid deposition.2021
- Author(s)
  Miyabishara Yokoyama, Naoki Kaneko, Masaya Matsuzaki, Akihito Korenaga, Sadanori Sekiya, Shinichi Iwamotor, Koichi Tanaka, Taisuke Tomita
- Organizer
  New Horizons in Alzheimer's Disease (Hybrid edition)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] The APP669-711/Aβ1-40 ratio as a plasma biomarker specific for the brain Aβ deposition in APP/PS1 mouse.2021
- Author(s)
  Naoki Kaneko, Masaya Matsuzaki, Miyabishara Yokoyama, Akihito Korenaga, Sadanori Sekiya, Shinichi Iwamoto, Koichi Tanaka, Taisuke Tomita
- Organizer
  AAIC2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] BORCS6はLrrk2ノックアウトマウスにおける層板小体肥大化に関与する2021
- Author(s)
  Miho Araki、Kyohei Ito、Sho Takatori、Genta Ito、Taisuke Tomita
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K06558
[Presentation] The APP669-711/Aβ1-40 as a plasma biomarker for the brain Aβ deposition in APP/PS1 mouse.2021
- Author(s)
  Naoki Kaneko, Masaya Matsuzaki, Miyabishara Yokoyama, Akihito Korenaga, Sadanori Sekiya, Shinichi Iwamoto, Koichi Tanaka, Taisuke Tomita
- Organizer
  第40回日本認知症学会
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] パーキンソン病リスク遺伝子Rab29の生化学的解析2021
- Author(s)
  長井ゆき、伊藤弦太、富田泰輔
- Organizer
  第40回日本認知症学会
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] 自閉症モデルマウスにおけるシナプス形成異常関連分子Lingo2の代謝機構解析2021
- Author(s)
  Shiyori Shun、Fumiaki Yoshida、Genta Ito、Sho Takatori、Taisuke Tomita
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K06558
[Presentation] 電気泳動がひも解くパーキンソン病病因タンパク質の性状と機能2021
- Author(s)
  伊藤弦太
- Organizer
  第71回日本電気泳動学会シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-21K06558
[Presentation] パーキンソン病リスク遺伝子Rab29の生化学的解析2021
- Author(s)
  長井ゆき、伊藤弦太、富田泰輔
- Organizer
  第40回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-21K06558
[Presentation] BORCS6はLrrk2ノックアウトマウスにおける層板小体肥大化に関与する2021
- Author(s)
  荒木美保、伊藤恭平、高鳥翔、伊藤弦太、富田泰輔
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] LRRK2によるリソソーム局在化制御と生物学的意義2021
- Author(s)
  伊藤弦太、伊藤恭平、富田泰輔
- Organizer
  第40回日本認知症学会
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] Regulation of intracellular lysosomal positioning by LRRK22020
- Author(s)
  Kyohei Ito, Genta Ito, Taisuke Tomita
- Organizer
  BIOUT
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] Elucidation of molecular mechanism that induce abnormal excitatory synapse formation in valproic acid-induced rodent model of autism spectrum disorders2020
- Author(s)
  Fumiaki Yoshida, Ryota Nagatomo, Misaki Kimura, Genta Ito, Sho Takatori, Taisuke Tomita
- Organizer
  BIOUT
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] Photo-oxygenation by biocompatible catalyst reduced the Aβ level in the brains of Alzheimer disease model mice2020
- Author(s)
  Shuta Ozawa, Yukiko Hori, Yusuke Shimizu, Atsuhiko Taniguchi, Takanobu Suzuki, Takashi Saito, Takaomi C. Saido, Youhei Sohma, Motomu Kanai, Taisuke Tomita
- Organizer
  BIOUT
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] Characterization of Rab phosphorylation by LRRK2 kinases2019
- Author(s)
  Genta Ito, Kyohei Ito, Miho Araki, Taisuke Tomita
- Organizer
  World Parkinson Congress 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08265
[Presentation] Elucidation of molecular mechanism that induce abnormal excitatory synapse formation in valproic acid-induced rodent model of autism spectrum disorders.2019
- Author(s)
  Fumiaki Yoshida, Ryota Nagatomo, Misaki Kimura, Genta Ito, Sho Takatori, Taisuke Tomita
- Organizer
  Neuroscience 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] Proteomic analysis of lamellar bodies in Lrrk2 knockout mice.2019
- Author(s)
  Miho Araki, Sho Takatori, Genta Ito, Taisuke Tomita
- Organizer
  Neuroscience 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] 層板小体の恒常性維持におけるLRRK2の役割2019
- Author(s)
  伊藤弦太、荒木美保、高鳥翔、富田泰輔
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-17K08265
[Presentation] バルプロ酸母体投与自閉症モデルマウスにおいて興奮性シナプス形成異常をもたらす分子メカニズムの解明2019
- Author(s)
  吉田文明、長友亮太、木村美咲、伊藤弦太、高鳥翔、富田泰輔
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] 層板小体の恒常性維持におけるLRRK2の役割2019
- Author(s)
  伊藤弦太、荒木美保、高鳥翔、富田泰輔
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] Characterization of Rab phosphorylation by LRRK kinases.2019
- Author(s)
  Genta Ito, Kyohei Ito, Miho Araki, Taisuke Tomita
- Organizer
  World Parkinson Congress 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08265
[Presentation] Proteomic analysis of lamellar bodies in Lrrk2 knockout mice2019
- Author(s)
  Miho Araki, Sho Takatori, Genta Ito, Taisuke Tomita
- Organizer
  Neuroscience 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08265
[Presentation] アルツハイマー病リスク因子TREM2/DAP12と相互作用するタンパク質の解明2019
- Author(s)
  木村新伍、高鳥翔、井口明優、荒木美保、伊藤弦太、富田泰輔
- Organizer
  第38回日本認知症学会
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] Systematic analysis on the seeding activity of familial mutant forms of α-synuclein.2019
- Author(s)
  Taisuke Tomita, Nung Xu, Airi Tarutani, Genta Ito
- Organizer
  Neuroscience 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] Physiological role of LRRK2 in lamellar body homeostasis2018
- Author(s)
  Miho Araki, Sho Takatori, Genta Ito, Taisuke Tomita
- Organizer
  2018年度日本生化学会関東支部例会
- Data Source
  KAKENHI-PROJECT-17K08265
[Presentation] Characterization of Rab phosphorylation by LRRK2 kinases2018
- Author(s)
  Genta Ito, Miho Araki, Kyohei Ito, Taisuke Tomita
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K08265
[Presentation] Physiological role of LRRK2 in lamellar body homeostasis2018
- Author(s)
  Miho Araki, Sho Takatori, Genta Ito, Taisuke Tomita
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K08265
[Presentation] Phos-tag SDS-PAGEを用いたRabリン酸化の解析2018
- Author(s)
  Genta Ito
- Organizer
  第69回日本電気泳動学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-17K08265
[Presentation] Phos-tag SDS-PAGEを用いたRabリン酸化の解析2018
- Author(s)
  Genta Ito
- Organizer
  第６９回日本電気泳動学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-17K08265
[Presentation] Phos-tag analysis of Rab10 phosphorylation by LRRK22017
- Author(s)
  Genta Ito
- Organizer
  第３９回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-17K08265
[Presentation] Molecular mechanism of hypophosphorylation of LRRK2 caused by familial mutations2012
- Author(s)
  伊藤弦太、上川路翔悟、岩坪威
- Organizer
  Neuroscience 2012
- Place of Presentation
  New Orleans, USA
- Data Source
  KAKENHI-PROJECT-24790068
[Presentation] Molecular mechanisnl of hypophosphorylation of LRRK2 caused by familial mutations2012
- Author(s)
  Genta Ito, Shogo Kamikawaji, Takeshi Iwatsubo
- Organizer
  米国神経科学会
- Place of Presentation
  ニューオーリンズ、アメリカ合衆国
- Year and Date
  2012-10-15
- Data Source
  KAKENHI-PROJECT-24790068
[Presentation] Identification and functional characterization of novel autophosphorylation sites of LRRK22011
- Author(s)
  Genta Ito
- Organizer
  Neuroscience 2011
- Place of Presentation
  Walter E.Washington Convention Center(アメリカ合衆国)
- Year and Date
  2011-11-13
- Data Source
  KAKENHI-PROJECT-22790058
[Presentation] Identification of in vivo autophosphorylation sites of LRRK2.2011
- Author(s)
  上川路翔悟,伊藤弦太,岩坪威
- Organizer
  米国神経科学会
- Place of Presentation
  ワシントンDC、アメリカ合衆国
- Year and Date
  2011-11-13
- Data Source
  KAKENHI-PROJECT-22790058
[Presentation] Identification and functional characterization of novel autophosphorylation sites of LRRK2.2011
- Author(s)
  伊藤弦太,上川路翔悟,岩坪威
- Organizer
  米国神経科学会
- Place of Presentation
  ワシントンDC、アメリカ合衆国
- Year and Date
  2011-11-13
- Data Source
  KAKENHI-PROJECT-22790058
[Presentation] 家族性パーキンソン病責任遺伝子産物LRRK2の新規基質探索2010
- Author(s)
  新留一樹、伊藤弦太、岩坪威
- Organizer
  第29回日本認知症学会学術集会
- Place of Presentation
  ウインクあいち(愛知県名古屋市)
- Year and Date
  2010-11-05
- Data Source
  KAKENHI-PROJECT-22790058
[Presentation] Biochemical characterization of the dimerization of LRRK22010
- Author(s)
  伊藤弦太、岩坪威
- Organizer
  Neuroscience 2010
- Place of Presentation
  San Diego Convention Center(アメリカ合衆国)
- Year and Date
  2010-11-16
- Data Source
  KAKENHI-PROJECT-22790058
[Presentation] Rotenone treatment enhances apoptosis caused by G2019S familial Park inson mutant LRRK22010
- Author(s)
  功刀隼人、伊藤弦太、岩坪威
- Organizer
  Neuroscience 2010
- Place of Presentation
  San Diego Convention Center(アメリカ合衆国)
- Year and Date
  2010-11-14
- Data Source
  KAKENHI-PROJECT-22790058
[Presentation] Biochemical characterization of the dimerization of LRRK2.2010
- Author(s)
  伊藤弦太,岩坪威
- Organizer
  米国神経科学会
- Place of Presentation
  サンディエゴ、アメリカ合衆国
- Year and Date
  2010-11-16
- Data Source
  KAKENHI-PROJECT-22790058
[Presentation] Rotenone treatment enhances apoptosis caused by G2019S familial Parkinson mutant LRRK2.2010
- Author(s)
  功刀隼人,伊藤弦太,岩坪威
- Organizer
  米国神経科学会
- Place of Presentation
  サンディエゴ、アメリカ合衆国
- Year and Date
  2010-11-14
- Data Source
  KAKENHI-PROJECT-22790058
[Presentation] 家族性パーキンソン病責任遺伝子産物LRRK2の新規基質探索2010
- Author(s)
  新留一樹、伊藤弦太、岩坪威
- Organizer
  日本認知症学会第29回学術集会
- Place of Presentation
  愛知県産業労働センター、愛知県
- Year and Date
  2010-11-05
- Data Source
  KAKENHI-PROJECT-22790058
[Presentation] Characterization of phosphorylation of LRRK22007
- Author(s)
  Genta Ito
- Organizer
  Neuroscience 2007
- Place of Presentation
  サンディエゴ(アメリカ合衆国)
- Year and Date
  2007-11-04
- Data Source
  KAKENHI-PROJECT-18890053

1. IWATSUBO Takeshi (50223409)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
2. WAKABAYASHI Tomoko (20530330)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. HASHIMOTO Tadafumi (30334337)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. Tomita Taisuke (30292957)

# of Collaborated Projects: 1 results

# of Collaborated Products: 30 results
5. 堀由起子 (80610683)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
6. 高鳥翔 (80624361)

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results
7. 樽谷愛理 (10815187)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. 楯直子

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results

Ito Genta 伊藤 弦太

ITO Genta 伊藤 弦太

伊藤 弦太 イトウ ゲンタ

Research Projects

Research Products

Co-Researchers

パーキンソン病発症におけるLRRK2異常活性化メカニズムとその病的意義の解明Principal Investigator

Principal Investigator

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Elucidation of Cellular Pathogenesis as a Key Mechanism for Neurodegenerative Processes in the Pathogenesis of Dementia

Principal Investigator

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Elucidation of the molecular pathogenesis of Parkinson disease by uncovering the LRRK2-Rab pathwayPrincipal Investigator

Principal Investigator

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Research Institution

Membrane localization of LRRK2, a causative gene for familial Parkinson'sPrincipal Investigator

Principal Investigator

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Elucidation of the molecular pathology of Alzheimer's disease focusing on the synapses toward therapies

Principal Investigator

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Research Institution

Characterization of pathophysiological substrates of LRRK2, a causative gene product for familial Parkinson's diseasePrincipal Investigator

Principal Investigator

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Research Institution

家族性パーキンソン病責任遺伝子産物LRRK2の機能解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] LRRK2-mediated phosphorylation and thermal stability of Rab12 areregulated by bound nucleotides2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Pathogenic <scp>LRRK2</scp> compromises the subcellular distribution of lysosomes in a <scp>Rab12‐RILPL1</scp> ‐dependent manner2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Site-specific amino acid D-isomerization of Tau R2 and R3 peptides changes the fibril morphology, resulting in attenuation of Tau aggregation inhibitor potency.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] INPP5D modulates TREM2 loss-of-function phenotypes in a β-amyloidosis mouse model2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] ADAMTS4 is involved in the production of the Alzheimer disease amyloid biomarker APP669-7112023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Overview of the Impact of Pathogenic LKKR2 Mutation Parkinson's Disease2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Lipid flippase dysfunction as a therapeutic target for endosomal anomalies in Alzheimer’s disease2022

Author(s)

Ito Genta 伊藤弦太

ITO Genta 伊藤弦太

伊藤弦太イトウゲンタ