Kubo Norio 久保憲生

… Alternative Names

KUBO NORIO 久保憲生

久保憲生クボノリオ

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Researcher Number	10464744
Other IDs
Affiliation (Current)	2025: 群馬大学, 大学院医学系研究科, 助教
Affiliation (based on the past Project Information) *help	2024: 群馬大学, 大学院医学系研究科, 助教 2015 – 2021: 群馬大学, 医学部附属病院, 助教 2013: 群馬大学, 医学部附属病院, その他
Review Section/Research Field	Principal Investigator 0901:Oncology and related fields / Basic Section 50020:Tumor diagnostics and therapeutics-related Except Principal Investigator Basic Section 55020:Digestive surgery-related / General surgery / Digestive surgery
Keywords	Principal Investigator 肝機能評価マーカー / 肝類洞障害 / 薬剤性肝障害 Except Principal Investigator 癌関連線維芽細胞 / 腫瘍免疫 / PGC-1αマウス / 肝筋連関 / 肝再生率 / PGC1αマウス / 肝筋相関 … More / 分岐鎖アミノ酸 / 肝切除 / 肝再生 / サルコペニア / Galectin 3阻害剤 / マウス皮下腫瘍モデル / 肝胆膵癌 / M2BPGi / 肝胆膵がん / 上皮間葉移行 / PDGF-AA / TGF-β / TGF-Β / FDG / PDGF / 炎症 / エリブリン / TILs / FDG-PET / PD-L1 / VEGF / 乳癌 / 腫瘍血管新生 / 免疫学 / 実験外科学 / 抗原特異的CD8T細胞 / 免疫記憶 / 癌免疫アジュバント療法 / 膵癌 / immune checkpoints / pancreatic cancer / cancer vaccine / 免疫チェックポイント Less

Development of new therapeutic strategies for the treatment of sinusoidal obstruction syndrome caused by anticancer drug therapy.Principal Investigator
- Principal Investigator
  
  久保憲生
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0901:Oncology and related fields
- Research Institution
  Gunma University
肝胆膵の癌におけるユビキチンリガーゼを標的とした革新的治療薬の開発を目指した研究Principal Investigator
- Principal Investigator
  
  久保憲生
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Gunma University
Evaluation of the effect of sarcopenia on liver regeneration from the viewpoint between liver and muscle correlation
- Principal Investigator
  
  Araki Kenichiro
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Gunma University
New humoral factor facilitates hepato-biliary and pancreatic cancer progression and development of innovative thrapy
- Principal Investigator
  
  Shirabe Ken
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Gunma University
Critical role of TGF-beta for functional switch in cancer invasion
- Principal Investigator
  
  FUJII TAKAAKI
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Gunma University
adjuvant therapy
- Principal Investigator
  
  Yajima Toshiki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Gunma University
Development of pancreatic cancer vaccine targeted Immune checkpoints
- Principal Investigator
  
  wada satoshi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kanagawa Cancer Center Research Institute
  Gunma University

All 2021 2020 2019 2016 2015

All Journal Article Presentation

[Journal Article] Hepatic stellate cell as a Mac-2-binding protein-producing cell in patients with liver fibrosis2021
- Author(s)
  Gantumur D, Harimoto N, Muranushi R, Hoshino K, Batbayar C, Hagiwara K, Yamanaka T, Ishii N, Tsukagoshi M, Igarashi T, Watanabe A, Kubo N, Araki K, Yokobori T, Aishima S, Shirabe K.
- Journal Title
  
  Hepatol Res .
  
  Volume: Online ahead of print. Issue: 10 Pages: 1058-1063
- DOI
  10.1111/hepr.13648
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02877
[Journal Article] Conophylline Inhibits Hepatocellular Carcinoma by Inhibiting Activated Cancer-associated Fibroblasts Through Suppression of G Protein-coupled Receptor 682021
- Author(s)
  Yamanaka T, Harimoto N, Yokobori T, Muranushi R, Hoshino K, Hagiwara K, Gantumur D, Handa T, Ishii N, Tsukagoshi M, Igarashi T, Watanabe A, Kubo N, Araki K, Umezawa K, Shirabe K.
- Journal Title
  
  Mol Cancer Ther.
  
  Volume: Online ahead of print. Issue: 6 Pages: 1019-1028
- DOI
  10.1158/1535-7163.mct-20-0150
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02877, KAKENHI-PROJECT-20K16352
[Journal Article] Mac-2-binding protein glycan isomer enhances the aggressiveness of hepatocellular carcinoma by activating mTOR signaling2020
- Author(s)
  Dolgormaa Gantumur、Harimoto Norifumi、Ishii Norihiro、Yamanaka Takahiro、Hagiwara Kei、Tsukagoshi Mariko、Igarashi Takamichi、Watanabe Akira、Kubo Norio、Araki Kenichiro、Handa Tadashi、Yokobori Takehiko、Oyama Tetsunari、Kuwano Hiroyuki、Shirabe Ken
- Journal Title
  
  British Journal of Cancer
  
  Volume: 123 Issue: 7 Pages: 1145-1153
- DOI
  10.1038/s41416-020-0971-y
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16199, KAKENHI-PROJECT-18H02877, KAKENHI-PROJECT-18K07665
[Journal Article] Nintedanib inhibits intrahepatic cholangiocarcinoma aggressiveness via suppression of cytokines extracted from activated cancer-associated fibroblasts2020
- Author(s)
  Yamanaka Takahiro、Harimoto Norifumi、Yokobori Takehiko、Muranushi Ryo、Hoshino Kouki、Hagiwara Kei、Gantumur Dolgormaa、Handa Tadashi、Ishii Norihiro、Tsukagoshi Mariko、Igarashi Takamichi、Tanaka Hiroshi、Watanabe Akira、Kubo Norio、Araki Kenichiro、Shirabe Ken
- Journal Title
  
  British Journal of Cancer
  
  Volume: 122 Issue: 7 Pages: 986-994
- DOI
  10.1038/s41416-020-0744-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02877, KAKENHI-PROJECT-20K16199
[Journal Article] Preoperative Mac‐2 binding protein glycosylation isomer level predicts postoperative ascites in patients with hepatic resection for hepatocellular carcinoma2019
- Author(s)
  Ishii Norihiro、Harimoto Norifumi、Araki Kenichiro、Muranushi Ryo、Hoshino Kouki、Hagiwara Kei、Gantumur Dolgormaa、Yamanaka Takahiro、Tsukagoshi Mariko、Igarashi Takamichi、Tanaka Hiroshi、Watanabe Akira、Kubo Norio、Shirabe Ken
- Journal Title
  
  Hepatology Research
  
  Volume: 49 Issue: 12 Pages: 1398-1405
- DOI
  10.1111/hepr.13412
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02877
[Journal Article] High Co-expression of Large Tenascin C Splice Variants in Stromal Tissue and Annexin A2 in Cancer Cell Membranes is Associated with Poor Prognosis in Pancreatic Cancer2019
- Author(s)
  Hagiwara Kei、Harimoto Norifumi、Yokobori Takehiko、Muranushi Ryo、Hoshino Kouki、Gantumur Dorgormaa、Yamanaka Takahiro、Ishii Norihiro、Tsukagoshi Mariko、Igarashi Takamichi、Tanaka Hiroshi、Watanabe Akira、Kubo Norio、Araki Kenichiro、Hosouchi Yasuo、Shirabe Ken
- Journal Title
  
  Annals of Surgical Oncology
  
  Volume: 27 Issue: 3 Pages: 924-930
- DOI
  10.1245/s10434-019-07708-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02877
[Journal Article] Overexpression of natural killer group 2 member D ligands predicts favorable prognosis in cholangiocarcinoma.2016
- Author(s)
  Tsukagoshi M, Wada S, Yokobori T, Altan B, Ishii N, Watanabe A, Kubo N, Saito F, Araki K, Suzuki H, Hosouchi Y, Kuwano H
- Journal Title
  
  Cancer Science
  
  Volume: 107 Issue: 2 Pages: 116-122
- DOI
  10.1111/cas.12853
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25462103
[Journal Article] Xanthogranulomatous cholecystitis: Difficulty in differentiating from gallbladder cancer.2015
- Author(s)
  Suzuki H, Wada S, Araki K, Kubo N, Watanabe A, Tsukagoshi M, Kuwano H.
- Journal Title
  
  World J Gastroenterol.
  
  Volume: 21 Issue: 35 Pages: 10166-10173
- DOI
  10.3748/wjg.v21.i35.10166
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25462103
[Presentation] サルコペニアにおける肝切除後肝再生抑制に関する基礎的研究2021
- Author(s)
  萩原慶、播本憲史、新木健一郎、久保憲生、渡辺亮、五十嵐隆通、塚越真梨子、石井範洋、星野弘毅、村主遼、調憲
- Organizer
  第121 回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-19K09163
[Presentation] サルコペニアにおける肝切除後肝再生抑制に関する基礎的研究2021
- Author(s)
  萩原慶、播本憲史、新木健一郎、久保憲生、渡辺亮、五十嵐隆通、塚越真梨子、石井範洋、星野弘毅、村主遼、調憲
- Organizer
  第121回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-19K09163
[Presentation] 癌関連線維芽細胞が産生するサイトカインの制御に基づく，肝癌の新たな治療戦略2020
- Author(s)
  山中崇弘、播本憲史、村主遼、星野弘毅、萩原慶、石井範洋、塚越真梨子、五十嵐隆通、渡辺亮、久保憲生、新木健一郎、梅澤一夫、調憲
- Organizer
  第120回日本外科学会
- Data Source
  KAKENHI-PROJECT-18H02877
[Presentation] Analysis of the immune suppression mechanism in extra-hepatic cholangiocarcinoma.2015
- Author(s)
  Wada S, Tsukagoshi M, Watanabe A, Kubo N, Araki K, Suzuki H, Kuwano　H.
- Organizer
  AACR(American Association for Cancer Research) 106th Annual Meeting
- Place of Presentation
  Philadelphia, USA
- Year and Date
  2015-04-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25462103
[Presentation] Clinicopathological implications of newly defined immune checkpoints in Extra-Hepatic CholangioCarcinoma.2015
- Author(s)
  Wada S, Tsukagoshi M, Watanabe A, Kubo N, Araki K, Suzuki H, Kuwano H.
- Organizer
  ASCO(American Society of Clinical Oncology) 51 th Annual Meeting
- Place of Presentation
  Chicago, USA
- Year and Date
  2015-05-29
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25462103

1. Shirabe Ken (70264025)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
2. Araki Kenichiro (60431706)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
3. 播本憲史 (00419582)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
4. 塚越真梨子 (60781317)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
5. wada satoshi (30420102)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
6. SUZUKI HIDEKI (20322018)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
7. KUWANO HIROYUKI (90186560)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
8. Yajima Toshiki (20346852)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. FUJII TAKAAKI (40507331)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 茂木晃 (10323362)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 堤荘一 (30323356)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 高坂貴行 (00507329)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 伊部崇史 (80826264)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 東陽子 (30770002)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 宮崎達也 (70372349)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 清水公裕 (90375535)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 高田考大 (00781311)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 矢島玲奈 (10431701)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 黒住献 (40768735)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 尾林紗弥香 (10648471)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 石井範洋 (00711508)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
22. 五十嵐隆通 (20648472)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
23. 市川聡 (60333621)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 横堀武彦 (60420098)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
25. 渡辺亮 (60738847)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
26. 半田正

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kubo Norio 久保 憲生

KUBO NORIO 久保 憲生

久保 憲生 クボ ノリオ

Research Projects

Research Products

Co-Researchers

Development of new therapeutic strategies for the treatment of sinusoidal obstruction syndrome caused by anticancer drug therapy.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

肝胆膵の癌におけるユビキチンリガーゼを標的とした革新的治療薬の開発を目指した研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Evaluation of the effect of sarcopenia on liver regeneration from the viewpoint between liver and muscle correlation

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

New humoral factor facilitates hepato-biliary and pancreatic cancer progression and development of innovative thrapy

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Critical role of TGF-beta for functional switch in cancer invasion

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

adjuvant therapy

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of pancreatic cancer vaccine targeted Immune checkpoints

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Hepatic stellate cell as a Mac-2-binding protein-producing cell in patients with liver fibrosis2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Conophylline Inhibits Hepatocellular Carcinoma by Inhibiting Activated Cancer-associated Fibroblasts Through Suppression of G Protein-coupled Receptor 682021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mac-2-binding protein glycan isomer enhances the aggressiveness of hepatocellular carcinoma by activating mTOR signaling2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Nintedanib inhibits intrahepatic cholangiocarcinoma aggressiveness via suppression of cytokines extracted from activated cancer-associated fibroblasts2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Preoperative Mac‐2 binding protein glycosylation isomer level predicts postoperative ascites in patients with hepatic resection for hepatocellular carcinoma2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] High Co-expression of Large Tenascin C Splice Variants in Stromal Tissue and Annexin A2 in Cancer Cell Membranes is Associated with Poor Prognosis in Pancreatic Cancer2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Overexpression of natural killer group 2 member D ligands predicts favorable prognosis in cholangiocarcinoma.2016

Author(s)

Kubo Norio 久保憲生

KUBO NORIO 久保憲生

久保憲生クボノリオ

[Presentation] サルコペニアにおける肝切除後肝再生抑制に関する基礎的研究2021

[Presentation] サルコペニアにおける肝切除後肝再生抑制に関する基礎的研究2021

[Presentation] 癌関連線維芽細胞が産生するサイトカインの制御に基づく，肝癌の新たな治療戦略2020