Watanabe Bunta 渡辺文太

… Alternative Names

渡辺文太ワタナベブンタ

WATANABE Bunta 渡辺文太

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Researcher Number	10544637
Other IDs
Affiliation (Current)	2025: 東京慈恵会医科大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2022 – 2023: 東京慈恵会医科大学, 医学部, 准教授 2019 – 2021: 京都大学, 化学研究所, 助教 2009 – 2016: Kyoto University, 化学研究所, 助教
Review Section/Research Field	Principal Investigator Basic Section 38040:Bioorganic chemistry-related / Biomolecular chemistry / Chemical biology / Living organism molecular science Except Principal Investigator Basic Section 38030:Applied biochemistry-related / Structural biochemistry / Chemical biology / Living organism molecular science
Keywords	Principal Investigator 有機合成化学 / 生合成 / ナス科植物 / 配糖体 / ステロイドグリコアルカロイド / 抗体依存性細胞傷害 / 分子プローブ / GGsTop / 酵素阻害剤 / GGT … More / γ-グルタミルトランスペプチダーゼ / エーテル型リン脂質 / 脂質プローブ / 脂質 / アーキア / ケミカルバイオロジー / 脂質生物学 / 蛍光ラベル / 化学プローブ / エーテル型膜脂質 / 古細菌 / 有機化学 / ドラッグデザイン / 化学療法剤 / 感染症 / グルタチオン / 酵素反応 / 有機科学 … More Except Principal Investigator X線結晶構造解析 / 遷移状態アナログ阻害剤 / 匂い応答 / ケミカルプローブ / 嗅覚 / プロテアーゼインヒビター / カルシウムシグナル / 化学感覚 / ヘキセノール / トウモロコシ / 誘導防衛 / カルシウム動態 / 構造活性相関解析 / みどりの香り / 植物嗅覚 / 薬理学 / X線結晶解析 / 多剤耐性 / ＡＢＣトランスポーター / 生体膜及び受容体 / 受容体 / 構造機能相関 / 生体膜 / 薬物標的 / 細胞死誘導 / アスパラギナーゼ療法 / アシル活性化酵素 / アデノシンミミック / アシルアデニル酸中間体 / 化学療法 / 急性リンパ性白血病 / ヒトアスパラギン合成酵素 / acivicin / グルタミンアンタゴニスト / 部位特異的変異 / 基質認識残基 / ヒトGGT / 活性中心マッピング / ホスホン酸ジエステル / 反応機構依存的阻害剤 / γ-グルタミルシスティン合成酵素 / 酸化ストレス / 急性腎障害 / 細胞レドックスポテンシャル / ヒト線維芽細胞 / 反応機構依存型阻害剤 / γ-グルタミルトランスペプチダーゼ / 急性腎障害軽減 / アンチェイジング化粧品 / 病原性連鎖球菌 / 酸化ストレス制御 / γ-グルテミルシランスペプチダーゼ / γ-グルタミルシステイン合成酵素 / グルタチオン Less

Study on biosynthesis of steroidal glycoalkaloids in Solanaceae plants based on organic synthetic chemistryPrincipal Investigator
- Principal Investigator
  
  渡辺文太
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38040:Bioorganic chemistry-related
- Research Institution
  Jikei University School of Medicine
Plant olfaction: the process of recognizing volatile compounds and converting them into biological signals
- Principal Investigator
  
  Matsui Kenji
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 38030:Applied biochemistry-related
- Research Institution
  Yamaguchi University
Synthesis of gamma-glutamyl transpeptidase-specific chemical probes and their application to cancer immunotherapyPrincipal Investigator
- Principal Investigator
  
  WATANABE Bunta
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biomolecular chemistry
- Research Institution
  Kyoto University
Elucidation of Multidrug recognition mechanism of ABC transporter and development of its novel inhibitor
- Principal Investigator
  
  Kato Hiroaki
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Structural biochemistry
- Research Institution
  Kyoto University
Study on the biosynthesis and the dynamics of archaeal membrane lipids using synthetic lipid probesPrincipal Investigator
- Principal Investigator
  
  WATANABE Bunta
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Chemical biology
- Research Institution
  Kyoto University
Drug design based on asparagine synthetase inhibitors
- Principal Investigator
  
  HIRATAKE Jun
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical biology
- Research Institution
  Kyoto University
Development of novel regulators for controlling glutathione biosynthesisPrincipal Investigator
- Principal Investigator
  
  WATANABE Bunta
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Living organism molecular science
- Research Institution
  Kyoto University
Development of chemicals that control the glutathione metabolism and oxidative stress and their use for chemical biology
- Principal Investigator
  
  HIRATAKE Jun
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Living organism molecular science
- Research Institution
  Kyoto University

All 2021 2015 2014 2013 2012 2011 2010

All Journal Article Presentation Patent

[Journal Article] Transcriptional regulators involved in responses to volatile organic compounds in plants2021
- Author(s)
  Ayumi Nagashima‐KASAHARA, Takumi Higaki, Takao Koeduka, Ken Ishigami, Satoko Hosokawa, Hidenori Watanabe, Kenji Matsui, Seiichiro Hasezawa, Kazushige Touhara
- Journal Title
  
  The FASEB Journal
  
  Volume: 35 Issue: S1 Pages: 00109-00109
- DOI
  10.1096/fasebj.2021.35.s1.00109
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H02887
[Journal Article] Structure-activity relationship studies of insect and plant steroid hormones2015
- Author(s)
  Watanabe, B.
- Journal Title
  
  Journal of Pesticide Science
  
  Volume: 40 Issue: 3 Pages: 146-151
- DOI
  10.1584/jpestics.J15-04
- NAID
  130005094226
- ISSN
  1348-589X, 1349-0923
- Language
  English
- Open Access
- Data Source
  KAKENHI-PROJECT-25251006
[Journal Article] グルタチオン代謝とチオールケミストリー2015
- Author(s)
  渡辺文太；平竹潤
- Journal Title
  
  化学と生物
  
  Volume: 53 Pages: 354-361
- Data Source
  KAKENHI-PROJECT-25251006
[Journal Article] Synthesis and Inhibitory Activity of Substrate-Analog Fructosyl Peptide Oxidase Inhibitors2015
- Author(s)
  Watanabe, B.; Ichiyanagi, A.; Hirokawa, K.; Gomi, K.; Nakatsu, T.; Kato, H.; Kajiyama, N.
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 25 Issue: 18 Pages: 3910-3913
- DOI
  10.1016/j.bmcl.2015.07.045
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25251006
[Journal Article] Stereospecific Inhibitory Effects of CCG-1423 on the Cellular Events Mediated by Myocardin-Related Transcription Factor A2015
- Author(s)
  渡辺文太、南沙紀、石田秀明、吉岡隆三、中川好秋、森田強、林謙一郎
- Journal Title
  
  PLOS ONE
  
  Volume: 10(8) Issue: 8 Pages: e0136242-e0136242
- DOI
  10.1371/journal.pone.0136242
- NAID
  120005763438
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K07076, KAKENHI-PROJECT-25251006
[Journal Article] Glutathione-analogous peptidyl phosphorus esters as mechanism-based inhibitors of c-glutamyl transpeptidase for probing cysteinyl-glycine binding site2014
- Author(s)
  Mado Nakajima,Bunta Watanabe, Liyou Han, Bun-ichi Shimizu, Kei Wada, Keiichi Fukuyama, Hideyuki Suzuki, Jun Hiratake
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 22 Issue: 3 Pages: 1176-1194
- DOI
  10.1016/j.bmc.2013.12.034
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23510278
[Journal Article] Structural basis for gating mechanisms of a eukaryotic P-glycoprotein homolog2014
- Author(s)
  Atsushi Kodan, Tomohiro Yamaguchi, Toru Nakatsu, Keita Sakiyama, Christopher Hipolito, Akane Fujioka, Ryo Hirokane, Keiji Ikeguchi, Bunta Watanabe, Jun Hiratake, Yasuhisa Kimura, Hiroaki Suga, Kazumitsu Ueda, Hiroaki Kato
- Journal Title
  
  Proceedings of the National Academy of Sciences of the United States of America
  
  Volume: 111 Issue: 11 Pages: 4049-4054
- DOI
  10.1073/pnas.1321562111
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659018, KAKENHI-PROJECT-24689029, KAKENHI-PROJECT-25221203, KAKENHI-PROJECT-25251006
[Journal Article] A sulfoximine-based inhibitor of human asparagine synthetase kills L-asparaginase-resistant leukemia cells2012
- Author(s)
  Ikeuchi, Hideyuki; Ahn, Yong-Mo; Otokawa, Takuya; Watanabe, Bunta; Hegazy, Lamees; Hiratake, Jun; Richards, Nigel G. J.
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 20 Issue: 19 Pages: 5915-5927
- DOI
  10.1016/j.bmc.2012.07.047
- NAID
  120004874002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23510278
[Patent] 腎不全治療剤2010
- Inventor(s)
  平竹潤, 渡辺文太, 松村靖夫
- Industrial Property Rights Holder
  国立大学法人京都大学
- Industrial Property Number
  2010-032161
- Filing Date
  2010-02-17
- Data Source
  KAKENHI-PROJECT-19310143
[Patent] 腎不全治療剤2010
- Inventor(s)
  平竹潤, 渡辺文太, 松村靖夫, 大喜多守
- Industrial Property Rights Holder
  国立大学法人京都大学
- Industrial Property Number
  2010-032161
- Filing Date
  2010-02-17
- Data Source
  KAKENHI-PROJECT-19310143
[Presentation] 4-クマル酸：CoAリガーゼ阻害剤の合成と阻害活性の評価2013
- Author(s)
  平竹　潤、切替宏彰、肥塚崇男、渡辺文太
- Organizer
  日本農芸化学会2013年度（平成25 年度）大会
- Place of Presentation
  東北大学（仙台）
- Data Source
  KAKENHI-PROJECT-23510278
[Presentation] 4-クマル酸:CoAリガーゼ阻害剤の合成と阻害活性の評価2013
- Author(s)
  平竹潤、切替宏彰、肥塚崇男、渡辺文太
- Organizer
  日本農芸化学会2013年度(平成25年度)大会
- Place of Presentation
  東北大学(仙台)
- Data Source
  KAKENHI-PROJECT-23510278
[Presentation] アスパラギン合成酵素の新規阻害剤の創製ーガン化学療法への新展開ー2012
- Author(s)
  池内秀幸、Yong-Mo Ahn、音川拓哉、渡辺文太、Nigel G. J. Richards、平竹　潤
- Organizer
  日本農芸化学会2012年度大会
- Place of Presentation
  京都女子大学
- Data Source
  KAKENHI-PROJECT-23510278
[Presentation] アスパラギン合成酵素の新規阻害剤の創製 ―ガン化学療法への新展開 ―2012
- Author(s)
  池内秀幸、 Yong-Mo Ahn、音川拓哉、渡辺文太、Nigel G. J. Richards、平竹潤
- Organizer
  日本農芸化学会2012年度大会
- Place of Presentation
  京都女子大学
- Year and Date
  2012-03-25
- Data Source
  KAKENHI-PROJECT-23510278
[Presentation] アスパラギン合成酵素阻害剤の合成ー急性リンパ性白血病の新規治療剤を目指してー2011
- Author(s)
  池内秀幸、Yong-Mo Ahn、音川拓哉、渡辺文太、Nigel G. J. Richards、平竹　潤
- Organizer
  日本農芸化学会関西支部・中部支部合同大会
- Place of Presentation
  京都大学農学部
- Data Source
  KAKENHI-PROJECT-23510278
[Presentation] アスパラギン合成酵素の新規阻害剤の創製ーガン化学療法への新展開ー2011
- Author(s)
  池内秀幸、Yong-Mo Ahn、音川拓哉、渡辺文太、Nigel G. J. Richards、平竹　潤
- Organizer
  京都大学化学研究所　第111回研究発表会
- Place of Presentation
  京都大学化学研究所
- Data Source
  KAKENHI-PROJECT-23510278
[Presentation] γ-グルタミルシステイン合成酵素(γ-GCS)阻害剤に基づいた抗菌剤の創製研究2011
- Author(s)
  山本有紀、渡辺文太、日び隆雄、平竹潤
- Organizer
  日本農芸化学会2011年度大会
- Place of Presentation
  京都
- Year and Date
  2011-03-27
- Data Source
  KAKENHI-PROJECT-21810015
[Presentation] アスパラギン合成酵素阻害剤の合成-急性リンパ性白血病の新規治療剤を目指して-2011
- Author(s)
  池内秀幸、 Yong-Mo Ahn、音川拓哉、渡辺文太、Nigel G. J. Richards、平竹潤
- Organizer
  日本農芸化学会関西支部・中部支部合同大会
- Place of Presentation
  京都大学農学部
- Year and Date
  2011-10-01
- Data Source
  KAKENHI-PROJECT-23510278
[Presentation] γ-グルタミルシステイン合成酵素(γ-GCS)阻害剤に基づいた新規抗菌剤の創製研究2011
- Author(s)
  山本有紀, 渡辺文太, 日び隆雄, 平竹潤
- Organizer
  日本農芸化学会2011年度大会
- Place of Presentation
  京都
- Year and Date
  2011-03-27
- Data Source
  KAKENHI-PROJECT-21810015
[Presentation] アスパラギン合成酵素の新規阻害剤の創製-ガン化学療法への新展開-2011
- Author(s)
  池内秀幸、 Yong-Mo Ahn、音川拓哉、渡辺文太、Nigel G. J. Richards、平竹潤
- Organizer
  京都大学化学研究所第111回研究発表会
- Place of Presentation
  京都大学化学研究所
- Year and Date
  2011-12-09
- Data Source
  KAKENHI-PROJECT-23510278
[Presentation] 腎虚血再灌流傷害に対する新規GGT阻害剤の改善効果について2010
- Author(s)
  山本真也, 渡辺文太, 平竹潤, 大喜多守, 松村靖夫
- Organizer
  第83回日本薬理学会年会 The 83rd Annual Meeting of the Japanese Pharmacological Society
- Place of Presentation
  大阪国際会議場
- Year and Date
  2010-03-16
- Data Source
  KAKENHI-PROJECT-19310143

1. HIRATAKE Jun (80199075)

# of Collaborated Projects: 3 results

# of Collaborated Products: 13 results
2. SHIMIZU Bunichi (50324695)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. MIZUTANI Masaharu (60303898)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. HIBI Takao (00285181)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. Kato Hiroaki (90204487)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. NAKATSU Toru (50293949)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. YAMAGUCHI Tomohiro (80346791)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. Matsui Kenji (90199729)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. 高林純示 (10197197)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 岡田憲典 (20312241)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. MORITA Tsuyoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 日〓隆雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Watanabe Bunta 渡辺 文太

渡辺 文太 ワタナベ ブンタ

WATANABE Bunta 渡辺 文太

Research Projects

Research Products

Co-Researchers

Study on biosynthesis of steroidal glycoalkaloids in Solanaceae plants based on organic synthetic chemistryPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Plant olfaction: the process of recognizing volatile compounds and converting them into biological signals

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Synthesis of gamma-glutamyl transpeptidase-specific chemical probes and their application to cancer immunotherapyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of Multidrug recognition mechanism of ABC transporter and development of its novel inhibitor

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study on the biosynthesis and the dynamics of archaeal membrane lipids using synthetic lipid probesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Drug design based on asparagine synthetase inhibitors

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of novel regulators for controlling glutathione biosynthesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of chemicals that control the glutathione metabolism and oxidative stress and their use for chemical biology

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Transcriptional regulators involved in responses to volatile organic compounds in plants2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Structure-activity relationship studies of insect and plant steroid hormones2015

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] グルタチオン代謝とチオールケミストリー2015

Author(s)

Journal Title

Data Source

[Journal Article] Synthesis and Inhibitory Activity of Substrate-Analog Fructosyl Peptide Oxidase Inhibitors2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Stereospecific Inhibitory Effects of CCG-1423 on the Cellular Events Mediated by Myocardin-Related Transcription Factor A2015

Author(s)

Journal Title

DOI

Watanabe Bunta 渡辺文太

渡辺文太ワタナベブンタ

WATANABE Bunta 渡辺文太