OKAMURA Ayako 岡村文子

… Alternative Names

出町文子

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Researcher Number	10546948
Other IDs
Affiliation (based on the past Project Information) *help	2024: 愛知県がんセンター(研究所), 腫瘍免疫制御TR分野, 主任研究員 2019 – 2022: 愛知県がんセンター(研究所), 腫瘍免疫制御TR分野, 主任研究員 2018: 愛知県がんセンター(研究所), 腫瘍免疫応答研究分野, 主任研究員 2015 – 2017: 愛知県がんセンター(研究所), 腫瘍免疫学部, 主任研究員 2011 – 2014: 愛知県がんセンター(研究所), 腫瘍免疫学部, 研究員 2013: 愛知県がんセンター研究所, 研究員
Review Section/Research Field	Principal Investigator Basic Section 55040:Respiratory surgery-related / Basic Section 55020:Digestive surgery-related / Tumor therapeutics / Immunology / Tumor immunology Except Principal Investigator Medium-sized Section 90:Biomedical engineering and related fields / Basic Section 50020:Tumor diagnostics and therapeutics-related / Digestive surgery
Keywords	Principal Investigator CTL / オートファジー / 腫瘍免疫 / エピトープ / TCR / 膵臓癌 / 免疫 / がん / 肺癌 / MR1 … More / T細胞 / K-RAS / エピトープペプチド / 膵臓がん / 免疫療法 / K-ras / 膵癌 / マススペクトロメトリー / 抗原提示 / 細胞傷害性Tリンパ球 … More Except Principal Investigator T細胞受容体 / 一細胞シークエンス / 免疫細胞受容体 / 一細胞計測 / 機械学習 / ベイズモデル / ペプチドHLA複合体 / タンパク質デザイン / TCR / 補体 / 膜侵襲複合体 / がん特異的TCR / 親和性の成熟 / Ｔ細胞受容体 / ナチュラルキラーT細胞 / 免疫療法 / 樹状細胞 / NKT細胞 / がん / 癌 / 免疫 / 膵臓癌 / 外科 Less

Analysis on T cells that are specific for MR1-restricted targets derived from tumorsPrincipal Investigator
- Principal Investigator
  
  岡村文子 (出町文子)
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  Aichi Cancer Center Research Institute
Development of protein design methods for T cell receptors with immune single cell sequencing data analysis
- Principal Investigator
  
  Yamaguchi Rui
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 90:Biomedical engineering and related fields
- Research Institution
  Aichi Cancer Center Research Institute
Investigation of CTL epitopes specific for autophagy-activated pancreatic cancerPrincipal Investigator
- Principal Investigator
  
  Demachi-Okamura Ayako
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Aichi Cancer Center Research Institute
Affinity maturation of cancer-specific TCRs by in vitro cell display methods and their application to drug discovery.
- Principal Investigator
  
  OHTA RIEKO
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Nagoya City University
Investigation of immunotherapy targeting an epitope generated through autophagy.Principal Investigator
- Principal Investigator
  
  DEMACHI-OKAMURA Ayako
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Aichi Cancer Center Research Institute
Analysis of antigen presentation mediated with constitutively active autophagy that induced by K-ras mutationPrincipal Investigator
- Principal Investigator
  
  Demachi-Okamura Ayako
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  Aichi Cancer Center Research Institute
Invariant NKT cell-based effector T cell expressing a tumor reactive T cell receptor, as a possible cell medicine for pancreatic cancer
- Principal Investigator
  
  UEMURA Yasushi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Aichi Cancer Center Research Institute
Identification of CTL epitope using mass spectrometer.Principal Investigator
- Principal Investigator
  
  OKAMURA Ayako
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor immunology
- Research Institution
  Aichi Cancer Center Research Institute

All 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 Other

All Journal Article Presentation Book

[Book] がん免疫療法の個別化を支える新・腫瘍免疫学2019
- Author(s)
  高橋祐介、岡村文子、松下博和
- Total Pages
  267
- Publisher
  羊土社
- ISBN
  9784758103817
- Data Source
  KAKENHI-PROJECT-19K09232
[Book] 臨床免疫・アレルギー科2014
- Author(s)
  岡村文子、葛島清隆
- Total Pages
  4
- Publisher
  科学評論社
- Data Source
  KAKENHI-PROJECT-25871227
[Journal Article] New evaluation of the tumor immune microenvironment of non-small cell lung cancer and its association with prognosis2022
- Author(s)
  Shinohara Shuichi、Takahashi Yusuke、Demachi-Okamura Ayako et al.
- Journal Title
  
  Journal for ImmunoTherapy of Cancer
  
  Volume: 10 Issue: 4 Pages: e003765-e003765
- DOI
  10.1136/jitc-2021-003765
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09232, KAKENHI-PROJECT-19H03528, KAKENHI-PROJECT-20K09187
[Journal Article] Identification of neoantigens and development of antigen-specific immunotherapy2020
- Author(s)
  Shinohara S., Takahashi Y., Demachi-Okamura A., Matsuhita H.
- Journal Title
  
  Rinsho Ketsueki
  
  Volume: 61 Issue: 9 Pages: 1433-1439
- DOI
  10.11406/rinketsu.61.1433
- NAID
  130007937112
- ISSN
  0485-1439, 1882-0824
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-19K09232
[Journal Article] Improving TCR affinity on 293T cells2019
- Author(s)
  Ohta Rieko、Demachi-Okamura Ayako、Akatsuka Yoshiki、Fujiwara Hiroshi、Kuzushima Kiyotaka
- Journal Title
  
  Journal of Immunological Methods
  
  Volume: 466 Pages: 1-8
- DOI
  10.1016/j.jim.2018.11.010
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07285, KAKENHI-PROJECT-18K08341, KAKENHI-PROJECT-18K08361, KAKENHI-PROJECT-16K07192, KAKENHI-PROJECT-17K07238
[Journal Article] Frequent structural variations involving programmed death ligands in Epstein-Barr virus-associated lymphomas2019
- Author(s)
  Kataoka Keisuke, Miyoshi Hiroaki, Sakata Seiji, Dobashi Akito, Couronne Lucile, Kogure Yasunori, Sato Yasuharu, Nishida Kenji, Gion Yuka, Shiraishi Yuichi, Tanaka Hiroko, et al
- Journal Title
  
  Leukemia
  
  Volume: Epub ahead of print Issue: 7 Pages: 1687-1699
- DOI
  10.1038/s41375-019-0380-5
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07205, KAKENHI-PROJECT-17K10136, KAKENHI-PLANNED-15H05909, KAKENHI-PLANNED-15H05912, KAKENHI-PLANNED-26115009, KAKENHI-PROJECT-16H05338, KAKENHI-PROJECT-19K09232, KAKENHI-PROJECT-19H05656, KAKENHI-PROJECT-19H01053, KAKENHI-PROJECT-17K18335
[Journal Article] ネオアンチゲンはがんに対するナチュラルに誘導されるあるいは治療により誘導される免疫応答の重要な標的である2019
- Author(s)
  松下博和、岡村文子、高橋祐介
- Journal Title
  
  癌と化学療法
  
  Volume: 46 Pages: 1372-1376
- Data Source
  KAKENHI-PROJECT-19K09232
[Journal Article] Induction of HLA-B*40:02-restricted T cells possessing cytotoxic and suppressive functions against haematopoietic progenitor cells from a patient with severe aplastic anaemia.2015
- Author(s)
  Inaguma Y, Akatsuka Y, Hosokawa K, Maruyama H, Okamoto A, Katagiri T, Shiraishi K, Murayama Y, Tsuzuki-Iba S, Mizutani Y, Nishii C, Yamamoto N, Demachi-Okamura A, Kuzushima K, Ogawa S, Emi N, Nakao S.
- Journal Title
  
  Br J Haematol.
  
  Volume: in press Issue: 1 Pages: 131-134
- DOI
  10.1111/bjh.13464
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24591435, KAKENHI-PROJECT-15K09512, KAKENHI-PROJECT-26462701, KAKENHI-PROJECT-15K15360, KAKENHI-PROJECT-14F04419, KAKENHI-PROJECT-25871227, KAKENHI-PLANNED-15H05909, KAKENHI-PROJECT-26221308
[Journal Article] Identification of a naturally processed HLA-Cw7-binding peptide that cross-reacts with HLA-A24-restricted ovarian cancer-specific CTLs.2015
- Author(s)
  Yamada E, Demachi-Okamura A, Kondo S, Akatsuka Y, Suzuki S, Shibata K, Kikkawa F, Kuzushima K.
- Journal Title
  
  Tissue Antigens
  
  Volume: 86(3) Issue: 3 Pages: 164-71
- DOI
  10.1111/tan.12607
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K20138, KAKENHI-PROJECT-25871227
[Journal Article] An HLA-modified ovarian cancer cell line induced CTL responses specific to an epitope derived from claudin-1 presented by HLA-A*24:02 molecules2013
- Author(s)
  Kondo S, Demachi-Okamura A, Hirosawa T, Maki H, Fujita M, Uemura Y, Akatsuka Y, Yamamoto E, Shibata K, Ino K, Kikkawa F, Kuzushima K.
- Journal Title
  
  Hum Immunol
  
  Volume: 74 Issue: 9 Pages: 1103-1110
- DOI
  10.1016/j.humimm.2013.06.030
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592022, KAKENHI-PROJECT-24591435, KAKENHI-PROJECT-24659727, KAKENHI-PROJECT-25871227
[Journal Article] Zoledronate sensitizes neuroblastoma-derived tumor-initiating cells to cytolysis mediated by humanγδT cells2012
- Author(s)
  Nishio N., Fujita M., Tanaka Y., Maki H., Zhang R, Hirosawa T., Demachi-Okamura A., Uemura Y., Taguchi O., Takahashi Y., Kojima S., Kuzushima K.
- Journal Title
  
  J . Immunother.
  
  Volume: 35 Pages: 598-606
- Data Source
  KAKENHI-PROJECT-23592022
[Journal Article] Autophagy creates a CTL epitope that mimics tumor-associated antigens.2012
- Author(s)
  Demachi-Okamura A
- Journal Title
  
  PLoS ONE
  
  Volume: 7 Issue: 10 Pages: e47126-e47126
- DOI
  10.1371/journal.pone.0047126
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23701079
[Presentation] Single Cell解析を活用した非小細胞性肺癌におけるネオ抗原および癌・精巣抗原特異的なCD8+T細胞集団の同定2022
- Author(s)
  小室裕康、篠原周一、福嶋恭啓、杉田裕介、松井琢哉、高橋祐介、岡村文子、村岡大輔、福山隆、浜名洋、岸裕幸、田中雄希、尾上広祐、小野口和英、山下慶子、山口類、黒田浩章、岩田尚、松下博和
- Organizer
  第26回日本がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-21K19939
[Presentation] HLA-B1501肺癌患者におけるKK-LC-1に対するTCRの取得2021
- Author(s)
  小室裕康、高橋祐介、宮本勇作、松本光善、山本裕崇、白橋幸洋、西田玲奈、宮井まなみ、篠原周一、松井琢哉、岡村文子、福山隆、黒田浩章、松下博和、土井潔、岩田尚
- Organizer
  第38回日本呼吸器外科学会
- Data Source
  KAKENHI-PROJECT-21K19939
[Presentation] ヒト培養細胞を用いたTCR親和性成熟システムの樹立2018
- Author(s)
  太田里永子、岡村文子、赤塚美樹、葛島清隆
- Organizer
  第22回日本がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-18K07285
[Presentation] Frequent somatic alterations involving pro- grammed death ligands in EBV-related lymphomas2017
- Author(s)
  片岡圭亮、三好寛明、岡村文子、坂田征士、Lucile Couronne、木暮泰寛、土橋映仁、佐藤康晴、西田賢司、白石友一、田中洋子、千葉健一、綿谷陽作、塩澤裕介、吉田健一、真田昌、加藤元博、葛島清隆、宮野悟、大田泰徳、伊豆津宏二、吉野正、Olivier Hermine、竹内賢吾、赤塚美樹、大島孝一、小川誠司
- Organizer
  第79回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-16K07192
[Presentation] がん細胞では異常なTAP分子によりエピトープを提示する2016
- Author(s)
  岡村文子
- Organizer
  第8回血液疾患免疫療法学会
- Place of Presentation
  北海道大学学友会館フラテ（札幌市）
- Data Source
  KAKENHI-PROJECT-16K07192
[Presentation] An analysis of TAP-independent epitope created in cancerous cells2015
- Author(s)
  Ayako Okamura1, Yoshiki Akatsuka, Kiyotaka Kuzushima
- Organizer
  The 74th Annual Meeting of the Japanese Cancer Association
- Place of Presentation
  名古屋国際会議場（名古屋市）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-25871227
[Presentation] 人工抗原提示細胞を用いたCTLの誘導とがん細胞特異的エピトープ生成過程について2014
- Author(s)
  岡村文子，葛島清隆
- Organizer
  日本がん免疫学会
- Place of Presentation
  ひめぎんホール（松山市）
- Year and Date
  2014-08-01
- Invited
- Data Source
  KAKENHI-PROJECT-25871227
[Presentation] TRAILを発現する多能性幹細胞由来ミエロイド細胞を用いた細胞医薬の開発2013
- Author(s)
  牧寛之, 植村靖史, 張エイ, 竹田和由, 劉天懿, 鈴木元晴, 都築忍, 岡村文子, 赤塚美樹, 西村泰治, 千住覚, 葛島清隆
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-23592022
[Presentation] TRAILを発現する多能性幹細胞由来ミエロイド細胞を用いた細胞医薬の開発2013
- Author(s)
  牧寛之, 植村靖史, 張エイ, 竹田和由, 劉天懿, 鈴木元晴, 都築忍, 岡村文子, 赤塚美樹, 西村泰治, 千住覚, 葛島清隆
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（横浜市）
- Data Source
  KAKENHI-PROJECT-23592022
[Presentation] Zoledronate sensitizes neuroblastoma-derived tumor-initiating cells to cytolysis mediated by human gamma-delta T cells2012
- Author(s)
  西尾信博, 藤田貢, 田中義正, 牧寛之, 張エイ, 岡村文子, 植村靖史, 田口修, 高橋義行, 小島勢二, 葛島清隆
- Organizer
  第4回造血器腫瘍免疫療法研究会学術集会
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-23592022
[Presentation] Tumor-reactive TCR gene-transduced invariant NKT cells as a possible tool for cancer immunotherapy2012
- Author(s)
  Yasushi Uemura, Junichi Mineno, Hiroaki Ikeda, Tianyi Liu, Hiroyuki Maki, Shinji Kondo, Rong Zhang, Ayako Okamura, Mitsugu Fujita, Yoshiki Akatsuka, Yoshiaki Sonoda, Hiroshi Shiku, and Kiyotaka Kuzushima
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌市
- Data Source
  KAKENHI-PROJECT-23592022
[Presentation] Modification of IL-12p70/Osteopontin balance in dendritic cells by ligand activation of invariant NKT cells2012
- Author(s)
  Motoharu Suzuki, Tianyi Liu, Narumi Hirosawa, Yayoi Nobori, Ayako Okamura, Yasushi Sakamoto, Kiyotaka Kuzushima, and Yasushi Uemura
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌市
- Data Source
  KAKENHI-PROJECT-23592022
[Presentation] Regulation of IL-27/Osteopontin balance in dendritic cells by ligand activation of invariant NKT cells2012
- Author(s)
  Rong Zhang, Tianyi Liu, Motoharu Suzuki, Narumi Hirosawa, Shin Kaneko, Ayako Okamura, Yasushi Sakamoto, Kiyotaka Kuzushima, and Yasushi Uemura
- Organizer
  第41回日本免疫学会学術集会
- Place of Presentation
  神戸市
- Data Source
  KAKENHI-PROJECT-23592022
[Presentation] 人工抗原提示細胞システムを利用した新規腫瘍抗原探索2012
- Author(s)
  岡村文子
- Organizer
  第34回日本造血細胞移植学会総会
- Place of Presentation
  大阪、大阪国際会議場
- Year and Date
  2012-02-24
- Data Source
  KAKENHI-PROJECT-23701079
[Presentation] 人工抗原提示細胞システムを利用した新規腫瘍抗原探索2012
- Author(s)
  岡村文子
- Organizer
  第34回日本造血細胞移植学会総会(招待講演)
- Place of Presentation
  大阪国際会議場
- Data Source
  KAKENHI-PROJECT-23701079
[Presentation] 内因性HLAの発現を抑制し目的のHLA-A24を発現する人工抗原提示細胞を用いた卵巣がんを傷害するCTLの誘導2011
- Author(s)
  近藤紳司, 岡村文子, 牧寛之, Zhang Rong ,植村靖史, 藤田貢, 山本英子, 柴田清住, 吉川史隆, 葛島清隆
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  愛知県名古屋市
- Data Source
  KAKENHI-PROJECT-23592022
[Presentation] 膵がん細胞における恒常的高活性オートファジーによるCTLエピトープの産生2011
- Author(s)
  岡村文子
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋、名古屋国際会議場
- Year and Date
  2011-10-05
- Data Source
  KAKENHI-PROJECT-23701079
[Presentation] Constitutively active autophagy causes CTL epitope generation in pancreatic cancer cells2011
- Author(s)
  岡村文子
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場
- Data Source
  KAKENHI-PROJECT-23701079
[Presentation] 内因性HLAの発現を抑制し目的のHLA-A24を発現する人工抗原提示細胞を用いた卵巣癌を傷害するCTLの誘導2011
- Author(s)
  近藤紳司, 岡村文子, 牧寛之, Zhang Rong, 植村靖史, 藤田貢, 山本英子, 柴田清住, 吉川史隆, 葛島清隆
- Organizer
  第15回日本がん免疫学会総会
- Place of Presentation
  大阪府豊中市
- Data Source
  KAKENHI-PROJECT-23592022
[Presentation] K-rasの活性化変異に伴う高活性オートファジーによるCTLエピトープの産生
- Author(s)
  岡村文子、葛島清隆
- Organizer
  造血器腫瘍免疫療法研究会
- Place of Presentation
  ウインク愛知（名古屋市）
- Data Source
  KAKENHI-PROJECT-25871227

1. KUZUSHIMA Kiyotaka (30311442)

# of Collaborated Projects: 2 results

# of Collaborated Products: 12 results
2. UEMURA Yasushi (40364781)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
3. SENJU Satoru (50274709)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
4. OHTA RIEKO (30452460)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. Yamaguchi Rui (90380675)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. 今井優樹 (30440936)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 松下博和 (80597782)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. 吉田亮 (70401263)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 太田元規 (40290895)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 赤塚美樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 坂田征士

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 鈴木史朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

OKAMURA Ayako 岡村 文子

出町文子

Research Projects

Research Products

Co-Researchers

Analysis on T cells that are specific for MR1-restricted targets derived from tumorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of protein design methods for T cell receptors with immune single cell sequencing data analysis

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of CTL epitopes specific for autophagy-activated pancreatic cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Affinity maturation of cancer-specific TCRs by in vitro cell display methods and their application to drug discovery.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of immunotherapy targeting an epitope generated through autophagy.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of antigen presentation mediated with constitutively active autophagy that induced by K-ras mutationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

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Invariant NKT cell-based effector T cell expressing a tumor reactive T cell receptor, as a possible cell medicine for pancreatic cancer

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Identification of CTL epitope using mass spectrometer.Principal Investigator

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[Book] がん免疫療法の個別化を支える新・腫瘍免疫学2019

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[Book] 臨床免疫・アレルギー科2014

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[Journal Article] New evaluation of the tumor immune microenvironment of non-small cell lung cancer and its association with prognosis2022

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[Journal Article] Identification of neoantigens and development of antigen-specific immunotherapy2020

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[Journal Article] Improving TCR affinity on 293T cells2019

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OKAMURA Ayako 岡村文子