Yagyu Shigeki 柳生茂希

… Alternative Names

YAGYU Shigeki 柳生茂希

Less

Researcher Number	10572547
Other IDs
Affiliation (Current)	2025: 信州大学, 学術研究・産学官連携推進機構, 教授(特定雇用) 2025: 京都府立医科大学, 医学(系)研究科(研究院), 助教
Affiliation (based on the past Project Information) *help	2016 – 2024: 京都府立医科大学, 医学(系)研究科(研究院), 助教 2023: 信州大学, 学術研究・産学官連携推進機構, 教授(特定雇用) 2020: 京都府立医科大学, 医学(系)研究科(研究院), 学内講師 2010 – 2012: 京都府立医科大学, 医学研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / Pediatrics / Tumor therapeutics Except Principal Investigator Basic Section 52050:Embryonic medicine and pediatrics-related / Pediatrics / Basic Section 50020:Tumor diagnostics and therapeutics-related
Keywords	Principal Investigator 免疫疲弊 / CAR-T細胞 / 神経芽腫 / 固形腫瘍 / 遺伝子改変T細胞 / EPHB4 / NOTCH / 再発 / antigen loss / EPHA2 … More / オフターゲット / 腫瘍微小環境 / 小児がん / 細胞療法 / キメラ抗原受容体T細胞 / ピギーバックトランスポゾン / ヒギーバックトランスポゾン / 横紋筋肉腫 / BMI1 / がん幹細胞 / Notch / phox2b … More Except Principal Investigator 横紋筋肉腫 / 小児がん / CAR-T療法 / CD19 / CAR-T細胞療法 / 神経芽腫 / 腫瘍溶解性ウイルス / CAR-T / 腫瘍溶解性アデノウイルス / FLT3 / ピギーバックトランスポゾンベクター / 急性リンパ性白血病 / KMT2A再構成 / エクソソーム / CAR-T細胞 / 小児腫瘍 / PAX3-FOXO1 / Myostatin / 間葉系間質細胞 / 乳児 / JAK阻害剤 / miRNA / 分化 / T-reg / 制御性T細胞 / エフェクターサイトカイン / プロモーター制御 / 患者腫瘍組織移植モデル / 鶏卵漿尿膜法 / 鶏卵漿尿膜 / CAMアッセイ / 遺伝子改変アデノウイルスベクター / 遺伝子改変T細胞 / ドラッグデリバリー / 間葉系幹細胞 / siRNA / 融合遺伝子 / ヒギーバックトランスポゾン / 免疫疲弊 / プレシジョン医療 / RAS / MEK阻害剤 / RAS変異 / RAF-MEK阻害剤 / アポトーシス / HDAC阻害剤 / チェックポイント阻害剤 / 抗PD-1抗体 / B7-H3 / 免疫療法 / PD-L1 / 腫瘍マーカー / 髄液 / 血清 / liquid biopsy / microRNA Less

Development of gene cell therapy using mesenchymal stromal cells for neuroblastoma
- Principal Investigator
  
  家原知子
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Kyoto Prefectural University of Medicine
抗原陰性再発の克服を目指した多重特異性CAR-T細胞の開発Principal Investigator
- Principal Investigator
  
  柳生茂希
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Shinshu University
Development of novel gene therapy for rhabdomyosarcoma
- Principal Investigator
  
  菊地顕
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Kyoto Prefectural University of Medicine
The development of CAR-T therapy targeting FLT3 and CD19 for infant acute lymphoblastic leukemia
- Principal Investigator
  
  大曽根眞也
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Kyoto Prefectural University of Medicine
Development of combinatorial CAR-T cell therapy improving immunosupressive tumor microenvironmentPrincipal Investigator
- Principal Investigator
  
  Yagyu Shigeki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Kyoto Prefectural University of Medicine
Gene and cell therapy combining CD19-expressing adenovirus and CD19 CAR-T cells
- Principal Investigator
  
  Yoshida Hideki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Kyoto Prefectural University of Medicine
In ovo chorioallantoic membrane assay as a xenograft model for pediatric rhabdomyosarcoma
- Principal Investigator
  
  Kikuchi Ken
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Kyoto Prefectural University of Medicine
Development of CAR-T cell therapy complementary system for rhabdomyosarcoma using oncolytic virus
- Principal Investigator
  
  Hosoi Hajime
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Kyoto Prefectural University of Medicine
Examination of novel prognostic markers related to spontaneous regression and differentiation of neuroblastoma
- Principal Investigator
  
  Iehara Tomoko
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Kyoto Prefectural University of Medicine
Development of CAR-T cell therapy for KMT2A-rearranged acute lymphoblastic leukemia
- Principal Investigator
  
  Osone Shinya
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Kyoto Prefectural University of Medicine
Study of specific gene expression in intractable childhood cancer and growth suppression and differentiation inducing effect of HDAC inhibitors
- Principal Investigator
  
  Iehara Tomoko
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Kyoto Prefectural University of Medicine
Mutations in the RAS Pathway as Potential Precision Medicine Targets in Treatment of Rhabdomyosarcoma
- Principal Investigator
  
  Kikuchi Ken
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Kyoto Prefectural University of Medicine
A novel cell and gene therapy for human rhabdomyosarcoma using exosome delivery system
- Principal Investigator
  
  Hosoi Hajime
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  Kyoto Prefectural University of Medicine
Development of chimeric antigen receptor T cells redirecting a growth factor receptor on human rhabdomyosarcomaPrincipal Investigator
- Principal Investigator
  
  Yagyu Shigeki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Kyoto Prefectural University of Medicine
Development of new treatment strategy for rhabdomyosarcoma using serum and cerebrospinal fluid microRNA
- Principal Investigator
  
  Miyachi Mitsuru
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Kyoto Prefectural University of Medicine
Elucidation of tumor immunity mechanism for clinical application of anti-PD1 antibody in childhood cancer
- Principal Investigator
  
  Tsuchiya Kunihiko
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Kyoto Prefectural University of Medicine
神経芽腫がん幹細胞の幹細胞特性維持と分化障害の分子機構解明Principal Investigator
- Principal Investigator
  
  柳生茂希
- Project Period (FY)
  2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pediatrics
- Research Institution
  Kyoto Prefectural University of Medicine
Sustained activation of phox2b gene affects on differentiation arrest of neuroblastomaPrincipal Investigator
- Principal Investigator
  
  YAGYU Shigeki
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pediatrics
- Research Institution
  Kyoto Prefectural University of Medicine

[Book] 炎症と免疫 vol.31no.4 5.【細胞医薬という新しい創薬モダリティ】固形腫瘍に対するCAR-T細胞療法2023
- Author(s)
  柳生茂希
- Total Pages
  91
- Publisher
  先端医学社
- ISBN
  4865506004
- Data Source
  KAKENHI-PROJECT-23K06692
[Book] 腫瘍内科 31(3) 新しいがん免疫療法研究の展開と臨床応用】臨床開発ステージに進んだ新たながん免疫療法非ウイルスベクター遺伝子導入によるCAR-T細胞療法2023
- Author(s)
  柳生茂希
- Total Pages
  124
- Publisher
  科学評論社
- Data Source
  KAKENHI-PROJECT-23K06692
[Book] 医学のあゆみ　285巻5号【mRNAワクチンやゲノム編集で注目が集まる遺伝子治療】実用化に向けた遺伝子治療技術がんに対するCAR-T細胞療法2023
- Author(s)
  柳生茂希
- Total Pages
  216
- Publisher
  医歯薬出版
- Data Source
  KAKENHI-PROJECT-23K06692
[Book] 医学のあゆみ 288(3) 【CAR-T細胞療法の最前線-現状と残された課題】非ウイルス遺伝子改変CAR-T細胞の開発動向2023
- Author(s)
  柳生茂希
- Total Pages
  70
- Publisher
  医歯薬出版
- Data Source
  KAKENHI-PROJECT-23K06692
[Journal Article] 【CAR-T細胞療法の最前線-現状と残された課題】非ウイルス遺伝子改変CAR-T細胞の開発動向2024
- Author(s)
  柳生茂希
- Journal Title
  
  医学のあゆみ
  
  Volume: 288 Pages: 205-210
- Data Source
  KAKENHI-PROJECT-22K07825
[Journal Article] 【mRNAワクチンやゲノム編集で注目が集まる遺伝子治療】がんに対するCAR-T細胞療法2023
- Author(s)
  柳生茂希，中沢洋三
- Journal Title
  
  医学のあゆみ
  
  Volume: 285 Pages: 119-130
- Data Source
  KAKENHI-PROJECT-22K07825
[Journal Article] 【細胞医薬という新しい創薬モダリティ】固形腫瘍に対するCAR-T細胞療法2023
- Author(s)
  柳生茂希
- Journal Title
  
  炎症と免疫
  
  Volume: 31 Pages: 289-293
- Data Source
  KAKENHI-PROJECT-22K07825
[Journal Article] 『がん治療における分子標的:その課題と未来展望』　小児がんに対する遺伝子改変細胞療法: 基礎開発から臨床応用までの道程2023
- Author(s)
  柳生茂希，家原知子
- Journal Title
  
  京都府立医科大学雑誌
  
  Volume: 132 Pages: 119-130
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K07825
[Journal Article] ASH-JSH joint symposium CAR-T therapy from the bench to the clinic and backピギーバックトランスポゾンを用いたメモリー機能の高いCAR-T細胞の作製2023
- Author(s)
  柳生茂希
- Journal Title
  
  臨床血液
  
  Volume: 64 Pages: 58-58
- Data Source
  KAKENHI-PROJECT-22K07825
[Journal Article] Engineering memory-rich CAR-T cells by a piggyBac transposon system2023
- Author(s)
  柳生茂希
- Journal Title
  
  Rinsho Ketsueki
  
  Volume: 64 Issue: 5 Pages: 418-426
- DOI
  10.11406/rinketsu.64.418
- ISSN
  0485-1439, 1882-0824
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K07825
[Journal Article] Ligand-based, piggyBac-engineered CAR-T cells targeting EGFR are safe and effective against non-small cell lung cancers2023
- Author(s)
  Thanyavi Chinsuwan, Koichi Hirabayashi, Shuji Mishima, Aiko Hasegawa, Miyuki Tanaka, Hidemi Mochizuki, Akihito Shimoi, Takashi Murakami, Shigeki Yagyu, Kimihiro Shimizu, Yozo Nakazawa
- Journal Title
  
  Molecular Therapy - Oncolytics
  
  Volume: 31 Pages: 1-14
- DOI
  10.1016/j.omto.2023.100728
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K15861, KAKENHI-PROJECT-22K07825, KAKENHI-PROJECT-22K08437, KAKENHI-PROJECT-23K06692
[Journal Article] piggyBac-transposon-mediated CAR-T cells for the treatment of hematological and solid malignancies2023
- Author(s)
  Yagyu Shigeki、Nakazawa Yozo
- Journal Title
  
  International Journal of Clinical Oncology
  
  Volume: - Issue: 6 Pages: 736-747
- DOI
  10.1007/s10147-023-02319-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07641, KAKENHI-PROJECT-22K07825, KAKENHI-PROJECT-23K06692
[Journal Article] 【mRNAワクチンやゲノム編集で注目が集まる遺伝子治療】実用化に向けた遺伝子治療技術がんに対するCAR-T細胞療法2023
- Author(s)
  柳生茂希、中沢洋三
- Journal Title
  
  医学のあゆみ
  
  Volume: 285 Pages: 363-369
- Data Source
  KAKENHI-PROJECT-22K07825
[Journal Article] In?ovo chorioallantoic membrane assay as a xenograft model for pediatric rhabdomyosarcoma2023
- Author(s)
 Shoji Chika、Kikuchi Ken、Yoshida Hideki、Miyachi Mitsuru、Yagyu Shigeki、Tsuchiya Kunihiko、Nakaya Takaaki、Hosoi Hajime、Iehara Tomoko
- Journal Title
 
 Oncology Reports
 
 Volume: 49 Issue: 4
- DOI
 10.3892/or.2023.8513
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-20K08187
[Journal Article] 【小児医療の最先端】臨床編　小児がんに対するCAR-T細胞療法2022
- Author(s)
  柳生茂希，中沢洋三
- Journal Title
  
  医学のあゆみ
  
  Volume: 282 Pages: 429-434
- Data Source
  KAKENHI-PROJECT-22K07825
[Journal Article] Targeting FLT3-specific chimeric antigen receptor T cells for acute lymphoblastic leukemia with KMT2A rearrangement2022
- Author(s)
  Suematsu Masaya、Yagyu Shigeki、Yoshida Hideki、Osone Shinya、Nakazawa Yozo、Sugita Kanji、Imamura Toshihiko、Iehara Tomoko
- Journal Title
  
  Cancer Immunology, Immunotherapy
  
  Volume: 72 Issue: 4 Pages: 957-968
- DOI
  10.1007/s00262-022-03303-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07825, KAKENHI-PROJECT-20K07641
[Journal Article] PiggyBac Transposon-Mediated CD19 Chimeric Antigen Receptor-T Cells Derived From CD45RA-Positive Peripheral Blood Mononuclear Cells Possess Potent and Sustained Antileukemic Function2022
- Author(s)
  Suematsu Masaya、Yagyu Shigeki、Nagao Nobuyoshi、Kubota Susumu、Shimizu Yuto、Tanaka Miyuki、Nakazawa Yozo、Imamura Toshihiko
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 13 Pages: 1-13
- DOI
  10.3389/fimmu.2022.770132
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08326, KAKENHI-PROJECT-22K07825, KAKENHI-PROJECT-20K07641
[Journal Article] The histone deacetylase inhibitor OBP‐801 has in?vitro / in?vivo anti‐neuroblastoma activity2022
- Author(s)
 Kaneda Daisuke、Iehara Tomoko、Kikuchi Ken、Sugimoto Yohei、Nakagawa Norio、Yagyu Shigeki、Miyachi Mitsuru、Konishi Eiichi、Sakai Toshiyuki、Hosoi Hajime
- Journal Title
 
 Pediatrics International
 
 Volume: 64 Issue: 1 Pages: 15159-15166
- DOI
 10.1111/ped.15159
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-20K08212
[Journal Article] 【小児医療の最先端】臨床編　小児がんに対するCAR-T細胞療法2022
- Author(s)
  柳生茂希、中沢洋三
- Journal Title
  
  医学のあゆみ
  
  Volume: 282 Pages: 429-434
- Data Source
  KAKENHI-PROJECT-20K07641
[Journal Article] Non-viral inducible caspase 9 mRNA delivery using lipid nanoparticles against breast cancer: An in-vitro study2022
- Author(s)
  Nakashima Ikumi、Saito Shoji、Akahoshi Eiichi、Yagyu Shigeki、Sugano-Ishihara Mitsuko、Nakazawa Yozo
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 635 Pages: 144-153
- DOI
  10.1016/j.bbrc.2022.09.105
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07641, KAKENHI-PROJECT-20K08227
[Journal Article] Lymphodepleted non-human primate model for the assessment of acute on-target and off-tumor toxicity of human CAR-T cells.2021
- Author(s)
  Yagyu S, Mochizuki H, Yamashima K, Kubo H, Saito S, Tanaka M, Sakamoto K, Shimoi A, Nakazawa Y.
- Journal Title
  
  Clinical & Translational Immunology
  
  Volume: -
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08326
[Journal Article] ピギーバックトランスポゾンを用いた遺伝子改変キメラ抗原受容体T細胞の開発2021
- Author(s)
  柳生茂希，中沢洋三
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: 75 Pages: 515-520
- Data Source
  KAKENHI-PROJECT-19K08326
[Journal Article] A lymphodepleted non‐human primate model for the assessment of acute on‐target and off‐tumor toxicity of human chimeric antigen receptor‐T cells2021
- Author(s)
  Yagyu Shigeki、Mochizuki Hidemi、Yamashima Kumiko、Kubo Hiroshi、Saito Shoji、Tanaka Miyuki、Sakamoto Kengo、Shimoi Akihito、Nakazawa Yozo
- Journal Title
  
  Clinical Translational Immunology
  
  Volume: 10 Issue: 6 Pages: 1291-1291
- DOI
  10.1002/cti2.1291
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08326, KAKENHI-PROJECT-20K07641
[Journal Article] Development of non-viral, ligand-dependent, EPHB4-specific chimeric antigen receptor T cells for treatment of rhabdomyosarcoma.2021
- Author(s)
  Kubo H, Yagyu S, Nakamura K, Yamashima K, Tomida A, Kikuchi K, Iehara T, Nakazawa Y, Hosoi H.
- Journal Title
  
  Molecular Therapy - Oncolytics
  
  Volume: 20 Pages: 646-658
- DOI
  10.1016/j.omto.2021.03.001
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08326, KAKENHI-PROJECT-20K07641
[Journal Article] Inhibition of MEK pathway enhances the antitumor efficacy of chimeric antigen receptor T cells against neuroblastoma2021
- Author(s)
  Tomida Akimasa、Yagyu Shigeki、Nakamura Kayoko、Kubo Hiroshi、Yamashima Kumiko、Nakazawa Yozo、Hosoi Hajime、Iehara Tomoko
- Journal Title
  
  Cancer Science
  
  Volume: 112 Issue: 10 Pages: 4026-4036
- DOI
  10.1111/cas.15074
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08326, KAKENHI-PROJECT-20K07641
[Journal Article] Mutated GM-CSF-based CAR T-cells targeting CD116/CD131 complexes exhibit enhanced anti-tumor effects against AML.2021
- Author(s)
  Hasegawa A, Saito A, Narimatsu S, Nakano S, Nagai M, Ohnota H, Inada Y, Morokawa H, Nakashima I, Morita D, Ide Y, Matsuda K, Tashiro H, Yagyu S, Tanaka M, Nakazawa Y.
- Journal Title
  
  Clinical & Translational Immunology
  
  Volume: -
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08326
[Journal Article] Autologous antigen-presenting cells efficiently expand piggyBac transposon chimeric antigen receptor T cells with predominant memory phenotype.2021
- Author(s)
  Nakamura K, Yagyu S, Hirota S, Tomida A, Kondo M, Shigeura T, Hasegawa A, Tanaka M, Nakazawa Y.
- Journal Title
  
  Molecular Therapy - Methods and Clinical Development
  
  Volume: 21 Pages: 315-324
- DOI
  10.1016/j.omtm.2021.03.011
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08326, KAKENHI-PROJECT-20K07641
[Journal Article] Autologous non-human primate model for safety assessment of piggyBac transposon-mediated chimeric antigen receptor T cells on granulocyte-macrophage colony-stimulating factor receptor.2020
- Author(s)
  Morokawa H, Yagyu S, Hasegawa A, Tanaka M, Saito S, Mochizuki H, Sakamoto K, Shimoi A, Nakazawa Y.
- Journal Title
  
  Clinical & Translational Immunology
  
  Volume: 22 Issue: 11
- DOI
  10.1002/cti2.1207
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08326, KAKENHI-PROJECT-20K07641, KAKENHI-PROJECT-20K08227
[Journal Article] Development and clinical application of chimeric antigen receptor T cell therapy for pediatric solid tumors2019
- Author(s)
  柳生茂希
- Journal Title
  
  The Japanese Journal of Pediatric Hematology / Oncology
  
  Volume: 56 Issue: 3 Pages: 304-310
- DOI
  10.11412/jspho.56.304
- NAID
  130007747186
- ISSN
  2187-011X, 2189-5384
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K07224
[Journal Article] 小児固形腫瘍に対する遺伝子改変T細胞療法の開発と臨床応用2019
- Author(s)
  柳生茂希
- Journal Title
  
  日本小児血液・がん学会雑誌
  
  Volume: 56 Pages: 304-310
- NAID
  130007747186
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H04230
[Journal Article] OBP-801, a novel histone deacetylase inhibitor, induces M phase arrest and apoptosis in rhabdomyosarcoma cells.2019
- Author(s)
  Tomoyasu C, Kikuchi K, Kaneda D, Yagyu S, Miyachi M, Tsuchiya K, Iehara T, Sakai T, Hosoi H.
- Journal Title
  
  Oncol Rep.
  
  Volume: 41 Pages: 643-649
- DOI
  10.3892/or.2019.6997
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04230
[Journal Article] OBP;801, a novel histone deacetylase inhibitor, induces M;phase arrest and apoptosis in rhabdomyosarcoma cells.2019
- Author(s)
  Tomoyasu C, Kikuchi K, Kaneda D, Yagyu S, Miyachi M, Tsuchiya K, Iehara T, Sakai T, Hosoi H
- Journal Title
  
  Oncol Rep
  
  Volume: 41(1) Pages: 643-649
- DOI
  10.3892/or.2018.6813
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10122
[Journal Article] Mutations in the RAS pathway as potential precision medicine targets in treatment of rhabdomyosarcoma.2019
- Author(s)
  Nakagawa N, Kikuchi K, Yagyu S, Miyachi M, Iehara T, Tajiri T, Sakai T, Hosoi H.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 512 Issue: 3 Pages: 524-530
- DOI
  10.1016/j.bbrc.2019.03.038
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10123, KAKENHI-PROJECT-17H04230, KAKENHI-PROJECT-19K09053, KAKENHI-PLANNED-17H06398, KAKENHI-PROJECT-19H01079, KAKENHI-PROJECT-19H03719, KAKENHI-PROJECT-17K11517, KAKENHI-PROJECT-17K11518
[Journal Article] Cellular and molecular characteristics of established neuroblastoma cell lines.2019
- Author(s)
  Tohru Sugimoto, Hiroshi Kuroda, Sigeki Yagyu, Takahiro Gotoh, Shinya Osone, Shinchi Tamura, Tomoko Iehara, Hajime Hosoi
- Journal Title
  
  Journal of Cancer Research and Therapeutic Oncology
  
  Volume: 7 Pages: 1-15
- DOI
  10.17303/jcrto.2019.7.201
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08326
[Journal Article] A MYCN-amplified cell line derived from a long-term event-free survivor among our sixteen established neuroblastoma cell lines.2012
- Author(s)
  Sugimoto T, Gotoh T, Yagyu S, et al.
- Journal Title
  
  Cancer Letters
  
  Volume: (pii:S0304-3835(12)00728-8.)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24791080
[Journal Article] Preoperative analysis of 11q loss using circulating tumor-released DNA in serum : a novel diagnostic tool for therapy stratification of neuroblastoma2011
- Author(s)
  Yagyu S, Iehara T, et al
- Journal Title
  
  Cancer Letters
  
  Volume: 309 Issue: 2 Pages: 185-189
- DOI
  10.1016/j.canlet.2011.05.032
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790994
[Journal Article] Preoperative analysis of 11q loss using circulating tumor-released DNA in serum : a novel diagnostic tool for therapy stratification of neuroblastoma2011
- Author(s)
  Yagyu S, et al
- Journal Title
  
  Cancer Lett
  
  Volume: 309 Pages: 185-189
- Data Source
  KAKENHI-PROJECT-22790994
[Journal Article] Detection of MYCN DNA in the cerebrospinal fluid for diagnosing isolated central nervous system relapse in neuroblastoma2011
- Author(s)
  Kimoto T, Yagyu S, et al
- Journal Title
  
  Pediatr Blood Cancer
  
  Volume: 56 Pages: 865-867
- Data Source
  KAKENHI-PROJECT-22790994
[Journal Article] Sensitivity of malignant rhabdoid tumor cell lines to PD 0332991 is inversely correlated with p16 expression2011
- Author(s)
  Katsumi Y, Yagyu S., et al
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 413 Pages: 62-68
- Data Source
  KAKENHI-PROJECT-22790994
[Journal Article] Circulating muscle-specific microRNA, miR-206, as a potential diagnostic marker for rhabdomyosarcoma2010
- Author(s)
  Miyachi M, Yagyu S, et al
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 400 Pages: 89-93
- Data Source
  KAKENHI-PROJECT-22790994
[Journal Article] Restoration of p53 pathway by nutlin-3 induces cell cycle arrest and apoptosis in human rhabdomyosarcoma cells2009
- Author(s)
  Miyachi M, Yagyu S, et al
- Journal Title
  
  Clin Cancer Res
  
  Volume: 15 Pages: 4077-4084
- Data Source
  KAKENHI-PROJECT-22790994
[Journal Article] RASSF1A hypermethylation in pretreatment serum DNA of neuroblastoma patients : a prognostic marker2009
- Author(s)
  Misawa A, Yagyu S, et al
- Journal Title
  
  Br J Cancer
  
  Volume: 100 Pages: 399-404
- Data Source
  KAKENHI-PROJECT-22790994
[Patent] ＣＡＲ発現免疫細胞を含む細胞集団の製造方法2020
- Inventor(s)
  柳生茂希ほか
- Industrial Property Rights Holder
  柳生茂希ほか
- Industrial Property Rights Type
  特許
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-20K07641
[Patent] ＣＡＲ発現免疫細胞を含む細胞集団の製造方法2019
- Inventor(s)
  柳生茂希、中沢洋三、田中美幸、中村加世子、ほか3名
- Industrial Property Rights Holder
  京都府公立大学法人、国立大学法人信州大学、ブライトパス・バイオ
- Industrial Property Rights Type
  特許
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-17K07224
[Patent] CAR発現免疫細胞を含む細胞集団の製造方法2019
- Inventor(s)
  柳生茂希
- Industrial Property Rights Holder
  京都府公立大学法人
- Industrial Property Rights Type
  特許
- Filing Date
  2019
- Overseas
- Data Source
  KAKENHI-PROJECT-17H04230
[Patent] 殺細胞効果を有するキメラ抗原受容体遺伝子改変リンパ球2017
- Inventor(s)
  柳生茂希、中沢洋三、家原知子、細井創
- Industrial Property Rights Holder
  京都府公立大学法人、国立大学法人信州大学
- Industrial Property Rights Type
  特許
- Filing Date
  2017
- Overseas
- Data Source
  KAKENHI-PROJECT-17K07224
[Presentation] Memory-rich CAR-T cell engineering by piggyBac transposon system for solid malignancies2024
- Author(s)
  Shigeki Yagyu
- Organizer
  American Society of Gene + Cell Therapy Virtual Events: Around the World: Innovation in Japan
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07825
[Presentation] Memory-rich CAR-T cell engineering by piggyBac transposon system for solid malignancies2023
- Author(s)
  Yagyu S
- Organizer
  The 60th Annual Congress of the Japanese Society of Pediatric Surgeons
- Invited
- Data Source
  KAKENHI-PROJECT-23K06692
[Presentation] CAR-T細胞療法の社会実装を目指したアカデミアとバイオテックの連携2023
- Author(s)
  柳生茂希
- Organizer
  日本遺伝子細胞治療学会学術集会シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-23K06692
[Presentation] 固形腫瘍に対する非ウイルス遺伝子改変CAR-T細胞療法の開発2023
- Author(s)
  柳生茂希
- Organizer
  第27回日本がん免疫学会
- Invited
- Data Source
  KAKENHI-PROJECT-23K06692
[Presentation] 非ウイルス遺伝子改変CAR-T細胞の開発と臨床応用　ーアカデミアでの基礎開発から臨床実装に向けた取り組み2023
- Author(s)
  柳生茂希
- Organizer
  第61回日本癌治療学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-23K06692
[Presentation] ピギーバックトランスポゾン法を用いたCAR-T細胞療法の開発と臨床応用2023
- Author(s)
  柳生茂希
- Organizer
  第29回日本遺伝子細胞治療学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-23K06692
[Presentation] 国内のCAR-T療法開発と実臨床の現状　固形腫瘍に対する非ウイルス遺伝子改変CAR-T細胞療法の開発2023
- Author(s)
  柳生茂希
- Organizer
  第27回日本がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-22K07825
[Presentation] CAR-T細胞療法の小児がんへの応用:白血病から固形腫瘍まで　固形腫瘍に対するCAR-T細胞療法の開発と臨床応用2023
- Author(s)
  柳生茂希
- Organizer
  第61回日本癌治療学会学術集会
- Data Source
  KAKENHI-PROJECT-22K07825
[Presentation] 小児がん研究最前線　小児固形腫瘍に対するピギーバックトランスポゾンCAR-T細胞療法の開発2023
- Author(s)
  柳生茂希
- Organizer
  第82回日本癌学会総会
- Data Source
  KAKENHI-PROJECT-22K07825
[Presentation] Memory-rich CAR-T cell engineering by piggyBac transposon system for solid malignancies2023
- Author(s)
  Yagyu S
- Organizer
  American Society of Gene and Cell Therapy Around the World: Innovation in Japan.
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K06692
[Presentation] 非ウイルス遺伝子改変CAR-T細胞の開発と臨床応用2023
- Author(s)
  柳生茂希
- Organizer
  第61回日本癌治療学会学術集会
- Data Source
  KAKENHI-PROJECT-22K07825
[Presentation] Memory-rich CAR-T cell engineering by piggyBac transposon system for solid malignancies2023
- Author(s)
  Yagyu S
- Organizer
  82nd JCA Annual Meeting 2023 Symposia on Specific Tumors
- Invited
- Data Source
  KAKENHI-PROJECT-23K06692
[Presentation] Memory-rich CAR-T cell engineering by piggyBac transposon system for solid malignancies2023
- Author(s)
  Yagyu S
- Organizer
  61st Annual Meeting of the Japan Society of Clinical Oncology Cross-cutting Workshop 3
- Invited
- Data Source
  KAKENHI-PROJECT-23K06692
[Presentation] Memory-rich CAR-T cell engineering by piggyBac transposon system for solid malignancies.2022
- Author(s)
  Yagyu S
- Organizer
  25th ASGCT 25TH ANNUAL MEETING
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07641
[Presentation] 固形腫瘍に対する非ウイルス遺伝子改変CAR-T細胞療法の開発2022
- Author(s)
  Yagyu S
- Organizer
  第28回日本遺伝子細胞治療学会　Young Investigators session; explore a new era of gene therapy research
- Invited
- Data Source
  KAKENHI-PROJECT-20K07641
[Presentation] 非ウイルス遺伝子改変CAR-T細胞 - アカデミアでの基礎開発から臨床実装に向けた取り組み2022
- Author(s)
  Yagyu S
- Organizer
  LINK-J 「ライフサイエンス都市柏の葉」で躍進するイノベーションシリーズvol.2
- Invited
- Data Source
  KAKENHI-PROJECT-20K07641
[Presentation] 非ウイルス遺伝子改変法による遺伝子改変キメラ抗原受容体T細胞療法の開発2022
- Author(s)
  Yagyu S
- Organizer
  日本核酸医薬学会第7回例会
- Invited
- Data Source
  KAKENHI-PROJECT-20K07641
[Presentation] Memory-rich CAR-T cell engineering by piggyBac transposon system for solid malignancies2022
- Author(s)
  Yagyu S
- Organizer
  第81回日本癌学会　シンポジウム21 ウイルス療法・免疫細胞治療の現在と未来
- Invited
- Data Source
  KAKENHI-PROJECT-20K07641
[Presentation] 非ヒト霊長類モデルによる遺伝子改変キメラ抗原受容体T細胞のオンターゲット毒性評価法の開発2022
- Author(s)
  Yagyu S
- Organizer
  第49回日本毒性学会学術集会　シンポジウム16　遺伝子・細胞治療薬開発とその安全性評価
- Invited
- Data Source
  KAKENHI-PROJECT-20K07641
[Presentation] piggyBac transposon-mediated CAR-T cells for solid tumors - A promising approach for clinical application2022
- Author(s)
  Yagyu S
- Organizer
  International Conference on Lymphocyte Engineering
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07641
[Presentation] Memory-rich CAR-T cell engineering by piggyBac transposon system for solid malignancies.2022
- Author(s)
  Yagyu S
- Organizer
  25th ASGCT 25TH ANNUAL MEETING “Cutting Edge Gene and Cell Therapy Research in Japan
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07641
[Presentation] CAR-T therapy from the bench to the clinic and back2022
- Author(s)
  Shigeki Yagyu
- Organizer
  第84回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-22K07825
[Presentation] 非ウイルス遺伝子改変法による遺伝子改変キメラ抗原受容体T細胞療法の開発と臨床応用2022
- Author(s)
  Yagyu S
- Organizer
  第14回日本血液疾患免疫療法学会　シンポジウム：がん免疫療法の新戦略
- Invited
- Data Source
  KAKENHI-PROJECT-20K07641
[Presentation] piggyBac transposon-mediated CAR-T cells for solid tumors - A promising approach for clinical application.2022
- Author(s)
  Yagyu S
- Organizer
  International Conference on Lymphocyte Engineering
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07641
[Presentation] Memory-rich CAR-T cell engineering by piggyBac transposon system for solid malignancies2022
- Author(s)
  Yagyu S
- Organizer
  第44回日本造血細胞・細胞療法学会シンポジウム New Horizons in the Cell and Gene Therapy
- Invited
- Data Source
  KAKENHI-PROJECT-20K07641
[Presentation] Memory-rich CAR-T cell engineering by piggyBac transposon system for solid malignancies.2022
- Author(s)
  柳生茂希
- Organizer
  第44回日本造血細胞・細胞療法学会
- Invited
- Data Source
  KAKENHI-PROJECT-20K07641
[Presentation] Lymphodepleted non-human primate model for the assessment of acute on-target and off-tumor toxicity of human CAR-T cells.2021
- Author(s)
  Yagyu S, et al.
- Organizer
  49th Annual Scientific Meeting of the Australian and New Zealand Society for Immunology, ASI 2021.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08326
[Presentation] Non-viral gene transfer based chimeric antigen receptor T cells for solid tumors - 悪性固形腫瘍に対するCAR-T細胞の開発 -2021
- Author(s)
  Yagyu S, et al.
- Organizer
  第27回日本遺伝子細胞治療学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-19K08326
[Presentation] Non-viral gene transfer based chimeric antigen receptor T cells for solid tumors.2021
- Author(s)
  柳生茂希
- Organizer
  第27回日本遺伝子細胞治療学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-20K07641
[Presentation] Non-viral gene transfer based chimeric antigen receptor T cells for solid tumors2021
- Author(s)
  柳生茂希
- Organizer
  第27回日本遺伝子細胞治療学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08326
[Presentation] Recent advances of CAR-T cell therapy for pediatric solid tumors.2021
- Author(s)
  Yagyu S, et al.
- Organizer
  Annual Meeting of Japanese Society of Pediatrics
- Data Source
  KAKENHI-PROJECT-19K08326
[Presentation] piggyBac transposon-mediated CAR-T cells for solid tumors - A promising approach for clinical application.2021
- Author(s)
  Yagyu S, et al.
- Organizer
  The 12th JSH International Symposium 2021 in Kamakura.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08326
[Presentation] Lymphodepleted non-human primate model for the assessment of acute on-target/off-tumor toxicity of human CAR-T cells.2021
- Author(s)
  Yagyu S
- Organizer
  49th Annual Scientific Meeting of the Australian and New Zealand Society for Immunology, ASI 2021
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07641
[Presentation] Development of multi-antigen specific chimeric antigen receptor T cells for acute lymphoblastic leukemia with rearrangement of KMT2A gene.2021
- Author(s)
  Suematsu M, Yagyu S, Osone S, et al.
- Organizer
  第63回日本小児血液・がん学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08326
[Presentation] 悪性固形腫瘍に対する非ウイルス遺伝子改変キメラ抗原受容体T細胞の開発2021
- Author(s)
  柳生茂希
- Organizer
  AMED再生・細胞医療・遺伝子治療研究開発交流会シンポジウム
- Data Source
  KAKENHI-PROJECT-19K08326
[Presentation] PiggyBac transposon mediated CD19 CAR-T cells derived from CD45RA-positive PBMCs possess potent and sustained antileukemic function.2021
- Author(s)
  Suematsu M, Yagyu S, et al.
- Organizer
  64th Annual meeting of American Society of Hematology.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08326
[Presentation] piggyBac transposon-mediated CAR-T cells for solid tumors - A promising approach for clinical application.2021
- Author(s)
  Yagyu S
- Organizer
  The 12th JSH International Symposium 2021 in Kamakura
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07641
[Presentation] piggyBac transposon mediated CAR-T cells for solid tumor - A promising and realistic approach for clinical application.2020
- Author(s)
  Yagyu S
- Organizer
  第79回日本癌学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08326
[Presentation] Combination therapy of GD2-specific CAR-T cell with Tyrosine Kinase inhibitor for neuroblastoma cells.2020
- Author(s)
  Tomida A, Yagyu S, Yamashima K, Kubo H, Iehara T, Nakazawa Y, Hosoi H.
- Organizer
  23rd Annual Meeting of American Society of Gene and Cell Therapy.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08326
[Presentation] piggyBac transposon-mediated CAR-T cells - A promising and realistic approach for clinical application.2020
- Author(s)
  Yagyu S
- Organizer
  International Society of Cell Therapy 2020 Virtual.
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07641
[Presentation] 固形腫瘍を標的とした非ウイルス遺伝子改変CAR-T細胞の開発2020
- Author(s)
  柳生茂希
- Organizer
  第4回WAKO Web受託セミナー
- Data Source
  KAKENHI-PROJECT-19K08326
[Presentation] piggyBac transposon mediated CAR-T cells for solid tumor - A promising and realistic approach for clinical application.2020
- Author(s)
  Yagyu S
- Organizer
  第79回日本癌学会学術集会
- Data Source
  KAKENHI-PROJECT-20K07641
[Presentation] piggyBac transposon-mediated CAR-T cells - A promising and realistic approach for clinical application.2020
- Author(s)
  Yagyu S
- Organizer
  International Society of Cell Therapy 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08326
[Presentation] リアルタイム細胞アナライザーを用いた遺伝子改変キメラ抗原受容体T細胞の機能解析2020
- Author(s)
  柳生茂希
- Organizer
  Agilentオンライン細胞解析セミナー2020
- Data Source
  KAKENHI-PROJECT-19K08326
[Presentation] Recent advances of CAR-T cell therapy for pediatric solid tumors.2020
- Author(s)
  Yagyu S
- Organizer
  第62回日本小児血液・がん学会学術集会
- Data Source
  KAKENHI-PROJECT-20K07641
[Presentation] Development and clinical application of chimeric antigen receptor T cell therapy for pediatric solid tumors.2019
- Author(s)
  Yagyu S
- Organizer
  第61回日本小児血液・がん学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-17H04230
[Presentation] Optimization of PiggyBac Transposon-Based Gene Delivery by the MaxCyte Scalable Transfection System for Manufacturing Chimeric Antigen Receptor-T Cells．2019
- Author(s)
  Tomida A, Yagyu S, Yamashima K, Kubo H, Iehara T, Nakazawa Y, Hosoi H.
- Organizer
  22nd Annual Meeting of American Society of Gene and Cell Therapy
- Data Source
  KAKENHI-PROJECT-17H04230
[Presentation] トランスポゾン法で作成したGD2特異的CART細胞は神経芽腫細胞に対して抗腫瘍効果を示す．Development of piggyBac Transposon-Mediated GD2 specific CAR-T Cells targeting Neuroblastoma.2019
- Author(s)
  9.Tomida A, Yagyu S, Yamashima K, Yoshida H, Miyachi M, Tsuchiya K, Iehara T, Nakazawa Y, Hosoi H.
- Organizer
  第61回日本小児血液・がん学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-17K07224
[Presentation] Development of piggyBac transposon based CAR-T cell therapy; Driving CARs to the clinic for solid Tumors.2019
- Author(s)
  Yagyu S
- Organizer
  第25回日本遺伝子細胞治療学会
- Invited
- Data Source
  KAKENHI-PROJECT-17H04230
[Presentation] 小児固形腫瘍に対する遺伝子改変T細胞療法の開発と臨床応用 - Driving CARs to the clinic for solid tumors．2019
- Author(s)
  柳生茂希
- Organizer
  大阪小児固形腫瘍研究会
- Invited
- Data Source
  KAKENHI-PROJECT-17K07224
[Presentation] Development of PiggyBac Transposon Mediated CAR-T Cells Targeting EPHB4 for Pediatric Solid Tumors．2019
- Author(s)
  Yagyu S, Tomida A, Kubo H, Yamashima K, Kikuchi K, Nakamura K, Tanaka M, Nakazawa Y, Iehara T, Hosoi H.
- Organizer
  51st Annual Congress of the International Society of Paediatric Oncology
- Data Source
  KAKENHI-PROJECT-17H04230
[Presentation] 霊長類モデルを用いた遺伝子改変T細胞療法の安全性評価系の開発．2019
- Author(s)
  柳生茂希
- Organizer
  第7回浜松毒性フォーラム
- Invited
- Data Source
  KAKENHI-PROJECT-17H04230
[Presentation] トランスポゾン法で作成したGD2特異的CART細胞は神経芽腫細胞に対して抗腫瘍効果を示す．Development of piggyBac Transposon-Mediated GD2 specific CAR-T Cells targeting Neuroblastoma.2019
- Author(s)
  Tomida A, Yagyu S, Yamashima K, Yoshida H, Miyachi M, Tsuchiya K, Iehara T, Nakazawa Y, Hosoi H.
- Organizer
  第61回日本小児血液・がん学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-17H04230
[Presentation] Development and clinical application of chimeric antigen receptor T cell therapy for pediatric solid tumors.2019
- Author(s)
  Yagyu S
- Organizer
  第61回日本小児血液・がん学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-17K07224
[Presentation] Development of PiggyBac Transposon Mediated CAR-T Cells Targeting EPHB4 for Pediatric Solid Tumors．2019
- Author(s)
  Yagyu S, Tomida A, Kubo H, Yamashima K, Kikuchi K, Nakamura K, Tanaka M, Nakazawa Y, Iehara T, Hosoi H.
- Organizer
  51st Annual Congress of the International Society of Paediatric Oncology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07224
[Presentation] 霊長類モデルを用いたpiggyBacトランスポゾン遺伝子改変GMR CAR-細胞の安全性評価.2019
- Author(s)
  Morokawa H, Tanaka M, Saito S, Mochizuki H, Shimoi A, Yagyu S, Nakazawa Y.
- Organizer
  第61回日本小児血液・がん学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-17H04230
[Presentation] Development of piggyBac transposon based CAR-T cell therapy; Driving CARs to the clinic for solid Tumors.2019
- Author(s)
  Yagyu S
- Organizer
  第25回日本遺伝子細胞治療学会
- Invited
- Data Source
  KAKENHI-PROJECT-17K07224
[Presentation] 小児がん拠点病院である当院における終末期在宅医療の現状2019
- Author(s)
  宮地　充，柳生茂希，大曽根眞也，土屋邦彦，今村俊彦，家原知子，細井　創
- Organizer
  第57回日本癌治療学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08326
[Presentation] Development of chimeric antigen receptor T cell therapy for human rhabdomypsarcoma.2019
- Author(s)
  Yagyu S, Morita D, Tanaka M, Kikuchi K, Iehara T, Nakazawa Y, Hosoi H
- Organizer
  The 2nd International Cancer Research Symposium of Training Plan for Oncology Professionals.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04230
[Presentation] 霊長類モデルを用いたpiggyBacトランスポゾン遺伝子改変GMR CAR-細胞の安全性評価.2019
- Author(s)
  Morokawa H, Tanaka M, Saito S, Mochizuki H, Shimoi A, Yagyu S, Nakazawa Y.
- Organizer
  第61回日本小児血液・がん学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-17K07224
[Presentation] 霊長類モデルを用いた遺伝子改変T細胞療法の安全性評価系の開発．2019
- Author(s)
  柳生茂希
- Organizer
  第7回浜松毒性フォーラム
- Invited
- Data Source
  KAKENHI-PROJECT-17K07224
[Presentation] Optimization of PiggyBac Transposon-Based Gene Delivery by the MaxCyte Scalable Transfection System for Manufacturing Chimeric Antigen Receptor-T Cells．2019
- Author(s)
  Tomida A, Yagyu S, Yamashima K, Kubo H, Iehara T, Nakazawa Y, Hosoi H.
- Organizer
  22nd Annual Meeting of American Society of Gene and Cell Therapy
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07224
[Presentation] 小児固形腫瘍に対する遺伝子改変T細胞療法の開発と臨床応用 - Driving CARs to the clinic for solid tumors．2019
- Author(s)
  柳生茂希
- Organizer
  大阪小児固形腫瘍研究会
- Invited
- Data Source
  KAKENHI-PROJECT-17H04230
[Presentation] 横紋筋肉腫に対する新規 RAF/MEK デュアル阻害剤の検討2018
- Author(s)
  Nakagawa N, Kikuchi K, Yagyu S, Iehara T, Sakai T, Hosoi H.
- Organizer
  第60回日本小児血液・がん学会学術集会
- Data Source
  KAKENHI-PROJECT-17H04230
[Presentation] Development of piggyBac CAR-T cells - Experiences in Japan．2018
- Author(s)
  14.Yagyu S，Nakazawa Y
- Organizer
  6th piggyBac CART meeting, Houston, TX, USA, 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07224
[Presentation] Function, phenotype, and tonic signaling of GD2-CART cells using piggyBac transposon gene transfer.2018
- Author(s)
  Yagyu S，Nakamura K，Morita D，Tanaka M，Nakazawa Y.
- Organizer
  5th piggybac CART meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07224
[Presentation] The novel histone deacetylase inhibitor OBP-801 induces apoptosis in neuroblastoma tumor cells2018
- Author(s)
  Daisuke Kaneda, Ken Kikuchi, Kayoko Nakamura, Shigeki Yagyu, Tomoko Iehara, Toshiyuki Sakai, Hajime Hosoi
- Organizer
  Advances in NEうろbぁs苫Research
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10122
[Presentation] piggyBac transposon mediated chimeric antigen receptor T cell therapy for pediatric solid tumors.2018
- Author(s)
  10.Yagyu S.
- Organizer
  第60回日本小児血液・がん学会学術集会, 京都, 2018
- Data Source
  KAKENHI-PROJECT-17K07224
[Presentation] キメラ抗原受容体T細胞(CAR-T細胞)療法の開発と臨床応用2018
- Author(s)
  柳生茂希
- Organizer
  第３回日本遺伝子細胞治療学会研究会セミナー，東京，2018
- Data Source
  KAKENHI-PROJECT-17K07224
[Presentation] 横紋筋肉腫における新規ヒストン脱アセチル化酸素阻害剤OBP-801の抗腫瘍効果．2018
- Author(s)
  菊地顕，友安千紘，中村加世子，柳生茂希，宮地充，勝見良樹，土屋邦彦，家原知子，酒井敏行，細井　創
- Organizer
  第121回日本小児科学会学術集会
- Data Source
  KAKENHI-PROJECT-17H04230
[Presentation] Function, phenotype, and tonic signaling of GD2-CART cells using piggyBac transposon gene transfer．2018
- Author(s)
  Yagyu S，Nakamura K，Morita D，Tanaka M，Nakazawa Y.
- Organizer
  5th piggybac CART meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04230
[Presentation] The novel histone deacetylase inhibitor OBP-801 induces apoptosis in neuroblastoma tumor cells2018
- Author(s)
  Daisuke Kaneda, Ken Kikuchi, Kayoko Nakamura, Shigeki Yagyu, Tomoko Iehara, Toshiyuki Sakai, Hajime Hosoi
- Organizer
  Advances in Neuroblastoma research
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10122
[Presentation] 横紋筋肉腫における新規ヒストン脱アセチル化酸素阻害剤OBP-801の抗腫瘍効果2018
- Author(s)
  菊地顕，友安千紘，中村加世子，柳生茂希，宮地充，勝見良樹，土屋邦彦，家原知子，酒井敏行，細井　創
- Organizer
  第121回日本小児科学会学術集会
- Data Source
  KAKENHI-PROJECT-17K10122
[Presentation] 横紋筋肉腫における新規ヒストン脱メチル化酵素阻害剤の抗腫瘍効果と分子機構の解析2018
- Author(s)
  菊地顕、友安千紘、中村加世子、柳生茂希、宮地充、家原知子、酒井敏行、細井創
- Organizer
  第121回日本小児科学会学術集会
- Data Source
  KAKENHI-PROJECT-17K10122
[Presentation] Novel allosteric RAF/MEK inhibitor in the treatment of rhabdomyosarooma.2018
- Author(s)
  Nakagawa N, Kikuchi K, Yagyu S, Iehara T, Sakai T, Hosoi H.
- Organizer
  第60回日本小児血液・がん学会学術集会
- Data Source
  KAKENHI-PROJECT-17K10123
[Presentation] piggyBac transposon mediated chimeric antigen receptor T cell therapy for pediatric solid tumors.2018
- Author(s)
  15.Yagyu S，Nakamura K，Morita D，Tanaka M，Iehara T, Nakazawa Y, Hosoi H．
- Organizer
  0th Annual Meeting of American Society of Gene and Cell Therapy, Chicago, LA, USA, 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07224
[Presentation] CAR-T細胞療法と免疫逃避 - GD2-CAR-T細胞での検討-2017
- Author(s)
  柳生茂希，中村加世子.
- Organizer
  第5回信州CARTミーティング
- Data Source
  KAKENHI-PROJECT-17H04230
[Presentation] Chimeric Antigen Receptor T cells redirecting EPHB4 for the Treatment of Human Rhabdomyosarcoma．2017
- Author(s)
  Nakamura K，Yagyu S，Morita D，Kikuchi K，Iehara T，Hosoi H，Nakazawa Y．
- Organizer
  第2回日本遺伝子細胞治療学会若手研究会
- Data Source
  KAKENHI-PROJECT-17H04230
[Presentation] CAR-T細胞療法と免疫逃避 - GD2-CAR-T細胞での検討-2017
- Author(s)
  柳生茂希，中村加世子.
- Organizer
  第5回信州CARTミーティング
- Data Source
  KAKENHI-PROJECT-17K07224
[Presentation] Chimeric Antigen Receptor T cells redirecting EPHB4 for the Treatment of Human Rhabdomyosarcoma.2017
- Author(s)
  Nakamura K，Yagyu S，Morita D，Kikuchi K，Iehara T，Hosoi H，Nakazawa Y.
- Organizer
  第2回日本遺伝子細胞治療学会若手研究会
- Data Source
  KAKENHI-PROJECT-17K07224
[Presentation] Chimeric Antigen Receptor T cells redirecting EPHB4 for the Treatment of Human Rhabdomyosarcoma.2017
- Author(s)
  Yagyu S，Nakamura K，Morita D，Kikuchi K，Iehara T，Hosoi H，Nakazawa Y.
- Organizer
  第23回日本遺伝子細胞治療学会学術集会
- Data Source
  KAKENHI-PROJECT-17K07224
[Presentation] Mutation of Ras Pathway Should be a Target of Precision Medicine for Rhabdomyosarcoma2017
- Author(s)
  N. nakagawa, K. Kikuchi, K. Nakamura, T. Tanaka, S. Yagyu, T. Iehara, T. Tajiri, T. Sakai, H. Hosoi
- Organizer
  49th CONGRESS OF THE INTERNATIONAL SOCIETY OF PAEDIATRIC ONCOLOGY (SIOP)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10123
[Presentation] Chimeric Antigen Receptor T cells redirecting EPHB4 for the Treatment of Human Rhabdomyosarcoma．2017
- Author(s)
  Yagyu S，Nakamura K，Morita D，Kikuchi K，Iehara T，Hosoi H，Nakazawa Y．
- Organizer
  第23回日本遺伝子細胞治療学会学術集会
- Data Source
  KAKENHI-PROJECT-17H04230
[Presentation] Chimeric Antigen Receptor T cells redirecting EPHB4 for the Treatment of Human Rhabdomyosarcoma．2017
- Author(s)
  Yagyu S，Nakamura K，Morita D，Kikuchi K，Iehara T，Hosoi H，Nakazawa Y．
- Organizer
  第59回日本小児血液がん学会学術集会
- Data Source
  KAKENHI-PROJECT-17H04230
[Presentation] Chimeric Antigen Receptor T cells redirecting EPHB4 for the Treatment of Human Rhabdomyosarcoma2017
- Author(s)
  Yagyu S，Nakamura K，Morita D，Kikuchi K，Iehara T，Hosoi H，Nakazawa Y.
- Organizer
  第59回日本小児血液が学会学術集会
- Data Source
  KAKENHI-PROJECT-17K07224
[Presentation] 再発神経芽腫に対する治療戦略.当院における10年間の再発神経芽腫症例の検討2012
- Author(s)
  柳生茂希、家原知子, 他
- Organizer
  第54回日本小児血液がん学会学術集会
- Place of Presentation
  横浜
- Year and Date
  2012-12-02
- Data Source
  KAKENHI-PROJECT-24791080
[Presentation] Genomic Evolution in Relapsed Neuroblastoma2012
- Author(s)
  Yagyu S, Iehara T, et al.
- Organizer
  Advances in Neuroblastoma Research meeting
- Place of Presentation
  Toronto, Canada
- Year and Date
  2012-06-20
- Data Source
  KAKENHI-PROJECT-24791080
[Presentation] PROGNOSIS OF NEUROBLASTOMA PATIENTS LESS THAN EIGHTEEN MONTHS OLD USING SERUM-BASED QUANTIFICATION OF MYCN GENE AMPLIFICATION2011
- Author(s)
  Yagyu S, Iehara T, et al
- Organizer
  43rd Congress of the International Society of Pediatric Oncology
- Place of Presentation
  Auckland NZ
- Data Source
  KAKENHI-PROJECT-22790994
[Presentation] PROGNOSIS OF NEUROBLASTOMA PATIENTS LESS THAN EIGHTEEN MONTHS OLD USING SERUM-BASED QUANTIFICATION OF MYCN GENE AMPLIFICATION2011
- Author(s)
  Yagyu S et al
- Organizer
  43rd Congress of the International Society of Pediatric Oncology
- Place of Presentation
  Auckland, New Zealand
- Data Source
  KAKENHI-PROJECT-22790994
[Presentation] 初発時、再発時腫瘍を用いてゲノム異常解析を施行した中枢神経再発神経芽腫の3例2011
- Author(s)
  柳生茂希他
- Organizer
  第53回日本小児血液・がん学会学術集会
- Place of Presentation
  群馬
- Data Source
  KAKENHI-PROJECT-22790994
[Presentation] 髄液中PCR-MYCN増幅の検出が同種移植後中枢単独再発の確定診断に有用であった進行神経芽腫の1例2010
- Author(s)
  木本富子、柳生茂希他
- Organizer
  第26回日本小児がん学会学術集会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-22790994
[Presentation] MYCN非増幅にもかかわらず、著しい治療抵抗性を示した11qLOH陽性神経芽腫の1症例2010
- Author(s)
  吉田秀樹、柳生茂希他
- Organizer
  第26回日本小児がん学会学術集会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-22790994
[Presentation] 神経芽腫患者の血清中遊離DNAを用いた11番染色体長腕欠失の検出2010
- Author(s)
  柳生茂希, ほか
- Organizer
  第18回日本がん検診・診断学会総会
- Place of Presentation
  東京
- Year and Date
  2010-07-16
- Data Source
  KAKENHI-PROJECT-22790994
[Presentation] 神経芽腫患者の血清中遊離DNAを用いた11番染色体長腕欠失の検出2010
- Author(s)
  柳生茂希他
- Organizer
  第18回日本がん検診診断学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22790994
[Presentation] 血清中遊離DNAを用いた経時的MYCN遺伝子増幅定量が治療評価と経過観察に有効であった神経芽腫の6例2010
- Author(s)
  柳生茂希他
- Organizer
  第26回日本小児がん学会学術集会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-22790994
[Presentation] 神経芽腫患者の血清中遊離DNAを用いた11番染色体長腕欠失の検出2009
- Author(s)
  柳生茂希他
- Organizer
  第25回日本小児がん学会学術集会
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-22790994
[]

1. Kikuchi Ken (40453104)

# of Collaborated Projects: 13 results

# of Collaborated Products: 22 results
2. Iehara Tomoko (20285266)

# of Collaborated Projects: 11 results

# of Collaborated Products: 27 results
3. Miyachi Mitsuru (40584983)

# of Collaborated Projects: 8 results

# of Collaborated Products: 8 results
4. Hosoi Hajime (20238744)

# of Collaborated Projects: 8 results

# of Collaborated Products: 23 results
5. Yoshida Hideki (10643546)

# of Collaborated Projects: 7 results

# of Collaborated Products: 1 results
6. Tsuchiya Kunihiko (90381938)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
7. Osone Shinya (60708717)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
8. 今村俊彦 (30444996)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
9. 中沢洋三 (60397312)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
10. 中屋隆明 (80271633)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 松尾雅文 (10157266)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 平林耕一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yagyu Shigeki 柳生 茂希

YAGYU Shigeki 柳生 茂希

Research Projects

Research Products

Co-Researchers

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

抗原陰性再発の克服を目指した多重特異性CAR-T細胞の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of combinatorial CAR-T cell therapy improving immunosupressive tumor microenvironmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of chimeric antigen receptor T cells redirecting a growth factor receptor on human rhabdomyosarcomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Yagyu Shigeki 柳生茂希

YAGYU Shigeki 柳生茂希

[Book] 腫瘍内科 31(3) 新しいがん免疫療法研究の展開と臨床応用】臨床開発ステージに進んだ新たながん免疫療法非ウイルスベクター遺伝子導入によるCAR-T細胞療法2023

[Book] 医学のあゆみ　285巻5号【mRNAワクチンやゲノム編集で注目が集まる遺伝子治療】実用化に向けた遺伝子治療技術がんに対するCAR-T細胞療法2023

[Journal Article] 【mRNAワクチンやゲノム編集で注目が集まる遺伝子治療】がんに対するCAR-T細胞療法2023

[Journal Article] 『がん治療における分子標的:その課題と未来展望』　小児がんに対する遺伝子改変細胞療法: 基礎開発から臨床応用までの道程2023