Shiotani Bunsyo 塩谷文章

Researcher Number	10627665
Other IDs
Affiliation (Current)	2022: 国立研究開発法人国立がん研究センター, 研究所, ユニット長
Affiliation (based on the past Project Information) *help	2021 – 2022: 国立研究開発法人国立がん研究センター, 研究所, ユニット長 2015 – 2021: 国立研究開発法人国立がん研究センター, 研究所, 主任研究員 2016: 国立研究開発法人国立がん研究センター, その他部局等, 研究員 2014: 独立行政法人国立がん研究センター, その他部局等, 研究員 2014: 独立行政法人国立がん研究センター, 研究所, 主任研究員 2013: 広島大学, その他の研究科, その他 2012 – 2013: 広島大学, 医歯薬保健学研究院, 特任助教
Review Section/Research Field	Principal Investigator Risk sciences of radiation and chemicals / Basic Section 63020:Radiation influence-related / Carcinogenesis / Medium-sized Section 50:Oncology and related fields Except Principal Investigator Tumor diagnostics / Basic Section 55010:General surgery and pediatric surgery-related / Basic Section 50010:Tumor biology-related
Keywords	Principal Investigator ATR / DNA複製ストレス / DNA損傷応答 / ゲノム不安定性 / チェックポイント / Nbs1 / Rad17 / RPA / Chk1 / DNA修復 … More / ＤＮＡ損傷・修復 / ＤＮＡ複製 / 細胞周期 / 翻訳後修飾 / 細胞増殖・細胞死 / DNA damage / DNA複製 / 発がん / DNA replication stress / genome instability / KRAS / Lung cancer / 発がん機構 / 癌遺伝子 / クロマチン / がん … More Except Principal Investigator PRPF19 / 老化 / がん / 膵がん / がんの個別診断 / マイクロRNA / 核酸医薬 / がんの個性診断 / siRNA / BRCA / 複製ストレス / ATR / がん抑制遺伝子 / DNA複製ストレス / RBファミリー Less

Cellular survival strategy through ATR-dependent DNA replication stress tolerancePrincipal Investigator
- Principal Investigator
  
  塩谷文章
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 63020:Radiation influence-related
- Research Institution
  National Cancer Center Japan
DNA複製ストレス応答機構に着目したBRCA2-VUS変異陽性細胞株の特徴の検証
- Principal Investigator
  
  高橋麻衣子
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Keio University
複製ストレス応答における癌抑制因子の新機能と染色体不安定化の抑制機構の解明
- Principal Investigator
  
  内田千晴
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Hamamatsu University School of Medicine
Elucidation of the mechanism underlying DNA replication stress response regulating genomic instabilityPrincipal Investigator
- Principal Investigator
  
  塩谷文章
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 50:Oncology and related fields
- Research Institution
  National Cancer Center Japan
Elucidation of the mechanism underlying tumor initiation via DNA replication stress regulated by ATRPrincipal Investigator
- Principal Investigator
  
  Shiotani Bunsyo
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 63020:Radiation influence-related
- Research Institution
  National Cancer Center Japan
ATR functional analysis using in vitro DNA replication systemPrincipal Investigator
- Principal Investigator
  
  Shiotani Bunsyo
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Risk sciences of radiation and chemicals
- Research Institution
  National Cancer Center Japan
Application of cancer therapy of senescence-associated microRNA
- Principal Investigator
  
  Tahara Hidetoshi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Tumor diagnostics
- Research Institution
  Hiroshima University
Identification and dissection of ATR substratesPrincipal Investigator
- Principal Investigator
  
  Shiotani Bunsyo
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Risk sciences of radiation and chemicals
- Research Institution
  National Cancer Center Japan
  Hiroshima University
DSB応答におけるATRの新規活性化機構及び機能の解析Principal Investigator
- Principal Investigator
  
  塩谷文章
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Carcinogenesis
- Research Institution
  Hiroshima University

All 2020 2019 2018 2017 2016 2015 2014 2013 2012 Other

All Journal Article Presentation Book

[Book] DNA Replication, Recombination and Repair - Molecular Mechanisms and Pathology2016
- Author(s)
  Shiotani B and Zou L
- Total Pages
  24
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-16K12602
[Book] DNA Replication, Recombination, and Repair-Molecular Mechanisms and Pathology2016
- Author(s)
  Bunsyo Shiotani, Lee Zou
- Total Pages
  24
- Publisher
  Springer Japan
- Data Source
  KAKENHI-PROJECT-25701005
[Book] DNA replication, Recombination, and Repair-Molecular Mechanisms and Pathology2015
- Author(s)
  Bunstyo Shiotani and Lee Zou
- Total Pages
  24
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-25701005
[Book] 血液内科2014
- Author(s)
  塩谷文章　田原栄俊
- Total Pages
  6
- Publisher
  科学評論社
- Data Source
  KAKENHI-PROJECT-25701005
[Book] DNA Replication, Recombination and Repair - Molecular Mechanisms and Pathology,2014
- Author(s)
  Shiotani B and Zou L
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-25701005
[Journal Article] SMARCA4 deficiency-associated heterochromatin induces intrinsic DNA replication stress and susceptibility to ATR inhibition in lung adenocarcinoma2020
- Author(s)
  Kurashima K, Kashiwagi H, Shimomura I, Suzuki A, Takeshita F, Mazevet M, Harata M Yamashita T, Yamamoto Y, Kohno T, Shiotani B
- Journal Title
  
  NAR Cancer
  
  Volume: 2 Pages: 1-19
- DOI
  10.1093/narcan/zcaa005
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07772, KAKENHI-PROJECT-20K21261, KAKENHI-PROJECT-19K20456, KAKENHI-PROJECT-18KK0235, KAKENHI-PROJECT-18H03378, KAKENHI-PUBLICLY-20H05378, KAKENHI-PROJECT-18H02164
[Journal Article] Human Rad52 Promotes XPG-Mediated R-loop Processing to Initiate Transcription-Associated Homologous Recombination Repair.2018
- Author(s)
  Yasuhara Takaaki、Kato Reona、Hagiwara Yoshihiko、Shiotani Bunsyo、Yamauchi Motohiro、Nakada Shinichiro、Shibata Atsushi、Miyagawa Kiyoshi
- Journal Title
  
  Cell
  
  Volume: 175 Pages: 558-570
- DOI
  10.1016/j.cell.2018.08.056
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K18191, KAKENHI-PROJECT-18KK0235, KAKENHI-PROJECT-18H03378, KAKENHI-PROJECT-16K12602, KAKENHI-PROJECT-26241014, KAKENHI-PROJECT-17H04713
[Journal Article] requent amplification of receptor tyrosine kinase genes in welldifferentiated/ dedifferentiated liposarcoma2017
- Author(s)
  Asano N, Yoshida A, Mitani S, Kobayashi E, Shiotani B, Komiyama M, Fujimoto H, Chuman H, Morioka H, Matsumoto M, Nakamura M, Kubo T, Kato M, Kohno T, Kawai A, Kondo T, Ichikawa H.
- Journal Title
  
  Oncotarget.
  
  Volume: 8 Pages: 12941-12952
- DOI
  10.18632/oncotarget.14652
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26293342, KAKENHI-PROJECT-25701005, KAKENHI-PROJECT-16K12602
[Journal Article] UV Damage-Induced Phosphorylation of HBO1 Triggers CRL4DDB2-Mediated Degradation to Regulate Cell proliferation.2016
- Author(s)
  Matsunuma R, Niida H, Ohhata T, Kitagawa K, Sakai S, Uchida C, Shiotani B, Matsumoto M, Nakayama KI, Ogura H, Shiiya N, Kitagawa M.
- Journal Title
  
  Mol. Cell. Biol.
  
  Volume: 36 Pages: 394-406
- DOI
  10.1128/mcb.00809-15
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01407, KAKENHI-PROJECT-24390072, KAKENHI-PROJECT-25290044, KAKENHI-PROJECT-25290078, KAKENHI-PROJECT-25701005, KAKENHI-PUBLICLY-26116721
[Journal Article] CBP-93872 inhibits NBS1-mediated ATR activation, abrogating maintenance of the DNA double-strand break–specific G2 checkpoint.2014
- Author(s)
  Hirokawa T, Shiotani B, Shimada M, Murata K, Johmura Y, Haruta M, Tahara H, Takeyama H, Nakanishi M.
- Journal Title
  
  Cancer Research
  
  Volume: 74 Pages: 3880-3889
- DOI
  10.1158/0008-5472.can-13-3604
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-22118003, KAKENHI-PUBLICLY-25112711, KAKENHI-PROJECT-25293290, KAKENHI-PROJECT-25701005, KAKENHI-PROJECT-26250027, KAKENHI-PROJECT-26290047, KAKENHI-PROJECT-26310106, KAKENHI-PROJECT-26640091, KAKENHI-PROJECT-26860195, KAKENHI-PROJECT-221S0001
[Journal Article] DSE-FRET: A new anticancer drug screening assay for DNA binding proteins.2014
- Author(s)
  Miyagi T, Shiotani B, Miyoshi R, Yamamoto T, Oka T, Umezawa K, Ochiya T, Takano M, Tahara H
- Journal Title
  
  Cancer Science
  
  Volume: (in press) Pages: 870-874
- DOI
  10.1111/cas.12420
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23300363, KAKENHI-PROJECT-24650645, KAKENHI-PUBLICLY-25112711, KAKENHI-PROJECT-25701005, KAKENHI-PROJECT-26290047, KAKENHI-PROJECT-26310106, KAKENHI-PROJECT-26640091, KAKENHI-PROJECT-221S0001
[Journal Article] Curcumin suppresses multiple DNA damage response pathways and has potency as a sensitizer to PARP inhibitor2013
- Author(s)
  Ogiwara H, Ui A, Shiotani B, Zou L, Yasui A, Kohno T
- Journal Title
  
  Carciogenesis
  
  Volume: 34 Pages: 2486-2497
- DOI
  10.1093/carcin/bgt240
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22131006, KAKENHI-PROJECT-23701110, KAKENHI-PROJECT-24310037, KAKENHI-PROJECT-24710057, KAKENHI-PROJECT-25701005
[Journal Article] Two distinct modes of ATR activation orchestrated by Rad17 and Nbs1.2013
- Author(s)
  Shiotani B, Nguyen HD, Hakansson P, Marechal A, Tse A, Tahara H, Zou L
- Journal Title
  
  Cell reports
  
  Volume: 3(5) Pages: 1651-1662
- DOI
  10.1016/j.celrep.2013.04.018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23300363, KAKENHI-PROJECT-24650645, KAKENHI-PROJECT-24800044, KAKENHI-PUBLICLY-25112711, KAKENHI-PROJECT-25701005, KAKENHI-PROJECT-221S0001
[Presentation] 肺腺がんにおけるSMARCA4欠損関連性ヘテロクロマチンによる内在性DNA複製ストレスとATR阻害感受性の誘導2020
- Author(s)
  塩谷文章
- Organizer
  日本放射線影響学会第63回大会
- Invited
- Data Source
  KAKENHI-PROJECT-18H03378
[Presentation] SMARCA4 defects-associated heterochromatin induces intrinsic DNA replication stress and vulnerability to ATR inhibition in lung adenocarcinoma2020
- Author(s)
  Bunsyo Shiotani
- Organizer
  第24回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-18KK0235
[Presentation] DNA replication stress Cause and consequence of cancer2020
- Author(s)
  Bunsyo Shiotani
- Organizer
  第43回日本分子生物学会オンライン年会
- Invited
- Data Source
  KAKENHI-PROJECT-18KK0235
[Presentation] A new therapeutic strategy for lung cancer with tumor suppressor gene mutations2020
- Author(s)
  Bunsyo Shiotani
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18H03378
[Presentation] SMARCA4 defects-associated heterochromatin induces intrinsic DNA replication stress and vulnerability to ATR inhibition in lung adenocarcinoma2020
- Author(s)
  Bunsyo Shiotani
- Organizer
  第24回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-18H03378
[Presentation] DNA replication stress Cause and consequence of cancer2020
- Author(s)
  Bunsyo Shiotani
- Organizer
  第43回日本分子生物学会オンライン年会
- Invited
- Data Source
  KAKENHI-PROJECT-18H03378
[Presentation] A new therapeutic strategy for lung cancer with tumor suppressor gene mutations2020
- Author(s)
  Bunsyo Shiotani
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18KK0235
[Presentation] 発がん過程におけるDNA複製ストレスに対するATR応答機構2019
- Author(s)
  塩谷文章
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18H03378
[Presentation] SMARCA4 deficiency Confers Sensitivity to ATR Inhibitor in Lung Adenocarcinoma Cells2019
- Author(s)
  塩谷文章倉島公憲河野隆志
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18KK0235
[Presentation] SMARCA4欠損は内在性DNA複製ストレスの増加とreversed forkの不安定化を誘導しATR阻害剤感受性を高める2019
- Author(s)
  倉島公憲　柏木秀人　山下孝之　河野隆志　塩谷文章
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18KK0235
[Presentation] SWI/SNFクロマチン再構成異常を標的としたATR阻害剤によるがん治療基盤確立2019
- Author(s)
  倉島公憲　塩谷文章
- Organizer
  第8回DNA損傷応答ワークショップ
- Data Source
  KAKENHI-PROJECT-18H03378
[Presentation] SMARCA4欠損はDNA複製ストレスの上昇と複製フォークの不安定化によりATR阻害剤感受性を高める2019
- Author(s)
  倉島公憲河野隆志塩谷文章
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18H03378
[Presentation] SWI/SNFクロマチン再構成異常を標的としたATR阻害剤によるがん治療基盤確立2019
- Author(s)
  倉島公憲　塩谷文章
- Organizer
  第8回DNA損傷応答ワークショップ
- Data Source
  KAKENHI-PROJECT-18KK0235
[Presentation] 発がん過程におけるDNA複製ストレスに対するATR応答機構2019
- Author(s)
  塩谷文章
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18KK0235
[Presentation] SMARCA4 deficiency Confers Sensitivity to ATR Inhibitor in Lung Adenocarcinoma Cells2019
- Author(s)
  塩谷文章倉島公憲河野隆志
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18H03378
[Presentation] 肺腺がん細胞における内在性DNA複製ストレスを標的とするATR阻害療法2019
- Author(s)
  塩谷文章
- Organizer
  第23回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-18H03378
[Presentation] p130RB2はDNA複製ストレスにおけるATR活性化に正に関わる2019
- Author(s)
  内田千晴　丹伊田浩行　塩谷文章　北川雅敏
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18H03378
[Presentation] p130RB2はDNA複製ストレスにおけるATR活性化に正に関わる2019
- Author(s)
  内田千晴　丹伊田浩行　塩谷文章　北川雅敏
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18KK0235
[Presentation] 肺腺がん細胞における内在性DNA複製ストレスを標的とするATR阻害療法2019
- Author(s)
  塩谷文章
- Organizer
  第23回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-18KK0235
[Presentation] SMARCA4欠損はDNA複製ストレスの上昇と複製フォークの不安定化によりATR阻害剤感受性を高める2019
- Author(s)
  倉島公憲河野隆志塩谷文章
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18KK0235
[Presentation] SMARCA4欠損は内在性DNA複製ストレスの増加とreversed forkの不安定化を誘導しATR阻害剤感受性を高める2019
- Author(s)
  倉島公憲　柏木秀人　山下孝之　河野隆志　塩谷文章
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18H03378
[Presentation] がん遺伝子誘導性DNA複製ストレスに対するATR応答機構2018
- Author(s)
  Bunsyo Shiotani
- Organizer
  第41回　日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18KK0235
[Presentation] 内在性DNA複製ストレスを標的とした肺線がん細胞におけるATR阻害療法2018
- Author(s)
  塩谷文章
- Organizer
  日本放射線腫瘍学会
- Invited
- Data Source
  KAKENHI-PROJECT-18KK0235
[Presentation] Intrinsic DNA Replication Stress Provides an Indication of Sensitivity to ATR inhibitor in Lung Adenocarcinoma Cell2018
- Author(s)
  倉島公憲、柏木秀人、河野隆志、塩谷文章
- Organizer
  第41回　日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18H03378
[Presentation] Intrinsic DNA Replication Stress Provides an Indication of Sensitivity to ATR inhibitor in Lung Adenocarcinoma Cel2018
- Author(s)
  倉島公憲、柏木秀人、河野隆志、塩谷文章
- Organizer
  第41回　日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18KK0235
[Presentation] 内在性DNA複製ストレスを標的とした肺線がん細胞におけるATR阻害療法2018
- Author(s)
  塩谷文章
- Organizer
  日本放射線腫瘍学会
- Invited
- Data Source
  KAKENHI-PROJECT-18H03378
[Presentation] DNA replication stress response regulated by ATR in cancer cells2018
- Author(s)
  塩谷文章
- Organizer
  DNA損傷ワークショップ
- Data Source
  KAKENHI-PROJECT-18H03378
[Presentation] がん遺伝子誘導性DNA複製ストレスに対するATR応答機構2018
- Author(s)
  Bunsyo Shiotani
- Organizer
  第41回　日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18H03378
[Presentation] DNA replication stress response regulated by ATR in cancer cells2018
- Author(s)
  塩谷文章
- Organizer
  DNA損傷ワークショップ
- Data Source
  KAKENHI-PROJECT-18KK0235
[Presentation] Intrinsic DNA Replication Stress Confers Sensitivity to ATR Inhibitor in Lung Adenocarcinoma Cell2018
- Author(s)
  Kiminori Kurasima, Takashi Kohno, and Bunsyo Shiotani
- Organizer
  第77回　日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18KK0235
[Presentation] 内在性DNA複製ストレスを標的とした肺線がん細胞におけるATR阻害療法2018
- Author(s)
  塩谷文章
- Organizer
  日本放射線腫瘍学会
- Invited
- Data Source
  KAKENHI-PROJECT-16K12602
[Presentation] DNA replication stress response regulated by ATR in cancer cells2018
- Author(s)
  塩谷文章
- Organizer
  DNA損傷ワークショップ
- Data Source
  KAKENHI-PROJECT-16K12602
[Presentation] Intrinsic DNA Replication Stress Confers Sensitivity to ATR Inhibitor in Lung Adenocarcinoma Cell2018
- Author(s)
  Kiminori Kurasima, Takashi Kohno, and Bunsyo Shiotani
- Organizer
  第77回　日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16K12602
[Presentation] Intrinsic DNA Replication Stress Confers Sensitivity to ATR Inhibitor in Lung Adenocarcinoma Cell.2018
- Author(s)
  Bunsyo Shiotani
- Organizer
  Gordon Research Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18KK0235
[Presentation] がん遺伝子誘導性DNA複製ストレスに対するATR応答機構2018
- Author(s)
  Bunsyo Shiotani
- Organizer
  第41回　日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-16K12602
[Presentation] Intrinsic DNA Replication Stress Confers Sensitivity to ATR Inhibitor in Lung Adenocarcinoma Cell2018
- Author(s)
  Kiminori Kurasima, Takashi Kohno, and Bunsyo Shiotani
- Organizer
  第77回　日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18H03378
[Presentation] Intrinsic DNA Replication Stress Confers Sensitivity to ATR Inhibitor in Lung Adenocarcinoma Cell.2018
- Author(s)
  Bunsyo Shiotani
- Organizer
  Gordon Research Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H03378
[Presentation] Intrinsic DNA Replication Stress Provides an Indication of Sensitivity to ATR inhibitor in Lung Adenocarcinoma Cell2018
- Author(s)
  倉島公憲、柏木秀人、河野隆志、塩谷文章
- Organizer
  第41回　日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-16K12602
[Presentation] Elucidation of the mechanism underlying development and maintenance of tumor by ATR-dependent DNA replication stress response2017
- Author(s)
  塩谷文章
- Organizer
  Conbio2017
- Data Source
  KAKENHI-PROJECT-16K12602
[Presentation] ATR overexpression promotes K-Ras induced tumorigenesis through replication fork protection2017
- Author(s)
  Marianne Mazevet, Naoya Hayashida, Bunsyo Shiotani
- Organizer
  Conbio2017
- Data Source
  KAKENHI-PROJECT-16K12602
[Presentation] Oncogenic DNA replication stress response regulated by ATR2017
- Author(s)
  塩谷文章
- Organizer
  第６回DNA損傷ワークショップ
- Data Source
  KAKENHI-PROJECT-16K12602
[Presentation] Elucidation of the mechanism underlying lung adenocarcinoma cell death induced by ATR inhibitor2017
- Author(s)
  林田　直也、マズヴェ　マリアンヌ、　塩谷文章
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16K12602
[Presentation] Sensing and signaling of DNA damage by master checkpoint kinase ATM and ATR2016
- Author(s)
  Bunsyo Shiotani and Hitoshi Zembustu
- Organizer
  Tenth AACR-JCA Joint Conference
- Place of Presentation
  Hawai
- Year and Date
  2016-02-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25701005
[Presentation] がん治療を目的としたPRPF19siRNAの核酸医薬への応用2016
- Author(s)
  矢野公義,塩谷文章,福永早央里,高木翔太,木根原匡希,嶋本顕,田原栄俊
- Organizer
  第8回日本RNAi研究会
- Place of Presentation
  グランドプリンスホテル広島
- Data Source
  KAKENHI-PROJECT-26290047
[Presentation] Dark side of ATR2016
- Author(s)
  塩谷文章
- Organizer
  DNA 損傷応答ワークショップ浜名湖ミーティング
- Place of Presentation
  浜名湖弁天リゾートジ・オーシャン（静岡県　浜松市）
- Year and Date
  2016-04-04
- Data Source
  KAKENHI-PROJECT-25701005
[Presentation] Development of a direct ATR substrates identification system utilizing ATP analog2016
- Author(s)
  Bunsyo Shiotani
- Organizer
  Gordon Research Conference
- Place of Presentation
  Hong Kong (China)
- Year and Date
  2016-07-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25701005
[Presentation] Identification of ATR substrates utilizing analog ATP sensitive-ATR2016
- Author(s)
  Bunsyo Shiotani
- Organizer
  第75回　日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜　（神奈川県・横浜市）
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-16K12602
[Presentation] Establishment of direct substrates identifying system by analog sensitive-ATR kinase2016
- Author(s)
  Bunsyo Shiotani
- Organizer
  第39回　日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜　（神奈川県・横浜市）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-16K12602
[Presentation] Identification of ATR substrates utilizing analog ATP sensitive-ATR2016
- Author(s)
  Bunsyo Shiotani
- Organizer
  第75回　日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜　（神奈川県　横浜市）
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-25701005
[Presentation] Development of a direct ATR substrates identification system utilizing ATP analog2016
- Author(s)
  Bunsyo Shiotani
- Organizer
  Gordon Research Conference
- Place of Presentation
  Hong Kong (China)
- Year and Date
  2016-07-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K12602
[Presentation] Dark side of ATR2016
- Author(s)
  塩谷　文章
- Organizer
  DNA 損傷ワークショップ　浜名湖ミーティング
- Place of Presentation
  浜名湖弁天リゾートジ・オーシャン　(静岡県・浜松市）
- Year and Date
  2016-04-04
- Data Source
  KAKENHI-PROJECT-16K12602
[Presentation] DNA Damage Response in Human Induced Pluripotent Stem Cells2015
- Author(s)
  Akira Shimamoto,Harunobu Kagawa,Hidehiko Kawai,Tetsushi Sakuma,Takashi Yamamoto,Bunsyo Shiotani,Hidetoshi Tahara
- Organizer
  第15回国際放射線研究会議（ICRR2015）
- Place of Presentation
  京都市
- Year and Date
  2015-05-25
- Data Source
  KAKENHI-PROJECT-26290047
[Presentation] Depletion of PRPF19 regulates cell fate between cellular senescence and cell death2015
- Author(s)
  矢野公義,福永早央里,高木翔太,塩谷文章,木根原匡希,村岡賢,嶋本顕,田原栄俊
- Organizer
  BMB2015
- Place of Presentation
  神戸市
- Year and Date
  2015-12-03
- Data Source
  KAKENHI-PROJECT-26290047
[Presentation] Nbs1-mediated ATR activation maintaining G2 checkpoint at resected DNA double stranded breaks2015
- Author(s)
  Bunsyo Shiotani Takahisa Hirokawa, Makoto Nakanishi, and Lee Zou
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-25701005
[Presentation] Identification and dissection of ATR substrates2015
- Author(s)
  塩谷文章
- Organizer
  国立遺伝学研究所・研究集会「染色体DNAの安定維持の分子メカニズム」
- Place of Presentation
  三島
- Year and Date
  2015-10-01
- Data Source
  KAKENHI-PROJECT-25701005
[Presentation] ATPアナログを利用したATR基質同定法の開発2015
- Author(s)
  Bunsyo Shiotani
- Organizer
  BMB2015
- Place of Presentation
  神戸
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25701005
[Presentation] PRPF19をノックダウンしたことによる細胞老化誘導と細胞死誘導の制御機構の解明2015
- Author(s)
  矢野公義,福永早央里,塩谷文章,木根原匡希,村岡賢,嶋本顕,田原栄俊
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋市
- Year and Date
  2015-10-10
- Data Source
  KAKENHI-PROJECT-26290047
[Presentation] ATMとATRが制御するDNA二本鎖切断部位におけるゲノム安定性維持機構2015
- Author(s)
  塩谷文章、前佛均、Lee Zou
- Organizer
  日本人類遺伝学会第60回大会
- Place of Presentation
  新宿
- Year and Date
  2015-10-14
- Data Source
  KAKENHI-PROJECT-25701005
[Presentation] 細胞老化を誘導する microRNA の網羅的スクリーニングとその機能解析2015
- Author(s)
  山本佑樹, 福永早央里, 高木翔太, 木根原匡希, 村岡賢, 塩谷文章, 嶋本顕, 田原栄俊
- Organizer
  日本組織培養学会　第88回大会
- Place of Presentation
  広島市
- Year and Date
  2015-05-26
- Data Source
  KAKENHI-PROJECT-26290047
[Presentation] Revisiting ATR functions in safeguarding genome stability2015
- Author(s)
  塩谷文章
- Organizer
  第4回DNA損傷ワークショップ
- Place of Presentation
  浜名湖
- Year and Date
  2015-04-02
- Data Source
  KAKENHI-PROJECT-25701005
[Presentation] PRPF19 siRNA を用いた抗腫瘍効果の機構解明2015
- Author(s)
  矢野公義,福永早央里,高木翔太,塩谷文章,木根原匡希,村岡賢, 嶋本顕,田原栄俊
- Organizer
  第7回日本RNAi研究会
- Place of Presentation
  広島市
- Year and Date
  2015-08-27
- Data Source
  KAKENHI-PROJECT-26290047
[Presentation] 老化を調節する microRNA による膵臓がん抑制機構の解析2014
- Author(s)
  福永早央里,塩谷文,嶋本顕,田原栄俊
- Organizer
  第６回日本RNAi研究会
- Place of Presentation
  広島市
- Year and Date
  2014-08-28
- Data Source
  KAKENHI-PROJECT-26290047
[Presentation] 細胞老化における細胞外小胞エクソソーム分泌の生物学的意義の探索2014
- Author(s)
  岡田恵,宗岡美紗,岡本沙矢香,二瀬由宇,塩谷文章,嶋本顕,田原栄俊３
- Organizer
  第６回日本RNAi研究会
- Place of Presentation
  広島市
- Year and Date
  2014-08-29
- Data Source
  KAKENHI-PROJECT-26290047
[Presentation] microRNA による細胞老化誘導機構の解明2014
- Author(s)
  山本佑樹, 塩谷文章, 嶋本顕, 田原栄俊
- Organizer
  第37回日本分子生物学会
- Place of Presentation
  横浜市
- Year and Date
  2014-11-26
- Data Source
  KAKENHI-PROJECT-26290047
[Presentation] 細胞老化を誘導する microRNA の網羅的スクリーニング2014
- Author(s)
  山本佑樹, 塩谷文章, 嶋本顕, 田原栄俊
- Organizer
  第６回日本RNAi研究会
- Place of Presentation
  広島市
- Year and Date
  2014-08-28
- Data Source
  KAKENHI-PROJECT-26290047
[Presentation] 老化を調節する microRNA の膵臓がん細胞における機能解析2014
- Author(s)
  福永早央里, 塩谷文章, 嶋本顕, 田原栄俊
- Organizer
  第37回日本分子生物学会
- Place of Presentation
  横浜市
- Year and Date
  2014-11-26
- Data Source
  KAKENHI-PROJECT-26290047
[Presentation] PRPF19の発現抑制による細胞老化誘導とがん分子標的としての可能性2013
- Author(s)
  塩谷文章
- Organizer
  第17回日本がん分子標的治療学会学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-24800044
[Presentation] Regulation of ATR checkpoint pathway at DSB2013
- Author(s)
  塩谷文章
- Organizer
  第２回DNA損傷応答ワークショップ
- Place of Presentation
  浜名湖
- Data Source
  KAKENHI-PROJECT-25701005
[Presentation] 細胞老化におけるPRPF19の発現抑制に関与するmiR-27bの解析2013
- Author(s)
  志戸岡友希, 鶴崎慎也, 塩谷文章, 嶋本顕, 田原栄俊
- Organizer
  日本分子生物学年会36回
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-25701005
[Presentation] ATR activation regulated by Nbs1 at DSB2013
- Author(s)
  塩谷文章
- Organizer
  第65回日本細胞生物学会大会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-24800044
[Presentation] ATR activation regulated by Nbs1 at DSB2013
- Author(s)
  塩谷文章、田原栄俊、Zou Lee,
- Organizer
  第65回日本細胞生物学会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-25701005
[Presentation] 人工多能性幹細胞における X 線に対する高感受性細胞死の p53 依存的な誘導機構の解明2013
- Author(s)
  香川晴信, 河合秀彦, 佐久間哲史, 山本卓, 塩谷文章, 嶋本顕, 田原栄俊
- Organizer
  日本分子生物学年会36回
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-25701005
[Presentation] PRPF19 をターゲットとした siRNA の抗がん剤としての応用の可能性2013
- Author(s)
  鶴崎慎也, 塩谷文章, 志戸岡友希, 嶋本顕,田原栄俊
- Organizer
  日本分子生物学年会36回
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-25701005
[Presentation] Regulation of ATR checkpoint pathway at DSB2013
- Author(s)
  塩谷文章
- Organizer
  第2回DNA損傷応答ワークショップ浜名湖ミーティング
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-24800044
[Presentation] 56. Telomere DSE-FRET assay を用いた、テロメア結合タンパク質TRF2の結合阻害剤の探索と機能解析2013
- Author(s)
  三好龍也, 新家一男, 清宮啓之, 塩谷文章, 嶋本顕, 田原栄俊
- Organizer
  日本分子生物学年会36回
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-25701005
[Presentation] 細胞老化におけるPRPF19 の発現抑制に関与するmiRNAの解析2013
- Author(s)
  志戸岡友希、塩谷文章、鶴崎慎也、田原栄俊
- Organizer
  日本RNAi研究会第5回
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-25701005
[Presentation] ATM/ATR依存的リン酸化はHBO1を複製起点から遊離させる2013
- Author(s)
  丹伊田浩行, 塩谷文章, 松本雅記, 西谷秀男, 北川雅敏
- Organizer
  日本分子生物学年会36回
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-25701005
[Presentation] PRPF19の発現抑制による細胞老化誘導とがん分子標的としての可能性2013
- Author(s)
  塩谷文章、田原栄俊
- Organizer
  第17回がん分子標的治療学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-25701005
[Presentation] PRPF19の発現抑制はDNA損傷を誘発し細胞老化を誘導する2013
- Author(s)
  塩谷文章、志戸岡友希、田原栄俊
- Organizer
  日本癌学会第72回総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-25701005
[Presentation] Mechanistic studies on cellular senescence induced by depletion of PRPF192012
- Author(s)
  塩谷文章
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-24800044
[Presentation] 第４回日本RNAI研究会2012
- Author(s)
  塩谷文章
- Organizer
  細胞老化におけるPRPF19の発現抑制に及ぼす老化関連miRNA解析
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-24800044
[Presentation] Two Distinct Modes of ATR Activation Orchestrated by Rad17 and Nbs12012
- Author(s)
  塩谷文章
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24800044
[Presentation] The mechanism underlying ATR activation during DNA damage response2012
- Author(s)
  塩谷文章
- Organizer
  平成24年度がん若手研究者ワークショップ
- Place of Presentation
  長野
- Data Source
  KAKENHI-PROJECT-24800044
[Presentation] Sensing and signaling of DNA damage by master checkpoint kinase ATM and ATR2012
- Author(s)
  塩谷文章
- Organizer
  第４回日本RNAI研究会 Perkin Elmer ランチョンセミナー
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-24800044
[Presentation] 細胞老化を誘導する microRNA の網羅的スクリーニング
- Author(s)
  山本佑樹, 塩谷文章, 嶋本顕, 田原栄俊
- Organizer
  平成 26 年度がん若手研究者ワークショップ
- Place of Presentation
  長野県茅野市
- Year and Date
  2014-09-03 – 2014-09-06
- Data Source
  KAKENHI-PROJECT-26290047
[Presentation] Silencing of PRPF19 triggers cellular senescence in normal human fibroblasts
- Author(s)
  塩谷文章
- Organizer
  第１回　Genome Damage Network Workshop
- Place of Presentation
  仙台
- Year and Date
  2014-06-05 – 2014-06-06
- Data Source
  KAKENHI-PROJECT-25701005
[Presentation] miR-27bの発現上昇に伴う標的遺伝子PRPF19の発現低下はヒト繊維芽細胞の細胞老化に関与する
- Author(s)
  志戸岡友希　塩谷文章　矢野公義　嶋本彰　田原栄俊
- Organizer
  第６回RNAi研究会
- Place of Presentation
  広島
- Year and Date
  2014-08-28 – 2014-08-30
- Data Source
  KAKENHI-PROJECT-25701005
[Presentation] Depletion of PRPF19 induces cellular senescence through p53-mediated mechanism
- Author(s)
  unsyo Shiotani, Tomoki Shidooka, and Hidetoshi Tahara
- Organizer
  第７３回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-25701005
[Presentation] NFkB DSE-FRET assay を用いた、転写因子NFkB結合阻害剤の探索
- Author(s)
  山本拓弥　宮城徹　塩谷文章　嶋本彰　田原栄俊
- Organizer
  第１８回　がん分子標的治療学会
- Place of Presentation
  仙台
- Year and Date
  2014-06-25 – 2014-06-27
- Data Source
  KAKENHI-PROJECT-25701005
[Presentation] Activation and regulation of ATR at double-stranded DNA breaks
- Author(s)
  Bunsyo Shiotani
- Organizer
  日本放射線影響学会第５７回大会
- Place of Presentation
  鹿児島
- Year and Date
  2014-10-01 – 2014-10-03
- Data Source
  KAKENHI-PROJECT-25701005
[Presentation] PRPF19発現抑制による正常細胞老化誘導機構
- Author(s)
  塩谷文章
- Organizer
  第３回DNA損傷応答ワークショップ
- Place of Presentation
  浜名湖
- Year and Date
  2014-04-03 – 2014-04-04
- Data Source
  KAKENHI-PROJECT-25701005
[Presentation] Two distinct modes of ATR activation orchestrated by Rad17 and Nbs1 at resected DNA double stranded breaks
- Author(s)
  Bunsyo Shiotani, Takahisa Hirokawa, Hai Dang Nguyen, Pelle Hakansson, Alexandre Marechal, Alice Tse, Hidetoshi Tahara, Makoto Nakanishi, and Lee Zou
- Organizer
  Gordon Research Conference Genome Instability
- Place of Presentation
  Hong Kong
- Year and Date
  2014-07-06 – 2014-07-11
- Data Source
  KAKENHI-PROJECT-25701005
[Presentation] Biphasic activation of ATR induced by DSBs
- Author(s)
  Bunsyo Shiotani
- Organizer
  国立遺伝研究所　研究集会「染色体DNAの安定維持の分子メカニズム」
- Place of Presentation
  三島
- Year and Date
  2014-11-06 – 2014-11-07
- Data Source
  KAKENHI-PROJECT-25701005
[Presentation] microRNA による細胞老化誘導機構の解明
- Author(s)
  山本佑樹, 塩谷文章, 嶋本顕, 田原栄俊
- Organizer
  第３７回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-25701005
[Presentation] PRPF19の発現抑制による細胞老化及び老化誘導型抗がん核酸医薬の可能性
- Author(s)
  塩谷文章　田原栄俊
- Organizer
  第１８回　がん分子標的治療学会
- Place of Presentation
  仙台
- Year and Date
  2014-06-25 – 2014-06-27
- Data Source
  KAKENHI-PROJECT-25701005
[Presentation] NFkB DSE-FRET assay を用いた、転写因子NFkB結合阻害剤の探索
- Author(s)
  山本拓弥　宮城徹　塩谷文章　梅澤一夫　田原栄俊
- Organizer
  第３７回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-25701005
[Presentation] 人工多能性幹細胞（iPS細胞）のX線高感受性の分子機構
- Author(s)
  嶋本彰　香川晴信　河合秀彦　佐久間哲史　山本卓　塩谷文章　田原栄俊
- Organizer
  日本放射線影響学会第５７回大会
- Place of Presentation
  鹿児島
- Year and Date
  2014-10-01 – 2014-10-03
- Data Source
  KAKENHI-PROJECT-25701005

1. Tahara Hidetoshi (00271065)

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2. 中田慎一郎 (70548528)

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3. 安原崇哲 (90757056)

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4. 足立淳 (20437255)

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5. 白石友一 (70516880)

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6. 高橋麻衣子 (50348661)

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7. 永山愛子 (00573396)

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8. 関朋子 (70528900)

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9. 林田哲 (80327543)

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11. 丹伊田浩行 (20336671)

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12. 北川雅敏 (50294971)

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13. TAKANO Atsushi

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14. 近藤格

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15. 市川仁

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16. 川井章

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17. 吉田朗彦

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18. 中西真

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19. 竹山廣光

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20. 城村由和

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22. 河野隆志

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Shiotani Bunsyo 塩谷 文章

Research Projects

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Co-Researchers

Cellular survival strategy through ATR-dependent DNA replication stress tolerancePrincipal Investigator

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DNA複製ストレス応答機構に着目したBRCA2-VUS変異陽性細胞株の特徴の検証

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複製ストレス応答における癌抑制因子の新機能と染色体不安定化の抑制機構の解明

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Elucidation of the mechanism underlying DNA replication stress response regulating genomic instabilityPrincipal Investigator

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Elucidation of the mechanism underlying tumor initiation via DNA replication stress regulated by ATRPrincipal Investigator

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ATR functional analysis using in vitro DNA replication systemPrincipal Investigator

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Application of cancer therapy of senescence-associated microRNA

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Identification and dissection of ATR substratesPrincipal Investigator

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DSB応答におけるATRの新規活性化機構及び機能の解析Principal Investigator

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[Book] DNA Replication, Recombination and Repair - Molecular Mechanisms and Pathology2016

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[Book] DNA Replication, Recombination, and Repair-Molecular Mechanisms and Pathology2016

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[Book] DNA replication, Recombination, and Repair-Molecular Mechanisms and Pathology2015

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[Book] 血液内科2014

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Data Source

[Book] DNA Replication, Recombination and Repair - Molecular Mechanisms and Pathology,2014

Author(s)

Shiotani Bunsyo 塩谷文章