HORIO Masatsugu 堀正二

… Alternative Names

HORI Masatsugu 堀正二

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Researcher Number	20124779
Other IDs
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Affiliation (based on the past Project Information) *help	2004 – 2007: 大阪大学, 医学系研究科, 教授 2005: 大阪大学, 医学系研究科・酔う需 1999 – 2002: Osaka University Graduate School of Medicine, Professor, 医学系研究科, 教授 1996 – 1998: Faculty of Medicine, Osaka University, Professor, 医学部, 教授 1996: 大阪大学, 医学部附属病院, 講師 … More 1994 – 1995: 大阪大学, 医学部(病), 講師 1994 – 1995: Osaka Univ., Medical School., Associate Prof., 医学部, 講師 1986 – 1994: 大阪大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Circulatory organs internal medicine / Circulatory organs internal medicine Except Principal Investigator Circulatory organs internal medicine / Circulatory organs internal medicine
Keywords	Principal Investigator アデノシン / Mn-SOD / adenosine / 心不全 / プレコンディショニング / heart failure / protein kinase C / 5'-nucleotidase / ischemic preconditioning / α_1アドレナリン受容体 … More / Na^+ / 心筋梗塞 / 心肥大 / beta-adrenergic receptor down-regulation / catecholamine / sympathetic nerve activity / congestive heart failure / 微小循環障害 / β受容体 / 遷延性心筋虚血 / down-regulation / β交感神経受容体 / カテコラミン / 交感神経活性 / 慢性心不全 / nitric oxide / preconditioning / myocardial infarction / Nitric Oxide / Serum Bank / DNA bank / Large-scale, prospective, multicenter clinical investigation / Acute myocardial infarction / DNA-バンク / 多施設共同大規模臨床検査 / 血清バンク / DNAバンク / 多施設共同大規模臨床試験 / 急性心筋梗塞 / S6 kinase / ect0-5'-nucleotidase / MAPK / oxygen radical / Preconditioning / カルシウム拮抗薬 / カリウムチャネル / 心筋保護 / S6 kinsase / ecto-5'-nucleotidase / MAPキナーゼ / 活性酸素ラジカル / スーパーオキシド / プレコンディショニング現象 / Inflammation / Oxidative Stress / Acute Coronary Syndrome / 細胞障害 / TNF-α / 温熱負荷 / 血管平滑筋細胞 / 炎症 / 酸化ストレス / 急性冠症候群 / cellular biology / myocardial cell / nuclear localization signal / intracellular signal transduction / 細胞機能 / 心筋 / 細胞生物学 / 心筋細胞 / 核局在化シグナル / 細胞内情報伝達 / protein kinase C isozyme / phosphorylation / infarct size-limiting effect / alpha_1 adrenoceptor / protein kianse C / 5′-nucleotidase / PKCアイソザイム / 心筋壊死縮小 / Ca^<++>-overload / Ischemia / Adenosine / Autoregulation / Stunning / 冠予備能 / Ca過負荷 / 冠血管 / 虚血・再潅流障害 / Ca^<++> overload / sturning / corcnary autoregulation / ischewia・reperfusion / カルシウムオーバーロード / 虚血 / 冠血流自己調節能 / スタニング / myocardial stunning / alpha1-adrenoceptorstimulation / reperfusion / ischemia / ヨヒンビン / プロプラノロ-ル / α1ーアドレナリン受容体 / 再潅流障害 / 心筋スタニング / 再灌流障害 / プラゾシン / 心筋虚血 / Ca^<2+> exchange / H^+ exchange / Intracellular pH / Cardiac hypertrophy / Cardiomyopathic Syrian hamster / beta-adrenergic receptor / alpha-adrenergic receptor / Heart failure / プロテインキナ-ゼC / Ca^<2+>交換系 / H^+交換系 / 交感神経β受容体 / 交感神経α受容体 / Ca^<2+> 交換系 / H^+ 交換系 / 細胞内pH / 心筋症自然発症ハムスタ- / 交換神経β受容体 / 交換神経α受容体 / 疫学調査 / 遺伝子多型 / 遺伝子改変マウス / プロセシング / 増殖因子 … More Except Principal Investigator 心不全 / アデノシン / PKC / ecto-5'-nucleotidase / 動脈硬化 / 心筋梗塞 / Adenosine / ATP / 急性心筋梗塞 / 血管内皮細胞 / ずり応力 / 5F-BAPTA / J-WIND / PKA / Preconditioning / P38 MAP Kinase / P70S6 Kinase / KATP Channels / KATPチャネル開口剤 / 多施設臨床試験 / プレコンディショニング / P38MAPK / P70S6キナーゼ / KATPチャネル / Ecto-5'-Nucleotidase / 慢性心不全 / Ultrasound / 超音波 / 遺伝子発現 / 5'-nucleotidase / Reperfusion / Doppler / Shear Stress / atherosclerosis / 心筋細胞 / 心肥大 / Mn-SOD / Calcium Overload / Fluorine Nuclear Magnetic Resonance / Intracellular free Ca^<2+> / Isolated, perfused heart / Ischemia / カルシウム・オーバーロード / 摘出灌流心標本 / 5FーBAPTA / カルシウム・オ-バ-ロ-ド / フッ素核磁気共鳴法 / 細胞内カルシウム濃度 / 摘出灌流心 / 再灌流障害 / 虚血 / Microfilament bundles / Endothelial cells / Shear stress / マイクロフィラメント束 / 超音波ドプラー法 / すり応力 / ER stress / apoptosis / heart failure / proteasome / ubiquitin / 小胞体ストレス / アポトーシス / プロテアソーム / ユビキチン / zebrafish / cardiotonic drug / contraction-excitation coupling / drug discovery / Growth Factor / Heart Failure / ゼブラフィッシュ / 強心剤 / 興奮収縮連関 / 創薬 / 増殖因子 / HSP27 / p38MAPキナーゼ / 心保護作用 / J-WIND試験 / プロテインキナーゼA / プロテインキナーゼC / Rhoキナーゼ / 一酸化窒素(NO) / autonomic function / exercise test / virtual reality / the bedside wellness system / バーチャルリアリティ / バーチャルリアリティー / 自律神経 / 運動負荷 / 仮想環境 / ベットサイドウエルネスシステム / cDNAマイクロアレイ / renin-angiotensin system / fibrosis / hypertrophy / hypertension / isolated diastolic heart failure / レニン・アンジオテンシン系 / 線維化 / 高血圧 / 拡張不全 / Cardiomyopathic BIO 14.6 Syrian hamster / long term survival / chronic heart failure / exercise training / 心筋症ハムスタ- / 運動耐溶能 / 生命予後 / 運動負荷試験 / 6-blocker療法 / 心筋症ハムスター / 長期生命予後 / 心筋症ハムスターBIO14.6 / 運動療法 / Clinical Trial / Cathecolamine / Cardioprotection / Stunning / Myocardial Infarction / protcin kinascC / prcconditioning現象 / 遺伝子導入 / ccto-5^I-nuclcotidasc / 虚血・再潅流 / 臨床試験 / トランスジェニックマウス / カテコラミン / アデノシン産生酵素 / 心筋保護 / スタニング / Chronic Heart Failure / Adenosine Receptor Antagonists / cDNA array / Acute Myocardial Infarction / 遺伝子発現ラット / ccto-5´-nuclcotidase / 運動耐容能 / 左室駆出率 / アデノシン産生増強薬 / ecto-5' nucleotidase / アデノシン受容体遮断薬 / DNAmicroarray / ecto-5'-nuclotidase / Perfusion / Contrast / Circulation / Ischemic Heart Disease / 気泡 / 造影剤 / 循環 / 弗素化合物 / angiotensin, angiotensin converting enzyme inhibitor / nitric oxide / reperfusion injury / ACE阻害薬 / ACE活性 / レニン-アンジオテンシン系 / アンジオテンシン変換酵素阻害薬 / アンジオテンシン / 一酸化窒素 / 再潅流障害 / Tissue characterization / Myocardium / 組織性状診断 / 心筋 / culture cell / K^+ channel opener / sulfonylurea receptor / cloning / smooth muscle / heart / ATP-sensitive potassium channels / G蛋白 / NDP / K_<ATP>チャネル / パッチクランプ / cDNA / スルフォニルウレア / ATP感受性チャネル / チャネル / カリウム / スルフオニル尿素受容体 / 培養細胞 / カリウムチャネルオープナ- / スルフォニル尿素受容体 / クローニング / 平滑筋 / 心臓 / ATP感受性カリウムチャネル / calcium / image analysis / gene expression / Cardiac myocyte / フォトン / 混合培養 / 内皮細胞 / カルシウム / 画像解析 / alpha1-adrenoceptor. / ischemic preconditioning. / adenosine. / 虚血・再潅流障害 / α_1アドレナリン受容体 / 5′-nucleotidase / ischemic preconditioning / antisense oligodeoxyribonucleotides / tolerance to ischemia / alpha adrenergic stimulation / hypoxia / アンチセンスオリゴヌクレオチド / α1‐アドレナリン刺激 / アンセチンスオリゴヌクレオチド / マンガンスーパーオキシドジスムターゼ / 虚血耐性 / a1-アンドレナリン刺激 / 低酸素 / Gap junction / Intercalated disc / Low molecuar weight G-protein / Heart failure / Myocardial injury / Calcium signaling / Adhesion molecule / カルシウム遊離チャネル / アラキドン酸 / カルシウムポンプ / ホスホランバン / 病態生理学 / ギャップ結合 / 介在板 / 低分子量G蛋白質 / 再灌流 / 心筋細胞障害 / カルシウムシグナリング / 接着分子 / Intimal Lesions / Hypercholesterolemia / Microfilaments / Endothelial Cells / Doppler Velocimeter / Atherosclerosis / hypercholesterolemia / endothelial cells / 内膜病変 / 高脂血症 / マイクロフィラメント / 超音波ドプラ法 / 強磁場 / 機能的指標 / 形態的指標 / 環境因子 / 細胞障害 / 培養 / プロコラーゲンタイプIIIペプチド / コラーゲン代謝 / リモデリング / 心塞瘤 / BNP / ANP / アドレノメデュリン / アンジオテンシンII / エンドセリン / 細胞内情報伝達 / G protein / Angiotensin II / endothelin / adrenomedulin / calcium ion / signal transduction / mechanical stress / cardiomyocytes / 動脈硬化症 / 左心室壁運動異常 / デジタルサブトラクションエコグラフィ- / 心蔵超音波 / 左室壁運動異常 / デジタル・サブトラクション・エコグラフィー / 酸化的ストレス / 培養血管内皮細胞 / cardiomyopa thy / micro circulation / coronary circulation / Doppler echocardiography Less

Development of Single Nucleotide Polymorphism Based Tailor Made Therapy in Patients with Acute Myocardial InfarctionPrincipal Investigator
- Principal Investigator
  
  SATO Hiroshi, 堀正二
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
New therapeutic approach for heart failure using HB-EGF mediated signal transduction
- Principal Investigator
  
  TAKASHIMA Seiji
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
The role of ER stress and ubiquitin-proteasome system in the development of heart failrue
- Principal Investigator
  
  MINAMINO Tetsuo
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
Experimental and clinical evaluation of cardioprotective effects by adenosine and nitric oxidePrincipal Investigator
- Principal Investigator
  
  HORIO Masatsugu
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
心不全治療の新しい標的としての増殖因子HB-EGFPrincipal Investigator
- Principal Investigator
  
  堀正二
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
The Identification of Cardioprotective Mechanism Afforded by Ischemic Preconditioning and its Application to the Therapy Against Acute Myocardial Infarction
- Principal Investigator
  
  SATO Hiroshi, 佐藤秀幸
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
Acquirement of the Ischemic Cardioprotection and ecto-5'-nucleotidase : Investigation of the Receptor Activation and Subsequent Signal Transduction
- Principal Investigator
  
  MASUYAMA Tohru, 北風政史
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
The effect of bedside wellness system on the autonomic, hormonal function and exercise tolerance in healthy subjects
- Principal Investigator
  
  SATO Hiroshi
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
Cardiac stress-responsive mechanism and its theraprutic applicationPrincipal Investigator
- Principal Investigator
  
  HORI Masatsugu
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (A).
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
Molecular epidemiology of acute coronary syndrome in Japan : Large-scale, prospective, multicenter clinical investigationPrincipal Investigator
- Principal Investigator
  
  HORI Masatsugu
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for University and Society Collaboration
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
Development and Establishment of a New Therapeutic Strategy for Chronic Heart Failure due to Adenosine.
- Principal Investigator
  
  KITAKAZE Masafumi
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
Prevention of atherosclerotic plaque rupture by the regulation of oxygen radical metabolism of vascular wall cells.Principal Investigator
- Principal Investigator
  
  HORI Masatsugu
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
Molcular Mechanisms and Clinical Role of the Phosphorylation and Activation of Ecto-5'-Nucleotidase, Adenosine Producing Enzyme in Cardioprotection.
- Principal Investigator
  
  KITAKAZE Masafumi
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
Effects of exercise trainig and long-Term Survival in the BIO 14.6 cardiomyopathic Hamsters with chronic heart failure.
- Principal Investigator
  
  SATO Hideyuki
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
Examination of the mechanism of the transition to isolated diastolic heart failure
- Principal Investigator
  
  MASUYAMA Tohru
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
Efficacy of Intravenous Ultrasonic Contrast Agent for Diagnosing Ischemic Heart Disease.
- Principal Investigator
  
  BEPPU Shintaro
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
Role of atherosclerosis on myocardial infarction -cross talk of renine-angiotensis system and nitric oxide-
- Principal Investigator
  
  NISHIDA Masashi, 星田四郎
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
The pathophysiological significanse and mechanism of activation of key enzyme responsible for adenosine production in ischemic preconditioning.Principal Investigator
- Principal Investigator
  
  HORI Masatsugu
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
Development of real-time two-dimensional ultrasonic myocardial tissue characterization to assess myocardial molecular characteristics.
- Principal Investigator
  
  TAKEDA Hiroshi, 井上通敏
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
Development of in vitro reconstituted system for investigating intracellular signal trasduction and cellular function in myocardial cellsPrincipal Investigator
- Principal Investigator
  
  HORI Masatsugu
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
心筋細胞の刺激受容機構とシグナル伝達系
- Principal Investigator
  
  矢崎義雄
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
急性心筋梗塞後の治癒過程と左室リモデリング-血中プロコラーゲンタイプIIIペプチドの意義-
- Principal Investigator
  
  KORETSUNE Yukihiro
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
Molecular cloning of ATP-sensitive K^+ channels and development of the method evaluating K^+ channel openers.
- Principal Investigator
  
  KURACHI Yoshihisa
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
Role of Calcium Signaling Pathway for Cardiac Cell Injury
- Principal Investigator
  
  TADA Michihiko
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
The Mechanism of the acquisition of tolerance to cardiac ischemia - the role of oxygen radical scavengers -
- Principal Investigator
  
  KUZUYA Tsunehiko
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
Cardioprotective effect of adenosine in ischemia and reperfusion injury
- Principal Investigator
  
  INOUE Michitoshi
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
Development of image analyze systems of gene expression in co-cultured cells
- Principal Investigator
  
  KUZUYA Tsunehiko
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
Role of calcium overload on coronary arterial stunning caused by myocardial ischemia reperfusionPrincipal Investigator
- Principal Investigator
  
  HORI Masatsugu
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
培養内皮細胞を用いた動脈硬化発症・進展における血流の関与の解明
- Principal Investigator
  
  田内潤
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
超音波断層法の変位検出能と超高精度化する高速度超音波基分法(HsDSE)の開発
- Principal Investigator
  
  田内潤
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (A)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
Cardioprotective roles of adenosine against ischemic and reperfusion injuryPrincipal Investigator
- Principal Investigator
  
  HORI Masatsugu
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
高速フ-リエ変換・ドプラ-カテ-テルによる不全心の冠血流・微小循環障害の解析
- Principal Investigator
  
  TANOUCHI Jun
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
A Study on the Interrelations of the Hemodynamics and the Vascualr Endothelial Ultrastructure and Function
- Principal Investigator
  
  INOUE Michitoshi
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
Role of Adrenergic Activity, Alpha-Receptor, and Beta-Receptor in Progression of Chronic Heart FailurePrincipal Investigator
- Principal Investigator
  
  HORI Masatsugu
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University, School of Medicine
A study on the dynamics of intracellular calcium ion in myocardium of isolated, perfused hearts during ischemia and after reperfusion.
- Principal Investigator
  
  KUSUOKA Hideo
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
Role of Neurohumoral Abnormalities and -Adrenergic Reeptor Changes in Progression of Chronic Heart FailurePrincipal Investigator
- Principal Investigator
  
  HORI Masatsugu
- Project Period (FY)
  1987 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
培養心筋細胞による各種環境要因の生体影響評価モデルの開発研究
- Principal Investigator
  
  武田裕
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for Environmental Science
- Research Institution
  Osaka University
Relation between wall shear stress in vivo and microfilament buncles in vascular endothelial cells.
- Principal Investigator
  
  KITABATAKE Akira
- Project Period (FY)
  1986 – 1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University

All 2009 2008 2007 2006 2005 2004 Other

All Journal Article Book Patent

[Book] 循環器疾患最新の治療2008
- Author(s)
  堀正二
- Total Pages
  561
- Publisher
  南江堂
- Data Source
  KAKENHI-PROJECT-19390215
[Book]
- Author(s)
  堀正二 : 循環器疾患最新の治療.南江堂2008年総561頁
- Data Source
  KAKENHI-PROJECT-19390215
[Journal Article] SNPs in BRAP associated with risk of myocardial infarction in Asian populations2009
- Author(s)
  Ozaki K, Sato H, Inoue K, Tsunoda T, Sakata Y, Mizuno H, Lin TH, Miyamoto Y, Aoki A, Onouchi Y, Sheu SH, Ikegawa S, Odashiro K, Nobuyoshi M, Juo SH, Hori M, Nakamura Y, Tanaka T.
- Journal Title
  
  Nat Genet 41(3)(Epub)
  
  Pages: 329-33
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390215
[Journal Article] Lymphotoxin-alpha3 mediates monocyte-endothelial interaction by TNFR I/NF-kappaB signaling2009
- Author(s)
  Suna S, Sakata Y, Shimizu M, Nakatani D, Usami M, Matsumoto S, Mizuno H, Ozaki K, Takashima S, Takeda H, Tanaka T, Hori M, Sato H.
- Journal Title
  
  Biochem Biophys Res Commun 379(2)(Epub)
  
  Pages: 374-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390215
[Journal Article] Impact of Diabetes Mellitus on Rehospitalization for Heart Failure Among Survivors of Acute Myocardial Infarction in the Percutaneous Coronary Intervention Era2009
- Author(s)
  Nakatani D, Sakata Y, Mizuno H, Shimizu M, Suna S, Usami M, Ito H, Yasumura Y, Hirayama A, Takeda H, Hori M, Sato H
- Journal Title
  
  the Osaka Acute Coronary Insufficiency Study (OACIS) Group. Circ J. 73(4)(Epub)
  
  Pages: 662-666
- NAID
  10025929227
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390215
[Journal Article] Up-regulation of cell adhesion molecule genes in human endothelial cells stimulated by lymphotoxin alpha : DNA microarray analysis2008
- Author(s)
  Suna S, Sakata Y, Sato H, Mizuno H, Nakatani D, Shimizu M, Usami M, Takashima S, Takeda H, Hori M. J
- Journal Title
  
  Atheroscler Thromb 15(3)
  
  Pages: 160-5
- NAID
  10022608417
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390215
[Journal Article] Effect of early use of low-dose pravastatin on major adverse cardiac events in patients with acute myocardial infarction : the OACIS-LIPID Study2008
- Author(s)
  Study. Sato H, Kinjo K, Ito H, Hirayama A, Nanto S, Fukunami M, Nishino M, Lim YJ, Kijima Y, Koretsune Y, Nakatani D, Mizuno H, Shimizu M, Hori M
- Journal Title
  
  M ; Osaka Acute Coronary Insufficiency Study (OACIS)-LIPID Study Investigators. Circ J. 72(1)
  
  Pages: 17-22
- NAID
  110006533907
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390215
[Journal Article] Effect of intracoronary thrombectomy on 30-day mortality in patients with acute myocardial infarction2007
- Author(s)
  Nakatani D, Sato H, Sakata Y, Mizuno H, Shimizu M, Suna S, Nanto S, Hirayama A, Ito H, Fujii K, Hori M.
- Journal Title
  
  Am J Cardiol 100(8)(Epub)
  
  Pages: 1212-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390215
[Journal Article] A Novel Cardiac Myosin Light Chain Kinase Regulates Sarcomere Assembly in the Vertebrate Heart.2007
- Author(s)
  Osamu Seguchi, Seiji Takashima, Satoru Yamazaki, Masanori Asakura, Yoshihiro Asano, Yasunori Shintani, Masakatsu Wakeno, Tetsuo Minamino, Hiroya Kondo, Hidehiko Furukawa, Kenji Nakamaru, Asuka NaitoTomoko Takahashi, Toshiaki Ohtsuka, Koichi Kawakami, Tadashi Isomura, Soichiro Kitamura, Hitonobu Tomoike, Naoki Mochizuki, Masafumi Kitakaze
- Journal Title
  
  J. of Clin.Invest. (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390229
[Journal Article] Prolonged transient acidosis during early reperfusion contributes to the cardioprotective effects of postconditioning.2007
- Author(s)
  Fujita M, Asanuma H, Hirata A, Wakeno M, Takahama H, Sasaki H, Kim J, Takashima S, Tsukamoto O, Minamino T, Shinozaki Y, Tomoike H, Hori M, Kitakaze M.
- Journal Title
  
  Am J Physiol Heart Circ Physiol. 292(4)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590731
[Journal Article] S-nitrosylated and pegylated hemoglobin, a newly developed artificial oxygen carrier, exerts cardioprotection against ischemic hearts.2007
- Author(s)
  Asanuma H, Nakai K, Sanada S, Minamino T, Takashima S, Ogita H, Fujita M, Hirata A, Wakeno M, Takahama H, Kim J, Asakura M, Sakuma I, Kitabatake A, Hori M, Komamura K, Kitakaze M.
- Journal Title
  
  J Mol Cell Cardiol. (In press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590731
[Journal Article] A functional SNP in ITIH3 is associated with susceptibility to myocardial infarction2007
- Author(s)
  Ebana Y, Ozaki K, Inoue K, Sato H, Iida A, Lwin H, Saito S, Mizuno H, Takahashi A, Nakamura T, Miyamoto Y, Ikegawa S, Odashiro K, Nobuyoshi M, Kamatani N, Hori M, Isobe M, Nakamura Y, Tanaka T.
- Journal Title
  
  J Hum Genet 52(3)(Epub)
  
  Pages: 220-9
- NAID
  10018554093
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390215
[Journal Article] Effect on outcome of an increase of serum cardiac troponin T in patients with healing or healed ST-elevation myocardial infarction2007
- Author(s)
  Shimizu M, Sato H, Sakata Y, Nakatani D, Mizuno H, Suna S, Fujii K, Ueda Y, Nanto S, Hori M
- Journal Title
  
  Osaka Acute Coronary Insufficiency Study (OACIS) Group. Am J Cardiol 100(12)(Epub)
  
  Pages: 1723-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390215
[Journal Article] Clinical impact of metabolic syndrome and its additive effect with smoking on subsequent cardiac events after acute myocardial infarction2007
- Author(s)
  Nakatani D, Sakata Y, Sato H, Mizuno H, Shimizu M, Suna S, Ito H, Koretsune Y, Hirayama A, Hori M
- Journal Title
  
  Osaka Acute Coronary Insufficiency Study (OACIS) Group. Am J Cardiol 99(7)(Epub)
  
  Pages: 885-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390215
[Journal Article] Erythropoietin enhances neovascularization of ischemic myocardium and improves left ventricular dysfunction after myocardial infarction in dogs.2006
- Author(s)
  Hirata A, Minamino T, Asanuma H, Fujita M, Wakeno M, Myoishi M, Tsukamoto O, Okada K, Koyama H, Komamura K, Takashima S, Shinozaki Y, Mori H, Shiraga M, Kitakaze M, Hori M.
- Journal Title
  
  J Am Coll Cardiol. 48(1)
  
  Pages: 176-84
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590731
[Journal Article] The antagonism of aldosterone receptor prevents the development of hypertensive heart failure induced by chronic inhibition of nitric oxide synthesis in rats.2006
- Author(s)
  Tsukamoto, O., Minamino, T., Sanada, S., Okada, K., Hirata, A., Fujita, M., Shintani, Y., Yulin, L., Asano, Y, Takashima, S., Yamasaki, S., Tomoike, H., Hori, M., Kitakaze, M.
- Journal Title
  
  Cardiovasc Drugs Ther 20
  
  Pages: 93-102
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390229
[Journal Article] Glycosaminoglycan modification of neuropilin-1 modulates VEGFR2 signaling.2006
- Author(s)
  Shintani, Y., Takashima, S., Asano, Y., Kato, H., Liao, Y., Yamazaki, S., Tsukamoto, 0., Seguchi, O., Yamamoto, H., Fukushima, T., Sugahara, K., Kitakaze, M., Hori, M.
- Journal Title
  
  Embo J 25
  
  Pages: 3045-55
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390229
[Journal Article] A calcium channel blocker amlodipine ircreases coronary blood flow via both adenosine- and NO-dependent mechanisms in ischemic hearts.2005
- Author(s)
  Asanuma Hiroshi
- Journal Title
  
  J Mol Cell Cardiol 39
  
  Pages: 605-614
- Data Source
  KAKENHI-PROJECT-17590731
[Journal Article] A calcium channel blocker amlodipine increases coronary blood flow via both adenosine-and NO-dependent mechanisms in ischemic hearts.2005
- Author(s)
  Asanuma Hiroshi
- Journal Title
  
  J Mol Cell Cardiol 39
  
  Pages: 605-614
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390225
[Journal Article] Beta-adrenoceptor blocker carvedilol provides cardioprotection via an adenosine-dependent mechanism in ischemic canine hearts.2004
- Author(s)
  Asanuma Hiroshi
- Journal Title
  
  Circulation 109
  
  Pages: 2773-2779
- Data Source
  KAKENHI-PROJECT-16390225
[Journal Article] Methotrexate and MX-68, a new derivative of methotrexate, limit infarct size via adenosine-dependent mechanisms in canine hearts.2004
- Author(s)
  Asanuma Hiroshi
- Journal Title
  
  J Cardiovasc Pharmacol 43
  
  Pages: 574-579
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390225
[Journal Article] Methotrexate and MX-68, a new derivative of methotrexate, limit infarct size via adenosine-dependent mechanisms in canine hearts2004
- Author(s)
  Asanuma Hiroshi
- Journal Title
  
  J Cardiovasc Pharmacol 43
  
  Pages: 574-579
- Data Source
  KAKENHI-PROJECT-16390225
[Journal Article] Beta-adrenoceptor blocker carvedilol provides cardioprotection via an adenosine- dependent mechanism in ischemic canine hearts.2004
- Author(s)
  Asanuma Hiroshi
- Journal Title
  
  Circulation 109
  
  Pages: 2773-2779
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390225
[Journal Article] Beta-adrenoceptor blocker carvedilol provides cardioprotection via an adenosine-dependent mechanism in ischemiccaninehearts.2004
- Author(s)
  Asanuma Hiroshi
- Journal Title
  
  Circulation 109
  
  Pages: 2773-2779
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390225
[Patent] 心不全の判定方法2006
- Inventor(s)
  南野哲男, 堀正二, 岡田健一郎, 北風政史
- Industrial Property Rights Holder
  国立大学法人大阪大学, 財団法人ヒューマンサイエンス振興財団
- Industrial Property Number
  2006-016514
- Filing Date
  2006-01-25
- Data Source
  KAKENHI-PROJECT-17590731

1. KUZUYA Tsunehiko (80150340)

# of Collaborated Projects: 15 results

# of Collaborated Products: 0 results
2. KITAKAZE Masafumi (20294069)

# of Collaborated Projects: 14 results

# of Collaborated Products: 6 results
3. INOUE Michitoshi (30028401)

# of Collaborated Projects: 11 results

# of Collaborated Products: 0 results
4. SATO Hiroshi (10294092)

# of Collaborated Projects: 11 results

# of Collaborated Products: 9 results
5. SATO Hideyuki (70167435)

# of Collaborated Projects: 9 results

# of Collaborated Products: 0 results
6. TADA Michihiko (90093434)

# of Collaborated Projects: 8 results

# of Collaborated Products: 0 results
7. MASUYAMA Tohru (70273670)

# of Collaborated Projects: 8 results

# of Collaborated Products: 0 results
8. TAKEDA Hiroshi (20127252)

# of Collaborated Projects: 8 results

# of Collaborated Products: 0 results
9. NISHIDA Masashi (40283783)

# of Collaborated Projects: 7 results

# of Collaborated Products: 0 results
10. KORETSUNE Yukihiro (50243217)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
11. TANOUCHI Jun (20197544)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
12. KITABATAKE Akira (00124769)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
13. HOSHIDA Shiro (80238732)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
14. TAKASHIMA Seiji (90379272)

# of Collaborated Projects: 4 results

# of Collaborated Products: 6 results
15. MIYAZAKI Jun-ichi (10200156)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
16. MINAMINO Tetsuo (30379234)

# of Collaborated Projects: 4 results

# of Collaborated Products: 5 results
17. TOYOFUKU Toshihiko (60322179)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
18. KUSUOKA Hideo (00112011)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
19. OHTSU Kin-ya (20294051)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
20. CHIHARA Kunihiro (80029561)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
21. BEPPU Shintaro (40113500)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
22. MATSUMURA Yasushi (90252642)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
23. ISHIHARA Ken (20304610)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
24. 近藤寛也 (40294102)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
25. UEMATSU Masaaki

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
26. SAKATA Yasuhiko (90379206)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
27. ENDO Masao (40004668)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. TSUKITA Shoichiro (50155347)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. TOYAMA Junji (20023658)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. KURACHI Yoshihisa (30142011)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. YAMADA Mitsuhiko (10263237)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. TAKUMI Toru (00222092)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. FUJIWARA Keigi (10190092)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
34. YONEDA Yoshihiro (80191667)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
35. ISHIKURA Fuminobu (50303970)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
36. YAMAMOTO Kazuhiro (90303966)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
37. MIWA Takeshi (20174229)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
38. ONISHI Shunzo (00028367)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
39. 鎌田武信 (80028399)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
40. 矢崎義雄 (20101090)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
41. 寒川賢治 (00112417)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
42. 高井義美 (60093514)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
43. 横山光宏 (40135794)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
44. 篠山重威 (70109007)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
45. 島津敬 (50178935)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
46. 中馬一郎 (10028269)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
47. 堀尾嘉幸 (30181530)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
48. 高橋尚彦 (30263239)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
49. FUJIMOTO Masao

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
50. KURIHARA Toshinao

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
51. YAMASHITA Nobushige

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
52. DOI Reiko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
53. 鍵谷俊文

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
54. 藤井謙司

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
55. FUJII Kenshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

HORIO Masatsugu 堀 正二

HORI Masatsugu 堀 正二

Research Projects

Research Products

Co-Researchers

Development of Single Nucleotide Polymorphism Based Tailor Made Therapy in Patients with Acute Myocardial InfarctionPrincipal Investigator

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Experimental and clinical evaluation of cardioprotective effects by adenosine and nitric oxidePrincipal Investigator

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心不全治療の新しい標的としての増殖因子HB-EGFPrincipal Investigator

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Cardiac stress-responsive mechanism and its theraprutic applicationPrincipal Investigator

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Molecular epidemiology of acute coronary syndrome in Japan : Large-scale, prospective, multicenter clinical investigationPrincipal Investigator

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Prevention of atherosclerotic plaque rupture by the regulation of oxygen radical metabolism of vascular wall cells.Principal Investigator

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HORIO Masatsugu 堀正二

HORI Masatsugu 堀正二