KOKAI Yasuo 小海康夫

… Alternative Names

小海康夫コカイヤスオ

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Researcher Number	20178239
Other IDs
External Links
Affiliation (Current)	2025: 札幌医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2003 – 2023: 札幌医科大学, 医学部, 教授 2017: 札幌医科大学, 医学部・フロンティア医学研究所, 教授 2000 – 2001: Department of Pathology Sapporo Medical University School of Medicine, 医学部, 助教授 1998 – 1999: 札幌医科大学, 医学部, 助手 1997 – 1999: Sapporo Medical University School of Medicine, Department of Pathology Assistant, 医学部, 講師 … More 1996: 札幌医科大学, 医学部, 助手 1995: National Children's Medical Research Center, Department of Pathology, Laboratory Chief, 病理学教室, 助手 1992: 国立小児病院小児医療研究センター, 病理, 室長 Less
Review Section/Research Field	Principal Investigator Cell biology / Experimental pathology / Basic Section 49030:Experimental pathology-related / Otorhinolaryngology / Pain science Except Principal Investigator Psychiatric science / Orthopaedic surgery / Basic Section 52030:Psychiatry-related / Metabolomics / Dermatology … More / Human pathology / Orthopaedic surgery / Experimental pathology / General pharmacology / 内分泌・代謝学 / Public health/Health science / Biological Sciences Less
Keywords	Principal Investigator occludin / barmotin / CCL8 / バイオマーカー / 移植片対宿主病 / 造血幹細胞移植 / 分子標的療法 / 根治療法 / 白血病 / barrier … More / tight junction / Barmotin / タイト結合 / プロテオーム / GVHD / ケモカイン / 同種移植 / アロ移植 / ドナー / 組織適合抗原 / 難病根治 / biological molecule / neuroscinece / impaired hearing / proteome / inner ear / プロテーム / 神経科学 / 生体分子 / 内耳 / 難聴 / 神経化学 / H.pylori / connexin 32 / gap junction / Tight junction / 疾患 / フェンス / バリア / アクチン / バーモチン / 7H6 / 細胞バリア / PDZ domein / Mid body / claudin / actin / cancer / zo-1 / oclcudin / 生体防御 / SMC / 分子モーター / 生体バリア / ZO-1 / 分子病理学 / ヒト大腸癌 / Two hybrid / バリア機能 / 神経成長因子 / 情報科学 / プロテオミクス / 分子パスウエイ / 神経因性疼痛 / 外傷 / 酸化ストレス / メタロチオネイン / CRPS / 慢性複合性疼痛 / 神経障害性疼痛 / トランスレーショナルリサーチ / アレルギー・喘息 / outcome / prognosis / proteomics / serum / plasma / biomarker / 予後予測 / 治療効果判定 / 客観診断 / 再生医学 … More Except Principal Investigator タイト結合 / トランスジェニックマウス / アルツハイマー病 / バイオマーカー / BMP-2 / IL-10 / 糖尿病 / 血漿分子マーカー / MFG-E8 / アネキシンA5 / 血漿バイオマーカー / 認知症 / プロテオミクス / occludin / 細胞電気抵抗 / 差スペクトル / アミロイドβペプチド / 電顕ネガティブ染色法 / 長波長シフト / 吸収スペクトル解析 / エストロゲン / ELISA / レビー小体型認知症 / Ca2+ストレス / Congo Red / アミロイド / 遺伝子 / 食品 / 栄養学 / ヘモグロビンA1c / フコキサンチン / UCP1遺伝子多型 / neuronal cell / biomarker / plasma / proteomics / annexin A5 / Ca^<2+>-stress / Alzheimer's disease / dementia / 酸化的ストレス / 血漿マーカー / リポソーム / プロテオミックス / カルシウムストレス / アミロイドβ / 神経細胞障害 / CS^<2+>-ストレス / 神経細胞 / 血漿 / Cs^<2+>-ストレス / Rab7 / Transgenic mouse / Pigmentation Disorder / GTP-binding protein / Transgene / Melanocyte / Melanosome / Melanin / Rab蛋白 / 低分子G蛋白 / トランスジーン / GTP結合蛋白 / 色素異常症 / メラノソーム / 分泌蛋白生合成 / 色素細胞 / 小胞輸送 / メラニン / メラノサイト / carcinoma / immunohistochemistry / neoplasm / tight junction / 不妊症 / 癌 / 免疫組織化学 / Occludin / 腫瘍 / lung adenocarcinoma / Toll-like receptor / osteoblasts / osteoclasts / transgenic mice / osteoporosis / G-CSF / Bone morphogenic protein / 骨形成 / 骨量 / 卵巣摘除 / CFU-GM / 骨芽細胞 / 破骨細胞 / 骨粗鬆症 / 顆粒球コロニー刺激因子 / Molecular pathology / Cell to cell communication / Cholestasis / Enteropathy / Barrier function / Motor protein / Tight junction / 細胞接着装置 / 転移抑制 / 染色体凝集 / 7H6抗原 / ギャップ結合 / 細胞接着 / 分子モーター / バリアー調節因子 / バリアー機能 / 分子病理学 / 閉塞性黄疸 / 細胞間物質透過 / 異型性 / 細胞極性 / ヒト大腸癌 / バリア機能 / diabetic complications / gene targeting / aldose reductase / 酵素欠失マウス / 糖尿病合併症 / ジーンターゲティング / アルドース還元酵素 / paracrine secretion / lymphocytes / cytokine / IDDM / deabetes / pancreatic islet B-cell / gene therapy / レトロウィルスベクター / Tリンパ球 / インターフェロンγ / インターロイキン10 / 自己免疫疾患 / リンパ球 / サイトカイン / I型糖尿病 / 膵ラ島B細胞 / 遺伝子治療 / 日本人 / リスクテスト / 高血圧 / 肥満 / インスリンパワー / インスリン抵抗性 / インスリン分泌能 / リスク予測 / ２型糖尿病 / 健康管理 / Ca^<2+>ホメオスタシス / ROC曲線 / プロテオミクス解析 / プロテオーム解析 / 神経腫 / 発痛 / 断端神経腫 / CRPS / 神経再生 / 神経因性疼痛 / 神経損傷 / 疼痛 / 再生 / 末梢神経 / galanin / CGRP / 疼痛関連遺伝子 / Na+チャネル / マイクログリア / ノルエピネフリン / パッチクランプ / 集学的アプローチ / 慢性腰痛 / 脊髄膠様質 / 神経根絞扼モデル / 神経根性疼痛 / 集学的治療 / 脊髄膠様質細胞 / 神経ペプチド / グリア細胞 / 交感神経 / 後根神経節 / 慢性疼痛 / 運動器 / cyclin D1 / melanocortin receptor / epidemiology / transcription factor / melanoma / Min mouse / SMC蛋白 / 7H6(barmotin) / ZO-1 Less

Investigation of a novel amylodotic biomarker for alzheimer disease
- Principal Investigator
  
  Sohma Hitoshi
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Sapporo Medical University
Identification and molecular dissection of pathological mechanisms in tissue injury of graft-versus-host diseasePrincipal Investigator
- Principal Investigator
  
  小海康夫
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Sapporo Medical University
Identification and molecular dissection of pathological mechanisms in tissue injury of graft-versus-host diseasePrincipal Investigator
- Principal Investigator
  
  Kokai Yasuo
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Sapporo Medical University
Reduction of HbA1c levels by fucoxanthin on UCP1 gene polymorphism
- Principal Investigator
  
  Mikami Nana
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Metabolomics
- Research Institution
  Sapporo Medical University
A fundamental study aiming development of molecular diagnosis for neuropathic painPrincipal Investigator
- Principal Investigator
  
  Kokai Yasuo
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Pain science
- Research Institution
  Sapporo Medical University
Risk prediction for type 2 diabetes and application for counseling guidance by insulin power health examination in a Japanese population
- Principal Investigator
  
  SATA Fumihiro
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Public health/Health science
- Research Institution
  National Institute of Public Health
Fundamental study of patholofgival role of CCL8 in GVHDPrincipal Investigator
- Principal Investigator
  
  KOKAI Yasuo
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Sapporo Medical University
Identification of biomarkers for differential diagnosis of neurodegenerative and non-neurodegenerative dementia
- Principal Investigator
  
  SOHMA Hitoshi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  Sapporo Medical University
Study of mechanism and treatment of chronic musculoskeletal pain.
- Principal Investigator
  
  YAMASHITA Toshihiko
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Sapporo Medical University
ヒト断端神経腫のプロテオミクス解析による神経因性疼痛の発症因子の解明
- Principal Investigator
  
  WADA Takuro
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Sapporo Medical University
STUDY OF THE MECHANISM OF NEURONAL CELL DAMAGE IN DEMENTIA FOR EARLY DIAGOSIS
- Principal Investigator
  
  SOHMA Hitoshi
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  Sapporo Medical University
Identification of inner ear specific protein binds to connexin 26Principal Investigator
- Principal Investigator
  
  KOKAI Yasuo
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Sapporo Medical University
メラノーマの病型と進展・予後制御分子の臨床疫学
- Principal Investigator
  
  JIMBOW Kowichi
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Sapporo Medical University
Failure of vesicular transport and development of multi-organ defects through acidic melanosomal and lysosomal granules
- Principal Investigator
  
  JIMBOW Kowichi
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Dermatology
- Research Institution
  Sapporo Medical University
Immunohistochemical analyses of occludin expression in human diseases and their application for diagnostic pathology
- Principal Investigator
  
  TOBIOKA Hirotoshi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Sapporo Medical University
MOLECULAR ANALYSIS OF CELL BARRIER ASSOCIATED PROTEIN BARMOTIN (7H6 ANTIGEN)Principal Investigator
- Principal Investigator
  
  KOKAI Yasuo
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cell biology
- Research Institution
  SAPPORO MEDICAL UNIVERSITY SCHOOL OF MEDICINE
血管内皮細胞のタイト結合蛋白と癌転移
- Principal Investigator
  
  澤田典均
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Sapporo Medical University
Study on the effect of colony stimulating factor on bone metabolism
- Principal Investigator
  
  WADA Takuro
- Project Period (FY)
  1998 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Sapporo Medical University
血管内皮細胞のタイト結合蛋白7H6とがん細胞の血管外脱出の抑制
- Principal Investigator
  
  SAWADA Norimasa
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Sapporo Medical University
MOLECULAR MAPPING OF TIGHT JUNCTION PROTEINS WITH RECOMBINANT 7H6 POLYPEPTIDEPrincipal Investigator
- Principal Investigator
  
  KOKAI Yasuo
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cell biology
- Research Institution
  SAPPORO MEDICAL UNIVERSITY SCHOOL OF MEDICINE
Molecular pathology of tight junctions-with special reference to the biological barrier function of the liver and digestive tract-
- Principal Investigator
  
  MORI Michio
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  SAPPORO MEDICAL UNIVERSITY SCHOOL of MEDICINE
Generation of aldose reductase knockout mouse by gene targeting and expression of human enzyme
- Principal Investigator
  
  NISHIMURA Chihiro
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  National Children's Medical Research Center
Development of Gene Therapy for Type I Diabetes Using Cytokine Gene and Pancreatic Islet B Cell-Specific Lymphocytes
- Principal Investigator
  
  ITAKURA Mitsuo
- Project Period (FY)
  1992 – 1994
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  内分泌・代謝学
- Research Institution
  The University of Tokishima

[Book] Update on Dementia2016
- Author(s)
  Sohma H, Kokai Y.
- Total Pages
  546
- Publisher
  INTECH
- Data Source
  KAKENHI-PROJECT-16K08743
[Book] 臨床整形外科：メタロチオネインは神経障害性疼痛の発生を抑制する2013
- Author(s)
  大木豪介、和田卓郎、藤田安詞、山下敏彦、今井伸一、小海康夫
- Total Pages
  5
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-25670286
[Journal Article] MFG-E8, A Novel Biomarker for Alzheimer’s Disease and Its Amyloidotic Feature2024
- Author(s)
  Hitoshi Sohma, Michitoshi Kimura, Ayaka Sudo, Mihoko Ohashi, Hiromi Hamano and Yasuo Kokai
- Journal Title
  
  IntechOpen
  
  Volume: 1 Pages: 1-12
- DOI
  10.5772/intechopen.1002658
- ISBN
  9780854660865, 9780854660858
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07975
[Journal Article] Reveromycin A inhibits bone loss in ovariectomized mice2019
- Author(s)
  Ozasa Y, Wada T, Yamashita T, Kokai Y.
- Journal Title
  
  J Surg Res
  
  Volume: 2 Pages: 087-095
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07484
[Journal Article] Early expression of serum CCL8 closely correlates to non-relapse mortality after allogeneic hematopoietic stem cell transplantation.2018
- Author(s)
  Yamamoto M, Hori T, Igarashi K, Kokai Y et al
- Journal Title
  
  Sapporo Medical Journal
  
  Volume: 86 Pages: 45-51
- NAID
  120006488957
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08743
[Journal Article] Early expression of serum CCL8 closely correlates to non-relapse mortality after allogeneic hematopoietic stem cell transplantation.2018
- Author(s)
  Yamamoto M, Hori T, Hatakeyama N, Igarashi K, Inazawa N, Suzuki N, Takei N, Ito Y-M, Matsumoto K, Kato K, Tsutsumi H, Kokai Y.
- Journal Title
  
  Sapporo Med J
  
  Volume: 86 Pages: 45-51
- NAID
  120006488957
- Data Source
  KAKENHI-PROJECT-16K08743
[Journal Article] Reduction of HbA1c levels by fucoxanthin-enriched akamoku oil possibly involves the thrifty allele of uncoupling protein 1 (UCP1): a randomised controlled trial in normal-weight and obese Japanese adults2017
- Author(s)
  Nana Mikami, Masashi Hosokawa, Kazuo Miyashita, Hitoshi Sohma, Yoichi M. Ito, Yasuo Kokai
- Journal Title
  
  Journal of Nutritional Science
  
  Volume: 6
- DOI
  10.1017/jns.2017.1
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K21251
[Journal Article] HLA-A24 ligandome analysis of colon and lung cancer cells identifies a novel cancer-testis antigen and a neoantigen that elicits specific and strong CTL responses.2017
- Author(s)
  Kochin V, Kanaseki T, Tokita S, Miyamoto S, Shionoya Yo, Kikuchi Y, Morooka D, Hirohashi Y, Tsukahara T, Watanabe K, Toji S, Kokai Y, Sato N, Torigoe T.
- Journal Title
  
  Oncoimmunology
  
  Volume: 6 Issue: 4 Pages: 1-12
- DOI
  10.1080/2162402x.2017.1293214
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08743, KAKENHI-PROJECT-17H01540
[Journal Article] A Protocol for Human Serum Fucoxanthinol Quantitation using LC-MS/MS System2016
- Author(s)
  Nana Mikami, Masashi Hosokawa, Masayuki Abe, Kazuo Miyashita, Hitoshi Sohma, Yasuo Kokai
- Journal Title
  
  Journal of Nutritional Medicine and Diet Care
  
  Volume: 2
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K21251
[Journal Article] Evaluation of annexin A5 as a biomarker for Alzheimer's disease and Dementia with Lewy bodies.2013
- Author(s)
  Sohma H, Imai S, Takei N, Honda H, Matsumoto K, Utsumi K, Matsuki K, Hashimoto E, Saito T, Kokai Y.
- Journal Title
  
  Front Aging Neurosci.
  
  Volume: 5 Pages: 1-7
- DOI
  10.3389/fnagi.2013.00015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659363, KAKENHI-PROJECT-24591686, KAKENHI-PROJECT-24592351
[Journal Article] Evaluation of annexin A5 as a biomarker for Alzheimer's disease and Dementia with Lewy bodies2013
- Author(s)
  Sohma H, Imai S, Takei N, Honda H, Matsumoto K, Utsumi K, Matsuki K, Hashimoto E, Saito T, Kokai Y
- Journal Title
  
  Frontiers in Aging Neuroscience
  
  Volume: 5 Pages: 15-23
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590365
[Journal Article] Metallothionein deficiency in the injured peripheral nerves of complex regional pain syndrome as revealed by proteomics2012
- Author(s)
  Oki G, Wada T, Iba K, Aiki H, Sasaki K, Imai S, Sohma H, Matsumoto K, Yamaguchi M, Fujimiya M, Yamashita T, Kokai Y
- Journal Title
  
  Pain
  
  Volume: 153 Pages: 532-539
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591489
[Journal Article] Metalothionein deficiency in the injured peripheral nerves of complex regional pain syndrome as revealed by proteomics2012
- Author(s)
  Oki G, Wada T, Iba K, Aiki H, Sasaki K, Imai S, Sohm H, Matsumoto K, Yamaguchi M, Fujimiya M, Yamashita T, Kokai Y
- Journal Title
  
  Pain
  
  Volume: 153 Pages: 532-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590365
[Journal Article] Early expression of plasma CCL8 closely correlates with survival rate of acute graft-versus-host disease in mice2011
- Author(s)
  Yamamoto M, Ota A, Hori T, Imai S, Sohma H, Suzuki N, Hatakeyama N, Inazawab N, Ito M-Y, Kimura H, Tsutsumi H, Kokai Y
- Journal Title
  
  Exp Hematol (2011)
  
  Volume: 39(11) Pages: 1101-1112
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590365
[Journal Article] Early expression of plasma CCL8 closely correlates with survival rate of acute graft-versus-host disease in mice2011
- Author(s)
  Yamamoto M, Ota A, Hori T, Imai S, Sohma H, Suzuki N, Hatakeyama N, Inazawa N, Ito YM, Kimura H, Tsutsumi H, Kokai Y
- Journal Title
  
  Exp. Hematol
  
  Volume: 39 Pages: 1101-1112
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591489
[Journal Article] Early expression of plasma CCL8 closely correlates with survival rate of acute graft-versus-host disease in mice2011
- Author(s)
  Yamamoto M, Ota A, Hori T, Imai S, Sohma H, Suzuki N, Hatakeyama N, Inazawab N, Ito M-Y, Kimura H, Tsutsumi H, Kokai Y
- Journal Title
  
  Exp Hematol
  
  Volume: 39(11) Pages: 1101-11112
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590365
[Journal Article] Rab7 is a critical mediator in vesicular transport of tyrosinase-related protein 1 in melanocytes2011
- Author(s)
  Hida T, Sohma H, Kokai Y, Kawakami A, Hirosaki K, Okura M, Tosa N, Yamashita T, Jimbow K
- Journal Title
  
  J. Dermatol
  
  Volume: 38 Pages: 432-441
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591489
[Journal Article] Apolipoprotein E4 Frequencies in a Japanese Population with Alzheimer's Disease and Dementia with Lewy Bodies2011
- Author(s)
  Kobayashi S, Tateno M, Park TW, Utsumi K, Sohma H, Ito YM, Kokai Y, Saito T
- Journal Title
  
  PLoS ONE
  
  Volume: 6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591489
[Journal Article] Activation of glial cells in the spinal cord of a model of lumbar radiculopathy2011
- Author(s)
  Takahata S, Takebayashi T, Terasima Y, Tanimoto K, Wada T, Sohma H, Kokai Y, Yamashita T
- Journal Title
  
  J Orthop Sci
  
  Volume: 16 Pages: 313-320
- NAID
  10029573542
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591489
[Journal Article] Apolipoprotein E4 freauencies in Japanese population with Alzheimer's disease and dementia with Lewy bodies2011
- Author(s)
  Kobayashi S, Tateno M, Woo T, Utsumi K, Sohma H, Ito Y-M, Kokai Y, Saito T
- Journal Title
  
  PLos ONE
  
  Volume: 6(4) Pages: 1-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590365
[Journal Article] Investigation of annexin A5 as a biomarker for Alzheimer's disease using neuronal cell culture and mouse model2010
- Author(s)
  Yamaguchi M, Kokai Y, Imai S, Utsumi K, Matsumoto K, Honda H, Mizue Y, Momma M, Maeda T, Toyomasu S, Ito YM, Kobayashi S, Hashimoto E, Saito S, Sohma H
- Journal Title
  
  J. Neurosci. Res
  
  Volume: 88 Pages: 2682-2692
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591489
[Journal Article] Multiple reaction monitoringをバリデーションに用いた質量分析による血漿バイオマーカー探索システムの検討2009
- Author(s)
  佐々木浩一、小笹泰宏、木村成寿、相馬仁、青島理人、小海康夫
- Journal Title
  
  生物物理化学
  
  Volume: 53 Pages: 1-7
- NAID
  10025707947
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591489
[Journal Article] Upregulation of plasma CCL8 in mouse model of graft-vs-host disease2009
- Author(s)
  Ota A, Yamamoto M, Hori T, Miyai S, Naishiro Y, Sohma H, Maeda M, Kokai Y
- Journal Title
  
  Exp Hematol
  
  Volume: 37 Pages: 525-531
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591489
[Journal Article] Anti-tumor effects of dehydroaltenusin, a specific inhibitor of mammalian DNA polymerase alpha2007
- Author(s)
  Maeda N, Kokai Y, Ohtani S, Sahara H, Kamisuki S, Takahashi S et al.
- Journal Title
  
  BBRC 352
  
  Pages: 390-390
- Data Source
  KAKENHI-PROJECT-18591876
[Journal Article] リポソームをリガンドとして用いた血漿蛋白質のプロテオミクス解析2006
- Author(s)
  木村成寿, 相馬仁, 苗代康可, 小海康夫
- Journal Title
  
  生物物理化学 50
  
  Pages: 231-231
- NAID
  10018441612
- Data Source
  KAKENHI-PROJECT-18591876
[Patent] アミロイドβ神経障害バイオマーカー2010
- Inventor(s)
  小海康夫, 相馬仁, 他
- Industrial Property Rights Holder
  札幌医科大学
- Industrial Property Number
  2010-280331
- Filing Date
  2010-12-16
- Data Source
  KAKENHI-PROJECT-21591489
[Patent] アルツハイマー型認知症の検査方法2010
- Inventor(s)
  小海康夫、相馬仁
- Industrial Property Rights Holder
  札幌医科大学
- Industrial Property Number
  2010-115606
- Filing Date
  2010-05-19
- Data Source
  KAKENHI-PROJECT-21591489
[Patent] アミロイドβ神経障害バイオマーカー2010
- Inventor(s)
  小海康夫、相馬仁、今井伸一、松本圭代、木村成寿
- Industrial Property Rights Holder
  小海康夫、相馬仁、今井伸一、松本圭代、木村成寿
- Industrial Property Number
  2010-280331
- Filing Date
  2010-12-16
- Data Source
  KAKENHI-PROJECT-21591489
[Patent] アルツハイマー型認知症の検査方法2010
- Inventor(s)
  相馬仁、小海康夫
- Industrial Property Rights Holder
  相馬仁、小海康夫
- Industrial Property Number
  2010-115606
- Filing Date
  2010-05-19
- Data Source
  KAKENHI-PROJECT-21591489
[Patent] リポソームをリガンドとして用いた体液タンパク質の解析方法及び体液タンパク質の調整方法2006
- Inventor(s)
  相馬仁, 苗代康可, 小海康夫
- Industrial Property Rights Holder
  北海道
- Industrial Property Number
  2006-193711
- Filing Date
  2006-07-14
- Data Source
  KAKENHI-PROJECT-18591303
[Patent] リボソームをリガンドとした体液タンパク質の解析方法及び体液タンパク質の調製方法2006
- Inventor(s)
  相馬仁苗代康可小海康夫
- Industrial Property Rights Holder
  北海道
- Filing Date
  2006-07-14
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591303
[Patent] リポソームをリガンドとして用いた体液タンパク質の解析方法および体液タンパク質の調整方法2006
- Inventor(s)
  相馬仁, 苗代康可, 小海康夫
- Industrial Property Rights Holder
  北海道
- Industrial Property Number
  2006-193711
- Filing Date
  2006-07-14
- Data Source
  KAKENHI-PROJECT-18591876
[Presentation] 新規アルツハイマー病バイオマーカー候補タンパク質Milk fat globule-EGF factor 8 (MFG-E8) のアミロイド性2022
- Author(s)
  大橋　美帆子、濱野　宏美、小海　康夫、相馬　仁
- Organizer
  日本生化学会北海道支部第59回支部例会
- Data Source
  KAKENHI-PROJECT-20K07975
[Presentation] Host CCl8 deficiency alosishes early mortality of acute graft-versus-host disease in mice.2018
- Author(s)
  Yasuo Kokai
- Organizer
  The 107th Annual meeting of the Japanese Society of Pathology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08743
[Presentation] UCP1遺伝子型に基づいたフコキサンチンによるヘモグロビンA1cの低下効果2018
- Author(s)
  三上奈々・細川雅史・宮下和夫・相馬仁・小海康夫
- Organizer
  第8回学際的脂質創生研究部会講演会
- Data Source
  KAKENHI-PROJECT-16K21251
[Presentation] Fucoxanthin Improves HbA1c in G/G Allele Carriers of UCP1 Polymorphism in Japanese: Rumoi Fucoxanthin Study2017
- Author(s)
  Nana Mikami, Masashi Hosokawa, Kazuo Miyashita, Hitoshi Sohma, Yoichi M. Ito, Yasuo Kokai
- Organizer
  2017 AOCS Annual Meeting and Industry Showcases
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K21251
[Presentation] UCP1遺伝子多型に基づいたフコキサンチンによるヘモグロビンA1c低下効果2017
- Author(s)
  三上奈々・細川雅史・宮下和夫・相馬仁・小海康夫
- Organizer
  第71回日本栄養・食糧学会大会
- Data Source
  KAKENHI-PROJECT-16K21251
[Presentation] 日本人を対象としたフコキサンチンのヘモグロビンA1c低下効果2016
- Author(s)
  三上奈々・細川雅史・宮下和夫・相馬仁・小海康夫
- Organizer
  第70回日本栄養・食糧学会大会
- Place of Presentation
  武庫川女子大（兵庫県西宮市）
- Year and Date
  2016-05-13
- Data Source
  KAKENHI-PROJECT-16K21251
[Presentation] インスリンパワー健診に基づく2型糖尿病リスク予測の検討2012
- Author(s)
  佐田文宏,小海康夫,今泉晃広,松木圭代,多田光宏,笹川裕
- Organizer
  第82回日本衛生学会学術総会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23659363
[Presentation] インスリンパワー健診に基づく２型糖尿病リスク予測の検討．2012
- Author(s)
  佐田文宏，小海康夫，今泉晃広，松木圭代，多田光宏，笹川　裕．
- Organizer
  第82回日本衛生学会学術総会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23659363
[Presentation] Risk prediction for type 2 diabetes by insulin power health examination.2012
- Author(s)
  Sata F, Kokai Y, Imaizumi A, Matsuki Kayo, Tada Mitsuhiro, Sasagawa Y.
- Organizer
  DOHaD 2012 Satellite Meeting: New Developments in Developmental Epidemiology
- Place of Presentation
  Rotterdam
- Data Source
  KAKENHI-PROJECT-23659363
[Presentation] Risk prediction for type 2 diabetes by insulin power health examination2012
- Author(s)
  Sata F, Kokai Y, Imaizumi A, Matsuki Kayo, Tada Mitsuhiro, Sasagawa Y
- Organizer
  DOHaD 2012 Satellite Meeting : New Developments in Developmental Epidemiology
- Place of Presentation
  Rotterdam
- Data Source
  KAKENHI-PROJECT-23659363
[Presentation] インスリンパワー健診に基づく生活習慣病リスク予測の検討―るもいコホートピア・パイロットスタディ―2012
- Author(s)
  佐田文宏,小海康夫,松木圭代,山田康博,大西美穂,小方崇嗣,松浦麻乃,田中裕子,松田美幸,梅田治子,山崎洋子,江藤亜紀子,西條泰明,海野聡,齋藤幹夫,浦崎真,武田浩一,多田光宏,笹川裕
- Organizer
  第22回日本疫学会学術総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23659363
[Presentation] インスリンパワー健診に基づく生活習慣病リスク予測の検討―るもいコホートピア・パイロットスタディ―．2012
- Author(s)
  佐田文宏，小海康夫，松木圭代，山田康博，大西美穂，小方崇嗣，松浦麻乃，田中裕子，松田美幸，梅田治子，山崎洋子，江藤亜紀子，西條泰明，海野　聡，齋藤幹夫，浦崎真，武田浩一，多田光宏，笹川裕．
- Organizer
  第22回日本疫学会学術総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23659363
[Presentation] 生活習慣病の早期予防を目的としたICT 活用指導モデル2011
- Author(s)
  多田光宏,笹川裕,吉田晃敏,上野芳經,齊藤忠範,澁佐隆,白井丙午郎,黒田直秀,日高輝夫,海野聡,小海康夫
- Organizer
  第2回日本プライマリケア連合学会
- Place of Presentation
  札幌
- Year and Date
  2011-07-02
- Data Source
  KAKENHI-PROJECT-23659363
[Presentation] 地域活性化のための多目的オープンフィールド『るもいコホート』における様々な取り組みと成果2011
- Author(s)
  多田光宏,笹川裕,佐田文宏,小海康夫,濱田修平,相馬仁,花田一臣,石子智士,吉田晃敏,斉藤幹夫
- Organizer
  第2回日本プライマリケア連合学会
- Place of Presentation
  札幌
- Year and Date
  2011-07-02
- Data Source
  KAKENHI-PROJECT-23659363
[Presentation] 地域活性化のための多目的オープンフィールド「るもいコホート」における様々な取り組みと成果．2011
- Author(s)
  多田光宏，笹川裕，佐田文宏，小海康夫，濱田修平，相馬仁，花田一臣，石子智士，吉田晃敏，斉藤幹夫．
- Organizer
  第２回日本プライマリケア連合学会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23659363
[Presentation] 生活習慣病の早期予防を目的としたＩＣＴ活用指導モデル．2011
- Author(s)
  多田光宏，笹川裕，吉田晃敏，上野芳経，斉藤忠範，渋佐隆，白井丙午郎，黒田直秀，日高輝夫，海野聡，小海康夫．
- Organizer
  第２回日本プライマリケア連合学会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23659363
[Presentation] 「留萌式メタボ・アンケート」を用いた生活習慣病早期スクリーニング法の開発と検証2011
- Author(s)
  白井丙午郎,笹川裕,濱田修平,岸野宏貴,上野芳經,齊藤忠範,萩原晋二,茎津武大,体重(p<0.001)、腹囲(p<0.001)、BMI 宮島治也,野田さや香,保木寿文,高橋文彦,大藏美奈子,會田誠,多田光宏,小海康夫,佐田文宏,西條泰明,加茂憲一,澁佐隆,海野聡
- Organizer
  第54回日本糖尿病学会年次学術集会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23659363
[Presentation] 住民健診における生活習慣病高リスク者早期発見法の考案．2011
- Author(s)
  笹川裕，多田光宏，小海康夫，佐田文宏，海野聡，白井丙午郎，上野芳經，齊藤忠範，澁佐隆，萩原晋二，濱田修平，岸野宏貴，茎津武大，宮島治也，野田さや香，保木寿文，高橋文彦，大藏美奈子，會田誠．
- Organizer
  第54回日本糖尿病学会年次学術集会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23659363
[Presentation] 「留萌式メタボ・アンケート」を用いた生活習慣病早期スクリーニング法の開発と検証．2011
- Author(s)
  白井丙午郎，笹川裕，濱田修平，岸野宏貴，上野芳經，齊藤忠範，萩原晋二，茎津武大，宮島治也，野田さや香，保木寿文，高橋文彦，大藏美奈子，會田　誠，多田光宏，小海康夫，佐田文宏，西條泰明他．
- Organizer
  第54回日本糖尿病学会年次学術集会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23659363
[Presentation] Investigation of novel biomarkers for Alzheimer's disease using lipid-coated nanoparticles2011
- Author(s)
  Sohma H, Yamaguchi M, Kimura M, Imai S, Matsumoto K, Takei N, Kokai Y
- Organizer
  2^<nd> World Congress on Biomarkers and Clinical Research
- Place of Presentation
  Baltimore, U. S. A
- Year and Date
  2011-09-03
- Data Source
  KAKENHI-PROJECT-21591489
[Presentation] Investigation of novel biomarkers for Alzheimer's disease2011
- Author(s)
  Sohma H, Ymamguchi M, Kimura M, Imai S, Matsumoto K, Hashimoto E, Saito T, Kokai Y
- Organizer
  10^<th> World Congress of Biological Psychiatry
- Place of Presentation
  Prague, Czech Republic
- Year and Date
  2011-05-31
- Data Source
  KAKENHI-PROJECT-21591489
[Presentation] 住民健診における生活習慣病高リスク者早期発見法の考案2011
- Author(s)
  笹川裕,多田光宏,小海康夫,佐田文宏,海野聡,白井丙午郎,上野芳經,齊藤忠範,澁佐隆,萩原晋二,濱田修平,岸野宏貴,茎津武大,宮島治也,野田さや香,保木寿文,高橋文彦,大藏美奈子,會田誠
- Organizer
  第54回日本糖尿病学会年次学術集会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23659363
[Presentation] Activation of glial cells in the spinal cord of a lumbar radiculopathy model.2009
- Author(s)
  Takahata S, Takebayashi T, Terashima Y, Tanimoto K, Wada T, Sohma H, Kokai Y, Yamashita T
- Organizer
  Orthropaedic Research Society(ORS)
- Place of Presentation
  Las Vegas, USA
- Year and Date
  2009-02-22
- Data Source
  KAKENHI-PROJECT-19390398
[Presentation] 神経根性疼痛モデルにおける脊髄microgliaの活動性の変化2009
- Author(s)
  高畑成雄、谷本勝正、竹林庸雄、山下敏彦、相馬仁、小海康夫
- Organizer
  日本脊椎脊髄病学会
- Place of Presentation
  神戸市
- Year and Date
  2009-04-23
- Data Source
  KAKENHI-PROJECT-19390398
[Presentation] 神経根絞扼モデルラットにおける脊髄の可塑的変化2008
- Author(s)
  高畑成雄、谷本勝正、寺島嘉紀、竹林庸雄、山下敏彦、相馬仁、小海康夫
- Organizer
  北海道整形災害外科学会
- Place of Presentation
  札幌市
- Year and Date
  2008-01-26
- Data Source
  KAKENHI-PROJECT-19390398
[Presentation] (Symposium)2007
- Author(s)
  Kokai, Y
- Organizer
  Neuro2007
- Place of Presentation
  Yokohama, Japan
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591303
[Presentation] Exploration of plasma biomarkers for Alzheimer's disease in coupling with biochemical and cognitive-psychological approach2007
- Author(s)
  小海康夫
- Organizer
  日本神経化学会
- Place of Presentation
  横浜
- Year and Date
  2007-09-12
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591303

1. SOHMA Hitoshi (70226702)

# of Collaborated Projects: 5 results

# of Collaborated Products: 18 results
2. SAWADA Norimasa (30154149)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. MORI Michio (00045288)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
4. TOBIOKA Hirotoshi (90291559)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. SAITO Toshikazu (50128518)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
6. JIMBOW Kowichi (30094238)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. YAMASHITA Toshiharu (50167706)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. YAMASHITA Toshihiko (70244366)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
9. WADA Takuro (00244369)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. TAKEBAYASHI Tsuneo (30347166)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
11. ISHIAI Sumio (80193241)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. TOSE Noritsugu (80192657)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. SATA Fumihiro (90187154)

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results
14. SAIJO Yasuaki (70360906)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
15. IMAI Hirohisa (20316631)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
16. NAKAO Hiroyuki (40336293)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. ETO Akiko (50291125)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
18. ITAKURA Mitsuo (60134227)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. MIYAZAKI Junichi (10200156)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. YOSHIMOTO Katsuhiko (90201863)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. NISHIMURA Chihiro (70150571)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. OYAMADA Masahito (30183255)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. ISHII Seiichi (20001000)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. SAKANE Fumio (10183815)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. HIROSAKI Kuninori (00363705)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. IKEDA NOZOMU (00274944)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. MURAKAMI Shinji (30142756)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. YASUYOSHI Naishiro (80347161)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. HIMI Tetsuo (90181114)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. INAGAKI Masumi (70203198)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. Mikami Nana (80700278)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
32. 千葉英樹 (00295346)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. 斎田俊明 (10010381)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
34. 影下登志郎 (20152605)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
35. 佐々木浩一 (10404641)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
36. 相木比古乃 (10438004)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
37. 姫野國祐 (50112339)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
38. 服部淳夫 (90208538)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
39. 堀司 (20398324)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
40. 水江由佳 (20464480)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
41. 大橋美帆子 (80843482)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
42. KAMOGASHIRA Takashi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
43. IWAHANA Hiroyuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

KOKAI Yasuo 小海 康夫

小海 康夫 コカイ ヤスオ

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Identification and molecular dissection of pathological mechanisms in tissue injury of graft-versus-host diseasePrincipal Investigator

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Identification and molecular dissection of pathological mechanisms in tissue injury of graft-versus-host diseasePrincipal Investigator

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A fundamental study aiming development of molecular diagnosis for neuropathic painPrincipal Investigator

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Fundamental study of patholofgival role of CCL8 in GVHDPrincipal Investigator

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Identification of inner ear specific protein binds to connexin 26Principal Investigator

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KOKAI Yasuo 小海康夫

小海康夫コカイヤスオ