Inoue Hideshi 井上英史

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INOUE Hideshi 井上英史

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Researcher Number	20184765
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2023: 東京薬科大学, 生命科学部, 名誉教授 2021 – 2022: 東京薬科大学, 生命科学部, 教授 2008 – 2013: Tokyo University of Pharmacy and Life Science, 生命科学部, 教授 1995 – 2002: 東京薬科大学, 生命科学部, 助教授 1994: 東京大学, 大学院理学系研究科, 助手 1993 – 1994: 東京大学, 大学院・理学系研究科, 助手 1990 – 1991: 東京大学, 理学部, 助手
Review Section/Research Field	Principal Investigator Basic Section 47050:Environmental and natural pharmaceutical resources-related / Functional biochemistry / 医薬分子機能学 / Chemical biology / Biological pharmacy / Structural biochemistry Except Principal Investigator Structural biochemistry / 物質生物化学 / Chemical biology / Inorganic chemistry
Keywords	Principal Investigator RNAi / C. elegans / 線虫 / グルタチオントランスフェラーゼ / 触媒機構 / グルタチオン / protease / Brugia malayi / ポストゲノム / プロテアーゼ … More / Caenorhabditis elegans / 寿命 / プロシアニジン / チオレドキシン / アスパラギン酸プロテアーゼ / 感覚神経 / 老化 / 神経 / ポリフェノール / 抗老化 / proteolysis / ADAMTS / プロテアソーム / プロテアーゼインビター / プロテオリシス / parasite / post genome / nematode / filaria / 金属プロテアーゼ / システインプロテアーゼ / cDNA / 阻害剤 / 寄生虫 / フィラリア / 感受性 / 薬剤排出トランスポーター / 生理活性物質 / 変異株 / 発生 / 生薬 / Rasシグナル / 生理活性 / Ras / スクリーニング / 生物活性物質 / C.elegans / 変異原性試験 / 発現系 / NMR / チオール / システイン / 分子動力学 / 静電ポテンシャル / 薬物代謝酵素 / 基質特異性 / 部位特異的変異 / X線結晶解析 / タンパク質立体構造 / 蛋白工学 / アスペルギルス・ニガ- / 活性中心 / 非ペプシン型酸性プロテアーゼ … More Except Principal Investigator アスパラギン酸プロテアーゼ / NMR / プロテアーゼ / X線結晶構造解析 / 金属プロテアーゼ / フィラリア / システインプロテアーゼ / Brugia malayi / プロガストリン分解プロテアーゼ / トリプシン / ヘプシン / エンテロペプチダーゼ / Cathepsin E / Proctase A / cDNA / 基質特異性 / 自己触媒的活性化 / カテプシンE / 環境汚染物質 / 部位特異的変異 / heterologous expression / cDNA cloning / deubiquitinating enzyme / metalloprotease / cysteine protease / Aspartic protease / filaria / 線虫 / 抗体染色 / 組織内分布 / マレー糸状虫 / 異宿主発現 / cDNAクローニング / 脱ユビチキン化プロテアーゼ / マレー系状虫 / Proteinase / Membrane-bound proteinase / Colopsin / Hepsin / CAAX-motif-specific proteinase / Progastrin-cleaving proteinase / Brain-gut proteinase / α-キモトリプシン / CAAX-モチーフ特異的プロテアーゼ / セリンプロテアーゼ / 膜結合性プロテアーゼ / カテプシンE遺伝子 / 膜結合プロテアーゼ / コロプシン / CAAXモチーフ特異的プロテアーゼ / 脳・腸管系プロテアーゼ / Bovine filaria / Human filaria / Base sequence analysis / Cloning / Cryteine proteinase / Aspartic proteinase / cDNA Library / Filarial proteinase / PCR / 塩基配列解析 / カテプシンD / カテプシンS / ガストリックシン / カテプシンロ / フィラリアプロテアーゼ / ウシ・フィラリア / ヒト・フィラリア / 塩基配列決定 / クローニング / システイン・プロテアーゼ / cDNAライブラリー / フィラリア・プロテアーゼ / trypsin / _2-macroglobulin / pepsinogen / hepsin / enteropeptidase / gastric trypsin / VIP-degrading endopeptidase / gastrointestinal proteinase / 蛋白分解 / プロセシング / 細胞内トリプシン / β-アミロイドペプチド / αキモトリプシン / プロリルエンドペプチダーゼ / α_2マクログロブリン / α_2マクログラブリン / ペプシノーゲン / 胃トリプシン / VIP分解エンドペプチダーゼ / 胃・腸管系プロテアーゼ / X-ray crystallography / active site asparticacid residue / autocatalytic activation / site-directed mutagenesis / carboxyl proteinase / Proctase B / 部位指定突然変異導入法 / 部位指定突然異導入法 / 前駆体活性化 / 活性中心カルボキシル基 / カルボキシルプロテアーゼ / 活性中心アスパラギン酸残基 / 部位特異的変異導入法 / カルボキシルプロテアーゼ / プロクターゼB / プロクターゼA / Autocatalytic activation / Protease precursor / Physarum acid protease / Copia protease / Acid protease / Carboxyl protease / ペプシノ-ゲン / 粘菌プロテア-ゼ / トランスポゾンプロテア-ゼ / 遺伝子 / X線結晶解析 / 水溶性カルボジイミド / プロテア-ゼ前駆体 / 粘菌酸性プロテア-ゼ / コピアプロテア-ゼ / プロクタ-ゼA / 酸性プロテア-ゼ / カルボキシルプロテア-ゼ / activety-based probe / プロテオミクス解析 / アクティビティーベースドプローブ / ユビキチン様ドメイン / プローブ / 酸化ストレス / 活性制御 / activity-based probe / 脱ユビキチン化酵素 / ユビキチン / 一酸化窒素 / 酸素化酵素 / 光感受性色素 / インスリン / 活性酸素 / シグナル伝達 / 分子設計 / 精密金属錯体 / 活性部位残基 / 蛋白工学 / グルタチオンS-トランスフェラーゼ / 脱ハロゲン化 / ハロゲン化炭化水素 / 触媒残基 / キメラ酵素 / 構造・機能相関 / ハロゲン化炭化水素代謝酵素 / グルタチオンS-転移酵素 Less

Mechanism of lifespan extension by procyanidins in C. elegansPrincipal Investigator
- Principal Investigator
  
  Inoue Hideshi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47050:Environmental and natural pharmaceutical resources-related
- Research Institution
  Tokyo University of Pharmacy and Life Science
Biochemical and physiological studies on deubiquitinating enzymes based on an analysis of the enzymatic activity dynamics
- Principal Investigator
  
  HATTORI Akira
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Chemical biology
- Research Institution
  Kyoto University
High efficient screening for bioactive compounds using C. elegans mutant strainsPrincipal Investigator
- Principal Investigator
  
  INOUE Hideshi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical biology
- Research Institution
  Tokyo University of Pharmacy and Life Science
Post-genome analysis on proteolytic systems of multicellular organismPrincipal Investigator
- Principal Investigator
  
  INOUE Hideshi
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  Tokyo University of Pharmacy and Life Science Grant-in Aid for Scientific Research ( C ) (2)
チオレドキシン類似インタエレメント酵素群の構造機能相関と分子進化Principal Investigator
- Principal Investigator
  
  井上英史
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Tokyo University of Pharmacy and Life Science
Post-genome study on filarial proteases for development of inhibitors.Principal Investigator
- Principal Investigator
  
  HIDESHI Inoue
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  医薬分子機能学
- Research Institution
  Tokyo University of Pharmacy and Life Science
Molecular Biological Studies on the Proteases and .Their Inhibifors of Filarial Parasites
- Principal Investigator
  
  TAKAHASHI Kenji
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  Tokyo University of Pharmacy and Life Science
チオレドキシン類似インタエレメント酵素群の構造機能相関と分子進化Principal Investigator
- Principal Investigator
  
  井上英史
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Tokyo University of Pharmacy and Life Science
チオレドキシン類似インタエレメント酵素群の構造機能相関と分子進化Principal Investigator
- Principal Investigator
  
  井上英史
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo University of Pharmacy and Life Science
精密金属錯体の分子設計と生体機能
- Principal Investigator
  
  長野哲雄
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Inorganic chemistry
- Research Institution
  The University of Tokyo
Structural, Functional and Physiological Characterization of Novel Brain-Gut Proteinases
- Principal Investigator
  
  TAKAHASHI Kenji
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  Tokyo University of Pharmacy and Life Science
環境汚染物質の除去を目的としたハロゲン化炭素水素代謝酵素の蛋白工学的研究
- Principal Investigator
  
  高橋健治
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo University of Pharmacy and Life Science
立体構造と蛋白工学的解析に基づくグルタチオン・トランスフェラーゼの機能発現機構Principal Investigator
- Principal Investigator
  
  井上英史
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Tokyo University of Pharmacy and Life Science
Studies on Filarial Proteinases and Their Inhibitors for Development of Filarial Drugs
- Principal Investigator
  
  TAKAHASHI Kenji
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  Structural biochemistry
- Research Institution
  Tokyo University of Pharmacy and Life Science
環境汚染物質の除去を目的としたハロゲン化炭化水素代謝酵素の蛋白工学的研究
- Principal Investigator
  
  TAKAHASHI Kenji
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo University of Pharmacy and Life Science
Systematic search for novel proteinases in gastrointestinal tract and studies on their physiological roles and structure/function
- Principal Investigator
  
  TAKAHASHI Kenji
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  Tokyo University of Pharmacy and Life Science
非ペプシン型カルボキシルプロテアーゼ活性中心の検索と構造機能相関Principal Investigator
- Principal Investigator
  
  井上英史
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Structural biochemistry
- Research Institution
  The University of Tokyo
Studies on Carboxyl Proteinases : Comparative Analysis of Functional Structures and Catalytic Mechanisms of Proctases A and B
- Principal Investigator
  
  TAKAHASHI Kenji
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  The University of Tokyo
Studies on the molecular properties and the structure-function relationships of carboxyl proteases of novel type
- Principal Investigator
  
  TAKAHASHI Kenji
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  物質生物化学
- Research Institution
  The University of Tokyo

All 2024 2023 2022 2021 2011 2010

All Journal Article Presentation Book

[Book] 基礎講義天然物医薬品化学2022
- Author(s)
  井上　英史、尹　永淑
- Total Pages
  200
- Publisher
  東京化学同人
- ISBN
  9784807920013
- Data Source
  KAKENHI-PROJECT-21K06618
[Journal Article] Cacao Procyanidins-Induced Lifespan Extension in <i>Caenorhabditis elegans</i> in a Nervous System and CaMKII-Dependent Manner2024
- Author(s)
  Ohmine Keiya、Morinaga Yuki、Kobayashi Sarina、Matsubara Aika、Sadanaga Kaito、Tohtani Shuhei、Saeki Hideaki、Horiuchi Hiroto、Fujikawa Yuta、Sumi Koichiro、Natsume Midori、Inoue Hideshi
- Journal Title
  
  The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences
  
  Volume: 79 Issue: 4
- DOI
  10.1093/gerona/glae050
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06618
[Journal Article] Retusone A, a Guaiane-Type Sesquiterpene Dimer from Wikstroemia retusa and Its Inhibitory Effects on Histone Acetyltransferase HBO1 Expression2022
- Author(s)
  Yun Young Sook、Nakano Tomomi、Fukaya Haruhiko、Hitotsuyanagi Yukio、Nakamura Miho、Umetsu Megumi、Matsushita Nobuko、Miyake Katsunori、Fuchino Hiroyuki、Kawahara Nobuo、Moriya Fuki、Ito Akihiro、Takahashi Yuji、Inoue Hideshi
- Journal Title
  
  Molecules
  
  Volume: 27 Issue: 9 Pages: 2909-2909
- DOI
  10.3390/molecules27092909
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06618, KAKENHI-PROJECT-19H05640
[Journal Article] Ovafolinin A-E, five new ligands from Lyonia ovalifolia2010
- Author(s)
  Kashima K., Sano K., Yun Y.S., Ina H., Kunugi A., Inoue H.
- Journal Title
  
  Chem.Pharm.Bull. 57(2)
  
  Pages: 191-194
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20611017
[Presentation] カカオ・プロシアニジンによる C. elegans の寿命延長における神経系の関与2023
- Author(s)
  大峰京也、堀内寛人、盛永侑希、小林咲里奈、定永魁斗、遠谷修平、佐伯英昭、角公一郎、夏目みどり、井上英史
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-21K06618
[Presentation] プロシアニジンによる線虫 C. elegans の寿命延長機構2023
- Author(s)
  大峰京也, 松原愛華, 盛永侑希, 角公一郎, 夏目みどり, 井上英史
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21K06618
[Presentation] カカオ・プロシアニジンは感覚神経を介して C. elegans の寿命を延長する2021
- Author(s)
  盛永侑希, 小林咲里奈, 定永魁人, 遠谷修平, 佐伯英昭, 雨笠航介, 角公一郎, 夏目みどり, 井上英史
- Organizer
  第94回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21K06618
[Presentation] カカオ・プロシアニジンは感覚神経を介して C. elegans の寿命を延長する2021
- Author(s)
  盛永侑希, 小林咲里奈, 定永魁人, 遠谷修平, 佐伯英昭, 雨笠航介, 角公一郎, 夏目みどり, 井上英史
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K06618
[Presentation] カカオ抽出物は線虫C.elegansのストレス抵抗性を増し寿命を延ばす2011
- Author(s)
  神部明日香,雨笠航介,夏目みどり,角公一郎,井上英史
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-20611017
[Presentation] 糖新生に関与するcAMP/CREB依存的転写を阻害する天然化合物の探索2010
- Author(s)
  野田幸恵,尹永淑,高橋滋,高橋勇二,井上英史
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-20611017
[Presentation] 線虫C.elegansを用いた高感受性生理活性物質スクリーニングの検討2010
- Author(s)
  神部明日香,大内真理奈,豊田美里,井上英史
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-20611017
[Presentation] カカオ抽出物は線虫C.elegansのストレス抵抗性を増強する2010
- Author(s)
  神部明日香,夏目みどり,角公一郎,井上英史
- Organizer
  第54回日本薬学会関東支部大会
- Place of Presentation
  八王子
- Data Source
  KAKENHI-PROJECT-20611017
[Presentation] カカオ抽出物の線虫C.elegansに対する老化抑制効果2010
- Author(s)
  神部明日香,夏目みどり,角公一郎,井上英史
- Organizer
  第15回日本フードファクター学会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-20611017

1. TAKAHASHI Kenji (70011533)

# of Collaborated Projects: 13 results

# of Collaborated Products: 0 results
2. KOJIMA Masaki (90277252)

# of Collaborated Projects: 9 results

# of Collaborated Products: 0 results
3. TANOKURA Masaru (60136786)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. HATTORI Akira (50300893)

# of Collaborated Projects: 1 results

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5. OISHI Shinya (80381739)

# of Collaborated Projects: 1 results

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6. FUJIWARA Hiroshi (30252456)

# of Collaborated Projects: 1 results

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7. MARUYAMA Masato (00399445)

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8. NISHIMURA Shinichi (30415260)

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9. TAKAHASHI Takayuki (80197152)

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10. MURAMATSU Tomonari (70212256)

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11. NISHII Wataru (30287461)

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12. YAMAGATA Hideo (20023468)

# of Collaborated Projects: 1 results

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13. 長野哲雄 (20111552)

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14. 中村聡 (50227899)

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15. 小澤俊彦 (40160858)

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16. 大塚雅巳 (40126008)

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17. 大倉一郎 (90089821)

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18. 丹治雅夫 (50212048)

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19. SENARCTH Dis

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20. R.WEERAPPULI ウィーラプリアール

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21. ATHAUDA Sena

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22. ATHOUDA Senarath B.P.

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23. WINALASIRI Weerappuli R.

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24. DISSONAYAKE Senarath

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25. SENARATH Dis

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26. WEELAPPULI R

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27. SENARATH B.P

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28. DISSANAYAKE セナラッツ

# of Collaborated Projects: 1 results

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29. WIMALASIRI W

# of Collaborated Projects: 1 results

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30. DISSANAYAKE セナラッツ.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Inoue Hideshi 井上 英史

INOUE Hideshi 井上 英史

Research Projects

Research Products

Co-Researchers

Mechanism of lifespan extension by procyanidins in C. elegansPrincipal Investigator

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High efficient screening for bioactive compounds using C. elegans mutant strainsPrincipal Investigator

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Post-genome analysis on proteolytic systems of multicellular organismPrincipal Investigator

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チオレドキシン類似インタエレメント酵素群の構造機能相関と分子進化Principal Investigator

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Post-genome study on filarial proteases for development of inhibitors.Principal Investigator

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チオレドキシン類似インタエレメント酵素群の構造機能相関と分子進化Principal Investigator

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チオレドキシン類似インタエレメント酵素群の構造機能相関と分子進化Principal Investigator

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立体構造と蛋白工学的解析に基づくグルタチオン・トランスフェラーゼの機能発現機構Principal Investigator

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Principal Investigator

Project Period (FY)

Research Category

Research Field

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Principal Investigator

Inoue Hideshi 井上英史

INOUE Hideshi 井上英史

[Presentation] プロシアニジンによる線虫 C. elegans の寿命延長機構2023