HIRAKAWA Toshio 平川俊夫

Researcher Number	20218770
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2005: 九州大学, 病院, 講師 2003 – 2005: 九州大学, 大学病院, 講師 2002: Kyushu University Hospital, Lecturer, 医学部附属病院, 講師 2000 – 2001: 九州大学, 医学部・附属病院, 講師 1999: Kyushu Univ., Faculty of Medicine, Senior Lecturer, 医学部, 講師 1998: 九州大学, 医学部, 助手 1992 – 1996: 九州大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Obstetrics and gynecology / Obstetrics and gynecology Except Principal Investigator Obstetrics and gynecology / Obstetrics and gynecology
Keywords	Principal Investigator MRP3 / MRP1 / MRP2 / cMOAT1 / YB-1 / 薬剤耐性 / 卵巣癌 / β-tubulin / cDNA microarray / ovarian cancer … More / paclitaxel resistance / In vivo樹立薬剤耐性細胞株 / ヒト卵巣癌 / マイクロアレイ / パクリタキセル / β-チュブリン / cDNAマイクロアレイ法 / パクリタキセル耐性 / Drug resistance / Ovarian cancer / MRP-3 / MRP-1 / P糖蛋白 / MRP-2 … More Except Principal Investigator 卵巣癌 / calponin / カルポニン / ovarian cancer / fibroblast / laminin / fibronectin / gene therapy / 遺伝子治療 / p53 / Ovarian Cancer / Endometrial Cancer / CD151 / CD9 / VEGF / Fas / Edg / Rcasl / TNF-α / Fas Ligand / アポトーシス / 線維芽細胞 / uterine cancer / invasion / 接着因子 / 子宮癌 / 浸潤 / 細胞接着因子 / NECC1 / 胎盤循環 / ヒト胎児 / peritoneal dissemination / 腹膜播種 / micrometastasis / sentinel lymph node / early cervical cancer / 微小転移 / センチネルリンパ節 / 早期子宮頸癌 / peritonitis carcinomatosa / actin / 癌性腹膜炎 / アクチン / HDAC inhibitor / p21 / MDM2 / Erα / senescence / Cancer / Molecular targeted Therapy / CDK結合領域 / mdm2 / 活性型Ras / ERα / 細胞老化誘導遺伝子 / lq42 / ROS / p21CDKインヒビター / 分子標的治療 / エストロゲン受容体α / 絨毛細胞分化 / proline hydroxylase / 細胞老化 / 癌分子標的療法 / 癌細胞老化 / MDM2蛋白 / 巨細胞 / トロホブラスト幹細胞 / ノックアウトマウス胎盤 / NECC1遺伝子 / Signal Transduction / Cadherin / Integrin / シグナル伝達機構 / カドヘリン / インテグリン / Apoptosis / Choriocarcinoma / Rcas1 / 絨毛癌 / trophoblast / prognostic factor / lymphocyte / apoptosis / tumor associated antigen / NK細胞 / 腫瘍分化度 / 子宮体部腫瘍 / 絨毛細胞 / 予後因子 / リンパ球 / 腫瘍関連抗原 / differential display method / three-dimensional cell culture / multicellular spheroid / alkylating agent-resistance / アルデヒド・デヒドロゲナーゼ / ディファレンシヤル・ディスプレイ法 / 3次元培養 / ディファレンシャル・ディスプレイ法 / 三次元培養 / 細胞集塊 / アルキル化剤耐性 / Cancer invasion / Cell-cell interaction / PDGF / Ovarian cancer / 癌細胞の浸潤 / 肝細胞増殖因子 / 細胞骨格蛋白 / 間質細胞 / 平滑筋型αアクチン / 癌の浸潤 / 細胞間相互作用 / 血小板由来増殖因子 / cell adhesion molecules / matrix metalloprotease / Ki-67 / E-カドヘリン / IV型コラゲナーゼ / 免疫組織化学 / 微小浸潤癌 / 蛋白分解酵素 / 子宮頚癌 / 子宮体癌 / ファイブロネクチン / 細胞外基質分解酵素 / ラミニン / ファイブロネクケン / マトリックスメタロプロテアーゼ / migration / Cell adhesion molecule / 遊走 / Endothelial cell / Histopathology / Ultrasound velocimetry / Cell biology / Feto-placental circulation / Intrauterine growth retardation / Human Fetus / 成長因子 / 活性酸素 / 好中球 / 胎児胎盤循環 / 超音波音響学 / 細胞増殖能 / 血管内皮細胞 / 病理形態学 / 超音波ドプラ法 / 細胞生物学 / 胎児胎盤循環動態 / 子宮内発育遅延 / American women / Ciliated-cell metaplasia / Endometrial hyperplasia / Geographic variation / Endometrial metaplasia / Endomerial carcinoma / 年令 / 分化度 / 筋層浸潤 / 脈管侵襲 / 病理発生 / 子宮内膜増殖症 / 子宮内膜上皮化生 / 子宮内膜癌 / ドミナント・ネガティブSRF / SRF / トロホブラスト分化 / 海綿層 / 巨細胞層 / ノックアウト / 免疫組織化学的診断 / 細胞形態学的診断 / 婦人科悪性腫瘍 / 腺癌細胞 / 反応性中皮細胞 / 腹腔細胞診 / 胎盤病理 / Discordancy / 胎児発育 / 胎児循環動態 / 双胎 Less

Research for molecular mechanism and clinical application of calponin-gene therapy against Peritoneal dissemination of ovarian cancer
- Principal Investigator
  
  KOBAYASHI Hiroaki
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  KYUSHU UNIVERCITY
絨毛トロホブラストにおけるNECC1シグナル伝達系とその機能の解明
- Principal Investigator
  
  WAKE Norio
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Kyushu University
Study of sentinel node identification and detection of micrometastasis in early cervical cancer
- Principal Investigator
  
  AMADA Satoshi
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  KYUSHU UNIVERSITY
Identification of a candidate gene associated with paclitaxel-resistance and application to a gene therapy in ovarian cancer.Principal Investigator
- Principal Investigator
  
  OGAWA Shinji, 平川俊夫
- Project Period (FY)
  2003 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  KYUSHU UNIVERCITY
A basic trial of gene therapy against peritoneal dissemination of ovarian cancer by calponin h1 gene transfer
- Principal Investigator
  
  KOBAYASHI Hiroaki
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  KYUSHU UNIVERSITY
Molecular targeted therapy by inducing cancer cell senesence
- Principal Investigator
  
  WAKE Norio
- Project Period (FY)
  2002 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  KYUSHU UNIVERCITY
The molecular mechanism and morphological change of oncogenesis of choriocarcinoma
- Principal Investigator
  
  FUJITA Takuji
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Kyushu University
Biological Roles of Integrin Signal Transduction at Cell-Cell Contact in the Invasion and Metastasis of Endometrial Cancer
- Principal Investigator
  
  MIYAMOTO Shingo
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Kyushu University
Cytopathologic study of intrinsic and acquired drug resistance of human ovarian cancer -the role of YB-1 and cMOAT/MRP2 gene-Principal Investigator
- Principal Investigator
  
  HIRAKAWA Toshio
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Kyushu University
ANALYSIS OF GENES RELATED TO ALKYLATING AGENT-RESISTANCE IN IN VIVO-ESTABLISHED DRUG-RESISTANT CELL LINE EXPRESSED ONLY WHEN GROWN AS MULTICELLULAR SPHEROIDS IN VITRO
- Principal Investigator
  
  KOBAYASHI Hiroaki
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Kyushu University
The functional analysis and clinical significance of apotosis inducing factor, RCAS1
- Principal Investigator
  
  SONODA Kenzo
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  KYUSHU UNIVERSITY
Study for tumor cell-stromal cell interaction related with Platelet-derived growth factor produced by ovarian cancer
- Principal Investigator
  
  KOBAYASHI Hiroaki
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Kyushu University
婦人科悪性腫瘍の腹腔細胞診における反応性中皮細胞と腺癌細胞の鑑別に関する研究
- Principal Investigator
  
  井町正士
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Kyushu University
Interaction if Cell Adhesion Molecules and Tumor Cells on the Production of Matrix Metalloprotease in Gynecological CancersPrincipal Investigator
- Principal Investigator
  
  SAITO Toshiaki, 平川俊夫
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  KYUSHU UNIVERSITY
循環動態からみた多胎児の発育、成熟とその変調に関する病態生理学、細胞生物学的研究
- Principal Investigator
  
  SATOH Shoji
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Kyushu University
CELL ADHESION MOLECULES AND INVASION OF UTERINE CANCER
- Principal Investigator
  
  SAITO Toshiaki
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Kyushu University
The regulation of the fetal growth-Assesment of feto-placental circulation and fetal growth promoting activity in the human fetus-
- Principal Investigator
  
  MAEDA Hirotaka
- Project Period (FY)
  1992 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  KYUSHU UNIVERSITY
Endometrial Metaplasia associated with endometrial carcinoma
- Principal Investigator
  
  KAKU Tsunehisa
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Kyusyu University

All 2006 2005

All Journal Article

[Journal Article] Adenovirus-Mediated Calponin h1 Gene Therapy Directed Against Peritoneal Dissemination of Ovarian Cancer : Bifunctional Therapeutic Effects on Peritoneal Cell Layer and Cancer Cells2006
- Author(s)
  Ogura T, Kobayashi H, Ueoka Y, Okugawa K, Kato K, Hirakawa T, Hashimoto S, Taniguchi S, Hashimoto S, Wake N, Nakano H
- Journal Title
  
  Clin Cancer Res 12(17)
  
  Pages: 5216-5223
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14104014
[Journal Article] Adenovirus-Mediated Calponin h1 Gene Therapy Directed against Peritoneal Dissemination of Ovarian Cancer : Bifunctional Therapeutic Effects on Peritoneal Cell Layer and Cancer Cells2006
- Author(s)
  Ogura T, Kobayashi H, Ueoka Y, Okugawa K, Kato K, Hirakawa T, Hashimoto S, Taniguchi S, Hashimoto S, Wake N, Nakano H
- Journal Title
  
  Clin Cancer Res 12(17)
  
  Pages: 5216-5223
- Data Source
  KAKENHI-PROJECT-14104014
[Journal Article] Adenovirus-Mediated Calponin h1 Gene Therapy Directed Against Peritoneal Dissemination of Ovarian Cancer : Bifunctional Therapeutic Effects on Peritoneal Cell Layerand Cancer Cells2006
- Author(s)
  Ogura T, Kobayashi H, Ueoka Y, Okugawa K, Kato K, Hirakawa T, Hashimoto S, Taniguchi S, Hashimoto S, Wake N, Nakano H
- Journal Title
  
  Clin Cancer Res 12(17)
  
  Pages: 5216-5223
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14104014
[Journal Article] Cytological study of early cervical adenocarcinoma : special reference to the depth of invasion2005
- Author(s)
  Kaku T, Kawano Y, Hirakawa T, Koga Y, Kobayashi H, Amada S, et al.
- Journal Title
  
  Cytopathology 16(6)
  
  Pages: 290-294
- Data Source
  KAKENHI-PROJECT-16591668
[Journal Article] Frozen section diagnosis in Gynecology2005
- Author(s)
  Hirakawa T, Ogawa S, Etou T, Amada S, Kaku T
- Journal Title
  
  Japanese Journal of Gynecological Oncology 23(4)
  
  Pages: 530-536
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591668
[Journal Article] 婦人科における術中迅速組織診断法の意義2005
- Author(s)
  平川俊夫, 小川伸二, 衛藤貴子, 尼田覚, 加来恒壽
- Journal Title
  
  日本婦人科腫瘍学会雑誌 23巻・4号
  
  Pages: 530-536
- NAID
  10020561782
- Data Source
  KAKENHI-PROJECT-16591668
[Journal Article] Cytological study of early cervical adenocarcinoma : special reference to the depth of invasion2005
- Author(s)
  Kaku T, Kawano Y, Hirakawa T, Koga Y, Kobayashi H, Amada S et al.
- Journal Title
  
  Cytopathology 16(6)
  
  Pages: 290-294
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591668
[Journal Article] 婦人科における術中迅速組織診断法の意義2005
- Author(s)
  平川俊夫, 小川伸二, 衛藤貴子, 尼田覚, 加来恒壽
- Journal Title
  
  日本婦人科腫?学会雑誌 23巻・4号
  
  Pages: 530-536
- NAID
  10020561782
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591668

1. KOBAYASHI Hiroaki (70260700)

# of Collaborated Projects: 14 results

# of Collaborated Products: 5 results
2. SONODA Kenzo (30294929)

# of Collaborated Projects: 8 results

# of Collaborated Products: 0 results
3. WAKE Norio (50158606)

# of Collaborated Projects: 6 results

# of Collaborated Products: 3 results
4. KAKU Tsunehisa (60185717)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
5. FUKUSHIMA Koutarou (40304779)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
6. KAMURA Toshiharu (30152870)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
7. KATO Kiyoko (10253527)

# of Collaborated Projects: 4 results

# of Collaborated Products: 3 results
8. SAITO Toshiaki (80162212)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
9. UEOKA Yosuke (50372743)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
10. MIYAMOTO Shingo (40209945)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
11. 加藤秀則 (60214392)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
12. SATOH Shoji (00225947)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
13. KOYANAGI Takashi (30136452)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
14. MAEDA Hirotaka (20199631)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
15. SHIGEMATU Toshiyuki (30253438)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
16. FUJITA Takuji (40325460)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
17. OGAWA Shinji (60380391)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
18. AMADA Satoshi (10294919)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
19. TANIGUCHI Shun'ichiro (60117166)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
20. 井上貴史 (70380417)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
21. 浅野間和夫 (30380413)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
22. 松田貴雄 (10304825)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
23. 有馬隆博 (80253532)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
24. TSUKIMORI Kiyomi (90253450)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. OKADOME Masao (30260699)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. SASAKI Masayuki (40240907)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. KOGA Hirohumi (90343318)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
28. 中野仁雄 (40038766)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. 井町正士 (90213230)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. 塚本直樹 (30038830)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. 永田秀昭 (70253408)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. 坂井邦裕 (70264033)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. 矢幡秀昭 (30404065)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
34. 石田清

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

HIRAKAWA Toshio 平川 俊夫

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Identification of a candidate gene associated with paclitaxel-resistance and application to a gene therapy in ovarian cancer.Principal Investigator

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Cytopathologic study of intrinsic and acquired drug resistance of human ovarian cancer -the role of YB-1 and cMOAT/MRP2 gene-Principal Investigator

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Interaction if Cell Adhesion Molecules and Tumor Cells on the Production of Matrix Metalloprotease in Gynecological CancersPrincipal Investigator

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HIRAKAWA Toshio 平川俊夫