OMATA Yoshiaki 小俣義明

Researcher Number	20268840
Affiliation (based on the past Project Information) *help	2014 – 2016: 横浜薬科大学, 薬学部, 教授 2010: 横浜薬科大学, 薬学部, 教授 2007 – 2008: Yokohama College of Pharmacy, 薬学部, 教授 2006: 久留米大学, 医学部, 助教授 1999 – 2004: 久留米大学, 医学部, 助教授 1998: 久留米大学, 医学部, 講師
Review Section/Research Field	Principal Investigator Functional biochemistry / Bio-related chemistry / Chemistry related to living body Except Principal Investigator Biological Sciences / Drug development chemistry
Keywords	Principal Investigator ハイドロキシメチルビラン合成酵素 / ウロポルフィリノーゲンIII合成酵素 / ハイドロキシメチルビラン / 先天性骨髄性ポルフィリン症 / ウロポルフィリノーゲン / ポルフィリン / hydroxymethylbilane synthase / hydroxymethylbilane / congenital erythropoietic porphyria / uroporphyrinogen III syntase … More / uroporphyrinogen / prophyrin / ポルホビリノーゲン / ヘムタンパク質 / ヒドロキシメチルビラン合成酵素 / ポルフィリン症 / ポルフィリン生合成 / 有機化学 / 生理活性 / 生体分子 / 蛋白質 / 酵素 … More Except Principal Investigator α-ヒドロキシヘム / ヘムオキシゲナーゼ / 結晶構造 / ヘム-ヘムオキシゲナーゼ複合体 / α-ベルドヘム / ベルドヘム / ヘム分解機構 / 抗酸化 / 阻害様式 / 薬学 / 酵素 / 癌 / 酵素阻害 / トポイソメラーゼ / 抗がん薬 / 生物活性物質 / 構造生物学 / 結晶解析 / ビリベルジン Less

Studies on structural biology of the enzymes involved in porphyriaPrincipal Investigator
- Principal Investigator
  
  OMATA Yoshiaki
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bio-related chemistry
- Research Institution
  Yokohama College of Pharmacy
Development of low toxicity topoisomerase inhibitor (anticancer medicine) with treatment and protective efficacy
- Principal Investigator
  
  SUZUKI Keitarou
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Yokohama College of Pharmacy
PHYSIOLOGICAL ROLE OF THE SIDE-CHAIN ASYMMETRY OF PORPHYRINES THAT ARE UTILIZED IN NATUREPrincipal Investigator
- Principal Investigator
  
  OMATA Yoshiaki
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemistry related to living body
- Research Institution
  Yokohama College of Pharmacy
  Kurume University
Investigation of the mechanism of D-ring inversion in porphyrin biosynthesisPrincipal Investigator
- Principal Investigator
  
  OMATA Yoshiaki
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  Kurume University
ヘムオキシゲナーゼの結晶解析によるヘム分解反応及び酸素活性化機構の解明
- Principal Investigator
  
  野口正人
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kurume University
酸素・電子滴定とESR分光によるヘムオキシゲナーゼ反応の再検討と結晶構造の解析
- Principal Investigator
  
  野口正人
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Kurume University
ヘムオキシゲナーゼの結晶解析によるヘム分解反応及び酸素活性化機構の解明
- Principal Investigator
  
  野口正人
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  Kurume University
酸素・電子滴定とESR分光によるヘムオキシゲナーゼ反応の再検討と結晶構造の解析
- Principal Investigator
  
  NOGUCHI Masato
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Kurume University

All 2016 2015 2011 2008 2004 2003 2002 Other

All Journal Article Presentation Book

[Book] 第96回薬剤師国家試験新国家試験形式解答・解説集(梶原康宏編集)(ISBN978-4-905390-33-6)2011
- Author(s)
  鈴木啓太郎共著,野上靖純、梶原正宏、藤井儀夫、小俣義明、稲葉二朗
- Publisher
  横浜薬科大学
- Data Source
  KAKENHI-PROJECT-20590109
[Book] 酵素ハンドブック2008
- Author(s)
  小俣義明、野口正人
- Publisher
  朝倉書店
- Data Source
  KAKENHI-PROJECT-18550159
[Book] 酵素ハンドブック2008
- Author(s)
  小俣義明
- Publisher
  朝倉書店
- Data Source
  KAKENHI-PROJECT-18550159
[Journal Article] Purification and characterization of human uroporphyrinogen III synthase expressed in Escherichia coli.2004
- Author(s)
  Yoshiaki Omata
- Journal Title
  
  Journal of Biochemistry 136
  
  Pages: 211-220
- NAID
  10016201529
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14580658
[Journal Article] Purification and characterization of human uroporphyrinogen III synthase expressed in Escherichia coli.2004
- Author(s)
  Yoshiaki Omata
- Journal Title
  
  Journal of Biochemistry 136・2
  
  Pages: 211-220
- NAID
  10016201529
- Data Source
  KAKENHI-PROJECT-14580658
[Journal Article] Characterization of rat heme oxygenase-3 gene. Implication of processed pseudogenes derived from heme oxygenase-2 gene.2004
- Author(s)
  Shunsuke Hayashi, Yoshiaki Omata, Hiroshi Sakamoto, Yuichiro Higashimoto, Takayuki Hara, Yasuhiro Sagara, Masato Noguchi
- Journal Title
  
  GENE 336-2
  
  Pages: 241-250
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14580658
[Journal Article] Purification and characterization of human uroporphyrinogen III synthase expressed in Escherichia coli.2004
- Author(s)
  Yoshiaki Omata, Hiroshi Sakamoto, Yuichiro Higashimoto, Shunsuke Hayashi, Masato Noguchi
- Journal Title
  
  J.Biochem. 136-2
  
  Pages: 211-220
- NAID
  10016201529
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14580658
[Journal Article] Purification and characterization of a soluble form of rat liver NADPH-cytochrome P-450 reductase highly expressed in Escherichia coli.2003
- Author(s)
  Shunsuke Hayashi, Yoshiaki Omata, Hiroshi Sakamoto, Takayuki Hara, Masato Noguchi
- Journal Title
  
  Protein Fxpr.Purif. 29-1
  
  Pages: 1-7
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14580658
[Journal Article] Crystal structure of rat heme oxygenase-1 in complex with heme bound to azide. Implication for regiospecific hydroxylation of heme at the alpha-meso carbon.2002
- Author(s)
  Masakazu Sugishima, Hiroshi Sakamoto, Yuichiro Higashimoto, Yoshiaki Omata, Shunsuke Hayashi, Masato Noguchi, Keiichi Fukuyama
- Journal Title
  
  J.Biol.Chem. 277-47
  
  Pages: 45086-45090
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14580658
[Journal Article] Crystal structure of rat apo-heme oxygenase-1(HO-1) : Mechanism of heme binding in HO-1 inferred from structural comparison of the apo and heme complex forms.2002
- Author(s)
  Masakazu Sugishima, Hiroshi Sakamoto, Yoshimitau Kakuta, Yoshiaki Omata, Shunsuke Hayashi, Masato Noguchi, Keiichi Fukuyama
- Journal Title
  
  Biochemistry 41-23
  
  Pages: 7293-7300
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14580658
[Journal Article] The reactivity of α-hydroxyhaem and verdohaem bound to haem oxygenase-1 to dioxygen and sodium dithionite.2002
- Author(s)
  Hiroshi Sakamoto, Yoshiaki Omata, Shunsuke Hayashi, Saori Harada, Graham Palmer, Masato Noguchi
- Journal Title
  
  Eur.J.Biochem. 269-21
  
  Pages: 5231-5239
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14580658
[Presentation] ヒドロキシメチルビラン合成酵素-阻害剤複合体の結晶構造解析2016
- Author(s)
  佐藤秀明，杉島正一，塚口舞，増子隆博，小俣義明，和田啓，久枝良雄，山本健，野口正人
- Organizer
  第16回　日本蛋白質科学会年会
- Place of Presentation
  福岡国際会議場（福岡県福岡市）
- Year and Date
  2016-06-07
- Data Source
  KAKENHI-PROJECT-26410186
[Presentation] ヒドロキシメチルビランシンターゼ－阻害剤複合体の結晶構造解析2015
- Author(s)
  佐藤秀明、杉島正一、塚口舞、増子隆博、小俣義明、和田啓、久枝良雄、山本健、野口正人
- Organizer
  日本分子生物学会・日本生化学会　合同大会
- Place of Presentation
  神戸ポートアイランド（兵庫県神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26410186
[Presentation] 基質類似体を結合したヒドロキシメチルビラン合成酵素の結晶構造解析2015
- Author(s)
  佐藤秀明、杉島正一、塚口舞、増子隆博、小俣義明、和田啓、久枝良雄、山本健、野口正人
- Organizer
  バイオ関連化学シンポジウム
- Place of Presentation
  熊本大学黒髪南地区キャンパス（熊本県熊本市）
- Year and Date
  2015-09-10
- Data Source
  KAKENHI-PROJECT-26410186
[Presentation] ヒドロキシメチルビランシンターゼに対する2-ヨードポルホビリノーゲンの阻害効果と複合体の立体構造の解析2015
- Author(s)
  佐藤秀明、塚口舞、杉島正一、増子隆博、小俣義明、和田啓、久枝良雄、山本健、野口正人
- Organizer
  日本生化学会　九州支部例会
- Place of Presentation
  九州大学箱崎キャンパス（福岡県福岡市）
- Year and Date
  2015-05-16
- Data Source
  KAKENHI-PROJECT-26410186
[Presentation] An Inhibitory Effect of a Porphobilinogen Derivative on Hydroxymethylbilane Synthase and the Crystal Structure of the Enzyme-Inhibitor Complex2015
- Author(s)
  Hideaki Sato, Masakazu Sugishima, Mai Tsukaguchi, Takahiro Masuko, Yoshiaki Omata, Kei Wada, Yoshio Hisaeda, Ken Yamamoto, Masato Noguchi
- Organizer
  Metals in Biology in Wako　－生体内金属元素の機能解明－
- Place of Presentation
  理化学研究所和光キャンパス（埼玉県和光市）
- Year and Date
  2015-06-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26410186
[Presentation] Inhibitory Effect of a Novel Porphobilinogen Analog on the Synthesis of a Heme Precursor by Hydroxymethylbilane Synthase2015
- Author(s)
  Hideaki Sato, Masakazu Sugishima, Mai Tsukaguchi, Takahiro Masuko, Yoshiaki Omata, Kei Wada, Yoshio Hisaeda, Masato Noguchi, Ken Yamamoto
- Organizer
  International Conference on Cytochrome P450
- Place of Presentation
  国立オリンピック記念青少年総合センター（東京都渋谷区）
- Year and Date
  2015-06-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26410186
[Presentation] 新規ポルホビリノーゲン誘導体のヒドロキシメチルビランシンターゼに対する阻害剤としての効果
- Author(s)
  佐藤秀明、塚口舞、杉島正一、増子隆博、小俣義明、和田啓、久枝良雄、野口正人、山本健
- Organizer
  日本化学会
- Place of Presentation
  日本大学理工学部船橋キャンパス／薬学部（千葉県船橋市）
- Year and Date
  2015-03-26 – 2015-03-29
- Data Source
  KAKENHI-PROJECT-26410186

1. NOGUCHI Masato (10124611)

# of Collaborated Projects: 6 results

# of Collaborated Products: 7 results
2. SAKAMOTO Hiroshi (70309748)

# of Collaborated Projects: 4 results

# of Collaborated Products: 6 results
3. 高橋研一 (80250736)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
4. HIGASHIMOTO Yuichiro (40352124)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. SATO Hideaki (60271996)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
6. SUGISHIMA Masakazu (30379292)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
7. SUZUKI Keitarou (10154535)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. HOSONO Tetsuji (20450554)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. OOKAWARA Tadashi (60040325)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 緒方英博 (50108635)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 梶原康宏 (50460283)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 川嶋剛 (60460284)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 新谷彰教 (20588157)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

OMATA Yoshiaki 小俣 義明

Research Projects

Research Products

Co-Researchers

Studies on structural biology of the enzymes involved in porphyriaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of low toxicity topoisomerase inhibitor (anticancer medicine) with treatment and protective efficacy

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

PHYSIOLOGICAL ROLE OF THE SIDE-CHAIN ASYMMETRY OF PORPHYRINES THAT ARE UTILIZED IN NATUREPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation of the mechanism of D-ring inversion in porphyrin biosynthesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ヘムオキシゲナーゼの結晶解析によるヘム分解反応及び酸素活性化機構の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

酸素・電子滴定とESR分光によるヘムオキシゲナーゼ反応の再検討と結晶構造の解析

Principal Investigator

Project Period (FY)

Research Category

Research Institution

ヘムオキシゲナーゼの結晶解析によるヘム分解反応及び酸素活性化機構の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

酸素・電子滴定とESR分光によるヘムオキシゲナーゼ反応の再検討と結晶構造の解析

Principal Investigator

Project Period (FY)

Research Category

Research Institution

[Book] 第96回薬剤師国家試験新国家試験形式解答・解説集(梶原康宏編集)(ISBN978-4-905390-33-6)2011

Author(s)

Publisher

Data Source

[Book] 酵素ハンドブック2008

Author(s)

Publisher

Data Source

[Book] 酵素ハンドブック2008

Author(s)

Publisher

Data Source

[Journal Article] Purification and characterization of human uroporphyrinogen III synthase expressed in Escherichia coli.2004

Author(s)

Journal Title

NAID

Description

Data Source

[Journal Article] Purification and characterization of human uroporphyrinogen III synthase expressed in Escherichia coli.2004

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Characterization of rat heme oxygenase-3 gene. Implication of processed pseudogenes derived from heme oxygenase-2 gene.2004

Author(s)

Journal Title

Description

Data Source

[Journal Article] Purification and characterization of human uroporphyrinogen III synthase expressed in Escherichia coli.2004

Author(s)

OMATA Yoshiaki 小俣義明