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Okuno Yasushi  奥野 恭史

ORCIDConnect your ORCID iD *help
… Alternative Names

OKUNO Yasushi  奥野 恭史

奥野 恭史  オクノ ヤスシ

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Researcher Number 20283666
Affiliation (Current) 2025: 京都大学, 医学研究科, 教授
2025: 国立研究開発法人理化学研究所, 計算科学研究センター, 部門長
Affiliation (based on the past Project Information) *help 2016 – 2024: 京都大学, 医学研究科, 教授
2016: 京都大学, 医学(系)研究科(研究院), 教授
2016: 京都大学, 大学院医学研究科, 教授
2014: 京都大学, 教授
2014: 京都大学, 医学研究科, 教授 … More
2014: 京都大学, 大学院医学研究科, 教授
2011: 京都大学, 薬学研究科(研究院), 教授
2009 – 2010: Kyoto University, 薬学研究科, 教授
2007: 京都大学, 薬学研究科, 准教授
2007: Kyoto University, 薬学研究科, 教授
2006: Kyoto University, Pharmaceutical Sciences, Associate Professor, 薬学研究科, 助教授
2005: 京都大学, 薬学研究科, 研究員(COE)
2004: Kyoto University, Institute for Chemical Research, Instructor, 化学研究所, 助手
2004: 京都大学, 薬学研究所, 研究員(COE)(常勤形態)
2004: 京都大学, 薬学研究科, 研究員(COE)(常勤形態)
2003: 京都大学, 薬学研究科, 助手
2001: 京大, 化学研究所
1996 – 2000: 京都大学, 化学研究所, 教務職員 Less
Review Section/Research Field
Principal Investigator
Physical pharmacy / 医薬分子機能学 / Medical genome science / Complex systems / Drug development chemistry / Biological Sciences
Except Principal Investigator
Biological pharmacy / 医薬分子機能学 / Complex systems / Biological Sciences … More / Basic Section 56040:Obstetrics and gynecology-related / Basic Section 58080:Gerontological nursing and community health nursing-related / Basic Section 50020:Tumor diagnostics and therapeutics-related / Kidney internal medicine / System genome science / Gastroenterology / Medical systems / Bioorganic chemistry / Applied health science Less
Keywords
Principal Investigator
ケミカルゲノミクス / ゲノム / バイオインフォマティクス / ケモインフォマティクス / 遺伝子ネットワーク / ネットワーク / 構造活性相関 / 機械学習 / ドラッグデザイン / 分子間相互作用 … More / キナーゼ / GPCR / システムズバイオロジー / 多分子標的創薬 / マイクロアレイ / ネットワーク創薬 / インシリコ創薬 / 機械学習アルゴリズム / Gタンパク質共役型受容体 / サポートベクターマシン / in silicoスクリーニング / パスウェイ / 酵素 / 代謝経路 / メタボローム / バィオインフォマティクス / 共起 / 遺伝子共発現 / 立体構造解析 / タンパク質 / DNA / 亜鉛フィンガー / 分子動力学計算 / Sp1 / NOE / NMR / 速度定数 / 構造変化 / 基質切断活性 / 塩基対形成 / 活性発現制御 / フラビン / リボザイム / RNA … More
Except Principal Investigator
バイオインフォマティクス / DNA認識 / 分子設計 / 機械学習 / 大腸がん / GPR120 / アルゴリズム / データベース / Transcription factor / Zinc finger / 転写因子 / 亜鉛フィンガー / Molecular design / C-1027 / Gタンパク共役型受容体 / GPCR / 分子間相互作用 / 薬物動態 / DNAチップ / 食道がん / ゲノム情報 / microRNA / マイクロRNA / 子宮体癌 / 免疫ゲノミクス / 婦人科がん / 婦人科腫瘍学 / 多様性 / 腫瘍免疫 / 卵巣癌 / 行動変容 / ヘルスリテラシー / 非アルコール性脂肪性肝疾患 / アルコール性肝疾患 / 予兆モデル / スクリーニング / 縦断調査 / NAFLD / ALD / 特定健診項目 / 脂肪肝 / 非侵襲的スクリーニング / 横断調査 / 疫学調査 / クリニカルシークエンス / がんゲノム / actionability / がんクリニカルシークエンス / 遺伝子変異 / アファチニブ / APC / HER2 / VUS / プロテオーム / メタボローム / ポドサイト / NEP25 / アドリアマイシン / 質量解析 / 糸球体硬化 / 遺伝的アルゴリズム / 相互作用予測 / GPCR / 予測 / 相互作用 / ホヤ / カタユウレイボヤ / ペプチド / 内科 / 「Hypermutated type」大腸癌 / “Hypermutated-type” 大腸がん / Hypermutated-type / レセプトデータ / 医療情報システム / 医学 / データベース研究 / レセプトデータ解析 / GPR 40 family (GPR40,41,43) / GLP-1 (glucagon-like peptide 1) / Intracellular calcium / Free fatty acid / Enteroendocrine cell / Orphan G protein-coupled / GLP-1 / リガンド / 遊離脂肪酸受容体 / ノックアウトマウス / ERK / カルシウムシグナル / 抗体 / GPR40 / G蛋白質共役型受容体 / GPR40ファミリー(GPR40,41,43) / GLP-1(グルカゴン様ペプチド-1) / 細胞内カルシウム / 遊離脂肪酸 / 腸管内分泌細胞 / オーファンG蛋白共役型受容体 / Network topology / GRID / Reaction network / Molecular interaction / Algorithm / Ontology / Bioinformatics / Database / マイクロアレイ発現データ / 知識抽出 / ゲノムデータベース / 相関ルール発見手法 / リンク情報 / アミノ酸配列類似度データ / 経路探索 / 相関クラスタ / グラフ比較 / 酵素反応 / 分子生物学データベース / グリッドコンピューティング / タンパク質間相互作用予測 / 文献からの知識抽出 / タンパク質立体構造予測 / 統合データベース / グラフトポロジー / 糖鎖構造データベース / 化合物構造比較 / ネットワークトポロジー / グリッド / 反応ネットワーク / オントロジー / Molecular disign / Metal peptide / Gene regulation / Binding motif / DNA recognition / Gene target / モチーフ / 転写調節 / 金属ペプチド / 遺伝子制御 / 結合モチーフ / 遺伝子ターゲット / Functional conversion / Genomu information / Artificial repressor / Base recognition / DNA binding / 機能変換 / 人工リプレッサー / 塩基認識 / DNA結合 / Esperamicin / Dynemicin / Enediyne / Radical formation / DNA cleavage / Antitumor antibiotic / 作用発現機構 / 抗癌活性 / DNA設計 / 抗生物質 / エスペラミシン / ダイナミシン / エンジイン / ラジカル発生 / DNA切断 / 抗癌抗生物質 / 代謝異常疾患 / 受容体 / エストロゲン / シグナル伝達 / 生活習慣病 / モデル化 / テキストマイニング / 生理学的モデル / 酵素誘導 / 薬剤反応性 / 構造活性相関 / 生体生命情報学 / 生物学 / 生物物理 / 薬物動態学 / 代謝 / 全身循環 / 不整脈 / 心臓 / 生物物理学 / 生理学 / システム生物学 / バイオインフォマティックス / 疾患動物モデル / RNA / バイオインフォマッティックス / トランスクリプトーム / 分化 / がん / 上皮細胞 / miRNA / バイオマーカー / 乳がん / 発現プロファイル / 超高感度DNAチップ / ネットワーク解析 / 包括的トランスクリプトーム解析 / ゲノム医療 / 食道癌 / 臨床検体 / マイクロアレイ / 個別化医療 / マイクロアレイ解析 / 最尤推定法 / 遺伝子ネットワーク / 遺伝子発現解析 / Non-coding RNA Less
  • Research Projects

    (26 results)
  • Research Products

    (157 results)
  • Co-Researchers

    (69 People)
  •  Social implementation trial of ALD/NAFLD predictive model to improve health literacy and promote behavior change

    • Principal Investigator
      本村 純
    • Project Period (FY)
      2022 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 58080:Gerontological nursing and community health nursing-related
    • Research Institution
      Meio University
  •  Novel diagnostic and therapeutic strategies for ovarian cancer by investigation of cancer and host diversity

    • Principal Investigator
      万代 昌紀
    • Project Period (FY)
      2021 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 56040:Obstetrics and gynecology-related
    • Research Institution
      Kyoto University
  •  Research on Biological and Clinical Significance of VUS in Cancer Clinical Sequencing

    • Principal Investigator
      Muto Manabu
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 50020:Tumor diagnostics and therapeutics-related
    • Research Institution
      Kyoto University
  •  NDBレセプトデータの利活用に向けたデータ解析法の開発研究

    • Principal Investigator
      森 由希子
    • Project Period (FY)
      2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Medical systems
    • Research Institution
      Kyoto University
  •  Development of diagnostic biomarkers for "Hypermutated-type" colorectal cancer

    • Principal Investigator
      YAMADA Atsushi
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Kyoto University
  •  Integration of proteomics and metabolomics for drug discovery based on a search for the pathophysiology in glomerulosclerosis

    • Principal Investigator
      YAN KUNIMASA
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Kidney internal medicine
    • Research Institution
      Kyorin University
  •  Identification of Ciona specific peptides' receptors using machine laearning-based predicition

    • Principal Investigator
      Shiraishi Akira
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      System genome science
    • Research Institution
      Suntory Foundation for Life Sciences
  •  New function of fat-soluble compounds for improvement of life style diseases

    • Principal Investigator
      ADACHI Tetsuya
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Applied health science
    • Research Institution
      Minatogawa College
      Kobe University
      Kyoto Prefectural University of Medicine
  •  Integrated analysis of biological interaction of small molecules at the molecular level of living organisms

    • Principal Investigator
      YAMASHITA Fumiyoshi
    • Project Period (FY)
      2011 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Complex systems
    • Research Institution
      Kyoto University
  •  Establishment of Integrative Multi-level Systems Biology and its Applications

    • Principal Investigator
      KURACHI YOSHIHISA
    • Project Period (FY)
      2010 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Complex systems
    • Research Institution
      Osaka University
  •  小分子-生体システム相互作用の分子階層における統合的解析Principal Investigator

    • Principal Investigator
      奥野 恭史
    • Project Period (FY)
      2010 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Complex systems
    • Research Institution
      Kyoto University
  •  ケミカルゲノミクスに基づく創薬インフォマティクスの開拓Principal Investigator

    • Principal Investigator
      奥野 恭史
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Young Scientists (A)
    • Research Field
      Medical genome science
    • Research Institution
      Kyoto University
  •  次世代型創薬「ネットワーク創薬」の創成Principal Investigator

    • Principal Investigator
      奥野 恭史
    • Project Period (FY)
      2009 – 2010
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Physical pharmacy
    • Research Institution
      Kyoto University
  •  New genome medicine and drug discovery based on the comprehensive transcriptome analysis

    • Principal Investigator
      TSUJIMOTO Gozoh
    • Project Period (FY)
      2007 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (S)
    • Research Field
      Biological pharmacy
    • Research Institution
      Kyoto University
  •  微量臨床検体発現プロファイルによるがんの個別化治療

    • Principal Investigator
      辻本 豪三
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Kyoto University
  •  ケミカルゲノミクスのためのパスウェイ解析法の開発Principal Investigator

    • Principal Investigator
      奥野 恭史
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Drug development chemistry
    • Research Institution
      Kyoto University
  •  未知ゲノム配列non-codingRNAの機能解析

    • Principal Investigator
      TSUJIMOTO Gozoh
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Biological pharmacy
    • Research Institution
      Kyoto University
  •  Identification of ligand and function of novel group of free fatty acid receptors by using genome information.

    • Principal Investigator
      TSUJIMOTO Gozoh
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Biological pharmacy
    • Research Institution
      Kyoto University
  •  ゲノム情報と化学情報の融合に向けたケミカルーゲノム統合ネットワークの構築Principal Investigator

    • Principal Investigator
      奥野 恭史
    • Project Period (FY)
      2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Kyoto University
  •  メタボロームの網羅的解析に向けた代謝ネットワーク予測システムの開発Principal Investigator

    • Principal Investigator
      奥野 恭史
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Physical pharmacy
    • Research Institution
      Kyoto University
  •  高次複合体系における蛋白質-蛋白質-DNA相互作用ネットワークの動的構造解析Principal Investigator

    • Principal Investigator
      奥野 恭史
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      医薬分子機能学
    • Research Institution
      Kyoto University
  •  Construction and Retrieval of Highly Integrated Biological Databases

    • Principal Investigator
      GOTO Susumu
    • Project Period (FY)
      2000 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Kyoto University
  •  遺伝子疾患を標的とした新機能アロステリックリボザイムの新創製と機能解析Principal Investigator

    • Principal Investigator
      奥野 恭史
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      医薬分子機能学
    • Research Institution
      Kyoto University
  •  Creation and Function of Novel Gene Regulation Molecules Based on Zinc Finger Motif

    • Principal Investigator
      SUGIURA Yukio
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      医薬分子機能学
    • Research Institution
      KYOTO UNIVERSITY
  •  Functional Conversion and Artificial Repressor of Zinc Finger Proteins

    • Principal Investigator
      SUGIURA Yukio
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      医薬分子機能学
    • Research Institution
      KYOTO UNIVERSITY
  •  Action mechanism and molecular design of biologically active enediyne compounds

    • Principal Investigator
      SUGIURA Yukio
    • Project Period (FY)
      1995 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Bioorganic chemistry
    • Research Institution
      KYOTO UNIVERSITY

All 2023 2022 2020 2018 2012 2011 2010 2009 2008 2007 2006 2005 2004

All Journal Article Presentation Book Patent

  • [Book] Handbook of Systems Toxicology "In Silico Toxicology Prediction Using Toxicogenomics Data"2011

    • Author(s)
      Yasushi Okuno
    • Total Pages
      8
    • Publisher
      Wiley-Blackwell
    • Data Source
      KAKENHI-PLANNED-22136012
  • [Book] Handbook of Systems Toxicology "In Silico Toxicology Prediction Using Toxicogenomics Data"2011

    • Author(s)
      Yasushi Okuno
    • Total Pages
      8
    • Publisher
      Wiley-Blackwell
    • Data Source
      KAKENHI-PROJECT-22681031
  • [Book] Handbook of Systems Toxicology "In Silico Toxicology Prediction Using Toxic ogenomics Data"2011

    • Author(s)
      Yasushi Okuno
    • Total Pages
      8
    • Publisher
      Wiley-Blackwell
    • Data Source
      KAKENHI-PROJECT-21659009
  • [Book] 薬学の展望とロードマップ"創薬を成功に導く情報戦略"2010

    • Author(s)
      奥野恭史
    • Total Pages
      2
    • Publisher
      日本薬学会
    • Data Source
      KAKENHI-PLANNED-22136012
  • [Book] 医薬ジャーナル 増刊号 新薬展望2010"創薬インフォティクス"2010

    • Author(s)
      奥野恭史
    • Total Pages
      6
    • Publisher
      (株)医薬ジャーナル社
    • Data Source
      KAKENHI-PROJECT-22681031
  • [Book] 薬学の展望とロードマップ"創薬を成功に導く情報戦略"2010

    • Author(s)
      奥野恭史
    • Total Pages
      2
    • Publisher
      日本薬学会
    • Data Source
      KAKENHI-PROJECT-22681031
  • [Book] 薬学の展望とロードマップ"創薬を成功に導く情報戦略"2010

    • Author(s)
      奥野恭史
    • Total Pages
      2
    • Publisher
      日本薬学会
    • Data Source
      KAKENHI-PROJECT-21659009
  • [Book] 医薬ジャーナル 増刊号 新薬展望2010"創薬インフォティクス"2010

    • Author(s)
      奥野恭史
    • Total Pages
      6
    • Publisher
      (株)医薬ジャーナル社
    • Data Source
      KAKENHI-PLANNED-22136012
  • [Book] 医薬ジャーナル 増刊号 新薬展望2010"創薬インフォティクス"2010

    • Author(s)
      奥野恭史
    • Total Pages
      6
    • Publisher
      (株)医薬ジャーナル社
    • Data Source
      KAKENHI-PROJECT-21659009
  • [Book] Biogenesis and Function Mechanisms of Micro-RNAs and Their Role as Oncogenes and Tumor Suppressors, In Systems Biology - The Challenge of Complexity -2009

    • Author(s)
      Tsuchiya, S., Terasawa, K., Kunimoto, R., Okuno, Y., Sato, F., Shimizu, K. and Tsujimoto, G.
    • Total Pages
      7
    • Publisher
      Springer Japan
    • Data Source
      KAKENHI-PROJECT-18790088
  • [Book] MicroRNAs and Discovery of New Targets, In Genomics and Pharmacogenomics in Anticancer Drug Development and Clinical Response2008

    • Author(s)
      Tsuchiya, S., Okuno, Y. and Tsujimoto, G.
    • Total Pages
      10
    • Publisher
      Humana Press
    • Data Source
      KAKENHI-PROJECT-18790088
  • [Book] インシリコ創薬科学-ゲノム情報から創薬へ-2008

    • Author(s)
      (共著)奥野恭史, 他
    • Total Pages
      43
    • Publisher
      京都廣川書店
    • Data Source
      KAKENHI-PROJECT-18790088
  • [Book] インシリコ創薬科学-ゲノム情報から創薬へ-第1章 概論-ゲノム情報から創薬へ2008

    • Author(s)
      藤井信孝, 辻本豪三, 奥野恭史/編集
    • Total Pages
      191
    • Publisher
      京都廣川書店
    • Data Source
      KAKENHI-PROJECT-19109001
  • [Book] 生物物理学ハンドブック2007

    • Author(s)
      奥野恭史ほか, (石渡信一, 桂勲, 桐野豊, 美宅成樹 編)
    • Total Pages
      680
    • Publisher
      株式会社朝倉書店
    • Data Source
      KAKENHI-PROJECT-18790088
  • [Book] バイオインフォマティクス事典2006

    • Author(s)
      奥野恭史ほか, (日本バイオインフォマティクス学会 編)
    • Total Pages
      834
    • Publisher
      共立出版株式会社
    • Data Source
      KAKENHI-PROJECT-18790088
  • [Journal Article] Versican provides the provisional matrix for uterine spiral artery dilation and fetal growth2023

    • Author(s)
      Sagae Yusuke、Horie Akihito、Yanai Akihiro、Ohara Tsutomu、Nakakita Baku、Kitawaki Yoshimi、Okunomiya Asuka、Tani Hirohiko、Yamaguchi Ken、Hamanishi Junzo、Lydon John P.、Daikoku Takiko、Watanabe Hideto、Mandai Masaki
    • Journal Title

      Matrix Biology

      Volume: 115 Pages: 16-31

    • DOI

      10.1016/j.matbio.2022.11.004

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K09541, KAKENHI-PROJECT-21H02720, KAKENHI-PROJECT-23K21473, KAKENHI-PROJECT-22H04922
  • [Journal Article] Nivolumab for malignant transformation of ovarian mature cystic teratoma2022

    • Author(s)
      Yoshimura Kayoko、Yamanoi Koji、Kanai Masashi、Okunomiya Asuka、Sagae Yusuke、Sunada Masumi、Taki Mana、Ukita Masayo、Chigusa Yoshitsugu、Horie Akihito、Yamaguchi Ken、Hamanishi Junzo、Minamiguchi Sachiko、Yamamoto Noboru、Muto Manabu、Mandai Masaki
    • Journal Title

      Gynecologic Oncology Reports

      Volume: 44 Pages: 101115-101115

    • DOI

      10.1016/j.gore.2022.101115

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K09541, KAKENHI-PROJECT-23K21473
  • [Journal Article] E487K-induced disorder in functionally relevant dynamics of mitochondrial aldehyde dehydrogenase 22020

    • Author(s)
      Matsumoto S, Araki M, Isaka Y, Ono F, Hirohashi K, Ohashi S, Muto M, Okuno Y
    • Journal Title

      Biophysical Journal

      Volume: 119 Issue: 3 Pages: 628-637

    • DOI

      10.1016/j.bpj.2020.07.002

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K08369, KAKENHI-PROJECT-17K15106, KAKENHI-PROJECT-18H02692
  • [Journal Article] Association between homologous recombination repair gene mutations and response to oxaliplatin in pancreatic cancer2018

    • Author(s)
      Kondo Tomohiro、Kanai Masashi、Kou Tadayuki、Sakuma Tomohiro、Mochizuki Hiroaki、Kamada Mayumi、Nakatsui Masahiko、Uza Norimitsu、Kodama Yuzo、Masui Toshihiko、Takaori Kyoichi、Matsumoto Shigemi、Miyake Hidehiko、Okuno Yasushi、Muto Manabu
    • Journal Title

      Oncotarget

      Volume: 9 Issue: 28 Pages: 19817-19825

    • DOI

      10.18632/oncotarget.24865

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K08413, KAKENHI-PROJECT-18H02692
  • [Journal Article] Chemogenomic approach to comprehensive predictions of ligand-target interactions: a comparative study2012

    • Author(s)
      J.B. Brown, S. Niijima, A. Shiraishi, M. Nakatsui, Y. Okuno
    • Journal Title

      Proceedings of IEEE International Conference on Bioinformatics and Biomedicine (BIBM 2012), Workshop on Pharmaco-informatics for Drug Discovery (PIDD 2012)

      Volume: 1 Pages: 136-142

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-23136102
  • [Journal Article] 医薬品による有害事象の自発報告システム2011

    • Author(s)
      栄田敏之, 角山香織, 奥野恭史
    • Journal Title

      人工知能学会誌

      Volume: 26 Pages: 126-130

    • Data Source
      KAKENHI-PROJECT-21659009
  • [Journal Article] 医薬品による有害事象の自発報告システム2011

    • Author(s)
      栄田敏之, 角山香織, 奥野恭史
    • Journal Title

      人工知能学会誌

      Volume: 26 Pages: 126-130

    • Data Source
      KAKENHI-PROJECT-22681031
  • [Journal Article] Analysis of multiple compound-protein interactions reveals novel bioactive molecules2011

    • Author(s)
      Yabuuchi, H., Okuno, Y., (他8名)
    • Journal Title

      Molecular Systems Biology

      Volume: 7 Pages: 472-472

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22681031
  • [Journal Article] Analysis of multiple compound-protein interactions reveals novel bioactive molecules2011

    • Author(s)
      Yabuuchi, H., Okuno, Y., (他8名)
    • Journal Title

      Molecular Systems Biology

      Volume: 7 Pages: 472-472

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21659009
  • [Journal Article] 医薬品による有害事象の自発報告システム2011

    • Author(s)
      栄田敏之, 角山香織, 奥野恭史
    • Journal Title

      人工知能学会誌

      Volume: 26 Pages: 126-130

    • Data Source
      KAKENHI-PLANNED-22136012
  • [Journal Article] Analysis of multiple compound-protein interactions reveals novel bioactive molecules2011

    • Author(s)
      Yabuuchi, H., Okuno, Y, (他8名)
    • Journal Title

      Molecular Systems Biology

      Volume: 7 Pages: 472-472

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-22136012
  • [Journal Article] Salt-sensitive hypertension in circadian clock-deficient Cry-null mice involves dysregulated adrenal Hsd3b62010

    • Author(s)
      Doi, M., Okuno, Y., (他13名)
    • Journal Title

      Nature Medicine

      Volume: 16 Pages: 67-74

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21659009
  • [Journal Article] Design, synthesis, evaluation and QSAR analysis of N(1)-substituted norcymserine derivatives as selective butyrylcholinesterase inhibitors2010

    • Author(s)
      Takahashi, J., Okuno, Y., (他10名)
    • Journal Title

      Bioorg.Med.Chem.Lett.

      Volume: 20 Pages: 1718-1720

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-22136012
  • [Journal Article] Identification of EP4 as a potential target for the treatment of castration-resistant prostate cancer using a novel xenograft model2010

    • Author(s)
      Terada, N., Okuno, Y., (他15名)
    • Journal Title

      Cancer Res.

      Volume: 70 Pages: 1606-1615

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-22136012
  • [Journal Article] Salt-sensitive hypertension in circadian clock-deficient Cry-null mice involves dysregulated adrenal Hsd3b62010

    • Author(s)
      Doi, M., Okuno, Y., (他13名)
    • Journal Title

      Nature Medicine

      Volume: 16 Pages: 67-74

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22681031
  • [Journal Article] Cross-target view to feature selection : identification of molecular interaction features in ligand-target space2010

    • Author(s)
      Niijima, S., Yabuuchi, H., Okuno, Y.
    • Journal Title

      J.Chem.Inf.Model.

      Volume: 51 Pages: 15-21

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21659009
  • [Journal Article] Design, synthesis, evaluation and QSAR analysis of N(1)-substituted norcymserine derivatives as selective butyrylcholinesterase inhibitors2010

    • Author(s)
      Takahashi, J., Okuno, Y., (他10名)
    • Journal Title

      Bioorg.Med.Chem.Lett.

      Volume: 20 Pages: 1718-1720

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21659009
  • [Journal Article] Identification of EP4 as a potential target for the treatment of castration-resistant prostate cancer using a novel xenograft model2010

    • Author(s)
      Terada, N., Okuno, Y., (他15名)
    • Journal Title

      Cancer Res.

      Volume: 70 Pages: 1606-1615

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21659009
  • [Journal Article] Abnormal Epithelial Cell Polarity and Ectopic Epidermal Growth Factor Receptor (EGFR) Expression Induced in Emx2 KO Embryonic Gonads2010

    • Author(s)
      Kusaka, M., Okuno, Y., (他14名)
    • Journal Title

      Endocrinology

      Volume: 151 Pages: 5893-5904

    • NAID

      120005227384

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21659009
  • [Journal Article] Expression profiling of cumulus cells reveals functional changes during ovulation and central roles of prostaglandin EP2 receptor in cAMP signaling2010

    • Author(s)
      Tamba S, Yodoi R, Morimoto K, Inazumi T, Sukeno M, Segi-Nishida E, Okuno Y, Tsujimoto G, Narumiya S, Sugimoto Y.
    • Journal Title

      Biochimie

      Volume: 92 Pages: 665-675

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19109001
  • [Journal Article] A reverse transcriptase stop assay revealed diverse quadruplex formations in UTRs in mRNA2010

    • Author(s)
      Hagihara, M., Okuno, Y., (他3名)
    • Journal Title

      Bioorg.Med.Chem.Lett.

      Volume: 20 Pages: 2350-2353

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21659009
  • [Journal Article] Design, synthesis, evaluation and QSAR analysis of N(1)-substituted norcymserine derivatives as selective butyrylcholinesterase inhibitors2010

    • Author(s)
      Takahashi, J., Okuno, Y., (他10名)
    • Journal Title

      Bioorg.Med.Chem.Lett.

      Volume: 20 Pages: 1718-1720

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22681031
  • [Journal Article] Abnormal Epithelial Cell Polarity and Ectopic Epidermal Growth Factor Receptor (EGFR) Expression Induced in Emx2 KO Embryonic Gonads2010

    • Author(s)
      Kusaka, M., Okuno, Y., (他14名)
    • Journal Title

      Endocrinology

      Volume: 151 Pages: 5893-5904

    • NAID

      120005227384

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-22136012
  • [Journal Article] A reverse transcriptase stop assay revealed diverse quadruplex formations in UTRs in mRNA2010

    • Author(s)
      Hagihara, M., Okuno, Y., (他3名)
    • Journal Title

      Bioorg.Med.Chem.Lett.

      Volume: 20 Pages: 2350-2353

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22681031
  • [Journal Article] Cross-target view to feature selection : identification of molecular interaction features in ligand-target space2010

    • Author(s)
      Niijima, S., Yabuuchi, H., Okuno, Y.
    • Journal Title

      J.Chem.Inf.Model.

      Volume: 51 Pages: 15-21

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-22136012
  • [Journal Article] Expression profiling of cumulus cells reveals functional changes during ovulation and central roles of prostaglandin EP2 receptor in cAMP signaling2010

    • Author(s)
      Tamba, S., Okuno, Y., (他8名)
    • Journal Title

      Biochimie

      Volume: 92 Pages: 665-675

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22681031
  • [Journal Article] Expression profiling of cumulus cells reveals functional changes during ovulation and central roles of prostaglandin EP2 receptor in cAMP signaling2010

    • Author(s)
      Tamba, S., Okuno, Y., (他8名)
    • Journal Title

      Biochimie

      Volume: 92 Pages: 665-675

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-22136012
  • [Journal Article] A novel chemogenomics analysis of G protein-coupled receptors (GPCRs) and their ligands : a potential strategy for receptor de-orphanization2010

    • Author(s)
      van der Horst, E., Okuno, Y., (他7名)
    • Journal Title

      BMC Bioinformatics

      Volume: 11 Pages: 316-316

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21659009
  • [Journal Article] Identification of EP4 as a potential target for the treatment of castration-resistant prostate cancer using a novel xenograft model2010

    • Author(s)
      Terada, N., Okuno, Y., (他15名)
    • Journal Title

      Cancer Res.

      Volume: 70 Pages: 1606-1615

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22681031
  • [Journal Article] Abnormal Epithelial Cell Polarity and Ectopic Epidermal Growth Factor Receptor (EGFR) Expression Induced in Emx2 KO Embryonic Gonads2010

    • Author(s)
      Kusaka, M., Okuno, Y., (他14名)
    • Journal Title

      Endocrinology

      Volume: 151 Pages: 5893-5904

    • NAID

      120005227384

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22681031
  • [Journal Article] Cross-target view to feature selection : identification of molecular interaction features in ligand-target space2010

    • Author(s)
      Niijima, S., Yabuuchi, H., Okuno, Y.
    • Journal Title

      J.Chem.Inf.Model.

      Volume: 51 Pages: 15-21

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22681031
  • [Journal Article] Salt-sensitive hypertension in circadian clock-deficient Cry-null mice involves dysregulated adrenal Hsd3b6.2010

    • Author(s)
      Doi M, Takahashi Y, Komatsu R, Yamazaki F, Yamada H, Haraguchi S, Emoto N, Okuno Y, Tsujimoto G, Kanematsu A, Ogawa O, Todo T, Tsutsui K, van der Horst GT, Okamura H.
    • Journal Title

      Nature Medicine

      Volume: 16 Pages: 67-74

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19109001
  • [Journal Article] A novel chemogenomics analysis of G protein-coupled receptors (GPCRs) and their ligands : a potential strategy for receptor de-orphanization2010

    • Author(s)
      van der Horst, E., Okuno, Y., (他7名)
    • Journal Title

      BMC Bioinformatics

      Volume: 11 Pages: 316-316

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-22136012
  • [Journal Article] A novel chemogenomics analysis of G protein-coupled receptors (GPCRs) and their ligands : a potential strategy for receptor de-orphanization2010

    • Author(s)
      van der Horst, E., Okuno, Y., (他7名)
    • Journal Title

      BMC Bioinformatics

      Volume: 11 Pages: 316-316

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22681031
  • [Journal Article] Salt-sensitive hypertension in circadian clock-deficient Cry-null mice involves dysregulated adrenal Hsd3b62010

    • Author(s)
      Doi, M., Okuno, Y., (他13名)
    • Journal Title

      Nature Medicine

      Volume: 16 Pages: 67-74

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-22136012
  • [Journal Article] Expression profiling of cumulus cells reveals functional changes during ovulation and central roles of prostaglandin EP2 receptor in cAMP signaling2010

    • Author(s)
      Tamba, S., Okuno, Y., (他8名)
    • Journal Title

      Biochimie

      Volume: 92 Pages: 665-675

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21659009
  • [Journal Article] A reverse transcriptase stop assay revealed diverse quadruplex formations in UTRs in mRNA2010

    • Author(s)
      Hagihara, M., Okuno, Y., (他3名)
    • Journal Title

      Bioorg.Med.Chem.Lett.

      Volume: 20 Pages: 2350-2353

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-22136012
  • [Journal Article] GEM-TREND : a web tool for Gene Expression data Mining Toward Relevant Network Discovery2009

    • Author(s)
      Feng, C., Araki, H., Kunimoto, R., Tamon, A., Makiguchi, H., Niijima, S., Tsujimoto, G., Okuno, Y.
    • Journal Title

      BMC Genomics Vol. 10

      Pages: 411-411

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21659009
  • [Journal Article] Substructure mining of GPCR ligands reveals activity-class specific functional groups in an unbiased manner2009

    • Author(s)
      van der Horst, E., Okuno, Y., Bender, A., Ijzerman, A. P.
    • Journal Title

      J. Chem. Inf. Model. 49

      Pages: 348-360

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18790088
  • [Journal Article] Characterization of gene expression profiles for different types of mast cells pooled from mouse stomach subregions by an RNA amplification method2009

    • Author(s)
      Tsuchiya, S., Tachida, Y., Segi-Nishida, E., Okuno, Y., Tamba, S., Tsujimoto, G., Tanaka, S., Sugimoto, Y.
    • Journal Title

      BMC Genomics 10

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18790088
  • [Journal Article] Global correlation analysis for micro-RNA and mRNA expression profiles in human cell lines2008

    • Author(s)
      Ruike, Y., Ichimura, A., Tsuchiya, S., Shimizu, K., Kunimoto, R., Okuno, Y., Tsujimoto, G.
    • Journal Title

      J. Hum. Genet. 53

      Pages: 515-523

    • NAID

      10021249241

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18790088
  • [Journal Article] Establishment of the culture model system that reflects the process of terminal differentiation of connective tissue-type mast cells2008

    • Author(s)
      Takano, H., Nakazawa, S., Okuno, Y., Shirata, N., Tsuchiya, S., Kainoh, T., Takamatsu, S., Furuta, K., Taketomi, Y., Naito, Y., Takematsu, H., Kozutsumi, Y., Tsujimoto, G., Murakami, M., Kudo, I., Ichikawa, A., Nakayama, K., Sugimoto, Y., Tanaka, S.
    • Journal Title

      FEBS Lett. 582

      Pages: 1444-1450

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18790088
  • [Journal Article] GLIDA : GPCR-ligand database for chemical genomics drug discovery - Database and tools update2008

    • Author(s)
      Okuno, Y., Tamon, A., Yabuuchi, H., Niijima, S., Minowa, Y., Tonomura, K., Kunimto, R., Feng, C.
    • Journal Title

      Nucleic Acids Res. 36

      Pages: 907-912

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18790088
  • [Journal Article] Secreted CXCL1 is a potential mediator and marker of the tumor invasion of bladder cancer2008

    • Author(s)
      Kawanishi, H., Matsui, Y., Ito, M., Watanabe, J., Takahashi, T., Nishizawa, K., Nishiyama, H., Kamoto, T., Mikami, Y., Tanaka, Y., Jung, G., Akiyama, H., Nobumasa, H., Guilford, P., Reeve, A., Okuno, Y., Tsujimoto, G., Nakamura, E., Ogawa, O.
    • Journal Title

      Clin. Cancer Res. 14

      Pages: 2579-2587

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18790088
  • [Journal Article] Global correlation analysis for micro-RNA and mRNA expression profiles in human cell lines.2008

    • Author(s)
      Ruike Y, Ichimura A, Tsuchiya S, Shimizu K, Kunimoto R, Okuno Y, Tsujimoto G.
    • Journal Title

      J Hum Genet 53

      Pages: 515-523

    • NAID

      10021249241

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19109001
  • [Journal Article] Secreted CXCL1 is a potential Mediator and marker of the tumor invasion of bladder cancer.2008

    • Author(s)
      Kawanishi H, Matsui Y, Ito M, Watanabe J, Takahashi T, Nishizawa K, Nishiyama H, Kamoto T, Mikami Y, Tanaka Y, Jung G, Akiyama H, Nobumasa H, Guilford P, Reeve A, Okuno Y, Tsujimoto G, Nakamura E, Ogawa O.
    • Journal Title

      Clin Cancer Res. 14

      Pages: 2578-1587

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19109001
  • [Journal Article] Establishment of the culture model system that reflects the process of terminal differentiation of connective tissue-type mast cells2008

    • Author(s)
      Takano H, Nakazawa S, Okuno Y, Shirata N, Tsuchiya S, Kainoh T, Takamatsu S, Furuta K, Taketomi Y, Naito Y, Takematsu H, Kozutsumi Y, Tsuiimoto G, Murakami M, Kudo I, Ichikawa A, Nakayama K, Sugimoto Y, Tanakag S
    • Journal Title

      FEBS Lett 582

      Pages: 1444-1450

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19109001
  • [Journal Article] Correlation index-based responsible-enzyme gene screening (CIRES), a novel DNA microarray-based method for glycan biosynthesis enzyme gene2007

    • Author(s)
      Yamamoto, H., Takematsu, H., Fujinawa, R., Naito, Y., Okuno, Y., Tsujimoto, G., Suzuki, A., Kozutsumi, Y.
    • Journal Title

      PLoS ONE 2

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18790088
  • [Journal Article] Augmentation of drug-induced cell death by ER protein BRI3BP2007

    • Author(s)
      Yamazaki, T., Sasaki, N., Nishi, M., Yamazaki, D., Ikeda, A., Okuno, Y., Komazaki, S., Takeshima, H.
    • Journal Title

      Biochem. Biophys. Res. Commun. 362

      Pages: 971-975

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18790088
  • [Journal Article] Correlation index-based responsible-enzyme gene screening (CIRES), a novel DNA microarray-based method for enzyme gene involved in glycan biosynthesis2007

    • Author(s)
      Yamamoto H, Takematsu H, Fujinawa R, Naito Y, Okuno Y, Tsujimoto G, Suzuki A, Kozutsumi Y.
    • Journal Title

      PLoS ONE 2

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19109001
  • [Journal Article] Germinal center marker GL7 probes activation-dependent repression of N-glycolylneuraminic acid, a sialic acid species involved in the negative modulation of B cell activation2007

    • Author(s)
      Naito, Y., Takematsu, H., Koyama, S., Miyake, S., Yamamoto, H., Fujinawa, R., Sugai, M., Okuno, Y., Tsujimoto, G., Yamaji, T., Hashimoto, Y., Itohara, S., Kawasaki, T., Suzuki, A., Kozutsumi, Y.
    • Journal Title

      Mol. Cell Biol 27

      Pages: 3008-3022

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18790088
  • [Journal Article] Compound-transporter interaction studies using canonical correlation analysis2007

    • Author(s)
      Kitajima, M., Minowa, Y., Matsuda, H., Okuno, Y.
    • Journal Title

      Chem-Bio Inform. J. 7

      Pages: 24-34

    • NAID

      130004138177

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18790088
  • [Journal Article] Abnormal features in mutant cerebellar Purkinje cells lacking junctophilins2007

    • Author(s)
      Ikeda, A., Miyazaki, T., Kakizawa, S., Okuno, Y., Tsuchiya, S., Myomoto, A., Saito, SY., Yamamoto, T., Yamazaki, T., Iino, M., Tsujimoto, G., Watanabe, M., Takeshima, H.
    • Journal Title

      Biochem. Biophys. Res. Commun. 363

      Pages: 835-839

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18790088
  • [Journal Article] Abnormal features in mutant cerebellar Purkinje cells lacking junctophilins2007

    • Author(s)
      Ikeda A, Miyazaki T, Kakizawa S, Okuno Y, Tsuchiya S, Myomoto A, Saito SY, Yamamoto T, Yamazaki T, Iino M, Tsujimoto G, Watanabe M, Takeshima H.
    • Journal Title

      Biochem Biophys Res Commun. 363

      Pages: 835-839

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19109001
  • [Journal Article] Germinal center marker GL7 probes activation-dependent repression of N-glycolylneuraiinic acid, a sialic acid species involved in the negative modulation of B cell activation2007

    • Author(s)
      Naito Y, Takematsu H, Koyama S, Miyake S, Yamamoto H, Fujinawa R, Sugai M, Okuno Y, Tsujimoto G, Yamaji T, Hashimoto Y, Itohara S, Kawasaki T, Suzuki A, Kozutsumi Y.
    • Journal Title

      Mol. Cell Biol.

      Pages: 3008-3022

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19109001
  • [Journal Article] Germinal center marker GL7 probes activation-dependent repression of N-glycolylneuraminic acid, a sialic acid species involved in the negative modulation of B cell activation.2007

    • Author(s)
      Naito, Y., Takematsu, H., Koyama, S., Miyake, S., Yamamoto, H., Fujinawa, R., Sugai, M., Okuno, Y., Tsujimoto, G., Yamaji, T., Hashimoto, Y., Itohara, S., Kawasaki, T., Suzuki, A., Kozutsumi, Y.
    • Journal Title

      Mol.Cell Biol. 27(8)

      Pages: 3008-3022

    • Data Source
      KAKENHI-PROJECT-18790088
  • [Journal Article] Altered gene expression of transcriptional regulatory factors in tumor marker-positive cells during chemically induced hepato carcinogenesis.2006

    • Author(s)
      Osada, S., Naganawa, A., Misonou, M., Tsuchiya, S., Tamba, S., Okuno, Y., Nishikawa, J., Satoh, K., Imagawa, I., Tsujimoto, G., Sugimoto, Y., Nishihara, T.
    • Journal Title

      Toxicology Letters 167

      Pages: 106-113

    • Data Source
      KAKENHI-PROJECT-18790088
  • [Journal Article] Altered gene expression of transcriptional regulatory factors in tumor marker-positive cells during chemically induced hepatocarcinogenesis.2006

    • Author(s)
      Osada S, Naganawa A, Misonou M, Tsuchiya S, Tamba S, Okuno Y, Nishikawa J, Satoh K, Imagawa M, Tsujimoto G, Sugimoto Y, Nishihara T
    • Journal Title

      Toxicology Letters. 167

      Pages: 106-113

    • Data Source
      KAKENHI-PROJECT-18018024
  • [Journal Article] GLIDA : GPCR-Ligand database for Chemical Genomic Drug Discovery.2006

    • Author(s)
      Okuno, Y., Yang, J., Taneishi, K., Yabuuchi, H., Tsujimoto, G.
    • Journal Title

      Nucleic Acids Research 34

    • Data Source
      KAKENHI-PROJECT-18790088
  • [Journal Article] GLIDA: GPCR-Ligand database for Chemical Genomic Drug Discovery2006

    • Author(s)
      Okuno, Y.
    • Journal Title

      Nucleic Acids Research 34

      Pages: 673-677

    • Data Source
      KAKENHI-PROJECT-16790034
  • [Journal Article] Altered gene expression of transcriptional regulatory factors in tumor marker-positive cells during chemically induced hepatocarcinogenesis.2006

    • Author(s)
      Osada S, Naganawa A, Misonou M, Tsuchiya S, Tamba S, Okuno Y, Nishikawa J, Satoh K, Imagawa M, Tsujimoto G, Sugimoto Y, Nishihara T
    • Journal Title

      Toxicology Letters. 167

      Pages: 106-113

    • Data Source
      KAKENHI-PROJECT-17659016
  • [Journal Article] GLIDA : GPCR-ligand database for chemical genomic drug discovery.2006

    • Author(s)
      Okuno Y, Yang J, Taneishi K, Yabuuchi H, Tsujimoto G
    • Journal Title

      Nucleic Acids Res. 34

      Pages: 673-677

    • Data Source
      KAKENHI-PROJECT-17659016
  • [Journal Article] GLIDA : GPCR-ligand database for chemical genomic drug discovery.2006

    • Author(s)
      Okuno Y, Yang J, Taneishi K, Yabuuchi H, Tsujimoto G
    • Journal Title

      Nucleic Acids Res. 34

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17209003
  • [Journal Article] GLIDA : GPCR-ligand database for chemical genomic drug discovery.2006

    • Author(s)
      Okuno Y
    • Journal Title

      Nucleic Acids Res. 34(Database issue)

    • Data Source
      KAKENHI-PROJECT-17209003
  • [Journal Article] MicroRNA : biogenetic and functional mechanisms and involvements in cell differentiation and cancer.2006

    • Author(s)
      Tsuchiya, S., Okuno, Y., Tsujimoto, G.
    • Journal Title

      J.Pharmacol.Sci. 101(4)

      Pages: 267-270

    • NAID

      10018236279

    • Data Source
      KAKENHI-PROJECT-18790088
  • [Journal Article] GLIDA : GPCR-ligand database for chemical genomic drug discovery.2006

    • Author(s)
      Okuno Y
    • Journal Title

      Nucleic Acids Res. 34(Database issue)

    • Data Source
      KAKENHI-PROJECT-17659016
  • [Journal Article] Comprehensive analysis of the effect of phytoestrogen, daidzein, on a testicular cell line, using mRNA and protein expression profile.2005

    • Author(s)
      Adachi T, Okuno Y, Takenaka S, Matsuda K, Ohta N, Takashima K, Yamazaki K, Nishimura D, Miyatake K, Mori C, Tsujimoto G
    • Journal Title

      Food Chem. Toxicol. 43

      Pages: 529-535

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17209003
  • [Journal Article] Inhibition of protein kinase CK2 prevents the progression of glomerulonephritis.2005

    • Author(s)
      Yamada M, Katsuma S, Adachi T, Hirasawa A, Shiojima S, Kadowaki T, Okuno Y, Koshimizu TA, Fujii S, Sekiya Y, Miyamoto Y, Tamura M, Yumura W, Nihei H, Kobayashi M, Tsujimoto G.
    • Journal Title

      Proc. Natl. Acad. Sci. U S A. Vol.102

      Pages: 7736-7741

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209003
  • [Journal Article] A probabilistic model for mining implicit 'Chemical Compound-Gene' relations from literature.2005

    • Author(s)
      Zhu S, Okuno Y, Tsujimoto G, Mamitsuka H
    • Journal Title

      Bioinformatics. 21

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17209003
  • [Journal Article] Prostaglandin E2 stimulates granulocyte colony-stimulating factor production via the prostanoid EP2 receptor in mouse peritoneal neutrophils.2005

    • Author(s)
      Sugimoto Y, Fukada Y, Mori D, Tanaka S, Yamane H, Okuno Y, Deai K, Tsuchiya S, Tsujimoto GS Ichikawa A
    • Journal Title

      J. Immunol. Vol.175

      Pages: 2606-2612

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209003
  • [Journal Article] Comprehensive analysis of the effect of phytoestrogen, daidzein, on a testicular cell line, using mRNA and protein expression profile.2005

    • Author(s)
      Adachi T, Okuno Y, Takenaka S. et al.
    • Journal Title

      Food Chem Toxicol. 43・4

      Pages: 529-535

    • Data Source
      KAKENHI-PROJECT-16790034
  • [Journal Article] Inhibition of protein kinase CK2 prevents the progression of glomerulonephritis.2005

    • Author(s)
      Yamada M, Katsuma S, Adachi T, Hirasawa A, Shiojima S, Kadowaki T, Okuno Y, Koshimizu TA, Fujii S, Sekiya Y, Miyamoto Y, Tamura M, Yumura W, Nihei H, Kobayashi M, Tsujimoto G
    • Journal Title

      Proc. Natl. Acad. Sci. USA. 102

      Pages: 7736-7741

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17209003
  • [Journal Article] Comprehensive analysis of the effect of phytoestrogen, daidzein, on a testicular cell line, using mRNA and protein expression profile.2005

    • Author(s)
      Adachi T, Okuno Y, Takenaka S, et al.
    • Journal Title

      Food Chem Toxicol. 43・4

      Pages: 529-535

    • Data Source
      KAKENHI-PROJECT-16011230
  • [Journal Article] Prostaglandin E2 stimulates granulocyte colony-stimulating factor production via the prostanoid EP2 receptor in mouse peritoneal neutrophils.2005

    • Author(s)
      Sugimoto Y, Fukada Y, Mori D, Tanaka S, Yamane H, Okuno Y, Deai K, Tsuchiya S, Tsujimoto G, Ichikawa A
    • Journal Title

      J. Immunol. 175

      Pages: 2606-2612

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17209003
  • [Journal Article] Comprehensive analysis of the effect of phytoestrogen, daidzein, on a testicular cell line, using mRNA and protein expression profile.2005

    • Author(s)
      Adachi T, Okuno Y, Takenaka S, Matsuda K, Ohta N, Takashima K, Yamazaki K, Nishimura D, Miyatake K, Mori C, Tsujimoto G
    • Journal Title

      Food Chem. Toxicol. Vol.43

      Pages: 529-535

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209003
  • [Journal Article] GPCR-ligand database for chemical genomic drug discovery.2005

    • Author(s)
      Okuno Y, Yang J, Taneishi K, Yabuuchi H, Tsujimoto G GLIDA
    • Journal Title

      Nucleic Acids Res. Vol.34

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209003
  • [Journal Article] A probabilistic model for mining implicit 'Chemical Compound-Gene' relations from literature.2005

    • Author(s)
      Zhu S, Okuno Y, Tsujimoto G, Mamitsuka H.
    • Journal Title

      Bioinformatics. Vol.21

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17209003
  • [Journal Article] Computational assignment of the EC numbers for genomic-scale analysis of enzymatic reactions.2004

    • Author(s)
      Kotera M, Okuno Y, Hattori M, Goto S, Kanehisa M.
    • Journal Title

      J Am Chem Soc. 126・50

      Pages: 16487-16498

    • Data Source
      KAKENHI-PROJECT-16790034
  • [Journal Article] Computational assignment of the EC numbers for genomic-scale analysis of enzymatic reactions2004

    • Author(s)
      Kotera, M., Okuno, Y., Hattori, M., Goto, S., Kanehisa, M.
    • Journal Title

      J.Am.Chem.Soc. 126

      Pages: 16487-16498

    • Data Source
      KAKENHI-PROJECT-12208007
  • [Journal Article] Microarray evaluation of EP4 receptor- mediated prostaglandin E2 suppression of 3T3-L1 adipocyte differentiation.2004

    • Author(s)
      Sugimoto Y, Tsuboi H, Okuno Y, Tamba S, et al.
    • Journal Title

      Biochem Biophys Res Commun. 323・3

      Pages: 911-917

    • Data Source
      KAKENHI-PROJECT-16011230
  • [Journal Article] Computational assignment of the EC numbers for genomic-scale analysis of enzymatic reactions.2004

    • Author(s)
      Kotera M, Okuno Y, Hattori M, Goto S, Kanehisa M.
    • Journal Title

      J Am Chem Soc. 126・50

      Pages: 16487-16498

    • Data Source
      KAKENHI-PROJECT-16011230
  • [Journal Article] Microarray evaluation of EP4 receptor-mediated prostaglandin E2 suppression of 3T3-L1 adipocyte differentiation.2004

    • Author(s)
      Sugimoto Y, Tsuboi H, Okuno Y, Tamba S. et al.
    • Journal Title

      Biochem Biophys Res Commun. 322・3

      Pages: 911-917

    • Data Source
      KAKENHI-PROJECT-16790034
  • [Patent] ESTIMATION OF PROTEIN-COMPOUND IN TERACTION AND RATIONAL DESIGN OF COMPOUND LIBRARY BASED ON CHEMICAL GENOMIC INFORMATION2008

    • Inventor(s)
      奥野恭史,種石 慶,辻本豪三
    • Industrial Property Rights Holder
      国立大学法人京都大学
    • Filing Date
      2008-11-20
    • Overseas
    • Data Source
      KAKENHI-PROJECT-18790088
  • [Patent] マイクロRNA標的遺伝子予測装置2007

    • Inventor(s)
      奥野恭史, 他6名
    • Industrial Property Rights Holder
      東レ(株)
    • Industrial Property Number
      2007-053322
    • Filing Date
      2007-03-02
    • Data Source
      KAKENHI-PROJECT-18790088
  • [Patent] マイクロRNA標的遺伝子予測装置2007

    • Inventor(s)
      奥野 恭史, 辻本 豪三, 他5名
    • Industrial Property Rights Holder
      東レ(株)
    • Industrial Property Number
      2007-053322
    • Filing Date
      2007-03-02
    • Data Source
      KAKENHI-PROJECT-17659016
  • [Patent] ケミカルゲノム情報に基づく、タンパク質-化合物相互作用の予測と化合物ライブラリーの合理的設計2006

    • Inventor(s)
      奥野恭史, 他2名
    • Industrial Property Rights Holder
      京都大学
    • Industrial Property Number
      2006-147433
    • Filing Date
      2006-05-26
    • Data Source
      KAKENHI-PROJECT-18790088
  • [Patent] データ処理装置、データ処理プログラム、それを格納したコンピュータ読み取り可能な記録媒体、およびデータ処理方法2006

    • Inventor(s)
      奥野恭史, 他3名
    • Industrial Property Rights Holder
      京都大学
    • Patent Publication Number
      2007-011752
    • Filing Date
      2006-06-28
    • Data Source
      KAKENHI-PROJECT-18790088
  • [Patent] データ処理装置、データ処理プログラム、それを格納したコンピュータ読み取り可能な記録媒体、およびデータ2005

    • Inventor(s)
      辻本 豪三, 奥野 恭史, 梁智允, 種石慶
    • Industrial Property Rights Holder
      国立大学法人京都大学
    • Industrial Property Number
      2005-192675
    • Filing Date
      2005-06-30
    • Data Source
      KAKENHI-PROJECT-17209003
  • [Patent] データ処理装置、データ処理プログラム、それを格納したコンピュータ読み取り可能な記録媒体、およびデータ処理方法2005

    • Inventor(s)
      奥野 恭史
    • Industrial Property Rights Holder
      京都大学
    • Industrial Property Number
      2005-192675
    • Filing Date
      2005-06-30
    • Data Source
      KAKENHI-PROJECT-16790034
  • [Patent] データ処理装置、データ処理プログラム、それを格納したコンピュータ読み取り可能な記録媒体、およびデータ2005

    • Inventor(s)
      辻本 豪三, 奥野 恭史, 梁智允, 種石慶
    • Industrial Property Rights Holder
      国立大学法人京都大学
    • Industrial Property Number
      2005-192675
    • Filing Date
      2005-06-30
    • Data Source
      KAKENHI-PROJECT-17659016
  • [Patent] データ処理装置、データ処理プログラム、それを格納したコンピュータ読み取り可能な記録媒体、およびデータ2005

    • Inventor(s)
      辻本豪三, 奥野恭史, 梁智允, 種石慶
    • Industrial Property Rights Holder
      国立大学法人京都大学
    • Industrial Property Number
      2005-192675
    • Filing Date
      2005-06-30
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17209003
  • [Presentation] Chemical genomic analysis of cross-reactivity in endogenous GPCR-mediated pathways2012

    • Author(s)
      A. Shiraishi, S. Niijima, Y. Okuno
    • Organizer
      3rd Strasbourg Summer School in Chemoinformatics
    • Place of Presentation
      Universite de Strasbourg (Strasbourg, France)
    • Year and Date
      2012-06-25
    • Data Source
      KAKENHI-PLANNED-23136102
  • [Presentation] Dissecting kinase profiling data to predict activity and understand cross-reactivity of kinase inhibitors2012

    • Author(s)
      S. Niijima, A. Shiraishi, Y. Okuno
    • Organizer
      3rd Strasbourg Summer School in Chemoinformatics
    • Place of Presentation
      Universite de Strasbourg (Strasbourg, France)
    • Year and Date
      2012-06-25
    • Data Source
      KAKENHI-PLANNED-23136102
  • [Presentation] 信頼性・操作性に優れた医薬品有害事象解析システムの開発2011

    • Author(s)
      藪内弘昭, 奥野恭史, (他7名)
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      静岡県立大学 他(静岡県)
    • Data Source
      KAKENHI-PROJECT-22681031
  • [Presentation] 有害事象自発報告データベースを用いた白金系抗がん剤の過敏症反応の解析2011

    • Author(s)
      角山香織, 新島聡, 藪内弘昭, 奥野恭史, 栄田敏之
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      静岡県立大学 他(静岡県)
    • Data Source
      KAKENHI-PLANNED-22136012
  • [Presentation] 信頼性・操作性に優れた医薬品有害事象解析システムの開発2011

    • Author(s)
      藪内弘昭, 奥野恭史, (他7名)
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      静岡県立大学 他(静岡県)
    • Data Source
      KAKENHI-PROJECT-21659009
  • [Presentation] 有害事象自発報告データベースを用いた白金系抗がん剤の過敏症反応の解析2011

    • Author(s)
      角山香織, 新島聡, 藪内弘昭, 奥野恭史, 栄田敏之
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      静岡県立大学 他(静岡県)
    • Data Source
      KAKENHI-PROJECT-22681031
  • [Presentation] 有害事象自発報告データベースを用いた白金系抗がん剤の過敏症反応の解析2011

    • Author(s)
      角山香織, 新島聡, 藪内弘昭, 奥野恭史, 栄田敏之
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      静岡県立大学 他(静岡県)
    • Data Source
      KAKENHI-PROJECT-21659009
  • [Presentation] 信頼性・操作性に優れた医薬品有害事象解析システムの開発2011

    • Author(s)
      藪内弘昭, 奥野恭史, (他7名)
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      静岡県立大学 他(静岡県)
    • Data Source
      KAKENHI-PLANNED-22136012
  • [Presentation] Chemical genomics based approach for prediction of GPCR agonists/antagonists2010

    • Author(s)
      白石慧, 新島聡, 奥野恭史
    • Organizer
      2010年日本バイオインフォマティクス学会年会
    • Place of Presentation
      九州大学医学部百年講堂(福岡県)
    • Year and Date
      2010-12-13
    • Data Source
      KAKENHI-PLANNED-22136012
  • [Presentation] Reverse Polypharmacology to explore novel bioactive molecules2010

    • Author(s)
      J.B.Brown, Yasushi Okuno
    • Organizer
      The International Chemical Congress of Pacific Basin Societies (PacifiChem 2010)
    • Place of Presentation
      Honolulu(Hawaii)(招待講演)
    • Year and Date
      2010-12-18
    • Data Source
      KAKENHI-PROJECT-22681031
  • [Presentation] Gene profile of electroconvulsive seizures of the paraventricular nucleus of hypothalamus2010

    • Author(s)
      瀬木(西田)恵里, 坂井田真理, 土屋創建, 杉本幸彦, 奥野恭史
    • Organizer
      第33回日本神経科学大会
    • Place of Presentation
      神戸コンベンションセンター(兵庫県)
    • Year and Date
      2010-09-02
    • Data Source
      KAKENHI-PLANNED-22136012
  • [Presentation] Data mining of multiple compound-protein interactions for drug discovery2010

    • Author(s)
      奥野恭史
    • Organizer
      第33回情報化学討論会
    • Place of Presentation
      徳島大学(徳島県)(招待講演)
    • Year and Date
      2010-10-31
    • Data Source
      KAKENHI-PROJECT-21659009
  • [Presentation] Data mining of multiple compound-protein interactions for drug discovery2010

    • Author(s)
      奥野恭史
    • Organizer
      第33回情報化学討論会
    • Place of Presentation
      徳島大学(徳島県)(招待講演)
    • Year and Date
      2010-10-31
    • Data Source
      KAKENHI-PLANNED-22136012
  • [Presentation] Gene profile of electroconvulsive seizures of the paraventricular nucleus of hypothalamus2010

    • Author(s)
      瀬木(西田)恵里, 坂井田真理, 土屋創建, 杉本幸彦, 奥野恭史
    • Organizer
      第33回日本神経科学大会
    • Place of Presentation
      神戸コンベンションセンター(兵庫県)
    • Year and Date
      2010-09-02
    • Data Source
      KAKENHI-PROJECT-21659009
  • [Presentation] Reverse Polypharmacology to explore novel bioactive molecules2010

    • Author(s)
      J.B.Brown, Yasushi Okuno
    • Organizer
      The International Chemical Congress of Pacific Basin Societies (PacifiChem 2010)
    • Place of Presentation
      Honolulu (Hawaii)(招待講演)
    • Year and Date
      2010-12-18
    • Data Source
      KAKENHI-PLANNED-22136012
  • [Presentation] Chemical Space Travel:インフォマティクスによる包括的な活性化合物探索2010

    • Author(s)
      奥野恭史
    • Organizer
      株式会社ペプチド研究所
    • Place of Presentation
      ペプチド研究所 彩都研究所(大阪府)(特別講演(招待講演))
    • Year and Date
      2010-10-15
    • Data Source
      KAKENHI-PLANNED-22136012
  • [Presentation] Reverse Polypharmacology to explore novel bioactive molecules2010

    • Author(s)
      J.B.Brown, Yasushi Okuno
    • Organizer
      The International Chemical Congress of Pacific Basin Societies (PacifiChem 2010)
    • Place of Presentation
      Honolulu (Hawaii)(招待講演)
    • Year and Date
      2010-12-18
    • Data Source
      KAKENHI-PROJECT-21659009
  • [Presentation] 分子標的創薬からシステム創薬へ2010

    • Author(s)
      奥野恭史
    • Organizer
      CBI学会2010年大会
    • Place of Presentation
      学術総合センター一橋記念講堂(東京都)(招待講演)
    • Year and Date
      2010-09-16
    • Data Source
      KAKENHI-PROJECT-22681031
  • [Presentation] Chemical genomics based approach for prediction of GPCR agonists/antagonists2010

    • Author(s)
      白石慧, 新島聡, 奥野恭史
    • Organizer
      2010年日本バイオインフォマティクス学会年会
    • Place of Presentation
      九州大学医学部百年講堂(福岡県)
    • Year and Date
      2010-12-13
    • Data Source
      KAKENHI-PROJECT-22681031
  • [Presentation] Gene profile of electroconvulsive seizures of the paraventricular nucleus of hypothalamus2010

    • Author(s)
      瀬木(西田)恵里, 坂井田真理, 土屋創建, 杉本幸彦, 奥野恭史
    • Organizer
      第33回日本神経科学大会
    • Place of Presentation
      神戸コンベンションセンター(兵庫県)
    • Year and Date
      2010-09-02
    • Data Source
      KAKENHI-PROJECT-22681031
  • [Presentation] Data mining of multiple compound-protein interactions for drug discovery2010

    • Author(s)
      奥野恭史
    • Organizer
      第33回情報化学討論会
    • Place of Presentation
      徳島大学(徳島県)(招待講演)
    • Year and Date
      2010-10-31
    • Data Source
      KAKENHI-PROJECT-22681031
  • [Presentation] ケミカルゲノミクスがもたらす多分子対多分子の多重相互作用とその創薬への可能性2010

    • Author(s)
      奥野恭史
    • Organizer
      サントリー生物有機科学研究所セミナー・コロキウム
    • Place of Presentation
      サントリー生物有機科学研究所(大阪府)(招待講演)
    • Year and Date
      2010-05-25
    • Data Source
      KAKENHI-PLANNED-22136012
  • [Presentation] Chemical genomics based approach for prediction of GPCR agonists/antagonists2010

    • Author(s)
      白石慧, 新島聡, 奥野恭史
    • Organizer
      2010年日本バイオインフォマティクス学会年会
    • Place of Presentation
      九州大学医学部百年講堂(福岡県)
    • Year and Date
      2010-12-13
    • Data Source
      KAKENHI-PROJECT-21659009
  • [Presentation] Chemical Space Travel:インフォマティクスによる包括的な活性化合物探索2010

    • Author(s)
      奥野恭史
    • Organizer
      株式会社ペプチド研究所 特別講演
    • Place of Presentation
      ペプチド研究所 彩都研究所(大阪府)(招待講演)
    • Year and Date
      2010-10-15
    • Data Source
      KAKENHI-PROJECT-22681031
  • [Presentation] ケミカルゲノミクスがもたらす多分子対多分子の多重相互作用とその創薬への可能性2010

    • Author(s)
      奥野恭史
    • Organizer
      サントリー生物有機科学研究所セミナー・コロキウム
    • Place of Presentation
      サントリー生物有機科学研究所(大阪府)(招待講演)
    • Year and Date
      2010-05-25
    • Data Source
      KAKENHI-PROJECT-22681031
  • [Presentation] Fragment-based de novo design of bioactive compounds by particle swarm optimization2010

    • Author(s)
      諧肇, 金井千里, 奥野恭史
    • Organizer
      情報計算化学生物学会(CBI学会)2010年大会
    • Place of Presentation
      学術総合センター一橋記念講堂(東京都)
    • Year and Date
      2010-09-16
    • Data Source
      KAKENHI-PROJECT-22681031
  • [Presentation] Fragment-based de novo design of bioactive compounds by particle swarm optimization2010

    • Author(s)
      諧肇, 金井千里, 奥野恭史
    • Organizer
      情報計算化学生物学会(CBI学会)2010年大会
    • Place of Presentation
      学術総合センター一橋記念講堂(東京都)
    • Year and Date
      2010-09-16
    • Data Source
      KAKENHI-PROJECT-21659009
  • [Presentation] 分子標的創薬からシステム創薬へ2010

    • Author(s)
      奥野恭史
    • Organizer
      CBI学会2010年大会
    • Place of Presentation
      学術総合センター一橋記念講堂(東京都)(招待講演)
    • Year and Date
      2010-09-16
    • Data Source
      KAKENHI-PLANNED-22136012
  • [Presentation] 分子標的創薬からシステム創薬へ2010

    • Author(s)
      奥野恭史
    • Organizer
      CBI学会2010年大会
    • Place of Presentation
      学術総合センター一橋記念講堂(東京都)(招待講演)
    • Year and Date
      2010-09-16
    • Data Source
      KAKENHI-PROJECT-21659009
  • [Presentation] Chemical Space Travel:インフォマティクスによる包括的な活性化合物探索2010

    • Author(s)
      奥野恭史
    • Organizer
      株式会社ペプチド研究所
    • Place of Presentation
      ペプチド研究所 彩都研究所(大阪府)(特別講演 招待講演)
    • Year and Date
      2010-10-15
    • Data Source
      KAKENHI-PROJECT-21659009
  • [Presentation] Fragment-based de novo design of bioactive compounds by particle swarm optimization2010

    • Author(s)
      諧肇, 金井千里, 奥野恭史
    • Organizer
      情報計算化学生物学会(CBI学会)2010年大会
    • Place of Presentation
      学術総合センター一橋記念講堂(東京都)
    • Year and Date
      2010-09-16
    • Data Source
      KAKENHI-PLANNED-22136012
  • [Presentation] ケミカルゲノミクスがもたらす多分子対多分子の多重相互作用とその創薬への可能性2010

    • Author(s)
      奥野恭史
    • Organizer
      サントリー生物有機科学研究所セミナー・コロキウム
    • Place of Presentation
      サントリー生物有機科学研究所(大阪府)(招待講演)
    • Year and Date
      2010-05-25
    • Data Source
      KAKENHI-PROJECT-21659009
  • [Presentation] 医薬品-疾病作用情報データベース2009

    • Author(s)
      荒木通啓,馮春来,多門啓子,薮内弘昭,奥野恭史
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都
    • Year and Date
      2009-03-27
    • Data Source
      KAKENHI-PROJECT-18790088
  • [Presentation] 統合型薬学情報ナビゲーションシステムの開発2009

    • Author(s)
      多門啓子,牧口大旭,荒木通啓,薮内弘昭,奥野恭史,金子周司
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都
    • Year and Date
      2009-03-27
    • Data Source
      KAKENHI-PROJECT-18790088
  • [Presentation] 新規in silicoヌクリーニング手法CGBVSのためのGPCRカーネルの改良2009

    • Author(s)
      藪内弘昭,新島聡,奥野恭史
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都
    • Year and Date
      2009-03-26
    • Data Source
      KAKENHI-PROJECT-18790088
  • [Presentation] A Web Tool for Expression Pattern-Based Data Retrieval and Relevant Network Discovery from Vast Public Microarray Database2009

    • Author(s)
      Feng, C., Araki, H., Kunimoto, R., Tamon, A., Makiguchi, H., Niijima, S., Tsuiimoto, G., Okuno, Y.
    • Organizer
      20th International Conference on Genome Informatics (GIW 2009)
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-21659009
  • [Presentation] ケミカルゲノミクス情報を用いた標的タンパク質の予測法の開発2009

    • Author(s)
      藤田淳人,藪内弘昭,小川哲平,荒木通啓,大石真也,藤井信孝,中山和久,奥野恭史
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都
    • Year and Date
      2009-03-27
    • Data Source
      KAKENHI-PROJECT-18790088
  • [Presentation] 遺伝子発現プロファイルに基づいたマイクロアレイデータ検索システム(GEMTREND)2009

    • Author(s)
      馮春来,荒木通啓,国本亮,多門啓子,牧口大旭,新島聡,辻本豪三,奥野恭史
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都
    • Year and Date
      2009-03-27
    • Data Source
      KAKENHI-PROJECT-18790088
  • [Presentation] 数理的手法に基づく化合物-タンパク質間相互作用様式に関わる知識発見2009

    • Author(s)
      新島聡,藪内弘昭,藤井信孝,奥野恭史
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都
    • Year and Date
      2009-03-27
    • Data Source
      KAKENHI-PROJECT-18790088
  • [Presentation] GLIDA:ケミカルゲノミクスに基づく化合物探索を目的としたGPCR-リガンド相互作用解析データベース2008

    • Author(s)
      多門啓子,藪内弘昭,新島 聡,箕輪洋介,外村孝一郎,国本 亮,馮 春来,奥野恭史
    • Organizer
      第5回バイオメディカル研究会
    • Place of Presentation
      大阪
    • Year and Date
      2008-02-13
    • Data Source
      KAKENHI-PROJECT-18790088
  • [Presentation] Network analysis approach for elucidating the mechanism of drug toxicity using time- and dose-dependent microarray data2008

    • Author(s)
      Tonomura, K., Niijima, S., Tsujimoto, G., Fujii, N., Okuno, Y.
    • Organizer
      2008 Annual Conference of Japanese Society for Bioinformatics (JSBi2008)
    • Place of Presentation
      大阪
    • Year and Date
      2008-12-15
    • Data Source
      KAKENHI-PROJECT-18790088
  • [Presentation] Evaluation of a chemical genomics-based virtual screening2008

    • Author(s)
      Yabuuchi, H., Niijima, S., Okuno, Y.
    • Organizer
      CBI2008年大会
    • Place of Presentation
      東京
    • Year and Date
      2008-10-22
    • Data Source
      KAKENHI-PROJECT-18790088
  • [Presentation] CCA空間モデルを用いた化合物-CYP相互作用予測モデルの構築2008

    • Author(s)
      小川哲平,箕輪洋介,足達哲也,馮 春来,新島聡,大石真也,藤井信孝,奥野恭史
    • Organizer
      第5回バイオメディカル研究会
    • Place of Presentation
      大阪
    • Year and Date
      2008-02-13
    • Data Source
      KAKENHI-PROJECT-18790088
  • [Presentation] GEM-TREND : a web tool for gene expression data mapping toward relevant network discovery2008

    • Author(s)
      馮 春来,多門啓子,牧口大旭,新島 聡,国本 亮,小川哲平,外村孝一郎,奥野恭史
    • Organizer
      第5回バイオメディカル研究会
    • Place of Presentation
      大阪
    • Year and Date
      2008-02-13
    • Data Source
      KAKENHI-PROJECT-18790088
  • [Presentation] 化合物-タンパク質相互作用情報に基づく新規in silico化合物探索手法の開発2008

    • Author(s)
      小川哲平,北島正人,箕輪洋介,松田秀雄,藤井信孝,奥野恭史
    • Organizer
      日本薬学会第128年会
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-26
    • Data Source
      KAKENHI-PROJECT-18790088
  • [Presentation] Comprehensive analysis of time-course and dose-response toxicogenomics data2008

    • Author(s)
      新島聡,奥野恭史,藤井信孝
    • Organizer
      第5回バイオメディカル研究会
    • Place of Presentation
      大阪
    • Year and Date
      2008-02-13
    • Data Source
      KAKENHI-PROJECT-18790088
  • [Presentation] GLIDA:ケミカルゲノミクスに基づくドラッグ探索のためのGPCR-リガンド相互作用解析データベース2008

    • Author(s)
      多門啓子,藪内弘昭,新島聡,箕輪洋介,外村孝一郎,国本亮,馮 春来,奥野恭史
    • Organizer
      日本薬学会第128年会
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-26
    • Data Source
      KAKENHI-PROJECT-18790088
  • [Presentation] Laplacian linear discriminant analysis approach to unsupervised feature selection2008

    • Author(s)
      Niijima, S. and Okuno, Y.
    • Organizer
      6th Asia Pacific Bioinformatics Conference (APBC2008)
    • Place of Presentation
      京都
    • Year and Date
      2008-01-14
    • Data Source
      KAKENHI-PROJECT-18790088
  • [Presentation] Prediction of drug - Cytochrome P450 interaction using chemical-biological correlation space model2007

    • Author(s)
      Ogawa, T., Minowa, Y., Adachi, T., Feng, C., Niijima, S., Oishi, S., Eujii, N., Okuno, Y.
    • Organizer
      CBI2007年大会
    • Place of Presentation
      広島
    • Year and Date
      2007-10-03
    • Data Source
      KAKENHI-PROJECT-18790088
  • [Presentation] ケミカルゲノミクス情報を利用したGPCRのin silicoリガンド探索手法の開発2007

    • Author(s)
      奥野恭史
    • Organizer
      日本ケミカルバイオロジー研究会第2回年会
    • Place of Presentation
      京都
    • Year and Date
      2007-05-10
    • Data Source
      KAKENHI-PROJECT-18790088
  • [Presentation] Matrix factorization approach to identify and interpret time- and dose-d ependent gene expression patterns2007

    • Author(s)
      Niijima, S., Okuno, Y., Fujii, N.
    • Organizer
      2007 Annual Conference of Japanese Society for Bioinformatics (JSBi2007)
    • Place of Presentation
      東京
    • Year and Date
      2007-12-17
    • Data Source
      KAKENHI-PROJECT-18790088
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