Shiiba Masashi 椎葉正史

… Alternative Names

SHIIBA Masashi 椎葉正史

椎葉正史シイバマサシ

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Researcher Number	20301096
Other IDs
Affiliation (Current)	2025: 東京大学, 医学部附属病院, 病院診療医(出向)
Affiliation (based on the past Project Information) *help	2016 – 2023: 千葉大学, 大学院医学研究院, 准教授 2012 – 2015: 千葉大学, 医学(系)研究科(研究院), 准教授 2012: 千葉大学, 大学院・医学研究院, 准教授 2009 – 2011: Chiba University, 医学部附属病院, 講師 2007 – 2009: 千葉大学, 大学院・医学研究院, 講師 2002 – 2004: 千葉大学, 大学院・医学研究院, 助手 1999: 千葉大学, 医学部・附属病院, 助手
Review Section/Research Field	Principal Investigator Surgical dentistry / Basic Section 57060:Surgical dentistry-related Except Principal Investigator Basic Section 57060:Surgical dentistry-related / Surgical dentistry / Surgical dentistry / Basic Section 53030:Respiratory medicine-related
Keywords	Principal Investigator 口腔癌 / 口腔扁平上皮癌 / マイクロアレイ解析 / miRNA / long non coding RNA / stathmin / maspin / H3K27 / Chip-seq法 / スーパーエンハンサー(SE) … More / エピジェネティックな修飾 / H3K27ac / 機能特異性 / 疾患特異性 / 組織特異性 / ChIP-seq 法 / スーパーエンハンサー / lncRNA / 抗がん剤耐性試験 / 抗がん剤・放射線耐性 / 抗癌剤耐性試験 / 放射線耐性試験 / 腫瘍の浸潤・転移能 / 共培養 / LINC00256A / UCA1 / pleomorphic adenoma / squamous cell carcinoma / salivary gland tumor / microarray analysis / oral cancer / 遺伝子クローニング / 腺癌 / 遺伝子発現プロファイリング / cDNA / マイクロアレイ / 庸平上皮癌 / 遺伝子機能評価 / 扁平上皮癌 / 唾液腺癌 / Aly/REF / 腫瘍 / 浸潤・転移 / がん遺伝子 / 発がん / long non-coding RNA / long non-cording RNA / アルドース‐ケトース還元酵素（AKR） / メフェナム酸 / 抗癌剤耐性 / アルドケトース還元酵素(AKR) / 抗癌剤多剤耐性遺伝子 / アルドースケトース還元酵素 / 癌関連遣伝子 / micro RNA / 癌関連遺伝子 / microRNA … More Except Principal Investigator 口腔癌 / DNA methyltransferase / 口腔扁平上皮癌 / DNA methylation / 克服薬 / 薬剤耐性機構 / 微小管阻害薬剤 / 化学療法 / 頭頚部悪性腫瘍 / 微小管阻害抗癌剤 / 頭頸部扁平上皮がん / 分子標的治療 / 肺がん / 口腔がん / EPSTI1 / 上皮間葉移行 / 腺様のう胞がん / 唾液腺タイプがん / 唾液導管がん / 粘表皮がん / 腺様囊胞がん / 唾液腺タイプ腫瘍 / 口腔扁平上皮がん / 肺扁平上皮がん / 扁平上皮がん / KOマウス / ナノインデンテーション試験 / クロスリンク解析 / Plod2 / GFP標識癌細胞 / 転移モデル / 低酸素応答 / HIF1-α / HIF-1α / コラーゲンクロスリンク / 胎生致死 / LH2 / PLOD2 / CRISPR/Cas9 / ノックアウトマウス / survivin / KAI1 gene / FEZ1 gene / p16 gene / APC gene / oral squamous cell carcinoma / p73遺伝子 / FEZ1遺伝子 / APC遺伝子 / p16遺伝子 / CDKN2A / 腺癌 / 5-Aza-C / 細胞周期関連遺伝子 / methyltransferase / MyoD family遺伝子 / 筋再生 / 脂肪幹細胞 / MyoD family 遺伝子 / シンドビスウイルス / drug delivery system / リボソーム / 腫瘍特異性 / リポソーム / 腫瘍特異的吸着 / ウイルスカプシド / 低病原性ウイルス / 臨床腫瘍学 / 免疫療法 / 養子免疫療法 / ワクチン療法 / 扁平上皮癌 / 腫瘍拒絶抗原 / ケラチン遺伝子 / 完全長cDNAライブラリー / 舌癌 Less

Molecular analysis and overcoming of drug resistance to microtubule inhibitors
- Principal Investigator
  
  伏見一章
- Project Period (FY)
  2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Chiba University
CRISPRスクリーニング法を用いたセツキシマブ耐性分子機構の解明
- Principal Investigator
  
  小池一幸
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Chiba University
Development of molecular targeted therapy for pulmonary squamous cell carcinoma
- Principal Investigator
  
  Takiguchi Yuichi
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Chiba University
口腔癌悪性度を決定するスーパーエンハンサーによる系統的転写制御機構の解明Principal Investigator
- Principal Investigator
  
  椎葉正史
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Chiba University
Evaluate changes in collagen cross-linking in lysyl hydroxylase 2 knockout mice and elucidate the role of PLOD2 in cancer metastasis
- Principal Investigator
  
  Nakashima Dai
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Chiba University
Development of novel therapy based on functions of long non coding RNA in the cancer and cancer-associated cellsPrincipal Investigator
- Principal Investigator
  
  SHIIBA Masashi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  Chiba University
Regeneration of muscle by introduction of MyoD family gene into adipose-derived stem cells
- Principal Investigator
  
  SAKAMOTO Yousuke
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  Chiba University
Control mechanism elucidation of the Wnt pathway, extracellular matrix by the CD82 and the development of cancer metastasis inhibitorPrincipal Investigator
- Principal Investigator
  
  SHIIBA MASASHI
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Surgical dentistry
- Research Institution
  Chiba University
Studies of the clinical significance and the role of long non coding RNA in oral cancer.Principal Investigator
- Principal Investigator
  
  SHIIBA MASASHI
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  Chiba University
Development of enhancement chemotherapy by overcoming an anti-cancer resistant mechanism of AKR1C familyPrincipal Investigator
- Principal Investigator
  
  SHIIBA Masashi
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Surgical dentistry
- Research Institution
  Chiba University
Functional analysis of microRNA in oral carcinoma.Principal Investigator
- Principal Investigator
  
  SHIIBA Masashi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  Chiba University
Development of cancer-targeted liposome with viral proteins
- Principal Investigator
  
  UZAWA Katsuhiro
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  Chiba University
Search for oral cancer specific genes and molecular cloning using in-house cDNA microarayPrincipal Investigator
- Principal Investigator
  
  SHIBA Masashi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  Chiba University
Study on the role of DNA methyltransferases in regulation of the expression of genes associated with the control of cell cycle
- Principal Investigator
  
  BUKAWA Hiroki
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  Chiba University
腫瘍拒絶抗原分子による口腔癌の免疫療法の確立
- Principal Investigator
  
  大越基弘
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Surgical dentistry
- Research Institution
  The University of Tokyo

All 2023 2020 2010 2009 2008

All Journal Article Presentation Patent

[Journal Article] Survival Impact of Second-Line Immune Checkpoint Inhibitors in Older Patients With Advanced Squamous-Cell NSCLC: Post Hoc Analysis of the CAPITAL Study2023
- Author(s)
  Kogure Yoshihito、Kada Akiko、Hashimoto Hiroya、Atagi Shinji、Takiguchi Yuichi、Saka Hideo、Ebi Noriyuki、Inoue Akira、Kurata Takayasu、Fujita Yuka、Nishii Yoichi、Itani Hidetoshi、Endo Takeo、Saito Akiko M.、Shibayama Takuo、Yamamoto Nobuyuki、Gemma Akihiko
- Journal Title
  
  JTO Clinical and Research Reports
  
  Volume: 4 Issue: 6 Pages: 100514-100514
- DOI
  10.1016/j.jtocrr.2023.100514
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08561
[Journal Article] Oncolytic activity of Sindbis virus in human oral squamous carcinoma cells2009
- Author(s)
  Saito K, Uzawa K, Kasamatsu A, Shinozuka K, Sakuma K, Yamatoji M, Shiiba M, Shino Y, Shirasawa H, Tanzawa H
- Journal Title
  
  Br J Cancer 101(4)
  
  Pages: 684-90
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390508
[Journal Article] Oncolytic virotherapy for oral squamous cell carcinoma using replication-competent viruses2009
- Author(s)
  Saito K, Shirasawa H, Isegawa N, Shiiba M, Uzawa K, Tanzawa H
- Journal Title
  
  Oral Oncology 45(12)
  
  Pages: 1021-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390508
[Patent] 腫瘍特異性を有する新型リポソーム2010
- Inventor(s)
  鵜沢一弘, 齋藤謙悟, 丹沢秀樹, 白澤浩, 山本惠司, 森部久仁一, 椎葉正史
- Industrial Property Rights Holder
  千葉大学
- Industrial Property Number
  2010-086071
- Filing Date
  2010-04-02
- Data Source
  KAKENHI-PROJECT-19390508
[Presentation] Epithelial-stromal interaction 1 (EPSTI1) in human oral and lung squamous cell carcinomas2020
- Author(s)
  Fan, M. Arai, M. Tawada, A. Chiba, T. Fukushima, R. Uzawa, K. Shiiba, M. Kato, N. Takiguchi, Y.
- Organizer
  The 79th Annual Meeting of the Japanese Cancer Asssociation
- Data Source
  KAKENHI-PROJECT-20K08561
[Presentation] Oncolytic activity of sindbis virus for oral cancer cells2008
- Author(s)
  Saito k., Shirasawa H., Shiiba M., Uzawa K., Tanzawa H
- Organizer
  3th World Congress on Advances in Oncology and 11th International Symposium on Molecular Medicine
- Place of Presentation
  Greece Krete
- Data Source
  KAKENHI-PROJECT-19390508

1. UZAWA Katsuhiro (30302558)

# of Collaborated Projects: 4 results

# of Collaborated Products: 3 results
2. TANZAWA HIDEKI (50236775)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. KASAMATSU ATSUSHI (60375730)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
4. BUKAWA Hiroki (80173558)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. SHIRASAWA Hiroshi (00216194)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
6. SAITO Kengo (70451755)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
7. SAKAMOTO Yousuke (50451745)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. OGAWARA KATSUNORI (20372360)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. Nakashima Dai (50431747)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. 小池一幸 (10618060)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. YOKOE Hidetaka (70261930)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. SEKI Naohiko (50345013)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. TAKIGUCHI Masaki (40179578)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. Takiguchi Yuichi (30272321)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 大越基弘 (80022888)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 森良之 (70251296)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 神津由直 (70400942)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 小池博文 (10595995)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 皆川康之 (30639787)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 太和田暁之 (10596159)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
21. 新井誠人 (30396684)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
22. 伏見一章 (90375733)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. TAKIGUCHI Yuuichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Shiiba Masashi 椎葉 正史

SHIIBA Masashi 椎葉 正史

椎葉 正史 シイバ マサシ

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口腔癌悪性度を決定するスーパーエンハンサーによる系統的転写制御機構の解明Principal Investigator

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Development of novel therapy based on functions of long non coding RNA in the cancer and cancer-associated cellsPrincipal Investigator

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Control mechanism elucidation of the Wnt pathway, extracellular matrix by the CD82 and the development of cancer metastasis inhibitorPrincipal Investigator

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Studies of the clinical significance and the role of long non coding RNA in oral cancer.Principal Investigator

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Development of enhancement chemotherapy by overcoming an anti-cancer resistant mechanism of AKR1C familyPrincipal Investigator

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Functional analysis of microRNA in oral carcinoma.Principal Investigator

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Search for oral cancer specific genes and molecular cloning using in-house cDNA microarayPrincipal Investigator

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Shiiba Masashi 椎葉正史

SHIIBA Masashi 椎葉正史

椎葉正史シイバマサシ