Shiiba Masashi 椎葉正史

… Alternative Names

SHIIBA Masashi 椎葉正史

椎葉正史シイバマサシ

Less

Researcher Number	20301096
Other IDs
Affiliation (Current)	2023: 東京大学, 医学部附属病院, 准教授
Affiliation (based on the past Project Information) *help	2016 – 2021: 千葉大学, 大学院医学研究院, 准教授 2012 – 2015: 千葉大学, 医学(系)研究科(研究院), 准教授 2012: 千葉大学, 大学院・医学研究院, 准教授 2009 – 2011: Chiba University, 医学部附属病院, 講師 2007 – 2009: 千葉大学, 大学院・医学研究院, 講師 2002 – 2004: 千葉大学, 大学院・医学研究院, 助手 1999: 千葉大学, 医学部・附属病院, 助手
Review Section/Research Field	Principal Investigator Surgical dentistry / Basic Section 57060:Surgical dentistry-related Except Principal Investigator Basic Section 57060:Surgical dentistry-related / Surgical dentistry / Surgical dentistry / Basic Section 53030:Respiratory medicine-related
Keywords	Principal Investigator 口腔癌 / マイクロアレイ解析 / 口腔扁平上皮癌 / maspin / stathmin / long non coding RNA / miRNA / microRNA / 癌関連遺伝子 / micro RNA … More / 癌関連遣伝子 / アルドースケトース還元酵素 / 抗癌剤多剤耐性遺伝子 / アルドケトース還元酵素(AKR) / 抗癌剤耐性 / メフェナム酸 / アルドース‐ケトース還元酵素（AKR） / long non-cording RNA / long non-coding RNA / 発がん / がん遺伝子 / 浸潤・転移 / 腫瘍 / Aly/REF / 唾液腺癌 / 扁平上皮癌 / 遺伝子機能評価 / 庸平上皮癌 / マイクロアレイ / cDNA / 遺伝子発現プロファイリング / 腺癌 / 遺伝子クローニング / oral cancer / microarray analysis / salivary gland tumor / squamous cell carcinoma / pleomorphic adenoma / UCA1 / LINC00256A / 共培養 / 腫瘍の浸潤・転移能 / 放射線耐性試験 / 抗癌剤耐性試験 / 抗がん剤・放射線耐性 / 抗がん剤耐性試験 / lncRNA / スーパーエンハンサー / ChIP-seq 法 / 組織特異性 / 疾患特異性 / 機能特異性 / H3K27ac / エピジェネティックな修飾 / スーパーエンハンサー(SE) / Chip-seq法 / H3K27 … More Except Principal Investigator 口腔癌 / DNA methylation / 口腔扁平上皮癌 / DNA methyltransferase / 舌癌 / 完全長cDNAライブラリー / ケラチン遺伝子 / 腫瘍拒絶抗原 / 扁平上皮癌 / ワクチン療法 / 養子免疫療法 / 免疫療法 / 臨床腫瘍学 / 低病原性ウイルス / ウイルスカプシド / 腫瘍特異的吸着 / リポソーム / 腫瘍特異性 / リボソーム / drug delivery system / シンドビスウイルス / MyoD family 遺伝子 / 脂肪幹細胞 / 筋再生 / MyoD family遺伝子 / methyltransferase / 細胞周期関連遺伝子 / 5-Aza-C / 腺癌 / CDKN2A / p16遺伝子 / APC遺伝子 / FEZ1遺伝子 / p73遺伝子 / oral squamous cell carcinoma / APC gene / p16 gene / FEZ1 gene / KAI1 gene / survivin / ノックアウトマウス / CRISPR/Cas9 / PLOD2 / LH2 / 胎生致死 / コラーゲンクロスリンク / HIF-1α / HIF1-α / 低酸素応答 / 転移モデル / GFP標識癌細胞 / Plod2 / クロスリンク解析 / ナノインデンテーション試験 / KOマウス / 扁平上皮がん / 肺扁平上皮がん / 口腔扁平上皮がん / 上皮間葉移行 / EPSTI1 / 口腔がん / 肺がん / 分子標的治療 / 頭頸部扁平上皮がん / 微小管阻害抗癌剤 / 頭頚部悪性腫瘍 / 化学療法 / 微小管阻害薬剤 / 薬剤耐性機構 / 克服薬 Less

Molecular analysis and overcoming of drug resistance to microtubule inhibitors
- Principal Investigator
  
  伏見一章
- Project Period (FY)
  2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Chiba University
CRISPRスクリーニング法を用いたセツキシマブ耐性分子機構の解明
- Principal Investigator
  
  小池一幸
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Chiba University
Development of molecular targeted therapy for pulmonary squamous cell carcinoma
- Principal Investigator
  
  瀧口裕一
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Chiba University
口腔癌悪性度を決定するスーパーエンハンサーによる系統的転写制御機構の解明Principal Investigator
- Principal Investigator
  
  椎葉正史
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Chiba University
Evaluate changes in collagen cross-linking in lysyl hydroxylase 2 knockout mice and elucidate the role of PLOD2 in cancer metastasis
- Principal Investigator
  
  Nakashima Dai
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Chiba University
Development of novel therapy based on functions of long non coding RNA in the cancer and cancer-associated cellsPrincipal Investigator
- Principal Investigator
  
  SHIIBA Masashi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  Chiba University
Regeneration of muscle by introduction of MyoD family gene into adipose-derived stem cells
- Principal Investigator
  
  SAKAMOTO Yousuke
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  Chiba University
Control mechanism elucidation of the Wnt pathway, extracellular matrix by the CD82 and the development of cancer metastasis inhibitorPrincipal Investigator
- Principal Investigator
  
  SHIIBA MASASHI
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Surgical dentistry
- Research Institution
  Chiba University
Studies of the clinical significance and the role of long non coding RNA in oral cancer.Principal Investigator
- Principal Investigator
  
  SHIIBA MASASHI
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  Chiba University
Development of enhancement chemotherapy by overcoming an anti-cancer resistant mechanism of AKR1C familyPrincipal Investigator
- Principal Investigator
  
  SHIIBA Masashi
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Surgical dentistry
- Research Institution
  Chiba University
Functional analysis of microRNA in oral carcinoma.Principal Investigator
- Principal Investigator
  
  SHIIBA Masashi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  Chiba University
Development of cancer-targeted liposome with viral proteins
- Principal Investigator
  
  UZAWA Katsuhiro
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  Chiba University
Search for oral cancer specific genes and molecular cloning using in-house cDNA microarayPrincipal Investigator
- Principal Investigator
  
  SHIBA Masashi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  Chiba University
Study on the role of DNA methyltransferases in regulation of the expression of genes associated with the control of cell cycle
- Principal Investigator
  
  BUKAWA Hiroki
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  Chiba University
腫瘍拒絶抗原分子による口腔癌の免疫療法の確立
- Principal Investigator
  
  大越基弘
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Surgical dentistry
- Research Institution
  The University of Tokyo

All 2020 2010 2009 2008

All Journal Article Presentation Patent

[Journal Article] Oncolytic activity of Sindbis virus in human oral squamous carcinoma cells2009
- Author(s)
  Saito K, Uzawa K, Kasamatsu A, Shinozuka K, Sakuma K, Yamatoji M, Shiiba M, Shino Y, Shirasawa H, Tanzawa H
- Journal Title
  
  Br J Cancer 101(4)
  
  Pages: 684-90
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390508
[Journal Article] Oncolytic virotherapy for oral squamous cell carcinoma using replication-competent viruses2009
- Author(s)
  Saito K, Shirasawa H, Isegawa N, Shiiba M, Uzawa K, Tanzawa H
- Journal Title
  
  Oral Oncology 45(12)
  
  Pages: 1021-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390508
[Patent] 腫瘍特異性を有する新型リポソーム2010
- Inventor(s)
  鵜沢一弘, 齋藤謙悟, 丹沢秀樹, 白澤浩, 山本惠司, 森部久仁一, 椎葉正史
- Industrial Property Rights Holder
  千葉大学
- Industrial Property Number
  2010-086071
- Filing Date
  2010-04-02
- Data Source
  KAKENHI-PROJECT-19390508
[Presentation] Epithelial-stromal interaction 1 (EPSTI1) in human oral and lung squamous cell carcinomas2020
- Author(s)
  Fan, M. Arai, M. Tawada, A. Chiba, T. Fukushima, R. Uzawa, K. Shiiba, M. Kato, N. Takiguchi, Y.
- Organizer
  The 79th Annual Meeting of the Japanese Cancer Asssociation
- Data Source
  KAKENHI-PROJECT-20K08561
[Presentation] Oncolytic activity of sindbis virus for oral cancer cells2008
- Author(s)
  Saito k., Shirasawa H., Shiiba M., Uzawa K., Tanzawa H
- Organizer
  3th World Congress on Advances in Oncology and 11th International Symposium on Molecular Medicine
- Place of Presentation
  Greece Krete
- Data Source
  KAKENHI-PROJECT-19390508

1. UZAWA Katsuhiro (30302558)

# of Collaborated Projects: 4 results

# of Collaborated Products: 3 results
2. TANZAWA HIDEKI (50236775)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. KASAMATSU ATSUSHI (60375730)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
4. BUKAWA Hiroki (80173558)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. SHIRASAWA Hiroshi (00216194)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
6. SAITO Kengo (70451755)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
7. SAKAMOTO Yousuke (50451745)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. OGAWARA KATSUNORI (20372360)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. Nakashima Dai (50431747)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. 小池一幸 (10618060)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. YOKOE Hidetaka (70261930)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. SEKI Naohiko (50345013)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. TAKIGUCHI Masaki (40179578)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 大越基弘 (80022888)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 森良之 (70251296)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 神津由直 (70400942)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 小池博文 (10595995)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 皆川康之 (30639787)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 瀧口裕一 (30272321)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 太和田暁之 (10596159)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 新井誠人 (30396684)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
22. 伏見一章 (90375733)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. TAKIGUCHI Yuuichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Shiiba Masashi 椎葉 正史

SHIIBA Masashi 椎葉 正史

椎葉 正史 シイバ マサシ

Research Projects

Research Products

Co-Researchers

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

口腔癌悪性度を決定するスーパーエンハンサーによる系統的転写制御機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of novel therapy based on functions of long non coding RNA in the cancer and cancer-associated cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Control mechanism elucidation of the Wnt pathway, extracellular matrix by the CD82 and the development of cancer metastasis inhibitorPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies of the clinical significance and the role of long non coding RNA in oral cancer.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of enhancement chemotherapy by overcoming an anti-cancer resistant mechanism of AKR1C familyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Functional analysis of microRNA in oral carcinoma.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Search for oral cancer specific genes and molecular cloning using in-house cDNA microarayPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Shiiba Masashi 椎葉正史

SHIIBA Masashi 椎葉正史

椎葉正史シイバマサシ