MIZUKAMI Horoaki 水上浩明

… Alternative Names

水上裕明ミズカミヒロアキ

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Researcher Number	20311938
Other IDs
Affiliation (Current)	2025: 自治医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2014 – 2024: 自治医科大学, 医学部, 教授 2011 – 2013: 自治医科大学, 医学部, 准教授 2003 – 2010: Jichi Med.Sch., Faculty of Medicine, Assistant Professor, 医学部, 講師 2009: 医学部, 講師 2007: Jichi Medical School, Faculty of medicine, Assistant professor 2005 – 2006: 東京大学, 医学部附属病院, 講師 1999 – 2003: 自治医科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Hematology / Hematology Except Principal Investigator Hematology / Otorhinolaryngology / Biological Sciences / Basic Section 56050:Otorhinolaryngology-related / Basic Section 56010:Neurosurgery-related / Surgical dentistry / Basic Section 55020:Digestive surgery-related / Basic Section 54030:Infectious disease medicine-related / Hematology / 医薬分子機能学 / Embryonic/Neonatal medicine
Keywords	Principal Investigator AAVベクター / 遺伝子治療 / 血清型 / adipose tissue / AAV Vectors / 凝固第IX因子 / エリスロポエチン / 凝固第VIII因子 / 血友病A / 血友病 … More / 免疫応答 / 組織特異性 / polycythemia / tissue specificity / erythropoietin / pluronic / gene therapy / hemophilia / 摘出手術 / 遺伝子導入 / 添加剤 / 多血症 / プルロニック / 脂肪細胞 / immune response / coagulation factor VIII / coagulation factor IX / hemophilia A / hemophilia B / serotypes / 抗体 / 脂肪組織 / 血友病B / liver / skeletal muscle / serotype / promoters / Coagnlation Factor VIII / Hemophilia A / AAV vector / adeno-associated virus / 肝臓 / 骨格筋 / プロモーター / アデノ随伴ウイルス / AAV / ベクター / 免疫学 / バイオテクノロジー / ウイルス / 遺伝子 / トランスジェニックスマウス / 中和抗体 / トランスジェニックマウス / AAV ベクター … More Except Principal Investigator 遺伝子治療 / 遺伝子導入 / 頭頸部癌 / 癌抑制遺伝子 / AAVベクター / ITR / Rep / gene therapy / アデノ随伴ウイルス / DNAメチル化 / bone destruction / AAV vector / 分子標的治療 / ウイルスベクター / 組織特異性 / G蛋白共役受容体 / 膠芽腫 / メチル化 / Msx1 / gene targeting / antisense / iNOS / db / NOD / Gene therapy / TVI法 / AAVS1領域 / 造血幹細胞 / AAV / バキュロウイルス / がん遺伝子治療 / 血管新生 / 胃癌 / エクソソーム / 大網乳斑 / microRNA / がん微小環境 / 腹膜播種 / 熱帯熱マラリア / ワクシニアウイルス / 伝播阻止 / 感染防御 / ワクチン / 三日熱マラリア / 脱メチル化 / TET2遺伝子 / 甲状腺未分化癌 / ソマトスタチン受容体 / 悪性神経膠腫 / 脳腫瘍 / エピジェネティックス / 唾液腺導管癌 / platelet-activating factor / osteoclast / lipid mediator / 骨破壊病変遺伝子治療 / 非病原性ベクター / 血小板活性化因子 / 破骨細胞 / 骨破壊性病変 / 脂質メディエータ / Stem cell / Hematopoietic system / Skeletal muscle / Plasticity / Transdifferentiation / Dedifferentiation / AVVベクター / 幹細胞 / 造血系 / 骨格筋 / 可塑性 / 分化転換 / 脱分化 / degrading enzyme / viral vector / gene transfer / adeno-associated virus / neprilysin / amyloid-β peptide / Alzheimer's Disease / 分解酵素 / ネプリライシン / アミロイドβペプチド / アルツハイマー病 / adaptor molecule / adenoviral vector / targeted vector integration / protein-supplement gene therapy / tissue specificity / 血清型 / 免疫反応 / 凝固因子 / エリスロポエチン / アダプター分子 / アデノウイルスベクター / 染色体部位特異的遺伝子組込み / 蛋白質補充遺伝子療法 / db mice / SCID mice / Adipocyte / Hematopoietic stem cell / SIV virus vector / Factor VIII / Hemophilia A / 肝細胞 / dbマウス / SCIDマウス / 脂肪細胞 / SIVウイルスベクター / 血液凝固第VIII因子 / 血友病 / TVI method / AAVS1 locus / packaging cell line / Gene transfer / パッケージング細胞株 / selective amplifier gene / chronic granulomatous disease / hematopoietic stem cells / レトロウイルスベクター / 選択的増幅遺伝子 / 慢性肉芽腫症 / 分子標的治療薬 / アポトーシス / GPCR / アデノ随伴ウイルスベクター / 治療 / 頭頚部癌 / GALR2 / Ｇ蛋白共役受容体 / GALR２ / GALR1 / トランスレーショナルリサーチ / 新生児 / 先天代謝異常 / ウィルス / 担癌ヌードマウス / ヒストン脱アセチル化酵素阻害剤 / リンパ行性転移抑制 / 抗腫瘍血管遺伝子療法 / VEGF-C / sFlt-4 / sFlt-1 / リンパ管新生 / バイオテクノロジー / 癌 / ウイルス / 遺伝子 / NK4 / IL-10 / 可溶型Flt-1 / 卵巣癌 Less

Development of novel therapy targeting microRNA for peritoneal dissemination and elucidation of its immunological mechanism
- Principal Investigator
  
  北山丈二
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Jichi Medical University
Development of multidrug combination molecular targeted therapeutics based on G protein-coupled receptor interactions in glioblastoma
- Principal Investigator
  
  草鹿元
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Jichi Medical University
甲状腺未分化癌に対する脱メチル化遺伝子治療の基礎研究
- Principal Investigator
  
  佐々木徹
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Jichi Medical University
Development of Plasmodium vivax vaccine effective both for protection and transmission-blockade
- Principal Investigator
  
  吉田栄人
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  Kanazawa University
Multi-targeted demethylation gene therapy for glioblastoma using the TET2 gene.
- Principal Investigator
  
  Kusaka Gen
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Jichi Medical University
頭頸部癌に対するソマトスタチン受容体の遺伝子導入と新規分子標的治療
- Principal Investigator
  
  金澤丈治
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Jichi Medical University
Development of novel gene therapy for head and neck cancer applying demethylation mechanism
- Principal Investigator
  
  Kanazawa Takeharu
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Jichi Medical University
Molecular Targeted Therapy Utilizing Galanin receptor type 2 signaling for Head and Neck Cancer
- Principal Investigator
  
  Kanazawa Takeharu
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Jichi Medical University
Development of gene therapy approaches towards hemophilia APrincipal Investigator
- Principal Investigator
  
  Mizukami Hiroaki
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Jichi Medical University
Preclinical study for Head and Neck Cancer using rAAV-GALR2
- Principal Investigator
  
  KANAZAWA Takeharu
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Jichi Medical University
Gene Therapy for Head and Neck Cancer using Adeno-Associated Virus Vector Harboring Galanin Receptor type1
- Principal Investigator
  
  KANAZAWA Hiromi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Jichi Medical University
Improvement of neutralizing antibody assay against AAV vectors and application to hemophilia gene therapyPrincipal Investigator
- Principal Investigator
  
  MIZUKAMI Hiroaki
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Jichi Medical University
Tissue specificity and utility of AAV vectors in hemophilia gene therapyPrincipal Investigator
- Principal Investigator
  
  MIZUKAMI Hiroaki
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Jichi Medical University
Development of AAV (adeno-associated virus) vectors and their application to cancer therapy
- Principal Investigator
  
  OZAWA Keiya
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Jichi Medical University
新生児期遺伝子治療におけるアデノ随伴ウイルスベクターの体内動態と治療効果
- Principal Investigator
  
  久米晃啓
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Embryonic/Neonatal medicine
- Research Institution
  Jichi Medical University
Gene therapy targeting lipid mediators for prevention of bone destruction
- Principal Investigator
  
  HIKIJI Hisako
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  The University of Tokyo
Optimization of gene transfer conditions to adipose tissue and application toward hemophiliaPrincipal Investigator
- Principal Investigator
  
  MIZUKAMI Hiroaki
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Jichi Medical University
DEDIFFERENTIATION OF NON-HEMATOPOIETIC TISSUE BY GENETIC MANIPULATION AND ITS ACQUISITION OF PLASTICITY AND HEMATOPOIETIC TRANSDIFFERENTIATION
- Principal Investigator
  
  OZAWA Keiya
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  JICHI MEDICAL UNIVERSITY
アデノ随伴ウイルス(AAV)ベクターの開発とその癌遺伝子治療への応用
- Principal Investigator
  
  小澤敬也 (小沢敬也)
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Jichi Medical University
Optimization of gene therapy approaches for hemophiliaPrincipal Investigator
- Principal Investigator
  
  MIZUKAMI Hiroaki
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Jichi Medical School
AAV-mediated bone gene therapy targeting nitric oxide synthase
- Principal Investigator
  
  HIKIJI Hisako
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  The University of Tokyo
Development of basic technologies for gene therapy using adeno-associated virus (AAV)
- Principal Investigator
  
  OZAWA Kaiya
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  Jichi Medical School
Gene therapy for Alzheimer's disease by viral vector-mediated neprilysin, an Aβ-degrading enzyme, gene transfer
- Principal Investigator
  
  IWATA Nobuhisa
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  医薬分子機能学
- Research Institution
  The Institute of Physical and Chemical Research
Gene therapy for hemophilia A with simian immunodeficiency virus agmTYO1-based vectors carrying human factor VIII gene.
- Principal Investigator
  
  MADOIWA Seiji
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Jichi Medical School
AAVベクターによる抗腫瘍血管療法と新規アデノ-AAVハイブリッドベクターの開発
- Principal Investigator
  
  KUME Akihiro
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Jichi Medical University
Development of the gene therapy technologies using adeno-associated virus (AAV)
- Principal Investigator
  
  OZAWA Keiya
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  Jichi Medical School
Fundamental researches toward gene therapy of Hemophilia A utilizing adeno-associated virus vectorsPrincipal Investigator
- Principal Investigator
  
  MIZUKAMI Hiroaki
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Jichi Medical School
Gene transfer into hematopoietic stem cells and gene therapy for chronic granulomatous disease
- Principal Investigator
  
  KUME Akihiro
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  Jichi Medical School

[Book] J Thromb Haemost2015
- Author(s)
  Ohmori T, Mizukami H, Ozawa K, Sakata Y. Nishimura S.
- Total Pages
  10
- Publisher
  Wiley
- Data Source
  KAKENHI-PROJECT-25461460
[Book] Gene Therapy and Cell Therapy through the Liver: Current Aspects and Future Prospects2015
- Author(s)
  Mizukami H, et al.
- Total Pages
  115
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-25461460
[Book] Gene Therapy and Cell Therapy through the Liver: Current Aspects and Future Prospects (Terai S. and Suda T. Eds)2015
- Author(s)
  Mizukami H, Mimuro J, Ohmori T, Sakata Y, Ozawa K.
- Total Pages
  15
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-25461460
[Book] 動物の事典2015
- Author(s)
  水上　浩明
- Publisher
  朝倉書店
- Data Source
  KAKENHI-PROJECT-25461460
[Book] 遺伝子・DNA利用の製品研究開発における規制・倫理対応と解析，操作技術のトラブル対策2014
- Author(s)
  水上浩明
- Publisher
  技術情報協会
- Data Source
  KAKENHI-PROJECT-25461460
[Book] 血友病の遺伝子治療血液フロンティア2012
- Author(s)
  水上浩明
- Publisher
  医薬ジャーナル社
- Data Source
  KAKENHI-PROJECT-21591248
[Book] 筋疾患に対する遺伝子治療生体の科学2011
- Author(s)
  水上浩明
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-21591248
[Book] Gene Therapy for Diabetic Retinopathy in Animal Models and Humans. In, The Open Diabetes Journal? Novel rat model of diabetes, SDT rat and SDT fatty rat.(ed. By Kahehashi, A.)2011
- Author(s)
  Mizukami, H., Urabe, M., Kume, A. Ozawa, K.
- Data Source
  KAKENHI-PROJECT-21591248
[Book] 網膜疾患に対する遺伝子治療の現状と展望2011
- Author(s)
  水上浩明
- Publisher
  医歯薬出版
- Data Source
  KAKENHI-PROJECT-21591248
[Book] 遺伝子導入とベクターBIO Clinica2011
- Author(s)
  水上浩明
- Publisher
  北隆館
- Data Source
  KAKENHI-PROJECT-21591248
[Book] Gene Therapy for Diabetic Retinopathy in Animal Models and Humans. In, The Open Diabetes Journal-Novel rat model of diabetes, SDT rat and SDT fatty rat.(ed.By Kahehashi, A.)2011
- Author(s)
  Mizukami H, et al
- Total Pages
  122
- Publisher
  Bentham
- Data Source
  KAKENHI-PROJECT-21591248
[Book] 糖尿病学-基礎と臨床2007
- Author(s)
  水上浩明(分担執筆)
- Total Pages
  1200
- Publisher
  西村書店
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591007
[Book] 『糖尿病学-基礎と臨床』2007
- Author(s)
  水上浩明(分担執筆)
- Total Pages
  1200
- Publisher
  西村書店
- Data Source
  KAKENHI-PROJECT-19591134
[Journal Article] Adeno-associated virus-based malaria booster vaccine following attenuated replication-competent vaccinia virus LC16m8Δ priming2023
- Author(s)
  Hasyim Ammar A.、Iyori Mitsuhiro、Mizuno Tetsushi、Abe Yu-ichi、Yamagoshi Iroha、Yusuf Yenni、Syafira Intan、Shahnaij Mohammad、Sakamoto Akihiko、Yamamoto Yutaro、Mizukami Hiroaki、Shida Hisatoshi、Yoshida Shigeto
- Journal Title
  
  Parasitology International
  
  Volume: 92 Pages: 102652-102652
- DOI
  10.1016/j.parint.2022.102652
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06545, KAKENHI-PROJECT-21K06559, KAKENHI-PROJECT-22K19374, KAKENHI-PROJECT-23K24375
[Journal Article] Sterile protection and transmission blockade by a multistage anti-malarial vaccine in the pre-clinical study2022
- Author(s)
  Iyori Mitsuhiro、Blagborough Andrew M.、Mizuno Tetsushi、Abe Yu-ichi、Nagaoka Mio、Hori Naoto、Yamagoshi Iroha、Da Dari F.、Gregory William F.、Hasyim Ammar A.、Yamamoto Yutaro、Sakamoto Akihiko、Yoshida Kunitaka、Mizukami Hiroaki、Shida Hisatoshi、Yoshida Shigeto
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 13 Pages: 1-13
- DOI
  10.3389/fimmu.2022.1005476
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06545, KAKENHI-PROJECT-21K06559, KAKENHI-PROJECT-22K19374, KAKENHI-PROJECT-23K24375
[Journal Article] The Tol2 transposon system mediates the genetic engineering of T-cells with CD19-specific chimeric antigen receptors for B-cell malignancies.2015
- Author(s)
  Tsukahara, T., Iwase, N., Kawakami, K., Iwasaki, M., Yamamoto, C., Ohmine, K.,Uchibori, R., Teruya, T., Ido, H., Yasushi, S., Urabe, M., Mizukami, H., Kume, A., Nakamura, M., Brentjens, R., Ozawa, K.
- Journal Title
  
  Gene Ther
  
  Volume: 22 Pages: 209-15
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461460
[Journal Article] The angiogenesis regulator vasohibin-1 inhibits ovarian cancer growth and peritoneal dissemination and prolongs host survival.2015
- Author(s)
  Takahashi, Y., Saga, Y., Koyanagi, T., Takei, Y., Machida, S., Taneichi, A., Mizukami, H., Sato, Y., Matsubara, S., Fujiwara, H.
- Journal Title
  
  Int J Oncol
  
  Volume: 47 Pages: 2057-63
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461460
[Journal Article] Long-term two-photon calcium imaging of neuronal populations with subcellular resolution in adult non-human primates2015
- Author(s)
  Sadakane, O., Masamizu, Y., Watakabe, A., Terada, S., Ohtsuka, M., Takaji, M., Mizukami, H., Ozawa, K., Kawasaki, H., Matsuzaki, M., Yamamori, T.
- Journal Title
  
  Cell Reports
  
  Volume: 13 Pages: 1989-99
- NAID
  120005829368
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461460
[Journal Article] Comparative analyses of adeno-associated viral vector serotypes 1, 2, 5, 8 and 9 in marmoset, mouse and macaque cerebral cortex.2015
- Author(s)
  Watakabe, A., Ohtsuka, M., Kinoshita, M., Takaji, M., Isa, K., Mizukami, H., Ozawa, K., Isa, T., Yamamori, T.
- Journal Title
  
  Neurosci Res
  
  Volume: 93 Pages: 144-57
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461460
[Journal Article] Novel anti-tumor mechanism of galanin receptor type 2 in head and neck squamous cell carcinoma cells.2014
- Author(s)
  Uehara T, Kanazawa T, Mizukami H, Uchibori R, Tsukahara T, Urabe M, Kume A, Misawa K, Carey TE, Suzuki M, Ichimura K, Ozawa K.
- Journal Title
  
  Cancer Sci.
  
  Volume: 105 Pages: 72-80
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592539
[Journal Article] Novel anti-tumor mechanism of galanin receptor type 2 in head and neck squamous cell carcinoma cells2014
- Author(s)
  Uehara T, Kanazawa T, Mizukami H, Uchibori R, Tsukahara T, Urabe M, Kume A, Misawa K, Carey T, Suzuki M, Ichimura K, Ozawa K
- Journal Title
  
  Cancer Science
  
  Volume: 105 Issue: 1 Pages: 72-80
- DOI
  10.1111/cas.12315
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23591548, KAKENHI-PROJECT-24390247, KAKENHI-PROJECT-24592594, KAKENHI-PROJECT-25430155, KAKENHI-PROJECT-25461460
[Journal Article] Novel anti-tumor mechanism of galanin receptor type 2 in head and neck squamous cell carcinoma cells2014
- Author(s)
  Uehara T, Kanazawa T, Mizukami H, Uchibori R, Tsukahara T, Urabe M, Kume A, Misawa K, Carey TE, Suzuki M, Ichimura K, Ozawa K
- Journal Title
  
  Cancer Sci
  
  Volume: 105 Pages: 72-80
- Data Source
  KAKENHI-PROJECT-23592539
[Journal Article] The prevalence of neutralizing antibodies against adeno-associated virus capsids is reduced in young Japanese individuals.2014
- Author(s)
  Mimuro J, Mizukami H, Shima M, Matsushita T, Taki M, Muto S, Higasa S, Sakai M, Ohmori T, Madoiwa S, Ozawa K, and Sakata Y.
- Journal Title
  
  J. Med. Virol.
  
  Volume: 86 Issue: 11 Pages: 1990-1997
- DOI
  10.1002/jmv.23818
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24390247, KAKENHI-PROJECT-24591430, KAKENHI-PROJECT-25461460
[Journal Article] Interleukin-10 expression induced by adeno-associated virus vector suppresses proteinuria in Zucker obese rats2012
- Author(s)
  Ogura M, Urabe M, Akimoto T, Onishi A, Ito C, Ito T, Tsukahara T, Mizukami H, Kume A, Muto S, Kusano E, Ozawa K
- Journal Title
  
  Gene Ther
  
  Volume: 19 Pages: 476-82
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591248
[Journal Article] Recovery of neurogenic amines in phenylketonuria mice following liver-targeted gene therapy2012
- Author(s)
  Yagi, H., Sanechika, S., Ichinose, H., Sumi-Ichinose, C., Mizukami, H., Urabe, M., Ozawa, K., Kume, A.
- Journal Title
  
  Neuroreport
  
  Volume: 23 Pages: 30-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591248
[Journal Article] Development of a mouse model for lymph node metastasis with endometrial cancer2011
- Author(s)
  Takahashi, K., Saga, Y., Mizukami, H., Takei, Y., Urabe, M., Kume, A., Suzuki, M., Ozawa, K.
- Journal Title
  
  Cancer Sci
  
  Volume: 102 Pages: 2272-7
- NAID
  10030246395
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591248
[Journal Article] Complete restoration of phenylalanine oxidation in phenylketonuria mouse by a self-complementary adeno-associated virus vector2011
- Author(s)
  Yagi, H., Ogura, T., Mizukami, H., Urabe, M., Hamada, H., Yoshikawa, H., Ozawa, K., Kume, A.
- Journal Title
  
  J Gene Med
  
  Volume: 13 Pages: 114-22
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591248
[Journal Article] A phase I study of aromatic L-amino acid decarboxylase gene therapy for Parkinson's disease2010
- Author(s)
  Muramatsu, S., Fujimoto, K., Kato, S., Mizukami, H., Asari, S., Ikeguchi, K., Kawakami, T., Urabe, M., Kume, A., Sato, T., Watanabe, E., Ozawa, K., Nakano, I.
- Journal Title
  
  Mol Ther
  
  Volume: 18 Pages: 1731-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591248
[Journal Article] Mutant Macaque Factor IX T262A : A Tool for Hemophilia B Gene Therapy Studies in Macaques2010
- Author(s)
  Ishiwata, A., Mimuro, J., Mizukami, H., Kashiwakura, Y., Yasumoto, A., Sakata, A., Ohmori, T., Madoiwa, S., Ono, F., Shima, M., Yoshioka, A., Ozawa, K., Sakata, Y.
- Journal Title
  
  Thromb Res
  
  Volume: 125 Pages: 533-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591248
[Journal Article] Retroviral vector-producing mesenchymal stem cells for targeted suicide cancer gene therapy.2009
- Author(s)
  Uchibori, R., Okada, T., Ito, T., Urabe, M., Mizukami, H., Kume, A., Ozawa, K.
- Journal Title
  
  J. Gene Med. 11
  
  Pages: 373-381
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016067
[Journal Article] Systemic delivery of IL-10 by an AAV vector prevents vascular remodeling and end-organ damage in stroke-prone spontaneously hypertensive rat.2009
- Author(s)
  Nomoto, T., Okada, T., Shimazaki, K., Yoshioka, T., Nonaka-Sarukawa, M., Ito, T., Takeuchi, K., Katsura, K., Mizukami, H., Kume, A., Ookawara, S., Ikeda, U., Katayama, Y., Ozawa, K.
- Journal Title
  
  Gene Ther 16
  
  Pages: 383-91
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591134
[Journal Article] Generation of adeno-associated virus vector enabling functional expression of oxytocin receptor and fluorescence marker genes using the human eIF4G internal ribosome entry site element.2009
- Author(s)
  Sato, K., Date, S., Aoyagi, Y., Kasahara, Y., Nawa, A., Mizukami, H., Hidema, S., Ozawa, K., Nishimori, K.
- Journal Title
  
  Biosci. Biotechnol. Biochem. 73(9)
  
  Pages: 2145-2148
- NAID
  10027546295
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016067
[Journal Article] A convenient enzyme-linked immunosorbent assay for rapid screening of anti-adeno-associated virus neutralizing antibodies.2009
- Author(s)
  Ito, T., Yamamoto, S., Hayashi, T., Kodera, M., Mizukami, H., Ozawa, K., Muramatsu, S.
- Journal Title
  
  Ann. Clin. Biochem. 46(Pt6)
  
  Pages: 508-510
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016067
[Journal Article] Retroviral vector-producing mesenchymal stem cells for targeted suicide cancer gene therapy2009
- Author(s)
  Uchibori, R., Okada, T., Ito, T., Urabe, M., Mizukami, H., Kume, A., Ozawa, K.
- Journal Title
  
  J Gene Med
  
  Volume: 11 Pages: 373-81
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591248
[Journal Article] Liver-restricted expression of the canine factor VIII gene facilitates prevention of inhibitor formation in factor VIII-deficient mice2009
- Author(s)
  Ishiwata, A., Mimuro, J., Mizukami, H., Kashiwakura, Y., Takano, K., Ohmori, T., Madoiwa, S., Ozawa, K., Sakata, Y.
- Journal Title
  
  J Gene Med
  
  Volume: 11 Pages: 1020-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591248
[Journal Article] Cetuximab inhibits growth, peritoneal dissemination, and lymph node and lung metastasis of endometrial cancer, and prolongs host survival2009
- Author(s)
  Takahashi, K., Saga, Y., Mizukami, H., Takei, Y., Machida, S., Fujiwara, H., Ozawa, K., Suzuki, M.
- Journal Title
  
  Int J Oncol
  
  Volume: 35 Pages: 725-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591248
[Journal Article] Adeno-associated virus vector-mediated systemic interleukin-10 expression ameliorates hypertensive organ damage in Dahl salt-sensitive rats.2008
- Author(s)
  Nonaka-Sarukawa, M., Okada, T., Ito, T., Yamamoto, K., Yoshioka, T., Nomoto, T., Hojo, Y., Shimpo, M., Urabe, M., Mizukami, H., Kume, A., Ikeda, U., Shimada, K., Ozawa, K.
- Journal Title
  
  J Gene Med 10
  
  Pages: 368-74
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591134
[Journal Article] Protection Against Aminoglycoside-induced Ototoxicity by Regulated AAV Vector-mediated GDNF Gene Transfer Into the Cochlea.2008
- Author(s)
  Liu, Y., Okada, T., Shimazaki, K., Sheykholeslami, K., Nomoto, T., Muramatsu, SI., Mizukami, H., Kume, A., Xiao, S., Ichimura, K., Ozawa, K.
- Journal Title
  
  Mol Ther 16
  
  Pages: 474-80
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591134
[Journal Article] Protection against aminoglycoside-induced ototoxicity by regulated AAV vector-mediated GDNF gene transfer into the cochlea.2008
- Author(s)
  Liu, Y., Okada, T., Shimazaki, K., Sheykholeslami, K., Nomoto, T., Muramatsu, S., Mizukami, H., Kume, A., Xiao, S., Ichimura, K., Ozawa, K.
- Journal Title
  
  Mol. Ther. 16(3)
  
  Pages: 474-480
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016067
[Journal Article] Adeno-associated virus vector-mediated production of hepatocyte growth factor attenuates liver fibrosis in mice.2008
- Author(s)
  Suzumura, K., Hirano, T., Son, G., Iimuro, Y., Mizukami, H., Ozawa, K., Fujimoto, J.
- Journal Title
  
  Hepatol Int 2
  
  Pages: 80-88
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591134
[Journal Article] Overexpression of PTEN in ovarian cancer cells suppresses i. p. dissemination and extends survival in mice.2008
- Author(s)
  Takei, Y., Saga, Y., Mizukami, H., Takayama, T., Ohwada, M., Ozawa, K., Suzuki, M.
- Journal Title
  
  Mol. Cancer. Ther. 7(3)
  
  Pages: 704-711
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016067
[Journal Article] Adeno-associated virus vector-mediated systemic interleukin-10 expression ameliorates hypertensive organ damage in Dahl salt-sensitive rats.2008
- Author(s)
  Nonaka-Sarukawa, M., Okada, T., Ito, T., Yamamoto, K., Yoshioka, T., Nomoto, T., Hojo, Y., Shimpo, M., Urabe, M., Mizukami, H., Kume, A., Ikeda, U., Shimada, K., Ozawa, K.
- Journal Title
  
  J Gene Med. 10(4)
  
  Pages: 368-374
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016067
[Journal Article] Overexpression of PTEN in ovarian cancer cells suppresses i.p. dissemination and extends survival in mice.2008
- Author(s)
  Takei, Y., Saga, Y., Mizukami, H., Takayama, T., Ohwada, M., Ozawa, K., Suzuki, M.
- Journal Title
  
  Mol Cancer Ther 7
  
  Pages: 704-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591134
[Journal Article] Suppression of ovarian cancer by muscle-mediated expression of soluble VEGFR-1/Flt-1 using adeno-associated virus serotype 1-derived vector.2007
- Author(s)
  Takei, Y., Mizukami, H., Saga, Y., Yoshimura, I., Hasumi, Y., Takayama, T., Kohno, T., Matsushita, T., Okada, T., Kume, A., Suzuki, M., Ozawa, K.
- Journal Title
  
  Int J Cancer 120
  
  Pages: 278-84
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591007
[Journal Article] Prevention of diabetic retinopathy by intraocular soluble Flt-1 gene transfer in a spontaneously diabetic rat model.2007
- Author(s)
  Ideno, J., Mizukami, H., Kakehashi, A., Saito, Y., Okada, T., Urabe, M., Kume, A., Kuroki, M., Kawakami, M., Ishibashi, S., Ozawa, K.
- Journal Title
  
  Int. J. Mol. Med. 19
  
  Pages: 75-79
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016067
[Journal Article] Adenoassociated virus-mediated prostacyclin synthase expression prevents pulmonary arterial hypertension in rats.2007
- Author(s)
  Ito, T., Okada, T., Mimuro, J., Miyashita, H., Uchibori, R., Urabe, M., Mizukami, H., Kume, A., Takahashi, M., Ikeda, U., Sakata, Y., Shimada, K., Ozawa, K.
- Journal Title
  
  Hypertension 50
  
  Pages: 531-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591134
[Journal Article] Tendon healing in vitro : Adeno-associated virus-2 effectively transduces intrasynovial tenocytes with persistent expression of the transgene, but other serotypes do not.2007
- Author(s)
  Wang, X.T., Liu, P.Y., Tang, J.B., Mizukami, H., Xin, KQ., Ozawa, K., Ushijima, H.
- Journal Title
  
  Plast Reconstr Surg 119
  
  Pages: 227-34
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591007
[Journal Article] Adeno-associated virus-mediated prostacyclin synthase expression prevents pulmonary arterial hypertension in rats.2007
- Author(s)
  Ito, T., Okada, T., Mimuro, J., Miyashita, H., Uchibori, R., Urabe, M., Mizukami, H., Kume, A., Takahashi, M., Ikeda, U., Sakata, Y., Shimada, K., Ozawa, K.
- Journal Title
  
  Hypertension 50
  
  Pages: 531-536
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016067
[Journal Article] Suppression of ovarian cancer by muscle-mediated expression of soluble VEGFR-1/Flt-1 using adeno-associated virus serotype 1-derived vector.2007
- Author(s)
  Takei, Y., Mizukami, H., Saga, Y., Yoshimura, I., Hasumi, Y., Takayama, T., Kohno, T., Matsushita, T., Okada, T., Kume, A., Suzuki, M., Ozawa, K.
- Journal Title
  
  Int J Cancer 120
  
  Pages: 27-84
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591134
[Journal Article] Prevention of diabetic retinopathy by intraocular soluble flt-1 gene transfer in a spontaneously diabetic rat model.2007
- Author(s)
  Ideno, J., Mizukami, H., Kakehashi, A., Saito, Y., Okada, T., Urabe, M., Kume, A., Kuroki, M., Kawakami, M., Ishibashi, S., and Ozawa, K.
- Journal Title
  
  Int J Mol Med 19
  
  Pages: 75-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591134
[Journal Article] Tendon healing in vitro: Adeno-associated virus-2 effectively transduces intrasynovial tenocytes with persistent expression of the transgene, but other serotypes do not.2007
- Author(s)
  Wang, X.T., Liu, P.Y., Tang, J.B., Mizukami, H., Xin, KQ., Ozawa, K., Ushijima, H.
- Journal Title
  
  Plast Reconstr Surg 119
  
  Pages: 227-34
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591134
[Journal Article] Interleukin-10 expression mediated by an adeno-associated virus vector prevents monocrotaline-induced pulmonary arterial hypertension in rats.2007
- Author(s)
  Ito, T., Okada, T., Miyashita, H., Nomoto, T., Nonaka-Sarukawa, M., Uchibori, R., Maeda, Y., Urabe, M., Mizukami, H., Kume, A., Takahashi, M., Ikeda, U., Shimada, K., Ozawa, K.
- Journal Title
  
  Circ Res 101
  
  Pages: 734-41
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591134
[Journal Article] Prevention of diabetic retinopathy by intraocular soluble flt-1 gene transfer in a spontaneously diabetic rat model.2007
- Author(s)
  Ideno, J., Mizukami, H., Kakehashi, A., Saito, Y., Okada, T., Urabe, M., Kume, A., Kuroki, M., Kawakami, M., Ishibashi, S., Ozawa, K.
- Journal Title
  
  Int J Mol Med 19
  
  Pages: 75-9
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591007
[Journal Article] Interleukin-10 expression mediated by an adeno-associated virus vector prevents monocrotaline-induced pulmonary arterial hypertension in rats.2007
- Author(s)
  Ito, T., Okada, T., Miyashita, H., Nomoto, T., Nonaka-Sarukawa, M., Uchibori, R., Maeda, Y., Urabe, M., Mizukami, H., Kume, A., Takahashi, M., Ikeda, U., Shimada, K., Ozawa, K.
- Journal Title
  
  Circ. Res. 101
  
  Pages: 734-741
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016067
[Journal Article] Adipose tissue as a novel target for in vivo gene transfer by using adeno-associated virus vectors.2006
- Author(s)
  Mizukami, H., Mimuro, J., Ogura, T., Okada, T., Urabe, M., Kume, A., Sakata, Y., Ozawa, K.
- Journal Title
  
  Hum Gene Ther 17
  
  Pages: 921-8
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591007
[Journal Article] Utility of intraperitoneal administration as a route of AAV serotype 5 vector-mediated neonatal gene transfer.2006
- Author(s)
  Ogura, T., Mizukami, H., Mimuro, J., Madoiwa, S., Okada, T., Matsushita, T., Urabe, M., Kume, A., Hamada, H., Yoshikawa, H., Sakata, Y., Ozawa, K.
- Journal Title
  
  Gene Med. 8
  
  Pages: 990-997
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016067
[Journal Article] Adipose tissue as a novel target for in vivo gene transfer by using adeno-associated virus vectors.2006
- Author(s)
  Mizukami H, et al.
- Journal Title
  
  Hum Gene Ther 17・9
  
  Pages: 921-8
- Data Source
  KAKENHI-PROJECT-17591007
[Journal Article] A histone deacetylase inhibitor enhances recombinant adeno-associated virus-mediated gene expression in tumor cells.2006
- Author(s)
  Okada, T., Uchibori, R., Iwata-Okada, M., Takahashi, M., Nomoto, T., Nonaka-Sarukawa, M., Ito, T., Liu, Y., Mizukami, H., Kume, A., Kobayashi, E., Ozawa, K.
- Journal Title
  
  Mol. Ther. 13
  
  Pages: 738-746
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016067
[Journal Article] Suppression of ovarian cancer by muscle-mediated expression of soluble VEGFR-1/Flt-1 using adeno-associated virus serotype 1-derived vector.2006
- Author(s)
  Takei, Y., Mizukami, H., Saga, Y., Yoshimura, I., Hasumi, Y., Takayama, T., Kohno, T., Matsushita, T., Okada, T., Kume, A., Suzuki, M., Ozawa, K.
- Journal Title
  
  Int. J. Cancer 120
  
  Pages: 278-284
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016067
[Journal Article] Scalable generation of high-titer recombinant adeno-associated virus type 5 in insect cells.2006
- Author(s)
  Urabe, M., Nakakura, T., Xin, KQ., Obara, Y., Mizukami, H., Kume, A., Kotin, RM., Ozawa, K.
- Journal Title
  
  J Virol 80
  
  Pages: 1874-85
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591007
[Journal Article] Utility of intraperitoneal administration as a route of AAV serotype 5 vector-mediated neonatal gene transfer.2006
- Author(s)
  Ogura, T., Mizukami, H., Mimuro, J., Madoiwa, S., Okada, T., Matsushita, T., Urabe, M., Kume, A., Hamada, H., Yoshikawa, H., Sakata, Y., Ozawa, K.
- Journal Title
  
  J Gene Med 8
  
  Pages: 990-7
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591007
[Journal Article] Removal of empty capsids from type 1 adeno-associated virus vector stocks by anion-exchange chromatography potentiates transgene expression.2006
- Author(s)
  Urabe, M., Xin, K.Q., Obara, Y., Nakakura, T., Mizukami, H., Kume, A., Okuda, K., Ozawa, K.
- Journal Title
  
  Mol. Ther. 13
  
  Pages: 823-828
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016067
[Journal Article] Scalable generation of high-titer recombinant adeno-associated virus type 5 in insect cells.2006
- Author(s)
  Urabe M, Nakakura T, Xin KQ, Obara Y, Mizukami H, Kume A, Kotin RM, Ozawa K.
- Journal Title
  
  J.Virol. 80
  
  Pages: 1874-1885
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390281
[Journal Article] Adipose tissue as a novel target for in vivo gene transfer by using adeno-associated virus vectors.2006
- Author(s)
  Mizukami H, et al.
- Journal Title
  
  Hum Gene Ther 17巻
  
  Pages: 921-928
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591007
[Journal Article] Adipose tissue as a novel target for in vivo gene transfer by adeno-associated viral vectors.2006
- Author(s)
  Mizukami, H.
- Journal Title
  
  Hum.Gene Ther. 17・9
  
  Pages: 921-928
- Data Source
  KAKENHI-PROJECT-17016067
[Journal Article] A histone deacetylase inhibitor enhances recombinant adeno-associated virus-mediated gene expression in tumor cells.2006
- Author(s)
  Okada, T., Uchibori, R., Iwata-Okada, M., Takahashi, M., Nomoto, T., Nonaka-Sarukawa, M., Ito, T., Liu, Y., Mizukami, H., Kume, A., Kobayashi, E., Ozawa, K.
- Journal Title
  
  Mol.Ther. 13
  
  Pages: 738-746
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390281
[Journal Article] Phenotype correction of hemophilia A mice with adeno-associated virus vectors carrying the B domain-deleted canine factor VIII gene.2006
- Author(s)
  Ishiwata, A., Mimuro, J., Kashiwakura, Y., Niimura, M., Takano, K., Ohmori, T., Madoiwa, S., Mizukami, H., Okada, T., Naka, H., Yoshioka, A., Ozawa, K., Sakata, Y.
- Journal Title
  
  Thromb Res 118
  
  Pages: 627-35
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591007
[Journal Article] Removal of empty capsids from type 1 adeno-associated virus vector stocks by anion-exchange chromatography potentiates transgene expression.2006
- Author(s)
  Urabe, M., Xin, KQ., Obara, Y., Nakakura, T., Mizukami, H., Kume, A., Okuda, K., Ozawa, K.
- Journal Title
  
  Mol Ther 13
  
  Pages: 823-8
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591007
[Journal Article] The induction of robust immune responses against HIV is supported by the inherent tropism of AAV5 for DC.2006
- Author(s)
  Xin, KQ., Mizukami, H., Urabe, M., Toda, Y., Shinoda, K., Yoshida, A., Oomura, K., Kojima, Y., Ichino, M., Klinman, D., Ozawa K., Okuda, K.
- Journal Title
  
  J Virol 80
  
  Pages: 11899-910
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591007
[Journal Article] A histone deacetylase inhibitor enhances recombinant adeno-associated virus-mediated gene expression in tumor cells.2006
- Author(s)
  Okada, T., Uchibori, R., Iwata-Okada, M., Takahashi, M., Nomoto, T., Nonaka-Sarukawa, M., Ito, T., Liu, Y., Mizukami, H., Kume, A., Kobayashi, E., Ozawa, K.
- Journal Title
  
  Mol Ther 13
  
  Pages: 738-46
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591007
[Journal Article] Scalable generation of high-titer recombinant adeno-associated virus type 5 in insect cells.2006
- Author(s)
  Urabe, M., Nakakura, T., Xin, K.Q., Obara, Y., Mizukami, H., Kume, A., Kotin, R.M., Ozawa, K.
- Journal Title
  
  J. Virol. 80
  
  Pages: 1874-1885
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016067
[Journal Article] Adipose tissue as a novel target for in vivo gene transfer by adeno-associated viral vectors.2006
- Author(s)
  Mizukami, H., Mimuro, J., Ogura, T., Okada, T., Urabe, M., Kume, A., Sakata, Y., Ozawa, K.
- Journal Title
  
  Hum. Gene Ther. 17
  
  Pages: 921-928
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016067
[Journal Article] Removal of empty capsids from type 1 adeno-associated virus vector stocks by anion-exchange chromatography potentiates transgene expression.2006
- Author(s)
  Urabe, M., Xin, K.Q., Obara, Y., Nakakura, T., Mizukami, H., Kume, A., Okuda, K., Ozawa, K.
- Journal Title
  
  Mol.Ther. 13
  
  Pages: 823-828
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390281
[Journal Article] Phenotype correction of hemophilia A mice with adeno-associated virus vectors carrying the B domain-deleted canine factor VIII gene.2006
- Author(s)
  Ishiwata, A., Mimuro, J., Kashiwakura, Y., Niimura, M., Takano, K., Ohmori, T., Madoiwa, S., Mizukami, H., Okada, T., Naka, H., Yoshioka, A., Ozawa, K., Sakata, Y.
- Journal Title
  
  Thromb. Res. 118
  
  Pages: 627-635
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016067
[Journal Article] Adipose tissue as a novel target for in vivo gene transfer by using adeno-associated virus vectors.2006
- Author(s)
  Mizukami H et al.
- Journal Title
  
  Human Gene Therapy 17・9
  
  Pages: 921-928
- Data Source
  KAKENHI-PROJECT-17659328
[Journal Article] Specific and efficient transduction of cochlear inner hair cells with recombinant adeno-associated virus type 3 vector.2005
- Author(s)
  Liu, Y., Okada, T., Sheykholeslami, K., Shimazaki, K., Nomoto, T., Muramatsu, S., Kanazawa, T., Takeuchi, K., Ajalli, R., Mizukami, H., Kume, A., Ichimura, K., Ozawa, K.
- Journal Title
  
  Mol Ther 12
  
  Pages: 725-33
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591007
[Journal Article] Repair of articular cartilage defect by intraarticular administration of basic fibroblast growth factor gene, using adeno-associated virus vector.2005
- Author(s)
  Hiraide, A., Yokoo, N., Xin, KQ., Okuda, K., Mizukami, H., Ozawa, K., Saito, T.
- Journal Title
  
  Hum Gene Ther 16
  
  Pages: 1413-21
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591007
[Journal Article] Large-scale production of recombinant viruses by use of a large culture vessel with active gassing.2005
- Author(s)
  Okada, T., Nomoto, T., Yoshioka, T., Nonaka-Sarukawa, M., Ito, T., Ogura, T., Iwata-Okada, M., Uchibori, R., Shimazaki, K., Mizukami, H., Kume, A., Ozawa, K.
- Journal Title
  
  Hum.Gene Ther. 16
  
  Pages: 1212-1218
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390281
[Journal Article] Repair of articular cartilage defect by autologous transplantation of basic fibroblast growth factor gene-transduced chondrocytes with adeno-associated virus vector.2005
- Author(s)
  Yokoo, N., Saito, T., Uesugi, M., Kobayashi, N., Xin, K.Q., Okuda, K., Mizukami, H., Ozawa, K., Koshino, T.
- Journal Title
  
  Arthritis Rheum. 52
  
  Pages: 164-170
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016067
[Journal Article] Large-scale production of recombinant viruses by use of a large culture vessel with active gassing.2005
- Author(s)
  Okada, T., Nomoto, T., Yoshioka, T., Nonaka-Sarukawa, M., Ito, T., Ogura, T., Iwata-Okada, M., Uchibori, R., Shimazaki, K., Mizukami, H., Kume, A., Ozawa, K.
- Journal Title
  
  Hum. Gene Ther. 16
  
  Pages: 1212-1218
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016067
[Journal Article] Specific and efficient transduction of cochlear inner hair cells with recombinant adeno-associated virus type 3 vector.2005
- Author(s)
  Liu, Y., Okada, T., Sheykholeslami, K., Shimazaki, K., Nomoto, T., Muramatsu, S., Kanazawa, T., Takeuchi, K., Ajalli, R., Mizukami, H., Kume, A., Ichimura, K., Ozawa, K.
- Journal Title
  
  Mol. Ther. 12
  
  Pages: 725-733
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016067
[Journal Article] Repair of articular cartilage defect by autologous transplantation of basic fibroblast growth factor gene-transduced chondrocytes with adeno-associated virus vector.2005
- Author(s)
  Yokoo, N., Saito, T., Uesugi, M., Kobayashi, N., Xin, K.Q., Okuda, K., Mizukami, H., Ozawa, K., Koshino, T.
- Journal Title
  
  Arthritis Rheum. 52
  
  Pages: 164-170
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390281
[Journal Article] Specific and efficient transduction of cochlear inner hair cells with recombinant adeno-associated virus type 3 vector.2005
- Author(s)
  Liu, Y., Okada, T., Sheykholeslami, K., Shimazaki, K., Nomoto, T., Muramatsu, S., Kanazawa, T., Takeuchi, K., Ajalli, R., Mizukami, H., Kume, A., Ichimura, K., Ozawa, K.
- Journal Title
  
  Mol.Ther. 12
  
  Pages: 725-733
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390281
[Journal Article] Repair of articular cartilage defect by intraarticular administration of basic fibroblast growth factor gene, using adeno-associated virus vector.2005
- Author(s)
  Hiraide, A., Yokoo, N., Xin, K.Q., Okuda, K., Mizukami, H., Ozawa, K., Saito, T.
- Journal Title
  
  Hum.Gene Ther. 16
  
  Pages: 1413-1421
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390281
[Journal Article] Topoisomerase inhibitors enhance the cytocidal effect of AAV-HSVtk/ganciclovir on head and neck cancer cells.2004
- Author(s)
  Kanazawa, T., Mizukami, H., Nishino, H., Okada, T., Hanazono, Y., Kume, A., Kitamura, K., Ichimura, K., Ozawa, K.
- Journal Title
  
  Int.J.Oncol. 25
  
  Pages: 729-735
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390281
[Journal Article] Adeno-Associated Virus(AAV) vector-mediated liver- and muscle-directed transgene expression using various kinds of promoters and serotypes.2004
- Author(s)
  Mochizuki, S., Mizukami, H., Kume, A., Muramatsu, S., Takeuchi, K., Matsushita, T., Okada, T., Kobayashi, E., Hoshika, A., Ozawa K.
- Journal Title
  
  Gene Ther and Mol Biol 8
  
  Pages: 9-18
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591022
[Journal Article] The adenovirus E1A and E1B19K genes provide a helper function for transfection-based adeno-associated virus vector production.2004
- Author(s)
  Matsushita, T., Okada, T., Inaba, T., Mizukami, H., Ozawa, K., Colosi, P.
- Journal Title
  
  J.Gen.Virol. 85
  
  Pages: 2209-2214
- NAID
  110006452410
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390281
[Journal Article] Successful gene transfer using adeno-associated virus vectors into the kidney : comparison among adeno-associated virus serotype 1 to 5 vectors in vitro and in vivo.2004
- Author(s)
  Takeda, S., Takahashi, M., Mizukami, H., Kobayashi, E., Takeuchi, K., Hakamata, Y., Kaneko, T., Yamamoto, H., Ito, C., Ozawa, K., Ishibashi, K., Matsuzaki, T., Takata, K., Asano, Y., Kusano, E.
- Journal Title
  
  Nephron Exp.Nephrol. 96
  
  Pages: 119-126
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390281
[Journal Article] Specific detection of human coagulation factor IX in cynomolgus macaques.2004
- Author(s)
  Mimuro, J., Mizukami, H., Ono, F., Madoiwa, S., Terao, K., Yoshioka, A., Ozawa, K., Sakata, Y.
- Journal Title
  
  J Thromb Haemost 2
  
  Pages: 275-280
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591022
[Journal Article] Long-term correction of hyperphenylalaninemia by AAV-mediated gene transfer leads to behavioral recovery in phenylketonuria mice.2004
- Author(s)
  Mochizuki, S., Mizukami, H., Ogura, T., Kure, S., Ichinohe, A., Kojima, K., Matsubara, Y., Kobayashi, E., Okada, T., Hoshika, A., Ozawa, K., Kume, A.
- Journal Title
  
  Gene Ther. 11
  
  Pages: 1081-1086
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390281
[Journal Article] Sustained transgene expression by human cord blood derived CD34(+) cells transduced with simian immunodeficiency virus agmTYO1-based vectors carrying the human coagulation factor VIII gene in NOD/SCID mice.2004
- Author(s)
  Kikuchi, J., Mimuro, J., Ogata, K., Tabata, T., Ueda, Y., Ishiwata, A., Kimura, K., Takano, K., Madoiwa, S., Mizukami, H., Hanazono, Y., Kume, A., Hasegawa, M., Ozawa, K., Sakata, Y.
- Journal Title
  
  J Gene Med. 6
  
  Pages: 1049-1060
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390281
[Journal Article] Separate control of Rep and Cap expression utilizing mutant and wild-type loxP sequences and improved packaging system for adeno-associated virus vector production.2004
- Author(s)
  Mizukami.H., Okada, T., Ogasawara, Y., Matsushita, T., Urabe, M., Kume, A., Ozawa, K.
- Journal Title
  
  Mol Biotechnol 27
  
  Pages: 7-14
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591022
[Journal Article] Expansion of genetically corrected neutrophils in chronic granulomatous disease mice by cotransferring a therapeutic gene and a selective amplifier gene.2004
- Author(s)
  Hara, T., Kume, A., Hanazono, Y., Mizukami, H., Okada, T., Tsurumi, H., Moriwaki, H., Ueda, Y., Hasegawa, M., Ozawa, K.
- Journal Title
  
  Gene Ther. 11
  
  Pages: 1370-1377
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390281
[Journal Article] Separate control of Rep and Cap expression utilizing mutant and wild-type loxP sequences and improved packaging system for adeno-associated virus vector production.2004
- Author(s)
  Mizukami H, et al.
- Journal Title
  
  Mol Biotech 27・1
  
  Pages: 7-14
- Data Source
  KAKENHI-PROJECT-15591022
[Journal Article] Presynaptic localization of neprilysin contributes to efficient clearance of amyloid-beta peptide in mouse brain.2004
- Author(s)
  Iwata, N., Mizukami, H., Shirotani, K., Takaki, Y., Muramatsu, S., Lu, B., Gerard, N.P., Gerard, C., Ozawa, K., Saido, T.C.
- Journal Title
  
  J.Neurosci 24
  
  Pages: 991-998
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591022
[Journal Article] Separate control of Rep and Cap expression utilizing mutant and wild-type loxP sequences and improved packaging system for adeno-associated virus vector production.2004
- Author(s)
  Mizukami, H.
- Journal Title
  
  Mol.Biotechnol. 27・1
  
  Pages: 7-14
- Data Source
  KAKENHI-PROJECT-16390281
[Journal Article] Separate control of Rep and Cap expression utilizing mutant and wild-type loxP sequences and improved packaging system for adeno-associated virus vector production.2004
- Author(s)
  Mizukami, H.
- Journal Title
  
  Mol.Biotechnol. 27・1
  
  Pages: 7-14
- Data Source
  KAKENHI-PROJECT-15025268
[Journal Article] Separate control of Rep and Cap expression utilizing mutant and wild-type loxP sequences and improved packaging system for adeno-associated virus vector production.2004
- Author(s)
  Mizukami, H.
- Journal Title
  
  Mol. Biotechnol. 27・1
  
  Pages: 7-14
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390281
[Journal Article] Sustained transgene expression by human cord blood derived CD34(+) cells transduced with simian immunodeficiency virus agmTYO1-based vectors carrying the human coagulation factor VIII gene in NOD/SCID mice.2004
- Author(s)
  Kikuchi, J., Mimuro, J., Ogata, K., Tabata, T., Ueda, Y., Ishiwata, A., Kimura, K., Takano, K., Madoiwa, S., Mizukami H., Hanazono, Y., Kume, A., Hasegawa, M., Ozawa, K., Sakata, Y.
- Journal Title
  
  J Gene Med 6
  
  Pages: 1049-1060
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591022
[Journal Article] Adeno-associated virus (AAV) vector-mediated liver- and muscle-directed transgene expression using various kinds of promoters and serotypes.2004
- Author(s)
  Mochizuki, S., Mizukami, H., Kume, A., Muramatsu, S., Takeuchi, K., Matsushita, T., Okada, T., Kobayashi, E., Hoshika, A., Ozawa K.
- Journal Title
  
  Gene Ther.Mol.Biol. 8
  
  Pages: 9-18
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390281
[Journal Article] Adeno-associated virus vector-mediated interleukin-10 gene transfer inhibits atherosclerosis in apolipoprotein E-deficient mice.2004
- Author(s)
  Yoshioka, T., Okada, T., Maeda, Y., Ikeda, U., Shimpo, M., Nomoto, T., Takeuchi, K., Nonaka-Sarukawa, M., Ito, T., Takahashi, M., Matsushita, T., Mizukami, H., Hanazono, Y., Kume, A., Ookawara, S., Kawano, M., Ishibashi, S., Shimada, K., Ozawa, K.
- Journal Title
  
  Gene Ther. 11
  
  Pages: 1772-1779
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390281
[Journal Article] Long-term correction of hyperphenylalaninemia by AAV-mediated gene transfer leads to behavioral recovery in phenylketonuria mice.2004
- Author(s)
  Mochizuki, S., Mizukami, H., Ogura, T., Kure, S., Ichinohe, A., Kojima, K., Matsubara, Y., Kobayashi, E., Okada, T., Hoshika, A., Ozawa, K., Kume, A.
- Journal Title
  
  Gene Ther 11
  
  Pages: 1081-1086
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591022
[Journal Article] Adeno-associated virus vector-mediated interleukin-10 gene transfer inhibits atherosclerosis in apolipoprotein E-deficient mice.2004
- Author(s)
  Yoshioka, T., Okada, T., Maeda, Y., Ikeda, U., Shimpo, M., Nomoto, T., Takeuchi, K., Nonaka-Sarukawa, M., Ito, T., Takahashi, M., Matsushita, T., Mizukami, H., Hanazono, Y., Kume, A., Ookawara, S., Kawano, M., Ishibashi, S., Shimada, K., Ozawa, K.
- Journal Title
  
  Gene Ther 11
  
  Pages: 1772-1779
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591022
[Journal Article] Separate control of Rep and Cap expression utilizing mutant and wild-type loxP sequences and improved packaging system for adeno-associated virus vector production.2004
- Author(s)
  Mizukami, H., Okada, T., Ogasawara, Y., Matsushita, T., Urabe, M., Kume, A., Ozawa, K.
- Journal Title
  
  Mol.Biotechnol. 27
  
  Pages: 7-14
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390281
[Journal Article] Topoisomerase inhibitors enhance the cytocidal effect of AAV-HSVtk/ganciclovir on head and neck cancer cells.2004
- Author(s)
  Kanazawa, T., Mizukami, H., Nishino, H., Okada, T., Hanazono, Y., Kume, A., Kitamura, K., Ichimura, K., Ozawa, K.
- Journal Title
  
  Int J Oncol 25
  
  Pages: 729-735
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591022
[Journal Article] Presynaptic localization of neprilysin contributes to efficient clearance of amyloid-b peptide in mouse brain.2004
- Author(s)
  Iwata, N., Mizukami, H., Shirotani, K., Takaki, Y., Muramatsu, S., Lu, B., Gerard, N.P., Gerard, C., Ozawa, K.Saido, T.C.
- Journal Title
  
  J.Neurosci. 24
  
  Pages: 991-998
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390281
[Journal Article] Separate control of Rep and Cap expression utilizing mutant and wild-type loxP sequences and improved packaging system for adeno-associated virus vector production.2004
- Author(s)
  Mizukami H, et al.
- Journal Title
  
  Mol Biotech 27
  
  Pages: 7-14
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591022
[Journal Article] Suppression of cell migration in ovarian cancer cells mediated by PTEN overexpression.2003
- Author(s)
  Saga, Y., Mizukami, H., Takei, Y., Ozawa, K., Suzuki, M.
- Journal Title
  
  Int J Oncol 23
  
  Pages: 1109-1113
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591022
[Journal Article] Suicide gene therapy using AAV-HSVtk/ganciclovir in combination with irradiation results in regression of human head and neck cancer xenografts in nude mice.2003
- Author(s)
  Kanazawa, T., Mizukami, H., Okada, T., Hanazono, Y., Kume, A., Nishino, A., Takeuchi, K., Kitamura, K., Ichimura, K., Ozawa, K.
- Journal Title
  
  Gene Ther 10
  
  Pages: 51-58
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591022
[Journal Article] Interleukin-10-mediated inhibition of angiogenesis and tumor growth in mice bearing VEGF-producing ovarian cancer.2003
- Author(s)
  Kohno, T., Mizukami, H., Suzuki, M., Saga, Y., Takei, Y., Shimpo, M., Matsushita, T., Okada, T., Hanazono, Y., Kume, A., Sato, I., Ozawa, K.
- Journal Title
  
  Cancer Res 63
  
  Pages: 5091-5094
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591022
[Journal Article] Persistent phenotypic correction of central diabetes insipidus using adeno-associated virus vector-expressing arginine-vasopressin in brattleboro rats.2003
- Author(s)
  Ideno, J., Mizukami, H., Honda, K., Okada, T., Hanazono, Y., Kume, A., Saito, T., Ishibashi, S., Ozawa, K.
- Journal Title
  
  Mol Ther 8
  
  Pages: 895-902
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591022
[Journal Article] Utility of intraperitoneal administration as a route of AAV serotype 5 vector-mediated neonatal gene transfer.
- Author(s)
  Ogura, T., Mizukami, H., Mimuro, J., Madoiwa, S., Okada, T., Matsushita, T., Urabe, M., Kume, A., Hamada, H., Yoshikawa, H., Sakata, Y., Ozawa, K.
- Journal Title
  
  J.Gene Med. (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390281
[Patent] Method of treating amino acid meta- bolic disorders using recombinant adeno-associated virus virions2003
- Inventor(s)
  Keiya Ozawa, Hiroaki Mizukami, Akihiro Kume
- Industrial Property Rights Holder
  Keiya Ozawa, Hiroaki Mizukami, Akihiro Kume
- Filing Date
  2003-04-16
- Data Source
  KAKENHI-PROJECT-15591022
[Patent] Method of treating amino acid metabolic disorders using recombinant adeno-associated virus virions2003
- Inventor(s)
  Keiya Ozawa, Hiroaki Mizukami, Akihiro Kume
- Industrial Property Rights Holder
  Keiya Ozawa, Hiroaki Mizukami, Akihiro Kume
- Filing Date
  2003-04-16
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591022
[Patent] Methods for treating and preventing vascular disease2003
- Inventor(s)
  小澤敬也, 野本達也, 岡田尚巳, 水上浩明
- Industrial Property Rights Holder
  小澤敬也, 野本達也, 岡田尚巳, 水上浩明
- Filing Date
  2003-10-20
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591022
[Presentation] アデノ随伴ウイルスを用いた腹膜へのマイクロRNA-29b導入は胃癌腹膜播種を抑制する2024
- Author(s)
  金子勇貴, 大澤英之, 木村勇希, 高橋礼, 松宮美沙希, 田村昂平, 風當ゆりえ, 宮戸秀世, 山口博紀, 細谷好則, 綿野亮太, 水上浩明, 佐田尚宏,北山丈二.
- Organizer
  第96回日本胃癌学会総会
- Data Source
  KAKENHI-PROJECT-23K27676
[Presentation] A Replication-Competent Vaccinia Virus LC16m8Δ2/AAV1-Based malaria vaccine versus RTS, S/AS01E in a Murine Model2024
- Author(s)
  Hasyim Ammar Abdurrahman、Zainal Kartika Hardianti、山本祐太朗、水野哲志、大浦祐人、岡橋侑渡、林久輝、高木里菜、佐藤侑奈、宮浦茉奈、Rasyid Sani Hadiyan、伊從光洋、水上浩明、志田壽利、吉田栄人
- Organizer
  第93回日本寄生虫学会大会
- Data Source
  KAKENHI-PROJECT-23K24375
[Presentation] Intracavitary gene therapy using miRNA-29b-encoding adeno-associated virus for peritoneal dissemination.2024
- Author(s)
  Y. Kaneko, H. Ohzawa, Y. Kimura, R. Takahashi, M. Matsumiya, K. Tamura, Y. Futoh, H. Miyato, R. Watano, H. Mizukami, N. Sata, J. Kitayama.
- Organizer
  American Association for Cancer Research 2024
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27676
[Presentation] Development of Epitope-Lacking Transgenic Rodent Malaria Parasite as an Approach for Assessing Vaccine Mechanism of Protection2024
- Author(s)
  Rasyid Sani Hadiyan、村井駿介、奥山竣介、吉田涼翔、水野哲志、山本祐太朗、伊從光洋、福本晋也、水上浩明、志田壽利、吉田栄人
- Organizer
  第93回日本寄生虫学会大会
- Data Source
  KAKENHI-PROJECT-23K24375
[Presentation] 三日熱マラリアユニーバーサルワクチン開発（マウスモデル）-3種のPvCSP変異型アレルに対応-2024
- Author(s)
  矢坂悠人、山本祐太朗、水上浩明、志田壽利、伊從光洋、吉田栄人
- Organizer
  第93回日本寄生虫学会大会
- Data Source
  KAKENHI-PROJECT-23K24375
[Presentation] Humoral immune responses to the central repeat region of PfCSP induced by a vial-vectored plasmodium falciparum vaccine play critical roles in protection in a murine model2023
- Author(s)
  Shunsuke Okuyama, Yutaro Yamamoto, Shunsuke Murai, Mitsuhiro Iyori, Tetsushi Mizuno, Akihiko Sakamoto, Shinya Fukumoto, Hiroaki Mizukami, Hisatoshi Shida, Shigeto Yoshida
- Organizer
  ASTMH 2023 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24375
[Presentation] 新型コロナウイルスに対する2種のウイルスベクターワクチンを用いることによる相乗的な免疫応答の解析2023
- Author(s)
  山形恭平、坂本明彦、橋本ひなた、山内彩椰、水野哲志、小川良平、三橋慧吾、車京儒、坪内貴之、山本祐太朗、伊從光洋、水上浩明、志田壽利、吉田栄人
- Organizer
  第70回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24375
[Presentation] A Head-to-Head comparative study of the LC16m8Δ/AAV vaccine versus RTS,S/AS01E vaccine in murine models2023
- Author(s)
  Zainal Kartika Hardianti、Hasyim Ammar Abdurrahman、山本祐太朗、大浦祐人、岡橋侑渡、林久輝、高木里菜、佐藤侑奈、宮浦茉奈、Rasyid Sani Hadiyan、伊從光洋、水上浩明、志田壽利、吉田栄人
- Organizer
  第78回日本寄生虫学会西日本支部大会
- Data Source
  KAKENHI-PROJECT-23K24375
[Presentation] P. falciparum-P. vivax bivalent vaccine development using LC16m8Δ/AAV viral vectors platform achieves sterile protection and transmission blocking2023
- Author(s)
  Yutaro Yamamoto, Camila Fabbri, Takuto Katayama, Tetushi Mizuno, Akihiko Sakamoto, Ammar Abdurrahman Hasyim, Shunsuke Okuyama, Sani Hadiyan Rasyid, Mitsuhiro Iyori, Hiroaki Mizukami, Hisatoshi Shida, StefanieLopes, Shigeto Yoshida
- Organizer
  ASTMH 2023 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24375
[Presentation] Conquering Plasmodium vivax: LC16m8Δ/AAV Vaccine Strategy on Protection and Transmission-Blockade2023
- Author(s)
  Yutaro Yamamoto, Camila Fabbri, Takuto Katayama, Sora Niwa, Tetushi Mizuno, Akihiko Sakamoto, Ammar Abdurrahman, Sani Hadiyan Rasyid, Mitsuhiro Iyori, Hiroaki Mizukami, Hisatoshi Shida, Stefanie Lopes, Shigeto Yoshida
- Organizer
  第21回松山国際学術シンポジウム＆ PRiME 共同研究発表会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24375
[Presentation] 熱帯熱マラリア・COVID-19・サル痘に有効な3価ワクチンの開発研究2023
- Author(s)
  佐藤侑奈、山本祐太朗、坂本明彦、伊從光洋、森田武志、渡士幸一、水上浩明、志田壽利、吉田栄人
- Organizer
  第92回日本寄生虫学会大会
- Data Source
  KAKENHI-PROJECT-23K24375
[Presentation] ウイルスベクターよりなる熱帯熱-三日熱マラリア2価ワクチンの開発と有効性の検証2023
- Author(s)
  片山拓和、山本祐太朗、FABBRI Camila、水野哲志、伊從光洋、水上浩明、志田壽利、LOPES Stefanie Costa Pinto、吉田栄人
- Organizer
  第92回日本寄生虫学会大会
- Data Source
  KAKENHI-PROJECT-23K24375
[Presentation] 前臨床試験におけるマラリアマルチステージワクチンの感染防御効果と伝搬阻止効果2023
- Author(s)
  伊從光洋、BLAGBOROUGH Andrew、水野哲志、阿部優一、DA Dari、WILLIAM Gregory、水上浩明、志田壽利、吉田栄人
- Organizer
  第92回日本寄生虫学会大会
- Data Source
  KAKENHI-PROJECT-23K24375
[Presentation] LC16m8Δ2/AAV1ウイルスプラットフォームを基盤とした熱帯熱および三日熱マラリアに対する乳幼児用マルチステージ2価ワクチンの開発研究2023
- Author(s)
  山本祐太朗、片山拓和、Fabbri Camila、水野哲志、坂本明彦、伊從光洋、水上浩明、志田壽利、Lopes Stefanie Costa Pinto、吉田栄人
- Organizer
  第29回分子寄生虫学ワークショップ／第19回分子寄生虫・マラリア研究フォーラム
- Data Source
  KAKENHI-PROJECT-23K24375
[Presentation] 感染防御・伝播阻止両機能を有する次世代型三日熱マラリアマルチステージワクチン開発研究2023
- Author(s)
  山本祐太朗、Fabbri Camila、奥原大輝、片山拓和、坂本明彦、水上浩明、志田壽利、伊從光洋、水野哲志、Lopes Stefanie、吉田栄人
- Organizer
  第92回日本寄生虫学会大会
- Data Source
  KAKENHI-PROJECT-23K24375
[Presentation] P. falciparum- P.vivax bivalent vaccine development using LC16m8Δ/AAV viral vectors platform2023
- Author(s)
  Yutaro Yamamoto, Camila Fabbri, Takuto Katayama, Tetushi Mizuno, Akihiko Sakamoto, Ammar Abdurrahman Hasyim, Shunsuke Murai, Sani Hadiyan Rasyid, Mitsuhiro Iyori, Hiroaki Mizukami, Hisatoshi Shida, Stefanie Lopes, Shigeto Yoshida
- Organizer
  BioMalPar XVIII: biology and pathology of the malaria parasite
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24375
[Presentation] 熱帯熱マラリアワクチンLC16m8Δ/AAVの感染防御メカニズムの解析2023
- Author(s)
  奥山竣介、山本祐太朗、村井駿介、水野哲志、佐藤侑奈、伊從光洋、福本晋也、水上浩明、志田壽利、吉田栄人
- Organizer
  第78回日本寄生虫学会西日本支部大会
- Data Source
  KAKENHI-PROJECT-23K24375
[Presentation] AAV1 and AAV5 as a malaria booster vaccine following priming with LC16m8Δ2023
- Author(s)
  Ammar A. Hasyim, Mitsuhiro Iyori, Tetsushi Mizuno, Yu-ichi Abe, Iroha Yamagoshi, Yenni Yusuf, Intan Syafira, Akihiko Sakamoto, Yutaro Yamamoto, Hiroaki Mizukami, Hisatoshi Shida, and Shigeto Yoshida
- Organizer
  第21回松山国際学術シンポジウム＆ PRiME 共同研究発表会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24375
[Presentation] 三日熱マラリア撲滅へ向けて -次世代型ウイルスベクター（LC16m8Δ/AAV）を用いた三日熱マラリアマルチステージワクチン開発研究-2023
- Author(s)
  仁和空、山本祐太朗、Fabbri Camila、片山拓和、坂本明彦、水上浩明、志田壽利、伊從光洋、Lopes Stefanie、吉田栄人
- Organizer
  日本薬学会北陸支部第135回例会
- Data Source
  KAKENHI-PROJECT-23K24375
[Presentation] 汎用的・持続可能な感染防御と伝播阻止効果を発揮する三日熱マラリアワクチンの開発2023
- Author(s)
  仁和空、山本祐太朗、Fabbri Camila、片山拓和、坂本明彦、水上浩明、志田壽利、伊従光洋、Lopes Stefanie Costa Pinto、吉田栄人
- Organizer
  第78回日本寄生虫学会西日本支部大会
- Data Source
  KAKENHI-PROJECT-23K24375
[Presentation] Evaluation of Multistage Malaria Vaccine Using Transgenic Epitope-Deficient Rodent Malaria Parasite as a Tool for Assessing Mechanism of Protection2023
- Author(s)
  Sani Hadiyan Rasyid, Okuyama Shunsuke, Shunsuke Murai, Tetsushi Mizuno, Yutaro Yamamoto, Mitsuhiro Iyori, Shinya Fukumoto, Hiroaki Mizukami, Hisatoshi Shida, Shigeto Yoshida
- Organizer
  第21回松山国際学術シンポジウム＆ PRiME 共同研究発表会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24375
[Presentation] Multistage malaria booster vaccine based on Adeno-associated virus serotype 5 induces sterile protection and blocks parasite transmission2023
- Author(s)
  Hasyim Ammar A.、水野哲志、阿部優一、山越彩葉、Yusuf Yenni、Syafira Intan、坂本明彦、山本祐太朗、伊從光洋、水上浩明、志田壽利、吉田栄人
- Organizer
  第92回日本寄生虫学会大会
- Data Source
  KAKENHI-PROJECT-23K24375
[Presentation] The synergy of the multi-stage vaccine against Plasmodium falciparum enhances the reduction of parasite prevalence in a murine model2023
- Author(s)
  水野哲志、Blagborough Andrew、新倉保、Hasyim Ammar A.、伊從光洋、山本祐太朗、坂本明彦、水上浩明、志田壽利、吉田栄人
- Organizer
  第92回日本寄生虫学会大会
- Data Source
  KAKENHI-PROJECT-23K24375
[Presentation] Plasmodium vivax multistage vaccine based on the heterologous viral-vectored platform achieves sterile protection and transmission blocking2022
- Author(s)
  Yamamoto Yutaro, Fabbri Camila, Okuhara Daiki, Katayama Takuto, Takagi Rina, Kawabata Yuna, Iyori Mitsuhiro, Mizuno Tetsushi, Sakamoto Akihiko, Hasyim Ammar A., Mizukami Hiroaki, Shida Hisatoshi, Lopes Stefanie, Yoshida Shigeto
- Organizer
  ASTMH 2022 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24375
[Presentation] Pre-erythrocytic and transmission-blocking multi-stage malaria vaccine strategy shows a strong synergic effect to control malaria disease2022
- Author(s)
  Mizuno Tetsushi, Blagborough Andrew M., Niikura Mamoru, Hasyim Ammar A., Iyori Mitsuhiro, Yamamoto Yutaro, Sakamoto Akihiko, Mizukami Hiroaki, Shida Hisatoshi, Yoshida Shiget
- Organizer
  ASTMH 2022 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24375
[Presentation] 組換えワクシニアウイルスベクターのin vitro発現量増強とin vivo免疫原性・ワクチン効果との相関解析2022
- Author(s)
  宮部諒、山本祐太朗、Zainal Kartika Hardianti、HASYIM Ammar Abdurrahman、阿部優一、仁和空、水野哲志、伊從光洋、志田壽利、水上浩明、吉田栄人
- Organizer
  第69回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24375
[Presentation] A Novel Malaria Multistage Vaccine Based on Vaccinia virus-Prime/AAV5-Boost Elicits Sterile Protection and Transmission Blocking Efficacy2022
- Author(s)
  Hasyim Ammar A., Iyori Mitsuhiro, Mizuno Tetsushi, Abe Yu-ichi, Mizukami Hiroaki, Yamagoshi Iroha, Yusuf Yenni, Syafira Intan, Sakamoto Akihiko, Yamamoto Yutaro, Shida Hisatoshi, Yoshida Shigeto
- Organizer
  ASTMH 2022 Annual Meeting
- Data Source
  KAKENHI-PROJECT-23K24375
[Presentation] 三日熱マラリアに対する次世代型マルチステージワクチン開発研究2022
- Author(s)
  山本祐太朗、FABBRI Camila、奥原大輝、高木里菜、川端裕菜、片山拓和、水上浩明、志田壽利、伊從光洋、LOPES Stefanie Costa Pinto、吉田栄人
- Organizer
  第26回日本ワクチン学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24375
[Presentation] 弱毒化ワクシニアウイルス/アデノ随伴ウイルスよりなる三日熱マラリアワクチン開発研究2022
- Author(s)
  奥原大輝、山本祐太朗、FABBRI Camila、高木里菜、川端裕菜、片山拓和、水上浩明、志田壽利、伊從光洋、LOPES Stefanie Costa Pinto、吉田栄人
- Organizer
  第69回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24375
[Presentation] 次世代型組換えウイルスベクター（LC16m8Δ/AAV）を用いた熱帯熱-三日熱マラリア2価ワクチン開発2022
- Author(s)
  片山拓和、山本祐太朗、奥原大輝、伊從光洋、水上浩明、志田壽利、吉田栄人
- Organizer
  第69回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24375
[Presentation] Optimization of Plasmodium falciparum multistage vaccine based on the heterologous viral-vectored platform in a murine mod2022
- Author(s)
  Miyabe Ryo, Yamamoto Yutaro, Zainal Kartika H., Hasyim Ammar A., Abe Yu-ichi, Iyori Mitsuhiro, Mizuno Tetsushi, Sakamoto Akihiko, Mizukami Hiroaki, Shida Hisatoshi, Yoshida Shigeto
- Organizer
  ASTMH 2022 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24375
[Presentation] Long-term expression of coagulation factor IX gene transduced by AAV8 into macaques2015
- Author(s)
  Mizukami H, Ohmori T, Uchibori R, Tsukahara T, Saga, Y, Urabe M, Kume A, Sakata Y, Ozawa K
- Organizer
  日本血液学会
- Place of Presentation
  金沢
- Year and Date
  2015-10-17
- Data Source
  KAKENHI-PROJECT-25461460
[Presentation] Long-term efficacy of factor IX gene expression following AAV8-mediated liver transduction in macaques2015
- Author(s)
  Mizukami H, Ohmori T, Uchibori R, Tsukahara T, Saga, Y, Urabe M, Kume A, Sakata Y, Ozawa K.
- Organizer
  日本遺伝子治療学会
- Place of Presentation
  大阪
- Year and Date
  2015-07-25
- Data Source
  KAKENHI-PROJECT-25461460
[Presentation] Persistent factor IX expression following AAV8-mediated liver transduction in macaques2015
- Author(s)
  Mizukami H, Ohmori T, Uchibori R, Tsukahara T, Saga, Y, Urabe M, Kume A, Sakata Y, Ozawa K
- Organizer
  欧州遺伝子細胞治療学会
- Place of Presentation
  ヘルシンキ
- Year and Date
  2015-09-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461460
[Presentation] Age-related eligibility of hemophilia gene therapy using AAV vectors2014
- Author(s)
  Mizukami H, et al.
- Organizer
  The 76th Annual Meeting of the Japanese Society of Hematology
- Place of Presentation
  Osaka
- Year and Date
  2014-11-01
- Data Source
  KAKENHI-PROJECT-25461460
[Presentation] IMMUNE RESPONSES IN HEMOPHILIA GENE THERAPY2014
- Author(s)
  Mizukami H
- Organizer
  The 20th Annual Meeting of Japan Society of Gene Therapy
- Place of Presentation
  Tokyo
- Year and Date
  2014-08-07
- Invited
- Data Source
  KAKENHI-PROJECT-25461460
[Presentation] Low Prevalence of Neutralizing Antibody against AAV capsids in Young Japanese Population2014
- Author(s)
  Mizukami H, Mimuro J, Tsukasa O, Madoiwa S, Sakata Y, Ozawa K
- Organizer
  15th International Parvovirus Workshop
- Place of Presentation
  Bordeaux, France
- Year and Date
  2014-06-25
- Data Source
  KAKENHI-PROJECT-25461460
[Presentation] Precise evaluation of NAb against AAV vectors and approaches toward managing its inhibitory effect2013
- Author(s)
  Mizukami H, Mimuro J, Uchibori R, Tsukahara T, Urabe M, Kume A, Sakata A, Ohmori T, Madoiwa S, Sakata Y, Ozawa K
- Organizer
  第75回日本血液学会学術集会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-25461460
[Presentation] Accurate measurement of NAb status against AAV vector capsids and an approach toward managing its inhibitory effect2013
- Author(s)
  Mizukami H, Mimuro J, Hishikawa S, Ikemoto T, Uchibori R, Tsukahara T, Urabe M, Kume A, Sakata A, Ohmori T, Madoiwa S, Sakata Y, Ozawa K
- Organizer
  21st Annual Congress European Society for Gene and Cell Therapy
- Place of Presentation
  Madrid, Spain
- Data Source
  KAKENHI-PROJECT-25461460
[Presentation] 頭頸部扁平上皮癌におけるガラニン受容体2型を介する新たな抗腫瘍機構の解明2012
- Author(s)
  上原貴行,金澤丈治,水上浩明,内堀亮介,塚原智典,卜部匡司,久米晃啓,三澤清,小澤敬也
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23592539
[Presentation] Relationship between neutralizing antibody and factor IX expression in non-human primates following IV administration of AAV8 vectors2011
- Author(s)
  Mizukami H, et al
- Organizer
  American Society of Gene Therapy 14th Annual Meeting
- Place of Presentation
  Seattle, USA
- Year and Date
  2011-05-21
- Data Source
  KAKENHI-PROJECT-21591248
[Presentation] Relationship between neutralizing antibody and factor IX expression in non-human primates following IV administration of AAV8 vectors2011
- Author(s)
  Mizukami H, et al
- Organizer
  American Society of Gene and Cell Therapy's 14th Annual Meeting
- Place of Presentation
  Seattle, USA
- Year and Date
  2011-05-21
- Data Source
  KAKENHI-PROJECT-21591248
[Presentation] Consistent Factor IX Expression in NAb-negative Macaques following IV Administration of AAV8 Vector2011
- Author(s)
  Mizukami H, et al
- Organizer
  第73回日本血液学会学術集会
- Place of Presentation
  名古屋
- Year and Date
  2011-10-14
- Data Source
  KAKENHI-PROJECT-21591248
[Presentation] Optimization of efficacy in AAV-mediated siRNA expression2011
- Author(s)
  Mizukami H, et al
- Organizer
  19^<th> Annual Congress of the European Society of Gene and Cell Therapy
- Place of Presentation
  Brighton, UK
- Year and Date
  2011-10-29
- Data Source
  KAKENHI-PROJECT-21591248
[Presentation] Optimization of efficacy in AAV-mediated siRNA expression2010
- Author(s)
  Mizukami H, et al, Tomonori Tsukahara, Akihiro Kume, Keiya Ozawa, Hiroaki Mizukami, Masashi Urabe
- Organizer
  19^<th> Annual Congress of the European Society of Gene and Cell Therapy
- Place of Presentation
  Brighton, UK
- Year and Date
  2010-10-23
- Data Source
  KAKENHI-PROJECT-21591248
[Presentation] Immune responses in AAVmediated gene transfer2010
- Author(s)
  Mizukami H.
- Organizer
  第16回日本遺伝子治療学会
- Place of Presentation
  宇都宮
- Year and Date
  2010-07-03
- Data Source
  KAKENHI-PROJECT-21591248
[Presentation] Robust and Sustained Factor IX Expression by IV Administration of AAV8-based Vectors in Macaques2010
- Author(s)
  Mizukami H, et al
- Organizer
  American Society of Gene and Cell Therapy's 13th Annual Meeting
- Place of Presentation
  Washington, DC, USA
- Year and Date
  2010-05-27
- Data Source
  KAKENHI-PROJECT-21591248
[Presentation] Unswerving Factor IX Expression in NAb-negative Macaques following IV Administration of AAV8 Vector2010
- Author(s)
  Mizukami H, et al
- Organizer
  18^<th> Annual Congress of the European Society of Gene and Cell Therapy
- Place of Presentation
  Milan, Italy
- Year and Date
  2010-10-23
- Data Source
  KAKENHI-PROJECT-21591248
[Presentation] Improved assay system for NAb against AAV vectors and prevalence in non-human primates2010
- Author(s)
  Mizukami H, et al
- Organizer
  第72回日本血液学会学術集会
- Place of Presentation
  横浜
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-PROJECT-21591248
[Presentation] Robust and Sustained Factor IX Expression by IV Administration of AAV8-based Vectors in Macaques2010
- Author(s)
  Mizukami H, et al.
- Organizer
  American Society of Gene Therapy 13th Annual Meeting
- Place of Presentation
  Washington, DC, USA
- Year and Date
  2010-05-21
- Data Source
  KAKENHI-PROJECT-21591248
[Presentation] IMMUNE RESPONSES IN AAV-MEDIATED GENE TRANSFER2010
- Author(s)
  Mizukami H, et al.
- Organizer
  Japan Society of Gene Therapy 16^<th> Annual Meeting
- Place of Presentation
  宇都宮
- Year and Date
  2010-07-03
- Data Source
  KAKENHI-PROJECT-21591248
[Presentation] Robust and sustained factor IX expression following IV injection of AAV8-based vectors in macaques2009
- Author(s)
  Mizukami H, et al
- Organizer
  第71回日本血液学会学術集会
- Place of Presentation
  京都
- Year and Date
  2009-10-23
- Data Source
  KAKENHI-PROJECT-21591248
[Presentation] Neutralizing antibody affects liver-mediated factor IX expression in non-human primates by AAV vectors2009
- Author(s)
  Mizukami H, et al.
- Organizer
  American Society of Gene Therapy 12th Annual Meeting
- Place of Presentation
  San Diego, CA, USA
- Year and Date
  2009-05-30
- Data Source
  KAKENHI-PROJECT-21591248
[Presentation] Robust and sustained factor IX expression following IV injection of AAV8-based vectors in macaques.2009
- Author(s)
  Mizukami H
- Organizer
  第71回日本血液学会学術集会
- Place of Presentation
  国立京都国際会館(京都)
- Year and Date
  2009-10-23
- Data Source
  KAKENHI-PROJECT-17016067
[Presentation] Relationship between neutralizing antibody and liver-mediated factor IX expression in non-human primates using AAV vectors2009
- Author(s)
  Mizukami H, et al
- Organizer
  17^<th> Annual Congress of the European Society of Gene and Cell Therapy
- Place of Presentation
  Hannover, Germany
- Year and Date
  2009-11-22
- Data Source
  KAKENHI-PROJECT-21591248
[Presentation] Intravenous injection of AAV 8-based vectors results in robust and sustained transgene expression in macaques2009
- Author(s)
  Mizukami,H.
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜(横浜)
- Year and Date
  2009-10-02
- Data Source
  KAKENHI-PROJECT-17016067
[Presentation] Relationship between neutralizing antibody and liver-mediated factor IX expression in non-human primates using AAV vectors.2009
- Author(s)
  Mizukami,H.
- Organizer
  17^<th> Annual Congress of the European Society of Gene and Cell Therapy
- Place of Presentation
  Convention Centre at Hannover Fairground (Germany)
- Data Source
  KAKENHI-PROJECT-17016067
[Presentation] Neutralizing antibody against vector capsid affects liver-mediated factor IX expression in non-human primates using AAV vectors.2009
- Author(s)
  Mizukami,H.
- Organizer
  The 15^<th> Annual Meeting of the Japan Society of Gene Therapy
- Place of Presentation
  大阪大学コンベンションセンター(大阪)
- Year and Date
  2009-07-11
- Data Source
  KAKENHI-PROJECT-17016067
[Presentation] Neutralizing antibody affects liver-mediated factor IX expression in non-human primates by AAV vectors2009
- Author(s)
  Mizukami H, et al
- Organizer
  American Society of Gene and Cell Therapy's 13th Annual Meeting
- Place of Presentation
  San Diego, USA
- Year and Date
  2009-05-30
- Data Source
  KAKENHI-PROJECT-21591248
[Presentation] AAVに対する中和抗体検査法の実用化に向けた改良2009
- Author(s)
  水上浩明
- Organizer
  第57回日本ウイルス学会学術集会
- Place of Presentation
  都市センターホテル(東京)
- Year and Date
  2009-10-27
- Data Source
  KAKENHI-PROJECT-17016067
[Presentation] Neutralizing antibody affects liver-mediated factor IX- expression in non-human primates using AAV vectors.2009
- Author(s)
  Mizukami,H.
- Organizer
  The 12^<th> Annual Meeting of the American Socie of Gene Therapy
- Place of Presentation
  San Diego Convention Center (San Diego)
- Year and Date
  2009-05-30
- Data Source
  KAKENHI-PROJECT-17016067
[Presentation] A sensitive assay for neutralizing antibody against AAV serotypes in cluding 8 and 9.2009
- Author(s)
  Mizukami,H.
- Organizer
  The 15^<th> Annual Meeting of the Japan Society of Gene Therapy
- Place of Presentation
  大阪大学コンベンションセンター(大阪)
- Year and Date
  2009-07-09
- Data Source
  KAKENHI-PROJECT-17016067
[Presentation] Role of inflammatory cytokines in tumor tropism of mesenchimal stromal cells.2008
- Author(s)
  Uchibori R, Ito T, Mizuguchi H, Urabe M, Mizukami H, Kume A, Ozawa K
- Organizer
  The 67^<th> annual meeting of the Japanese Cancer Association(O-369, Abstract p300)
- Place of Presentation
  Nagoya
- Year and Date
  2008-10-27
- Data Source
  KAKENHI-PROJECT-19591134
[Presentation] Establishment of a lymph node metastasis model with endometrial cancer and therapeutic efficacy of AAV vectors encoding sflt-4.2008
- Author(s)
  Takahashi, T., Mizukami, H., Saga, Y., Takei, Y., Urabe, M., Kume, A., Suzuki, M., Ozawa, K.
- Organizer
  The 14^<th> Annual Meeting of Japan Society of Gene Therapy(Abstract #74)
- Place of Presentation
  Sapporo
- Year and Date
  2008-06-14
- Data Source
  KAKENHI-PROJECT-19591134
[Presentation] Unexpected silencing of transgene integrated at AAVS1 locus using AAV machinary.2008
- Author(s)
  Obara Y, Urabe M, Ito T, Mizukami H, Kume A, Ozawa K.
- Organizer
  The 14^<th> Annual Meeting of Japan Society of Gene Therapy(Abstract #11)
- Place of Presentation
  Sapporo
- Year and Date
  2008-06-13
- Data Source
  KAKENHI-PROJECT-19591134
[Presentation] Liver-mediated Factor IX Expression by AAV8 Vector and Neutralizing Antibody in Non-Human Primates2008
- Author(s)
  Mizukami, H
- Organizer
  The 11^<th> Annual Meeting of American Society of Gene Therapy
- Place of Presentation
  Boston
- Year and Date
  2008-05-29
- Data Source
  KAKENHI-PROJECT-17016067
[Presentation] Inhibitory Actions of Very Low Titer Neutralizing Antibody Against AAV8 Capsid Upon Liver-Mediated Factor IX Expression in Non-Human Primates2008
- Author(s)
  Mizukami, H
- Organizer
  The 14^<th> Annual Meeting of Japan Society of Gene Therapy
- Place of Presentation
  Sapporo
- Year and Date
  2008-06-14
- Data Source
  KAKENHI-PROJECT-17016067
[Presentation] AAVベクターを用いた遺伝子導入法と免疫反応-血友病Bに関する検討を中心に2008
- Author(s)
  水上浩明
- Organizer
  第70回日本血液学会総会
- Place of Presentation
  京都
- Year and Date
  2008-10-10
- Data Source
  KAKENHI-PROJECT-19591134
[Presentation] AAVベクターを用いた遺伝子導入法と免疫反応-血友病Bに関する検討を中心に2008
- Author(s)
  水上浩明
- Organizer
  第70回日本血液学会総会
- Place of Presentation
  京都
- Year and Date
  2008-10-10
- Data Source
  KAKENHI-PROJECT-17016067
[Presentation] “Immune responses in gene therapy using adeno-associated vectors"Educational seminar IV, “AAV vectors".2008
- Author(s)
  Mizukami H
- Organizer
  The 14^<th> Annual Meeting of Japan Society of Gene Therapy
- Place of Presentation
  札幌
- Year and Date
  2008-06-13
- Data Source
  KAKENHI-PROJECT-19591134
[Presentation] Immune responses in gene herapy using adeno-associated vectors2008
- Author(s)
  Mizukami, H.
- Organizer
  Educational seminar IV "AAV vectors" The 14^<th> Annual Meeting of Japan Society of Gene Therapy
- Place of Presentation
  Sapporo
- Year and Date
  2008-06-13
- Data Source
  KAKENHI-PROJECT-19591134
[Presentation] 「AAV ベクターを用いた遺伝子治療の現状と展望」自治医科大学21 世紀COE プログラム2008
- Author(s)
  水上浩明、小澤敬也
- Organizer
  第5回合同シンポジウム
- Place of Presentation
  自治医科大学
- Year and Date
  2008-02-02
- Data Source
  KAKENHI-PROJECT-19591134
[Presentation] 遺伝子治療の現状と課題2008
- Author(s)
  水上浩明、小澤敬也
- Organizer
  第28 回医療情報学連合大会
- Place of Presentation
  オーガナイズドセッション「ゲノムインフォマティクス」横浜
- Year and Date
  2008-11-23
- Data Source
  KAKENHI-PROJECT-19591134
[Presentation] Liver-mediated factor IX expression and neutralizing antibody in non-human primates.2008
- Author(s)
  Mizukami H
- Organizer
  The 11^<th> Annual Meeting of American Society of Gene Therapy
- Place of Presentation
  Boston, USA
- Year and Date
  2008-05-29
- Data Source
  KAKENHI-PROJECT-19591134
[Presentation] Inhibitory actions of very low titer neutralizing antibody against AAV8 capsid upon liver-mediated factor IX expression in non-human primates2008
- Author(s)
  Mizukami H, Mimuro J, Ishiwata A, Ono F, Yagi H, Urabe M, Ito T, Kume A, Terao K, Yasutomi Y, Sakata Y, Ozawa K.
- Organizer
  The 14^<th> Annual Meeting of Japan Society of Gene Therapy(Abstract #65)
- Place of Presentation
  Sapporo
- Year and Date
  2008-06-14
- Data Source
  KAKENHI-PROJECT-19591134
[Presentation] Inhibitory actions of very low titer neutralizing antibody against AAV8 capsid upon transgene expression in monkey.2008
- Author(s)
  Mizukami H, Urabe M, Kume A, Ozawa K
- Organizer
  The 67^<th> annual meeting of the Japanese Cancer Association(O-162, Abstract p91)
- Place of Presentation
  Nagoya
- Year and Date
  2008-10-26
- Data Source
  KAKENHI-PROJECT-19591134
[Presentation] Aromatic L-amino acid decarboxylase gene transfer for parkinson's disease: preliminary results of an open-label safety study.2008
- Author(s)
  Muramatsu S, Fujimoto K, Kato S, Mizukami H, Ikeguchi K, Kawakami T, Urabe M, Kume A, Sato T, Watanabe E, Ozawa K, Nakano I.
- Organizer
  The 14^<th> Annual Meeting of Japan Society of Gene Therapy(Abstract #4)
- Place of Presentation
  Sapporo
- Year and Date
  2008-06-12
- Data Source
  KAKENHI-PROJECT-19591134
[Presentation] AAV に対する中和抗体の遺伝子導入に及ぼす影響・カニクイザルにおける検討2008
- Author(s)
  水上浩明、八木洋也、卜部匡司、久米晃啓、小澤敬也
- Organizer
  第56 回日本ウイルス学会学術集会(抄録集p229)
- Place of Presentation
  岡山
- Year and Date
  2008-10-26
- Data Source
  KAKENHI-PROJECT-19591134
[Presentation] AAV vector-mediated systemic interleukin-10 expression ameliorates the metabolic syndrome in Zucker fatty rats.2008
- Author(s)
  Ito T, Nakata M, Uchibori R, Urabe M, Mizukami H, Kume A, Yada T, Shimada K, Ozawa K.
- Organizer
  The 14^<th> Annual Meeting of Japan Society of Gene Therapy(Abstract #32)
- Place of Presentation
  Sapporo
- Year and Date
  2008-06-13
- Data Source
  KAKENHI-PROJECT-19591134
[Presentation] 肝臓を標的とした8型AAVベクターの効果と低力価中和抗体による影響-カニクイザルにおける検討2008
- Author(s)
  水上浩明
- Organizer
  第67回日本癌学会総会
- Place of Presentation
  名古屋
- Year and Date
  2008-10-28
- Data Source
  KAKENHI-PROJECT-17016067
[Presentation] 間葉系幹細胞と造血幹細胞の相互作用の分子メカニズム2008
- Author(s)
  菊池裕二、久米晃啓、卜部匡司、水上浩明、鈴木隆浩、尾崎勝俊、小澤敬也
- Organizer
  第6回幹細胞シンポジウム
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19591134
[Presentation] Liver-mediated factor IX expression be AAV8 vector and pre-existing neutralizing antibody in cynomolgus monkey2008
- Author(s)
  Mizukami, H
- Organizer
  The 16^<th> Annual Congress of the European Society of Gene and Cell Therapy
- Place of Presentation
  Belgium
- Year and Date
  2008-11-15
- Data Source
  KAKENHI-PROJECT-17016067
[Presentation] Full reconstitution of in vivo oxidative activity for phenylalanine in self-complementary AAV vector-treated phenylketonuria mice.2008
- Author(s)
  Kume A, Yagi H, Mizukami H, Urabe M, Ito T, Ozawa, K.
- Organizer
  The 14^<th> Annual Meeting of Japan Society of Gene Therapy(Abstract #70)
- Place of Presentation
  Sapporo
- Year and Date
  2008-06-14
- Data Source
  KAKENHI-PROJECT-19591134
[Presentation] Therapeutic efficacy of AAV vectors encoding sflt-4 against endometrial cancer model with lymph node metastasis.2008
- Author(s)
  Takahashi K, Mizukami H, Saga Y, Takei Y, Urabe M, Kume A, Suzuki M, Ozawa K
- Organizer
  The 67^<th> annual meeting of the Japanese Cancer Association(EW11-2, Abstract p495)
- Place of Presentation
  Nagoya
- Year and Date
  2008-10-28
- Data Source
  KAKENHI-PROJECT-19591134
[Presentation] AAVに対する中和抗体の遺伝子導入に及ぼす影響-カニクイザルにおける検討2008
- Author(s)
  水上浩明
- Organizer
  第56回日本ウイルス学会学術集会
- Place of Presentation
  岡山
- Year and Date
  2008-10-28
- Data Source
  KAKENHI-PROJECT-17016067
[Presentation] Safety of intracranial AAV vector injection in cytomolgus monkeys2007
- Author(s)
  Mizukami, H.
- Organizer
  The 13th Annual Meeting of Japan Society of Gene Therapy
- Place of Presentation
  Nagoya
- Year and Date
  2007-06-28
- Data Source
  KAKENHI-PROJECT-17016067
[Presentation] Production of more potent type 1 adeno-associated virus vectors in insect cells.2007
- Author(s)
  Urabe, M., Mizukami, H., Bakker, A., Kume, A., Hermens, W., Ozawa, K.
- Organizer
  The 13th Annual Meeting of Japan Society of Gene Therapy(Abstract #010)
- Place of Presentation
  Nagoya
- Data Source
  KAKENHI-PROJECT-19591134
[Presentation] Overexpression of PTEN in ovarian cancer cells suppresses peritoneal dissemination and extends survival in mice.2007
- Author(s)
  Takei, Y., Saga, Y., Mizukami, H., Ozawa, K., Suzuki, M.
- Organizer
  The 66th Annual Meeting of the Japanese Cancer Association2007.(Proceedings of the 66th Annual Meeting of the Japanese Cancer Association, p245)
- Place of Presentation
  Yokohama
- Data Source
  KAKENHI-PROJECT-19591134
[Presentation] Sustained expression of prostacyclin synthase by an intramuscular injection of an AAV vector attenuates obesity in Zucker fatty rats.2007
- Author(s)
  Ito, T., Okada, T., Mimuro, J., Nakata, M., Uchibori, R., Urabe, M., Mizukami, H., Kume, A., Sakata, Y., Yada, T., Shimada, K., Ozawa, K.
- Organizer
  The 13th Annual Meeting of Japan Society of Gene Therapy(Abstract #092)
- Place of Presentation
  Nagoya
- Data Source
  KAKENHI-PROJECT-19591134
[Presentation] 血友病B 遺伝子治療の非ヒト霊長類モデルにおける基礎的検討2007
- Author(s)
  石渡彰、三室淳、水上浩明、小野文子、柏倉裕志、大森司、諏合輝子、窓岩清治、寺尾恵治、小澤敬也、坂田洋一
- Organizer
  第69 回日本血液学会総会・第49 回日本臨床血液学会合同総会(抄録集p190)
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19591134
[Presentation] Efficient and stable liver transduction by a self-complementary adeno-associated virus vector for phenylketonuria gene therapy.2007
- Author(s)
  Kume, A., Matsushita, T., Mizukami, H., Urabe, M., Okada T., Ozawa, K.
- Organizer
  The 13th Annual Meeting of Japan Society of Gene Therapy(J Gene Med 10:443-444, 2008)
- Place of Presentation
  Nagoya
- Data Source
  KAKENHI-PROJECT-19591134
[Presentation] Tumor tracking and therapeutic gene amplification by using retroviral vector-producing Mesenchymal stem cells for reinforcement of suicide cancer gene therapy.2007
- Author(s)
  Uchibori, R., Okada, T., Ito, T., Matsushita, T., Urabe, M., Mizukami, H., Kume, A., Ozawa, K.
- Organizer
  The 13th Annual Meeting of Japan Society of Gene Therapy(J Gene Med 10:478-479, 2008)
- Place of Presentation
  Nagoya
- Data Source
  KAKENHI-PROJECT-19591134
[Presentation] Low seropositivity against AAV serotypes 1,8 and 9 in specific pathogen-free cynomolgus monkey colony2007
- Author(s)
  Mizukami H, et. al.
- Organizer
  European Society for Gene and Cell Therapy
- Place of Presentation
  Rotterdam,Netherland
- Year and Date
  2007-10-29
- Data Source
  KAKENHI-PROJECT-19591134
[Presentation] "AAV-mediated gene transfer: current status and future perspectives" The department of Microbiology2007
- Author(s)
  Mizukami, H.
- Organizer
  Molecular Genetics and Immunology Seminar Series
- Place of Presentation
  The University of Kansas Medical Center, Kansas City (USA)
- Year and Date
  2007-05-29
- Data Source
  KAKENHI-PROJECT-19591134
[Presentation] Prevalence of neutralizing antibody against AAV serotypes 1, 8 and 9 in cynomolgus monkey colonies.2007
- Author(s)
  Mizukami, H., Ishiwata, A., Ono, F., Takano, J., Fujimoto, K., Mimuro, J., Urabe, M., Kume, A., Terao, K., Sakata, Y., Ozawa, K.
- Organizer
  The 13th Annual Meeting of Japan Society of Gene Therapy(J Gene Med 10:453, 2008)
- Place of Presentation
  Nagoya
- Data Source
  KAKENHI-PROJECT-19591134
[Presentation] 肝臓特異的にFVIII を高発現するAAV8 ベクターを用いた血友病A マウスへのFVIII 遺伝子導入2007
- Author(s)
  石渡彰、三室淳、柏倉裕志、大森司、諏合輝子、窓岩清治、水上浩明、久米晃啓、小澤敬也、坂田洋一
- Organizer
  第30 回日本血栓止血学会総会(抄録集p462)
- Place of Presentation
  志摩
- Data Source
  KAKENHI-PROJECT-19591134
[Presentation] カニクイザルを用いたAAV ベクターの有効性評価2007
- Author(s)
  水上浩明
- Organizer
  第3回霊長類医科学フォーラム
- Place of Presentation
  つくば
- Year and Date
  2007-12-06
- Data Source
  KAKENHI-PROJECT-19591134
[Presentation] Prevalence of neutralizing antibody against AAV serotypes 1,8 and 9 in cynomolgus monkey colonies.2007
- Author(s)
  Mizukami, H.
- Organizer
  The 13th Annual Meeting of Japan Society of Gene Therapy
- Place of Presentation
  Nagoya
- Year and Date
  2007-06-28
- Data Source
  KAKENHI-PROJECT-17016067
[Presentation] Seropositivity against AAV serotypes 1,8 and 9 in cynomolgus monkey colonies.2007
- Author(s)
  Mizukami, H.
- Organizer
  The 10th Annual Meeting of American Society of Gene Therapy
- Place of Presentation
  Seattle
- Year and Date
  2007-06-02
- Data Source
  KAKENHI-PROJECT-17016067
[Presentation] Safety of intracranial AAV vector injection in cynomolgus monkeys.2007
- Author(s)
  Mizukami, H., Muramatsu, S., Ono, F., Mimuro, J., Sakata, Y., Urabe, M., Kume, A., Tera,o K., Nakano, I., Ozawa, K.
- Organizer
  The 13th Annual Meeting of Japan Society of Gene Therapy(J Gene Med 10:454, 2008)
- Place of Presentation
  Nagoya
- Data Source
  KAKENHI-PROJECT-19591134

1. KANAZAWA Takeharu (20336374)

# of Collaborated Projects: 8 results

# of Collaborated Products: 3 results
2. OZAWA Keiya (30137707)

# of Collaborated Projects: 7 results

# of Collaborated Products: 38 results
3. KUME Akihiro (10264293)

# of Collaborated Projects: 5 results

# of Collaborated Products: 14 results
4. MATSUSHITA Takashi (20343444)

# of Collaborated Projects: 3 results

# of Collaborated Products: 7 results
5. URABE Masashi (40213516)

# of Collaborated Projects: 3 results

# of Collaborated Products: 9 results
6. OKADA Takashi (00326828)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
7. Kusaka Gen (00265258)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
8. MADOIWA Seiji (70296119)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. HIKIJI Hisako (50292876)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. TAKATO Tuyoshi (90171454)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. 佐々木徹 (50332614)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. TSUKAHARA Tomonri (10362120)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. KANAZAWA Hiromi (40570643)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. ICHIMUR Keiichi (00010471)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
15. UEHARA Takayuki (00644402)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
16. HANAZONO Yutaka (70251246)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. SAKATA Yoichi (40129028)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. IWATA Nobuhisa (70246213)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. ISHII Satoshi (10300815)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. KOYAMA Hiroyuki (10241994)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. KATAYAMA Kazunori (00130245)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 三澤清 (90334979)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 間野博行 (90240704)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 小泉敏之 (80323575)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 今吉正一郎 (00570186)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 伊藤真人 (50283106)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 福嶋敬宜 (40384937)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. 吉田栄人 (10296121)

# of Collaborated Projects: 1 results

# of Collaborated Products: 29 results
29. 伊従光洋 (20608351)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
30. 山本祐太朗 (30895446)

# of Collaborated Projects: 1 results

# of Collaborated Products: 28 results
31. 小川良平 (60334736)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
32. 水野哲志 (60882230)

# of Collaborated Projects: 1 results

# of Collaborated Products: 21 results
33. 北山丈二 (20251308)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
34. 山口博紀 (20376445)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
35. 大澤英之 (60458271)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
36. 齋藤心 (60382909)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
37. 宮戸秀世 (90813163)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
38. 金丸理人 (10625544)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
39. 寺谷工 (70373404)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
40. 綿野亮太 (60883915)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
41. 内山拓 (80790724)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
42. 岡田尚已

# of Collaborated Projects: 0 results

# of Collaborated Products: 13 results
43. 坂本明彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

MIZUKAMI Horoaki 水上 浩明

水上 裕明 ミズカミ ヒロアキ

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Development of gene therapy approaches towards hemophilia APrincipal Investigator

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Improvement of neutralizing antibody assay against AAV vectors and application to hemophilia gene therapyPrincipal Investigator

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Tissue specificity and utility of AAV vectors in hemophilia gene therapyPrincipal Investigator

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MIZUKAMI Horoaki 水上浩明

水上裕明ミズカミヒロアキ