Kawazu Masahito 河津正人

… Alternative Names

河津正人カワヅマサヒト

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Researcher Number	20401078
Other IDs
Affiliation (Current)	2025: 千葉県がんセンター(研究所), がん治療開発グループ細胞治療開発研究部, 部長 2025: 国立研究開発法人国立がん研究センター, 研究所, 外来研究員
Affiliation (based on the past Project Information) *help	2021 – 2024: 千葉県がんセンター(研究所), がん治療開発グループ細胞治療開発研究部, 部長 2018 – 2020: 国立研究開発法人国立がん研究センター, 研究所, ユニット長 2017: 東京大学, 大学院医学系研究科(医学部), 特任准教授 2016: 東京大学, 大学院医学系研究科(医学部), 特任講師 2014 – 2015: 東京大学, 医学(系)研究科(研究院), 講師 2007: 東京大学, 医学部・附属病院, 医員 2006: 東京大学, 医学部附属病院, 医員
Review Section/Research Field	Principal Investigator Basic Section 50010:Tumor biology-related / Basic Section 50020:Tumor diagnostics and therapeutics-related / Tumor biology Except Principal Investigator Basic Section 56050:Otorhinolaryngology-related / Basic Section 55020:Digestive surgery-related / Basic Section 49020:Human pathology-related / Basic Section 55010:General surgery and pediatric surgery-related / Basic Section 56040:Obstetrics and gynecology-related / Tumor diagnostics / Biological Sciences
Keywords	Principal Investigator ロングリードシーケンサー / 乳がん / 転写バリアント / 大腸癌 / 全長転写産物解析 / 腫瘍免疫 / 大腸がん / 抗腫瘍免疫 / 子宮頸部上皮内腫瘍 / 免疫チェックポイント阻害剤 … More / 抗原提示 / マイクロサテライト不安定性 / ゲノム構造異常 / ゲノム解析 / トリプルネガティブ乳がん / 染色体構造異常 / 全長RNAシーケンス / 低分子量GTP結合蛋白質 / 低分子量GTP結合タンパク質 / がん遺伝子 … More Except Principal Investigator 腺様嚢胞癌 / メチル化 / 大腸癌 / マイクロサテライト不安定性 / 転写因子 / in situ hybridization / ナノポアシーケンサー / 病理 / 肉腫 / PDXモデル / 癌遺伝子 / 唾液腺癌 / 乳がん / シグナル伝達 / 細胞接着 / 転写バリアント / 子宮体癌 / 卵巣癌 / リキッド・バイオプシー / メチル化判定 / エピゲノム / PDS / 高悪性転化 / シングルセル解析 / 筋上皮 / 上皮 / 早期診断 / RRBS / 潰瘍性大腸炎関連大腸癌 / 潰瘍性大腸炎 / POLE / MLH1メチル化 / MSI-H / 免疫染色 / 大腸がん / リンチ様大腸腫瘍 / MLH1遺伝子メチル化 / リンチ症候群 / AML1 / 転写遺伝子 / 白血病 / 染色体転座 / がん幹細胞 / 白血病発症 Less

Diagnostics of methylation-based predictive biomarkers in ovarian and endometrial carcinomas by using both tumors and liquid biopsy
- Principal Investigator
  
  織田克利
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  The University of Tokyo
難治性乳がんに高発現するTNS3新規転写バリアントの機能解析
- Principal Investigator
  
  盛永敬郎
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Chiba Cancer Center (Research Institute)
患者由来細胞を用いた頭頸部腺様嚢胞癌における遺伝子変異の機能的意義の解明
- Principal Investigator
  
  福本一郎
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Chiba University
新世代in situ hybridization法の確立と多形肉腫の進化過程の解明
- Principal Investigator
  
  牧瀬尚大
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  Chiba Cancer Center (Research Institute)
PDXモデルを用いた腺様嚢胞癌の起源・分化・高悪性化メカニズムの解明
- Principal Investigator
  
  小林謙也
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  The University of Tokyo
Study on the mechanisms of immune evasion in microsatellite instability-high tumorsPrincipal Investigator
- Principal Investigator
  
  Kawazu Masahito
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Chiba Cancer Center (Research Institute)
潰瘍性大腸炎関連癌の早期診断ツールの開発
- Principal Investigator
  
  安西紘幸
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  The University of Tokyo
マイクロサテライト不安定性大腸癌の予後不良化メカニズムの解明
- Principal Investigator
  
  山本陽子
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  The University of Tokyo
Analysis of chromosomal structural variations associated with increased expression of tumor growth factor-alpha in triple-negative breast cancerPrincipal Investigator
- Principal Investigator
  
  Kawazu Masahito
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  National Cancer Center Japan
Genomic and epigenomic analyses of microsatellite instability-high colorectal cancers
- Principal Investigator
  
  Tanaka Toshiaki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor diagnostics
- Research Institution
  The University of Tokyo
Oncogenic mutations of RAC small GTPases in human cancersPrincipal Investigator
- Principal Investigator
  
  Kawazu Masahito
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor biology
- Research Institution
  The University of Tokyo
AML1の機能不全による造血異常と白血病発症機構の解明
- Principal Investigator
  
  黒川峰夫
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo

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All Journal Article Presentation Book

[Book] 第１章－２染色体・ゲノム異常、日本臨床腫瘍学会（編）新臨床腫瘍学（改訂第7版）2024
- Author(s)
  河津正人
- Total Pages
  8
- Publisher
  南江堂
- ISBN
  9784524204267
- Data Source
  KAKENHI-PROJECT-21H02772
[Journal Article] Stem-like progenitor and terminally differentiated TFH-like CD4+ T cell exhaustion in the tumor microenvironment2024
- Author(s)
  Zhou W, Kawashima S, Ishino T, Kawase K, Ueda Y, Yamashita K, Watanabe T, Kawazu M, Dansako H, Suzuki Y, Nishikawa H, Inozume T, Nagasaki J, Togashi Y.
- Journal Title
  
  Cell Reports
  
  Volume: - Issue: 2 Pages: 113797-113797
- DOI
  10.1016/j.celrep.2024.113797
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K14594, KAKENHI-PROJECT-23KK0149, KAKENHI-PROJECT-22K08424, KAKENHI-PROJECT-22K19459, KAKENHI-PROJECT-22K15472, KAKENHI-PROJECT-22K20824, KAKENHI-PROJECT-22H00455, KAKENHI-PROJECT-21H02772
[Journal Article] Deletion of Pak1 in CD11c-Positive Cells Confers Resistance to Mouse Skin Carcinogenesis2024
- Author(s)
  Okumura Kazuhiro、Morinaga Takao、Saito Megumi、Tokunaga Yurika、Otoyama Keisuke、Tanaka Sora、Isogai Eriko、Kawazu Masahito、Togashi Yosuke、Araki Kimi、Wakabayashi Yuichi
- Journal Title
  
  Journal of Investigative Dermatology
  
  Volume: - Issue: 8 Pages: 1890-1893.e5
- DOI
  10.1016/j.jid.2024.01.021
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07012, KAKENHI-PROJECT-22K09247, KAKENHI-PROJECT-23K06512, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-21H02772
[Journal Article] Strategic Approach to Heterogeneity Analysis of Cutaneous Adnexal Carcinomas Using Computational Pathology and Genomics2023
- Author(s)
  Nishimura Yuuki、Ryo Eijitsu、Inoue Satoshi、Kawazu Masahito、Ueno Toshihide、Namikawa Kenjiro、Takahashi Akira、Ogata Dai、Yoshida Akihiko、Yamazaki Naoya、Mano Hiroyuki、Yatabe Yasushi、Mori Taisuke
- Journal Title
  
  JID Innovations
  
  Volume: 3 Issue: 6 Pages: 100229-100229
- DOI
  10.1016/j.xjidi.2023.100229
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K12117, KAKENHI-PROJECT-23K06476, KAKENHI-PROJECT-21H02772, KAKENHI-PROJECT-21H02795, KAKENHI-PROJECT-23K27389
[Journal Article] Somatic mutations can induce a noninflamed tumour microenvironment via their original gene functions, despite deriving neoantigens2023
- Author(s)
  Ishino Takamasa、Kawashima Shusuke、Tanji Etsuko、Ueno Toshihide、Ueda Youki、Ogasawara Sadahisa、Sato Kazuhito、Mano Hiroyuki、Ishihara Soichiro、Kato Naoya、Kawazu Masahito、Togashi Yosuke
- Journal Title
  
  British Journal of Cancer
  
  Volume: 128 Issue: 6 Pages: 1166-1175
- DOI
  10.1038/s41416-023-02165-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08049, KAKENHI-PROJECT-22K19459, KAKENHI-PROJECT-22K15472, KAKENHI-PROJECT-20H03694, KAKENHI-PROJECT-21H02772, KAKENHI-PROJECT-21K20859, KAKENHI-PROJECT-21K12117
[Journal Article] Subclonal accumulation of immune escape mechanisms in microsatellite instability-high colorectal cancers2023
- Author(s)
  Kobayashi Y, Niida A, Nagayama S, Saeki K, （中略）, Mizuno S, Kawazu M, Kohsaka S, Ueno T, Mano H, Ishihara S, Uemura M, Mori M, Doki Y, Eguchi H, Oshima M, Suzuki Y, Shibata T, Mimori K.
- Journal Title
  
  Br J Cancer
  
  Volume: 129 Issue: 7 Pages: 1105-1118
- DOI
  10.1038/s41416-023-02395-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07153, KAKENHI-PROJECT-21K12117, KAKENHI-PROJECT-22K08894, KAKENHI-PROJECT-22K09006, KAKENHI-PROJECT-23K06662, KAKENHI-PROJECT-23K08128, KAKENHI-PROJECT-21K07179, KAKENHI-PROJECT-22H04925, KAKENHI-PROJECT-21H02772, KAKENHI-PROJECT-21H02795, KAKENHI-PROJECT-23K24164
[Journal Article] MSIMEP: Predicting microsatellite instability from microarray DNA methylation tumor profiles2023
- Author(s)
  Santamarina-Garcia M, Brea-Iglesias J, Bramsen JB, Fuentes-Losada M, Caneiro-Gomez FJ, Vazquez-Bueno JA, Lazare-Iglesias H, Fernandez-Diaz N, Sanchez-Rivadulla L, Betancor YZ, Ferreiro-Pantin M, Conesa-Zamora P, Antunez-Lopez JR, Kawazu M, Esteller M, Andersen CL, Tubio JMC, Lopez-Lopez R, Ruiz-Banobre J
- Journal Title
  
  iScience
  
  Volume: 26 Issue: 3 Pages: 106127-106127
- DOI
  10.1016/j.isci.2023.106127
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02772
[Journal Article] High Expression of MHC Class I Overcomes Cancer Immunotherapy Resistance Due to IFNγ Signaling Pathway Defects2023
- Author(s)
  Kawase K、Kawashima S、Nagasaki J、Inozume T、Tanji E、Kawazu M、Hanazawa T、Togashi Y
- Journal Title
  
  Cancer Immunology Research
  
  Volume: In press Issue: 7 Pages: 895-908
- DOI
  10.1158/2326-6066.cir-22-0815
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03694, KAKENHI-PROJECT-23K15261, KAKENHI-PROJECT-22K08424, KAKENHI-PROJECT-21K09625, KAKENHI-PROJECT-22K19459, KAKENHI-PROJECT-22K20824, KAKENHI-PROJECT-21H02772
[Journal Article] Genome Doubling Shapes High-Grade Transformation and Novel EWSR1::LARP4 Fusion Shows SOX10 Immunostaining in Hyalinizing Clear Cell Carcinoma of Salivary Gland2023
- Author(s)
  Kobayashi Kenya、Kawazu Masahito、Yoshimoto Seiichi、Ueno Toshihide、Omura Go、Saito Yuki、Ando Mizuo、Ryo Eigitsu、Sakyo Airi、Yoshida Akihiko、Yatabe Yasushi、Mano Hiroyuki、Mori Taisuke
- Journal Title
  
  Laboratory Investigation
  
  Volume: 103 Issue: 10 Pages: 100213-100213
- DOI
  10.1016/j.labinv.2023.100213
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K12117, KAKENHI-PROJECT-22K09662, KAKENHI-PROJECT-23K06476, KAKENHI-PROJECT-21K09556, KAKENHI-PROJECT-21H02772, KAKENHI-PROJECT-21H02795, KAKENHI-PROJECT-23K27389
[Journal Article] Application of organoid culture from HPV18-positive small cell carcinoma of the uterine cervix for precision medicine2023
- Author(s)
  Kusakabe M, Taguchi A, Tanikawa M, Hoshi D, Tsuchimochi S, Qian X, Toyohara Y, Kawata A, Wagatsuma R, Yamaguchi K, Yamamoto Y, Ikemura M, Sone K, Mori-Uchino M, Matsunaga H, Tsuruga T, Nagamatsu T, Kukimoto I, Wada-Hiraike O, Kawazu M, Ushiku T, Takeyama H, Oda K, Kawana K, Hippo Y, Osuga Y.
- Journal Title
  
  Cancer Med
  
  Volume: 12 Issue: 7 Pages: 8476-8489
- DOI
  10.1002/cam4.5588
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09682, KAKENHI-PROJECT-21K08019, KAKENHI-PROJECT-22K16853, KAKENHI-PROJECT-21H02772, KAKENHI-PROJECT-20K09662, KAKENHI-PROJECT-23K08814
[Journal Article] Immunologic Significance of CD80/CD86 or Major Histocompatibility Complex-II Expression in Thymic Epithelial Tumors2023
- Author(s)
  Ikeda Hideki、Nagasaki Joji、Shimizu Daiki、Katsuya Yuki、Horinouchi Hidehito、Hosomi Yukio、Tanji Etsuko、Iwata Takekazu、Itami Makiko、Kawazu Masahito、Ohe Yuichiro、Suzuki Takuji、Togashi Yosuke
- Journal Title
  
  JTO Clinical and Research Reports
  
  Volume: 4 Issue: 10 Pages: 100573-100573
- DOI
  10.1016/j.jtocrr.2023.100573
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19459, KAKENHI-PROJECT-22K20824, KAKENHI-PROJECT-21H02772
[Journal Article] MYC/glutamine dependency is a therapeutic vulnerability in pancreatic cancer with deoxycytidine kinase inactivation-induced gemcitabine resistance2023
- Author(s)
  Dash Suman, Ueda Takeshi, Komuro Akiyoshi, Amano Hisayuki, Honda Masahiko, Kawazu Masahito, Okada Hitoshi.
- Journal Title
  
  Molecular Cancer Research
  
  Volume: online publication Issue: 5 Pages: 444-457
- DOI
  10.1158/1541-7786.mcr-22-0554
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06829, KAKENHI-PROJECT-22K11513, KAKENHI-PROJECT-21H02772, KAKENHI-PROJECT-20K07346, KAKENHI-PROJECT-21K07135
[Journal Article] HLA Class I Analysis Provides Insight Into the Genetic and Epigenetic Background of Immune Evasion in Colorectal Cancer With High Microsatellite Instability2022
- Author(s)
  Kawazu M, Ueno T, Saeki K, Sax N, Togashi Y, Kanaseki T, Chida K, Kishigami F, Sato K, Kojima S, Tanegashima T, Matsubara D, Tane K, Tanaka Y, Iinuma H, Hashiguchi Y, Hazama S, Khor SS, Tokunaga K, Tsuboi M, Niki T, Eto M, Shitara K, Torigoe T, Ishihara S, Aburatani H, Haeno H, Nishikawa H, Mano H
- Journal Title
  
  Gastroenterology
  
  Volume: 162 Issue: 3 Pages: 799-812
- DOI
  10.1053/j.gastro.2021.10.010
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H06162, KAKENHI-PROJECT-20H03694, KAKENHI-PROJECT-21H02772, KAKENHI-PROJECT-20K08531, KAKENHI-PROJECT-21K12117, KAKENHI-PROJECT-21K18257, KAKENHI-PROJECT-17K10655
[Journal Article] Mixed Response to Cancer Immunotherapy is Driven by Intratumor Heterogeneity and Differential Interlesion Immune Infiltration2022
- Author(s)
  T. Morinaga, T. Inozume, Y. Togashi et al.
- Journal Title
  
  Cancer Research Communications
  
  Volume: 2 Issue: 7 Pages: 739-753
- DOI
  10.1158/2767-9764.crc-22-0050
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08314, KAKENHI-PROJECT-21K12117, KAKENHI-PROJECT-22K08424, KAKENHI-PROJECT-22K19459, KAKENHI-PROJECT-20H03694, KAKENHI-PROJECT-21H02772
[Journal Article] Transcriptomic Profiling of MSI-H/dMMR Gastrointestinal Tumors to Identify Determinants of Responsiveness to Anti?PD-1 Therapy2022
- Author(s)
  Chida K、Kawazoe A、Suzuki T、Kawazu M、Ueno T、Takenouchi K、Nakamura Y、Kuboki Y、Kotani D、Kojima T、Bando H、Mishima S、Kuwata T、Sakamoto N、Watanabe J、Mano H、Ikeda M、Shitara K、Endo I、Nakatsura T、Yoshino T
- Journal Title
  
  Clinical Cancer Research
  
  Volume: 28 Issue: 10 Pages: 2110-2117
- DOI
  10.1158/1078-0432.ccr-22-0041
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K12117, KAKENHI-PROJECT-21H02772
[Journal Article] HSP90 inhibition overcomes resistance to molecular targeted therapy in BRAFV600E mutant high-grade glioma2022
- Author(s)
  Sasame J, Ikegaya N, Kawazu M, Natsumeda M, Hayashi T, Isoda M, Satomi K, Tomiyama A, Oshima A, Honma H, Miyake Y, Takabayashi K, Nakamura T, Ueno T, Matsushita Y, Iwashita H, Kanemaru Y, Murata H, Ryo A, Terashima K, Yamanaka S, Fujii Y, Mano H, Komori T, Ichimura K, Cahill DP, Wakimoto H, Yamamoto T, Tateishi K.
- Journal Title
  
  Clin Cancer Res
  
  Volume: 印刷中 Issue: 11 Pages: 2425-2439
- DOI
  10.1158/1078-0432.ccr-21-3622
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10888, KAKENHI-PROJECT-19K09476, KAKENHI-PROJECT-19K09488, KAKENHI-PROJECT-19H03774, KAKENHI-PROJECT-21K09156, KAKENHI-PROJECT-22K06951, KAKENHI-PROJECT-22K09210, KAKENHI-PROJECT-21H02772, KAKENHI-PROJECT-21H03042
[Journal Article] Exploration of predictive biomarkers for postoperative recurrence of stage II/III colorectal cancer using genomic sequencing2022
- Author(s)
  Kishigami Fumishi、Tanaka Yosuke、Yamamoto Yoko、Ueno Toshihide、Kojima Shinya、Sato Kazuhito、Inoue Satoshi、Sugaya Saori、Ishihara Soichiro、Mano Hiroyuki、Kawazu Masahito
- Journal Title
  
  Cancer Medicine
  
  Volume: 11 Issue: 18 Pages: 3457-3470
- DOI
  10.1002/cam4.4710
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K12117, KAKENHI-PROJECT-21H02772
[Journal Article] Cells with stem‐like properties are associated with the development of HPV18‐positive cervical cancer2022
- Author(s)
  Kusakabe Misako、Wada‐Hiraike Osamu(16)、Kawazu Masahito、Ushiku Tetsuo、Takeyama Haruko、Oda Katsutoshi、Kawana Kei、Mano Hiroyuki、Osuga Yutaka
- Journal Title
  
  Cancer Science
  
  Volume: 114 Issue: 3 Pages: 885-895
- DOI
  10.1111/cas.15664
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09489, KAKENHI-PROJECT-21K09553, KAKENHI-PROJECT-22K16853, KAKENHI-PROJECT-21H02772, KAKENHI-PROJECT-20K09662, KAKENHI-PROJECT-20K18157, KAKENHI-PROJECT-21H03074
[Journal Article] Two novel high-risk adult B-cell acute lymphoblastic leukemia subtypes with high expression of CDX2and IDH1/2 mutations2022
- Author(s)
  Yasuda Takahiko、Ogawa Seishi, et al.
- Journal Title
  
  Blood
  
  Volume: 139 Issue: 12 Pages: 1850-1862
- DOI
  10.1182/blood.2021011921
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H05656, KAKENHI-PROJECT-21H02772, KAKENHI-PROJECT-20K08723, KAKENHI-PROJECT-21K19505, KAKENHI-PROJECT-21K08384, KAKENHI-PROJECT-22K08490
[Journal Article] TIGIT/CD155 axis mediates resistance to immunotherapy in patients with melanoma with the inflamed tumor microenvironment2021
- Author(s)
  Kawashima S, Inozume T, Kawazu M, Ueno T, Nagasaki J, Tanji E, Honobe A, Ohnuma T, Kawamura T, Umeda Y, Nakamura Y, Kawasaki T, Kiniwa Y, Yamasaki O, Fukushima S, Ikehara Y, Mano H, Suzuki Y, Nishikawa H, Matsue H, Togashi Y.
- Journal Title
  
  Journal for ImmunoTherapy of Cancer
  
  Volume: 9 Issue: 11 Pages: e003134-e003134
- DOI
  10.1136/jitc-2021-003134
- NAID
  120007175403
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07682, KAKENHI-PROJECT-19K08744, KAKENHI-PROJECT-17H06162, KAKENHI-PROJECT-19H05650, KAKENHI-PROJECT-20H03694, KAKENHI-PROJECT-21H02772, KAKENHI-PROJECT-20K08652, KAKENHI-PROJECT-21K06910, KAKENHI-PROJECT-21K08351, KAKENHI-PROJECT-21K12117
[Journal Article] A Low Tumor Mutational Burden and <i>PTEN</i> Mutations Are Predictors of a Negative Response to PD-1 Blockade in MSI-H/dMMR Gastrointestinal Tumors2021
- Author(s)
  Chida Keigo, Kawazoe Akihito, Kawazu Masahito et al.
- Journal Title
  
  Clinical Cancer Research
  
  Volume: 27 Issue: 13 Pages: 3714-3724
- DOI
  10.1158/1078-0432.ccr-21-0401
- NAID
  130008144997
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02772, KAKENHI-PROJECT-21K12117
[Journal Article] Multicenter Phase I/II Trial of Napabucasin and Pembrolizumab in Patients with Metastatic Colorectal Cancer (EPOC1503/SCOOP Trial)2020
- Author(s)
  Kawazoe Akihito、Kuboki Yasutoshi、Shinozaki Eiji、Hara Hiroki、Nishina Tomohiro、Komatsu Yoshito、Yuki Satoshi、Wakabayashi Masashi、Nomura Shogo、Sato Akihiro、Kuwata Takeshi、Kawazu Masahito、Mano Hiroyuki、Togashi Yosuke、Nishikawa Hiroyoshi、Yoshino Takayuki
- Journal Title
  
  Clinical Cancer Research
  
  Volume: 26 Issue: 22 Pages: 5887-5894
- DOI
  10.1158/1078-0432.ccr-20-1803
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03694, KAKENHI-PROJECT-18K07320, KAKENHI-PROJECT-19K22574, KAKENHI-PROJECT-17H06162
[Journal Article] KRAS mutations in uterine endometrium are associated with gravidity and parity.2020
- Author(s)
  Inoue, S., Yoshida, E., Fukui, Y., Ueno, T., Kawazu, M., Takeyama, R., Ikemura, M., Osuga, Y., Terao, Y., Hirota, Y., Mano, H.
- Journal Title
  
  Cell Death Disease
  
  Volume: 11 Issue: 5 Pages: 347-347
- DOI
  10.1038/s41419-020-2559-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07708, KAKENHI-PROJECT-19H03796, KAKENHI-PROJECT-18K07320, KAKENHI-PROJECT-19H03144
[Journal Article] An Oncogenic Alteration Creates a Microenvironment that Promotes Tumor Progression by Conferring a Metabolic Advantage to Regulatory T Cells2020
- Author(s)
  Shogo Kumagai, Yosuke Togashi, Chika Sakai, Akihito Kawazoe, Masahito Kawazu, Toshihide Ueno, Eiichi Sato, Takeshi Kuwata, Takahiro Kinoshita, Masami Yamamoto, Sachiyo Nomura, Tetsuya Tsukamoto, Hiroyuki Mano, Kohei Shitara, Hiroyoshi Nishikawa
- Journal Title
  
  Immunity
  
  Volume: 14 Issue: 1 Pages: 187-203
- DOI
  10.1016/j.immuni.2020.06.016
- NAID
  120006952281
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06408, KAKENHI-PROJECT-19H03729, KAKENHI-PROJECT-20H03694, KAKENHI-PROJECT-18J21551, KAKENHI-PROJECT-18K07320, KAKENHI-PROJECT-19K22574, KAKENHI-PROJECT-17H06162
[Journal Article] A Hyperactive RelA/p65-Hexokinase 2 Signaling Axis Drives Primary Central Nervous System Lymphoma2020
- Author(s)
  Tateishi Kensuke、Miyake Yohei、Kawazu Masahito、Sasaki Nobuyoshi、Nakamura Taishi、Sasame Jo、Yoshii Yukie、Ueno Toshihide、Miyake Akio、Matsushita Yuko、Shiba Norio、Udaka Naoko、Ohki Kentaro、Fink Alexandria L.、Tummala Shilpa S.、Natsumeda Manabu、Miller Julie J.、Fujii Yukihiko、et al
- Journal Title
  
  Cancer Research
  
  Volume: 80 Issue: 23 Pages: 5330-5343
- DOI
  10.1158/0008-5472.can-20-2425
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10888, KAKENHI-PROJECT-19K08350, KAKENHI-PROJECT-19K09476, KAKENHI-PROJECT-19K09488, KAKENHI-PROJECT-19K18398, KAKENHI-PROJECT-17K10057, KAKENHI-PROJECT-18K07320, KAKENHI-PROJECT-18K08950, KAKENHI-PROJECT-18K09000, KAKENHI-PROJECT-19H03774
[Journal Article] Uterine adenomyosis is an oligoclonal disorder associated with KRAS mutations2019
- Author(s)
  Inoue Satoshi、Hirota Yasushi、Ueno Toshihide、十人省略、Tanaka Yosuke、Sakata Seiji、Takeuchi Kengo、Muraoka Ayako、Osuka Satoko、Saito Tsuyoshi、Oda Katsutoshi、Osuga Yutaka、Terao Yasuhisa、Kawazu Masahito、Mano Hiroyuki
- Journal Title
  
  Nature Communications
  
  Volume: 10 Issue: 1 Pages: 1-13
- DOI
  10.1038/s41467-019-13708-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07320, KAKENHI-PROJECT-18K09249, KAKENHI-PROJECT-19K07708, KAKENHI-PROJECT-19H03796, KAKENHI-PROJECT-17K07250, KAKENHI-PROJECT-18K19601, KAKENHI-PROJECT-18K16757, KAKENHI-PROJECT-16H04679, KAKENHI-PROJECT-16H05469, KAKENHI-PROJECT-19H03144, KAKENHI-PROJECT-19K22670
[Journal Article] Differential regulation of CpG island methylation within divergent and unidirectional promoters in colorectal cancer2019
- Author(s)
  Namba Shinichi、Sato Kazuhito、Kojima Shinya、Ueno Toshihide、Yamamoto Yoko、Tanaka Yosuke、Inoue Satoshi、Nagae Genta、Iinuma Hisae、Hazama Shoichi、Ishihara Soichiro、Aburatani Hiroyuki、Mano Hiroyuki、Kawazu Masahito
- Journal Title
  
  Cancer Science
  
  Volume: 110 Issue: 3 Pages: 1096-1104
- DOI
  10.1111/cas.13937
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07250, KAKENHI-PROJECT-18K07963, KAKENHI-PROJECT-18K08716, KAKENHI-PROJECT-17J00386, KAKENHI-PROJECT-15K08987, KAKENHI-PROJECT-16K07143, KAKENHI-PROJECT-18K07320, KAKENHI-PROJECT-19K07708
[Journal Article] A germline HLTF mutation in familial MDS induces DNA damage accumulation through impaired PCNA polyubiquitination2019
- Author(s)
  Takaoka Kensuke、Kawazu Masahito、Koya Junji、Yoshimi Akihide、Masamoto Yosuke、Maki Hiroaki、Toya Takashi、Kobayashi Takashi、Nannya Yasuhito、Arai Shunya、Ueno Toshihide、Ueno Hironori、Suzuki Kenshi、Harada Hironori、Manabe Atsushi、Hayashi Yasuhide、Mano Hiroyuki、Kurokawa Mineo
- Journal Title
  
  Leukemia
  
  Volume: 印刷中 Issue: 7 Pages: 1773-1782
- DOI
  10.1038/s41375-019-0385-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K07250, KAKENHI-PROJECT-17K10130, KAKENHI-PROJECT-18K16110, KAKENHI-PROJECT-18H04052, KAKENHI-PROJECT-16K09831, KAKENHI-PROJECT-17K16181, KAKENHI-PROJECT-18K07320
[Journal Article] Fusion Kinases Identified by Genomic Analyses of Sporadic Microsatellite Instability?High Colorectal Cancers2018
- Author(s)
  Sato Kazuhito、Kawazu Masahito、Yamamoto Yoko、Ueno Toshihide、Kojima Shinya、Nagae Genta、Abe Hiroyuki、Soda Manabu、Oga Takafumi、Kohsaka Shinji、Sai Eirin、Yamashita Yoshihiro、Iinuma Hisae、Fukayama Masashi、Aburatani Hiroyuki、Watanabe Toshiaki、Mano Hiroyuki
- Journal Title
  
  Clinical Cancer Research
  
  Volume: 25 Issue: 1 Pages: 378-389
- DOI
  10.1158/1078-0432.ccr-18-1574
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K07250, KAKENHI-PROJECT-18K07963, KAKENHI-PROJECT-18K08716, KAKENHI-PROJECT-17J00386, KAKENHI-PROJECT-15K08987, KAKENHI-PROJECT-16K07143
[Journal Article] Transforming somatic mutations of mammalian target of rapamycin kinase in human cancer.2015
- Author(s)
  Yamaguchi H, Kawazu M, Yasuda T, Soda M, Ueno T, Kojima S, Yashiro M, Yoshino I, Ishikawa Y, Sai E, Mano H.
- Journal Title
  
  Cancer Sci.
  
  Volume: 106 Issue: 12 Pages: 1687-92
- DOI
  10.1111/cas.12828
- NAID
  120006987669
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26430106, KAKENHI-PROJECT-26461155
[Journal Article] Oncogenic activity of BIRC2 and BIRC3 mutants independent of nuclear factor-κB-activating potential.2015
- Author(s)
  Yamato A, Soda M, Ueno T, Kojima S, Sonehara K, Kawazu M, Sai E, Yamashita Y, Nagase T, Mano H.
- Journal Title
  
  Cancer Sci.
  
  Volume: 106 Issue: 9 Pages: 1137-42
- DOI
  10.1111/cas.12726
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26430106, KAKENHI-PROJECT-26461155, KAKENHI-PROJECT-23249045
[Journal Article] Evi-1 promotes para-aortic splanchnopleural hematopoiesis through up-regulation of GATA-2 and repression of TGF-β signaling.2008
- Author(s)
  Sato T, Goyama S, Nitta E, Takeshita M, Yoshimi M, Nakagawa M, Nakagwa M, Kawazu M, Ichikawa M, and Kurokawa M.
- Journal Title
  
  Cancer Science
- NAID
  10024008671
- Data Source
  KAKENHI-PROJECT-18013014
[Journal Article] AML1/Runx1 negatively regulates quiescent hematopoietic stem cells in adult hematopoiesis.2008
- Author(s)
  Ichikawa M, Goyama S, Asai T, Kawazu M, Nakagawa M, Takeshita M, Chiba S, Ogawa S, and Kurokawa M.
- Journal Title
  
  The Journal of Immunology 180
  
  Pages: 4402-4408
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18013014
[Journal Article] Expression profiling of immature thymocytes revealed a novel homebox gene that regulates double-negative thymocyte development.2007
- Author(s)
  Kawazu M, Yamamoto G, Yoshimi M, Yamamoto K, Asai T, Ichikawa M, Seo S, Nakagawa M, Chiba S, Kurokawa M, Ogawa S.
- Journal Title
  
  The Journal of Immunology 179
  
  Pages: 5445-5345
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18013014
[Journal Article] AML1/Runx1 rescues Notchl-Null mutation-induced deficiency of para-aortic splanchnopleural hematopoiesis of para-aortic splanchnopleural hematopoiesis.2006
- Author(s)
  Nakagawa M, Ichikawa M, Kumano K, Coyama S, Kawazu M, Asai T, Ogawa S, Kurokawa M, Chiba S.
- Journal Title
  
  Blood 15
  
  Pages: 3329-3334
- Data Source
  KAKENHI-PROJECT-18013014
[Presentation] EWSR1/DDIT3の複雑な再構成をナノポアシーケンサーで同定した粘液型脂肪肉腫の一例2024
- Author(s)
  牧瀬尚大, リンジェイソン, 影山肇, 竹田直生, 及川麻理子, 杉山孝弘, 川名秀忠, 荒木章伸, 河津正人, 伊丹真紀子
- Organizer
  第113回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-23K06438
[Presentation] High major histocompatibility complex class I expression overcomes cancer immunotherapy resistance due to interferon gamma signaling pathway defects2023
- Author(s)
  Kawase K, Kawashima S, Nagasaki J, Inozume T, Yamamoto H, Kawazu M, Hanazawa T, Togashi Y
- Organizer
  AACR annual meeting 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02772
[Presentation] ロングリードシーケンサーを用いたがん関連転写バリアントの探索2023
- Author(s)
  河津正人、盛永敬郎、リンジェイソン
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21H02772
[Presentation] Loss of pathological biphasic structure is a poor prognostic factor in adenoid cystic carcinoma.2023
- Author(s)
  Kenya Kobayashi, Taisuke Mori, Suguru Miyata, Toyoyuki Hanazawa, Yuki Saito, Mizuo Ando, Masahito Kawazu
- Organizer
  日本癌学会
- Data Source
  KAKENHI-PROJECT-22K09662
[Presentation] 唾液腺明細胞癌のゲノム解析 High-grade transformationとEWSR1-LARP4融合遺伝子の同定2022
- Author(s)
  小林謙也、河津正人、齊藤祐毅、吉本世一、森泰昌
- Organizer
  第66回日本唾液腺学会
- Data Source
  KAKENHI-PROJECT-22K09662
[Presentation] High Resolution HLA Typing allows insight into Immune Evasion in Colon Cancer2022
- Author(s)
  河津正人
- Organizer
  PacBio Asia Pacific Webinar Series
- Invited
- Data Source
  KAKENHI-PROJECT-21H02772
[Presentation] マイクロサテライト不安定性大腸癌における抗原提示機能障害2022
- Author(s)
  河津正人
- Organizer
  第81回日本癌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-21H02772
[Presentation] Genomic analysis of hyalinized clear cell carcinoma High-grade transformation and novel EWSR1-LARP4 fusion2022
- Author(s)
  Kenya Kobayashi, Masahito Kawazu, Taisuke Mori
- Organizer
  The 81 the Annual Meeting of the Japanese Cancer Association
- Data Source
  KAKENHI-PROJECT-22K09662
[Presentation] 乳癌におけるTNS3バリアント発現差の同定と解析2022
- Author(s)
  盛永敬郎、リンジェイソン、河津正人
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21H02772
[Presentation] 免疫学的分類によるマイクロサテライト高度不安定性大腸がんの免疫回避機構の解明2021
- Author(s)
  河津正人、岸上史士、波江野洋、石原聡一郎、間野博行
- Organizer
  第18回日本臨床腫瘍学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-18K07320
[Presentation] Full-length Transcriptome Analysis of Breast Cancer with Iso-Seq2021
- Author(s)
  河津正人
- Organizer
  PacBio Virtual User Meeting
- Invited
- Data Source
  KAKENHI-PROJECT-21H02772
[Presentation] マイクロサテライト不安定性大腸がんの抗原提示機能障害の評価方法2021
- Author(s)
  河津正人
- Organizer
  第34回日本バイオセラピィ学会学術集会総会
- Invited
- Data Source
  KAKENHI-PROJECT-21H02772
[Presentation] 全長RNAシーケンスの複数検体統合解析手法の開発と乳がん22検体への応用2020
- Author(s)
  難波真一、上野敏秀、間野博行、河津正人
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K07320
[Presentation] クラスI HLA変異に基づいたマイクロサテライト高度不安定性大腸がんの免疫学的状態の分類2020
- Author(s)
  河津正人、岸上史士、波江野洋、石原聡一郎、西川博嘉、間野博行
- Organizer
  第24回日本がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-18K07320
[Presentation] マイクロサテライト高度不安定性大腸がんにおけるクラスI HLA変異解析と免疫学的状態の分類2020
- Author(s)
  河津正人、岸上史士、上野敏秀、波江野洋、石原聡一郎、西川博嘉、間野博行
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K07320
[Presentation] トリプルネガティブ乳がんにおけるゲノム構造異常の解析2018
- Author(s)
  河津正人
- Organizer
  ゲノムテクノロジー第164委員会　第56回研究会
- Data Source
  KAKENHI-PROJECT-18K07320
[Presentation] 癌cDNA全長シーケンス解析手法の開発と乳がんへの応用2018
- Author(s)
  難波真一、河津正人、上野敏秀、間野博行
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K07320

1. 石原聡一郎 (00376443)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. 山本陽子 (30376644)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. 小林謙也 (80648311)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
4. Tanaka Toshiaki (30647540)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 黒川峰夫 (80312320)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
6. 渡邉聡明 (80210920)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 山口博紀 (20376445)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 野澤宏彰 (80529173)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 川合一茂 (80571942)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 畑啓介 (60526755)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 川添彬人 (20754675)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. 波江野洋 (70706754)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 坂下信悟 (40620638)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 安西紘幸 (60897180)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 森泰昌 (00296708)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
16. 織田克利 (30359608)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 田口歩 (60756782)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 曾根献文 (90598872)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 盛永敬郎 (30757000)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
20. 羽山晶子 (80758251)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 福本一郎 (70748764)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 花澤豊行 (90272327)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 牧瀬尚大 (70815373)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
24. LIN JASON (80774124)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
25. MIZUNO Shinichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. FUJII Yukihiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
27. HIRAIKE Osamu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. YAMAMOTO Masami

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. OKUMURA Kazuhiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
30. 西川博嘉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
31. 上野敏秀

# of Collaborated Projects: 0 results

# of Collaborated Products: 7 results
32. 猪爪隆史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
33. 冨樫庸介

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
34. 小笠原定久

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
35. 長崎譲慈

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
36. 井上聡

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
37. 小川誠司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
38. 池原譲

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
39. 柊元巌

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
40. 若林雄一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
41. 古室暁義

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kawazu Masahito 河津 正人

河津 正人 カワヅ マサヒト

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Study on the mechanisms of immune evasion in microsatellite instability-high tumorsPrincipal Investigator

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Analysis of chromosomal structural variations associated with increased expression of tumor growth factor-alpha in triple-negative breast cancerPrincipal Investigator

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Oncogenic mutations of RAC small GTPases in human cancersPrincipal Investigator

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[Book] 第１章－２ 染色体・ゲノム異常、日本臨床腫瘍学会（編）新臨床腫瘍学（改訂第7版）2024

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[Journal Article] Stem-like progenitor and terminally differentiated TFH-like CD4+ T cell exhaustion in the tumor microenvironment2024

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[Journal Article] Deletion of Pak1 in CD11c-Positive Cells Confers Resistance to Mouse Skin Carcinogenesis2024

Kawazu Masahito 河津正人

河津正人カワヅマサヒト

[Book] 第１章－２染色体・ゲノム異常、日本臨床腫瘍学会（編）新臨床腫瘍学（改訂第7版）2024