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Yachide Tomomi  谷内出 友美

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… Alternative Names

YACHIDE Tomomi  谷内出 友美

NOGUCHI Tomomi  谷内出 友美

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Researcher Number 20401284
Other IDs
Affiliation (Current) 2025: 東京大学, 定量生命科学研究所, 准教授
Affiliation (based on the past Project Information) *help 2019 – 2020: 東京大学, 定量生命科学研究所, 准教授
2018: 東京大学, 定量生命科学研究所, 講師
2017: 東京大学, 分子細胞生物学研究所, 講師
2015 – 2016: 東京大学, 分子細胞生物学研究所, 助教
2012 – 2013: 東京大学, 分子細胞生物学研究所, 技術職員 … More
2011: 東京大学, 分子細胞生物研究所, 技術職員
2010: The University of Tokyo, 分子細胞生物学研究所, その他
2006 – 2009: 東京大学, 分子細胞生物学研究所, 技術職員 Less
Review Section/Research Field
Principal Investigator
Drug development chemistry / Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
Except Principal Investigator
Drug development chemistry / Biological Sciences
Keywords
Principal Investigator
構造活性相関 / 構造展開 / 核内受容体 / サリドマイド / 医薬品探索 / ブロモドメイン / エピジェネティクス / エストロゲン受容体 / シクロオキシゲナーゼ / 血管新生 … More / チューブリン / α-グルコシダーゼ / 創薬化学 / 薬学 / 分解誘導 / 転写因子 / SERD / タンパク質分解誘導 / BETファミリータンパク質 / myc / 翻訳後修飾 / HDAC / 多重薬理 / ポリファーマコロジー / 分化誘導 / 糖尿病 / グリコーゲンホスホリラーゼ / ペルオキシソーム増殖剤応答性受容体 / 肝臓X受容体 / ピューロマイシン感受性アミノペプチダーゼ / ヒダントイン誘導体 / 肝臓X受容体 / マルチテンプレート / ケミカルバイオロジー / 活性評価 / 血管新生阻害 / チューブリン重合阻害 / 腫瘍壊死因子(TNF)-α / 細胞増殖阻害 / LiverX受容体(LXR) / 代謝物 / 細胞分化 / 生物活性物質 … More
Except Principal Investigator
核内受容体リガンド / 生理活性物質 / 核内受容体 / 構造展開 / マルチテンプレート / 酵素阻害剤 / 抗アンドロゲン / 阻害剤 / サリドマイド / 構造活性相関 / 薬理シャペロン / 分子設計 / ケイ素 / ブロモドメイン / ハンチンチン / プロテインノックダウン / 多重薬理 / 変異ロドプシン / 網膜色素変性症 / ニーマン・ピック病C型 / 膜タンパク質 / 蛋白質相互作用 / 蛋白変性症 / フォールディング異常症 / トラフィッキング / PPAR / ジフェニルペンタン / 肝臓X受容体 / 生物応答調節 / 化合部物ライブラリー / ケミカルジェネティクス / 抗ウイルス剤 / ロドプシン / 細胞内局在 / テンプレート / フォールディング / 生物応答調節剤創製法 / 医薬分子機能学 / ビタミンD / チュブリン重合阻害 / 代謝物 / レチノイド / ヒストン脱アセチル化酵素 / 血管新生阻害 / ペプチダーゼ / 分化誘導 / チュブリン重合阻害剤 / アポトーシス / がん治療 Less
  • Research Projects

    (8 results)
  • Research Products

    (147 results)
  • Co-Researchers

    (10 People)
  •  Therapeutic strategy based on the direct degradation of disease-related proteinsPrincipal Investigator

    • Principal Investigator
      Yachide Tomomi
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
    • Research Institution
      The University of Tokyo
  •  Application of the multi-template approach for the development of polypharmacological agentsPrincipal Investigator

    • Principal Investigator
      Yachide Tomomi
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Drug development chemistry
    • Research Institution
      The University of Tokyo
  •  Polypharmacology based on dynamism of the target protein

    • Principal Investigator
      Hashimoto Yuichi
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Drug development chemistry
    • Research Institution
      The University of Tokyo
  •  Chemical control of protein dramatype

    • Principal Investigator
      HASHIMOTO Yuichi
    • Project Period (FY)
      2010 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Drug development chemistry
    • Research Institution
      The University of Tokyo
  •  Multi-functionality and structure development of thalidomidePrincipal Investigator

    • Principal Investigator
      YACHIDE Tomomi
    • Project Period (FY)
      2009 – 2012
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Drug development chemistry
    • Research Institution
      The University of Tokyo
  •  Biological response modification based on multi-template and dramatype approaches.

    • Principal Investigator
      HASHIMOTO Yuichi
    • Project Period (FY)
      2007 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Drug development chemistry
    • Research Institution
      The University of Tokyo
  •  Thalidomide as a cell differentiation regulatorPrincipal Investigator

    • Principal Investigator
      NOGUCHI Tomomi
    • Project Period (FY)
      2006 – 2008
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Drug development chemistry
    • Research Institution
      The University of Tokyo
  •  Development of anti-tumor agents based on biological response modification.

    • Principal Investigator
      HASHIMOTO Yuichi
    • Project Period (FY)
      2005 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo

All 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005

All Journal Article Presentation Book

  • [Book] Pharmacoepigenetics -Translation Epigenetics Series- Volume 102019

    • Author(s)
      Tomomi Noguchi-Yachide(edited by Ramon Cacabelos)
    • Total Pages
      11
    • Publisher
      Academic Press
    • ISBN
      9780128139394
    • Data Source
      KAKENHI-PROJECT-18K06570
  • [Journal Article] Structure-activity relationship study of estrogen receptor down-regulators with a diphenylmethane skeleton2019

    • Author(s)
      Nanjyo Shun、Ohgane Kenji、Yoshioka Hiromasa、Makishima Makoto、Hashimoto Yuichi、Noguchi- Yachide Tomomi
    • Journal Title

      Bioorganic & Medicinal Chemistry

      Volume: 27 Issue: 10 Pages: 1952-1961

    • DOI

      10.1016/j.bmc.2019.03.042

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K06570, KAKENHI-PROJECT-17H03996, KAKENHI-PROJECT-17K15487
  • [Journal Article] Unexpected Emergence of Luciferase-Inhibitory Activity During Structural Development Study of Phenyloxadiazole-based Ppar Ligands2018

    • Author(s)
      Ryuta Shioi, Yosuke Toyota, Tomomi Noguchi-Yachide, Minoru Ishikawa, Takao Yamaguchi, Makoto Makishima, Yuichi Hashimoto, and Kenji Ohgane
    • Journal Title

      HETEROCYCLES

      Volume: 97 Issue: 2 Pages: 854-864

    • DOI

      10.3987/com-18-s(t)61

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K15487, KAKENHI-PROJECT-18K06570
  • [Journal Article] Design and synthesis of estrogen receptor ligands with a 4-heterocycle-4-phenylheptane skeleton2018

    • Author(s)
      Eto Ryo、Misawa Takashi、Noguchi-Yachide Tomomi、Ohoka Nobumichi、Kurihara Masaaki、Naito Mikihiko、Tanaka Masakazu、Demizu Yosuke
    • Journal Title

      Bioorganic & Medicinal Chemistry

      Volume: 26 Issue: 8 Pages: 1638-1642

    • DOI

      10.1016/j.bmc.2018.02.010

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16J03592, KAKENHI-PROJECT-16K08340, KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-18K06570
  • [Journal Article] Phenanthridin-6-one derivatives as the first class of non-steroidal pharmacological chaperones for Niemann-Pick disease type C1 protein2017

    • Author(s)
      Hiromitsu Fukuda, Fumika Karaki, Kosuke Dodo, Tomomi Noguchi-Yachide, Minoru Ishikawa, Yuichi Hashimoto, Kenji Ohgane
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 27 Issue: 12 Pages: 2781-2787

    • DOI

      10.1016/j.bmcl.2017.04.062

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K15487, KAKENHI-PROJECT-25293027, KAKENHI-PROJECT-17H03996, KAKENHI-PROJECT-15K08015
  • [Journal Article] Synthesis and evaluation of novel dual BRD4/HDAC inhibitors2017

    • Author(s)
      Amemiya Seika、Yamaguchi Takao、Hashimoto Yuichi、Noguchi-Yachide Tomomi
    • Journal Title

      Bioorganig and Medicinal Chemistry

      Volume: 25 Issue: 14 Pages: 3677-3684

    • DOI

      10.1016/j.bmc.2017.04.043

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17H03996, KAKENHI-PROJECT-15K08015, KAKENHI-PROJECT-16K17930
  • [Journal Article] Switching subtype-selectivity: Fragment replacement strategy affords novel class of peroxisome proliferator-activated receptor α/δ (PPARα/δ) dual agonists2017

    • Author(s)
      Ryuta Shioi, Shogo Okazaki, Tomomi Noguchi-Yachide, Minoru Ishikawa, Makoto Makishima, Yuichi Hashimoto, Takao Yamaguchi
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters

      Volume: 27 Issue: 14 Pages: 3131-3134

    • DOI

      10.1016/j.bmcl.2017.05.037

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25293027, KAKENHI-PROJECT-17H03996, KAKENHI-PROJECT-15K08015, KAKENHI-PROJECT-16K17930
  • [Journal Article] Development of N6-(heteroarylcarbonyl)adenines as BRD4 inhibitors.2017

    • Author(s)
      Seika Amemiya、Takao Yamaguchi、Yuichi Hashimoto、 Tomomi Noguchi-Yachide
    • Journal Title

      Heterocycles

      Volume: 94 Issue: 6 Pages: 1107-1114

    • DOI

      10.3987/com-17-13667

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K08015, KAKENHI-PROJECT-16K17930
  • [Journal Article] BETブロモドメインを標的としたエピジェネティクス制御2017

    • Author(s)
      谷内出友美、橋本祐一
    • Journal Title

      MedChemNews

      Volume: 27 Pages: 213-218

    • Data Source
      KAKENHI-PROJECT-15K08015
  • [Journal Article] Structure-activity relationship study of N6-benzoyladenine-type BRD4 inhibitors and their effects on cell differentiation and TNF-α production.2016

    • Author(s)
      Seika Amemiya, Takao Yamaguchi, Taki Sakai, Yuichi Hashimoto, Tomomi Nogichi-Yachide
    • Journal Title

      Chemal and Pharmaceutical Bulletin

      Volume: 64 Pages: 1378-1383

    • NAID

      130005261607

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26293025
  • [Journal Article] Structure–Activity Relationship Study of <i>N</i><sup>6</sup>-Benzoyladenine-Type BRD4 Inhibitors and Their Effects on Cell Differentiation and TNF-α Production2016

    • Author(s)
      Seika Amemiya, Takao Yamaguchi, Taki Sakai, Yuichi Hashimoto, Tomomi Noguchi-Yachide
    • Journal Title

      Chemical and Pharmaceutical Bulletin

      Volume: 64 Issue: 9 Pages: 1378-1383

    • DOI

      10.1248/cpb.c16-00410

    • NAID

      130005261607

    • ISSN
      0009-2363, 1347-5223
    • Language
      English
    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15K08015
  • [Journal Article] BET Bromodomain as a Target of Epigenetic Therapy2016

    • Author(s)
      Tomomi Noguchi-Yachide
    • Journal Title

      Chemical and Pharmaceutical Bulletin

      Volume: 64 Issue: 6 Pages: 540-547

    • DOI

      10.1248/cpb.c16-00225

    • NAID

      130005154411

    • ISSN
      0009-2363, 1347-5223
    • Language
      English
    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15K08015
  • [Journal Article] Structure-activity relationship studies of non-carboxylic acid peroxisome proliferator-activated receptorα/δ (PPARα/δ) dual agonists2016

    • Author(s)
      Shogo Okazaki, Ryuta Shioi, Tomomi Noguchi-Yachide, Minoru Ishikawa, Makoto Makishima, Yuichi Hashimoto, Takao Yamaguchi
    • Journal Title

      Bioorganic & Medicinal Chemistry

      Volume: 24 Issue: 21 Pages: 5455-5461

    • DOI

      10.1016/j.bmc.2016.08.067

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25293027, KAKENHI-PROJECT-15K08015, KAKENHI-PROJECT-16K17930
  • [Journal Article] Discovery of N-(1-(3-(4-phenoxyphenyl)-1,2,4-oxadiazol-5-yl)ethyl)acetamides as novel acetyl-CoA carboxylase 2 (ACC2) inhibitors with peroxisome proliferator-activated receptor α/δ (PPARα/δ) dual agonistic activit2016

    • Author(s)
      Shogo Okazaki, Tomomi Noguchi-Yachide, Taki Sakai, Minoru Ishikawa, Makoto Makishima, Yuichi Hashimoto, Takao Yamaguchi
    • Journal Title

      Bioorganic & Medicinal Chemistry

      Volume: 24 Issue: 21 Pages: 5258-5269

    • DOI

      10.1016/j.bmc.2016.08.045

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25293027, KAKENHI-PROJECT-26293025, KAKENHI-PROJECT-15K08015, KAKENHI-PROJECT-16K15137, KAKENHI-PROJECT-16K17930
  • [Journal Article] Efficient protein knockdown of HaloTag-fused proteins using hybrid molecules consisting of IAP antagonist and HaloTag ligand2016

    • Author(s)
      Shusuke Tomoshige, Yuichi Hashimoto, Minoru Ishikawa
    • Journal Title

      Bioorganic & Medicinal Chemistry

      Volume: 24 Issue: 14 Pages: 3144-3148

    • DOI

      10.1016/j.bmc.2016.05.035

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25293027, KAKENHI-PROJECT-26293025, KAKENHI-PROJECT-16K15137
  • [Journal Article] Synthesis of new hydantoins bearing glutarimide or succinimide moiety and their evaluation for cell differentiation-inducing and anti-angiogenic activities.2015

    • Author(s)
      Jun-ichi Yamaguchi, Tomomi Noguchi-Yachide, Yuka Sakaguchi, Chiaki Shibata, Shinnosuke Kanuma, Akiko Yoshizaki, Yuka Takizawa, Yuichi Hashimoto.
    • Journal Title

      Heterocycles

      Volume: 91 (4) Issue: 4 Pages: 764-781

    • DOI

      10.3987/com-15-13184

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K08015
  • [Journal Article] Discovery and structure-;activity relationship studies of N6-benzoyladenine derivatives as novel BRD4 inhibitors2015

    • Author(s)
      Noguchi-Yachide, T., Sakai, T., Hashimoto, Y., Yamaguchi, Y.
    • Journal Title

      Bioorganic & Medicinal Chemistry

      Volume: 23 Issue: 5 Pages: 953-959

    • DOI

      10.1016/j.bmc.2015.01.022

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26293025, KAKENHI-PROJECT-26810091, KAKENHI-PROJECT-15K08015
  • [Journal Article] Effects of alkyl side chains and terminal hydrophilicity on vitamin D receptor (VDR) agonistic activity based on the diphenylpentane skeleton2015

    • Author(s)
      Takashi Misawa, Momoko Yorioka, Yosuke Demizu, Tomomi Noguchi-Yachide, Nobumichi Ohoka, Megumi Kurashima-Kinoshita, Hitomi Motoyoshi, Hisao Nojiri, Atsushi Kittaka, Makoto Makishima, Mikihiko Naito, Masaaki Kurihara
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 25 Issue: 22 Pages: 5362-5366

    • DOI

      10.1016/j.bmcl.2015.09.030

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K07869, KAKENHI-PROJECT-15K08015, KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-15K18905, KAKENHI-PROJECT-26860049
  • [Journal Article] Structure–activity relationships of oxysterol-derived pharmacological chaperones for Niemann–Pick type C1 protein.2014

    • Author(s)
      Ohgane, K., Karaki, F., Noguchi-Yachide, T., Dodo, K. Hashimoto, Y.
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters

      Volume: 24 Issue: 15 Pages: 3480-3485

    • DOI

      10.1016/j.bmcl.2014.05.064

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-13J06522, KAKENHI-PROJECT-25670052, KAKENHI-PROJECT-26293025
  • [Journal Article] Small-molecular, non-peptide, non-ATP-competitive polo-like kinase 1 (Plk1) inhibitors with a terphenyl skeleton2013

    • Author(s)
      Yusuke Mita, Tomomi Noguchi- Yachide, Minoru Ishikawa and Yuichi Hashimoto
    • Journal Title

      Bioorg. Med. Chem

      Volume: 21 Pages: 608-617

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790107
  • [Journal Article] Sructure-activity relationship of benzodiazepine derivatives as LXXLL peptide mimetics that inhibit the interaction of vitamin D receptor with2013

    • Author(s)
      Noguchi- Yachide, Yuichi Hashimoto and Minoru Ishikawa
    • Journal Title

      Bioorg. Med. Chem

      Volume: 21 Pages: 993-1005

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790107
  • [Journal Article] Small-molecular inhibitors of Ca2+-induced mitochondrial permeability transition (MPT) derived from muscle relaxant dantrolene.2012

    • Author(s)
      Shunpei Murasawa, Katsuya Iuchi, Shinichi Sato, Tomomi Noguchi- Yachide, Mikiko Sodeoka, Tsutomu Yokomatsu, Kosuke Dodo, Yuichi Hashimoto, Y. and Hiroshi Aoyama
    • Journal Title

      Bioorg. Med. Chem.

      Volume: 20 Pages: 6384-6393

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790107
  • [Journal Article] Design, synthesis, and biological evaluation of novel transrepression-selective liver X receptor (LXR) ligands with 5,11-dihydro-5-methyl-11-methylene-6 Hdibenz[b,e]azepin-6-one skeleton.2012

    • Author(s)
      Atsushi Aoyama, Kaori Endo-Umeda, Kenji Kishida, Kenji Ohgane, Tomomi Noguchi- Yachide, Hiroshi Aoyama, Minoru Ishikawa, Hiroyuki Miyachi, Makoto Makishima and Yuichi Hashimoto
    • Journal Title

      J. Med. Chem

      Volume: 55 Pages: 7360-7377

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790107
  • [Journal Article] Design, synthesis, and biological evaluation of novel transrepression-selective liver X receptor (LXR) ligands with 5,11-dihydro-5-methyl-11-methylene-6H-dibenz[b,e]-azepin-6-one skeleton.2012

    • Author(s)
      Atsushi Aoyama
    • Journal Title

      Journal of Medicinal Chemistry

      Volume: 55 Issue: 17 Pages: 7360-7377

    • DOI

      10.1021/jm3002394

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790107, KAKENHI-PROJECT-22249006
  • [Journal Article] Specific Inhibitors of Puromycin-Sensitive Aminopeptidase with a 3-(Halogenated Phenyl)-2,4(1H,3H)-quinazolinedione Skeleton.2012

    • Author(s)
      Yotaro Matsumoto, Tomomi Noguchi- Yachide, Masaharu Nakamura, Yusuke Mita, Akiyoshi Numadate, and Yuichi Hashimoto.
    • Journal Title

      Heterocycles

      Volume: 86 Pages: 1449-1463

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790107
  • [Journal Article] Further Application of the Multi-Templ ate Approach f or Creati on of Biological Response Modifiers: Discovery of a New Class of Multifunctional Anti-Diabetic Agents.2011

    • Author(s)
      Kazunori Motoshima, Tomomi Noguchi- Yachi de, Minoru Ishikawa, Yui chi Hashi moto, and Kazuyuki Sugita
    • Journal Title

      Heterocycles

      Volume: 82 (2) Pages: 1083-1101

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790107
  • [Journal Article] Further application of the multitemplate approach for creation of biological response modifiers : discovery of a new class of multifunctional anti-diabetic agents2011

    • Author(s)
      K.Motoshima, T.Noguchi-Yachide, M.Ishikawa, Y.Hashimoto, K.Sugita
    • Journal Title

      Heterocycles

      Volume: 82 Issue: 2 Pages: 1083-1101

    • DOI

      10.3987/rev-10-sr(e)7

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22249006
  • [Journal Article] Further Application of the Multi-Template Approach for Creation of Biological Response Modifiers : Discovery of a New Class of Multifunctional Anti-Diabetic Agents2011

    • Author(s)
      Kazunori Motoshima, Tomomi Noguchi-Yachide, 他3名
    • Journal Title

      Heterocycles

      Volume: 82 Pages: 1083-1101

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790107
  • [Journal Article] Estrogen receptor α/β ligands derived from thalidomide2011

    • Author(s)
      Tomomi Noguchi-Yachide, 他2名
    • Journal Title

      Heterocycles

      Volume: 83 Pages: 2137-2147

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790107
  • [Journal Article] Estrogen receptor α/β ligands derived from thalidomide.2011

    • Author(s)
      Tomomi Noguchi - Yachi de, Kazuyuki Sugita and Yuichi Hashimoto.
    • Journal Title

      Heterocycles

      Volume: 83 (9) Pages: 2137-2147

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790107
  • [Journal Article] Estrogen receptor α/β ligands derived from thalidomide2011

    • Author(s)
      T.Noguchi-Yachide, K.Sugita, Y.Hashimoto
    • Journal Title

      Heterocycles

      Volume: 83 Issue: 9 Pages: 2137-2147

    • DOI

      10.3987/com-11-12287

    • NAID

      40018958922

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22249006
  • [Journal Article] Novel Selective Anti-androgens with a Diphenylpentane Skeleton2010

    • Author(s)
      Keisuke Maruyama, Tomomi Noguchi- Yachi de, Kazuyuki Sugita, Yui chi Hashi moto and Mi noru Ishikawa
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 20 Pages: 6661-6666

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790107
  • [Journal Article] Identification of Binding Proteins of Fusarielin A as Actin and Tubulin2010

    • Author(s)
      T.Noguchi-Yachide, 他6名
    • Journal Title

      Chemical & Pharmaceutical Bulletin 58・1

      Pages: 129-134

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790107
  • [Journal Article] Identification of binding proteins of fusarielin A as actin and tubulin2010

    • Author(s)
      Tomomi Noguchi-Yachide, 他6名
    • Journal Title

      Chemical & Pharmaceutical Bulletin 58

      Pages: 129-134

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016013
  • [Journal Article] Identification of binding proteins of fusarielin A as actin and tubulin.2010

    • Author(s)
      Tomomi Noguchi-Yachide, 他6名
    • Journal Title

      Chemical & Pharmaceutical Bulletin 58

      Pages: 129-134

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390028
  • [Journal Article] LXXLL peptide mimetics as inhibitors of the interaction of vitamin Dreceptor with coactivators2010

    • Author(s)
      Y.Mita, K.Dodo, T.Noguchi-Yachide, 他4名
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters 20

      Pages: 1712-1717

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790107
  • [Journal Article] LXXLL peptide mimetics as inhibitorsof the interaction of vitamin D receptorwith coactivators2010

    • Author(s)
      Noguchi- Yachi de, Hiroyuki Miyachi, Makoto Makishima, Yuichi Hashimoto and Minoru Ishikawa
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 20 Pages: 1712-1717

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790107
  • [Journal Article] LXXLL peptide mimetics as inhibitors of the interaction of vitamin D receptor with coactivators.2010

    • Author(s)
      Mita Y, Dodo K, Noguchi-Yachide T, Miyachi H, Makishima M, Hashimoto Y, Ishikawa M
    • Journal Title

      Bioorg. Med. Chem. Lett. 20(5)

      Pages: 1712-1717

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390028
  • [Journal Article] b-Naphthoflavone analogs as potentand soluble aryl hydrocarbon receptoragonists: Improvement of solubility bydisruption of molecular planarity2010

    • Author(s)
      Yuj i Fuj i ta, Mi tsuhi ro Yonehara, Masashi Tetsuhashi, Tomomi Noguchi- Yachi de, Yuichi Hashimotoand Minoru Ishikawa
    • Journal Title

      Bioorg. Med. Chem.

      Volume: 18 Pages: 1194-1203

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790107
  • [Journal Article] Novel selective anti-androgens with a diphenylpentane skeleton2010

    • Author(s)
      K.Maruyama, T.Noguchi-Yachide, K.Sugita, Y.Hashimoto, M.Ishikawa
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 20 Issue: 22 Pages: 6661-6666

    • DOI

      10.1016/j.bmcl.2010.09.011

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22249006
  • [Journal Article] β-Naphthoflavone analogs as potent and soluble aryl hydrocarbon receptor agonists : Improvement of solubility by disruption of molecular planarity2010

    • Author(s)
      Y.Fujita, M.Yonehara, M.Tetsuhashi, T.Noguchi-Yachide, 他2名
    • Journal Title

      Bioorganic & Medicinal Chemistry 18

      Pages: 1194-1203

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790107
  • [Journal Article] Separation of α-glucosidase-inhibitory and liver X receptor-antagonistic activities of phenethylphenyl phthalimide analogs and generation of LXRα-selective antagonists2009

    • Author(s)
      K.Motoshima, T.Noguchi-Yachide, 他3名
    • Journal Title

      Bioorganic & Medicinal Chemistry 17

      Pages: 5001-5014

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790107
  • [Journal Article] Enhancement of chemically-induced HL-6o cell differentiation by 3,3'-diindolylmethane derivatives2009

    • Author(s)
      Tomomi Noguchi-Yachide, 他3名
    • Journal Title

      Chemical & Pharmaceutical Bulletin 57

      Pages: 536-540

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016013
  • [Journal Article] Enhancement of Chemically-induced HL-60 Cell Differentiation by 3,3'-Diindolylmethane (DIM) Derivatives.2009

    • Author(s)
      Tomomi Noguchi - Yachi de, Masashi Tetsuhashi , Hi roshi Aoyama and Yui chi Hashimoto.
    • Journal Title

      Chem. Pharm. Bull.

      Volume: 57(5) Pages: 536-540

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790107
  • [Journal Article] Enhancement of Chemically-induced HL-60 Cell Differentiation by 3, 3'-Diindolylmethane (DIM) Derivatives2009

    • Author(s)
      T. Noguchi-Yachide, 他3名
    • Journal Title

      Chemical & Pharmaceutical Bulletin 57・5(掲載確定)(Online publish ed (Accepted))

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18790084
  • [Journal Article] Separation of α-glucosidase-inhibitoryand liver X receptor-antagonistic activities of phenethylphenyl phthalimide analogs and generation of LXR-selective antagonists.2009

    • Author(s)
      Kazunori Motoshima, Tomomi Noguchi- Yachide, Kazuyuki Sugita,Yuichi Hashimoto and Minoru Ishikawa.
    • Journal Title

      Bioorg. Med. Chem.

      Volume: 17 Pages: 5001-5014

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790107
  • [Journal Article] Enhancement of chemically-induced HL-60 cell differentiation by 3, 3'-diindolulmethane derivatives.2009

    • Author(s)
      Noguchi-Yachide T, Tetsuhashi M, Aoyama H, Hashimoto Y
    • Journal Title

      Chem. Pharm. Bull. 57(5)

      Pages: 536-540

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016013
  • [Journal Article] Enhancement of chemically-induced HL-6o cell differentiation by 3,3'-diindolylmethane derivatives.2009

    • Author(s)
      Tomomi Noguchi-Yachide, 他3名
    • Journal Title

      Chemical & Pharmaceutical Bulletin 57

      Pages: 536-540

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390028
  • [Journal Article] Co-existence of a-glucosidase-inhibitory and liver X receptor-regulatory activities and their separation by structural development2008

    • Author(s)
      K. Dodo, A. Aoyama, T. Noguchi-Yachide, 他3名
    • Journal Title

      Bioorganic & Medicinal Chemistry 16・8

      Pages: 4272-4285

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18790084
  • [Journal Article] Fusarielin A as an Anti-angiogenic and Anti-proliferative Agent: Its Basic Biological Characterization2008

    • Author(s)
      Haruka Fujimoto, hiroshi Aoyama, Tomomi Noguchi-Yachide, 他2 名
    • Journal Title

      Chem. Pharm. Bull. 56(3)

      Pages: 298-304

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18790084
  • [Journal Article] Co-existence of a-glucosidase-inhibitory and liver X receptor-regulatory activities and their separation by structural development2008

    • Author(s)
      Kousuke Dodo, Atsushi Aoyama, Tomomi Noguchi-Yachide, 他3 名
    • Journal Title

      Bioorg. Med. Chem. 16(8)

      Pages: 4272-4285

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18790084
  • [Journal Article] Anriproliferative and apoptosis-inducing activities of alkyl gallate and gallamide derivatives related to (-)-epigallocatechin gallate.2008

    • Author(s)
      Dodo K, Minato T, Noguchi-Yachide T, Suganuma M, Hashimoto Y
    • Journal Title

      Bioorg. Med. Chem. 16(17)

      Pages: 7975-7982

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016013
  • [Journal Article] Antiproliferative and apoptosis-inducing activities of alkyl gallate and gallamide derivatives related to (-)-epigallocatechin gallete2008

    • Author(s)
      Kousuke Dodo, Taro Minato, Tomomi Noguchi-Yachide, 他2 名
    • Journal Title

      Bioorg. Med. Chem. 16(17)

      Pages: 7975-7982

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18790084
  • [Journal Article] Fusarielin A as an Anti-angiogenic and Anti-proliferative Agent : Its Basic Biological Characterization2008

    • Author(s)
      H.Fujimoto, H.Aoyama, T.Noguchi-Yachide, 他2名
    • Journal Title

      Chemical & Pharmaceutical Bulletin 56・3

      Pages: 298-304

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18790084
  • [Journal Article] Novel tubuln-polymerization inhibitor derived from thalidomide directly induces apoptosis in human multiple myeloma cells : possible anti-mveloma mechanism of thalidomide2008

    • Author(s)
      T.Iguchi, T.Noguchi-Yachide, 他5名
    • Journal Title

      International Journal of Molecular Medicine 56・3

      Pages: 298-304

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18790084
  • [Journal Article] Antiproliferative and apoptosis-inducing activities of alkyl gallate and gallamide derivatives related to(-)-epigallocatechin gallete2008

    • Author(s)
      K. Dodo, T. Minato, T-Nogllchi-Yachide, 他2名
    • Journal Title

      flioorganic & Medicinal Chemistry 16・17

      Pages: 7975-7982

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18790084
  • [Journal Article] Co-existence of alpha-glucosidase-inhibitory activity and liver X receptor-regulatory activities and their separation by structural development.2008

    • Author(s)
      Dodo K, Aoyama H, Noguchi-Yachide T, Makishima M, Miyachi H, Hashimoto Y
    • Journal Title

      Bioorg. Med. Chem. 16(8)

      Pages: 4272-4285

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390028
  • [Journal Article] Novel tubuln-polymerization inhibitor derived from thalidomide directly induces apoptosis in human multiple myeloma cells: possible anti-myeloma mechanism of thalidomide2008

    • Author(s)
      Toyotaka Iguchi, Tomomi Noguchi-Yachide, 他5 名
    • Journal Title

      Int. J. Mol. Med. 21

      Pages: 163-168

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18790084
  • [Journal Article] Liver X receptor antagonists with a phthalimide skeleton derived from thahlidomide-related glucosidase inhibitors2007

    • Author(s)
      T. Noguchi-Yachide, 他4名
    • Journal Title

      Bioorganic & Medicnal Chemistry Letters 17

      Pages: 3957-3961

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390028
  • [Journal Article] Hydrolyzed Metabolites of Thalidomide: Synthesis and TNF-a Production-inhibitory Activity2007

    • Author(s)
      Takanori Nakamura, Tomomi Noguchi, 他3名
    • Journal Title

      Chem. Pharm. Bull. 55(4)

      Pages: 651-654

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18790084
  • [Journal Article] Structural Development of Liver X Receptor (LXR) Antagonists Derived from Thalidomide-related Glucosidase Inhibitors2007

    • Author(s)
      Tomomi Noguchi-Yachide, 他5 名
    • Journal Title

      Chem. Pharm. Bull. 55(12)

      Pages: 1750-1754

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18790084
  • [Journal Article] Development of tubulin-Polymerization Inhibitors Based on the Thalidomide Skeleton2007

    • Author(s)
      Hiroshi Aoyama, Tomomi Noguchi, 他5名
    • Journal Title

      Chem. Pharm. Bull. 55(6)

      Pages: 944-949

    • NAID

      110006278705

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18790084
  • [Journal Article] Liver X Receptor Antagonists with a Phthalimide Skeleton Derived from Thalidomide-related Glucosidase Inhibitors2007

    • Author(s)
      Tomomi Noguchi-Yachide, 他4 名
    • Journal Title

      Bioorg. Med. Chem. Lett. 17(14)

      Pages: 3957-3961

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18790084
  • [Journal Article] Structural development of liver X receptor(LXR)antagonists with a phthalimide skeleton derived from thalidomide-related glucosidase inhibitors2007

    • Author(s)
      T. Noguchi-Yachide, 他5名
    • Journal Title

      Chemical & Pharmaceutical Bulletin 55

      Pages: 1750-1754

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390028
  • [Journal Article] Development of tubulin-polymerization inhibitors based on thalidomide skeleton.2007

    • Author(s)
      Aoyama H, Noguchi T, Misawa T, Nakamura T, Miyachi H, Hashimoto Y, Kobayashi H
    • Journal Title

      Chem. Pharm. Bull. 55(6)

      Pages: 844-949

    • NAID

      110006278705

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016013
  • [Journal Article] Liver X Receptor Antagonists with a Phthalimide Skeleton Derived from Thalidomide-related Glucosidase Inhibitors.2007

    • Author(s)
      Tomomi Noguchi-Yachide, 他4名
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters 17・14

      Pages: 3957-3961

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18790084
  • [Journal Article] Effects of immunomodulatory derivatives of thalidomide (IMiDs) and their analogs on cell-differentiation, cyclooxygenase activity and angiogenesis.2006

    • Author(s)
      Fujimoto H, Noguchi T, Kobayashi H, Miyachi H, Hashimoto Y
    • Journal Title

      Chem. Pharm. Bull. 54(6)

      Pages: 855-860

    • NAID

      110004836392

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016013
  • [Journal Article] Tubulin polymerization inhibitors with a fluorinated phthalimide skeleton derived from thalidomide2006

    • Author(s)
      Tomonori Yanagawa, Tomomi Noguchi, 他3名
    • Journal Title

      Bioorg. Med. Chem. Lett. 16(18)

      Pages: 4748-4751

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18790084
  • [Journal Article] Mono- and Dihydroxylated Metabolites of Thalidomide: Synthesis and TNF-a Production-inhibitory Activity2006

    • Author(s)
      Takanori Nakamura, Tomomi Noguchi, 他3名
    • Journal Title

      Chem. Pharm. Bull. 54(12)

      Pages: 1709-1714

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18790084
  • [Journal Article] Anti-angiogenic activity of basic-type, selective cyclooxygenase (COX)-1 inhibitors2006

    • Author(s)
      Hiroko Sano, Tomomi Noguchi, 他3 名
    • Journal Title

      Bioorg. Med. Chem. Lett. 16(11)

      Pages: 3068-3072

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18790084
  • [Journal Article] Design and synthesis of subtype-selective cyclooxygenase (COX) inhibitors derived from thalidomide.2005

    • Author(s)
      H.Sano, T.Noguchi, A.Tanatani, 他2名
    • Journal Title

      Bioorganic & Medicinal Chemistry 13・9

      Pages: 3079-3091

    • Data Source
      KAKENHI-PROJECT-17016013
  • [Journal Article] Angiogenesis inhibitors derived from thalidomide.2005

    • Author(s)
      T.Noguchi, H.Fujimoto, H.Sano, 他3名
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters 15・24

      Pages: 5509-5513

    • Data Source
      KAKENHI-PROJECT-17016013
  • [Journal Article] Cell differentiation inducers derived from thalidomide2005

    • Author(s)
      T.Noguchi, h.Miyachi, R.Katayama, 他2名
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters 15・13

      Pages: 3121-3215

    • Data Source
      KAKENHI-PROJECT-17016013
  • [Presentation] 薬の研究って何だろう?2019

    • Author(s)
      谷内出友美
    • Organizer
      かながわリケジョ・エンカレッジプログラム(かながわ女性の活躍応援団啓発講座)
    • Invited
    • Data Source
      KAKENHI-PROJECT-18K06570
  • [Presentation] Development of bioactive compounds based on bis-aryl (6-X-Y-6) skeleton.2019

    • Author(s)
      T. Noguchi-Yachide, K. Ohgane, Y. Hashimoto
    • Organizer
      BIOHETEROCYCLES 2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K06570
  • [Presentation] ER downregulationの母核横断的な構造活性相関2018

    • Author(s)
      南條舜、谷内出友美、吉岡広大、槇島誠、石川稔、橋本祐一、大金賢司
    • Organizer
      日本薬学会第138年会
    • Data Source
      KAKENHI-PROJECT-15K08015
  • [Presentation] Development of dual BRD4/HDAC inhibitors2018

    • Author(s)
      Tomomi Noguchi-Yachide, Seika Amemiya, Takao Yamaguchi, Yuichi Hashimoto
    • Organizer
      RICT2018
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K06570
  • [Presentation] ItraconazoleのNPC1シャペロンとしての構造活性相関研究2018

    • Author(s)
      安藤有輝、塩井隆太、吉岡広大、谷内出友美、石川稔、橋本祐一、大金賢司
    • Organizer
      日本薬学会第138年会
    • Data Source
      KAKENHI-PROJECT-15K08015
  • [Presentation] ERダウンレギュレーターの構造活性相関研究2018

    • Author(s)
      谷内出友美、南條舜、大金賢司、橋本祐一
    • Organizer
      レチノイド研究会学術集会
    • Data Source
      KAKENHI-PROJECT-18K06570
  • [Presentation] 二原子スペーサー連結bis-aryl骨格(6-X-Y-6)を基盤とした生理活性物質創製研究2017

    • Author(s)
      谷内出(野口)友美
    • Organizer
      第35回メディシナルケミストリーシンポジウム
    • Invited
    • Data Source
      KAKENHI-PROJECT-15K08015
  • [Presentation] ドラッグリポジショニングによるニーマンピック病C型に対するシャペロンドラッグの探索2017

    • Author(s)
      大金賢司、 塩井隆太、 安藤有輝、 谷内出友美、 石川稔、 どど孝介、 袖岡幹子、 橋本祐一
    • Organizer
      第35回メディシナルケミストリーシンポジウム
    • Data Source
      KAKENHI-PROJECT-15K08015
  • [Presentation] BET ブロモドメインを標的としたエピジェネティクス制御2017

    • Author(s)
      谷内出(野口)友美、雨宮聖花、山口卓男、橋本祐一
    • Organizer
      第61回日本薬学会関東支部大会
    • Data Source
      KAKENHI-PROJECT-15K08015
  • [Presentation] PPARα/δデュアル転写誘導活性を有する新規ACC2 阻害剤の創出2016

    • Author(s)
      山口卓男、岡崎翔吾、境太希、谷内出友美、石川稔、橋本祐一
    • Organizer
      日本ケミカルバイオロジー学会第11回年会
    • Place of Presentation
      京都テルサ(京都府京都市)
    • Year and Date
      2016-06-15
    • Data Source
      KAKENHI-PROJECT-15K08015
  • [Presentation] 核内受容体リガンドを指向した1,3,5-トリアジン誘導体の設計と構造展開2016

    • Author(s)
      海東 和麻, 谷内出 友美, 中津 亜紀, 森 修一, 橋本 祐一, 影近 弘之, 藤井 晋也
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2016-03-26
    • Data Source
      KAKENHI-PROJECT-15K08015
  • [Presentation] アンドロゲン受容体AF-1モジュレーターの構造展開2016

    • Author(s)
      沼館慧剛、谷内出友美、梅田香織、槇島誠、橋本祐一、藤井晋也
    • Organizer
      日本ケミカルバイオロジー学会第11回年会
    • Place of Presentation
      京都テルサ(京都府京都市)
    • Year and Date
      2016-06-15
    • Data Source
      KAKENHI-PROJECT-15K08015
  • [Presentation] 新規BRD4/HDAC二重阻害活性化合物の創製.2016

    • Author(s)
      雨宮聖花、山口卓男、境太希、橋本祐一、谷内出友美
    • Organizer
      第34回メディシナルケミストリーシンポジウム
    • Place of Presentation
      つくば国際会議場(茨城県つくば市)
    • Year and Date
      2016-11-30
    • Data Source
      KAKENHI-PROJECT-26293025
  • [Presentation] AF-1領域による機能制御を指向した新規アンドロゲン受容体モジュレーターの創製2016

    • Author(s)
      沼館慧剛、谷内出友美、梅田香織、槇島誠、橋本祐一、藤井晋也
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-03-26
    • Data Source
      KAKENHI-PROJECT-26293025
  • [Presentation] N6-ベンゾイルアデニン骨格を有する新規BRD4阻害剤の創製研究.2016

    • Author(s)
      谷内出友美、橋本祐一
    • Organizer
      第20回日本がん分子標的治療学会学術集会
    • Place of Presentation
      大分県別府市別府国際コンベンションセンター(大分県別府市)
    • Year and Date
      2016-05-30
    • Data Source
      KAKENHI-PROJECT-26293025
  • [Presentation] 核内受容体リガンドを指向した1,3,5-トリアジン誘導体の設計と構造展開2016

    • Author(s)
      海東和麻、谷内出友美、中津亜紀、森修一、橋本祐一、影近弘之、藤井晋也
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-03-26
    • Data Source
      KAKENHI-PROJECT-26293025
  • [Presentation] N6-ベンゾイルアデニン骨格を有する新規BRD4阻害剤の創製研究2016

    • Author(s)
      谷内出友美、橋本祐一
    • Organizer
      第20回日本がん分子標的治療学会学術集会
    • Place of Presentation
      別府国際コンベンションセンター(大分県別府市)
    • Year and Date
      2016-05-30
    • Data Source
      KAKENHI-PROJECT-15K08015
  • [Presentation] PPARα/δデュアル転写誘導活性を有する新規ACC2阻害剤の創出.2016

    • Author(s)
      山口卓男、岡崎翔吾、境太希、谷内出友美、石川稔、橋本祐一
    • Organizer
      日本ケミカルバイオロジー学会第11回年会
    • Place of Presentation
      京都テルサ(京都府京都市)
    • Year and Date
      2016-06-15
    • Data Source
      KAKENHI-PROJECT-26293025
  • [Presentation] ビタミンD受容体 (VDR) の活性を制御するノンセコステロイド型VDRリガンドの創製2016

    • Author(s)
      三澤隆史、出水庸介、谷内出友美、大岡伸通、木下恵愛、野尻久雄、橘高敦史、槇島誠、内藤幹彦、栗原正明
    • Organizer
      日本ビタミン学会第68大会
    • Place of Presentation
      富山国際会議場(富山県富山市)
    • Year and Date
      2016-06-17
    • Data Source
      KAKENHI-PROJECT-15K08015
  • [Presentation] &#61548;ベンゾイルアデニン骨格を有する新規BRD4 阻害剤の創製2016

    • Author(s)
      雨宮 聖花, 境 太希, 橋本 祐一, 山口 卓男, 谷内出 友美
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2016-03-26
    • Data Source
      KAKENHI-PROJECT-15K08015
  • [Presentation] AF-1 領域による機能制御を指向した新規アンドロゲン受容体モジュレーターの創製2016

    • Author(s)
      沼館 慧剛, 谷内出 友美, 梅田 香織, 槇島 誠, 橋本 祐一, 藤井 晋也
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2016-03-26
    • Data Source
      KAKENHI-PROJECT-15K08015
  • [Presentation] ベンゾイルアデニン骨格を有する新規BRD4阻害剤の創製2016

    • Author(s)
      雨宮聖花、境太希、橋本祐一、山口卓男、谷内出友美
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-03-26
    • Data Source
      KAKENHI-PROJECT-26293025
  • [Presentation] Development of pharmacological chaperone candidates for Retinitis Pigmentosa and Niemann-Pick type C1 disease.2015

    • Author(s)
      Tomomi Noguchi-Yachide
    • Organizer
      IWBBIO2015 (3rd International Work-Conference on Bioinformatics and Biomedical Engineering)
    • Place of Presentation
      Science Faculty of the University of Granada, Granada, Spain
    • Year and Date
      2015-04-15
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26293025
  • [Presentation] アンドロゲン受容体AF-1モジュレーターの創製2015

    • Author(s)
      沼館慧剛、谷内出友美、梅田香織、槇島誠、橋本祐一、藤井晋也
    • Organizer
      日本ケミカルバイオロジー学会 第10回年会
    • Place of Presentation
      東北大学(宮城県・仙台市)
    • Year and Date
      2015-06-10
    • Data Source
      KAKENHI-PROJECT-15K08015
  • [Presentation] 新規PPARαアゴニストの探索と構造展開、およびhACC2阻害活性評価2015

    • Author(s)
      岡崎 翔吾、境 太希、谷内出 友美、石川 稔、橋本 祐一、山口 卓男
    • Organizer
      第33回メディシナルケミストリーシンポジウム
    • Place of Presentation
      幕張国際研修センター(千葉県・千葉市)
    • Year and Date
      2015-11-25
    • Data Source
      KAKENHI-PROJECT-15K08015
  • [Presentation] Novel BRD4 inhibitors with a N6-benzoyladenine skeleton2015

    • Author(s)
      T. Noguchi-Yachide, T. Sakai, Y. Hashimoto, T. Yamaguchi
    • Organizer
      PACIFICHEM 2015 (2015 International Chemical Congress of Pacific Basin Societies)
    • Place of Presentation
      Honolulu, Hawaii (USA)
    • Year and Date
      2015-12-15
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26293025
  • [Presentation] Development of pharmacological chaperone candidates for Retinitis Pigmentosa and Niemann-Pick type C1 disease.2015

    • Author(s)
      Tomomi Noguchi-Yachide
    • Organizer
      IWBBIO 2015 (3rd International Work-Conference on Bioinformatics and Biomedical Engineering)
    • Place of Presentation
      The University of Granada (Granada, Spain)
    • Year and Date
      2015-04-15
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08015
  • [Presentation] ノンセコステロイド型ビタミンD受容体リガンドの創製~官能基変換による活性制御~2015

    • Author(s)
      三澤隆史、依岡桃子、出水庸介、谷内出友美、大岡伸通、木下恵愛、野尻久雄、橘高敦史、槇島誠、内藤幹彦、栗原正明
    • Organizer
      第33回メディシナルケミストリーシンポジウム
    • Place of Presentation
      幕張国際研修センター(千葉県・千葉市)
    • Year and Date
      2015-11-25
    • Data Source
      KAKENHI-PROJECT-15K08015
  • [Presentation] 新規PPARαアゴニストの探索と構造展開、およびhACC2阻害活性評価2015

    • Author(s)
      岡崎翔吾、境太希、谷内出友美、石川稔、橋本祐一、山口卓男
    • Organizer
      第33回メディシナルケミストリーシンポジウム
    • Place of Presentation
      幕張国際研究センター(千葉県千葉市)
    • Year and Date
      2015-11-25
    • Data Source
      KAKENHI-PROJECT-26293025
  • [Presentation] Novel BRD4 inhibitors with a N6-benzoyladenine skeleton2015

    • Author(s)
      Tomomi Noguchi-Yachide, Taki Sakai, Yuichi Hashimoto, Takao Yamaguchi
    • Organizer
      The international chemical congress of pacific basin societies (Pacifichem2015)
    • Place of Presentation
      Hawaii Convention Center (Hawaii, USA)
    • Year and Date
      2015-12-15
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08015
  • [Presentation] Development of androgen receptor (AR) activation function-1 (AF-1) modulators2015

    • Author(s)
      Shinya Fujii, Akiyoshi Numadate, Tomomi Noguchi-Yachide, Kaori Endo-Umeda, Makoto Makishima, and Yuichi Hashimoto
    • Organizer
      The 3rd International Conference on Retinoids
    • Place of Presentation
      岐阜グランドホテル(岐阜県岐阜市)
    • Year and Date
      2015-10-21
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26293025
  • [Presentation] 免疫調節作用選択的な肝臓X受容体(LXR)リガンドの創製2012

    • Author(s)
      青山惇、梅田(遠藤)香織、岸田健治、大金賢司、谷内出(野口)友美、青山洋史、石川稔、宮地弘幸、槇島誠、橋本祐一
    • Organizer
      日本レチノイド研究会第23回学術集会
    • Place of Presentation
      鳥取県米子市
    • Year and Date
      2012-10-19
    • Data Source
      KAKENHI-PROJECT-21790107
  • [Presentation] サリドマイド由来エストロゲン受容体リガンドの創製2012

    • Author(s)
      谷内出友美, 他3名
    • Organizer
      日本薬学会132年会
    • Place of Presentation
      北海道大学
    • Data Source
      KAKENHI-PROJECT-21790107
  • [Presentation] サリドマイド由来エストロゲン受容体リガンドの創製2012

    • Author(s)
      谷内出友美、松本洋太郎、杉田和幸、橋本祐一
    • Organizer
      日本薬学会132年会
    • Place of Presentation
      北海道札幌市
    • Data Source
      KAKENHI-PROJECT-21790107
  • [Presentation] サリドマイド由来エストロゲン受容体リガンドの創製2012

    • Author(s)
      谷内出友美、杉田和幸、松本洋太郎、橋本祐一
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-22249006
  • [Presentation] LXXLL配列を模倣したVDR-コアクチベーター相互作用阻害物質の構造活性相関2012

    • Author(s)
      三田裕介、どど孝介、谷内出友美、橋本祐一、石川稔
    • Organizer
      日本薬学会132年会
    • Place of Presentation
      北海道札幌市
    • Data Source
      KAKENHI-PROJECT-21790107
  • [Presentation] 疫調節作用選択的な肝臓X受容体(LXR)リガンドの創製2012

    • Author(s)
      青山惇、梅田(遠藤)香織、岸田健治、大金賢司、谷内出(野口)友美、青山洋史、石川稔、宮地弘幸、槇島誠、橋本祐一
    • Organizer
      日本レチノイド研究会第23回学術集会
    • Place of Presentation
      米子
    • Data Source
      KAKENHI-PROJECT-22249006
  • [Presentation] 虚血性細胞死抑制活性を有する低分子化合物の創製2012

    • Author(s)
      村澤慎平、青山洋史、どど孝介、谷内出友美、橋本祐一
    • Organizer
      日本薬学会132年会
    • Place of Presentation
      北海道札幌市
    • Data Source
      KAKENHI-PROJECT-21790107
  • [Presentation] LiverXReceptor(LXR)リガンドの構造展開によるTransrepression作用選択的リガンドの創製2012

    • Author(s)
      青山惇、梅田(遠藤)香織、谷内出(野口)友美、石川稔、宮地弘幸、槇島誠、橋本祐一
    • Organizer
      日本薬学会132年会
    • Place of Presentation
      北海道札幌市
    • Data Source
      KAKENHI-PROJECT-21790107
  • [Presentation] ジフェニルペンタン骨格を有する選択的抗アンドロゲン物質の創製研究2011

    • Author(s)
      丸山慶輔、谷内出友美、杉田和幸、橋本祐一、石川稔
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      静岡
    • Data Source
      KAKENHI-PROJECT-21790107
  • [Presentation] LXXLL peptide mimetics as inhibitors ofthe interaction of vitamin D receptor2011

    • Author(s)
      Y. Mita, K. Dodo, T. Noguchi- Yachide, H. Miyachi and Y. Hashimoto.
    • Organizer
      AIMECS11, 8th AFMC International Medicinal Chemistry Symposium "Frontier of Medicinal Science"
    • Place of Presentation
      Tokyo
    • Data Source
      KAKENHI-PROJECT-21790107
  • [Presentation] Further application of the multi-template approach for creation of biologically active compounds: discovery of a new class of multifunctional anti-diabetic agents.2011

    • Author(s)
      K. Sugita, K. Motoshima, T. Noguchi- Yachide, M. Ishikawa and Y. Hashimoto.
    • Organizer
      AIMECS11, 8th AFMC International Medicinal Chemistry Symposium "Frontier of Medicinal Science"
    • Place of Presentation
      Tokyo
    • Data Source
      KAKENHI-PROJECT-21790107
  • [Presentation] Improvement in aqueous solubility of biocyclic molecules by disruption of molecular planarity and symmetry2011

    • Author(s)
      M. Ishikawa, Y. Fujita, J. Kasuga, M. Yonehara, T. Noguchi - Ychide, H. Miyachi and Y. Hashimoto
    • Organizer
      AIMECS11, 8th AFMC International Medicinal Chemistry Symposium "Frontier of Medicinal Science"
    • Place of Presentation
      Tokyo
    • Data Source
      KAKENHI-PROJECT-21790107
  • [Presentation] LXR依存的なTransrepression作用選択的リガンドの創製2011

    • Author(s)
      青山惇、遠藤香織、谷内出友美、青山洋史、石川稔、槇島誠、宮地弘幸、橋本祐一
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      静岡
    • Data Source
      KAKENHI-PROJECT-21790107
  • [Presentation] ss-Naphthoflavone analogs as potent and soluble aryl hydrocarbon receptor agonists: Improvement of solubility by disruption of molecular planarity.2010

    • Author(s)
      Y. Fuj i t a, M. Yonehara, M. Tetsuhashi, T. Noguchi - Yachi de, Y. Hashimoto and M. Ishikawa
    • Organizer
      The International Chemical Congress of Pacific Basin Societies
    • Place of Presentation
      Hawaii
    • Data Source
      KAKENHI-PROJECT-21790107
  • [Presentation] Selective anti-androgens with a 3,3-diphenylpentane skeleton2010

    • Author(s)
      K.Maruyama, M.Ishikawa, T.Noguchi-Yachide, Y.Hashimoto
    • Organizer
      International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2010)
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Data Source
      KAKENHI-PROJECT-22249006
  • [Presentation] LXRを介した抗炎症作用を有する選択的リガンドの創製2010

    • Author(s)
      青山惇、谷内出友美、青山洋史、石川稔、槇島誠、宮地弘幸、橋本祐一
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Data Source
      KAKENHI-PROJECT-21790107
  • [Presentation] LXXLL配列を模倣したビタミンD受容体-コアクチベーター相互作用阻害物質の創製-2010

    • Author(s)
      三田裕介、どど孝介、谷内出友美、宮地弘幸、橋本祐一、石川稔
    • Organizer
      第29回メディシナルケミストリーシンポジウム
    • Place of Presentation
      京都テレサ
    • Data Source
      KAKENHI-PROJECT-21790107
  • [Presentation] LXXLL配列を模倣した核内受容体-コアクチベーター阻害物質の創製2010

    • Author(s)
      三田裕介、どど孝介、谷内出友美、宮地弘幸、橋本祐一、石川稔
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Data Source
      KAKENHI-PROJECT-21790107
  • [Presentation] 難溶性を改善したAhRリガンドの創製2010

    • Author(s)
      藤田優史、米原光拡、鉄橋正士、谷内出友美、橋本祐一、石川稔
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Data Source
      KAKENHI-PROJECT-21790107
  • [Presentation] Selective anti-androgens with a 3,3-diphenylpentane skeleton .2010

    • Author(s)
      K. Maruyama, M. Ishikawa, T. Noguchi- Yachi de and Y. Hashimoto
    • Organizer
      The International Chemical Congress of Pacific Basin Societies
    • Place of Presentation
      Hawaii
    • Data Source
      KAKENHI-PROJECT-21790107
  • [Presentation] 難溶性を改善したAhRリガンドの創製2010

    • Author(s)
      藤田優史、米原光拡、鉄橋正士、谷内出友美、橋本祐一、石川稔
    • Organizer
      第29回メディシナルケミストリーシンポジウム
    • Place of Presentation
      京都テレサ
    • Data Source
      KAKENHI-PROJECT-21790107
  • [Presentation] サリドマイド誘導体におけるα-glucosidaseとLXR活性の作用分離、およびglycogenphosphorylase阻害活性2009

    • Author(s)
      島和典、石川稔、谷内出友美、杉田和幸、橋本祐一
    • Organizer
      第28回メディシナルケミストリーシンポジウム
    • Place of Presentation
      東京大学
    • Data Source
      KAKENHI-PROJECT-21790107
  • [Presentation] サリドマイド誘導体におけるα-glucosidase とLXR活性の作用分離2009

    • Author(s)
      本島和典、谷内出友美、他4 名 (4 番目)
    • Organizer
      日本薬学会第129 年会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-18790084
  • [Presentation] 3,3-diindolylmethane (DIM)誘導体におけるHL-60細胞分化促進活性2009

    • Author(s)
      谷内出友美、鉄橋正士、青山洋史、橋本祐一
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都
    • Year and Date
      2009-03-26
    • Data Source
      KAKENHI-PROJECT-19390028
  • [Presentation] 環状イミドを有するヒダントイン類の合成と活性評価2009

    • Author(s)
      山口淳一、谷内出友美、坂口由佳、柴田千秋、橋本祐一
    • Organizer
      第28回メディシナルケミストリーシンポジウム
    • Place of Presentation
      東京大学
    • Data Source
      KAKENHI-PROJECT-21790107
  • [Presentation] 3, 3-diindolylmethane (DIM)誘導体におけるHL-60細胞分化促進活性2009

    • Author(s)
      谷内出友美、鉄橋正士、青山洋史、橋本祐一
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都
    • Year and Date
      2009-03-27
    • Data Source
      KAKENHI-PROJECT-17016013
  • [Presentation] 3,3'-Diindolylmethane (DIM)誘導体におけるHL-60 細胞分化誘導促進活性2009

    • Author(s)
      谷内出友美、他3 名 (1 番目)
    • Organizer
      日本薬学会第129 年会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-18790084
  • [Presentation] 3,3'-Diindolylmethane(DIM)誘導体におけるHL-60細胞分化誘導促進活性2009

    • Author(s)
      谷内出(野口)友美, 他3名
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都国際会館
    • Year and Date
      2009-03-28
    • Data Source
      KAKENHI-PROJECT-18790084
  • [Presentation] サリドマイドヒドロキシル化代謝物のキラル部位フッ素置換体の合成と生物活性2008

    • Author(s)
      斉藤智之、谷内出友美、他4 名 (5 番目)
    • Organizer
      日本薬学会第128 年会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-18790084
  • [Presentation] Galloyl 基誘導体の合成と活性評価2008

    • Author(s)
      湊太郎、谷内出友美、他8 名 (3 番目)
    • Organizer
      日本薬学会第128 年会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-18790084
  • [Presentation] エピマー化しないサリドマイド代謝物等価体の設計,合成,および生物活性2008

    • Author(s)
      藤原朋也、谷内出友美、他4 名 (5 番目)
    • Organizer
      Symposium on molecular chirality 2008
    • Place of Presentation
      岡山大学創立五十周年記念館
    • Data Source
      KAKENHI-PROJECT-18790084
  • [Presentation] Fusarielin A の生物活性をその分子基盤2008

    • Author(s)
      藤本悠、谷内出(野口)友美、他3 名 (3 番目)
    • Organizer
      日本薬学会第128 年会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-18790084
  • [Presentation] Fusarielin A の生物活性とその分子基盤2007

    • Author(s)
      藤本悠、谷内出友美、他3 名(2 番目)
    • Organizer
      第49 回天然有機化合物討論会
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-18790084
  • [Presentation] Bioresponse regulators derived from thalidomide2007

    • Author(s)
      Tomomi Noguchi, 他3名
    • Organizer
      Pharmaceutical sciences world congress 2007
    • Place of Presentation
      アムステルダム(オランダ)
    • Year and Date
      2007-04-24
    • Data Source
      KAKENHI-PROJECT-18790084
  • [Presentation] Bioresponse regulators derived from thalidomide2007

    • Author(s)
      Tomomi Noguchi 、他3 名 (1 番目)
    • Organizer
      Pharmaceutical sciences world congress
    • Place of Presentation
      Amsterdam
    • Data Source
      KAKENHI-PROJECT-18790084
  • [Presentation] アルキルガレート誘導体の合成とその生物活性2007

    • Author(s)
      湊太郎、野口友美、他8 名 (2 番目)
    • Organizer
      日本薬学会第127 年会
    • Place of Presentation
      富山
    • Data Source
      KAKENHI-PROJECT-18790084
  • [Presentation] 新規血管新生阻害剤の作用解析2007

    • Author(s)
      藤本悠、野口友美、他3 名(2 番目)
    • Organizer
      日本薬学会第127 年会
    • Place of Presentation
      富山
    • Data Source
      KAKENHI-PROJECT-18790084
  • [Presentation] サリドマイドのマルチ創薬テンプレートとしての活用2007

    • Author(s)
      野口友美、他1 名 (1 番目)
    • Organizer
      東京大学臨床展開シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2007-03-02
    • Data Source
      KAKENHI-PROJECT-18790084
  • [Presentation] サリドマイド加水分解代謝物のフッ素置換体の合成と生物活性試験2007

    • Author(s)
      斉藤智之、谷内出友美、他4名 (4番目)
    • Organizer
      第26回メディシナルケミストリーシンポジウム
    • Place of Presentation
      相模原
    • Data Source
      KAKENHI-PROJECT-18790084
  • [Presentation] サリドマイド由来α-グルコシダーゼ阻害剤をリードとしたLXR アンタゴニストの創製2007

    • Author(s)
      青山洋史、谷内出友美、他4 名 (3 番目)
    • Organizer
      第26 回メディシナルケミストリーシンポジウム
    • Place of Presentation
      相模原
    • Data Source
      KAKENHI-PROJECT-18790084
  • [Presentation] サリドマイドの活性に及ぼす代謝の影響と構造展開2007

    • Author(s)
      野口友美、他4 名 (1 番目)
    • Organizer
      日本薬学会第127 年会
    • Place of Presentation
      富山
    • Data Source
      KAKENHI-PROJECT-18790084
  • [Presentation] サリドマイドの構造展開による微小管タンパク質重合阻害剤の開発2007

    • Author(s)
      青山洋史、野口友美、他4 名 (3 番目)
    • Organizer
      日本薬学会第127 年会
    • Place of Presentation
      富山
    • Data Source
      KAKENHI-PROJECT-18790084
  • [Presentation] Some bioresponse modifires derived from thalidomide2006

    • Author(s)
      Tomomi Noguchi、他5 名
    • Organizer
      The 7^<th> Tetrahedron Symposium
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-18790084
  • 1.  HASHIMOTO Yuichi (90164798)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 26 results
  • 2.  KOBAYASHI Hisayoshi (80225531)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 2 results
  • 3.  AOYAMA Hiroshi (40374699)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 3 results
  • 4.  ISHIKAWA Minoru (70526839)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 10 results
  • 5.  SUGITA Kazuyuki (60542090)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 6.  MATSUMOTO Yotaro (90420041)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 7.  MISAWA Takashi (40709820)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  FUJII Shinya (60389179)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 9.  KITTAKA Atsushi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 10.  大金 賢司
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results

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